@misc{MTMT:34194528, title = {A periprotetikus és periimplantatikusfemur törések ellátása}, url = {https://m2.mtmt.hu/api/publication/34194528}, author = {Csonka, Ákos and Harangozó, Márk and Gárgyán, István}, unique-id = {34194528}, year = {2023} } @misc{MTMT:32891181, title = {A trigen intertan szegezések során tapasztalt Z effektus}, url = {https://m2.mtmt.hu/api/publication/32891181}, author = {Csonka, Ákos and Gárgyán, István and Török, László and Ecseri , Tamás}, unique-id = {32891181}, year = {2022} } @misc{MTMT:32891171, title = {Atipusos periprotetikus femurtörések összefüggése a hosszútávú biszfoszfonát terápiával}, url = {https://m2.mtmt.hu/api/publication/32891171}, author = {Dózsai, Dávid and Gárgyán, István and Csonka, Ákos and Bodzay, Tamás}, unique-id = {32891171}, year = {2022} } @misc{MTMT:32891142, title = {A LISS-DF alternatív alkalmazása}, url = {https://m2.mtmt.hu/api/publication/32891142}, author = {Ecseri , Tamás and Gárgyán, István and Török, László and Csonka, Ákos}, unique-id = {32891142}, year = {2022} } @article{MTMT:32766033, title = {Bisphosphonate therapy associated with bilateral atypical femoral fracture and delayed union}, url = {https://m2.mtmt.hu/api/publication/32766033}, author = {Gárgyán, István and Dózsai, Dávid and Csonka, István and Rárosi, Ferenc and Bodzay, Tamás and Csonka, Ákos}, doi = {10.52312/jdrs.2022.355}, journal-iso = {JOINT DIS RELAT SURG}, journal = {JOINT DISEASES AND RELATED SURGERY}, volume = {33}, unique-id = {32766033}, issn = {2687-4784}, year = {2022}, eissn = {2687-4792}, pages = {24-32}, orcid-numbers = {Rárosi, Ferenc/0000-0002-1014-9242; Bodzay, Tamás/0000-0001-8023-9596} } @article{MTMT:32924179, title = {Mitochondrial Dysfunction Affects the Synovium of Patients with Rheumatoid Arthritis and Osteoarthritis Differently}, url = {https://m2.mtmt.hu/api/publication/32924179}, author = {Jávor, Péter János and Mácsai, Attila and Butt, Edina and Baráth, Bálint and Jász, Dávid Kurszán and Horváth, Tamara and Baráth, Bence and Csonka, Ákos and Török, László and Varga, Endre and Hartmann, Petra}, doi = {10.3390/ijms23147553}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {32924179}, issn = {1661-6596}, abstract = {There is growing evidence regarding the role of mitochondrial dysfunction in osteoarthritis (OA) and rheumatoid arthritis (RA). However, quantitative comparison of synovial mitochondrial derangements in these main arthritis forms is missing. A prospective clinical study was conducted on adult patients undergoing knee surgery. Patients were allocated into RA and OA groups based on disease-specific clinical scores, while patients without arthritis served as controls. Synovial samples were subjected to high-resolution respirometry to analyze mitochondrial functions. From the total of 814 patients, 109 cases were enrolled into the study (24 RA, 47 OA, and 38 control patients) between 1 September 2019 and 31 December 2021. The decrease in complex I-linked respiration and dyscoupling of mitochondria were characteristics of RA patients, while both arthritis groups displayed reduced OxPhos activity compared to the control group. However, no significant difference was found in complex II-related activity between the OA and RA groups. The cytochrome C release and H2O2 formation were increased in both arthritis groups. Mitochondrial dysfunction was present in both arthritis groups; however, to a different extent. Consequently, mitochondrial protective agents may have major benefits for arthritis patients. Based on our current study, we recommend focusing on respiratory complex I in rheumatoid arthritis research.}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Baráth, Bálint/0000-0001-8837-2375; Jász, Dávid Kurszán/0000-0003-3700-5668; Horváth, Tamara/0000-0003-4437-9924; Baráth, Bence/0000-0001-5713-8471; Hartmann, Petra/0000-0002-4746-9792} } @article{MTMT:31794441, title = {Reversal of multidrug resistance and antitumor promoting activity of 3-oxo-6β-hydroxy- β-amyrin isolated from Pistacia integerrima}, url = {https://m2.mtmt.hu/api/publication/31794441}, author = {ABDUR, RAUF and SAUD, BAWAZEER and MUSLIM, RAZA and EMAN, EL-SHARKAWY and MD., HABIBUR RAHMAN and MOHAMED, A. EL-ESAWI and GHIAS, UDDIN and BINA, S. SIDDIQUI and ANEES, AHMED KHALIL and Molnár, József and Csonka, Ákos and Szabó, Diána and HAROON, KHAN and MOHAMMAD, S. MUBARAK and TAIBI, BEN HADDA and MUDYAWATI, KAMARUDDIN and SEEMA, PATEL}, doi = {10.32604/biocell.2021.013277}, journal-iso = {BIOCELL}, journal = {BIOCELL}, volume = {45}, unique-id = {31794441}, issn = {0327-9545}, year = {2021}, eissn = {1667-5746}, pages = {139-147} } @article{MTMT:32128211, title = {Effects of aging on proteasomal-ubiquitin system, oxidative stress balance and calcium homeostasis in middle-aged female rat colon}, url = {https://m2.mtmt.hu/api/publication/32128211}, author = {Almási, Nikoletta and Murlasits, Zsolt and Al-Awar, Amin and Csonka, Ákos and Dvorácskó, Szabolcs and Tömböly, Csaba and Török, Szilvia and Bester, D. and Pósa, Anikó and Varga, Csaba and Kupai, Krisztina}, doi = {10.1556/2060.2021.00012}, journal-iso = {PHYSIOL INT}, journal = {PHYSIOLOGY INTERNATIONAL}, volume = {108}, unique-id = {32128211}, issn = {2498-602X}, year = {2021}, eissn = {2677-0164}, pages = {27-42}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Murlasits, Zsolt/0000-0003-4101-3417; Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X; Kupai, Krisztina/0000-0002-0644-1718} } @article{MTMT:32470529, title = {Isolation of Bioactive Compounds from Pistacia integerrima with Promising Effects on Reverse Cancer Multidrug Resistance}, url = {https://m2.mtmt.hu/api/publication/32470529}, author = {Bawazeer, Sami and Rauf, Abdur and Mabkhot, Yahia N. and Al-Showiman, Salim S. and Patel, Seema and Gul, Somia and Raza, Muslim and Molnár, József and Szabó, Diána and Csonka, Ákos and Mujeeb-ur-, Rehman and Mubarak, Mohammad S. and Zengin, Gokhan and Ramadan, Mohamed Fawzy}, doi = {10.1134/S1068162021050204}, journal-iso = {RUSS J BIOORG CHEM+}, journal = {RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY}, volume = {47}, unique-id = {32470529}, issn = {1068-1620}, year = {2021}, eissn = {1608-330X}, pages = {997-1003} } @misc{MTMT:32305253, title = {Synoviális mitokondriumok légzési aktivitásának vizsgálata arthritisben}, url = {https://m2.mtmt.hu/api/publication/32305253}, author = {Butt, Edina and Jávor, Péter János and Csonka, Endre and Csonka, Ákos and Török, László and Varga, Endre and Hartmann, Petra}, unique-id = {32305253}, year = {2021}, orcid-numbers = {Hartmann, Petra/0000-0002-4746-9792} } @article{MTMT:32731979, title = {Atípusos femurtörések összefüggése a hosszantartó biszfoszfonát terápiával}, url = {https://m2.mtmt.hu/api/publication/32731979}, author = {Csonka, Ákos and Dózsai, Dávid and Gárgyán, István and Varga, Endre}, doi = {10.21755/MTO.2021.064.0104.005}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {64}, unique-id = {32731979}, issn = {1217-3231}, year = {2021}, pages = {49-58} } @article{MTMT:31189807, title = {Multidisciplinary treatment of a complicated crural degloving injury in a diabetic patient}, url = {https://m2.mtmt.hu/api/publication/31189807}, author = {Csonka, Ákos and Gárgyán, István and Varga, Endre}, doi = {10.1016/j.injury.2020.02.050}, journal-iso = {INJURY}, journal = {INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED}, volume = {52}, unique-id = {31189807}, issn = {0020-1383}, year = {2021}, eissn = {1879-0267}, pages = {S74-S77} } @misc{MTMT:32305203, title = {Hosszútávú biszfoszfonát terápia összefüggése a bilaterális atipusos femurtörésekkel és elhúzódó