@article{MTMT:107901,
	title = {Immunostaining for substance P receptor labels GABAergic cells with distinct termination patterns in the hippocampus},
	url = {https://m2.mtmt.hu/api/publication/107901},
	author = {Acsády, László and Katona, István and Gulyás, Attila and Shigemoto, R and Freund, Tamás},
	doi = {10.1002/(SICI)1096-9861(19970217)378:3<320::AID-CNE2>3.0.CO;2-5},
	journal-iso = {J COMP NEUROL},
	journal = {JOURNAL OF COMPARATIVE NEUROLOGY},
	volume = {378},
	unique-id = {107901},
	issn = {0021-9967},
	year = {1997},
	eissn = {1096-9861},
	pages = {320-336},
	orcid-numbers = {Gulyás, Attila/0000-0003-4961-636X}
}

@article{MTMT:107892,
	title = {Disinhibition of rat hippocampal pyramidal cells by GABAergic afferents from the septum},
	url = {https://m2.mtmt.hu/api/publication/107892},
	author = {Tóth, Katalin and Freund, Tamás and Miles, R},
	doi = {10.1113/jphysiol.1997.sp022033},
	journal-iso = {J PHYSIOL-LONDON},
	journal = {JOURNAL OF PHYSIOLOGY-LONDON},
	volume = {500},
	unique-id = {107892},
	issn = {0022-3751},
	year = {1997},
	eissn = {1469-7793},
	pages = {463-474}
}

@article{MTMT:107952,
	title = {Correlated morphological and neurochemical features identify different subsets of vasoactive intestinal polypeptide-immunoreactive interneurons in rat hippocampus},
	url = {https://m2.mtmt.hu/api/publication/107952},
	author = {Acsády, László and Arabadzisz, Dimitrula and Freund, Tamás},
	doi = {10.1016/0306-4522(95)00610-9},
	journal-iso = {NEUROSCIENCE},
	journal = {NEUROSCIENCE},
	volume = {73},
	unique-id = {107952},
	issn = {0306-4522},
	year = {1996},
	eissn = {1873-7544},
	pages = {299-315}
}

@article{MTMT:210681,
	title = {Different populations of vasoactive intestinal polypeptide-immunoreactive interneurons are specialized to control pyramidal cells or interneurons in the hippocampus},
	url = {https://m2.mtmt.hu/api/publication/210681},
	author = {Acsády, László and Görcs Tamás, Jenő and Freund, Tamás},
	doi = {10.1016/0306-4522(95)00609-5},
	journal-iso = {NEUROSCIENCE},
	journal = {NEUROSCIENCE},
	volume = {73},
	unique-id = {210681},
	issn = {0306-4522},
	year = {1996},
	eissn = {1873-7544},
	pages = {317-334}
}

@article{MTMT:107931,
	title = {Interneurons of the hippocampus},
	url = {https://m2.mtmt.hu/api/publication/107931},
	author = {Freund, Tamás and Buzsáki, György},
	doi = {10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I},
	journal-iso = {HIPPOCAMPUS},
	journal = {HIPPOCAMPUS},
	volume = {6},
	unique-id = {107931},
	issn = {1050-9631},
	year = {1996},
	eissn = {1098-1063},
	pages = {347-470}
}

@article{MTMT:107722,
	title = {Interneurons containing calretinin are specialized to control other interneurons in the rat hippocampus},
	url = {https://m2.mtmt.hu/api/publication/107722},
	author = {Gulyás, Attila and Hájos, Norbert and Freund, Tamás},
	doi = {10.1523/jneurosci.16-10-03397.1996},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {16},
	unique-id = {107722},
	issn = {0270-6474},
	year = {1996},
	eissn = {1529-2401},
	pages = {3397-3411},
	orcid-numbers = {Gulyás, Attila/0000-0003-4961-636X}
}

@article{MTMT:107951,
	title = {Target selectivity and neurochemical characteristics of VIP-immunoreactive interneurons in the rat dentate gyrus},
	url = {https://m2.mtmt.hu/api/publication/107951},
	author = {Hájos, Norbert and Acsády, László and Freund, Tamás},
	doi = {10.1111/j.1460-9568.1996.tb01604.x},
	journal-iso = {EUR J NEUROSCI},
	journal = {EUROPEAN JOURNAL OF NEUROSCIENCE},
	volume = {8},
	unique-id = {107951},
	issn = {0953-816X},
	year = {1996},
	eissn = {1460-9568},
	pages = {1415-1431}
}

