https://m2.mtmt.hu/ hun 2026-06-06 06:04 true true 1 1 1 1 100 1 1 DESC publishedYear false ASC firstAuthor true ASC title true JournalArticle 1036569 VALIDATED true 0 2017-12-04T09:32:47.000+0000 false 1036569 2026-05-13T01:22:57.105+0000 2025-07-01T22:13:29.216+0000 2006-09-14T22:00:00.000+0000 true 10000449 Karádi István /api/author/10000449 Author true 10000449 2025-07-01T22:13:29.409+0000 2025-07-01T22:13:29.409+0000 2017-12-04T09:32:47.000+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 2017-12-04T09:32:47.000+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10080105 /api/admin/10080105 Kériné Tornyi Katalin true true 2024-10-17T16:18:31.199+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hosszufalusi, N Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression true true /api/journal/1305 REVIEWED true false 1305 false 1305 true 0149-5992 1935-5548 Journal FOREIGN 26 2 452 457 452 6 2003 OBJECTIVE - To compare the clinical parameters, C-peptide levels, pattern of islet cell-specific autoantibodies, and prevalence of predisposing genotypes in subjects with latent autoimmune diabetes in adults (LADA) and those with adult-onset type 1 diabetes with rapid progression. RESEARCH DESIGN AND METHODS - We evaluated the clinical parameters, C-peptide levels, and islet cell-specific autoantibodies in 54 LADA, 57 adult-onset type 1 diabetic, and 190 type 2 diabetic patients. Islet cell autoantibodies were also compared between subgroups of newly diagnosed patients with LADA and those with newly diagnosed adult-onset and childhood-onset type 1 diabetes. The genetic study was performed in subjects with LADA and those with adult-onset type 1 diabetes in comparison with a control population. RESULTS - There were no differences in the clinical parameters between LADA and adult-onset type 1 diabetes. Patients with LADA had lower BMI (P < 0.0001), waist-to-hip ratio (0.0029), total cholesterol (P = 0.001), and triglycerides (P = 0.001); higher HDL cholesterol levels (P < 0.0001); and lower prevalence of hypertension (P = 0.0028) compared with patients with type 2 diabetes. C-peptide levels were similar at onset (P = 0.403) but decreased less rapidly in LADA than in adult-onset type 1 diabetes (P = 0.0253). Single-autoantibody positivity was more often seen in LADA than in type 1 diabetes (P = 0.0001). The prevalence of predisposing HLA-DQB1*0302, -DR4, -DR3, and -DR3/DR4 genotypes and the DR4-DQB1*0302 haplotype were increased in both LADA and adult-onset type 1 diabetic subjects compared with the control population. There were no differences in the frequencies of these risk alleles and haplotypes between the two patient groups. CONCLUSIONS - Subjects with LADA had clinical characteristics similar to those with adult-onset type 1 diabetes with rapid progression. C-peptide levels did not differ at onset but decreased less rapidly in LADA. Patients with LADA rather had single islet cell-specific autoantibody positivity. The prevalence of HLA-DQB1*0302, -DR4, -DR3, and -DR3/DR4 risk alleles and the DR4-DQB1*0302 high-risk haplotype did not differ in the two forms of autoimmune diabetes. 2006 true true true false true false NONE 2026-05-13 false true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 147 0 147 140 8 143 120 118 134 145 145 138 138 140 7 0 147 140 147 140 0 0 0 D1 false 10020065,10007314,10003710 false false false 2017-12-04T09:32:47.000+0000 2013-01-06T17:50:17.000+0000 Akadémikus bibliográfia; I. Sz. Belgyógyászati Klinika (SE / AOK / K); I. Sz. Gyermekgyógyászati Klinika (SE / AOK / K); III. Sz. Belgyógyászati Klinika (SE / AOK / K) 10 31 4 13 0 true 10080105 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 369168 /api/authorship/369168 1 0.07692308 true false Author 10020065 /api/author/10020065 Hosszúfalusi Nóra true 10020065 true Hosszufalusi N true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105963 true PersonAuthorship 369169 /api/authorship/369169 2 0.07692308 false false Author 10012495 /api/author/10012495 Vatay Ágnes Terézia true 10012495 true Vatay A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105964 true PersonAuthorship 369170 /api/authorship/369170 3 0.07692308 false false Rajczy K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105965 true PersonAuthorship 369171 /api/authorship/369171 4 0.07692308 false false Author 10000530 /api/author/10000530 Prohászka Zoltán true 10000530 true Prohaszka Z true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105966 true PersonAuthorship 369172 /api/authorship/369172 5 0.07692308 false false Pozsonyi E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105967 true PersonAuthorship 369173 /api/authorship/369173 6 0.07692308 false false Author 10023828 /api/author/10023828 Horváth Laura true 10023828 true Horvath L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105968 true PersonAuthorship 369174 /api/authorship/369174 7 0.07692308 false false Grosz A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105969 true PersonAuthorship 369175 /api/authorship/369175 8 0.07692308 false false Author 10007314 /api/author/10007314 Gerő László true 10007314 true Gero L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105970 true PersonAuthorship 369176 /api/authorship/369176 9 0.07692308 false false Author 10004559 /api/author/10004559 Madácsy László true 10004559 true Madacsy L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105971 true PersonAuthorship 369177 /api/authorship/369177 10 0.07692308 false false Author 10001049 /api/author/10001049 