törésgyógyulással: multicenter study}, url = {https://m2.mtmt.hu/api/publication/32305203}, author = {Dózsai, Dávid and Gárgyán, István and Rárosi, Ferenc and Csonka, Ákos and Varga, Endre and Bodzay, Tamás}, unique-id = {32305203}, year = {2021}, orcid-numbers = {Rárosi, Ferenc/0000-0002-1014-9242} } @misc{MTMT:32305303, title = {Egy Volkmann törés tanulsága}, url = {https://m2.mtmt.hu/api/publication/32305303}, author = {Ecseri , Tamás and Gárgyán, István and Varga, Endre and Csonka, Ákos}, unique-id = {32305303}, year = {2021} } @article{MTMT:31652422, title = {Sigma-1 Receptor Engages an Anti-Inflammatory and Antioxidant Feedback Loop Mediated by Peroxiredoxin in Experimental Colitis}, url = {https://m2.mtmt.hu/api/publication/31652422}, author = {Almási, Nikoletta and Török, Szilvia and Valkusz, Zsuzsanna and Tajti, Máté and Csonka, Ákos and Murlasits, Zsolt and Pósa, Anikó and Varga, Csaba and Kupai, Krisztina}, doi = {10.3390/antiox9111081}, journal-iso = {ANTIOXIDANTS-BASEL}, journal = {ANTIOXIDANTS}, volume = {9}, unique-id = {31652422}, year = {2020}, eissn = {2076-3921}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Valkusz, Zsuzsanna/0000-0003-1928-6160; Murlasits, Zsolt/0000-0003-4101-3417; Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X; Kupai, Krisztina/0000-0002-0644-1718} } @article{MTMT:31340535, title = {Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis. Modulation of the UCHL-1, IL-6 Pathway}, url = {https://m2.mtmt.hu/api/publication/31340535}, author = {Almási, Nikoletta and Török, Szilvia and Dvorácskó, Szabolcs and Tömböly, Csaba and Csonka, Ákos and Baráth, Zoltán Lajos and Murlasits, Zsolt and Valkusz, Zsuzsanna and Pósa, Anikó and Varga, Csaba and Kupai, Krisztina}, doi = {10.3390/ijms21114046}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {21}, unique-id = {31340535}, issn = {1661-6596}, keywords = {sigma receptor; fluvoxamine; inflammation; UCHL-1}, year = {2020}, eissn = {1422-0067}, orcid-numbers = {Almási, Nikoletta/0000-0002-7371-5272; Baráth, Zoltán Lajos/0000-0003-0636-6313; Murlasits, Zsolt/0000-0003-4101-3417; Valkusz, Zsuzsanna/0000-0003-1928-6160; Pósa, Anikó/0000-0003-2167-2888; Varga, Csaba/0000-0002-2678-665X; Kupai, Krisztina/0000-0002-0644-1718} } @misc{MTMT:31592293, title = {A hosszantartó biszfoszfonát terápia összefüggése az atípusos periprotetikus femur töréssel}, url = {https://m2.mtmt.hu/api/publication/31592293}, author = {Csonka, Ákos and Dózsai, Dávid and Gárgyán, István and Ecseri , Tamás and Varga, Endre}, unique-id = {31592293}, year = {2020} } @article{MTMT:32032752, title = {Atípusos periprotetikus femurtörés}, url = {https://m2.mtmt.hu/api/publication/32032752}, author = {Dózsai, Dávid and Csonka, Ákos and Gárgyán, István and Varga, Endre}, doi = {10.21755/MTO.2020.063.0104.006}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {63}, unique-id = {32032752}, issn = {1217-3231}, year = {2020}, pages = {49-57} } @article{MTMT:31602868, title = {Atypical periprosthetic femoral fracture associated with long-term bisphosphonate therapy}, url = {https://m2.mtmt.hu/api/publication/31602868}, author = {Dózsai, Dávid and Ecseri , Tamás and Csonka, István and Gárgyán, István and Doró, Péter and Csonka, Ákos}, doi = {10.1186/s13018-020-01941-x}, journal-iso = {J ORTHOP SURG RES}, journal = {JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH}, volume = {15}, unique-id = {31602868}, issn = {1749-799X}, year = {2020}, eissn = {1749-799X}, orcid-numbers = {Doró, Péter/0000-0001-7784-6010} } @misc{MTMT:31592299, title = {A hosszantartó biszfoszfonát terápia összefüggése az atípusos femurtöréssel}, url = {https://m2.mtmt.hu/api/publication/31592299}, author = {Ecseri , Tamás and Csonka, Ákos and Gárgyán, István and Varga, Endre}, unique-id = {31592299}, year = {2020} } @article{MTMT:31564848, title = {Phenothiazines and Selenocompounds. A Potential Novel Combination Therapy of Multidrug Resistant Cancer}, url = {https://m2.mtmt.hu/api/publication/31564848}, author = {Gajdács, Márió and Nové, Márta and Csonka, Ákos and Varga, Borisz and SANMARTÍN, CARMEN and DOMÍNGUEZ-ÁLVAREZ, ENRIQUE and Spengler, Gabriella}, doi = {10.21873/anticanres.14495}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {40}, unique-id = {31564848}, issn = {0250-7005}, year = {2020}, eissn = {1791-7530}, pages = {4921-4928}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31311960, title = {The prognostic value of the hip screw position in trochanteric fractures}, url = {https://m2.mtmt.hu/api/publication/31311960}, author = {Gárgyán, István and Csonka, Ákos and Ecseri , Tamás}, journal-iso = {EUR J TRAUMA EMERG S}, journal = {EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY}, volume = {46}, unique-id = {31311960}, issn = {1863-9933}, year = {2020}, eissn = {1863-9941}, pages = {S178-S178} } @article{MTMT:31788305, title = {Novel perspectives of target-binding by the evolutionarily conserved PP4 phosphatase}, url = {https://m2.mtmt.hu/api/publication/31788305}, author = {Kármán, Zoltán and Réthi-Nagy, Zsuzsánna and Ábrahám, Edit and Ördögh, Lilla and Csonka, Ákos and Vilmos, Péter and Debski, Janusz and Dadlez, Michal and Glover, David M. and Lipinszki, Zoltán}, doi = {10.1098/rsob.200343}, journal-iso = {OPEN BIOL}, journal = {OPEN BIOLOGY}, volume = {10}, unique-id = {31788305}, abstract = {Protein phosphatase 4 (PP4) is an evolutionarily conserved and essential Ser/Thr phosphatase that regulates cell division, development and DNA repair in eukaryotes. The major form of PP4, present from yeast to human, is the PP4c-R2-R3 heterotrimeric complex. The R3 subunit is responsible for substrate-recognition via its EVH1 domain. In typical EVH1 domains, conserved phenylalanine, tyrosine and tryptophan residues form the specific recognition site for their target's proline-rich sequences. Here, we identify novel binding partners of the EVH1 domain of the Drosophila R3 subunit, Falafel, and demonstrate that instead of binding to proline-rich sequences this EVH1 variant specifically recognizes atypical ligands, namely the FxxP and MxPP short linear consensus motifs. This interaction is dependent on an exclusively conserved leucine that replaces the phenylalanine invariant of all canonical EVH1 domains. We propose that the EVH1 domain of PP4 represents a new class of the EVH1 family that can accommodate low proline content sequences, such as the FxxP motif. Finally, our data implicate the conserved Smk-1 domain of Falafel in target-binding. These findings greatly enhance our understanding of the substrate-recognition mechanisms and function of PP4. © 2020 The Authors.