@article{MTMT:1446619,
	title = {Synaptic target selectivity and input of GABAergic basket and bistratified interneurons in the CA1 area of the rat hippocampus},
	url = {https://m2.mtmt.hu/api/publication/1446619},
	author = {Halasy, Katalin and Buhl, EH and Lőrinczi, Zoltán and Tamás, Gábor and Somogyi, Péter Pál},
	doi = {10.1002/(SICI)1098-1063(1996)6:3<306::AID-HIPO8>3.0.CO;2-K},
	journal-iso = {HIPPOCAMPUS},
	journal = {HIPPOCAMPUS},
	volume = {6},
	unique-id = {1446619},
	issn = {1050-9631},
	abstract = {To assess the position of interneurons in the hippocampal network, fast spiking cells were recorded intracellularly in vitro and filled with biocytin. Sixteen non-principal cells were selected on the basis of 1) cell bodies located in the pyramidal layer and in the middle of the slice, 2) extensive labeling of their axons, and 3) a branching pattern of the axon indicating that they were not axo-axonic cells. Examination of their efferent synapses (n = 400) demonstrated that the cells made synapses on cell bodies, dendritic shafts, spines, and axon initial segments (AIS), Statistical analysis of the distribution of different postsynaptic elements, together with published data (n = 288) for 12 similar cells, showed that the interneurons were heterogeneous with regard to the frequency of synapses given to different parts of pyramidal cells. When the cells were grouped according to whether they had less or more than 40% somatic synaptic targets, each population appeared homogeneous. The population (n = 19) innervating a high proportion of somata (53 +/- 10%, SD) corresponds to basket cells. They also form synapses with proximal dendrites (44 +/- 12%) and rarely with AISs and spines. One well-filled basket cell had 8,859 boutons within the slice, covering an area of 0.331 mm(2) of pyramidal layer tangentially and containing 7,150 pyramidal cells, 933 (13%) of which were calculated to be innervated, assuming that each pyramidal cell received nine to ten synapses. It was extrapolated that the intact axon probably had about 10,800 boutons innervating 1,140 pyramids. The proportion of innervated pyramidal cells decreased from 28% in the middle to 4% at the edge of the axonal field. The other group of neurons, the bistratified cells (n = 9), showed a preference for dendritic shafts (79 +/- 8%) and spines (17 +/- 8%) as synaptic targets, rarely terminating on somata (4 +/- 8%). Their axonal field was significantly larger (1,250 +/- 180 mu m) in the medio-lateral direction than that of basket cells (760 +/- 130 mu m). The axon terminals of bistratified cells were smaller than those of basket cells. Furthermore, in contrast to bistratified cells, basket cells had a significant proportion of dendrites in stratum lacunosum-moleculare suggesting a direct entorhinal input. The results define two distinct types of GABAergic neuron innervating pyramidal cells in a spatially segregated manner and predict different functions for the two inputs. The perisomatic termination of basket cells is suited for the synchronization of a subset of pyramidal cells that they select from the population within their axonal field, whereas the termination of bistratified cells in conjunction with Schaffer collateral/commissural terminals may govern the timing of CA3 input and/or voltage-dependent conductances in the dendrites. (C) 1996 Wiley-Liss, Inc.},
	year = {1996},
	eissn = {1098-1063},
	pages = {306-329},
	orcid-numbers = {Tamás, Gábor/0000-0002-7905-6001}
}

@article{MTMT:107721,
	title = {Differences between somatic and dendritic inhibition in the hippocampus},
	url = {https://m2.mtmt.hu/api/publication/107721},
	author = {Miles, R and Tóth, Katalin and Gulyás, Attila and Hájos, Norbert and Freund, Tamás},
	doi = {10.1016/S0896-6273(00)80101-4},
	journal-iso = {NEURON},
	journal = {NEURON},
	volume = {16},
	unique-id = {107721},
	issn = {0896-6273},
	year = {1996},
	eissn = {1097-4199},
	pages = {815-823},
	orcid-numbers = {Gulyás, Attila/0000-0003-4961-636X}
}

@article{MTMT:108775,
	title = {Differential synaptic localization of two major γ-aminobutyric acid type A receptor α subunits on hippocampal pyramidal cells},
	url = {https://m2.mtmt.hu/api/publication/108775},
	author = {Nusser, Zoltán and Sieghart, W and Benke, D and Fritschy, JM and Somogyi, Péter Pál},
	doi = {10.1073/pnas.93.21.11939},
	journal-iso = {P NATL ACAD SCI USA},
	journal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
	volume = {93},
	unique-id = {108775},
	issn = {0027-8424},
	year = {1996},
	eissn = {1091-6490},
	pages = {11939-11944}
}

