TY - JOUR AU - Sárközi, L AU - Horváth, E AU - Kónya, Zoltán AU - Kiricsi, Imre AU - Szalay, Brigitta AU - Vezér, Tünde AU - Papp, András TI - Subacute intratracheal exposure of rats to manganese nanoparticles. Behavioral, electrophysiological, and general toxicological effects TS - Behavioral, electrophysiological, and general toxicological effects JF - INHALATION TOXICOLOGY J2 - INHAL TOXICOL VL - 21 PY - 2009 IS - SUPPL. 1 SP - 83 EP - 91 PG - 9 SN - 0895-8378 DO - 10.1080/08958370902939406 UR - https://m2.mtmt.hu/api/publication/1283183 ID - 1283183 AB - The toxicity of manganese-containing airborne particles is an important occupational and environmental problem. In this work, adult male Wistar rats were treated with a nanosuspension of MnO2 of approximately 23nm nominal particle diameter, instilled into the trachea for 3, 6, and 9wk in doses of 2.63 and 5.26mg Mn/kg. The animals' body weight was checked weekly. At the end of treatment, the rats' spontaneous motility was tested in an open field box. Then, spontaneous and stimulus-evoked cortical activity and action potential of the tail nerve were recorded in urethane anesthesia. The rats were finally dissected, organs weights were measured, and the presence of excess Mn in lung and brain samples was determined using scanning electron microscopy with energy-dispersive x-ray spectroscopy. While control rats had normal weight gain, the body weights of the treated rats ceased to grow fürom wk 6 on. The relative weight of the lungs increased in the treated rats, and that of the liver decreased, in a dose- and time-dependent manner; Mn was detected in their lung and brain samples. In the open field activity, the percentage of ambulation and rearing decreased while local activity and immobility increased. The latency of the evoked potentials was lengthened, and the conduction velocity of the tail nerve decreased. These results indicate that the Mn content of instilled nanoparticles had access fürom the airways to the brain, and the resulting damage could be investigated in animals using neuro-functional and general toxicological endpoints. © 2009 Informa UK Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Papp, András AU - Nagymajtényi, László AU - Dési, Illés TI - A study on electrophysiological effects of subchronic cadmium treatment in rats JF - ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY J2 - ENVIRON TOXICOL PHAR VL - 13 PY - 2003 IS - 3 SP - 181 EP - 186 PG - 6 SN - 1382-6689 DO - 10.1016/S1382-6689(02)00160-6 UR - https://m2.mtmt.hu/api/publication/1240498 ID - 1240498 AB - Male Wistar rats were treated for 4, 8 and 12 weeks with 3.5, 7.0 or 14.0 mg/kg cadmium (in the form of cadmium chloride) by gavage. Changes induced in certain electrophysiological parameters - electrocorticogram frequency; latency and duration of cortical sensory evoked potentials; conduction velocity and relative and absolute refractory periods of a peripheral nerve - were analyzed. On the electrocorticogram, increased frequency was seen. Lengthened latency and duration of the cortical evoked potentials, as well as lowered conduction velocity and increased refractory periods in the peripheral nerve, were observed. These changes seemed to increase with the dose and the treatment time and were statistically significant mainly in the highest dose groups following 12 weeks of treatment. The results show that subchronic, low-level exposure by cadmium affects the rat's spontaneous and evoked bioelectric activity and point at the possible consequences in exposed humans. Š 2003 Elsevier Science B.V. All rights reserved. LA - English DB - MTMT ER -