TY  - JOUR
AU  - Zseli, J
AU  - Bősze, Péter
AU  - Lakatos, Péter
AU  - Vargha, P
AU  - Tarjan, G
AU  - Kollin, E
AU  - Horváth, Csaba
AU  - Laszlo, J
AU  - Hollo, I
TI  - Serum bone GLA protein in streak gonad syndrome
JF  - CALCIFIED TISSUE INTERNATIONAL
J2  - CALCIFIED TISSUE INT
VL  - 48
PY  - 1991
IS  - 6
SP  - 387
EP  - 391
PG  - 5
SN  - 0171-967X
DO  - 10.1007/BF02556451
UR  - https://m2.mtmt.hu/api/publication/1802383
ID  - 1802383
N1  - First Department of Medicine, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary            
            Department of Obstetrics and Gynecology, Postgraduate Medical School, Budapest, Hungary            
            Biometrical and Clinico-Epidemiological Unit, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary            
            Cited By :5            
            Export Date: 13 February 2021            
            CODEN: CTIND            
            Correspondence Address: Zséli, J.; First Department of Medicine, Korányi S. 2/a, Budapest, H-1083, Hungary            
            Chemicals/CAS: alkaline phosphatase, 9001-78-9; ethinylestradiol, 57-63-6; norethisterone, 68-22-4; osteocalcin, 136461-80-8; Alkaline Phosphatase, EC 3.1.3.1; Calcium, 7440-70-2; Estrogens; Minerals; Osteocalcin, 104982-03-8; Phosphorus, 7723-14-0; Progestational Hormones
First Department of Medicine, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary            
            Department of Obstetrics and Gynecology, Postgraduate Medical School, Budapest, Hungary            
            Biometrical and Clinico-Epidemiological Unit, Semmelweis University Medical School, Korányi S. 2/a, Budapest, H-1083, Hungary            
            Cited By :5            
            Export Date: 26 May 2021            
            CODEN: CTIND            
            Correspondence Address: Zséli, J.; First Department of Medicine, Korányi S. 2/a, Budapest, H-1083, Hungary            
            Chemicals/CAS: alkaline phosphatase, 9001-78-9; ethinylestradiol, 57-63-6; norethisterone, 68-22-4; osteocalcin, 136461-80-8; Alkaline Phosphatase, EC 3.1.3.1; Calcium, 7440-70-2; Estrogens; Minerals; Osteocalcin, 104982-03-8; Phosphorus, 7723-14-0; Progestational Hormones
AB  - Osteoporosis is one of the most common complications of streak gonad syndrome (SGS), however its pathogenesis is still unclear. Bone Gla protein (BGP) has been found to be a serum marker of bone turnover in various metabolic disease states. In the present study serum BGP and alkaline phosphatase (AP) were measured in 13 osteoporotic patients with SGS and in 56 healthy women. Mean (±SD) serum BGP levels were normal (7.5 ± 2.0 ng/ml) in seven patients who had been on estrogen-progestin replacement therapy and became significantly elevated (P < 0.001) 2 and 3 months after discontinuation of the treatment (15.3 ± 2.3 and 13.2 ± 1.0 ng/ml, respectively). Mean (±SD) serum AP (207 ± 65 U/l) showed significant increases (P < 0.05) 2 months after withdrawal of hormonal substitution (287 ± 74 U/l). Mean (±SD) serum BGP (15.4 ± 3.5) and AP (287 ± 49) levels were significantly higher (P < 0.001 and < 0.05, respectively) in six patients with SGS who had not been on hormonal substitution. These findings are consistent with those obtained in postmenopausal women suffering from ''high remodelling osteoporosis'' and suggest that bone turnover in osteoporotic patients with SGS is increased and the skeletal loss is a consequence of accelerated bone loss rather than decreased bone formation.
LA  - English
DB  - MTMT
ER  -