}, year = {2020}, eissn = {2046-2441}, orcid-numbers = {Lipinszki, Zoltán/0000-0002-2067-0832} } @misc{MTMT:30822780, title = {Reverz LISS-DF alkalmazása periprotetikus történések ellátása során}, url = {https://m2.mtmt.hu/api/publication/30822780}, author = {Csonka, Ákos and Gárgyán, István and Varga, Endre}, unique-id = {30822780}, year = {2019} } @misc{MTMT:30719872, title = {Infekciókontroll a szegedi traumatológiai klinikán}, url = {https://m2.mtmt.hu/api/publication/30719872}, author = {Csonka, Ákos and Varga, Endre}, unique-id = {30719872}, year = {2019} } @misc{MTMT:30719868, title = {Atípusos femurtörések kezelése}, url = {https://m2.mtmt.hu/api/publication/30719868}, author = {Csonka, Ákos}, unique-id = {30719868}, year = {2019} } @misc{MTMT:30705023, title = {Nehézségek az osteoporoticus humerus törések ellátásában}, url = {https://m2.mtmt.hu/api/publication/30705023}, author = {Csonka, Ákos and Kovács, Mihály and Gárgyán, István and Horváth, Attila and Varga, Endre}, unique-id = {30705023}, year = {2019}, pages = {8} } @misc{MTMT:30705018, title = {Mellkasi sérültek drenázsadatainak vizsgálata}, url = {https://m2.mtmt.hu/api/publication/30705018}, author = {Csonka, Ákos and Dózsai, Dávid and Gárgyán, István and Csonka, István and Ecseri , Tamás and Varga, Endre}, unique-id = {30705018}, year = {2019}, pages = {6} } @article{MTMT:30466023, title = {A combfejcsavar helyzetének prognosztikai jelentősége a csípőtáji törések esetén [The prognostic value of the hip screw position in intertrochanteric fractures]}, url = {https://m2.mtmt.hu/api/publication/30466023}, author = {Csonka, Ákos and Ecseri , Tamás and Dózsai, Dávid and Csonka, István and Gárgyán, István and Varga, Endre}, doi = {10.1556/650.2019.31328}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {160}, unique-id = {30466023}, issn = {0030-6002}, year = {2019}, eissn = {1788-6120}, pages = {338-342} } @article{MTMT:30418766, title = {Mellkasi sérültek drenázsadatainak vizsgálata [Drainage data analysis of chest-injured patients]}, url = {https://m2.mtmt.hu/api/publication/30418766}, author = {Csonka, Ákos and Dózsai, Dávid and Ecseri , Tamás and Gárgyán, István and Csonka, István and Varga, Endre}, doi = {10.1556/650.2019.31252}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {160}, unique-id = {30418766}, issn = {0030-6002}, year = {2019}, eissn = {1788-6120}, pages = {172-178} } @misc{MTMT:30822776, title = {Mellkascsövezés komplikációi és megoldásai mellkasi sérülések esetén}, url = {https://m2.mtmt.hu/api/publication/30822776}, author = {Dózsai, Dávid and Csonka, Ákos and Gárgyán, István and Varga, Endre}, unique-id = {30822776}, year = {2019} } @misc{MTMT:30705024, title = {Tibia álízületek kezelése Klinikánkon}, url = {https://m2.mtmt.hu/api/publication/30705024}, author = {Tóth, Zoltán and Csonka, Ákos and Varga, Endre}, unique-id = {30705024}, year = {2019}, pages = {12} } @article{MTMT:3341125, title = {In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta}, url = {https://m2.mtmt.hu/api/publication/3341125}, author = {Cyboran-Mikolajczyk, S and Csonka, Ákos and Molnár, József and Szabó, Diána and Oszmianski, J and Kleszczynska, H}, doi = {10.1515/pjfns-2017-0021}, journal-iso = {POLISH J FOOD NUTR SCI}, journal = {POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES}, volume = {68}, unique-id = {3341125}, issn = {1230-0322}, year = {2018}, eissn = {2083-6007}, pages = {171-177} } @article{MTMT:3352161, title = {Anemia among hospitalized elderly patients}, url = {https://m2.mtmt.hu/api/publication/3352161}, author = {Csatordai, Márta and Bor, Andrea and Gyimesi, Nóra and Matuz, Mária and Csonka, Ákos and Gárgyán, István and Doró, Péter}, doi = {10.1136/ejhpharm-2018-eahpconf.355}, journal-iso = {EUR J HOSP PHARM SCI PRACT}, journal = {EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE}, volume = {25}, unique-id = {3352161}, issn = {2047-9956}, year = {2018}, eissn = {2047-9964}, pages = {A165-A165}, orcid-numbers = {Matuz, Mária/0000-0002-7877-2399; Doró, Péter/0000-0001-7784-6010} } @misc{MTMT:3364861, title = {A Tip-Apex Distance (TAD) prognosztikai jelentősége a csípőtáji törések esetén}, url = {https://m2.mtmt.hu/api/publication/3364861}, author = {Csonka, Ákos and Ecseri , Tamás and Gárgyán, István and Varga, Endre}, unique-id = {3364861}, year = {2018} } @misc{MTMT:3392706, title = {Bordatörések műtéti kezelése MATRIXRIB TM rendszerrel}, url = {https://m2.mtmt.hu/api/publication/3392706}, author = {Gárgyán, István and Vági, Zsolt and Csonka, Ákos and Furák, József and Tánczos, Krisztián and Varga, Endre}, unique-id = {3392706}, year = {2018}, orcid-numbers = {Furák, József/0000-0002-7224-1642} } @article{MTMT:3340031, title = {Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria}, url = {https://m2.mtmt.hu/api/publication/3340031}, author = {Kincses, Annamária and Varga, Borisz and Csonka, Ákos and Sancha, S and Mulhovo, S and Madureira, AM and Ferreira, MU and Spengler, Gabriella}, doi = {10.1002/ptr.6042}, journal-iso = {PHYTOTHER RES}, journal = {PHYTOTHERAPY RESEARCH}, volume = {32}, unique-id = {3340031}, issn = {0951-418X}, abstract = {Cleistochlamys kirkii (Benth) Oliv. (Annonaceae) is a medicinal plant traditionally used in Mozambique to treat infectious diseases. The aim of this study was to find resistance modifiers in C. kirkii for Gram-positive and Gram-negative model bacterial strains. One of the most important resistance mechanisms in bacteria is the efflux pump-related multidrug resistance. Therefore, polycarpol (1), three C-benzylated flavanones (2-4), and acetylmelodorinol (5) were evaluated for their multidrug resistance-reverting activity on methicillin-susceptible and methicillin-resistant Staphylococcus aureus and Escherichia coli AG100 and AG100 A strains overexpressing and lacking the AcrAB-TolC efflux pump system. The combined effects of antibiotics and compounds (2 and 4) were also assessed by using the checkerboard microdilution method in both S. aureus strains. The relative gene expression of the efflux pump genes was determined by real-time reverse transcriptase quantitative polymerase chain reaction. The inhibition of quorum sensing was also investigated. The combined effect of the antibiotics and compound 2 or 4 on the methicillin-sensitive S. aureus resulted in synergism. The most active compounds 2 and 4 increased the expression of the efflux pump genes. These results suggested that C. kirkii constituents could be effective adjuvants in the antibiotic treatment of infections.}, year = {2018}, eissn = {1099-1573}, pages = {1039-1046}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3370144, title = {Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus}, url = {https://m2.mtmt.hu/api/publication/3370144}, author = {Rauf, A and Shaheen, U and Raza, M and Uddin, G and Hadda, TB and Mabkhot, YN and Jehan, N and Ahmad, B and Raza, S and Molnár, József and Csonka, Ákos and Szabó, Diána}, journal-iso = {PAK J PHARM SCI}, journal = {PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {31}, unique-id = {3370144}, issn = {1011-601X}, abstract = {A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks.}, year = {2018}, eissn = {1011-601X}, pages = {821-825} } @misc{MTMT:3392740, title = {Hogyan csináljuk mi?/Avagy a csípőprotézisek körül kialakult femur törések ellátása klinikánkon.}, url = {https://m2.mtmt.hu/api/publication/3392740}, author = {Sádt, Zoltán and Csonka, Ákos and Császár, József and Fetter, Gábor and Pintér, Sándor and Varga, Endre}, unique-id = {3392740}, year = {2018} } @misc{MTMT:3364869, title = {TFNA szegezés — Az univerzális implantátum?