TY  - JOUR
AU  - Yang, LX
AU  - Ho, NY
AU  - Müller, Ferenc
AU  - Strahle, U
TI  - Methyl Mercury Suppresses the Formation of the Tail Primordium in Developing Zebrafish Embryos
JF  - TOXICOLOGICAL SCIENCES
J2  - TOXICOL SCI
VL  - 115
PY  - 2010
IS  - 2
SP  - 379
EP  - 390
PG  - 12
SN  - 1096-6080
DO  - 10.1093/toxsci/kfq053
UR  - https://m2.mtmt.hu/api/publication/21324564
ID  - 21324564
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Scholz, Stefan
AU  - Fischer, S.
AU  - Gündel, U.
AU  - Küster, E.
AU  - Luckenbach, T.
AU  - Voelker, D.
TI  - The zebrafish embryo model in environmental risk assessment - Applications beyond acute toxicity testing
JF  - ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
J2  - ENVIRON SCI POLLUT R
VL  - 15
PY  - 2008
IS  - 5
SP  - 394
EP  - 404
PG  - 11
SN  - 0944-1344
DO  - 10.1007/s11356-008-0018-z
UR  - https://m2.mtmt.hu/api/publication/30743403
ID  - 30743403
N1  - Department of Cell Toxicology, UFZ-Helmholtz Centre for Environmental Research, Permoserstr. 15, Leipzig 04318, Germany            
Department of Bioanalytical Ecotoxicology, UFZ-Helmholtz Centre for Environmental Research, Permoserstr. 15, Leipzig 04318, Germany            
   
Correspondence Address: Scholz, S.; Department of Cell Toxicology, UFZ-Helmholtz Centre for Environmental Research, Permoserstr. 15, Leipzig 04318, Germany; email: stefan.scholz@ufz.de
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hadzhiev, Y
AU  - Lele, Zsolt
AU  - Schindler, S
AU  - Wilson, SW
AU  - Ahlberg, P
AU  - Strahle, U
AU  - Müller, Ferenc
TI  - Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish
JF  - BMC DEVELOPMENTAL BIOLOGY
J2  - BMC DEV BIOL
VL  - 7
PY  - 2007
PG  - 12
SN  - 1471-213X
DO  - 10.1186/1471-213X-7-75
UR  - https://m2.mtmt.hu/api/publication/109654
ID  - 109654
N1  - Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, D-76021 Karlsruhe, Germany            
            Department of Anatomy and Developmental Biology, University College London, Gower street, London, WC1E 6BT, United Kingdom            
            Department of Evolutionary Organismal Biology, Evolutionary Biology Centre, Uppsala University, SE-752 36, Uppsala, Sweden            
            Department of Gene Technology and Developmental Neurobiology, Institute for Experimental Medicine, Szigony u. 43, H-1083, Budapest, Hungary            
            Cited By :22            
            Export Date: 27 April 2020            
            Correspondence Address: Müller, F.; Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, D-76021 Karlsruhe, Germany; email: ferenc.mueller@itg.fzk.de            
            Chemicals/CAS: cyclopamine, 4449-51-8; cyclopamine, 4449-51-8; Green Fluorescent Proteins, 147336-22-9; Hedgehog Proteins; Veratrum Alkaloids; Zebrafish Proteins
AB  - BACKGROUND: Little is known about the control of the development of vertebrate unpaired appendages such as the caudal fin, one of the key morphological specializations of fishes. Recent analysis of lamprey and dogshark median fins suggests the co-option of some molecular mechanisms between paired and median in Chondrichthyes. However, the extent to which the molecular mechanisms patterning paired and median fins are shared remains unknown. RESULTS: Here we provide molecular description of the initial ontogeny of the median fins in zebrafish and present several independent lines of evidence that Sonic hedgehog signaling emanating from the embryonic midline is essential for establishment and outgrowth of the caudal fin primordium. However, gene expression analysis shows that the primordium of the adult caudal fin does not harbor a Sonic hedgehog-expressing domain equivalent to the Shh secreting zone of polarizing activity (ZPA) of paired appendages. CONCLUSION: Our results suggest that Hedgehog proteins can regulate skeletal appendage outgrowth independent of a ZPA and demonstrates an unexpected mechanism for mediating Shh signals in a median fin primordium. The median fins evolved before paired fins in early craniates, thus the patterning of the median fins may be an ancestral mechanism that controls the outgrowth of skeletogenic appendages in vertebrates.
LA  - English
DB  - MTMT
ER  -