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Such injured axons show progressive \nchange leading to axonal disconnection. Although several theories implicate\ncalcium in the pathogenesis of AI, experimental studies have failed to confirm\nits pivotal role. To explore the contribution of Ca2+-induced proteolysis to\naxonal injury, this study was undertaken in an animal model of TBI employing\nantibodies targeting both calpain-mediated spectrin proteolysis (CMSP) and focal \nneurofilament compaction (NFC), a marker of intra-axonal cytoskeletal\nperturbation, at 15-120 minutes (min) postinjury. Light microscopy (LM) revealed \nthat TBI consistently evoked focal, intra-axonal CMSP that was spatially and\ntemporally correlated with NFC. These changes were seen at 15 min postinjury with\nsignificantly increasing number of axons demonstrating CMSP immunoreactivity over\ntime postinjury. Electron microscopy (EM) demonstrated that at 15 min postinjury \nCMSP was confined primarily to the subaxolemmal network. With increasing survival\n(30-120 min) CMSP filled the axoplasm proper. These findings provide the first\ndirect evidence for focal CMSP in the pathogenesis of generalized/diffuse AI.\nImportantly, they also reveal an initial subaxolemmal involvement prior to\ninduction of a more widespread axoplasmic change indicating a spatial-temporal\ncompartmentalization of the calcium-induced proteolytic process that may be\namenable to rapid therapeutic intervention.", "subjects" : [ { "otype" : "Classification", "mtid" : 12125, "link" : "/api/classification/12125", "label" : "Basic medicine", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12548, "link" : "/api/classification/12548", "label" : "Other medical sciences", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12215, "link" : "/api/classification/12215", "label" : "Clinical medicine", "published" : true, "snippet" : true } ], "digital" : null, "printed" : null, "sourceYear" : 2009, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "NONE", "oaCheckDate" : "2024-03-08", "oaFree" : false, "oaByAuthor" : { "otype" : "Admin", "mtid" : 10022754, "link" : "/api/admin/10022754", "label" : "Róbert Milánkovics (PTE ÁOK admin 5)", "familyName" : "Milánkovics", "givenName" : "Róbert", "published" : true, "oldId" : 10022754, "snippet" : true }, "citationCount" : 229, "citationCountUnpublished" : 0, "citationCountWoOther" : 223, "independentCitCountWoOther" : 187, "nationalOriginCitationCount" : 21, "foreignEditionCitationCount" : 214, "doiCitationCount" : 215, "wosCitationCount" : 207, "scopusCitationCount" : 218, "wosScopusCitationCount" : 223, "wosScopusCitationCountWoOther" : 223, "wosScopusIndependentCitationCount" : 187, "wosScopusIndependentCitationCountWoOther" : 187, "independentCitationCount" : 193, "selfCitationCount" : 36, "unhandledCitationCount" : 0, "citingPubCount" : 229, "independentCitingPubCount" : 193, "citingPubCountWoOther" : 223, "independentCitingPubCountWoOther" : 187, "unhandledCitingPubCount" : 0, "citedPubCount" : 0, "citedCount" : 0, "ratings" : [ { "otype" : "SjrRating", "mtid" : 6176512, "link" : "/api/sjrrating/6176512", "label" : "sjr:D1 (1999) Scopus - Medicine (miscellaneous) JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 0022-3069", "listPos" : 44, "rankValue" : 0.1, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 2701, "link" : "/api/classificationexternal/2701", "label" : "Scopus - Medicine (miscellaneous)", "published" : true, "oldId" : 2701, "snippet" : true }, "ranking" : "D1", "calculation" : "DIRECT", "published" : true, "oldId" : 6176512, "snippet" : true } ], "ratingsForSort" : "D1", "hasCitationDuplums" : false, "userChangeableUntil" : "2016-07-15T10:46:41.000+0000", "publishDate" : "2012-11-15T20:25:30.000+0000", "directInstitutesForSort" : "Idegsebészeti Klinika (PTE / ÁOK)", "ownerAuthorCount" : 1, "ownerInstituteCount" : 10, "directInstituteCount" : 1, "authorCount" : 4, "contributorCount" : 0, "hasQualityFactor" : true, "link" : "/api/publication/1250912", "label" : "Buki A et al. 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