}, url = {https://m2.mtmt.hu/api/publication/3364869}, author = {Varga, Endre and Mácsai, Attila and Gárgyán, István and Csonka, Ákos}, unique-id = {3364869}, year = {2018} } @article{MTMT:3284046, title = {CONSTITUENTS OF CLEISTOCHLAMYS KIRKII AS ANTIBACTERIALS AND EFFLUX PUMP INHIBITORS}, url = {https://m2.mtmt.hu/api/publication/3284046}, author = {Kincses, Annamária and Spengler, Gabriella and Szilvia, Varga and Varga, Borisz and Csonka, Ákos and Shirley, Sancha and Silva, Mulhovo and Ana, Margarida Madureira and Maria-José, U Ferreira}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3284046}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {134-135}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3240653, title = {Isolation of Chlorogenic Acid from Soil Borne Fungi Screlotium rolfsii, their Reversal of Multidrug Resistance and anti-proliferative in Mouse Lymphoma cells}, url = {https://m2.mtmt.hu/api/publication/3240653}, author = {Bashir, Ahmad and Muhammad, Rizwan and Abdur, Rauf and Muslim, Raza and Shumaila, Bashir and Molnár, József and Csonka, Ákos and Szabó, Diána and Mohammad, S Mubarak and Mah, Noor and Bina, S Siddiqui}, doi = {10.2174/1573406413666170612110443}, journal-iso = {MED CHEM}, journal = {MEDICINAL CHEMISTRY}, volume = {13}, unique-id = {3240653}, issn = {1573-4064}, abstract = {BACKGROUND: Fungi performing a wide range of function in soil by secreting low molecular weight compound known as secondary metabolites. S. rolfsii is a soil borne phytopathogenic fungi was used for the production of bioactive compounds. OBJECTIVE: The present study belongs to evaluate the anticancer potentials of a secondary metabolites isolated from S. rolfsii, their multidrug resistance (MDR), and molecular docking study. METHOD: (1S,3R,4R,5R,E)-3-(3-(3,4-Dihydroxyphenyl)acryloyloxy)-1,4,5 trihydroxycyclohexanecarboxylic acid (1), or best known as chlorogenic acid, was isolated from the ethyl acetate fraction of crude secondary metabolites produced by the soil borne Fungus Screlotium rolfsii. Structure of chlorogenic acid (1) was confirmed by means of FT-IR, 1H NMR, 13C NMR, and mass spectrometry as well as by melting point. RESULTS: Effect of compound 1 on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) against cancer cells was evaluated with a rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma. Compound 1 was also evaluated for Anti-proliferative effect on the L5178 mouse T-cell lymphoma cell line. CONCLUSION: Results from the present investigation revealed that compound 1 exhibits excellent MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Compound 1 also showed anti-proliferative effect on L5178Y mouse T-lymphoma cell line.}, year = {2017}, eissn = {1875-6638}, pages = {721-726} } @article{MTMT:3283951, title = {Antibacterial Activity of Hydrazone-Based Transition Metal Complexes}, url = {https://m2.mtmt.hu/api/publication/3283951}, author = {Berta, Barta Holló and József, Magyari and Kincses, Annamária and Gajdács, Márió and Nové, Márta and Varga, Borisz and Csonka, Ákos and Spengler, Gabriella and Katalin, Mészáros Szécsényi}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3283951}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {112-112}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3271829, title = {Possible Biological and Clinical Applications of Phenothiazines}, url = {https://m2.mtmt.hu/api/publication/3271829}, author = {Varga, Borisz and Csonka, Ákos and Csonka, Andrea and Molnár, József and Leonard, Amaral and Spengler, Gabriella}, doi = {10.21873/anticanres.12045}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {37}, unique-id = {3271829}, issn = {0250-7005}, keywords = {Animals; Humans; Antineoplastic Agents/*pharmacology; Infection/drug therapy; Neoplasms/drug therapy; Anti-Infective Agents/*pharmacology; Phenothiazines/*pharmacology; Antipsychotic Agents/*pharmacology; Mental Disorders/drug therapy}, year = {2017}, eissn = {1791-7530}, pages = {5983-5993}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3317060, title = {Polypharmacy among hospitalized, elderly patients}, url = {https://m2.mtmt.hu/api/publication/3317060}, author = {Csatordai, Márta and Bor, Andrea and Szalai, Gábor and Csonka, Ákos and Gárgyán, István and Doró, Péter}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {87}, unique-id = {3317060}, issn = {0001-6659}, year = {2017}, eissn = {1587-1495}, pages = {227-227}, orcid-numbers = {Doró, Péter/0000-0001-7784-6010} } @article{MTMT:3221190, title = {Potenciálisan nem megfelelő gyógyszerek alkalmazása idős, kórházi betegek körében}, url = {https://m2.mtmt.hu/api/publication/3221190}, author = {Csatordai, Márta and Bor, Andrea and Gyimesi, Nóra and Csonka, Ákos and Doró, Géza and Gárgyán, István and Doró, Péter}, journal-iso = {GYÓGYSZERÉSZET}, journal = {GYÓGYSZERÉSZET}, volume = {61}, unique-id = {3221190}, issn = {0017-6036}, year = {2017}, pages = {S15}, orcid-numbers = {Doró, Péter/0000-0001-7784-6010} } @misc{MTMT:3321558, title = {Atípusos femurtörések ellátása}, url = {https://m2.mtmt.hu/api/publication/3321558}, author = {Csonka, Ákos and Gárgyán, István and Doró, Péter and Sádt, Zoltán and Vági, Zsolt and Varga, Endre}, unique-id = {3321558}, year = {2017} } @misc{MTMT:3240916, title = {A típusos femurtörések kezelése}, url = {https://m2.mtmt.hu/api/publication/3240916}, author = {Csonka, Ákos and Gárgyán, István and Doró, Péter and Sádt, Zoltán and Vági, Zsolt and Varga, Endre}, unique-id = {3240916}, year = {2017}, pages = {26}, orcid-numbers = {Doró, Péter/0000-0001-7784-6010} } @misc{MTMT:3240883, title = {A hemiarthroplasticaval kezelt combnyaktörések eredményei klinikánkon}, url = {https://m2.mtmt.hu/api/publication/3240883}, author = {Faludi, László and Csonka, Ákos and Varga, Endre and Gárgyán, István}, unique-id = {3240883}, year = {2017}, pages = {19} } @article{MTMT:3381158, title = {Bordatörések műtéti kezelése MatrixRIB(TM) rendszerrel}, url = {https://m2.mtmt.hu/api/publication/3381158}, author = {Gárgyán, István and Vági, Zsolt and Csonka, Ákos and Furák, József and Tánczos, Krisztián and Varga, Endre}, doi = {10.21755/MTO.2017.060.0304.001}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {60}, unique-id = {3381158}, issn = {1217-3231}, year = {2017}, pages = {79-87}, orcid-numbers = {Furák, József/0000-0002-7224-1642} } @misc{MTMT:3278167, title = {Az időskori osteoporotikus medencetörések diagnosztikája}, url = {https://m2.mtmt.hu/api/publication/3278167}, author = {Gárgyán, István and Vági, Zsolt and Csonka, Ákos and Varga, Endre}, unique-id = {3278167}, year = {2017} } @misc{MTMT:3240873, title = {Időskori osteoporoticus medencetörések diagnosztikája}, url = {https://m2.mtmt.hu/api/publication/3240873}, author = {Gárgyán, István and Vági, Zsolt and Csonka, Ákos and Varga, Endre}, unique-id = {3240873}, year = {2017}, pages = {18} } @CONFERENCE{MTMT:3317455, title = {Potentially inappropriate medication use among elderly, hospitalized patients}, url = {https://m2.mtmt.hu/api/publication/3317455}, author = {Csatordai, Márta and Benkő, Ria and Bor, Andrea and Csonka, Ákos and Géza, Doró and Gárgyán, István and Doró, Péter}, booktitle = {European Drug Utilisation Research Group (EuroDURG) Conference 2017: Program and Abstracts}, unique-id = {3317455}, year = {2017}, pages = {102-102}, orcid-numbers = {Benkő, Ria/0000-0002-8009-8962; Doró, Péter/0000-0001-7784-6010} } @article{MTMT:3073568, title = {Isolation and Structure Elucidation, Molecular Docking Studies of Screlotiumol from Soil Borne Fungi Screlotium rolfsii and their Reversal of Multidrug Resistance in Mouse Lymphoma Cells}, url = {https://m2.mtmt.hu/api/publication/3073568}, author = {Ahmad, B and Rizwan, M and Rauf, A and Raza, M and Azam, S and Bashir, S and Molnár, József and Csonka, Ákos and Szabó, Diána}, doi = {10.7314/APJCP.2016.17.4.2083}, journal-iso = {ASIAN PAC J CANCER P}, journal = {ASIAN PACIFIC JOURNAL OF CANCER PREVENTION}, volume = {17}, unique-id = {3073568}, issn = {1513-7368}, abstract = {A new compound namely (13-(3,3-dihydroxypropyl)-1,6-dihydroxy-3,4-dihydro-1H-isochromen-8(5H)-one (1) was isolated from an ethyl acetate extract of the borne fungi Screlotium rolfsii. Its chemical structure was elucidated by spectroscopic analysis. Screlotiumol 1 were evaluated for their effects on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) of the soil borne fungi. The multidrug resistant P-glycoprotein is a target for chemotherapeutic drugs in cancer cells. In the present study rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma which showed excellent MDR reversing effect in a dose dependent manner against mouse T-lymphoma cell line. Moreover, molecular docking studies of compound-1 also showed better results as compared with the standard. Therefore the preliminary results obtained from this study suggest that screlotiumol 1 could be used as a potential agent for the treatment of cancer.