@article{MTMT:2138101,
	title = {The gamma 2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the alpha 1 and beta 2/3 subunits in hippocampus, cerebellum and globus pallidus.},
	url = {https://m2.mtmt.hu/api/publication/2138101},
	author = {Somogyi, Péter Pál and Fritschy, JM and Benke, D and Roberts, JD and Sieghart, W},
	doi = {10.1016/S0028-3908(96)00086-X},
	journal-iso = {NEUROPHARMACOLOGY},
	journal = {NEUROPHARMACOLOGY},
	volume = {35},
	unique-id = {2138101},
	issn = {0028-3908},
	abstract = {The gamma 2 subunit is necessary for the expression of the full benzodiazepine pharmacology of GABAA receptors and is one of the major subunits in the brain. In order to determine the location of channels containing the gamma 2 subunit in relation to GABA-releasing terminals on the surface of neurons, a new polyclonal antipeptide antiserum was developed to the gamma 2 subunit and used in high resolution, postembedding, immunoelectron-microscopic procedures. Dual immunogold labelling of the same section for two subunits, and up to three sections of the same synapse reacted for different subunits, were used to characterize the subunit composition of synaptic receptors. The gamma 2 subunit was present in type 2, "symmetrical" synapses in each of the brain areas studied, with the exception of the granule cell layer of the cerebellum. The gamma 2 subunit was frequently co-localized in the same synaptic junction with the alpha 1 and beta 2/3 subunits. The immunolabelling of synapses was coincident with the junctional membrane specialization of the active zone. Immunolabelling for the receptor often occurred in multiple clusters in the synapses. In the hippocampus, the gamma 2 subunit was present in basket cell synapses on the somata and proximal dendrites and in axo-axonic cell synapses on the axon initial segment of pyramidal and granule cells. Some synapses on the dendrites of GABAergic interneurones were densely labelled for the gamma 2, alpha 1 and beta 2/3 subunits. In the cerebellum, the gamma 2 subunit was present in both distal and proximal Purkinje cell dendritic synapses established by stellate and basket cell, respectively. On the soma of Purkinje cells, basket cell synapses were only weakly labelled. Synapses on interneuron dendrites were more densely labelled for the gamma 2, alpha 1 and beta 2/3 subunits than synapses on Purkinje or granule cells. Although immunoperoxidase and immunofluorescence methods show an abundance of the gamma 2 subunit in granule cells, the labelling of Golgi synapses was much weaker with the immunogold method than that of the other cell types. In the globus pallidus, many type 2 synapses were labelled for the gamma 2 subunit together with alpha 1 and beta 2/3 subunits. The results show that gamma 2 and beta 2/3 subunits receptor channels are highly concentrated in GABAergic synapses that also contain the alpha 1 and beta 2/3 subunits. Channels containing the gamma 2 subunit are expressed in synapses on functionally distinct domains of the same neuron receiving GABA from different presynaptic sources. There are quantitative differences in the density of GABAA receptors at synapses on different cell types in the same brain area.},
	keywords = {Animals; immunohistochemistry; RATS; Microscopy, Electron; Synapses/*metabolism/ultrastructure; Blotting, Western; Antibody Specificity; Receptors, GABA-A/*metabolism; Hippocampus/*metabolism/ultrastructure; Cell Membrane/metabolism/ultrastructure; Plastic Embedding; Neurons/metabolism/ultrastructure; Intercellular Junctions/*metabolism/ultrastructure; Globus Pallidus/*metabolism/ultrastructure; Cerebellum/*metabolism/ultrastructure},
	year = {1996},
	eissn = {1873-7064},
	pages = {1425-1444}
}

@article{MTMT:107793,
	title = {Synaptic input of horizontal interneurons in striatum oriens of the hippocampal CA1 subfield: Structural basis of feed-back activation},
	url = {https://m2.mtmt.hu/api/publication/107793},
	author = {Blasco-Ibanez, Jose Miguel and Freund, Tamás},
	doi = {10.1111/j.1460-9568.1995.tb00638.x},
	journal-iso = {EUR J NEUROSCI},
	journal = {EUROPEAN JOURNAL OF NEUROSCIENCE},
	volume = {7},
	unique-id = {107793},
	issn = {0953-816X},
	year = {1995},
	eissn = {1460-9568},
	pages = {2170-2180}
}

@article{MTMT:1428428,
	title = {GAMMA (40-100-HZ) OSCILLATION IN THE HIPPOCAMPUS OF THE BEHAVING RAT},
	url = {https://m2.mtmt.hu/api/publication/1428428},
	author = {BRAGIN, A and Jandó, Gábor and Nádasdy, Zoltán and HETKE, J and WISE, K and Buzsáki, György},
	doi = {10.1523/jneurosci.15-01-00047.1995},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {15},
	unique-id = {1428428},
	issn = {0270-6474},
	abstract = {The cellular generation and spatial distribution of gamma frequency (40-100 Hz) activity was examined in the hippocampus of the awake rat. Field potentials and unit activity were recorded by multiple site silicon probes (5- and 16-site shanks) and wire electrode arrays. Gamma waves were highly coherent along the long axis of the dentate hilus, but average coherence decreased rapidly in the CA3 and CA1 directions. Analysis of short epochs revealed large fluctuations in coherence values between the dentate and CA1 gamma waves, Current source density analysis revealed large sinks and sources in the dentate gyrus with spatial distribution similar to the dipoles evoked by stimulation of the perforant path, The frequency changes of gamma and theta waves positively correlated (40-100 Hz and 5-10 Hz, respectively), Putative interneurons in the dentate gyrus discharged at gamma frequency and were phase-locked to the ascending part of the gamma waves recorded from the hilus, Following bilateral lesion of the entorhinal cortex the power and frequency of hilar gamma activity significantly decreased or disappeared. Instead, a large amplitude but slower gamma pattern (25-50 Hz) emerged in the CA3-CA1 network, We suggest that gamma oscillation emerges from an interaction between intrinsic oscillatory properties of interneurons and the network properties of the dentate gyrus. We also hypothesize that under physiological conditions the hilar gamma oscillation may be entrained by the entorhinal rhythm and that gamma oscillation in the CA3-CA1 circuitry is suppressed by either the hilar region or the entorhinal cortex.},
	keywords = {BEHAVIOR; CELLS; NEURONS; hippocampus; EEG; FIELD POTENTIALS; Theta; THETA-RHYTHM; FREELY-MOVING RATS; dentate gyrus; SYNCHRONIZATION; CAT VISUAL-CORTEX; SOURCE DENSITY ANALYSIS; HILAR REGION; 40 HZ; GAMMA OSCILLATION; UNIT ACTIVITY},
	year = {1995},
	eissn = {1529-2401},
	pages = {47-60},
	orcid-numbers = {Nádasdy, Zoltán/0000-0002-6515-9683}
}

