TY  - JOUR
AU  - Karsai, D
AU  - Zsuga, Judit
AU  - Juhász, Béla
AU  - Der, P
AU  - Szentmiklósi, József András
AU  - Tósaki, Árpád
AU  - Gesztelyi, Rudolf
TI  - Effect of nucleoside transport blockade on the interstitial adenosine level characterized by a novel method in guinea pig atria
JF  - JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
J2  - J CARDIOVASC PHARM
VL  - 47
PY  - 2006
IS  - 1
SP  - 103
EP  - 109
PG  - 7
SN  - 0160-2446
DO  - 10.1097/01.fjc.0000196239.51018.a0
UR  - https://m2.mtmt.hu/api/publication/1191392
ID  - 1191392
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gesztelyi, Rudolf
AU  - Zsuga, Judit
AU  - Juhász, Béla
AU  - Der, P
AU  - Vecsernyés, Miklós
AU  - Szentmiklósi, József András
TI  - Concentration estimation via curve fitting. Quantification of negative inotropic agents by using a simple mathematical method in guinea pig atria
TS  - Quantification of negative inotropic agents by using a simple mathematical method in guinea pig atria
JF  - BULLETIN OF MATHEMATICAL BIOLOGY
J2  - B MATH BIOL
VL  - 66
PY  - 2004
IS  - 5
SP  - 1439
EP  - 1453
PG  - 15
SN  - 0092-8240
DO  - 10.1016/j.bulm.2004.03.001
UR  - https://m2.mtmt.hu/api/publication/1167719
ID  - 1167719
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gesztelyi, Rudolf
AU  - Zsuga, Judit
AU  - Hajdu, Péter Béla
AU  - Szabó, Judit Zsuzsanna
AU  - Cseppento, A
AU  - Szentmiklósi, József András
TI  - Positive inotropic effect of the inhibition of cyclic GMP-Stimulated 3 ',5 '-cyclic nucleotide phosphodiesterase (PDE2) on guinea pig left atria in eu- and hyperthyroidism
JF  - GENERAL PHYSIOLOGY AND BIOPHYSICS
J2  - GEN PHYSIOL BIOPHYS
VL  - 22
PY  - 2003
IS  - 4
SP  - 501
EP  - 513
PG  - 13
SN  - 0231-5882
UR  - https://m2.mtmt.hu/api/publication/1191387
ID  - 1191387
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tósaki, Árpád
AU  - Braquet, P
TI  - DMPO and reperfusion injury: arrhythmia, heart function, electron spin resonance, and nuclear magnetic resonance studies in isolated working guinea pig hearts
JF  - AMERICAN HEART JOURNAL
J2  - AM HEART J
VL  - 120
PY  - 1990
IS  - 4
SP  - 819
EP  - 830
PG  - 12
SN  - 0002-8703
DO  - 10.1016/0002-8703(90)90197-6
UR  - https://m2.mtmt.hu/api/publication/1163608
ID  - 1163608
AB  - With the use of isolated working guinea pig hearts with normothermic global ischemia, it was shown that 5,5-dimethyl-pirroline-N-oxide (DMPO), an organic spin trap agent designed specifically to form stable adducts with oxygen free radicals in electron spin resonance studies, can dramatically reduce te vulnerability of the heart to reperfusion-induced arrhythmias. Studied in concentrations ranging from 10 to 500 μmol/L, DMPO exerted a dose-dependent protective effect. Thus, after 30 minutes of global ischemia, the incidence of ventricular fibrillation (total) and tachycardia was reduced from control values of 100% and 100% to 100% and 100%, 91% and 100%, 25% (p < 0.001) and 50%(p < 0.05), and 25% (p < 0.001) and 41% (p < 0.05), respectively, with DMPO concentrations of 10, 30, 100, and 500 μmol/L. Maximum signals of DMPO-OH adduct, with the use of electron spin resonance studies, were observed after 3 minutes of reperfusion in fibrillated hearts but were not detected in nonfibrillated hearts. Results of nuclear magnetic resonance studies of myocardial adenosine triphosphate, creatine phosphate, pH, and inorganic phosphate showed that these parameters were not significantly changed by treatment with DMPO, and consequently myocardial heart function was not improved, although there was a dissociation between myocardial adenosine triphosphate content and left ventricular developed pressure during reperfusion. The data presented here indicate that oxygen free radicals play an important role in the development of reperfusion-induced arrhythmias but trapping these cytotoxic free radicals does not improve the recovery of postischemic heart function and high-energy phosphate contents in isolated working guinea pig hearts.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hearse, DJ
AU  - Tósaki, Árpád
TI  - Free radicals and reperfusion-induced arrhythmias: protection by spin trap agent PBN in the rat heart
JF  - CIRCULATION RESEARCH
J2  - CIRC RES
VL  - 60
PY  - 1987
IS  - 3
SP  - 375
EP  - 383
PG  - 9
SN  - 0009-7330
UR  - https://m2.mtmt.hu/api/publication/1163549
ID  - 1163549
LA  - English
DB  - MTMT
ER  -