TY - GEN AU - Csonka, Ákos AU - Harangozó, Márk AU - Gárgyán, István TI - A periprotetikus és periimplantatikusfemur törések ellátása CY - A Magyar Traumatológiai Társaság 56. Kongresszusa 2023-10-11 [Szeged, Magyarország] PY - 2023 UR - https://m2.mtmt.hu/api/publication/34194528 ID - 34194528 LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Gárgyán, István AU - Török, László AU - Ecseri , Tamás TI - A trigen intertan szegezések során tapasztalt Z effektus PY - 2022 UR - https://m2.mtmt.hu/api/publication/32891181 ID - 32891181 N1 - előadás LA - Hungarian DB - MTMT ER - TY - GEN AU - Dózsai, Dávid AU - Gárgyán, István AU - Csonka, Ákos AU - Bodzay, Tamás TI - Atipusos periprotetikus femurtörések összefüggése a hosszútávú biszfoszfonát terápiával PY - 2022 UR - https://m2.mtmt.hu/api/publication/32891171 ID - 32891171 N1 - előadás LA - Hungarian DB - MTMT ER - TY - GEN AU - Ecseri , Tamás AU - Gárgyán, István AU - Török, László AU - Csonka, Ákos TI - A LISS-DF alternatív alkalmazása PY - 2022 UR - https://m2.mtmt.hu/api/publication/32891142 ID - 32891142 N1 - előadás LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gárgyán, István AU - Dózsai, Dávid AU - Csonka, István AU - Rárosi, Ferenc AU - Bodzay, Tamás AU - Csonka, Ákos TI - Bisphosphonate therapy associated with bilateral atypical femoral fracture and delayed union JF - JOINT DISEASES AND RELATED SURGERY J2 - JOINT DIS RELAT SURG VL - 33 PY - 2022 IS - 1 SP - 24 EP - 32 PG - 9 SN - 2687-4784 DO - 10.52312/jdrs.2022.355 UR - https://m2.mtmt.hu/api/publication/32766033 ID - 32766033 LA - English DB - MTMT ER - TY - JOUR AU - Jávor, Péter János AU - Mácsai, Attila AU - Butt, Edina AU - Baráth, Bálint AU - Jász, Dávid Kurszán AU - Horváth, Tamara AU - Baráth, Bence AU - Csonka, Ákos AU - Török, László AU - Varga, Endre AU - Hartmann, Petra TI - Mitochondrial Dysfunction Affects the Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis Differently JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 14 PG - 14 SN - 1661-6596 DO - 10.3390/ijms23147553 UR - https://m2.mtmt.hu/api/publication/32924179 ID - 32924179 AB - There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison of synovial mitochondrial derangements in these main arthritis forms is missing. A prospective clinical study was conducted on adult patients undergoing knee surgery. Patients were allocated into RA and OA groups based on disease-specific clinical scores, while patients without arthritis served as controls. Synovial samples were subjected to high-resolution respirometry to analyze mitochondrial functions. From the total of 814 patients, 109 cases were enrolled into the study (24 RA, 47 OA, and 38 control patients) between 1 September 2019 and 31 December 2021. The decrease in complex I-linked respiration and dyscoupling of mitochondria were characteristics of RA patients, while both arthritis groups displayed reduced OxPhos activity compared to the control group. However, no significant difference was found in complex II-related activity between the OA and RA groups. The cytochrome C release and H2O2 formation were increased in both arthritis groups. Mitochondrial dysfunction was present in both arthritis groups; however, to a different extent. Consequently, mitochondrial protective agents may have major benefits for arthritis patients. Based on our current study, we recommend focusing on respiratory complex I in rheumatoid arthritis research. LA - English DB - MTMT ER - TY - JOUR AU - ABDUR, RAUF AU - SAUD, BAWAZEER AU - MUSLIM, RAZA AU - EMAN, EL-SHARKAWY AU - MD., HABIBUR RAHMAN AU - MOHAMED, A. EL-ESAWI AU - GHIAS, UDDIN AU - BINA, S. SIDDIQUI AU - ANEES, AHMED KHALIL AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána AU - HAROON, KHAN AU - MOHAMMAD, S. MUBARAK AU - TAIBI, BEN HADDA AU - MUDYAWATI, KAMARUDDIN AU - SEEMA, PATEL TI - Reversal of multidrug resistance and antitumor promoting activity of 3-oxo-6β-hydroxy- β-amyrin isolated from Pistacia integerrima JF - BIOCELL J2 - BIOCELL VL - 45 PY - 2021 IS - 1 SP - 139 EP - 147 PG - 9 SN - 0327-9545 DO - 10.32604/biocell.2021.013277 UR - https://m2.mtmt.hu/api/publication/31794441 ID - 31794441 N1 - Export Date: 15 January 2022 CODEN: BOCEE Correspondence Address: BAWAZEER, S.; Department of Pharmaceutical Chemistry, Saudi Arabia; email: ssbawazeer@uqu.edu.sa Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; curcumin, 458-37-7; rhodamine 123, 62669-70-9; verapamil, 152-11-4, 52-53-9 LA - English DB - MTMT ER - TY - JOUR AU - Almási, Nikoletta AU - Murlasits, Zsolt AU - Al-Awar, Amin AU - Csonka, Ákos AU - Dvorácskó, Szabolcs AU - Tömböly, Csaba AU - Török, Szilvia AU - Bester, D. AU - Pósa, Anikó AU - Varga, Csaba AU - Kupai, Krisztina TI - Effects of aging on proteasomal-ubiquitin system, oxidative stress balance and calcium homeostasis in middle-aged female rat colon JF - PHYSIOLOGY INTERNATIONAL J2 - PHYSIOL INT VL - 108 PY - 2021 IS - 1 SP - 27 EP - 42 PG - 16 SN - 2498-602X DO - 10.1556/2060.2021.00012 UR - https://m2.mtmt.hu/api/publication/32128211 ID - 32128211 N1 - Funding Agency and Grant Number: Ministry of Human Capacities, Hungarian grant [GINOP2.3.215201600030]; [203913/2018/FEKUSTRAT] Funding text: This research was supported by GINOP2.3.215201600030 and Ministry of Human Capacities, Hungarian grant 203913/2018/FEKUSTRAT. LA - English DB - MTMT ER - TY - JOUR AU - Bawazeer, Sami AU - Rauf, Abdur AU - Mabkhot, Yahia N. AU - Al-Showiman, Salim S. AU - Patel, Seema AU - Gul, Somia AU - Raza, Muslim AU - Molnár, József AU - Szabó, Diána AU - Csonka, Ákos AU - Mujeeb-ur-, Rehman AU - Mubarak, Mohammad S. AU - Zengin, Gokhan AU - Ramadan, Mohamed Fawzy TI - Isolation of Bioactive Compounds from Pistacia integerrima with Promising Effects on Reverse Cancer Multidrug Resistance JF - RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY J2 - RUSS J BIOORG CHEM+ VL - 47 PY - 2021 IS - 5 SP - 997 EP - 1003 PG - 7 SN - 1068-1620 DO - 10.1134/S1068162021050204 UR - https://m2.mtmt.hu/api/publication/32470529 ID - 32470529 N1 - ACKNOWLEDGMENTS: The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through Research group Project under grant number (R.G.P. 2/26/42). LA - English DB - MTMT ER - TY - GEN AU - Butt, Edina AU - Jávor, Péter János AU - Csonka, Endre AU - Csonka, Ákos AU - Török, László AU - Varga, Endre AU - Hartmann, Petra TI - Synoviális mitokondriumok légzési aktivitásának vizsgálata arthritisben PY - 2021 UR - https://m2.mtmt.hu/api/publication/32305253 ID - 32305253 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Dózsai, Dávid AU - Gárgyán, István AU - Varga, Endre TI - Atípusos femurtörések összefüggése a hosszantartó biszfoszfonát terápiával JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 64 PY - 2021 IS - 1-4 SP - 49 EP - 58 PG - 10 SN - 1217-3231 DO - 10.21755/MTO.2021.064.0104.005 UR - https://m2.mtmt.hu/api/publication/32731979 ID - 32731979 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre TI - Multidisciplinary treatment of a complicated crural degloving injury in a diabetic patient JF - INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED J2 - INJURY VL - 52 PY - 2021 IS - Suppl. 1 SP - S74 EP - S77 SN - 0020-1383 DO - 10.1016/j.injury.2020.02.050 UR - https://m2.mtmt.hu/api/publication/31189807 ID - 31189807 LA - English DB - MTMT ER - TY - GEN AU - Dózsai, Dávid AU - Gárgyán, István AU - Rárosi, Ferenc AU - Csonka, Ákos AU - Varga, Endre AU - Bodzay, Tamás TI - Hosszútávú biszfoszfonát terápia összefüggése a bilaterális atipusos femurtörésekkel és elhúzódó törésgyógyulással: multicenter study PY - 2021 UR - https://m2.mtmt.hu/api/publication/32305203 ID - 32305203 LA - Hungarian DB - MTMT ER - TY - GEN AU - Ecseri , Tamás AU - Gárgyán, István AU - Varga, Endre AU - Csonka, Ákos TI - Egy Volkmann törés tanulsága PY - 2021 UR - https://m2.mtmt.hu/api/publication/32305303 ID - 32305303 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Almási, Nikoletta AU - Török, Szilvia AU - Valkusz, Zsuzsanna AU - Tajti, Máté AU - Csonka, Ákos AU - Murlasits, Zsolt AU - Pósa, Anikó AU - Varga, Csaba AU - Kupai, Krisztina TI - Sigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 9 PY - 2020 IS - 11 PG - 13 SN - 2076-3921 DO - 10.3390/antiox9111081 UR - https://m2.mtmt.hu/api/publication/31652422 ID - 31652422 N1 - Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, H-6726, Hungary Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, H-6720, Hungary Department of Traumatology, University of Szeged, Szeged, H-6725, Hungary Laboratory Animals Research Center, Qatar University, Doha, 2713, Qatar Interdisciplinary Excellence Center, University of Szeged, Szeged, H-6726, Hungary Export Date: 22 November 2020 Correspondence Address: Kupai, K.; Department of Physiology, Anatomy and Neuroscience, University of Szeged, Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of SzegedHungary; email: kupai@bio.u-szeged.hu Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT Funding details: IRCC-2019-09 Funding text 1: Funding: GINOP-2.3.2-15-2016-00030 and Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT. Qatar University International Research Collaboration Grant IRCC-2019-09. Funding text 2: Acknowledgments: This research was supported by GINOP-2.3.2-15-2016-00030 and Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT. The study was also supported by Qatar University International Research Collaboration Grant IRCC-2019-09. Funding Agency and Grant Number: Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]; Qatar University International Research Collaboration Grant [IRCC-2019-09]; [GINOP-2.3.2-15-2016-00030] Funding text: GINOP-2.3.2-15-2016-00030 andMinistry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT. Qatar University International Research Collaboration Grant IRCC-2019-09. Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, H-6726, Hungary Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, H-6720, Hungary Department of Traumatology, University of Szeged, Szeged, H-6725, Hungary Laboratory Animals Research Center, Qatar University, Doha, 2713, Qatar Interdisciplinary Excellence Center, University of Szeged, Szeged, H-6726, Hungary Export Date: 9 March 2021 Correspondence Address: Kupai, K.; Department of Physiology, Hungary; email: kupai@bio.u-szeged.hu Correspondence Address: Kupai, K.; Department of Medicine, Hungary; email: kupai@bio.u-szeged.hu Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT, IRCC-2019-09 Funding text 1: Funding: GINOP-2.3.2-15-2016-00030 and Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT. Qatar University International Research Collaboration Grant IRCC-2019-09. Funding text 2: Acknowledgments: This research was supported by GINOP-2.3.2-15-2016-00030 and Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT. The study was also supported by Qatar University International Research Collaboration Grant IRCC-2019-09. LA - English DB - MTMT ER - TY - JOUR AU - Almási, Nikoletta AU - Török, Szilvia AU - Dvorácskó, Szabolcs AU - Tömböly, Csaba AU - Csonka, Ákos AU - Baráth, Zoltán Lajos AU - Murlasits, Zsolt AU - Valkusz, Zsuzsanna AU - Pósa, Anikó AU - Varga, Csaba AU - Kupai, Krisztina TI - Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis. Modulation of the UCHL-1, IL-6 Pathway TS - Modulation of the UCHL-1, IL-6 Pathway JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 21 PY - 2020 IS - 11 PG - 21 SN - 1661-6596 DO - 10.3390/ijms21114046 UR - https://m2.mtmt.hu/api/publication/31340535 ID - 31340535 N1 - Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, H-6726, Hungary Laboratory of Chemical Biology, Institute of Biochemistry, Biological Research Centre, Szeged, H-6726, Hungary Department of Medical Chemistry, University of Szeged, Szeged, H-6725, Hungary Department of Traumatology, University of Szeged, Szeged, H-6725, Hungary Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, University of Szeged, Szeged, H-6720, Hungary Laboratory Animals Research Center, Qatar University, Doha, 2713, Qatar 1st Department of Medicine, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, H-6720, Hungary Cited By :7 Export Date: 11 April 2022 Correspondence Address: Kupai, K.; Department of Physiology, Hungary; email: kupai@bio.u-szeged.hu Chemicals/CAS: 1 [2 (3,4 dichlorophenyl)ethyl] 4 methylpiperazine, 206996-13-6; endothelial nitric oxide synthase, 503473-02-7; fluvoxamine maleate, 61718-82-9; heme oxygenase, 9059-22-7; inducible nitric oxide synthase, 501433-35-8; ligase, 9080-13-1; myeloperoxidase; salazosulfapyridine, 599-79-1; trinitrobenzenesulfonic acid, 16655-63-3, 2508-19-2; fluvoxamine, 54739-18-3; peroxidase, 9003-99-0; ubiquitin thiolesterase, 86480-67-3; Cytokines; Fluvoxamine; Heme Oxygenase (Decyclizing); Inflammation Mediators; Interleukin-6; Ligands; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; Receptors, sigma; sigma-1 receptor; Trinitrobenzenesulfonic Acid; Ubiquitin Thiolesterase; UCHL1 protein, rat Manufacturers: Sigma Aldrich, Hungary Funding details: National Research, Development and Innovation Office Funding text 1: This research was supported by GINOP-2.3.2-15-2016-00030. S.D. and C.T. were supported by grant K124952 of the National Research, Development and Innovation Office. Funding text 2: Acknowledgments: This research was supported by GINOP-2.3.2-15-2016-00030. S.D. and C.T. were supported by grant K124952 of the National Research, Development and Innovation Office. LA - English DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Dózsai, Dávid AU - Gárgyán, István AU - Ecseri , Tamás AU - Varga, Endre TI - A hosszantartó biszfoszfonát terápia összefüggése az atípusos periprotetikus femur töréssel PY - 2020 UR - https://m2.mtmt.hu/api/publication/31592293 ID - 31592293 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Dózsai, Dávid AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre TI - Atípusos periprotetikus femurtörés JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 63 PY - 2020 IS - 1-4 SP - 49 EP - 57 PG - 8 SN - 1217-3231 DO - 10.21755/MTO.2020.063.0104.006 UR - https://m2.mtmt.hu/api/publication/32032752 ID - 32032752 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Dózsai, Dávid AU - Ecseri , Tamás AU - Csonka, István AU - Gárgyán, István AU - Doró, Péter AU - Csonka, Ákos TI - Atypical periprosthetic femoral fracture associated with long-term bisphosphonate therapy JF - JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH J2 - J ORTHOP SURG RES VL - 15 PY - 2020 IS - 1 PG - 7 SN - 1749-799X DO - 10.1186/s13018-020-01941-x UR - https://m2.mtmt.hu/api/publication/31602868 ID - 31602868 LA - English DB - MTMT ER - TY - GEN AU - Ecseri , Tamás AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre TI - A hosszantartó biszfoszfonát terápia összefüggése az atípusos femurtöréssel PY - 2020 UR - https://m2.mtmt.hu/api/publication/31592299 ID - 31592299 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Nové, Márta AU - Csonka, Ákos AU - Varga, Borisz AU - SANMARTÍN, CARMEN AU - DOMÍNGUEZ-ÁLVAREZ, ENRIQUE AU - Spengler, Gabriella TI - Phenothiazines and Selenocompounds. A Potential Novel Combination Therapy of Multidrug Resistant Cancer TS - A Potential Novel Combination Therapy of Multidrug Resistant Cancer JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 40 PY - 2020 IS - 9 SP - 4921 EP - 4928 PG - 8 SN - 0250-7005 DO - 10.21873/anticanres.14495 UR - https://m2.mtmt.hu/api/publication/31564848 ID - 31564848 N1 - Export Date: 18 January 2021 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of SzegedHungary; email: spengler.gabriella@med.uszeged.hu Chemicals/CAS: chlorpromazine, 50-53-3, 69-09-0; promethazine, 58-33-3, 60-87-7; thioridazine, 130-61-0, 50-52-2; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Organoselenium Compounds; Phenothiazines Manufacturers: Sigma Aldrich Funding details: 3.6.3-VEKOP-16-2017-00009 Funding text 1: The study was supported by the Szeged Foundation for Cancer Research (Szegedi Rákkutatásért Alapítvány). M.N. was supported by EFOP 3.6.3-VEKOP-16-2017-00009. E.D.A. was supported by ‘Iniciativas Ropelanas’ and ‘Asociación Cultural Trevinca’, two associations from Zamora (Spain) that promote cancer research. Cited By :1 Export Date: 3 June 2021 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Hungary; email: spengler.gabriella@med.uszeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Gárgyán, István AU - Csonka, Ákos AU - Ecseri , Tamás TI - The prognostic value of the hip screw position in trochanteric fractures JF - EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY J2 - EUR J TRAUMA EMERG S VL - 46 PY - 2020 SP - S178 EP - S178 PG - 1 SN - 1863-9933 UR - https://m2.mtmt.hu/api/publication/31311960 ID - 31311960 N1 - Kötet DOI: 10.1007/s00068-020-01343-y LA - English DB - MTMT ER - TY - JOUR AU - Kármán, Zoltán AU - Réthi-Nagy, Zsuzsánna AU - Ábrahám, Edit AU - Ördögh, Lilla AU - Csonka, Ákos AU - Vilmos, Péter AU - Debski, Janusz AU - Dadlez, Michal AU - Glover, David M. AU - Lipinszki, Zoltán TI - Novel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase JF - OPEN BIOLOGY J2 - OPEN BIOL VL - 10 PY - 2020 IS - 12 PG - 12 SN - 2046-2441 DO - 10.1098/rsob.200343 UR - https://m2.mtmt.hu/api/publication/31788305 ID - 31788305 N1 - Biological Research Centre, Institute of Biochemistry, Mta Lendület Laboratory of Cell Cycle Regulation, Szeged, H-6726, Hungary Doctoral School of Biology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary Department of Traumatology, University of Szeged, Szeged, H-6726, Hungary Biological Research Centre, Institute of Genetics, Szeged, H-6726, Hungary Laboratory of Mass Spectrometry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 02-106, Poland Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom California Institute