@article{MTMT:21324564, title = {Methyl Mercury Suppresses the Formation of the Tail Primordium in Developing Zebrafish Embryos}, url = {https://m2.mtmt.hu/api/publication/21324564}, author = {Yang, LX and Ho, NY and Müller, Ferenc and Strahle, U}, doi = {10.1093/toxsci/kfq053}, journal-iso = {TOXICOL SCI}, journal = {TOXICOLOGICAL SCIENCES}, volume = {115}, unique-id = {21324564}, issn = {1096-6080}, year = {2010}, eissn = {1096-0929}, pages = {379-390}, orcid-numbers = {Müller, Ferenc/0000-0002-0996-774X} } @article{MTMT:30743403, title = {The zebrafish embryo model in environmental risk assessment - Applications beyond acute toxicity testing}, url = {https://m2.mtmt.hu/api/publication/30743403}, author = {Scholz, Stefan and Fischer, S. and Gündel, U. and Küster, E. and Luckenbach, T. and Voelker, D.}, doi = {10.1007/s11356-008-0018-z}, journal-iso = {ENVIRON SCI POLLUT R}, journal = {ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH}, volume = {15}, unique-id = {30743403}, issn = {0944-1344}, year = {2008}, eissn = {1614-7499}, pages = {394-404} } @article{MTMT:109654, title = {Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish}, url = {https://m2.mtmt.hu/api/publication/109654}, author = {Hadzhiev, Y and Lele, Zsolt and Schindler, S and Wilson, SW and Ahlberg, P and Strahle, U and Müller, Ferenc}, doi = {10.1186/1471-213X-7-75}, journal-iso = {BMC DEV BIOL}, journal = {BMC DEVELOPMENTAL BIOLOGY}, volume = {7}, unique-id = {109654}, issn = {1471-213X}, abstract = {BACKGROUND: Little is known about the control of the development of vertebrate unpaired appendages such as the caudal fin, one of the key morphological specializations of fishes. Recent analysis of lamprey and dogshark median fins suggests the co-option of some molecular mechanisms between paired and median in Chondrichthyes. However, the extent to which the molecular mechanisms patterning paired and median fins are shared remains unknown. RESULTS: Here we provide molecular description of the initial ontogeny of the median fins in zebrafish and present several independent lines of evidence that Sonic hedgehog signaling emanating from the embryonic midline is essential for establishment and outgrowth of the caudal fin primordium. However, gene expression analysis shows that the primordium of the adult caudal fin does not harbor a Sonic hedgehog-expressing domain equivalent to the Shh secreting zone of polarizing activity (ZPA) of paired appendages. CONCLUSION: Our results suggest that Hedgehog proteins can regulate skeletal appendage outgrowth independent of a ZPA and demonstrates an unexpected mechanism for mediating Shh signals in a median fin primordium. The median fins evolved before paired fins in early craniates, thus the patterning of the median fins may be an ancestral mechanism that controls the outgrowth of skeletogenic appendages in vertebrates.}, year = {2007}, orcid-numbers = {Müller, Ferenc/0000-0002-0996-774X} }