TY - JOUR AU - Szabó, Diána AU - Janovák, László AU - Abdelghafour, Mohamed M. AU - Takács, Tamás AU - Csanády, Miklós ifj. AU - Spengler, Gabriella AU - Szakács, László AU - Csanády, Miklós AU - Rovó, László TI - Új minimálinvazív kezelési lehetőségek jó- és rosszindulatú fül-orr-gégészeti betegségekben nanoszerkezetű hatóanyag-leadó rendszerek alkalmazásával = New minimally invasive treatment options in benign and malignant otorhinolaryngological diseases using nanostructured drug delivery systems JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 10 SP - 370 EP - 378 PG - 9 SN - 0030-6002 DO - 10.1556/650.2024.32978 UR - https://m2.mtmt.hu/api/publication/34729015 ID - 34729015 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Amin, Keristina AU - Abdelghafour, Mohamed M. AU - Varga, Viktória AU - Kiss, Tamás AU - Szabó, Diána AU - Rovó, László AU - Janovák, László TI - Mitomycin loaded self-assembled colloidal prodrug nanoparticles for magnetic drug targeting JF - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY J2 - J DRUG DELIV SCI TEC VL - 88 PY - 2023 PG - 11 SN - 1773-2247 DO - 10.1016/j.jddst.2023.104948 UR - https://m2.mtmt.hu/api/publication/34154074 ID - 34154074 LA - English DB - MTMT ER - TY - JOUR AU - Abdelghafour, Mohamed M. AU - Imre-Deák, Ágota AU - Kiss, Tamás AU - Budai-Szűcs, Mária AU - Katona, Gábor AU - Ambrus, Rita AU - Lőrinczi, Bálint AU - Keller-Pintér, Anikó AU - Szatmári, István AU - Szabó, Diána AU - Rovó, László AU - Janovák, László TI - Self-Assembling Injectable Hydrogel for Controlled Drug Delivery of Antimuscular Atrophy Drug Tilorone JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 12 PG - 23 SN - 1999-4923 DO - 10.3390/pharmaceutics14122723 UR - https://m2.mtmt.hu/api/publication/33293402 ID - 33293402 AB - A two-component injectable hydrogel was suitably prepared for the encapsulation and prolonged release of tilorone which is an antimuscular atrophy drug. The rapid (7–45 s, depending on the polymer concentration) in situ solidifications of the hydrogel were evoked by the evolving Schiff-base bonds between the aldehyde groups of modified PVA (4-formyl benzoate PVA, PVA-CHO, 5.9 mol% functionalization degree) and the amino groups of 3-mercaptopropionate chitosan (CHIT-SH). The successful modification of the initial polymers was confirmed by both FTIR and NMR measurements; moreover, a new peak appeared in the FTIR spectrum of the 10% w/v PVA-CHO/CHIT-SH hydrogel at 1647 cm−1, indicating the formation of a Schiff base (–CH=N–) and confirming the interaction between the NH2 groups of CHIT–SH and the CHO groups of PVA-CHO for the formation of the dynamic hydrogel. The reaction between the NH2 and CHO groups of the modified biopolymers resulted in a significant increase in the hydrogel’s viscosity which was more than one thousand times greater (9800 mPa·s) than that of the used polymer solutions, which have a viscosity of only 4.6 and 5.8 mPa·s, respectively. Furthermore, the initial chitosan was modified with mercaptopropionic acid (thiol content = 201.85 ± 12 µmol/g) to increase the mucoadhesive properties of the hydrogel. The thiolated chitosan showed a significant increase (~600 mN/mm) in adhesion to the pig intestinal membrane compared to the initial one (~300 mN/mm). The in vitro release of tilorone from the hydrogel was controlled with the crosslinking density/concentration of the hydrogel; the 10% w/v PVA-CHO/CHIT-SH hydrogel had the slowest releasing (21.7 h−1/2) rate, while the 2% w/v PVA-CHO/CHIT-SH hydrogel had the fastest releasing rate (34.6 h−1/2). Due to the characteristics of these hydrogels, their future uses include tissue regeneration scaffolds, wound