of Technology, Pasadena, CA 91125, United States Cited By :1 Export Date: 31 May 2022 Correspondence Address: Lipinszki, Z.; Biological Research Centre, Hungary; email: lipinszki.zoltan@brc.hu AB - Protein phosphatase 4 (PP4) is an evolutionarily conserved and essential Ser/Thr phosphatase that regulates cell division, development and DNA repair in eukaryotes. The major form of PP4, present from yeast to human, is the PP4c-R2-R3 heterotrimeric complex. The R3 subunit is responsible for substrate-recognition via its EVH1 domain. In typical EVH1 domains, conserved phenylalanine, tyrosine and tryptophan residues form the specific recognition site for their target's proline-rich sequences. Here, we identify novel binding partners of the EVH1 domain of the Drosophila R3 subunit, Falafel, and demonstrate that instead of binding to proline-rich sequences this EVH1 variant specifically recognizes atypical ligands, namely the FxxP and MxPP short linear consensus motifs. This interaction is dependent on an exclusively conserved leucine that replaces the phenylalanine invariant of all canonical EVH1 domains. We propose that the EVH1 domain of PP4 represents a new class of the EVH1 family that can accommodate low proline content sequences, such as the FxxP motif. Finally, our data implicate the conserved Smk-1 domain of Falafel in target-binding. These findings greatly enhance our understanding of the substrate-recognition mechanisms and function of PP4. © 2020 The Authors. LA - English DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre TI - Reverz LISS-DF alkalmazása periprotetikus történések ellátása során CY - Kecskemét PY - 2019 UR - https://m2.mtmt.hu/api/publication/30822780 ID - 30822780 N1 - A-0018 LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Varga, Endre TI - Infekciókontroll a szegedi traumatológiai klinikán CY - Szeged, 2019. június 12-14. PY - 2019 UR - https://m2.mtmt.hu/api/publication/30719872 ID - 30719872 N1 - előadás LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos TI - Atípusos femurtörések kezelése PY - 2019 UR - https://m2.mtmt.hu/api/publication/30719868 ID - 30719868 N1 - előadás LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Kovács, Mihály AU - Gárgyán, István AU - Horváth, Attila AU - Varga, Endre TI - Nehézségek az osteoporoticus humerus törések ellátásában PY - 2019 SP - 8 UR - https://m2.mtmt.hu/api/publication/30705023 ID - 30705023 N1 - ELŐADÁS LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Dózsai, Dávid AU - Gárgyán, István AU - Csonka, István AU - Ecseri , Tamás AU - Varga, Endre TI - Mellkasi sérültek drenázsadatainak vizsgálata PY - 2019 SP - 6 UR - https://m2.mtmt.hu/api/publication/30705018 ID - 30705018 N1 - ELŐADÁS LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Ecseri , Tamás AU - Dózsai, Dávid AU - Csonka, István AU - Gárgyán, István AU - Varga, Endre TI - A combfejcsavar helyzetének prognosztikai jelentősége a csípőtáji törések esetén [The prognostic value of the hip screw position in intertrochanteric fractures] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 160 PY - 2019 IS - 9 SP - 338 EP - 342 PG - 5 SN - 0030-6002 DO - 10.1556/650.2019.31328 UR - https://m2.mtmt.hu/api/publication/30466023 ID - 30466023 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Dózsai, Dávid AU - Ecseri , Tamás AU - Gárgyán, István AU - Csonka, István AU - Varga, Endre TI - Mellkasi sérültek drenázsadatainak vizsgálata [Drainage data analysis of chest-injured patients] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 160 PY - 2019 IS - 5 SP - 172 EP - 178 PG - 7 SN - 0030-6002 DO - 10.1556/650.2019.31252 UR - https://m2.mtmt.hu/api/publication/30418766 ID - 30418766 LA - Hungarian DB - MTMT ER - TY - GEN AU - Dózsai, Dávid AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre TI - Mellkascsövezés komplikációi és megoldásai mellkasi sérülések esetén CY - Kecskemét PY - 2019 UR - https://m2.mtmt.hu/api/publication/30822776 ID - 30822776 N1 - A-0011 LA - Hungarian DB - MTMT ER - TY - GEN AU - Tóth, Zoltán AU - Csonka, Ákos AU - Varga, Endre TI - Tibia álízületek kezelése Klinikánkon PY - 2019 SP - 12 UR - https://m2.mtmt.hu/api/publication/30705024 ID - 30705024 N1 - ELŐADÁS LA - Hungarian DB - MTMT ER - TY - JOUR AU - Cyboran-Mikolajczyk, S AU - Csonka, Ákos AU - Molnár, József AU - Szabó, Diána AU - Oszmianski, J AU - Kleszczynska, H TI - In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta JF - POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES J2 - POLISH J FOOD NUTR SCI VL - 68 PY - 2018 IS - 2 SP - 171 EP - 177 PG - 7 SN - 1230-0322 DO - 10.1515/pjfns-2017-0021 UR - https://m2.mtmt.hu/api/publication/3341125 ID - 3341125 N1 - This work was supported from funds of the statutory activities of the Department of Physics and Biophysics, Wroclaw University of Environmental and Life Sciences. The study was also supported by Szeged Foundation for Cancer Research, by the project TAMOP-4.2.2A- 11/1/KONV-2012- 0035 LA - English DB - MTMT ER - TY - JOUR AU - Csatordai, Márta AU - Bor, Andrea AU - Gyimesi, Nóra AU - Matuz, Mária AU - Csonka, Ákos AU - Gárgyán, István AU - Doró, Péter TI - Anemia among hospitalized elderly patients JF - EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE J2 - EUR J HOSP PHARM SCI PRACT VL - 25 PY - 2018 IS - Suppl 1 SP - A165 EP - A165 SN - 2047-9956 DO - 10.1136/ejhpharm-2018-eahpconf.355 UR - https://m2.mtmt.hu/api/publication/3352161 ID - 3352161 LA - English DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Ecseri , Tamás AU - Gárgyán, István AU - Varga, Endre TI - A Tip-Apex Distance (TAD) prognosztikai jelentősége a csípőtáji törések esetén PY - 2018 UR - https://m2.mtmt.hu/api/publication/3364861 ID - 3364861 LA - Hungarian DB - MTMT ER - TY - GEN AU - Gárgyán, István AU - Vági, Zsolt AU - Csonka, Ákos AU - Furák, József AU - Tánczos, Krisztián AU - Varga, Endre TI - Bordatörések műtéti kezelése MATRIXRIB TM rendszerrel PY - 2018 UR - https://m2.mtmt.hu/api/publication/3392706 ID - 3392706 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Varga, Borisz AU - Csonka, Ákos AU - Sancha, S AU - Mulhovo, S AU - Madureira, AM AU - Ferreira, MU AU - Spengler, Gabriella TI - Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria JF - PHYTOTHERAPY RESEARCH J2 - PHYTOTHER RES VL - 32 PY - 2018 IS - 6 SP - 1039 EP - 1046 PG - 8 SN - 0951-418X DO - 10.1002/ptr.6042 UR - https://m2.mtmt.hu/api/publication/3340031 ID - 3340031 N1 - ACKNOWLEDGEMENTS This research was supported by the European Union and the State of Hungary and by the Portuguese Foundation for Science and Technology (FCT), Projects PTDC/QEQ‐MED/0905/2012 and UID/DTP/04138/2013, and co‐financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2‐11‐1‐2012‐0001 “National Excellence Program.” This study was supported by the GINOP‐2.3.2‐15‐2016‐00012 project (University of Szeged, Hungary), and Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses was supported by the ÚNKP‐17‐3 New National Excellence Program of the Ministry of Human Capacities of Hungary. The authors thank the Portuguese Embassy in Mozambique, as well as the Portuguese Office of International Affairs, for plant transport. AB - Cleistochlamys kirkii (Benth) Oliv. (Annonaceae) is a medicinal plant traditionally used in Mozambique to treat infectious diseases. The aim of this study was to find resistance modifiers in C. kirkii for Gram-positive and Gram-negative model bacterial strains. One of the most important resistance mechanisms in bacteria is the efflux pump-related multidrug resistance. Therefore, polycarpol (1), three C-benzylated flavanones (2-4), and acetylmelodorinol (5) were evaluated for their multidrug resistance-reverting activity on methicillin-susceptible and methicillin-resistant Staphylococcus aureus and Escherichia coli AG100 and AG100 A strains overexpressing and lacking the AcrAB-TolC efflux pump system. The combined effects of antibiotics and compounds (2 and 4) were also assessed by using the checkerboard microdilution method in both S. aureus strains. The relative gene expression of the efflux pump genes was determined by real-time reverse transcriptase quantitative polymerase chain reaction. The inhibition of quorum sensing was also investigated. The combined effect of the antibiotics and compound 2 or 4 on the methicillin-sensitive S. aureus resulted in synergism. The most active compounds 2 and 4 increased the expression of the efflux pump genes. These results suggested that C. kirkii constituents could be effective adjuvants in the antibiotic treatment of infections. LA - English DB - MTMT ER - TY - JOUR AU - Rauf, A AU - Shaheen, U AU - Raza, M AU - Uddin, G AU - Hadda, TB AU - Mabkhot, YN AU - Jehan, N AU - Ahmad, B AU - Raza, S AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána TI - Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus JF - PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - PAK J PHARM SCI VL - 31 PY - 2018 IS - 3 SP - 821 EP - 825 PG - 5 SN - 1011-601X UR - https://m2.mtmt.hu/api/publication/3370144 ID - 3370144 N1 - Funding Agency and Grant Number: Higher Education Commission of PakistanHigher Education Commission of Pakistan [21:619/SRGP/RD/HEC/2014]; Deanship of Scientific at King Saud University [RG-1437-29] Funding text: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29). Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, East Road of North Third RingChao Yang Dist., Beijing, China Institute of Chemical Sciences, University of Peshawar, K.P.K Peshawar, Pakistan LCM Laboratory, University of Mohamed 1st, Faculty of Sciences, Oujda, Morocco Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia Department of Geology, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Export Date: 31 July 2020 Correspondence Address: Shaheen, U.; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura UniversitySaudi Arabia; email: usamayousef2003@yahoo.com Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; chloroform, 67-66-3; Naphthoquinones; Plant Extracts Funding details: Higher Education Commision, Pakistan, HEC, 21:619/SRGP/R&D/HEC/2014 Funding text 1: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29). Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, East Road of North Third RingChao Yang Dist., Beijing, China Institute of Chemical Sciences, University of Peshawar, K.P.K Peshawar, Pakistan LCM Laboratory, University of Mohamed 1st, Faculty of Sciences, Oujda, Morocco Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia Department of Geology, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Cited By :1 Export Date: 18 January 2021 Correspondence Address: Shaheen, U.; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura UniversitySaudi Arabia; email: usamayousef2003@yahoo.com Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; chloroform, 67-66-3; Naphthoquinones; Plant Extracts Funding details: Higher Education Commision, Pakistan, HEC, 21:619/SRGP/R&D/HEC/2014 Funding text 1: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29). AB - A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks. LA - English DB - MTMT ER - TY - GEN AU - Sádt, Zoltán AU - Csonka, Ákos AU - Császár, József AU - Fetter, Gábor AU - Pintér, Sándor AU - Varga, Endre TI - Hogyan csináljuk mi?/Avagy a csípőprotézisek körül kialakult femur törések ellátása klinikánkon. PY - 2018 UR - https://m2.mtmt.hu/api/publication/3392740 ID - 3392740 LA - Hungarian DB - MTMT ER - TY - GEN AU - Varga, Endre AU - Mácsai, Attila AU - Gárgyán, István AU - Csonka, Ákos TI - TFNA szegezés — Az univerzális implantátum? PY - 2018 UR - https://m2.mtmt.hu/api/publication/3364869 ID - 3364869 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Spengler, Gabriella AU - Szilvia, Varga AU - Varga, Borisz AU - Csonka, Ákos AU - Shirley, Sancha AU - Silva, Mulhovo AU - Ana, Margarida Madureira AU - Maria-José, U Ferreira TI - CONSTITUENTS OF CLEISTOCHLAMYS KIRKII AS ANTIBACTERIALS AND EFFLUX PUMP INHIBITORS JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl.1. SP - 134 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3284046 ID - 3284046 N1 - Supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4 A/2-11-1-2012-0001'National Excellence Program' and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work was supported by the project GINOP-2.3.2-15-2016-00012. LA - English DB - MTMT ER - TY - JOUR AU - Bashir, Ahmad AU - Muhammad, Rizwan AU - Abdur, Rauf AU - Muslim, Raza AU - Shumaila, Bashir AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána AU - Mohammad, S Mubarak AU - Mah, Noor AU - Bina, S Siddiqui TI - Isolation of Chlorogenic Acid from Soil Borne Fungi Screlotium rolfsii, their Reversal of Multidrug Resistance and anti-proliferative in Mouse Lymphoma cells JF - MEDICINAL CHEMISTRY J2 - MED CHEM VL - 13 PY - 2017 IS - 8 SP - 721 EP - 726 PG - 6 SN - 1573-4064 DO - 10.2174/1573406413666170612110443 UR - https://m2.mtmt.hu/api/publication/3240653 ID - 3240653 N1 - Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, KPK-25120, Pakistan Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, 23561, Pakistan State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, No. 15 East Road of North Third Ring, Chao Yang District, Beijing, 100029, China Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza L. krt. 111, Szeged, H-6725, Hungary Department of Chemistry, University of Jordan, Amman, 11942, Jordan H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan Cited By :3 Export Date: 31 July 2020 CODEN: MCEHA Correspondence Address: Rauf, A.; Department of Chemistry, University of SwabiPakistan; email: mashaljcs@yahoo.com Chemicals/CAS: chlorogenic acid, 327-97-9; multidrug resistance protein, 149200-37-3, 208997-77-7; verapamil, 152-11-4, 52-53-9; Antineoplastic Agents, Phytogenic; Chlorogenic Acid Funding Agency and Grant Number: Higher Education Commission of PakistanHigher Education Commission of Pakistan [21:619/SRGP/RD/HEC/2014] Funding text: The authors are grateful for the financial support provided by Higher Education Commission of Pakistan for award of research start up grant No (21:619/SRGP/R&D/HEC/2014. Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, KPK-25120, Pakistan Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, 23561, Pakistan State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, No. 15 East Road of North Third Ring, Chao Yang District, Beijing, 100029, China Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza L. krt. 111, Szeged, H-6725, Hungary Department of Chemistry, University of Jordan, Amman, 11942, Jordan H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan Cited By :5 Export Date: 18 January 2021 CODEN: MCEHA Correspondence Address: Rauf, A.; Department of Chemistry, University of SwabiPakistan; email: mashaljcs@yahoo.com Chemicals/CAS: chlorogenic acid, 327-97-9; multidrug resistance protein, 149200-37-3, 208997-77-7; verapamil, 152-11-4, 52-53-9; Antineoplastic Agents, Phytogenic; Chlorogenic Acid AB - BACKGROUND: Fungi performing a wide range of function in soil by secreting low molecular weight compound known as secondary metabolites. S. rolfsii is a soil borne phytopathogenic fungi was used for the production of bioactive compounds. OBJECTIVE: The present study belongs to evaluate the anticancer potentials of a secondary metabolites isolated from S. rolfsii, their multidrug resistance (MDR), and molecular docking study. METHOD: (1S,3R,4R,5R,E)-3-(3-(3,4-Dihydroxyphenyl)acryloyloxy)-1,4,5 trihydroxycyclohexanecarboxylic acid (1), or best known as chlorogenic acid, was isolated from the ethyl acetate fraction of crude secondary metabolites produced by the soil borne Fungus Screlotium rolfsii. Structure of chlorogenic acid (1) was confirmed by means of FT-IR, 1H NMR, 13C NMR, and mass spectrometry as well as by melting point. RESULTS: Effect of compound 1 on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) against cancer cells was evaluated with a rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma. Compound 1 was also evaluated for Anti-proliferative effect on the L5178 mouse T-cell lymphoma cell line. CONCLUSION: Results from the present investigation revealed that compound 1 exhibits excellent MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Compound 1 also showed anti-proliferative effect on L5178Y mouse T-lymphoma cell line. LA - English DB - MTMT ER - TY - JOUR AU - Berta, Barta Holló AU - József, Magyari AU - Kincses, Annamária AU - Gajdács, Márió AU - Nové, Márta AU - Varga, Borisz AU - Csonka, Ákos AU - Spengler, Gabriella AU - Katalin, Mészáros Szécsényi TI - Antibacterial Activity of Hydrazone-Based Transition Metal Complexes JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl. 1 SP - 112 EP - 112 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3283951 ID - 3283951 N1 - This study was supported by the project GINOP-2.3.2-15-2016-00038. This study was also supported by the János Bolyai Scholarship of the Hungarian Academy of Sciences. