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All roads lead to disconnection?--traumatic axonal injury revisited
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Traumatic brain injury (TBI) evokes widespread/diffuse axonal injury (TAI)
significantly contributing to its morbidity and mortality. While classic theories
suggest that traumatically injured axons are mechanically torn at the moment of
injury, studies in the last two decades have not supported this premise in the
majority of injured axons. Rather, current thought considers TAI a progressive
process evoked by the tensile forces of injury, gradually evolving from focal
axonal alteration to ultimate disconnection. Recent observations have
demonstrated that traumatically induced focal axolemmal permeability leads to
local influx of Ca2+ with the subsequent activation of the cysteine proteases,
calpain and caspase, that then play a pivotal role in the ensuing pathogenesis of
TAI via proteolytic digestion of brain spectrin, a major constituent of the
subaxolemmal cytoskeletal network, the "membrane skeleton". In this pathological
progression this local Ca2+ overloading with the activation of calpains also
initiates mitochondrial injury that results in the release of cytochrome-c, with
the activation of caspase. Both the activated calpain and caspases then
participate in the degradation of the local axonal cytoskeleton causing local
axonal failure and disconnection. In this review, we summarize contemporary
thought on the pathogenesis of TAI, while discussing the potential diversity of
pathological processes observed within various injured fiber types. The
anterograde and retrograde consequences of TAI are also considered together with
a discussion of various experimental therapeutic approaches capable of
attenuating TAI.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" mtid="10002667"> <a href="/gui2/?type=authors&mode=browse&sel=10002667" target="_blank">Buki, A ✉</a> </span> <span class="author-type"> </span> ; <span class="author-name" > Povlishock, JT </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;1251083" mtid="1251083" target="_blank">All roads lead to disconnection?--traumatic axonal injury revisited</a></div> <div class="pub-info"> <span class="journal-title">ACTA NEUROCHIRURGICA</span> <span class="journal-volume">148</span> : <span class="journal-issue">2</span> <span class="page"> pp. 181-193. , 13 p. </span> <span class="year">(2006)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s00701-005-0674-4" target="_blank" href="https://doi.org/10.1007/s00701-005-0674-4"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000234856900025" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000234856900025"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="31344482308" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-31344482308"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="16362181" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16362181&dopt=Abstract"> PubMed </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:1251083 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core">Forrás Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 440</span> | Független: 426 | Függő: 14 | Nem jelölt: 0 | WoS jelölt: 379 | Scopus jelölt: 425 | WoS/Scopus jelölt: 437 | DOI jelölt: 419 </div> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" mtid="10002667"><a
href="/gui2/?type=authors&mode=browse&sel=10002667" target="_blank">Buki A ✉
(<span class="authorship-author-name">Büki András</span>
<span class="authorAux-mtmt"> Idegsebészet, idegtudományok</span>)
</a>
</span>
<span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Idegsebészeti Klinika</span>
;
<span class="author-name" >Povlishock JT
</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;1251083" target="_blank">All roads lead to disconnection?--traumatic axonal injury revisited</a></div> <div> <span class="journal-title">ACTA NEUROCHIRURGICA</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0001-6268">0001-6268</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/0942-0940">0942-0940</a>)</span>:
<span class="journal-volume">148</span> <span class="journal-issue">2</span>
<span class="page">
pp 181-193
</span> <span class="year">(2006)</span>
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DOI
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<span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 440</span>
| Független: 426
| Függő: 14
| Nem jelölt: 0
| WoS jelölt: 379
| Scopus jelölt: 425
| WoS/Scopus jelölt: 437
| DOI jelölt: 419
</div>
<div class="publication-citation">
<a target="_blank" href="/api/publication?cond=citations.related;eq;1251083&sort=publishedYear,desc&sort=title">
Idézett közlemények száma: 6
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 1251083</span>
| <span class="status-data status-VALIDATED"> Egyeztetett
</span>
<span class="oldId">Régi azonosító: 1251083</span> |
Forrás Idéző
| <span class="type-subtype">Folyóiratcikk
( Szakcikk
)
</span>
| <span class="pub-category">Tudományos</span>
| <span class="publication-sourceOfData">MEDLINE</span>
</div>
<div class="lastModified">Utolsó módosítás: 2023.09.02. 15:45 Milánkovics Róbert (PTE ÁOK admin 4)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: FIC NIH HHS [1-R03-TW0131302A1] Funding Source: Medline; NINDS NIH HHS [NS20193] Funding Source: Medline</pre>
</div></div>