@article{MTMT:1036569,
	title = {Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression},
	url = {https://m2.mtmt.hu/api/publication/1036569},
	author = {Hosszúfalusi, Nóra and Vatay, Ágnes Terézia and Rajczy, K and Prohászka, Zoltán and Pozsonyi, E and Horváth, Laura and Grosz, A and Gerő, László and Madácsy, László and Romics, László and Karádi, István and Füst, György and Pánczél, Pál},
	doi = {10.2337/diacare.26.2.452},
	journal-iso = {DIABETES CARE},
	journal = {DIABETES CARE},
	volume = {26},
	unique-id = {1036569},
	issn = {0149-5992},
	abstract = {OBJECTIVE - To compare the clinical parameters, C-peptide levels, pattern of islet cell-specific autoantibodies, and prevalence of predisposing genotypes in subjects with latent autoimmune diabetes in adults (LADA) and those with adult-onset type 1 diabetes with rapid progression. RESEARCH DESIGN AND METHODS - We evaluated the clinical parameters, C-peptide levels, and islet cell-specific autoantibodies in 54 LADA, 57 adult-onset type 1 diabetic, and 190 type 2 diabetic patients. Islet cell autoantibodies were also compared between subgroups of newly diagnosed patients with LADA and those with newly diagnosed adult-onset and childhood-onset type 1 diabetes. The genetic study was performed in subjects with LADA and those with adult-onset type 1 diabetes in comparison with a control population. RESULTS - There were no differences in the clinical parameters between LADA and adult-onset type 1 diabetes. Patients with LADA had lower BMI (P < 0.0001), waist-to-hip ratio (0.0029), total cholesterol (P = 0.001), and triglycerides (P = 0.001); higher HDL cholesterol levels (P < 0.0001); and lower prevalence of hypertension (P = 0.0028) compared with patients with type 2 diabetes. C-peptide levels were similar at onset (P = 0.403) but decreased less rapidly in LADA than in adult-onset type 1 diabetes (P = 0.0253). Single-autoantibody positivity was more often seen in LADA than in type 1 diabetes (P = 0.0001). The prevalence of predisposing HLA-DQB1*0302, -DR4, -DR3, and -DR3/DR4 genotypes and the DR4-DQB1*0302 haplotype were increased in both LADA and adult-onset type 1 diabetic subjects compared with the control population. There were no differences in the frequencies of these risk alleles and haplotypes between the two patient groups. CONCLUSIONS - Subjects with LADA had clinical characteristics similar to those with adult-onset type 1 diabetes with rapid progression. C-peptide levels did not differ at onset but decreased less rapidly in LADA. Patients with LADA rather had single islet cell-specific autoantibody positivity. The prevalence of HLA-DQB1*0302, -DR4, -DR3, and -DR3/DR4 risk alleles and the DR4-DQB1*0302 high-risk haplotype did not differ in the two forms of autoimmune diabetes.},
	year = {2003},
	eissn = {1935-5548},
	pages = {452-457},
	orcid-numbers = {Hosszúfalusi, Nóra/0000-0002-9469-372X; Prohászka, Zoltán/0000-0003-1761-7982; Horváth, Laura/0000-0001-8457-3647; Gerő, László/0000-0002-7584-9338; Madácsy, László/0000-0002-7589-6193; Karádi, István/0000-0002-8253-2654; Pánczél, Pál/0000-0001-5337-9489}
}