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Several characteristics of rabbit made it\nthe first and classical model for the study of lipoproteins and\natherosclerosis. Rabbit models include normal cholesterol-fed rabbits,\nspontaneous mutants for lipid metabolism and transgenic rabbits. Though\nmost molecular investigations of the cardiovascular system have used\ntransgenic mice, the small rodents do not accurately reflect crucial\nfacets of human cardiovascular physiology, therefore a number of\ndifferent transgenic rabbit models of hypertrophic cardiomyopathy were\ncreated. Transgenic rabbits have been found to be suitable bioreactors\nfor the production of pharmaceutical proteins filling an important\nniche between the laboratory mouse and larger farm mammals. It is the\nsmallest animal that can be used to produce recombinant proteins in its\nmilk or serum both on an experimental and a commercial scale. 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