@article{MTMT:1661000,
	title = {SYNCHRONIZATION OF NEURONAL-ACTIVITY IN HIPPOCAMPUS BY INDIVIDUAL GABAERGIC INTERNEURONS},
	url = {https://m2.mtmt.hu/api/publication/1661000},
	author = {COBB, SR and BUHL, EH and Halasy, Katalin and PAULSEN, O and Somogyi, Péter Pál},
	doi = {10.1038/378075a0},
	journal-iso = {NATURE},
	journal = {NATURE},
	volume = {378},
	unique-id = {1661000},
	issn = {0028-0836},
	abstract = {SYNCHRONIZATION Of neuronal activity is fundamental in the operation of cortical networks(1). With respect to an ongoing synchronized oscillation, the precise timing of action potentials is an attractive candidate mechanism for information coding(2-5) Networks of inhibitory interneurons have been proposed to have a role in entraining cortical, synchronized 40-Hz activity(6,7). Here we demonstrate that individual GABAergic interneurons(8) can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at theta frequencies (4-7 Hz). The efficiency of this entrainment is due to interaction of GABA(A)-receptor-mediated hyperpolarizing synaptic events with intrinsic oscillatory mechanisms tuned to this frequency range in pyramidal cells. Moreover, this GABAergic mechanism is sufficient to synchronize the firing of pyramidal cells. Thus, owing to the divergence of each GABAergic interneuron(9,10), more than a thousand pyramidal cells may share a common temporal reference established by an individual interneuron.},
	year = {1995},
	eissn = {1476-4687},
	pages = {75-78}
}

@article{MTMT:108528,
	title = {Immunocytochemical localization of the α1 and β2/3 subunits of the GABA~A receptor in relation to specific GABAergic synapses in the dentate gyrus},
	url = {https://m2.mtmt.hu/api/publication/108528},
	author = {Nusser, Zoltán and Roberts, JDB and Baude, A and Richards, JG and Sieghart, W and Somogyi, Péter Pál},
	doi = {10.1111/j.1460-9568.1995.tb00667.x},
	journal-iso = {EUR J NEUROSCI},
	journal = {EUROPEAN JOURNAL OF NEUROSCIENCE},
	volume = {7},
	unique-id = {108528},
	issn = {0953-816X},
	year = {1995},
	eissn = {1460-9568},
	pages = {630-646}
}

@article{MTMT:3301452,
	title = {Hippocampal CA1 interneurons: an in vivo intracellular labeling study.},
	url = {https://m2.mtmt.hu/api/publication/3301452},
	author = {Sík, Attila and Penttonen, M and Ylinen, A and Buzsaki, G},
	doi = {10.1523/jneurosci.15-10-06651.1995},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {15},
	unique-id = {3301452},
	issn = {0270-6474},
	abstract = {Fast spiking interneurons in the CA1 area of the dorsal hippocampus were recorded from and filled with biocytin in anesthetized rats. The full extent of their dendrites and axonal arborizations as well as their calcium binding protein content were examined. Based on the spatial extent of axon collaterals, local circuit cells (basket and O-LM neurons) and long-range cells (bistratified, trilaminar, and backprojection neurons) could be distinguished. Basket cells were immunoreactive for parvalbumin and their axon collaterals were confined to the pyramidal layer. A single basket cell contacted more than 1500 pyramidal neurons and 60 other parvalbumin-positive interneurons. Commissural stimulation directly discharged basket cells, followed by an early and late IPSPs, indicating interneuronal inhibition of basket cells. The dendrites of another local circuit neuron (O-LM) were confined to stratum oriens and it had a small but high-density axonal terminal field in stratum lacunosum-moleculare. The fastest firing cell of all interneurons was a calbindin-immunoreactive bistratified neuron with axonal targets in stratum oriens and radiatum. Two neurons with their cell bodies in the alveus innervated the CA3 region (backprojection cells), in addition to rich axon collaterals in the CA1 region. The trilaminar interneuron had axon collaterals in strata radiatum, oriens and pyramidale with its dendrites confined to stratum oriens. Commissural stimulation evoked an early EPSP-IPSP-late depolarizing potential sequence in this cell. All interneurons formed symmetric synapses with their targets at the electron microscopic level. These findings indicate that interneurons with distinct axonal targets have differential functions in shaping the physiological patterns of the CA1 network.},
	keywords = {Animals; RATS; Hippocampus/cytology/*physiology; Microscopy, Electron; Interneurons/*physiology/ultrastructure; Axons/ultrastructure; Nerve Tissue Proteins/metabolism; Rats, Sprague-Dawley; Lysine/analogs & derivatives; Electrophysiology; Parvalbumins/metabolism; Calbindins; S100 Calcium Binding Protein G/metabolism; Intracellular Membranes/metabolism/ultrastructure},
	year = {1995},
	eissn = {1529-2401},
	pages = {6651-6665}
}