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Borisz AU - Csonka, Ákos AU - Csonka, Andrea AU - Molnár, József AU - Leonard, Amaral AU - Spengler, Gabriella TI - Possible Biological and Clinical Applications of Phenothiazines JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 37 PY - 2017 IS - 11 SP - 5983 EP - 5993 PG - 11 SN - 0250-7005 DO - 10.21873/anticanres.12045 UR - https://m2.mtmt.hu/api/publication/3271829 ID - 3271829 N1 - This research was supported by the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, cofinanced by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Travel Medicine, Institute of Hygiene and Tropical Medicine, New University of Lisbon, Lisbon, Portugal Cited By :51 Export Date: 3 June 2021 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Dóm tér 10, Hungary; email: spengler.gabriella@med.uszeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Csatordai, Márta AU - Bor, Andrea AU - Szalai, Gábor AU - Csonka, Ákos AU - Gárgyán, István AU - Doró, Péter TI - Polypharmacy among hospitalized, elderly patients JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 87 PY - 2017 IS - 3-4 SP - 227 EP - 227 PG - 1 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/3317060 ID - 3317060 LA - English DB - MTMT ER - TY - JOUR AU - Csatordai, Márta AU - Bor, Andrea AU - Gyimesi, Nóra AU - Csonka, Ákos AU - Doró, Géza AU - Gárgyán, István AU - Doró, Péter TI - Potenciálisan nem megfelelő gyógyszerek alkalmazása idős, kórházi betegek körében JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 61 PY - 2017 IS - Suppl SP - S15 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/3221190 ID - 3221190 LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Gárgyán, István AU - Doró, Péter AU - Sádt, Zoltán AU - Vági, Zsolt AU - Varga, Endre TI - Atípusos femurtörések ellátása PY - 2017 UR - https://m2.mtmt.hu/api/publication/3321558 ID - 3321558 LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Gárgyán, István AU - Doró, Péter AU - Sádt, Zoltán AU - Vági, Zsolt AU - Varga, Endre TI - A típusos femurtörések kezelése PY - 2017 SP - 26 UR - https://m2.mtmt.hu/api/publication/3240916 ID - 3240916 LA - Hungarian DB - MTMT ER - TY - GEN AU - Faludi, László AU - Csonka, Ákos AU - Varga, Endre AU - Gárgyán, István TI - A hemiarthroplasticaval kezelt combnyaktörések eredményei klinikánkon PY - 2017 SP - 19 UR - https://m2.mtmt.hu/api/publication/3240883 ID - 3240883 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gárgyán, István AU - Vági, Zsolt AU - Csonka, Ákos AU - Furák, József AU - Tánczos, Krisztián AU - Varga, Endre TI - Bordatörések műtéti kezelése MatrixRIB(TM) rendszerrel JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 60 PY - 2017 IS - 3-4 SP - 79 EP - 87 PG - 9 SN - 1217-3231 DO - 10.21755/MTO.2017.060.0304.001 UR - https://m2.mtmt.hu/api/publication/3381158 ID - 3381158 LA - Hungarian DB - MTMT ER - TY - GEN AU - Gárgyán, István AU - Vági, Zsolt AU - Csonka, Ákos AU - Varga, Endre TI - Az időskori osteoporotikus medencetörések diagnosztikája PY - 2017 UR - https://m2.mtmt.hu/api/publication/3278167 ID - 3278167 N1 - [előadás] LA - Hungarian DB - MTMT ER - TY - GEN AU - Gárgyán, István AU - Vági, Zsolt AU - Csonka, Ákos AU - Varga, Endre TI - Időskori osteoporoticus medencetörések diagnosztikája PY - 2017 SP - 18 UR - https://m2.mtmt.hu/api/publication/3240873 ID - 3240873 LA - Hungarian DB - MTMT ER - TY - CONF AU - Csatordai, Márta AU - Benkő, Ria AU - Bor, Andrea AU - Csonka, Ákos AU - Géza, Doró AU - Gárgyán, István AU - Doró, Péter TI - Potentially inappropriate medication use among elderly, hospitalized patients T2 - European Drug Utilisation Research Group (EuroDURG) Conference 2017: Program and Abstracts PY - 2017 SP - 102 EP - 102 PG - 1 UR - https://m2.mtmt.hu/api/publication/3317455 ID - 3317455 LA - English DB - MTMT ER - TY - JOUR AU - Ahmad, B AU - Rizwan, M AU - Rauf, A AU - Raza, M AU - Azam, S AU - Bashir, S AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána TI - Isolation and Structure Elucidation, Molecular Docking Studies of Screlotiumol from Soil Borne Fungi Screlotium rolfsii and their Reversal of Multidrug Resistance in Mouse Lymphoma Cells JF - ASIAN PACIFIC JOURNAL OF CANCER PREVENTION J2 - ASIAN PAC J CANCER P VL - 17 PY - 2016 IS - 4 SP - 2083 EP - 2087 PG - 5 SN - 1513-7368 DO - 10.7314/APJCP.2016.17.4.2083 UR - https://m2.mtmt.hu/api/publication/3073568 ID - 3073568 N1 - Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, Pakistan Department of Geology, University of Swabi, Ambar, Khyber Pakhtunkhwa, Pakistan State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China Department of Pharmacy, University of Peshawar, Peshawar, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Cited By :4 Export Date: 31 July 2020 Correspondence Address: Rauf, A.; Department of Geology, University of SwabiPakistan; email: mashaljcs@yahoo.com Chemicals/CAS: acetic acid ethyl ester, 141-78-6; multidrug resistance protein, 149200-37-3, 208997-77-7; ABCB1 protein, human; Acetates; Antineoplastic Agents; Benzopyrans; ethyl acetate; P-Glycoproteins; Plant Extracts; screlotiumol Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, Pakistan Department of Geology, University of Swabi, Ambar, Khyber Pakhtunkhwa, Pakistan State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China Department of Pharmacy, University of Peshawar, Peshawar, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Cited By :4 Export Date: 18 January 2021 Correspondence Address: Rauf, A.; Department of Geology, University of SwabiPakistan; email: mashaljcs@yahoo.com Chemicals/CAS: acetic acid ethyl ester, 141-78-6; multidrug resistance protein, 149200-37-3, 208997-77-7; ABCB1 protein, human; Acetates; Antineoplastic Agents; Benzopyrans; ethyl acetate; P-Glycoproteins; Plant Extracts; screlotiumol AB - A new compound namely (13-(3,3-dihydroxypropyl)-1,6-dihydroxy-3,4-dihydro-1H-isochromen-8(5H)-one (1) was isolated from an ethyl acetate extract of the borne fungi Screlotium rolfsii. Its chemical structure was elucidated by spectroscopic analysis. Screlotiumol 1 were evaluated for their effects on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) of the soil borne fungi. The multidrug resistant P-glycoprotein is a target for chemotherapeutic drugs in cancer cells. In the present study rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma which showed excellent MDR reversing effect in a dose dependent manner against mouse T-lymphoma cell line. Moreover, molecular docking studies of compound-1 also showed better results as compared with the standard. Therefore the preliminary results obtained from this study suggest that screlotiumol 1 could be used as a potential agent for the treatment of cancer. LA - English DB - MTMT ER - TY - JOUR AU - Bor, Andrea AU - Soós, Gyöngyvér AU - Csatordai, Márta AU - Gyimesi, Nóra AU - Csonka, Ákos AU - Doró, G AU - Gárgyán, István AU - Doró, Péter TI - Risks of surgical intervention in patients taking oral anticoagulants JF - EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE J2 - EUR J HOSP PHARM SCI PRACT VL - 23 PY - 2016 IS - Suppl 1 SP - 51 EP - 52 PG - 2 SN - 2047-9956 DO - 10.1136/ejhpharm-2016-000875.117 UR - https://m2.mtmt.hu/api/publication/3045538 ID - 3045538 LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Ákos TI - Rezisztenciamódosítók összehasonlítása multidrog-rezisztens prosztata-, egérlymphoma- és vastagbélrák-sejtvonalakon [Comparison of the effect of multidrug resistance modifiers on prostate cancer, mouse lymphoma and colon cancer cells] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 157 PY - 2016 IS - 37 SP - 1489 EP - 1495 PG - 7 SN - 0030-6002 DO - 10.1556/650.2016.30536 UR - https://m2.mtmt.hu/api/publication/3110735 ID - 3110735 AB - INTRODUCTION: The reason for unsuccessful tumor chemotherapy is related to multidrug resistance. An important factor is the overexpression of efflux pumps, such as P-glycoprotein. AIM: Amino- and amide-substituted steroid compounds and phenothiazine derivatives were investigated in tumor models in vitro. METHOD: The inhibition of P-glycoprotein was evaluated by flow cytometry and the interaction of these compounds with doxorubicin was investigated as well. Molecular docking was used to estimate the binding energies of the compounds to P-glycoprotein. RESULTS: The aminosteroids showed anticancer activity on multidrug resistant mouse T-lymphoma and prostate cancer cell lines. The combination of steroids and doxorubicin potentiated its effect in hormone resistant prostate cancer cells. Among the N-hydroxyalkyl-2-aminophenothiazines, secondary amines exhibited anticancer effects on multidrug resistant colon adenocarcinoma cells. CONCLUSIONS: The tested phenothiazine and steroid derivatives showed potent anticancer activity, furthermore, the stereoisomerism of thioridazine did not play a role in the antitumor properties. Neither steroids nor thioridazine influenced apoptosis in hormone resistant cells. Orv. Hetil., 2016, 157(37), 1489-1495. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Sikarinkul, E AU - Gárgyán, István AU - Boa, Kristóf AU - Varga, Endre TI - Operative management of bilateral Salter-Harris type III fractures of the proximal phalanges of the great toes of a 10-year-old female ballet dancer. a case report TS - a case report JF - JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B J2 - J PEDIATR ORTHOP B VL - 25 PY - 2016 IS - 4 SP - 393 EP - 396 PG - 4 SN - 1060-152X DO - 10.1097/BPB.0000000000000284 UR - https://m2.mtmt.hu/api/publication/3026838 ID - 3026838 AB - Differentiation between the normal variant cleft epiphysis and Salter-Harris type III fracture of the first proximal phalanges of the foot in children might be challenging. The authors describe a case of a 10-year-old ballet dancer girl with bilateral epiphyseal segmentation of the first proximal phalanges of the foot, unresponsive to conservative treatment. Considered a nonhealing stress-induced fracture, operative treatment with closed reduction and Herbert screw insertion was chosen on both sides. Complete union was achieved, with significant reduction of pain. The presented case suggests that internal fixation can be a viable option in the treatment of the problem. LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Gárgyán, István AU - Böröndy, János AU - Boa, Kristóf AU - Varga, Endre TI - Megoldást jelent-e a szögstabil implantátumok bevezetése a proximalis humerus törések ellátásában? JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 59 PY - 2016 IS - 3-4 SP - 107 EP - 112 PG - 6 SN - 1217-3231 DO - 10.21755/MTO.2016.059.0304.003 UR - https://m2.mtmt.hu/api/publication/3293179 ID - 3293179 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Gárgyán, István AU - Boa, Kristóf AU - Sádt, Zoltán AU - Varga, Endre TI - Bicondylaris tibia plató törések kettős lemezelése JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 59 PY - 2016 IS - 3-4 SP - 99 EP - 105 PG - 7 SN - 1217-3231 DO - 10.21755/MTO.2016.059.0304.002 UR - https://m2.mtmt.hu/api/publication/3293175 ID - 3293175 LA - Hungarian DB - MTMT ER - TY - THES AU - Csonka, Ákos TI - Comparison of the effects of resistance modifiers on prostate cancer, mouse lymphoma and colon cancer cells PB - Szegedi Tudományegyetem (SZTE) PY - 2016 SP - 56 DO - 10.14232/phd.2835 UR - https://m2.mtmt.hu/api/publication/3008920 ID - 3008920 LA - English DB - MTMT ER - TY - JOUR AU - Das, U AU - Pati, HN AU - Baráth, Zoltán Lajos AU - Csonka, Ákos AU - Molnár, József AU - Dimmock, JR TI - 1-[3-(2-Hydroxyethylsulfanyl)propanoyl]-3,5-bis(benzylidene)-4-piperidones: A novel cluster of P-glycoprotein dependent multidrug resistance modulators JF - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS J2 - BIOORG MED CHEM LETT VL - 26 PY - 2016 IS - 4 SP - 1319 EP - 1321 PG - 3 SN - 0960-894X DO - 10.1016/j.bmcl.2016.01.005 UR - https://m2.mtmt.hu/api/publication/3006445 ID - 3006445 N1 - Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada Institute of Medical Microbiology and Immunology, University of Szeged, Szeged, H-6720, Hungary Cited By :5 Export Date: 17 April 2022 CODEN: BMCLE Correspondence Address: Das, U.; Drug Discovery and Development Research Group, 110 Science Place, Canada; email: umashankar.das@usask.ca Chemicals/CAS: melphalan, 148-82-3; multidrug resistance protein, 149200-37-3, 208997-77-7; verapamil, 152-11-4, 52-53-9; 3,5-bis(benzylidene)-4-piperidone; P-Glycoprotein; Piperidones Funding details: Canadian Institutes of Health Research, CIHR Funding text 1: The authors thank the Canadian Institutes of Health Research , Canada and the Foundation for Cancer Research Szeged , Hungary for financial support. AB - A series of 1-[3-(2-hydroxyethylsulfanyl)propanoyl]-3,5-bis(benzylidene)-4-piperidones 4a-e display promising P-glycoprotein dependent multidrug resistance (MDR) revertant properties and are significantly more potent than a reference drug verapamil when evaluated against L-5178Y MDR lymphoma cells. These dienones may be referred to as dual agents having both MDR revertant properties and tumour-selective cytotoxicity. In particular, 3,5-bis(4-chlorobenzylidene)-1-[3-(2-hydroxyethylsulfanyl]propanoyl-4-piperidone 4d emerged as a lead molecule for further development based on its MDR revertant properties, cytotoxic potencies and tumour-selective toxicity. The structure-activity relationships reveal important structural requirements for further designing of potent MDR revertants. LA - English DB - MTMT ER - TY - GEN AU - Faludi, László AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre TI - A hemiarthroplasticaval kezelt combnyaktörések eredményei klinikánkon PY - 2016 UR - https://m2.mtmt.hu/api/publication/3115859 ID - 3115859 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - JOUR AU - Faludi, László AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre TI - A hemiarthroplasticaval kezelt combnyaktörések eredményei klinikánkon JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 59 PY - 2016 IS - Suppl. SP - 109 EP - 109 PG - 1 SN - 1217-3231 UR - https://m2.mtmt.hu/api/publication/3108350 ID - 3108350 LA - Hungarian DB - MTMT ER - TY - GEN AU - Gárgyán, István AU - Csonka, Ákos AU - Varga, Endre TI - Tömeges migráció Magyarországon - Klinikánk tapasztalatai PY - 2016 UR - https://m2.mtmt.hu/api/publication/3115861 ID - 3115861 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gárgyán, István AU - Csonka, Ákos AU - Varga, Endre TI - Tömeges migráció Magyarországon - Klinikánk tapasztalatai JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 59 PY - 2016 IS - Suppl. SP - 146 PG - 1 SN - 1217-3231 UR - https://m2.mtmt.hu/api/publication/3108339 ID - 3108339 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Rauf, A AU - Uddin, G AU - Raza, M AU - Ahmad, A AU - Jehan, N AU - Ahmad, B AU - Nisar, M AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána AU - Khan, A AU - Farooq, U AU - Noor, M TI - Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima. JF - ASIAN PACIFIC JOURNAL OF CANCER PREVENTION J2 - ASIAN PAC J CANCER P VL - 17 PY - 2016 IS - 4 SP - 2311 EP - 2314 PG - 4 SN - 1513-7368 DO - 10.7314/APJCP.2016.17.4.2311 UR - https://m2.mtmt.hu/api/publication/3073567 ID - 3073567 AB - Pistagremic acid (PA) is a bioactive triterpenoid isolated from various parts of Pistacia integerrima plants. The aim of this research was to investigate PA for reversion of multidrug resistant (MDR) mediated by P-glycoprotein using rhodamine-123 exclusion study on a multidrug resistant human ABCB1 (ATP-binding cassette, sub-family B, member 1) gene-transfected mouse T-lymphoma cell line in vitro. Results were similar to those with verapamil as a positive control. Docking studies of PA and standard Rhodamine123 were carried out against a P-gp crystal structure which showed satisfactory results. Actually, PA cannot bind exactly where co-crystallized ligand of P-gp is already present. However, the docking study predicted that if a compound gives a lesser score then it may have some potency. The docking scores of PA and Rhodamine were similar. Therefore, we can conclude that there are certain important chemical features of PA which are responsible for the inhibiting potency of P-gp. LA - English DB - MTMT ER - TY - JOUR AU - Rauf, A AU - Uddin, G AU - Raza, M AU - Ahmad, B AU - Jehan, N AU - Siddiqui, BS AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána TI - Reversal of Multidrug Resistance in Mouse Lymphoma Cells by Extracts and Flavonoids from Pistacia integerrima JF - ASIAN PACIFIC JOURNAL OF CANCER PREVENTION J2 - ASIAN PAC J CANCER P VL - 17 PY - 2016 IS - 1 SP - 51 EP - 55 PG - 5 SN - 1513-7368 DO - 10.7314/APJCP.2016.17.1.51 UR - https://m2.mtmt.hu/api/publication/3013412 ID - 3013412 AB - Phytochemical investigation of Pistacia integerrima has highlighted isolation of two known compounds naringenin (1) and dihydrokaempferol (2). A crude extract and these isolated compounds were here evaluated for their effects on reversion of multidrug resistance (MDR) mediated by P-glycoprotein (P-gp). The multidrug resistance P-glycoprotein is a target for chemotherapeutic drugs from cancer cells. In the present study rhodamine- 123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma cells showed excellent MDR reversing effects in a dose dependent manner. In-silico molecular docking investigations demonstrated a common binding site for Rhodamine123, and compounds naringenin and dihydrokaempferol. Our results showed that the relative docking energies estimated by docking softwares were in satisfactory correlation with the experimental activities. Preliminary interaction profile of P-gp docked complexes were also analysed in order to understand the nature of binding modes of these compounds. Our computational investigation suggested that the compounds interactions with the hydrophobic pocket of P-gp are mainly related to the inhibitory activity. Moreover this study s a platform for the discovery of novel natural compounds from herbal origin, as inhibitor molecules against the P-glycoprotein for the treatment of cancer. LA - English DB - MTMT ER - TY - GEN AU - Sádt, Zoltán AU - Körmöndi, Sándor Pál AU - Horváth, Attila AU - Süveges, Gábor AU - Csonka, Ákos AU - Varga, Endre TI - A csípőtáji törések intramedullaris szegezésének problémái PY - 2016 UR - https://m2.mtmt.hu/api/publication/3115863 ID - 3115863 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - JOUR AU - Sádt, Zoltán AU - Körmöndi, Sándor Pál AU - Horváth, Attila AU - Süveges, Gábor