}, year = {2016}, eissn = {2476-762X}, pages = {2083-2087} } @article{MTMT:3045538, title = {Risks of surgical intervention in patients taking oral anticoagulants}, url = {https://m2.mtmt.hu/api/publication/3045538}, author = {Bor, Andrea and Soós, Gyöngyvér and Csatordai, Márta and Gyimesi, Nóra and Csonka, Ákos and Doró, G and Gárgyán, István and Doró, Péter}, doi = {10.1136/ejhpharm-2016-000875.117}, journal-iso = {EUR J HOSP PHARM SCI PRACT}, journal = {EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE}, volume = {23}, unique-id = {3045538}, issn = {2047-9956}, year = {2016}, eissn = {2047-9964}, pages = {51-52}, orcid-numbers = {Doró, Péter/0000-0001-7784-6010} } @article{MTMT:3110735, title = {Rezisztenciamódosítók összehasonlítása multidrog-rezisztens prosztata-, egérlymphoma- és vastagbélrák-sejtvonalakon [Comparison of the effect of multidrug resistance modifiers on prostate cancer, mouse lymphoma and colon cancer cells]}, url = {https://m2.mtmt.hu/api/publication/3110735}, author = {Csonka, Ákos}, doi = {10.1556/650.2016.30536}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {157}, unique-id = {3110735}, issn = {0030-6002}, abstract = {INTRODUCTION: The reason for unsuccessful tumor chemotherapy is related to multidrug resistance. An important factor is the overexpression of efflux pumps, such as P-glycoprotein. AIM: Amino- and amide-substituted steroid compounds and phenothiazine derivatives were investigated in tumor models in vitro. METHOD: The inhibition of P-glycoprotein was evaluated by flow cytometry and the interaction of these compounds with doxorubicin was investigated as well. Molecular docking was used to estimate the binding energies of the compounds to P-glycoprotein. RESULTS: The aminosteroids showed anticancer activity on multidrug resistant mouse T-lymphoma and prostate cancer cell lines. The combination of steroids and doxorubicin potentiated its effect in hormone resistant prostate cancer cells. Among the N-hydroxyalkyl-2-aminophenothiazines, secondary amines exhibited anticancer effects on multidrug resistant colon adenocarcinoma cells. CONCLUSIONS: The tested phenothiazine and steroid derivatives showed potent anticancer activity, furthermore, the stereoisomerism of thioridazine did not play a role in the antitumor properties. Neither steroids nor thioridazine influenced apoptosis in hormone resistant cells. Orv. Hetil., 2016, 157(37), 1489-1495.}, year = {2016}, eissn = {1788-6120}, pages = {1489-1495} } @article{MTMT:3026838, title = {Operative management of bilateral Salter-Harris type III fractures of the proximal phalanges of the great toes of a 10-year-old female ballet dancer. a case report}, url = {https://m2.mtmt.hu/api/publication/3026838}, author = {Csonka, Ákos and Sikarinkul, E and Gárgyán, István and Boa, Kristóf and Varga, Endre}, doi = {10.1097/BPB.0000000000000284}, journal-iso = {J PEDIATR ORTHOP B}, journal = {JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B}, volume = {25}, unique-id = {3026838}, issn = {1060-152X}, abstract = {Differentiation between the normal variant cleft epiphysis and Salter-Harris type III fracture of the first proximal phalanges of the foot in children might be challenging. The authors describe a case of a 10-year-old ballet dancer girl with bilateral epiphyseal segmentation of the first proximal phalanges of the foot, unresponsive to conservative treatment. Considered a nonhealing stress-induced fracture, operative treatment with closed reduction and Herbert screw insertion was chosen on both sides. Complete union was achieved, with significant reduction of pain. The presented case suggests that internal fixation can be a viable option in the treatment of the problem.}, year = {2016}, eissn = {1473-5865}, pages = {393-396}, orcid-numbers = {Boa, Kristóf/0000-0002-6534-1434} } @article{MTMT:3293179, title = {Megoldást jelent-e a szögstabil implantátumok bevezetése a proximalis humerus törések ellátásában?}, url = {https://m2.mtmt.hu/api/publication/3293179}, author = {Csonka, Ákos and Gárgyán, István and Böröndy, János and Boa, Kristóf and Varga, Endre}, doi = {10.21755/MTO.2016.059.0304.003}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {59}, unique-id = {3293179}, issn = {1217-3231}, year = {2016}, pages = {107-112}, orcid-numbers = {Boa, Kristóf/0000-0002-6534-1434} } @article{MTMT:3293175, title = {Bicondylaris tibia plató törések kettős lemezelése}, url = {https://m2.mtmt.hu/api/publication/3293175}, author = {Csonka, Ákos and Gárgyán, István and Boa, Kristóf and Sádt, Zoltán and Varga, Endre}, doi = {10.21755/MTO.2016.059.0304.002}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {59}, unique-id = {3293175}, issn = {1217-3231}, year = {2016}, pages = {99-105}, orcid-numbers = {Boa, Kristóf/0000-0002-6534-1434} } @mastersthesis{MTMT:3008920, title = {Comparison of the effects of resistance modifiers on prostate cancer, mouse lymphoma and colon cancer cells}, url = {https://m2.mtmt.hu/api/publication/3008920}, author = {Csonka, Ákos}, doi = {10.14232/phd.2835}, publisher = {SZTE}, unique-id = {3008920}, year = {2016} } @article{MTMT:3006445, title = {1-[3-(2-Hydroxyethylsulfanyl)propanoyl]-3,5-bis(benzylidene)-4-piperidones: A novel cluster of P-glycoprotein dependent multidrug resistance modulators}, url = {https://m2.mtmt.hu/api/publication/3006445}, author = {Das, U and Pati, HN and Baráth, Zoltán Lajos and Csonka, Ákos and Molnár, József and Dimmock, JR}, doi = {10.1016/j.bmcl.2016.01.005}, journal-iso = {BIOORG MED CHEM LETT}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, volume = {26}, unique-id = {3006445}, issn = {0960-894X}, abstract = {A series of 1-[3-(2-hydroxyethylsulfanyl)propanoyl]-3,5-bis(benzylidene)-4-piperidones 4a-e display promising P-glycoprotein dependent multidrug resistance (MDR) revertant properties and are significantly more potent than a reference drug verapamil when evaluated against L-5178Y MDR lymphoma cells. These dienones may be referred to as dual agents having both MDR revertant properties and tumour-selective cytotoxicity. In particular, 3,5-bis(4-chlorobenzylidene)-1-[3-(2-hydroxyethylsulfanyl]propanoyl-4-piperidone 4d emerged as a lead molecule for further development based on its MDR revertant properties, cytotoxic potencies and tumour-selective toxicity. The structure-activity relationships reveal important structural requirements for further designing of potent MDR revertants.}, year = {2016}, eissn = {1464-3405}, pages = {1319-1321}, orcid-numbers = {Baráth, Zoltán Lajos/0000-0003-0636-6313} } @misc{MTMT:3115859, title = {A hemiarthroplasticaval kezelt combnyaktörések eredményei klinikánkon}, url = {https://m2.mtmt.hu/api/publication/3115859}, author = {Faludi, László and Csonka, Ákos and Gárgyán, István and Varga, Endre}, unique-id = {3115859}, year = {2016} } @article{MTMT:3108350, title = {A hemiarthroplasticaval kezelt combnyaktörések eredményei klinikánkon}, url = {https://m2.mtmt.hu/api/publication/3108350}, author = {Faludi, László and Csonka, Ákos and Gárgyán, István and Varga, Endre}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {59}, unique-id = {3108350}, issn = {1217-3231}, year = {2016}, pages = {109-109} } @misc{MTMT:3115861, title = {Tömeges migráció Magyarországon - Klinikánk tapasztalatai}, url = {https://m2.mtmt.hu/api/publication/3115861}, author = {Gárgyán, István and Csonka, Ákos and Varga, Endre}, unique-id = {3115861}, year = {2016} } @article{MTMT:3108339, title = {Tömeges migráció Magyarországon - Klinikánk tapasztalatai}, url = {https://m2.mtmt.hu/api/publication/3108339}, author = {Gárgyán, István and Csonka, Ákos and Varga, Endre}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {59}, unique-id = {3108339}, issn = {1217-3231}, year = {2016}, pages = {146-147} } @article{MTMT:3073567, title = {Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima.}, url = {https://m2.mtmt.hu/api/publication/3073567}, author = {Rauf, A and Uddin, G and Raza, M and Ahmad, A and Jehan, N and Ahmad, B and Nisar, M and Molnár, József and Csonka, Ákos and Szabó, Diána and Khan, A and Farooq, U and Noor, M}, doi = {10.7314/APJCP.2016.17.4.2311}, journal-iso = {ASIAN PAC J CANCER P}, journal = {ASIAN PACIFIC JOURNAL OF CANCER PREVENTION}, volume = {17}, unique-id = {3073567}, issn = {1513-7368}, abstract = {Pistagremic acid (PA) is a bioactive triterpenoid isolated from various parts of Pistacia integerrima plants. The aim of this research was to investigate PA for reversion of multidrug resistant (MDR) mediated by P-glycoprotein using rhodamine-123 exclusion study on a multidrug resistant human ABCB1 (ATP-binding cassette, sub-family B, member 1) gene-transfected mouse T-lymphoma cell line in vitro. Results were similar to those with verapamil as a positive control. Docking studies of PA and standard Rhodamine123 were carried out against a P-gp crystal structure which showed satisfactory results. Actually, PA cannot bind exactly where co-crystallized ligand of P-gp is already present. However, the docking study predicted that if a compound gives a lesser score then it may have some potency. The docking scores of PA and Rhodamine were similar. Therefore, we can conclude that there are certain important chemical features of PA which are responsible for the inhibiting potency of P-gp.}, year = {2016}, eissn = {2476-762X}, pages = {2311-2314} } @article{MTMT:3013412, title = {Reversal of Multidrug Resistance in Mouse Lymphoma Cells by Extracts and Flavonoids from Pistacia integerrima}, url = {https://m2.mtmt.hu/api/publication/3013412}, author = {Rauf, A and Uddin, G and Raza, M and Ahmad, B and Jehan, N and Siddiqui, BS and Molnár, József and Csonka, Ákos and Szabó, Diána}, doi = {10.7314/APJCP.2016.17.1.51}, journal-iso = {ASIAN PAC J CANCER P}, journal = {ASIAN PACIFIC JOURNAL OF CANCER PREVENTION}, volume = {17}, unique-id = {3013412}, issn = {1513-7368}, abstract = {Phytochemical investigation of Pistacia integerrima has highlighted isolation of two known compounds naringenin (1) and dihydrokaempferol (2). A crude extract and these isolated compounds were here evaluated for their effects on reversion of multidrug resistance (MDR) mediated by P-glycoprotein (P-gp). The multidrug resistance P-glycoprotein is a target for chemotherapeutic drugs from cancer cells. In the present study rhodamine- 123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma cells showed excellent MDR reversing effects in a dose dependent manner. In-silico molecular docking investigations demonstrated a common binding site for Rhodamine123, and compounds naringenin and dihydrokaempferol. Our results showed that the relative docking energies estimated by docking softwares were in satisfactory correlation with the experimental activities. Preliminary interaction profile of P-gp docked complexes were also analysed in order to understand the nature of binding modes of these compounds. Our computational investigation suggested that the compounds interactions with the hydrophobic pocket of P-gp are mainly related to the inhibitory activity. Moreover this study s a platform for the discovery of novel natural compounds from herbal origin, as inhibitor molecules against the P-glycoprotein for the treatment of cancer.}, year = {2016}, eissn = {2476-762X}, pages = {51-55} } @misc{MTMT:3115863, title = {A csípőtáji törések intramedullaris szegezésének problémái}, url = {https://m2.mtmt.hu/api/publication/3115863}, author = {Sádt, Zoltán and Körmöndi, Sándor Pál and Horváth, Attila and Süveges, Gábor and Csonka, Ákos and Varga, Endre}, unique-id = {3115863}, year = {2016} } @article{MTMT:3108353, title = {A csípőtáji törések intramedullaris szegezésének problémái}, url = {https://m2.mtmt.hu/api/publication/3108353}, author = {Sádt, Zoltán and Körmöndi, Sándor Pál and Horváth, Attila and Süveges, Gábor and Csonka, Ákos and Varga, Endre}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {59}, unique-id = {3108353}, issn = {1217-3231}, year = {2016}, pages = {105-106} } @article{MTMT:3135012, title = {The Anticancer Activity of the Old Neuroleptic Phenothiazine-type Drug Thioridazine}, url = {https://m2.mtmt.hu/api/publication/3135012}, author = {Spengler, Gabriella and Csonka, Ákos and Molnár, József and Amaral, L}, doi = {10.21873/anticanres.11153}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {36}, unique-id = {3135012}, issn = {0250-7005}, abstract = {Thioridazine (TZ), an antipsychotic drug, renders multidrug-resistant (MDR) cancer cells susceptible to cytotoxic agents to which they were initially resistant, has anti-prolilferative activity and apoptosis-inducing properties in various tumor cell lines and cancer stem cells. Whereas the anti-proliferative activity takes place at high concentrations that ensure the intercalation of the compound between nucleic bases (especially rich in G/C bases), much lower concentrations inhibit the export function of the ABCB1 (P-glycoprotein), which is responsible for the MDR phenotype of the cancer cell. The co-administration of TZ with doxorubicin inhibits efflux of doxorubicin and, hence, increases the intracellular concentration of anticancer drug. The (+) and (-) enantiomers of TZ have the same activities as TZ. The main focus of this review is to present extensive evidence provided by our work, confirmed by much later studies, as it supports adjuvant use of TZ with an anticancer drug for MDR cancer therapy.}, year = {2016}, eissn = {1791-7530}, pages = {5701-5706}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2879234, title = {Substituted steroidal compounds containing amino and amido groups reverse multidrug resistance of mouse T-lymphoma and two human prostate cancer cell lines in vitro}, url = {https://m2.mtmt.hu/api/publication/2879234}, author = {Csonka, Ákos and Hamdoun, S and Spengler, Gabriella and Martins, Ana and Vincze, I and Efferth, T and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {35}, unique-id = {2879234}, issn = {0250-7005}, abstract = {BACKGROUND: Resistance to chemotherapy is a main problem in cancer. The search for new effective compounds that can increase sensitivity of resistant cells to existing chemotherapeutics is an urgent need. In previous studies, it has been demonstrated that steroid derivatives showed promising results concerning their capacity to modulate resistance of multidrug-resistant cell lines. MATERIALS AND METHODS: Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multidrug resistance, apoptosis induction, and interaction with doxorubicin on multidrug resistant human ATP-binding cassette, sub-family B, member 1 (ABCB1) gene-transfected mouse T-lymphoma cell line, and human PC-3 and LNCaP prostate cancer cell lines in vitro. The steroidal interaction with P-glycoprotein (ABCB1) was investigated by molecular docking. RESULTS: Both the activity of steroid derivatives on inhibition of the ABCB1 pump and their interaction with doxorubicin are dependent on the substituent groups of the investigated steroidal structures. Even though the investigated steroid derivatives were found to have limited antiproliferative effect on the three different cancer cell lines, in combination with doxorubicin, most of them acted as good potentiators. The binding energies from molecular docking ranged from -6.43 to -9.88 kcal/mol. The predicted inhibition constants ranged from 0.1 to 10.1 muM. A significant negative correlation was found between binding energy and fluorescence activity ratio (R=-0.5, p=0.015). CONCLUSION: The effective compounds can be candidates of model molecules for possible application in the treatment of multidrug resistant cancer in rational drug design.