@article{MTMT:2941572,
	title = {CA2+-DEPENDENT PLASTICITY OF MINIATURE INHIBITORY POSTSYNAPTIC CURRENTS AFTER AMPUTATION OF DENDRITES IN CENTRAL NEURONS},
	url = {https://m2.mtmt.hu/api/publication/2941572},
	author = {Soltesz, Ivan and MODY, I},
	journal-iso = {J NEUROPHYSIOL},
	journal = {JOURNAL OF NEUROPHYSIOLOGY},
	volume = {73},
	unique-id = {2941572},
	issn = {0022-3077},
	abstract = {1. The effects of cutting off the bulk (>2/3) of the dendritic tree (dendrotomy) on GABAergic miniature inhibitory postsynaptic currents (mIPCSs) were studied in granule cells of the adult rat dentate gyrus in 400-mu m-thick slices in vitro. 2. After dendrotomy carried out in warm (32 degrees C) control artificial cerebrospinal fluid (ACSF), only small antidromic population spikes could be evoked in the granule cell layer, and no viable whole cell recordings could be obtained. However, when dendrotomy was performed in cold (8-10 degrees C) control ACSF, the amplitude of the antidromic population spikes increased, and stable whole cell recordings became possible. 3. Whole cell recordings, with CsCl-filled pipettes, from granule cells dendrotomized in cold control ACSF, revealed significant alterations, lasting >10 h, in the decay kinetics of mIPSCs. The change consisted of a calcium-dependent transformation of the normal, single exponential decay into a prolonged double exponential that effectively increased the charge transferred by the synaptic events (the total area of the currents) by 67%. When 30 mM 1,2 bis-(2-aminophenoxy)-N,N,N',N'-tetraacetic acid (BAPTA) was included in the pipette, the changes in the mIPSCs decay kinetics could still be observed after dendrotomy, indicating that the maintenance phase of this plasticity did not depend on elevated intracellular calcium levels. 4. Viable whole cell recordings could also be obtained in dendrotomized granule cells when the amputation of dendrites was carried out at 32 degrees C after incubation for 2 h with the cell-permeant Ca2+ chelator, BAPTA-AM (50 mu M), or the cutting process was done in an ACSF containing either a combination of excitatory amino acid receptor antagonists 2-amino-5-phosphonovaleric acid (APV; 25 mu M) + 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 10 mu M), a blocker of intracellular Ca2+ release dantrolene-Na (20 mu M), or the voltage-gated Na+ channel blocker tetrodotoxin (TTX; 1 mu M). 5. After dendrotomy in BAPTA-AM, APV + CNQX, APV + CNQX + TTX, and/or dantrolene, the changes in decay kinetics were prevented, indicating that a rise in intracellular Ca2+ concentration plays a pivotal role in this plasticity. 6. Computer simulations of mIPSCs suggested that changes in single channel kinetics alone can, in principle, account for the Ca2+-dependent changes in mIPSC decay kinetics. 7. These findings are consistent with a lasting Ca2+-dependent increase in gamma-aminobutyric acid-A (GABAA) receptor function in cells that survive physical injury to their dendrites.},
	keywords = {PHOSPHORYLATION; INTRACELLULAR CALCIUM; CA2+; HIPPOCAMPAL-NEURONS; DEPENDENT PROTEIN-KINASE; dentate gyrus; CEREBRAL CORTICAL-NEURONS; GABAA-RECEPTOR FUNCTION; CEREBELLAR PURKINJE-CELLS; GYRUS GRANULE CELLS},
	year = {1995},
	eissn = {1522-1598},
	pages = {1763-1773}
}

@article{MTMT:1660995,
	title = {DIVERSE SOURCES OF HIPPOCAMPAL UNITARY INHIBITORY POSTSYNAPTIC POTENTIALS AND THE NUMBER OF SYNAPTIC RELEASE SITES},
	url = {https://m2.mtmt.hu/api/publication/1660995},
	author = {BUHL, EH and Halasy, Katalin and Somogyi, Péter Pál},
	doi = {10.1038/368823a0},
	journal-iso = {NATURE},
	journal = {NATURE},
	volume = {368},
	unique-id = {1660995},
	issn = {0028-0836},
	abstract = {Dual intracellular recordings from microscopically identified neurons in the hippocampus reveal that the synaptic terminals of three morphologically distinct types of interneuron act through GABA(A) receptors. Each type of interneuron forms up to 12 synaptic contacts with a postsynaptic principal neuron, but each interneuron innervates a different domain of the surface of the postsynaptic neuron. Different kinetics of the postsynaptic effects, together with the strategic placement of synapses, indicate that these GABAergic interneurons serve distinct functions in the cortical network.},
	year = {1994},
	eissn = {1476-4687},
	pages = {823-828}
}