AU - Csonka, Ákos AU - Varga, Endre TI - A csípőtáji törések intramedullaris szegezésének problémái JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 59 PY - 2016 IS - Suppl. SP - 105 EP - 106 PG - 2 SN - 1217-3231 UR - https://m2.mtmt.hu/api/publication/3108353 ID - 3108353 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Csonka, Ákos AU - Molnár, József AU - Amaral, L TI - The Anticancer Activity of the Old Neuroleptic Phenothiazine-type Drug Thioridazine JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 36 PY - 2016 IS - 11 SP - 5701 EP - 5706 PG - 6 SN - 0250-7005 DO - 10.21873/anticanres.11153 UR - https://m2.mtmt.hu/api/publication/3135012 ID - 3135012 N1 - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Travel Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal Cited By :11 Export Date: 31 July 2020 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Hungary; email: spengler.gabriella@med.u-szeged.hu Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; thioridazine, 130-61-0, 50-52-2; verapamil, 152-11-4, 52-53-9; phenothiazine, 92-84-2; Antineoplastic Agents; Antipsychotic Agents; phenothiazine; Phenothiazines; Thioridazine AB - Thioridazine (TZ), an antipsychotic drug, renders multidrug-resistant (MDR) cancer cells susceptible to cytotoxic agents to which they were initially resistant, has anti-prolilferative activity and apoptosis-inducing properties in various tumor cell lines and cancer stem cells. Whereas the anti-proliferative activity takes place at high concentrations that ensure the intercalation of the compound between nucleic bases (especially rich in G/C bases), much lower concentrations inhibit the export function of the ABCB1 (P-glycoprotein), which is responsible for the MDR phenotype of the cancer cell. The co-administration of TZ with doxorubicin inhibits efflux of doxorubicin and, hence, increases the intracellular concentration of anticancer drug. The (+) and (-) enantiomers of TZ have the same activities as TZ. The main focus of this review is to present extensive evidence provided by our work, confirmed by much later studies, as it supports adjuvant use of TZ with an anticancer drug for MDR cancer therapy. LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Hamdoun, S AU - Spengler, Gabriella AU - Martins, Ana AU - Vincze, I AU - Efferth, T AU - Molnár, József TI - Substituted steroidal compounds containing amino and amido groups reverse multidrug resistance of mouse T-lymphoma and two human prostate cancer cell lines in vitro JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 35 PY - 2015 IS - 4 SP - 2105 EP - 2112 PG - 8 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2879234 ID - 2879234 N1 - Megjegyzés-24755981 N1 Funding Details: SFRH/BPD/81118/2011, FCT, Fundação para a Ciência e a Tecnologia AB - BACKGROUND: Resistance to chemotherapy is a main problem in cancer. The search for new effective compounds that can increase sensitivity of resistant cells to existing chemotherapeutics is an urgent need. In previous studies, it has been demonstrated that steroid derivatives showed promising results concerning their capacity to modulate resistance of multidrug-resistant cell lines. MATERIALS AND METHODS: Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multidrug resistance, apoptosis induction, and interaction with doxorubicin on multidrug resistant human ATP-binding cassette, sub-family B, member 1 (ABCB1) gene-transfected mouse T-lymphoma cell line, and human PC-3 and LNCaP prostate cancer cell lines in vitro. The steroidal interaction with P-glycoprotein (ABCB1) was investigated by molecular docking. RESULTS: Both the activity of steroid derivatives on inhibition of the ABCB1 pump and their interaction with doxorubicin are dependent on the substituent groups of the investigated steroidal structures. Even though the investigated steroid derivatives were found to have limited antiproliferative effect on the three different cancer cell lines, in combination with doxorubicin, most of them acted as good potentiators. The binding energies from molecular docking ranged from -6.43 to -9.88 kcal/mol. The predicted inhibition constants ranged from 0.1 to 10.1 muM. A significant negative correlation was found between binding energy and fluorescence activity ratio (R=-0.5, p=0.015). CONCLUSION: The effective compounds can be candidates of model molecules for possible application in the treatment of multidrug resistant cancer in rational drug design. LA - English DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre TI - TFNA - ÚJ LEHETŐSÉG A PERTROCHANTER TÖRÉSEK ELLÁTÁSÁBAN PY - 2015 UR - https://m2.mtmt.hu/api/publication/2910024 ID - 2910024 N1 - [előadás] LA - Hungarian DB - MTMT ER - TY - CONF AU - Doró, Péter AU - Bor, Andrea AU - Gyimesi, Nóra AU - Csatordai, Márta AU - Csonka, Ákos AU - Doró, Géza AU - Gárgyán, István TI - Orális antikoaguláns kezelésben részesülők műtéti kockázatai T2 - Kórházi Gyógyszerészek XX. Kongresszusa PY - 2015 SP - 50 EP - 50 PG - 1 UR - https://m2.mtmt.hu/api/publication/2889650 ID - 2889650 N1 - [előadás] LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gárgyán, István AU - Csonka, Ákos AU - Boa, Kristóf AU - Körmöndi, Sándor Pál AU - Tóth, Kálmán AU - Varga, Endre TI - Periprotetikus distalis femurtörések minimál invazív lemezes rögzítése totál térdprotézis beültetése után JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 58 PY - 2015 IS - 4 SP - 209 EP - 216 PG - 8 SN - 1217-3231 DO - 10.21755/MTO.2015.058.0004.002 UR - https://m2.mtmt.hu/api/publication/3060497 ID - 3060497 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gárgyán, István AU - Vági, Zsolt AU - Csonka, Ákos AU - Boa, Kristóf AU - Varga, Endre TI - ß-tricalcium phosphate granulátum alkalmazása a tibia plató törések kezelésében JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 58 PY - 2015 IS - 4 SP - 201 EP - 207 PG - 7 SN - 1217-3231 DO - 10.21755/MTO.2015.058.0004.001 UR - https://m2.mtmt.hu/api/publication/3060492 ID - 3060492 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gárgyán, István AU - Csonka, Ákos AU - Kószó, Balázs AU - Vági, Zsolt AU - Berényi, Zsolt AU - Varga, Endre TI - Időskori szeméremcsonttörések, okkult hátsó gyűrű sérülések vizsgálata JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 58 PY - 2015 IS - 1 SP - 19 EP - 25 PG - 7 SN - 1217-3231 DO - 10.21755/MTO.2015.058.0001.002 UR - https://m2.mtmt.hu/api/publication/2927598 ID - 2927598 N1 - A Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ Traumatológiai Klinika,és a Diagnoscan Magyarország Kft. közleménye. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gárgyán, István AU - Csonka, Ákos AU - Boa, Kristóf AU - Varga, Endre TI - COMPLEX TREATMENT OF COMPLICATED CRURAL DECOLLEMENT INJURY IN A DIABETIC PATIENT JF - EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY J2 - EUR J TRAUMA EMERG S VL - 41 PY - 2015 IS - Suppl. 2 SP - S182 SN - 1863-9933 UR - https://m2.mtmt.hu/api/publication/2892375 ID - 2892375 N1 - [poszter] P195 LA - English DB - MTMT ER - TY - JOUR AU - Gárgyán, István AU - Csonka, Ákos AU - Kószó, Balázs AU - Varga, Endre TI - ASSESSMENT OF OCCULT POSTERIOR PELVIC RING INJURIES IN ELDERLY PATIENTS JF - EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY J2 - EUR J TRAUMA EMERG S VL - 41 PY - 2015 IS - Suppl. 2 SP - S99 SN - 1863-9933 UR - https://m2.mtmt.hu/api/publication/2892343 ID - 2892343 LA - English DB - MTMT ER - TY - JOUR AU - Boa, Kristóf AU - Endre, Varga Jr AU - Gabor, Pinter AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre TI - External cooling efficiently controls intraosseous temperature rise caused by drilling in a drilling guide system: an in vitro study JF - BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY J2 - BRIT J ORAL MAX SURG VL - 53 PY - 2015 IS - 10 SP - 963 EP - 967 PG - 5 SN - 0266-4356 DO - 10.1016/j.bjoms.2015.07.013 UR - https://m2.mtmt.hu/api/publication/2931622 ID - 2931622 LA - English DB - MTMT ER - TY - JOUR AU - Rauf, A AU - Uddin, G AU - Siddiqui, BS AU - Molnár, József AU - Csonka, Ákos AU - Ahmad, B AU - Szabó, Diána AU - Farooq, U AU - Khan, A TI - A Rare Class of New Dimeric Naphthoquinones from Diospyros lotus have Multidrug Reversal and Antiproliferative Effects JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 16 PY - 2015 IS - 6 PG - 9 SN - 1663-9812 DO - 10.3389/fphar.2015.00293 UR - https://m2.mtmt.hu/api/publication/2973115 ID - 2973115 LA - English DB - MTMT ER - TY - GEN AU - Spengler, Gabriella AU - Mosolygó, Tímea AU - Molnár, József AU - Csonka, Andrea AU - Csonka, Ákos AU - Amaral, Leonard AU - Burián, Katalin TI - The anti-chlamydial effect of phenothiazines and disiloxane derivatives PY - 2015 UR - https://m2.mtmt.hu/api/publication/2901849 ID - 2901849 N1 - [Abstract (eposter)] LA - English DB - MTMT ER - TY - JOUR AU - Takács, Daniella AU - Csonka, Ákos AU - Horváth, Ádám