TY - CHAP AU - Kovács, Levente AU - Szalay, Péter AU - Benyó, Balázs István AU - Chase, JG ED - Jobbágy, Ákos TI - Optimal tight glycaemic control supported by differential geometric methods T2 - 5th European Conference of the International Federation for Medical and Biological Engineering PB - Springer Netherlands CY - Berlin CY - Heidelberg SN - 9783642235078 T3 - IFMBE Proceedings, ISSN 1680-0737 ; 37. PY - 2012 SP - 351 EP - 354 PG - 4 DO - 10.1007/978-3-642-23508-5_91 UR - https://m2.mtmt.hu/api/publication/2247379 ID - 2247379 AB - Optimal control of an Intensive Care Unit (ICU) metabolic model from nonlinear control point of view is presented in the current paper. The transformation of a clinically validated nonlinear model into a series of integrators via exact linearization and asymptotic output tracking is performed. Both methods need the value of the state variables; therefore Kalman-filter extended for nonlinear systems is applied. Finally, linear optimal LQ method is applied on the ICU model handled with differential geometric approach. Results are demonstrated on input data recorded in actual clinical environment. © 2011 Springer-Verlag Berlin Heidelberg. LA - English DB - MTMT ER - TY - CONF AU - Kovács, Levente AU - Szalay, Péter AU - Sas, Péter István AU - Németh, Máté AU - Almássy, Zsuzsanna AU - Felszeghy, Enikő AU - Kocsis, Győző AU - Wudi, Krisztina AU - Madarász, Eszter AU - Kerényi, Zsuzsa AU - Fövényi, József AU - Körner, Anna AU - Kautzky, László AU - Grósz, Andrea AU - Soós, Hajnalka AU - Orbán, Andrea AU - Benyó, Balázs István AU - Soós, Andrea AU - Török, András AU - Barkai, László ED - M, Phillip ED - T, Battelino TI - Validation results of a Hungarian artificial pancreas algorithm T2 - 5th International Conference on Advanced Technologies & Treatment for Diabetes C1 - Barcelona PY - 2012 SP - 1 EP - 1 PG - 1 UR - https://m2.mtmt.hu/api/publication/2150955 ID - 2150955 LA - English DB - MTMT ER - TY - CHAP AU - Sápi, Johanna AU - Drexler, Dániel András AU - Harmati, István AU - Sápi, Zoltán AU - Kovács, Levente TI - Linear state-feedback control synthesis of tumor growth control in antiangiogenic therapy T2 - IEEE 10th Jubilee International Symposium on Applied Machine Intelligence and Informatics, SAMI 2012 PB - IEEE Hungary Section CY - Budapest SN - 1457701979 PY - 2012 SP - 143 EP - 148 PG - 6 DO - 10.1109/SAMI.2012.6208945 UR - https://m2.mtmt.hu/api/publication/2679756 ID - 2679756 AB - Cancer diseases are one of the most lethal, incurable diseases today, thus fighting cancer is an actual and urgent problem in clinical practice. Beside classical therapies, a new approach is represented by model-based therapies, where human body works as a complex system. These therapies are called targeted molecular therapies (TMTs). TMTs are fighting specifically against different cancer mechanisms and usually don’t eliminate the whole tumor, but control the tumor into a given state and keep it there. The aim of antiangiogenic cancer therapy is to prevent tumors from forming new blood vessels, because without angiogenesis tumor growth is inhibited. In this paper we analyze a nonlinear tumor growth model and design linear controllers based on a linear model acquired from working point linearization. Realized controllers are state feedback with pole placement, LQ control method and both controllers with state observer. Simulations are carried out and the controllers are analyzed in many aspects, including the working points used at linearization. LA - English DB - MTMT ER - TY - JOUR AU - Drexler, Dániel András AU - Kovács, Levente AU - Sápi, Johanna AU - Harmati, István AU - Benyó, Zoltán TI - Model-based analysis and synthesis of tumor growth under angiogenic inhibition: a case study JF - IFAC PROCEEDINGS VOLUMES J2 - IFAC PROCEEDINGS VOLUMES VL - 44 PY - 2011 IS - 1 Part1 SP - 3753 EP - 3758 PG - 6 SN - 1474-6670 DO - 10.3182/20110828-6-IT-1002.02107 UR - https://m2.mtmt.hu/api/publication/2150940 ID - 2150940 N1 - Bittanti Sergio ; Cenedese Angelo ; Zampieri Sandro (szerk.) Proceedings of the 18th IFAC World Congress, 2011 New York: International Federation of Automatic Control (IFAC), 2011 ISBN: 9783902661937 ISBN: 9781618391223 AB - Anti-angiogenic theraphy is a promising method to fight cancer, however the special therapeutic drugs applied are quite expernsive. The aim of this paper is to define simple therapeutical guidelines for sufficient treatment with the usage of the least amount of drugs possible with the help of control theory. We analyse a nonlinear tumor growth model, and use optimal control to design Linear Quadratic controller for offline simulations. The linear model is gained by working point linearization, after the examination of the possible operation points. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Levente AU - Benyó, Balázs István AU - Bokor, József AU - Benyó, Zoltán TI - Induced L2-norm minimization of glucose-insulin system for Type I diabetic patients JF - COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE J2 - COMPUT METH PROG BIO VL - 102 PY - 2011 IS - 2 SP - 105 EP - 118 PG - 14 SN - 0169-2607 DO - 10.1016/j.cmpb.2010.06.019 UR - https://m2.mtmt.hu/api/publication/1812386 ID - 1812386 N1 - Dept. of Control Engineering and Information Technology, Budapest University of Technology and Economics, Magyar tudósok krt. 2, H-1117 Budapest, Hungary Computer and Automation Research Institute, Hungarian Sciences Academy, Budapest, Hungary Cited By :52 Export Date: 14 July 2021 CODEN: CMPBE Correspondence Address: Kovács, L.; Dept. of Control Engineering and Information Technology, Magyar tudósok krt. 2, H-1117 Budapest, Hungary; email: lkovacs@iit.bme.hu Chemicals/CAS: glucose, 50-99-7, 84778-64-3; insulin, 9004-10-8; Blood Glucose; Insulin, 11061-68-0 Funding details: Hungarian Scientific Research Fund, OTKA, T69055 Funding text 1: This research has been supported by Hungarian National Scientific Research Foundation , Grant No. OTKA T69055 . The authors would like to address special thanks to Dr. Zsuzsanna Almássy from Heim Pál Children Hospital Budapest, Pediatric Department for her advices on diabetological questions; to Prof. J. Geoffrey Chase, Dept. of Mechanical Engineering, Centre for Bio-Engineering, University of Canterbury, Christchurch, New Zealand for the ICU data provided. LA - English DB - MTMT ER - TY - CHAP AU - Kovács, Levente AU - Szalay, Péter AU - Benyó, Balázs István AU - Geoffrey, J. Chase ED - IEEE, null TI - Asymptotic output tracking in blood glucose control. A case study T2 - 50th IEEE Conference on Decision and Control and European Control Conference. (CDC-ECC 2011) PB - IEEE Press CY - New York, New York SN - 9781612848006 T3 - Proceedings of the IEEE Conference on Decision and Control, ISSN 0191-2216 PY - 2011 SP - 59 EP - 64 PG - 6 DO - 10.1109/CDC.2011.6161400 UR - https://m2.mtmt.hu/api/publication/2676873 ID - 2676873 AB - Glucose is the primary source of energy for the human body. Keeping the blood glucose level between certain thresholds is essential for the proper energy transport. Insulin plays a key role in maintaining the glucose homeostasis. Because of its great importance, many models were published on either to describe the glucose-insulin interaction in case of patients under Intensive Care Unit (ICU), or to model Type 1 Diabetes Mellitus (T1DM). Currently for most of the models linear control concepts are used in order to design an appropriate controller. The aim of the current paper is to investigate applicability of nonlinear control theory providing exact mathematical background in the control problem of glucose-insulin interaction. Both ICU and T1DM cases are analyzed on well-known models with different complexity. Our aim is to hide the nonlinearity of the models by transforming the input signal so that the response of the model would mimic the behavior of a linear system; hence extending the validity of linear controllers. The asymptotic tracking problem needs the value of the state variables; therefore extended Kalman-filter is applied. The capabilities of this approach are examined through classical control algorithms and input data recorded in clinical environment. LA - English DB - MTMT ER - TY - CHAP AU - Kovács, Levente AU - Szalay, Péter AU - Ferenci, Tamás AU - Drexler, Dániel András AU - Sápi, Johanna AU - Harmati, István AU - Benyó, Zoltán ED - IEEE, null TI - Modeling and Optimal Control Strategies of Diseases with High Public