@article{MTMT:3301454,
	title = {Inhibitory CA1-CA3-hilar region feedback in the hippocampus.},
	url = {https://m2.mtmt.hu/api/publication/3301454},
	author = {Sík, Attila and Ylinen, A and Penttonen, M and Buzsaki, G},
	doi = {10.1126/science.8085161},
	journal-iso = {SCIENCE},
	journal = {SCIENCE},
	volume = {265},
	unique-id = {3301454},
	issn = {0036-8075},
	abstract = {The organization of the hippocampus is generally thought of as a series of cell groups that form a unidirectionally excited chain, regulated by localized inhibitory circuits. With the use of in vivo intracellular labeling, histochemical, and extracellular tracing methods, a longitudinally widespread, inhibitory feedback in rat brain from the CA1 area to the CA3 and hilar regions was observed. This long-range, cross-regional inhibition may allow precise synchronization of population activity by timing the occurrence of action potentials in the principal cells and may contribute to the coordinated induction of synaptic plasticity in distributed networks.},
	keywords = {Animals; feedback; RATS; Neural Pathways; *Neural Inhibition; Hippocampus/cytology/*physiology; Interneurons/*physiology/ultrastructure; Dendrites/ultrastructure; Axons/ultrastructure; Membrane Potentials; Pyramidal Cells/*physiology/ultrastructure; Synapses/ultrastructure},
	year = {1994},
	eissn = {1095-9203},
	pages = {1722-1724}
}

@article{MTMT:2941581,
	title = {PATCH-CLAMP RECORDINGS REVEAL POWERFUL GABAERGIC INHIBITION IN DENTATE HILAR NEURONS},
	url = {https://m2.mtmt.hu/api/publication/2941581},
	author = {Soltesz, Ivan and MODY, I},
	doi = {10.1523/jneurosci.14-04-02365.1994},
	journal-iso = {J NEUROSCI},
	journal = {JOURNAL OF NEUROSCIENCE},
	volume = {14},
	unique-id = {2941581},
	issn = {0270-6474},
	abstract = {Whole-cell and cell-attached patch-clamp recordings were used to investigate the nature of GABA(A) receptor-mediated inhibition in the adult rat dentate gyrus in standard 400-mu m-thick horizontal slices. In the presence of the glutamate receptor antagonists D-2-amino-5-phosphonovaleric acid and 6-cyano-7-nitroquinoxaline-2,3-dione, whole-cell voltage-clamp experiments with chloride-filled electrodes ([Cl-](in) = [Cl-](out)) revealed a high degree of spontaneous activity(10-60 Hz) in all hilar neurons (HNs) recorded with access resistances lower than 20 M Omega. The events were inward at negative holding potentials, reversed at around the Cl- equilibrium potential, and were completely abolished by the specific antagonists of the GABA(A) receptor channel picrotoxin and SR-95531 in a reversible manner, indicating that they were spontaneous inhibitory postsynaptic currents (sIPSCs) mediated by GABA(A) receptors. The majority of the slPSCs were TTX-insensitive miniature currents resulting from the action potential-independent release of GABA. The 10-90% rise times and the monoexponential decay time constants of the sIPSCs were significantly longer in HNs than those found in neighboring granule cells (GCs). Furthermore, the decay time constant of the hilar slPSCs was not voltage dependent, contrary to the voltage dependency of the decay time constant of the sIPSCs recorded from GCs. As HNs have longer electrotonic length than GCs do, dendritic filtering may contribute to the kinetic differences. Nonstationary fluctuation analysis showed that whereas the number of channels open at the peak of individual sIPSCs was similar, the single-channel conductances significantly differed between the two cell groups. The 21% smaller single-channel conductance and the existence of electrotonically close GABAergic synapses on HNs indicate that dendritic filtering alone cannot explain the differences between HNs and GCs. The distinct subunit composition of the GABA(A) receptor channels in HNs and GCs may also be responsible for the altered kinetics of IPSCs in HNs. However, the subunit specific benzodiazepine agonist zolpidem (3 mu M) prolonged the monoexponential decay time constants in both HNs and GCs. Thus, differences between the GABA(A) receptors of the two cell types are not due to a simple all-or-none presence/absence of the alpha 5 subunit. In order to determine the effect of the activation of GABA(A) receptors on the resting membrane potential in HNs and GCs in a nonintrusive way, we used single potassium channels as transmembrane voltage sensors by measuring the change in their conductance in cell-attached recordings in response to the GABA(A) agonist muscimol. GABA(A) receptor activation resulted in a strong peak depolarization (about 16 mV) in GCs but induced only small (about 4 mV) depolarizations in HNs. These results reveal for the first time that spontaneous activation of GABA(A) receptors takes place in HNs with a high frequency. Thus, while significant differences exist in the way GABAergic inhibition operates in the two neighboring neuronal population, it is highly unlikely that a general lack of inhibition can explain the extreme vulnerability of HNs to excitotoxic insults.},
	keywords = {HIPPOCAMPAL-NEURONS; GABA-A RECEPTORS; THETA-RHYTHM; dentate gyrus; SYNCHRONIZATION; excitotoxicity; potassium channel; SYNAPTIC CONNECTIONS; patch clamp; granule cell; Hilus; POSTSYNAPTIC CURRENTS; GABA(A) receptor; CURRENT FLUCTUATIONS; perforant path; MOSSY CELLS; subunit composition; INHIBITORY POSTSYNAPTIC CURRENT; GYRUS GRANULE CELLS},
	year = {1994},
	eissn = {1529-2401},
	pages = {2365-2376}
}