dressings for skin injuries, and injectable or in situ forming drug delivery systems. Eventually, we hope that the developed hydrogel will be useful in the local treatment of muscle atrophy, such as laryngotracheal atrophy. LA - English DB - MTMT ER - TY - JOUR AU - Abdelghafour, Mohamed M. AU - Imre-Deák, Ágota AU - Szabó, Diána AU - Dékány, Imre AU - Rovó, László AU - Janovák, László TI - Use of Self-Assembled Colloidal Prodrug Nanoparticles for Controlled Drug Delivery of Anticancer, Antifibrotic and Antibacterial Mitomycin JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 12 PG - 14 SN - 1661-6596 DO - 10.3390/ijms23126807 UR - https://m2.mtmt.hu/api/publication/32893726 ID - 32893726 LA - English DB - MTMT ER - TY - JOUR AU - Igaz, Nóra AU - Bélteky, Péter AU - Kovács, Dávid AU - Papp, Csaba Gergő AU - Rónavári, Andrea AU - Szabó, Diána AU - Gácser, Attila AU - Kónya, Zoltán AU - Csontné Kiricsi, Mónika TI - Functionalized Mesoporous Silica Nanoparticles for Drug-Delivery to Multidrug-Resistant Cancer Cells JF - INTERNATIONAL JOURNAL OF NANOMEDICINE J2 - INT J NANOMED VL - 17 PY - 2022 SP - 3079 EP - 3096 PG - 18 SN - 1176-9114 DO - 10.2147/IJN.S363952 UR - https://m2.mtmt.hu/api/publication/33003489 ID - 33003489 N1 - Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, Hungary Department of Applied and Environmental Chemistry, University of Szeged, Szeged, Hungary Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, Inserm, CNRS, Valbonne, France HCEMM-USZ Fungal Pathogens Research Group, Department of Microbiology, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head & Neck Surgery, Szeged, Hungary Eötvös Loránd Research Network, Reaction Kinetics and Surface Chemistry Research Group, Szeged, Hungary Cited By :8 Export Date: 27 February 2024 Correspondence Address: Kónya, Z.; Department of Applied and Environmental Chemistry, Rerrich square 1, Hungary; email: konya@chem.u-szeged.hu Correspondence Address: Kiricsi, M.; Department of Biochemistry and Molecular Biology, Közép fasor 52, Hungary; email: kiricsim@bio.u-szeged.hu AB - Background: Multidrug resistance is a common reason behind the failure of chemotherapy. Even if the therapy is effective, serious adverse effects might develop due to the low specificity and selectivity of antineoplastic agents. Mesoporous silica nanoparticles (MSNs) are promising materials for tumor-targeting and drug-delivery due to their small size, relatively inert nature, and extremely large specific surfaces that can be functionalized by therapeutic and targeting entities. We aimed to create a fluorescently labeled MSN-based drug-delivery system and investigate their internalization and drug-releasing capability in drug-sensitive MCF-7 and P-glycoprotein-overexpressing multidrug-resistant MCF-7 KCR cancer cells.Methods and Results: To track the uptake and subcellular distribution of MSNs, particles with covalently coupled red fluorescent Rhodamine B (RhoB) were produced (RhoB@MSNs). Both MCF-7 and MCF-7 KCR cells accumulated a significant amount of RhoB@MSNs. The intracellular RhoB@MSN concentrations did not differ between sensitive and multidrug-resistant cells and were kept at the same level even after cessation of RhoB@MSN exposure. Although most RhoB@MSNs resided in the cytoplasm, significantly more RhoB@MSNs co-localized with lysosomes in multidrug-resistant cells compared to sensitive counterparts. To examine the drug-delivery capability of these particles, RhoB@Rho123@MSNs were established, where RhoB-functionalized nanoparticles carried green fluorescent Rhodamine 123 (Rho123) -a P-glycoprotein substrate - as cargo within mesopores. Significantly higher Rho123 