}, year = {2015}, eissn = {1791-7530}, pages = {2105-2112}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:2910024, title = {TFNA - ÚJ LEHETŐSÉG A PERTROCHANTER TÖRÉSEK ELLÁTÁSÁBAN}, url = {https://m2.mtmt.hu/api/publication/2910024}, author = {Csonka, Ákos and Gárgyán, István and Varga, Endre}, unique-id = {2910024}, year = {2015} } @CONFERENCE{MTMT:2889650, title = {Orális antikoaguláns kezelésben részesülők műtéti kockázatai}, url = {https://m2.mtmt.hu/api/publication/2889650}, author = {Doró, Péter and Bor, Andrea and Gyimesi, Nóra and Csatordai, Márta and Csonka, Ákos and Doró, Géza and Gárgyán, István}, booktitle = {Kórházi Gyógyszerészek XX. Kongresszusa}, unique-id = {2889650}, year = {2015}, pages = {50-50}, orcid-numbers = {Doró, Péter/0000-0001-7784-6010} } @article{MTMT:3060497, title = {Periprotetikus distalis femurtörések minimál invazív lemezes rögzítése totál térdprotézis beültetése után}, url = {https://m2.mtmt.hu/api/publication/3060497}, author = {Gárgyán, István and Csonka, Ákos and Boa, Kristóf and Körmöndi, Sándor Pál and Tóth, Kálmán and Varga, Endre}, doi = {10.21755/MTO.2015.058.0004.002}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {58}, unique-id = {3060497}, issn = {1217-3231}, year = {2015}, pages = {209-216}, orcid-numbers = {Boa, Kristóf/0000-0002-6534-1434} } @article{MTMT:3060492, title = {ß-tricalcium phosphate granulátum alkalmazása a tibia plató törések kezelésében}, url = {https://m2.mtmt.hu/api/publication/3060492}, author = {Gárgyán, István and Vági, Zsolt and Csonka, Ákos and Boa, Kristóf and Varga, Endre}, doi = {10.21755/MTO.2015.058.0004.001}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {58}, unique-id = {3060492}, issn = {1217-3231}, year = {2015}, pages = {201-207}, orcid-numbers = {Boa, Kristóf/0000-0002-6534-1434} } @article{MTMT:2927598, title = {Időskori szeméremcsonttörések, okkult hátsó gyűrű sérülések vizsgálata}, url = {https://m2.mtmt.hu/api/publication/2927598}, author = {Gárgyán, István and Csonka, Ákos and Kószó, Balázs and Vági, Zsolt and Berényi, Zsolt and Varga, Endre}, doi = {10.21755/MTO.2015.058.0001.002}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {58}, unique-id = {2927598}, issn = {1217-3231}, year = {2015}, pages = {19-25} } @article{MTMT:2892375, title = {COMPLEX TREATMENT OF COMPLICATED CRURAL DECOLLEMENT INJURY IN A DIABETIC PATIENT}, url = {https://m2.mtmt.hu/api/publication/2892375}, author = {Gárgyán, István and Csonka, Ákos and Boa, Kristóf and Varga, Endre}, journal-iso = {EUR J TRAUMA EMERG S}, journal = {EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY}, volume = {41}, unique-id = {2892375}, issn = {1863-9933}, year = {2015}, eissn = {1863-9941}, pages = {S182}, orcid-numbers = {Boa, Kristóf/0000-0002-6534-1434} } @article{MTMT:2892343, title = {ASSESSMENT OF OCCULT POSTERIOR PELVIC RING INJURIES IN ELDERLY PATIENTS}, url = {https://m2.mtmt.hu/api/publication/2892343}, author = {Gárgyán, István and Csonka, Ákos and Kószó, Balázs and Varga, Endre}, journal-iso = {EUR J TRAUMA EMERG S}, journal = {EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY}, volume = {41}, unique-id = {2892343}, issn = {1863-9933}, year = {2015}, eissn = {1863-9941}, pages = {S99} } @article{MTMT:2931622, title = {External cooling efficiently controls intraosseous temperature rise caused by drilling in a drilling guide system: an in vitro study}, url = {https://m2.mtmt.hu/api/publication/2931622}, author = {Boa, Kristóf and Endre, Varga Jr and Gabor, Pinter and Csonka, Ákos and Gárgyán, István and Varga, Endre}, doi = {10.1016/j.bjoms.2015.07.013}, journal-iso = {BRIT J ORAL MAX SURG}, journal = {BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY}, volume = {53}, unique-id = {2931622}, issn = {0266-4356}, year = {2015}, eissn = {1532-1940}, pages = {963-967}, orcid-numbers = {Boa, Kristóf/0000-0002-6534-1434} } @article{MTMT:2973115, title = {A Rare Class of New Dimeric Naphthoquinones from Diospyros lotus have Multidrug Reversal and Antiproliferative Effects}, url = {https://m2.mtmt.hu/api/publication/2973115}, author = {Rauf, A and Uddin, G and Siddiqui, BS and Molnár, József and Csonka, Ákos and Ahmad, B and Szabó, Diána and Farooq, U and Khan, A}, doi = {10.3389/fphar.2015.00293}, journal-iso = {FRONT PHARMACOL}, journal = {FRONTIERS IN PHARMACOLOGY}, volume = {16}, unique-id = {2973115}, year = {2015}, eissn = {1663-9812} } @misc{MTMT:2901849, title = {The anti-chlamydial effect of phenothiazines and disiloxane derivatives}, url = {https://m2.mtmt.hu/api/publication/2901849}, author = {Spengler, Gabriella and Mosolygó, Tímea and Molnár, József and Csonka, Andrea and Csonka, Ákos and Amaral, Leonard and Burián, Katalin}, unique-id = {2901849}, year = {2015}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Mosolygó, Tímea/0000-0002-4499-388X; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:2901785, title = {Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines.}, url = {https://m2.mtmt.hu/api/publication/2901785}, author = {Takács, Daniella and Csonka, Ákos and Horváth, Ádám and Windt, Tímea and Gajdács, Márió and Riedl, Zsuzsanna and Hajós, György and Amaral, L and Molnár, József and Spengler, Gabriella}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {35}, unique-id = {2901785}, issn = {0250-7005}, abstract = {BACKGROUND: The most common mechanism that reduces the efficacy of anticancer agents is overexpression of ATP-binding cassette (ABC) drug transporters. Phenothiazines and structurally-related compounds can sensitize multidrug-resistant (MDR) cells to chemotherapeutics. MATERIALS AND METHODS: Phenothiazine derivatives were investigated regarding their anticancer and MDR-reversing effect on colonic adenocarcinoma cells. The anti-proliferative and cytotoxic effects of the derivatives were assessed by the thiazolyl blue tetrazolium bromide (MTT) method, the modulation of the ABCB1 activity was measured by rhodamine 123 accumulation assay using flow cytometry. RESULTS: All phenothiazines exhibited potent cytotoxic effect on the sensitive and MDR colon adenocarcinoma cell lines. The inhibition of the ABCB1 transporter was greater in the presence of the phenothiazine derivatives than for the known ABCB1 inhibitor verapamil. CONCLUSION: It can be concluded that these derivatives show synergism in the presence of doxorubicin and could have potential as ABCB1 inhibitors.