Health Impact T2 - Intelligent Engineering Systems (INES), 2011 15th IEEE International Conference on PB - IEEE Press CY - New York, New York SN - 9781424489541 PY - 2011 SP - 23 EP - 28 PG - 6 DO - 10.1109/INES.2011.5954713 UR - https://m2.mtmt.hu/api/publication/2150935 ID - 2150935 N1 - Conference code: 86075 Cited By :10 Export Date: 28 June 2021 Correspondence Address: Kovács, L.; Budapest University of Technology and Economics, Budapest, Hungary; email: lkovacs@iit.bme.hu AB - This paper summarizes the results of research tasks in the field of physiological modeling and control of diseases with high public health impact carried out by the Biomedical Engineering Laboratory of the Budapest University of Technology and Economics. The developed and presented optimal algorithms and strategies focus on three diseases with high public health impact diabetes (the question of artificial pancreas), obesity (predicting obesity-related risks) and cancer (antiangiogenic chemotherapy). The studies are done together with different Hungarian hospitals, from where measurement data were obtained. LA - English DB - MTMT ER - TY - THES AU - Kovács, Levente TI - Új elvek és céladekvát algoritmusok az inzulinadagolás szabályozásra cukorbetegek esetében PB - Budapesti Műszaki és Gazdaságtudományi Egyetem PY - 2008 SP - 140 UR - https://m2.mtmt.hu/api/publication/2150869 ID - 2150869 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kovács, Levente AU - Paláncz, Béla TI - Glucose-insulin control of Type1 diabetic patients in H2/H∞ space via Computer Algebra JF - LECTURE NOTES IN COMPUTER SCIENCE J2 - LNCS VL - 4545 PY - 2007 SP - 95 EP - 109 PG - 15 SN - 0302-9743 DO - 10.1007/978-3-540-73433-8_8 UR - https://m2.mtmt.hu/api/publication/2150819 ID - 2150819 N1 - Megjegyzés. Eds.: BE Anai, HHorimoto, KKutsia, 2nd International Conference on Algebraic Biology, AB 2007 Conference code: 70868 Cited By :26 Export Date: 14 July 2021 Correspondence Address: Kovács, L.; Department of Control Engineering and Information Technology, Magyar tudósok krt. 2, H-1117, Budapest, Hungary; email: lkovacs@iit.bme.hu AB - This article presents the H2/Hinf control (disturbance rejection LQ method) of the Bergman minimal model [1] for Type1 diabetic patients under intensive care using computer algebra. To design the optimal controller, the disturbance rejection LQ method based on the minimax differential game is applied. The critical, minimax value of the scaling parameter gamma_crit is determined by using the Modified Riccati Control Algebraic (MCARE) equation employing reduced Groebner basis solution on rational field. The numerical results are in good agreement with those of the Control Toolbox of MATLAB. It turned out, that in order to get positive definite solution stabilizing the closed loop, should be greater than gamma_crit. The obtained results are compared with the classical LQ technique on the original non-linear system, using a standard meal disturbance situation. It is also demonstrated that for gamma >> gamma_crit, the gain matrix approaches the traditional LQ optimal control design solution. The symbolic and numerical computations were carried out with Mathematica 5.2, and with the CSPS Application 2, as well as with MATLAB 6.5. LA - English DB - MTMT ER - TY - JOUR AU - Benyó, Zoltán TI - Education and research in biomedical engineering of the Budapest University of Technology and Economics JF - ACTA PHYSIOLOGICA HUNGARICA J2 - ACTA PHYSIOL HUNG VL - 93 PY - 2006 IS - 1 SP - 13 EP - 21 PG - 9 SN - 0231-424X DO - 10.1556/APhysiol.93.2006.1.2 UR - https://m2.mtmt.hu/api/publication/2623590 ID - 2623590 LA - English DB - MTMT ER - TY - BOOK AU - Lantos, Béla TI - Irányítási rendszerek elmélete és tervezése I. Egyváltozós szabályozások. 2. javított kiadás ET - 0 PB - Akadémiai Kiadó CY - Budapest PY - 2005 SP - 491 SN - 963058249X UR - https://m2.mtmt.hu/api/publication/1044636 ID - 1044636 LA - Hungarian DB - MTMT ER - TY - BOOK AU - Lantos, Béla TI - Irányítási rendszerek elmélete és tervezése ET - 0 PB - Akadémiai Kiadó CY - Budapest PY - 2003 SP - 486 UR - https://m2.mtmt.hu/api/publication/25698 ID - 25698 N1 - hibás ISBN: 9630579227 2. kiadás 2016. ISBN 9789630579919 LA - Hungarian DB - MTMT ER -