fluorescence intensity was detected in RhoB@Rho123@MSN-treated multidrug-resistant cells than in free Rho123-exposed counterparts. The exceptional drug-delivery potential of MSNs was further verified using Mitomycin C (MMC)-loaded RhoB@MSNs (RhoB@MMC@MSNs). Exposures to RhoB@MMC@MSNs significantly decreased the viability not only of drug-sensitive but of multidrug-resistant cells and the elimination of MDR cells was significantly more robust than upon free MMC treatments.Conclusion: The efficient delivery of Rho123 and MMC to multidrug-resistant cells via MSNs, the amplified and presumably prolonged intracellular drug concentration, and the consequently enhanced cytotoxic effects envision the enormous potential of MSNs to defeat multidrug-resistant cancer. LA - English DB - MTMT ER - TY - JOUR AU - ABDUR, RAUF AU - SAUD, BAWAZEER AU - MUSLIM, RAZA AU - EMAN, EL-SHARKAWY AU - MD., HABIBUR RAHMAN AU - MOHAMED, A. EL-ESAWI AU - GHIAS, UDDIN AU - BINA, S. SIDDIQUI AU - ANEES, AHMED KHALIL AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána AU - HAROON, KHAN AU - MOHAMMAD, S. MUBARAK AU - TAIBI, BEN HADDA AU - MUDYAWATI, KAMARUDDIN AU - SEEMA, PATEL TI - Reversal of multidrug resistance and antitumor promoting activity of 3-oxo-6β-hydroxy- β-amyrin isolated from Pistacia integerrima JF - BIOCELL J2 - BIOCELL VL - 45 PY - 2021 IS - 1 SP - 139 EP - 147 PG - 9 SN - 0327-9545 DO - 10.32604/biocell.2021.013277 UR - https://m2.mtmt.hu/api/publication/31794441 ID - 31794441 N1 - Export Date: 15 January 2022 CODEN: BOCEE Correspondence Address: BAWAZEER, S.; Department of Pharmaceutical Chemistry, Saudi Arabia; email: ssbawazeer@uqu.edu.sa Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; curcumin, 458-37-7; rhodamine 123, 62669-70-9; verapamil, 152-11-4, 52-53-9 LA - English DB - MTMT ER - TY - JOUR AU - Bawazeer, Sami AU - Rauf, Abdur AU - Mabkhot, Yahia N. AU - Al-Showiman, Salim S. AU - Patel, Seema AU - Gul, Somia AU - Raza, Muslim AU - Molnár, József AU - Szabó, Diána AU - Csonka, Ákos AU - Mujeeb-ur-, Rehman AU - Mubarak, Mohammad S. AU - Zengin, Gokhan AU - Ramadan, Mohamed Fawzy TI - Isolation of Bioactive Compounds from Pistacia integerrima with Promising Effects on Reverse Cancer Multidrug Resistance JF - RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY J2 - RUSS J BIOORG CHEM+ VL - 47 PY - 2021 IS - 5 SP - 997 EP - 1003 PG - 7 SN - 1068-1620 DO - 10.1134/S1068162021050204 UR - https://m2.mtmt.hu/api/publication/32470529 ID - 32470529 N1 - ACKNOWLEDGMENTS: The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through Research group Project under grant number (R.G.P. 2/26/42). LA - English DB - MTMT ER - TY - PAT AU - Janovák, László AU - Rovó, László AU - Szabó, Diána AU - Dékány, Imre AU - Abdelghafour, Mohamed M. TI - SELF-ASSEMBLED MUCOADHESIVE BIOPOLYMER PARTICLE RELEASE SYSTEM AND PREPARATION METHOD THEREOF CY - Country:10001(1) PY - 2021 UR - https://m2.mtmt.hu/api/publication/32658681 ID - 32658681 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Takács, Tamás AU - Abdelghafour, Mohamed M. AU - Imre-Deák, Ágota AU - Szabó, Diána AU - Sebők, Dániel AU - Dékány, Imre AU - Rovó, László AU - Kukovecz, Ákos AU - Janovák, László TI - Surface wetting driven release of antifibrotic Mitomycin-C drug from modified biopolymer thin films JF - EUROPEAN POLYMER JOURNAL J2 - EUR POLYM J VL - 139 PY - 2020 PG - 10 SN - 0014-3057 DO - 10.1016/j.eurpolymj.2020.109995 UR - https://m2.mtmt.hu/api/publication/31604537 ID - 31604537 N1 - University of Szeged, Interdisciplinary Excellence Centre, Department of Physical Chemistry and Materials Science, H-6720, Rerrich Béla tér 1, Szeged, Hungary University of