@article{MTMT:107599,
	title = {Precision and variability in postsynaptic target selection of inhibitory cells in the hippocampal CA3 region},
	url = {https://m2.mtmt.hu/api/publication/107599},
	author = {Gulyás, Attila and Miles, R and Hájos, Norbert and Freund, Tamás},
	doi = {10.1111/j.1460-9568.1993.tb00240.x},
	journal-iso = {EUR J NEUROSCI},
	journal = {EUROPEAN JOURNAL OF NEUROSCIENCE},
	volume = {5},
	unique-id = {107599},
	issn = {0953-816X},
	year = {1993},
	eissn = {1460-9568},
	pages = {1729-1751},
	orcid-numbers = {Gulyás, Attila/0000-0003-4961-636X}
}

@article{MTMT:2138105,
	title = {A high degree of spatial selectivity in the axonal and dendritic domains of physiologically identified local-circuit neurons in the dentate gyrus of the rat hippocampus. A High Degree of Spatial Selectivity in the Axonal and Dendritic Domains of Physiologically Identified Local‐circuit Neurons in the Dentate Gyms of the Rat Hippocampus},
	url = {https://m2.mtmt.hu/api/publication/2138105},
	author = {Han, ZS and Buhl, EH and Lőrinczi, Zoltán and Somogyi, Péter Pál},
	doi = {10.1111/j.1460-9568.1993.tb00507.x},
	journal-iso = {EUR J NEUROSCI},
	journal = {EUROPEAN JOURNAL OF NEUROSCIENCE},
	volume = {5},
	unique-id = {2138105},
	issn = {0953-816X},
	abstract = {The axonal and dendritic domains of neurons with extensive, locally arborizing axons were delineated in the dentate gyrus of the rat hippocampus. In horizontally cut slice preparations neurons were briefly recorded and subsequently filled with biocytin when one or several of the following physiological properties were observed: (i) high-amplitude short-latency spike afterhyperpolarization; (ii) lack of spike frequency adaptation; (iii) high firing rate in response to depolarizing current. In a sample of 14 neurons, sufficient dendritic and/or axonal detail was recovered to identify them as non-principal cells, i.e. non-granule, non-mossy cells. Five distinct types of cells were recognized, based on the spatial distribution of dendrites, presumably reflecting the availability of afferents, and on the basis of the highly selective distribution of their axon terminals, indicating synaptic target selectivity. They are: (1) the hilar cell forming a dense axonal plexus in the commissural and association pathway terminal field (HICAP cell; horizontal axon extent 1.6 mm) in the inner one-third of the molecular layer, and having dendrites extending from the hilus to the top of the molecular layer; (2) the hilar cell with its axon ramifying in the perforant path terminal field (HIPP cell, horizontal axon extent 2.0 mm) in the outer two-thirds of the molecular layer, whereas its spiny dendrites were restricted to the hilus; (3) the molecular layer cell with its dendritic and axonal domains confined to the perforant path terminal zone (MOPP cell, horizontal extent of axon 2.0 mm); (4) the dentate basket cell (horizontal axon extent 0.9 mm) had most of its axon concentrated in the granule cell layer, the remainder being localized in the inner molecular layer and hilus; (5) the hilar chandelier cell, or axo-axonic cell (horizontal axon extent 1.1 mm), densely innervating the granule cell layer with fascicles of radially oriented terminal rows, and also forming an extensive plexus in the hilus. The three cell types having their somata in the hilus projected to granule cells at the same septo-temporal level where their cell bodies were located. The results demonstrate that there is a spatially selective innervation of the granule cells by at least five distinct types of dentate neurons, which terminate in several instances in mutually exclusive domains. Their dendrites may have access to all (HICAP cell) or only a few (e.g. HIPP and MOPP cell) of the hippocampal afferents. This arrangement provides a framework for independent interaction between the output of local circuit neurons and subsets of excitatory afferents providing input to principal cells.},
	keywords = {Animals; Female; RATS; ARTICLE; Neural Pathways; Lysine/analogs & derivatives; priority journal; controlled study; nonhuman; animal tissue; animal cell; spatial orientation; brain electrophysiology; nerve cell membrane potential; cellular distribution; spike; spike wave; action potential; dentate gyrus; brain tissue; Rats, Wistar; synapse; nerve ending; nerve conduction; cell structure; Cell Shape; nerve fiber; sensory nerve cell; interneuron; Axons/*ultrastructure; cell specificity; Dendrites; hyperpolarization; granule cell; brain nerve cell; Interneurons/physiology/ultrastructure; Dendrites/*ultrastructure; nerve fiber growth; Neural Pathways/physiology/ultrastructure; Neurons/*physiology/*ultrastructure; Hippocampus/*physiology/*ultrastructure; Basket cell; axo‐axonic cell; afterdischarge},
	year = {1993},
	eissn = {1460-9568},
	pages = {395-410}
}

