TY - JOUR AU - Jakab, Csaba AU - Rusvai, Miklós AU - Gálfi, Péter AU - Mándoki, Míra AU - Demeter, Zoltán AU - Szabo, Z AU - Kulka, Janina TI - Expression of claudin-5 in hepatoid gland biopsies JF - VETERINARY DERMATOLOGY J2 - VET DERMATOL VL - 21 PY - 2010 IS - 3 SP - 276 EP - 281 PG - 6 SN - 0959-4493 DO - 10.1111/j.1365-3164.2009.00798.x UR - https://m2.mtmt.hu/api/publication/1316214 ID - 1316214 N1 - Megjegyzés-21485583 Chemicals/CAS: Claudins Megjegyzés-21485600 Chemicals/CAS: Claudins Megjegyzés-22428563 Megjegyzés-21743074 Z9: 2 LA - English DB - MTMT ER - TY - JOUR AU - Jakab, Csaba AU - Halász, Judit AU - Kiss, András AU - Schaff, Zsuzsa AU - Rusvai, Miklós AU - Gálfi, Péter AU - Abonyi-Tóth, Zsolt AU - Kulka, Janina TI - Claudin-5 protein is a new differential marker for histopathological differential diagnosis of canine hemangiosarcoma JF - HISTOLOGY AND HISTOPATHOLOGY J2 - HISTOL HISTOPATHOL VL - 24 PY - 2009 IS - 7 SP - 801 EP - 813 PG - 13 SN - 0213-3911 DO - 10.14670/HH-24.801 UR - https://m2.mtmt.hu/api/publication/1237584 ID - 1237584 AB - Aims: Claudin-5 protein is an endothel-specific claudin, present in tight junctions. To evaluate its usefulness as a differential diagnostic marker of canine hemangiosarcomas, the expression of claudin-5 molecule was studied in different canine tumours of vascular origin. Methods and results: Ninety two canine neoplastic tissue samples obtained from necropsies and biopsy specimens were routinely processed and stained immunhistochemically for claudin-5. The neoplastic endothelial cells of canine hemangiosarcomas, hemangiomas, and lymphangiomas showed a strong membrane immunoreactivity for claudin-5, but the other investigated canine malignant and benign tumours, including fibrosarcomas, myxo-, leiomyo-, cardiac rhabdomyo-, neurofibro-, synovial-, osteo-, and chondrosarcomas, spindle cell melanomas, hemangiopericytomas, benign fibroblast proliferations, and leiomyomas were negative for this endothelial marker. In these non-vascular canine tumours intense immunostaining was detected in the endothelial cells of the incorporated intratumoural vessels and neovasculature. The canine splenic hematomas induced by hemangiosarcomas were distinguished from splenic hematomas induced by non-neoplastic lesions by the means of claudin-5 protein. In hemangiosarcomas the percentage of positive neoplastic endothelial cells was higher, and stronger when using the claudin-5 molecule compared to CD31 and vWf. Conclusion: The results show that claudin-5 molecule can be used as a new differential marker, and could also be of a diagnostic value in the differential diagnosis of canine hemangiosarcomas from sarcomas of other origin with hemorrhages or increased vascularization. Claudin-5 could help to reveal neoplastic proliferation of endothelial cells causing splenic hematomas and differentiate these tumours from non-vascular neoplastic splenic lesion. The immunohistochemical detection of the claudin-5 protein had a higher sensitivity than CD31, and vWf antigen in case of canine hemangiosarcomas. LA - English DB - MTMT ER - TY - JOUR AU - Jakab, Csaba AU - Szász, Attila Marcell AU - Kulka, Janina AU - Schaff, Zsuzsa AU - Rusvai, Miklós AU - Németh, Tibor AU - Gálfi, Péter TI - Cutaneous mast cell tumour within a lipoma in a boxer JF - ACTA VETERINARIA HUNGARICA J2 - ACTA VET HUNG VL - 57 PY - 2009 IS - 2 SP - 263 EP - 274 PG - 12 SN - 0236-6290 DO - 10.1556/AVet.57.2009.2.7 UR - https://m2.mtmt.hu/api/publication/1257133 ID - 1257133 LA - English DB - MTMT ER - TY - JOUR AU - Jakab, Csaba AU - Szász, Attila Marcell AU - Kulka, Janina AU - Baska, Ferenc AU - Rusvai, Miklós AU - Gálfi, Péter AU - Németh, Tibor TI - Secondary tumoural valvulopathy in dog JF - ACTA VETERINARIA HUNGARICA J2 - ACTA VET HUNG VL - 57 PY - 2009 SP - 63 EP - 67 PG - 5 SN - 0236-6290 DO - 10.1556/AVet.57.2009.1.6 UR - https://m2.mtmt.hu/api/publication/1435675 ID - 1435675 LA - English DB - MTMT ER - TY - JOUR AU - Szabó, István AU - Kiss, András AU - Schaff, Zsuzsa AU - Sobel, Gábor TI - Claudins as diagnostic and prognostic markers in gynecological cancer JF - HISTOLOGY AND HISTOPATHOLOGY J2 - HISTOL HISTOPATHOL VL - 24 PY - 2009 IS - 12 SP - 1607 EP - 1615 PG - 9 SN - 0213-3911 UR - https://m2.mtmt.hu/api/publication/1237598 ID - 1237598 LA - English DB - MTMT ER - TY - JOUR AU - Jakab, Csaba AU - Halász, Judit AU - Kiss, András AU - Schaff, Zsuzsa AU - Szász, Attila Marcell AU - Rusvai, Miklós AU - Abonyi-Tóth, Zsolt AU - Kulka, Janina TI - Evaluation of microvessel density (MVD) in canine mammary tumours by quantitative immunohistochemistry of the claudin-5 molecule. JF - ACTA VETERINARIA HUNGARICA J2 - ACTA VET HUNG VL - 56 PY - 2008 IS - 4 SP - 495 EP - 510 PG - 16 SN - 0236-6290 DO - 10.1556/AVet.56.2008.4.7 UR - https://m2.mtmt.hu/api/publication/1226976 ID - 1226976 LA - English DB - MTMT ER - TY - JOUR AU - Jakab, Csaba AU - Halász, Judit AU - Szász, Attila Marcell AU - Kiss, András AU - Schaff, Zsuzsa AU - Rusvai, Miklós AU - Gálfi, Péter AU - Kulka, Janina TI - Expression of claudin-1, -2, -3, -4, -5 and -7 proteins in benign and malignant canine mammary gland epithelial tumours JF - JOURNAL OF COMPARATIVE PATHOLOGY J2 - J COMP PATHOL VL - 139 PY - 2008 IS - 4 SP - 238 EP - 245 PG - 8 SN - 0021-9975 DO - 10.1016/j.jcpa.2008.08.001 UR - https://m2.mtmt.hu/api/publication/1175116 ID - 1175116 LA - English DB - MTMT ER -