Szeged, Interdisciplinary Excellence Centre, Department of Applied and Environmental Chemistry, H-6720, Rerrich Béla tér 1, Szeged, Hungary Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt Department of Oto-Rhino-Laryngology and Head & Neck Surgery, University of Szeged, H-6724, Tisza Lajos krt. 111, Szeged, Hungary Cited By :2 Export Date: 19 June 2023 CODEN: EUPJA Correspondence Address: Kukovecz, Á.; University of Szeged, H-6720, Rerrich Béla tér 1, Hungary; email: kakos@chem.u-szeged.hu Funding details: Hungarian Scientific Research Fund, OTKA, GINOP-2.3.2-15-2016-00013, K 132446 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT, INT/HUN/P-18/2017 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, 2017- 2.3.7-TÉT-IN-2017-00008, GINOP-2.3.3-15-2016-00010 Funding details: Innovációs és Technológiai Minisztérium Funding text 1: The authors are very thankful for the financial support from the Hungarian Scientific Research Fund (OTKA) K 132446 and for the financial support from the project named GINOP-2.3.2-15-2016-00013 . This paper was also supported by the UNKP-20-5 New National Excellence Program of the Ministry For Innovation and Technology and by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . The Ministry of Human Capacities , Hungary grant 20391-3/2018/FEKUSTRAT is also acknowledged. Á.K. acknowledges support from the Indo-Hungarian Joint Research project no. INT/HUN/P-18/2017 ( NKFIH 2017- 2.3.7-TÉT-IN-2017-00008 ). Financial support for purchasing the CT instrument was provided by the Hungarian National Research, Development and Innovation Office through project GINOP-2.3.3-15-2016-00010. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Csanády, Miklós AU - Rovó, László TI - Hemipharyngo-Laryngectomy for Treatment of T1-2 Hypopharyngeal Tumours JF - American Journal of Otolaryngology and Head and Neck Surgery J2 - Am J Otolaryngol Head Neck Surg VL - 2 PY - 2019 IS - 5 PG - 5 SN - 2640-6640 UR - https://m2.mtmt.hu/api/publication/30758940 ID - 30758940 LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Kovács, Dávid AU - Endrész, Valéria AU - Igaz, Nóra AU - Jenovai, Kitti AU - Spengler, Gabriella AU - Tiszlavicz, László AU - Molnár, József AU - Burián, Katalin AU - Csontné Kiricsi, Mónika AU - Rovó, László TI - Antifibrotic effect of mitomycin-C on human vocal cord fibroblasts JF - LARYNGOSCOPE J2 - LARYNGOSCOPE VL - 129 PY - 2019 IS - 7 SP - E255 EP - E262 PG - 8 SN - 0023-852X DO - 10.1002/lary.27657 UR - https://m2.mtmt.hu/api/publication/30405220 ID - 30405220 N1 - GINOP-2.3.2-15-2016-00040 Department of Oto-Rhino-Laryngology and Head & Neck Surgery, Szeged, Hungary Department of Medical Microbiology and Immunobiology, Szeged, Hungary Department of Pathology, Faculty of Medicine, Szeged, Hungary Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Cited By :2 Export Date: 4 September 2020 CODEN: LARYA Correspondence Address: Szabó, D.; Department of Oto-Rhino-Laryngology and Head & Neck SurgeryHungary; email: diniklinik@freemail.hu Chemicals/CAS: mitomycin, 1404-00-8, 50-07-7, 74349-48-7; ACTA2 protein, human; Actins; Mitomycin; Transforming Growth Factor beta Funding details: GINOP-2.3.2-15-2016-00040 Funding text 1: This study received support from the National Research, Development and Innovation Office-NKFIH (GINOP-2.3.2-15-2016-00040). LA - English DB - MTMT ER - TY - JOUR AU - Vass, Gábor AU - Bere, Zsófia AU - Szabó, Diána AU - Rovó, László TI - A középarc lágy részeinek nasolabialis függesztése: új, minimálinvazív és reverzibilis módszer az arc statikus szimmetrizálására végleges arcidegbénulásban [Nasolabial suspension of the malar fat pad: a new, minimally invasive and reversible