Romics László true 10001049 true Romics L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105972 true PersonAuthorship 369178 /api/authorship/369178 11 0.07692308 false false Author 10000449 /api/author/10000449 Karádi István true 10000449 true Karadi I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105973 true PersonAuthorship 369179 /api/authorship/369179 12 0.07692308 false false Author 10007973 /api/author/10007973 Füst György true 10007973 true Fust G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 10105974 true PersonAuthorship 369180 /api/authorship/369180 13 0.07692308 false true Author 10003710 /api/author/10003710 Pánczél Pál true 10003710 true Panczel P 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RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2902 /api/classificationexternal/2902 true 2902 true D1 DIRECT true 6049781 true /api/publication/1036569 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10020065"><a href="/gui2/?type=authors&mode=browse&sel=10020065" target="_blank">Hosszufalusi N (<span class="authorship-author-name">Hosszúfalusi Nóra</span> <span class="authorAux-mtmt"> Belgyógyászat, Diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012495"><a href="/gui2/?type=authors&mode=browse&sel=10012495" target="_blank">Vatay A (<span class="authorship-author-name">Vatay Ágnes Terézia</span> <span class="authorAux-mtmt"> Autoimmun betegségek genetikai háttere</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rajczy K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000530"><a href="/gui2/?type=authors&mode=browse&sel=10000530" target="_blank">Prohaszka Z (<span class="authorship-author-name">Prohászka Zoltán</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pozsonyi E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023828"><a href="/gui2/?type=authors&mode=browse&sel=10023828" target="_blank">Horvath L (<span class="authorship-author-name">Horváth Laura</span> <span class="authorAux-mtmt"> Haematológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Grosz A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007314"><a href="/gui2/?type=authors&mode=browse&sel=10007314" target="_blank">Gero L (<span class="authorship-author-name">Gerő László</span> <span class="authorAux-mtmt"> Endokrinológia, anyagcsere, diabetológia, lipid...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10004559"><a href="/gui2/?type=authors&mode=browse&sel=10004559" target="_blank">Madacsy L (<span class="authorship-author-name">Madácsy László</span> <span class="authorAux-mtmt"> Élettudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/I. Sz. Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001049"><a href="/gui2/?type=authors&mode=browse&sel=10001049" target="_blank">Romics L (<span class="authorship-author-name">Romics László</span> <span class="authorAux-mtmt"> Belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000449"><a href="/gui2/?type=authors&mode=browse&sel=10000449" target="_blank">Karadi I (<span class="authorship-author-name">Karádi István</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007973"><a href="/gui2/?type=authors&mode=browse&sel=10007973" target="_blank">Fust G (<span class="authorship-author-name">Füst György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003710"><a href="/gui2/?type=authors&mode=browse&sel=10003710" target="_blank">Panczel P (<span class="authorship-author-name">Pánczél Pál</span> <span class="authorAux-mtmt"> Belgyógyászat, diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/III. Sz. Belgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;1036569" target="_blank">Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression</a></div> <div> <span class="journal-title">DIABETES CARE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0149-5992">0149-5992</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1935-5548">1935-5548</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">2</span> <span class="page"> pp 452-457 </span> <span class="year">(2003)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.2337/diacare.26.2.452" target="_blank" href="https://doi.org/10.2337/diacare.26.2.452"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="000185505000034" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/000185505000034"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="0041591490" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-0041591490"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="12547879" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12547879&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Advanced and Specialized Nursing&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Endocrinology, Diabetes and Metabolism&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Internal Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 147</span> | Független: 140 | Függő: 7 | Nem jelölt: 0 | WoS jelölt: 118 | Scopus jelölt:&nbsp;134 | WoS/Scopus jelölt:&nbsp;145 | DOI jelölt:&nbsp;120 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 1036569</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 1036569</span> | Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="special-affiliations"> Speciális affiliáció: Akadémikus bibliográfia </div> <div class="lastModified">Utolsó módosítás: 2025.07.02. 00:13 Ladányi Gusztáv (MTMT API user, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:18 Ladányi Gusztáv (MTMT API user, admin) Kériné Tornyi Katalin (MTMT ellenőrzés admin5) </div> </div></div>