}, year = {2015}, eissn = {1791-7530}, pages = {3245-3251}, orcid-numbers = {Windt, Tímea/0000-0001-9913-3337; Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3063503, title = {NEW PERSPECTIVES IN THE TREATMENT OF CHLAMYDIA TRACHOMATIS INFECTIONS: PHENOTHIAZINES AND DISILOXANE DERIVATIVES AS POTENTIAL ANTI-CHLAMYDIAL AGENTS}, url = {https://m2.mtmt.hu/api/publication/3063503}, author = {Mosolygó, Tímea and MARION, SZATMÁRI and Molnár, József and Csonka, Andrea and Csonka, Ákos and LEONARD, AMARAL and Burián, Katalin and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {62}, unique-id = {3063503}, issn = {1217-8950}, year = {2015}, eissn = {1588-2640}, pages = {182-183}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Burián, Katalin/0000-0003-1300-2374; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2757032, title = {COMPARISON OF CYTOTOXICITY OF BUTYL-OXI-CARBONYL SUBSTITUTED STEROIDAL COMPOUNDS ON DIFFERENT CANCER CELL LINES IN VITRO}, url = {https://m2.mtmt.hu/api/publication/2757032}, author = {Csonka, Ákos and Spengler, Gabriella and Martins, Ana and Irén, Vincze and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {34}, unique-id = {2757032}, issn = {0250-7005}, year = {2014}, eissn = {1791-7530}, pages = {5870-5871}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:2756110, title = {Comparison of Cytotoxicity of Butyl-Oxi-Carbonyl substituted steroidal compounds on different cancer cell lines in vitro}, url = {https://m2.mtmt.hu/api/publication/2756110}, author = {Csonka, Ákos and Gabriella, Splenger and Ana, Martins and Irén, Vincze and Joseph, Molnar}, unique-id = {2756110}, year = {2014} } @misc{MTMT:2708436, title = {Tomportáji törést szenvedett betegek gyógyszerelésének jellemzői, és azok kórházi kimenetellel való összefüggéseinek vizsgálata}, url = {https://m2.mtmt.hu/api/publication/2708436}, author = {Bor, Andrea and Gyimesi, Nóra and Matuz, Mária and Doró, Géza and Csonka, Ákos and Gárgyán, István and Doró, Péter}, unique-id = {2708436}, year = {2014}, orcid-numbers = {Matuz, Mária/0000-0002-7877-2399; Doró, Péter/0000-0001-7784-6010} } @article{MTMT:2893802, title = {Szteroid vegyületek hatása tumor sejtvonalakon}, url = {https://m2.mtmt.hu/api/publication/2893802}, author = {Csonka, Ákos}, journal-iso = {LÉTÜNK (ÚJVIDÉK)}, journal = {LÉTÜNK (ÚJVIDÉK)}, volume = {4}, unique-id = {2893802}, issn = {0350-4158}, year = {2014}, pages = {66-72} } @article{MTMT:2785874, title = {Atípusos femurtörés}, url = {https://m2.mtmt.hu/api/publication/2785874}, author = {Csonka, Ákos and Gárgyán, István and Doró, Péter and Varga, Endre}, doi = {10.21755/MTO.2014.057.0203.005}, journal-iso = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, journal = {MAGYAR TRAUMATOLÓGIA ORTOPÉDIA KÉZSEBÉSZET PLASZTIKAI SEBÉSZET}, volume = {57}, unique-id = {2785874}, issn = {1217-3231}, year = {2014}, pages = {119-124}, orcid-numbers = {Doró, Péter/0000-0001-7784-6010} } @misc{MTMT:2732657, title = {Elnézett perilunaris ficam késői ellátása és tanulságai.}, url = {https://m2.mtmt.hu/api/publication/2732657}, author = {Csonka, Ákos and Simonka, János Aurél and Varga, Endre and Mácsai, Attila}, unique-id = {2732657}, year = {2014} } @misc{MTMT:2706664, title = {Hogy kerül az ileum a kenelbe?}, url = {https://m2.mtmt.hu/api/publication/2706664}, author = {Csonka, Ákos and Varga, Endre and Török, László and Mácsai, Attila and Ábrahám, Szabolcs and Deák, Gábor}, unique-id = {2706664}, year = {2014} } @misc{MTMT:2706656, title = {Csontpótló anyagok használata tibia plateau töréseknél}, url = {https://m2.mtmt.hu/api/publication/2706656}, author = {Csonka, Ákos and Gárgyán, István and Varga, Endre and Kószó, Balázs and Vági, Zsolt}, unique-id = {2706656}, year = {2014} } @misc{MTMT:2706655, title = {Időskori szeméremcsont törések okkult medencegyűrű sérülésének vizsgálata}, url = {https://m2.mtmt.hu/api/publication/2706655}, author = {Csonka, Ákos and Gárgyán, István and Varga, Endre and Kószó, Balázs and Vági, Zsolt and Sádt, Zoltán}, unique-id = {2706655}, year = {2014} } @misc{MTMT:2706652, title = {Atípusos femurtörések kezelése}, url = {https://m2.mtmt.hu/api/publication/2706652}, author = {Csonka, Ákos and Gárgyán, István and Varga, Endre and Sádt, Zoltán and Vági, Zsolt and Doró, Péter}, unique-id = {2706652}, year = {2014}, orcid-numbers = {Doró, Péter/0000-0001-7784-6010} } @misc{MTMT:2706648, title = {Klinikánk geriátriai programjának értékelése, a protetizált combnyaktörött betegek kapcsán}, url = {https://m2.mtmt.hu/api/publication/2706648}, author = {Csonka, Ákos and Faludi, László and Sádt, Zoltán and Gárgyán, István and Varga, Endre}, unique-id = {2706648}, year = {2014} } @misc{MTMT:2706636, title = {Beszámoló a klinikánkon bevezetett osteoporosis protokollról, ill. az eddig elért eredményekről}, url = {https://m2.mtmt.hu/api/publication/2706636}, author = {Csonka, Ákos and Bánki, László and Csonka, Endre and Varga, Endre and Gárgyán, István and Polyák, Ilona}, unique-id = {2706636}, year = {2014} } @CONFERENCE{MTMT:2526922, title = {Anticancer activity of thioridazine stereoisomers}, url = {https://m2.mtmt.hu/api/publication/2526922}, author = {Csonka, Ákos and Spengler, Gabriella and Martins, Ana and Ocsovszki, Imre and Chritsten, Jorn B and Hendricks, Oliver and Kristiansen, Jette E and Amaral, Leonard and Molnár, József}, booktitle = {ICACT 2014}, unique-id = {2526922}, year = {2014}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Ocsovszki, Imre/0000-0003-1290-996X} } @misc{MTMT:2591453, title = {Distalis femurtörések rögzítése LISS-DF lemezzel totál térdprotézis beültetése után}, url = {https://m2.mtmt.hu/api/publication/2591453}, author = {Gárgyán, István and Körmöndi, Sándor Pál and Csonka, Ákos and Vági, Zsolt and Varga, Endre}, unique-id = {2591453}, year = {2014} } @misc{MTMT:2732650, title = {Scaphoideum álízület kezelésének lehetőségei (irodalmi kitekintés, műtéti technika és 41 eset elemzése)}, url = {https://m2.mtmt.hu/api/publication/2732650}, author = {Simonka, János Aurél and Varga, Endre and Csonka, Ákos and Polyák, Ilona and Butt, Edina}, unique-id = {2732650}, year = {2014} } @article{MTMT:2470103, title = {Effect of thioridazine stereoisomers on the drug accumulation of mouse lymphoma and human prostate cancer cell lines in vitro.}, url = {https://m2.mtmt.hu/api/publication/2470103}, author = {Csonka, Ákos and Spengler, Gabriella and Martins, Ana and Ocsovszki, Imre and Christensen, JB and Hendricks, O and Kristiansen, JE and Amaral, L and Molnár, József}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {27}, unique-id = {2470103}, issn = {0258-851X}, abstract = {BACKGROUND: Cancer cells become refractory to chemotherapy as a consequence of their overexpression of multidrug transporters. MATERIALS AND METHODS: The anticancer and multidrug resistance (MDR) reversal effects of the racemic form and the two enantiomers of thoridazine were investigated on a mouse T-lymphoma cell line over-expressing the ATP-binding cassette, subfamily-B (MDR/TAP), member 1 (ABCB1) transporter (also known as P-glycoprotein) and on human PC3 prostate cancer cell line by 3-(4.5-dimethylthiazolyl-2)-2.5-diphenyl tetrazolium bromide (MTT) assay. The modulation of ABCB1 transporter activity was studied by rhodamine123 accumulation, the apoptosis-inducing effect was investigated using fluorescein isothiocyanate (FITC)-labeled annexin V and propidium iodide. RESULTS: The thioridazine racemic and (+) and (-) enantiomers were similarly effective. Drug accumulation by MDR mouse T-lymphoma cells was moderately modified in the presence of thioridazine derivatives. Thioridazine induced apoptosis of the MDR cancer cell line, but there was no significant apoptotic effect on the PC3 cell line. CONCLUSION: Apparently, the chirality of thioridazine has no importance in the inhibition of MDR phenotype of cancer cells.}, year = {2013}, eissn = {1791-7549}, pages = {815-820}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Ocsovszki, Imre/0000-0003-1290-996X} } @misc{MTMT:2571256, title = {Dynamic Locking Screw (DLS) alkalmazása elhúzódó humerus törésgyógyulás esetén}, url = {https://m2.mtmt.hu/api/publication/2571256}, author = {Gárgyán, István and Varga, Endre and Csonka, Ákos and Sádt, Zoltán and Vági, Zsolt}, unique-id = {2571256}, year = {2013} }