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In Western societies, like the United Sates,\ntraumatic brain injury represents an extreme social-economic burden, expected to \nbecome the third leading cause of mortality until 2020. Despite its'\nepidemiological significance, experimental therapeutic modalities developed in\nthe last few decades did not prove efficient in the clinical care of severe\ntraumatic brain injury. The reason for such a lack of success in terms of\ntranslating experimental results to clinical treatment at least partially could\nbe explained by the paucity and the low sensitivity and specificity of clinical\nparameters endowing us to monitor the efficacy of the therapy. The drive for\nfinding clinical parameters and monitoring tools that enable us to monitor\ntreatment efficacy as well as outcome focused recent attention on biomarkers\n(and) surrogate markers that are based on rational pathological processes\nassociated with/operant in traumatic brain injury. 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