@article{MTMT:1419727,
	title = {Does White Wine Qualify for French Paradox? Comparison of the Cardioprotective Effects of Red and White Wines and Their Constituents: Resveratrol, Tyrosol, and Hydroxytyrosol},
	url = {https://m2.mtmt.hu/api/publication/1419727},
	author = {Dudley, JI and Lekli, István and Mukherjee, S and Das, M and Bertelli, AAA and Das, DK},
	doi = {10.1021/jf801791d},
	journal-iso = {J AGR FOOD CHEM},
	journal = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY},
	volume = {56},
	unique-id = {1419727},
	issn = {0021-8561},
	abstract = {It is generally believed that the French paradox is related to the consumption of red wine and not other varieties of wine, including white wine or champagne. Some recent studies have indicated that white wine could also be as cardioprotective as red wine. The present investigation compares the cardioprotective abilities of red wine, white wine, and their principal cardioprotective constituents. Different groups of rats were gavaged with red wine, white wine, resveratrol, tyrosol, and hydroxytyrosol. Red wine and its constituent resveratrol and white wine and its constituents tyrosol and hydroxytyrosol all showed different degrees of cardioprotection as evidenced by their abilities to improve postischemic ventricular performance, reduce myocardial infarct size and cardiomyocyte apoptosis, and reduce peroxide formation. It was discovered in this study that although each of the wines and their components increased the enzymatic activities of the mitochondrial complex (I−IV) and citrate synthase, which play very important roles in oxidative phosphorylation and ATP synthesis, some of the groups were more complex-specific in inducing the activity compared to the other groups. Cardioprotective ability was further confirmed by increased expression of phospho-Akt, Bcl-2, eNOS, iNOS, COX-1, COX-2, Trx-1, Trx-2, and HO-1. The results of this study suggest that white wine can provide cardioprotection similar to red wine if it is rich in tyrosol and hydroxytyrosol.},
	year = {2008},
	eissn = {1520-5118},
	pages = {9362-9373}
}

@article{MTMT:1195203,
	title = {Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts},
	url = {https://m2.mtmt.hu/api/publication/1195203},
	author = {Bak, István and Lekli, István and Juhász, Béla and Nagy, N and Varga, E and Váradi, Judit and Gesztelyi, Rudolf and Szabo, G and Szendrei, L and Bácskay, Ildikó and Vecsernyés, Miklós and Antal, Miklós and Fésüs, László and Boucher, F and de Leiris, J and Tósaki, Árpád},
	doi = {10.1152/ajpheart.01243.2005},
	journal-iso = {AM J PHYSIOL HEART C},
	journal = {AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY},
	volume = {291},
	unique-id = {1195203},
	issn = {0363-6135},
	abstract = {Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts. Am J Physiol Heart Circ Physiol 291: H1329-H1336, 2006. First published April 14, 2006; doi: 10.1152/ajpheart.01243.2005. The effects of kernel extract obtained from sour cherry (Prunus cerasus) seed on the postischemic cardiac recovery were studied in isolated working rat hearts. Rats were treated with various daily doses of the extract for 14 days, and hearts were then isolated and subjected to 30 min of global ischemia followed by 120 min of reperfusion. The incidence of ventricular fibrillation (VF) and tachycardia (VT) fell from their control values of 92% and 100% to 50% (not significant) and 58% (not significant), 17% (P < 0.05), and 25% (P < 0.05) with the doses of 10 mg/kg and 30 mg/kg of the extract, respectively. Lower concentrations of the extract (1 and 5 mg/kg) failed to significantly reduce the incidence of VF and VT during reperfusion. Sour cherry seed kernel extract (10 and 30 mg/kg) significantly improved the postischemic recovery of cardiac function (coronary flow, aortic flow, and left ventricular developed pressure) during reperfusion. We have also demonstrated that the extract-induced protection in cardiac function significantly reflected in a reduction of infarct size. Immunohistochemistry indicates that a reduction in caspase-3 activity and apoptotic cells by the extract, beside other potential action mechanisms of proanthocyanidin, trans-resveratrol, and flavonoid components of the extract, could be responsible for the cardioprotection in ischemic-reperfused myocardium.},
	keywords = {Animals; Male; APOPTOSIS; RATS; Rats, Sprague-Dawley; Incidence; Dose-Response Relationship, Drug; Caspases/metabolism; *Phytotherapy; Plant Extracts/therapeutic use; Caspase 3; Myocardial Infarction/pathology; Myocardium/metabolism/*pathology; Ventricular Fibrillation/drug therapy/pathology/prevention & control; Tachycardia/drug therapy/pathology/prevention & control; *Seeds; Reperfusion Injury/*drug therapy/pathology/*prevention & control; *Prunus},
	year = {2006},
	eissn = {1522-1539},
	pages = {H1329-H1336},
	orcid-numbers = {Gesztelyi, Rudolf/0000-0001-7911-055X}
}