@article{MTMT:1320902, title = {Incidence of lymphoma in systemic sclerosis: a retrospective analysis of 218 Hungarian patients with systemic sclerosis.}, url = {https://m2.mtmt.hu/api/publication/1320902}, author = {Szekanecz, Éva and Szamosi, Szilvia and Gergely, Lajos and Keszthelyi, P and Szekanecz, Zoltán and Szűcs, Gabriella}, doi = {10.1007/s10067-008-0925-x}, journal-iso = {CLIN RHEUMATOL}, journal = {CLINICAL RHEUMATOLOGY}, volume = {27}, unique-id = {1320902}, issn = {0770-3198}, abstract = {Recent results suggest that B cells may have multiple pathogenic roles in systemic sclerosis (SSc) and there may be increased incidence of B cell lymphomas in SSc. Here, we assessed the prevalence of lymphomas in a large SSc cohort. We analyzed data of 218 Hungarian patients undergoing follow-ups in our institutions between 1995 and 2007. During this follow-up period, there were three SSc patients, who eventually developed B cell lymphoma. The first case is a woman with diffuse cutaneous form of SSc (dcSSc) including pulmonary, cardiac, gastrointestinal, and renal manifestations and anti-topoisomerase I antibody positivity. B cell chronic lymphocytic leukemia (B-CLL) with Zap70 expression (Rai I stage) developed 2 years after the onset of SSc. The second case is a woman with dcSSc presenting with pulmonary, cardiac, and gastroesophageal manifestations. Twenty-one months after disease onset, a chronic small lymphocytic B cell non-Hodgkin's lymphoma was diagnosed from retroperitoneal lymph nodes. Our third case is a woman with dcSSc and no internal organ manifestations. She also developed Zap70-positive B-CLL, stage Rai I 9 months after the onset of SSc. Thus, there were three cases of B cell lymphoma among our 218 SSc patients (1.38%). The association of scleroderma and non-Hodgkin's lymphoma may be a rather uncommon feature; however, the incidence of lymphoma among Hungarian SSc patients may be 1.9-2.5 times higher than that in the general population. In our three patients, B cell lymphoma developed within 2 years after the onset of SSc. Altered B cell function implicated in the pathogenesis of SSc may lead to the development of lymphoid malignancies.}, keywords = {egyetemen (Magyarországon) készült közlemény}, year = {2008}, eissn = {1434-9949}, pages = {1163-1166} } @article{MTMT:1454354, title = {Increased production of the soluble tumor-associated antigens CA19-9, CA125, and CA15-3 in rheumatoid arthritis: potential adhesion molecules in synovial inflammation?}, url = {https://m2.mtmt.hu/api/publication/1454354}, author = {Szekanecz, Éva and Sándor, Zsuzsa and Antal-Szalmás, Péter and Soos, L and Lakos, G and Besenyei, Tímea and Szentpetery, A and Simkovics, E and Szántó, János and Kiss, Emese and Koch, AE and Szekanecz, Zoltán}, doi = {10.1196/annals.1422.037}, journal-iso = {ANN NY ACAD SCI}, journal = {ANNALS OF THE NEW YORK ACADEMY OF SCIENCES}, volume = {1108}, unique-id = {1454354}, issn = {0077-8923}, abstract = {Some tumor-associated antigens (TAAs) are expressed on inflammatory cells. We previously detected carcinoembryonic antigen (CEA; CD66) in the rheumatoid (RA) synovium. The production of CEA, CA19-9, CA125, and CA15.3, may be increased in patients with RA, scleroderma, lupus, and Sjogren's syndrome (SS). Some of these TAAs contain sialylated carbohydrate motifs and they are involved in tumor-associated cell adhesion and metastasis. We assessed levels of TAAs in the sera of RA patients and healthy subjects. Serum TAA levels were correlated with disease markers including serum rheumatoid factor (RF), C-reactive protein (CRP), and anti-CCP antibody levels, DAS28, age disease duration. TAAs including CEA, CA15-3, CA72-4, CA125, and CA19-9, and neuron-specific enolase (NSE) were assessed by immunoassay in the sera of 75 patients with RA and 50 age- and sex-matched healthy controls. Normal upper limits for these TAAs were 3.4 microg/L, 25 kU/L, 6.9 kU/L, 35 kU/L, 34 kU/L, and 16.3 microg/L, respectively. There were significantly more RA patients showing abnormally high levels of CA125 (10.8% versus 7.1%), CA19-9 (8.1% versus 0%), and CA15-3 (17.6% versus 14.3%) in comparison to controls (P < 0.05). The mean absolute serum levels of CA125 (23.9 +/- 1.8 versus 16.8 +/- 2.2 kU/L) and CA19-9 (14.2 +/- 1.2 versus 10.5 +/- 1.6 kU/L) were also significantly higher in RA compared to controls (P < 0.05). Among RA patients, serum CEA showed significant correlation with RF (r = 0.270; P < 0.05). None of the assessed TAAs showed any correlation with CRP, anti-CCP, DAS28, age or disease duration. The concentration of some TAAs may be elevated in the sera of patients with established RA in comparison to healthy subjects. CEA, CA19-9, CA125, and CA15-3 contain carbohydrate motifs and thus they may be involved in synovitis-associated adhesive events. Furthermore, some TAAs, such as CEA, may also correlate with prognostic factors, such as serum RF levels.