AU - Windt, Tímea AU - Gajdács, Márió AU - Riedl, Zsuzsanna AU - Hajós, György AU - Amaral, L AU - Molnár, József AU - Spengler, Gabriella TI - Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines. JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 35 PY - 2015 IS - 6 SP - 3245 EP - 3251 PG - 7 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2901785 ID - 2901785 AB - BACKGROUND: The most common mechanism that reduces the efficacy of anticancer agents is overexpression of ATP-binding cassette (ABC) drug transporters. Phenothiazines and structurally-related compounds can sensitize multidrug-resistant (MDR) cells to chemotherapeutics. MATERIALS AND METHODS: Phenothiazine derivatives were investigated regarding their anticancer and MDR-reversing effect on colonic adenocarcinoma cells. The anti-proliferative and cytotoxic effects of the derivatives were assessed by the thiazolyl blue tetrazolium bromide (MTT) method, the modulation of the ABCB1 activity was measured by rhodamine 123 accumulation assay using flow cytometry. RESULTS: All phenothiazines exhibited potent cytotoxic effect on the sensitive and MDR colon adenocarcinoma cell lines. The inhibition of the ABCB1 transporter was greater in the presence of the phenothiazine derivatives than for the known ABCB1 inhibitor verapamil. CONCLUSION: It can be concluded that these derivatives show synergism in the presence of doxorubicin and could have potential as ABCB1 inhibitors. LA - English DB - MTMT ER - TY - JOUR AU - Mosolygó, Tímea AU - MARION, SZATMÁRI AU - Molnár, József AU - Csonka, Andrea AU - Csonka, Ákos AU - LEONARD, AMARAL AU - Burián, Katalin AU - Spengler, Gabriella TI - NEW PERSPECTIVES IN THE TREATMENT OF CHLAMYDIA TRACHOMATIS INFECTIONS: PHENOTHIAZINES AND DISILOXANE DERIVATIVES AS POTENTIAL ANTI-CHLAMYDIAL AGENTS JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 62 PY - 2015 IS - Suppl. 1. SP - 182 EP - 183 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3063503 ID - 3063503 N1 - kötet DOI: http://dx.doi.org/10.1556/030.62.2015.Suppl.2 LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Spengler, Gabriella AU - Martins, Ana AU - Irén, Vincze AU - Molnár, József TI - COMPARISON OF CYTOTOXICITY OF BUTYL-OXI-CARBONYL SUBSTITUTED STEROIDAL COMPOUNDS ON DIFFERENT CANCER CELL LINES IN VITRO JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 34 PY - 2014 IS - 10 SP - 5870 EP - 5871 PG - 2 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2757032 ID - 2757032 N1 - Meeting Abstract: 128 LA - English DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Gabriella, Splenger AU - Ana, Martins AU - Irén, Vincze AU - Joseph, Molnar TI - Comparison of Cytotoxicity of Butyl-Oxi-Carbonyl substituted steroidal compounds on different cancer cell lines in vitro PY - 2014 UR - https://m2.mtmt.hu/api/publication/2756110 ID - 2756110 LA - English DB - MTMT ER - TY - GEN AU - Bor, Andrea AU - Gyimesi, Nóra AU - Matuz, Mária AU - Doró, Géza AU - Csonka, Ákos AU - Gárgyán, István AU - Doró, Péter TI - Tomportáji törést szenvedett betegek gyógyszerelésének jellemzői, és azok kórházi kimenetellel való összefüggéseinek vizsgálata PY - 2014 UR - https://m2.mtmt.hu/api/publication/2708436 ID - 2708436 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csonka, Ákos TI - Szteroid vegyületek hatása tumor sejtvonalakon JF - LÉTÜNK (ÚJVIDÉK) J2 - LÉTÜNK (ÚJVIDÉK) VL - 4 PY - 2014 SP - 66 EP - 72 PG - 7 SN - 0350-4158 UR - https://m2.mtmt.hu/api/publication/2893802 ID - 2893802 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Gárgyán, István AU - Doró, Péter AU - Varga, Endre TI - Atípusos femurtörés JF - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET J2 - MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET VL - 57 PY - 2014 IS - 2-3 SP - 119 EP - 124 PG - 6 SN - 1217-3231 DO - 10.21755/MTO.2014.057.0203.005 UR - https://m2.mtmt.hu/api/publication/2785874 ID - 2785874 LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Simonka, János Aurél AU - Varga, Endre AU - Mácsai, Attila TI - Elnézett perilunaris ficam késői ellátása és tanulságai. PY - 2014 UR - https://m2.mtmt.hu/api/publication/2732657 ID - 2732657 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Varga, Endre AU - Török, László AU - Mácsai, Attila AU - Ábrahám, Szabolcs AU - Deák, Gábor TI - Hogy kerül az ileum a kenelbe? PY - 2014 UR - https://m2.mtmt.hu/api/publication/2706664 ID - 2706664 N1 - [Poszter] LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre AU - Kószó, Balázs AU - Vági, Zsolt TI - Csontpótló anyagok használata tibia plateau töréseknél PY - 2014 UR - https://m2.mtmt.hu/api/publication/2706656 ID - 2706656 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre AU - Kószó, Balázs AU - Vági, Zsolt AU - Sádt, Zoltán TI - Időskori szeméremcsont törések okkult medencegyűrű sérülésének vizsgálata PY - 2014 UR - https://m2.mtmt.hu/api/publication/2706655 ID - 2706655 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Gárgyán, István AU - Varga, Endre AU - Sádt, Zoltán AU - Vági, Zsolt AU - Doró, Péter TI - Atípusos femurtörések kezelése PY - 2014 UR - https://m2.mtmt.hu/api/publication/2706652 ID - 2706652 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Faludi, László AU - Sádt, Zoltán AU - Gárgyán, István AU - Varga, Endre TI - Klinikánk geriátriai programjának értékelése, a protetizált combnyaktörött betegek kapcsán PY - 2014 UR - https://m2.mtmt.hu/api/publication/2706648 ID - 2706648 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - GEN AU - Csonka, Ákos AU - Bánki, László AU - Csonka, Endre AU - Varga, Endre AU - Gárgyán, István AU - Polyák, Ilona TI - Beszámoló a klinikánkon bevezetett osteoporosis protokollról, ill. az eddig elért eredményekről PY - 2014 UR - https://m2.mtmt.hu/api/publication/2706636 ID - 2706636 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - CONF AU - Csonka, Ákos AU - Spengler, Gabriella AU - Martins, Ana AU - Ocsovszki, Imre AU - Chritsten, Jorn B AU - Hendricks, Oliver AU - Kristiansen, Jette E AU - Amaral, Leonard AU - Molnár, József TI - Anticancer activity of thioridazine stereoisomers T2 - ICACT 2014 PY - 2014 UR - https://m2.mtmt.hu/api/publication/2526922 ID - 2526922 LA - English DB - MTMT ER - TY - GEN AU - Gárgyán, István AU - Körmöndi, Sándor Pál AU - Csonka, Ákos AU - Vági, Zsolt AU - Varga, Endre TI - Distalis femurtörések rögzítése LISS-DF lemezzel totál térdprotézis beültetése után PY - 2014 UR - https://m2.mtmt.hu/api/publication/2591453 ID - 2591453 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - GEN AU - Simonka, János Aurél AU - Varga, Endre AU - Csonka, Ákos AU - Polyák, Ilona AU - Butt, Edina TI - Scaphoideum álízület kezelésének lehetőségei (irodalmi kitekintés, műtéti technika és 41 eset elemzése) PY - 2014 UR - https://m2.mtmt.hu/api/publication/2732650 ID - 2732650 N1 - [Előadás] LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Spengler, Gabriella AU - Martins, Ana AU - Ocsovszki, Imre AU - Christensen, JB AU - Hendricks, O AU - Kristiansen, JE AU - Amaral, L AU - Molnár, József TI - Effect of thioridazine stereoisomers on the drug accumulation of mouse lymphoma and human prostate cancer cell lines in vitro. JF - IN VIVO J2 - IN VIVO VL - 27 PY - 2013 IS - 6 SP - 815 EP - 820 PG - 6 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/2470103 ID - 2470103 AB - BACKGROUND: Cancer cells become refractory to chemotherapy as a consequence of their overexpression of multidrug transporters. MATERIALS AND METHODS: The anticancer and multidrug resistance (MDR) reversal effects of the racemic form and the two enantiomers of thoridazine were investigated on a mouse T-lymphoma cell line over-expressing the ATP-binding cassette, subfamily-B (MDR/TAP), member 1 (ABCB1) transporter (also known as P-glycoprotein) and on human PC3 prostate cancer cell line by 3-(4.5-dimethylthiazolyl-2)-2.5-diphenyl tetrazolium bromide (MTT) assay. The modulation of ABCB1 transporter activity was studied by rhodamine123 accumulation, the apoptosis-inducing effect was investigated using fluorescein isothiocyanate (FITC)-labeled annexin V and propidium iodide. RESULTS: The thioridazine racemic and (+) and (-) enantiomers were similarly effective. Drug accumulation by MDR mouse T-lymphoma cells was moderately modified in the presence of thioridazine derivatives. Thioridazine induced apoptosis of the MDR cancer cell line, but there was no significant apoptotic effect on the PC3 cell line. CONCLUSION: Apparently, the chirality of thioridazine has no importance in the inhibition of MDR phenotype of cancer cells. LA - English DB - MTMT ER - TY - GEN AU - Gárgyán, István AU - Varga, Endre AU - Csonka, Ákos AU - Sádt, Zoltán AU - Vági, Zsolt TI - Dynamic Locking Screw (DLS) alkalmazása elhúzódó humerus törésgyógyulás esetén PY - 2013 UR - https://m2.mtmt.hu/api/publication/2571256 ID - 2571256 N1 - [Előadás] LA - Hungarian DB - MTMT ER -