technique for facial symmetrization in permanent facial paralysis] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 160 PY - 2019 IS - 22 SP - 869 EP - 872 PG - 4 SN - 0030-6002 DO - 10.1556/650.2019.31344 UR - https://m2.mtmt.hu/api/publication/30758937 ID - 30758937 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Cyboran-Mikolajczyk, S AU - Csonka, Ákos AU - Molnár, József AU - Szabó, Diána AU - Oszmianski, J AU - Kleszczynska, H TI - In Vitro Studies of Anti-Hemolytic and Cytotoxic Activity of Procyanidin-Rich Extract from the Leaves of Actinidia arguta JF - POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES J2 - POLISH J FOOD NUTR SCI VL - 68 PY - 2018 IS - 2 SP - 171 EP - 177 PG - 7 SN - 1230-0322 DO - 10.1515/pjfns-2017-0021 UR - https://m2.mtmt.hu/api/publication/3341125 ID - 3341125 N1 - This work was supported from funds of the statutory activities of the Department of Physics and Biophysics, Wroclaw University of Environmental and Life Sciences. The study was also supported by Szeged Foundation for Cancer Research, by the project TAMOP-4.2.2A- 11/1/KONV-2012- 0035 LA - English DB - MTMT ER - TY - JOUR AU - Rauf, A AU - Shaheen, U AU - Raza, M AU - Uddin, G AU - Hadda, TB AU - Mabkhot, YN AU - Jehan, N AU - Ahmad, B AU - Raza, S AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána TI - Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus JF - PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - PAK J PHARM SCI VL - 31 PY - 2018 IS - 3 SP - 821 EP - 825 PG - 5 SN - 1011-601X UR - https://m2.mtmt.hu/api/publication/3370144 ID - 3370144 N1 - Funding Agency and Grant Number: Higher Education Commission of PakistanHigher Education Commission of Pakistan [21:619/SRGP/RD/HEC/2014]; Deanship of Scientific at King Saud University [RG-1437-29] Funding text: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29). Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, East Road of North Third RingChao Yang Dist., Beijing, China Institute of Chemical Sciences, University of Peshawar, K.P.K Peshawar, Pakistan LCM Laboratory, University of Mohamed 1st, Faculty of Sciences, Oujda, Morocco Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia Department of Geology, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Export Date: 31 July 2020 Correspondence Address: Shaheen, U.; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura UniversitySaudi Arabia; email: usamayousef2003@yahoo.com Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; chloroform, 67-66-3; Naphthoquinones; Plant Extracts Funding details: Higher Education Commision, Pakistan, HEC, 21:619/SRGP/R&D/HEC/2014 Funding text 1: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29). Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, East Road of North Third RingChao Yang Dist., Beijing, China Institute of Chemical Sciences, University of Peshawar, K.P.K Peshawar, Pakistan LCM Laboratory, University of Mohamed 1st, Faculty of Sciences, Oujda, Morocco Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia Department of Geology, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Cited By :1 Export Date: 18 January 2021 Correspondence Address: Shaheen, U.; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura UniversitySaudi Arabia; email: usamayousef2003@yahoo.com Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; chloroform, 67-66-3; Naphthoquinones; Plant Extracts Funding details: Higher Education Commision, Pakistan, HEC, 21:619/SRGP/R&D/HEC/2014 Funding text 1: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29). AB - A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Kovács, Dávid AU - Endrész, Valéria AU - Igaz, Nóra AU - Spengler, Gabriella AU - Csontné Kiricsi, Mónika AU - Tiszlavicz, László AU - Rovó, László TI - Mitomycin-C fibrosisgátló hatása humán primer hangszalag-fibrolastokon - felső légúti hegesedések kezelésének új lehetősége JF - FÜL-ORR-GÉGEGYÓGYÁSZAT J2 - FÜL-ORR-GÉGEGYÓGYÁSZAT VL - 64 PY - 2018 IS - 3 SP - 110 EP - 110 PG - 1 SN - 0016-237X UR - https://m2.mtmt.hu/api/publication/31402136 ID - 31402136 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bashir, Ahmad AU - Muhammad, Rizwan AU - Abdur, Rauf AU - Muslim, Raza AU - Shumaila, Bashir AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána AU - Mohammad, S Mubarak AU - Mah, Noor AU - Bina, S Siddiqui TI - Isolation of Chlorogenic Acid from Soil Borne Fungi Screlotium rolfsii, their Reversal of Multidrug Resistance and anti-proliferative in Mouse Lymphoma cells JF - MEDICINAL CHEMISTRY J2 - MED CHEM VL - 13 PY - 2017 IS - 8 SP - 721 EP - 726 PG - 6 SN - 1573-4064 DO - 10.2174/1573406413666170612110443 UR - https://m2.mtmt.hu/api/publication/3240653 ID - 3240653 N1 - Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, KPK-25120, Pakistan Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, 23561, Pakistan State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, No. 15 East Road of North Third Ring, Chao Yang District, Beijing, 100029, China Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza L. krt. 111, Szeged, H-6725, Hungary Department of Chemistry, University of Jordan, Amman, 11942, Jordan H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan Cited By :3 Export Date: 31 July 2020 CODEN: MCEHA Correspondence Address: Rauf, A.; Department of Chemistry, University of SwabiPakistan; email: mashaljcs@yahoo.com Chemicals/CAS: chlorogenic acid, 327-97-9; multidrug resistance protein, 149200-37-3, 208997-77-7; verapamil, 152-11-4, 52-53-9; Antineoplastic Agents, Phytogenic; Chlorogenic Acid Funding Agency and Grant Number: Higher Education Commission of PakistanHigher Education Commission of Pakistan [21:619/SRGP/RD/HEC/2014] Funding text: The authors are grateful for the financial support provided by Higher Education Commission of Pakistan for award of research start up grant No (21:619/SRGP/R&D/HEC/2014. Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, KPK-25120, Pakistan Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, 23561, Pakistan State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, No. 15 East Road of North Third Ring, Chao Yang District, Beijing, 100029, China Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Department of Oto-Rhino-Laryngology and Head and Neck Surgery, Faculty of Medicine, University of Szeged, Tisza L. krt. 111, Szeged, H-6725, Hungary Department of Chemistry, University of Jordan, Amman, 11942, Jordan H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan Cited By :5 Export Date: 18 January 2021 CODEN: MCEHA Correspondence Address: Rauf, A.; Department of Chemistry, University of SwabiPakistan; email: mashaljcs@yahoo.com Chemicals/CAS: chlorogenic acid, 327-97-9; multidrug resistance protein, 149200-37-3, 208997-77-7; verapamil, 152-11-4, 52-53-9; Antineoplastic Agents, Phytogenic; Chlorogenic Acid AB - BACKGROUND: Fungi performing a wide range of function in soil by secreting low molecular weight compound known as secondary metabolites. S. rolfsii is a soil borne phytopathogenic fungi was used for the production of bioactive compounds. OBJECTIVE: The present study belongs to evaluate the anticancer potentials of a secondary metabolites isolated from S. rolfsii, their multidrug resistance (MDR), and molecular docking study. METHOD: (1S,3R,4R,5R,E)-3-(3-(3,4-Dihydroxyphenyl)acryloyloxy)-1,4,5 