}, keywords = {Aged; Adult; Female; Middle Aged; Male; Humans; Enzyme-Linked Immunosorbent Assay; C-Reactive Protein/analysis; Autoantibodies/blood; CA-19-9 Antigen/*blood; rheumatoid arthritis; Rheumatoid Factor/blood; Mucin-1/*blood; rheumatoid factor; anti-CCP antibody; CARCINOEMBRYONIC ANTIGEN; Tumor antigens; Synovitis/blood/metabolism; Cell Adhesion Molecules/blood/metabolism; CA-125 Antigen/*blood; Arthritis, Rheumatoid/*blood/immunology/*metabolism}, year = {2007}, eissn = {1749-6632}, pages = {359-371}, orcid-numbers = {Besenyei, Tímea/0000-0001-6514-9779; Kiss, Emese/0000-0002-5399-2379} } @article{MTMT:1454279, title = {Malignancies and soluble tumor antigens in rheumatic diseases.}, url = {https://m2.mtmt.hu/api/publication/1454279}, author = {Szekanecz, Éva and András, Csilla and Sandor, Z and Antal-Szalmás, Péter and Szanto, J and Tamasi, L and Kiss, Emese and Szekanecz, Zoltán}, doi = {10.1016/j.autrev.2006.03.007}, journal-iso = {AUTOIMMUN REV}, journal = {AUTOIMMUNITY REVIEWS}, volume = {6}, unique-id = {1454279}, issn = {1568-9972}, abstract = {Paraneoplastic symptoms, caused by a malignancy, but not directly related to invasion by the tumor or its metastases are the result of a wide variety of tumor-derived biologic mediators like hormones, peptides, antibodies, cytotoxic lymphocytes, autocrine and paracrine mediators. Recognition of paraneoplastic syndromes is important, as it may lead to an early diagnosis of cancer. There is some evidence that systemic inflammatory diseases, such as rheumatoid arthritis (RA), lupus, scleroderma or dermatomyositis may increase the risk for the development of malignancies, predominantly lymphoproliferative disorders. However, reports are somewhat controversial. Immunosuppressive and cytotoxic drugs used in antirheumatic therapy, such as methotrexate, cyclophosphamide, azathioprine or anti-TNF biologicals may also lead to the development of such tumors. Tumor-associated antigens may be produced by inflammatory cells and their production may be increased in RA and other autoimmune diseases.}, keywords = {Humans; Rheumatic Diseases/*immunology/physiopathology; Paraneoplastic Syndromes/*immunology/physiopathology; Autoimmune Diseases/complications/etiology/immunology; Antigens, Neoplasm/*immunology}, year = {2006}, eissn = {1873-0183}, pages = {42-47}, orcid-numbers = {Kiss, Emese/0000-0002-5399-2379} } @article{MTMT:1320942, title = {Increased synovial expression of the adhesion molecules CD66a, CD66b, and CD31 in rheumatoid and osteoarthritis.}, url = {https://m2.mtmt.hu/api/publication/1320942}, author = {Szekanecz, Zoltán and Haines, GK and Harlow, LA and Shah, MR and Fong, TW and Fu, R and Lin, SJ and Koch, AE}, doi = {10.1006/clin.1995.1113}, journal-iso = {CLIN IMMUNOL IMMUNOPATHOL (1972-1999)}, journal = {CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY}, volume = {76}, unique-id = {1320942}, issn = {0090-1229}, abstract = {Leukocyte-endothelial interaction mediated by adhesion molecules may play a role in the ingress of inflammatory cells into the rheumatoid (RA) synovial tissue (ST). A number of these molecules have been shown to be up-regulated in the inflamed compared to normal ST. We studied the distribution of two members of the CD66 carcinoembryonic antigen adhesion molecule family, as well as that of CD31, an antigen structurally related to CD66, on various cell types in the RA compared to osteoarthritic (OA) and normal ST. Immunoperoxidase histochemistry was carried out using monoclonal antibodies to CD66a, CD66b, and CD31. This study was performed on ST from 10 patients with RA, 10 with OA, and 4 normal individuals. CD66a, and CD66b were expressed on RA and OA ST myeloid cells but not on normal ST lining cells and interstitial macrophages, suggesting that these antigens may be specific markers of diseased compared to normal ST macrophages (P < 0.05). CD31 was present on more RA and OA than on normal ST macrophages. Also, CD31 was present on most RA, OA, and normal ST endothelial cells. Our results indicate that the expression of CD66a, CD66b, and CD31, members of the immunoglobulin superfamily of adhesion receptors, is up-regulated on cells of myeloid origin in the inflamed compared to normal ST. These results suggest that the CD66 antigens and CD31 may be involved in the adhesive events in the inflamed synovium.}, year = {1995}, eissn = {1090-2341}, pages = {180-186} }