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}, { "otype" : "PublicationIdentifier", "mtid" : 172089, "link" : "/api/publicationidentifier/172089", "label" : "Google scholar hash: CWvd1r8yUq8J", "source" : { "otype" : "PlainSource", "mtid" : 13, "link" : "/api/publicationsource/13", "label" : "Google scholar hash", "type" : { "otype" : "PublicationSourceType", "mtid" : 10003, "link" : "/api/publicationsourcetype/10003", "label" : "Indexelő adatbázis", "mayHaveOa" : false, "published" : true, "snippet" : true }, "name" : "Google scholar hash", "nameEng" : "Google scholar hash", "linkPattern" : "http://scholar.Google.com/scholar?hl=en&lr=&cluster=@@@", "publiclyVisible" : true, "published" : true, "oldId" : 13, "snippet" : true }, "oaFree" : false, "validState" : "NO", "idValue" : "CWvd1r8yUq8J", "realUrl" : "http://scholar.Google.com/scholar?hl=en&lr=&cluster=CWvd1r8yUq8J", "published" : false, "oldId" : 1188801, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 2096, "link" : "/api/journal/2096", "label" : "INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 0360-3016 1879-355X", "pIssn" : "0360-3016", "eIssn" : "1879-355X", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 2096, "snippet" : true }, "volume" : "69", "issue" : "3", "firstPage" : "724", "lastPage" : "731", "firstPageOrInternalIdForSort" : "724", "pageLength" : 8, "publishedYear" : 2007, "abstractText" : "PURPOSE: To examine the incidence and clinical relevance of fat necrosis after\naccelerated partial-breast irradiation (PBI) using interstitial high-dose-rate\nbrachytherapy (HDR-BT) in comparison with partial-breast electron irradiation\n(ELE) and whole-breast irradiation (WBI). METHODS AND MATERIALS: Between 1998 and\n2004, 258 early-stage breast cancer patients were randomized to receive 50 Gy WBI\n(n = 130) or PBI (n = 128). The latter consisted of either 7 x 5.2 Gy HDR-BT (n =\n88) or 50 Gy ELE (n = 40). The incidence of fat necrosis, its impact on cosmetic \noutcome, accompanying radiologic features, and clinical symptoms were evaluated. \nRESULTS: The 4-year actuarial rate of fat necrosis was 31.1% for all patients,\nand 31.9%, 36.5%, and 17.7% after WBI, HDR-BT and ELE, respectively\n(p(WBI/HDR-BT) = 0.26; p(WBI/ELE) = 0.11; p(ELE/HDR-BT) = 0.025). The respective \nrate of asymptomatic fat necrosis was 20.2%, 25.3%, and 10% of patients. The\nincidence of symptomatic fat necrosis was not significantly different after WBI\n(8.5%), HDR-BT (11.4%), and ELE (7.5%). Symptomatic fat necrosis was\nsignificantly associated with a worse cosmetic outcome, whereas asymptomatic fat \nnecrosis was not. Fat necrosis was detectable with mammography and/or ultrasound \nin each case. Additional imaging examinations were required in 21% of cases and\naspiration cytology in 42%. CONCLUSIONS: Asymptomatic fat necrosis is a common\nadverse event of breast-conserving therapy, having no significant clinical\nrelevance in the majority of the cases. 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