@article{MTMT:2941583,
	title = {LOW-FREQUENCY AND HIGH-FREQUENCY MEMBRANE-POTENTIAL OSCILLATIONS DURING THETA ACTIVITY IN CA1 AND CA3 PYRAMIDAL NEURONS OF THE RAT HIPPOCAMPUS UNDER KETAMINE-XYLAZINE ANESTHESIA},
	url = {https://m2.mtmt.hu/api/publication/2941583},
	author = {Soltesz, Ivan and DESCHENES, M},
	doi = {10.1152/jn.1993.70.1.97},
	journal-iso = {J NEUROPHYSIOL},
	journal = {JOURNAL OF NEUROPHYSIOLOGY},
	volume = {70},
	unique-id = {2941583},
	issn = {0022-3077},
	abstract = {1. Intracellularly recorded low- and high-frequency (4-6 and 25-50 Hz, respectively), rhythmic, spontaneous membrane potential oscillations were investigated in pyramidal neurons of the rat hippocampus in vivo, during theta(THETA, 4-6 Hz)electroencephalographic (EEG) activity, under ketamine-xylazine anesthesia. 2. The EEG activity showed two spectral peaks, one in the THETA range. the other at higher frequencies (25-50 Hz). On the basis of their electrophysiological and pharmacological properties, it was concluded that the EEG THETA-waves, and the fast EEG rhythm, recorded during ketamine-xylazine anesthesia, share the basic properties of those THETA and fast rhythms that are recorded under the effects of other types of anesthetics. 3. When intracellular recordings (n = 32) were made with electrodes filled with potassium-acetate (K-acetate), the only CA1 and CA3 pyramidal cells (PCs) considered for further analysis were those that did not fire rhythmically at most or each cycle of the THETA rhythm at the resting membrane potential. During EEG-THETA, the membrane potential (V(m)) of these cells showed a prominent oscillation (3-15 mV) with frequencies similar to those of the EEG-THETA (the intracellular THETA rhythm, intra-THETA). 4. The frequency of the intra-THETA was independent of the V(m). However, the phase difference between the intra-THETA and the EEG-THETA was voltage dependent in both types of cells. CA1 PCs showed a large ( 120-180-degrees, where 360-degrees is the full cycle), gradual shift in the phase difference between the intra-THETA and the EEG-THETA, when the membrane was hyperpolarized to -85 from -65 mV. Although CA3 PCs displayed a larger variability in their phase-voltage relations. a voltage-dependent phase shift (90-180-degrees) could be observed in CA3 PCs as well. 5. Although the amplitude of the intra-THETA in both CA1 and CA3 PCs could display large, sudden, spontaneous changes at a given V(m), the amplitude-V(m) plots tended to show a minimum between -70 and -80 mV. Spontaneous changes in the amplitude of the intra-THETA did not affect the phase difference between the intra- and the EEG-THETA rhythms. 6. Intracellular injection of QX-314 (50-100 mM) did not change the phase-V(m) or the amplitude-V(m) relationships of CA1 PCs. 7. Intracellular injection of chloride (Cl-) ions greatly reduced the voltage dependency of the phase difference and revealed fast (duration: 20-25 ms), depolarizing potentials (5-20 mV), which appeared at high frequencies (25-50 Hz), amplitude modulated at THETA-frequencies. 8. These findings are consistent with the hypothesis that rhythmic, high-frequency, gamma-aminobutyric acid-A (GABA(A))-receptor-mediated inhibitory postsynaptic potentials have an important role in the generation of both the THETA and the fast hippocampal rhythms.},
	keywords = {CELLS; SLICES; ENTORHINAL CORTEX; INHIBITORY INTERNEURONS; BEHAVING RAT; Urethane; GENERATORS; RHYTHMICAL SLOW ACTIVITY; SYNAPTIC RESPONSES; QX-314},
	year = {1993},
	eissn = {1522-1598},
	pages = {97-116}
}

@article{MTMT:2550096,
	title = {High-frequency network oscillation in the hippocampus},
	url = {https://m2.mtmt.hu/api/publication/2550096},
	author = {Buzsáki, György and Horváth, Zsolt and Urioste, R and Hetke, J and Wise, K},
	doi = {10.1126/science.1589772},
	journal-iso = {SCIENCE},
	journal = {SCIENCE},
	volume = {256},
	unique-id = {2550096},
	issn = {0036-8075},
	year = {1992},
	eissn = {1095-9203},
	pages = {1025-1027}
}

@article{MTMT:107532,
	title = {GABA-containing neurons in the septum control inhibitory interneurons in the hippocampus},
	url = {https://m2.mtmt.hu/api/publication/107532},
	author = {Freund, Tamás and Antal, Miklós},
	doi = {10.1038/336170a0},
	journal-iso = {NATURE},
	journal = {NATURE},
	volume = {336},
	unique-id = {107532},
	issn = {0028-0836},
	keywords = {Animals; RATS; Interneurons/physiology; Hippocampus/cytology/*physiology; gamma-Aminobutyric Acid/*physiology; Neural Inhibition; Afferent Pathways/physiology; Septum Pellucidum/cytology/*physiology; Neurons, Afferent/cytology/physiology},
	year = {1988},
	eissn = {1476-4687},
	pages = {170-173}
}

@article{MTMT:2587252,
	title = {FEEDFORWARD INHIBITION IN THE HIPPOCAMPAL-FORMATION},
	url = {https://m2.mtmt.hu/api/publication/2587252},
	author = {Buzsáki, György},
	doi = {10.1016/0301-0082(84)90023-6},
	journal-iso = {PROG NEUROBIOL},
	journal = {PROGRESS IN NEUROBIOLOGY: AN INTERNATIONAL REVIEW JOURNAL},
	volume = {22},
	unique-id = {2587252},
	issn = {0301-0082},
	year = {1984},
	eissn = {1873-5118},
	pages = {131-153}
}