trihydroxycyclohexanecarboxylic acid (1), or best known as chlorogenic acid, was isolated from the ethyl acetate fraction of crude secondary metabolites produced by the soil borne Fungus Screlotium rolfsii. Structure of chlorogenic acid (1) was confirmed by means of FT-IR, 1H NMR, 13C NMR, and mass spectrometry as well as by melting point. RESULTS: Effect of compound 1 on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) against cancer cells was evaluated with a rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma. Compound 1 was also evaluated for Anti-proliferative effect on the L5178 mouse T-cell lymphoma cell line. CONCLUSION: Results from the present investigation revealed that compound 1 exhibits excellent MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Compound 1 also showed anti-proliferative effect on L5178Y mouse T-lymphoma cell line. LA - English DB - MTMT ER - TY - GEN AU - Szabó, Diána AU - Endrész, Valéria AU - Dávid, Kovács AU - Igaz, Nóra AU - Spengler, Gabriella AU - Molnár, József AU - Burián, Katalin AU - Csontné Kiricsi, Mónika AU - Rovó, László TI - 4th Congress of European ORL- HNS. Antifibrotic effect of Mitomycin-C human vocal cord fibroblast - impact on upper airway stenosis treatment TS - Antifibrotic effect of Mitomycin-C human vocal cord fibroblast - impact on upper airway stenosis treatment PY - 2017 SP - 110 EP - 110 PG - 1 UR - https://m2.mtmt.hu/api/publication/3341246 ID - 3341246 N1 - (absztrakt) LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Bella, Zsolt TI - Intranasalis szteroidterápia alkalmazása gyermekkori felső légúti betegségekben JF - GYERMEKORVOS TOVÁBBKÉPZÉS J2 - GYERMEKORVOS TOVÁBBKÉPZÉS VL - 16 PY - 2017 IS - 2 SP - 81 EP - 83 PG - 3 SN - 1589-0309 UR - https://m2.mtmt.hu/api/publication/3241401 ID - 3241401 N1 - Kapcsolódó rekord: 3241061 (csonkap 2020.05.21.) LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Bella, Zsolt TI - Intranasalis szteroid terápia alkalmazása gyermekkori felső légúti betegségekben JF - GYERMEKGYÓGYÁSZATI TOVÁBBKÉPZŐ SZEMLE J2 - GYERMEKGYÓGYÁSZATI TOVÁBBKÉPZŐ SZEMLE VL - 22 PY - 2017 IS - 2 SP - 103 EP - 104 PG - 2 SN - 1585-4396 UR - https://m2.mtmt.hu/api/publication/3241061 ID - 3241061 N1 - Kapcsolódó rekord: 3241401 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ahmad, B AU - Rizwan, M AU - Rauf, A AU - Raza, M AU - Azam, S AU - Bashir, S AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána TI - Isolation and Structure Elucidation, Molecular Docking Studies of Screlotiumol from Soil Borne Fungi Screlotium rolfsii and their Reversal of Multidrug Resistance in Mouse Lymphoma Cells JF - ASIAN PACIFIC JOURNAL OF CANCER PREVENTION J2 - ASIAN PAC J CANCER P VL - 17 PY - 2016 IS - 4 SP - 2083 EP - 2087 PG - 5 SN - 1513-7368 DO - 10.7314/APJCP.2016.17.4.2083 UR - https://m2.mtmt.hu/api/publication/3073568 ID - 3073568 N1 - Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, Pakistan Department of Geology, University of Swabi, Ambar, Khyber Pakhtunkhwa, Pakistan State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China Department of Pharmacy, University of Peshawar, Peshawar, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Cited By :4 Export Date: 31 July 2020 Correspondence Address: Rauf, A.; Department of Geology, University of SwabiPakistan; email: mashaljcs@yahoo.com Chemicals/CAS: acetic acid ethyl ester, 141-78-6; multidrug resistance protein, 149200-37-3, 208997-77-7; ABCB1 protein, human; Acetates; Antineoplastic Agents; Benzopyrans; ethyl acetate; P-Glycoproteins; Plant Extracts; screlotiumol Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, Pakistan Department of Geology, University of Swabi, Ambar, Khyber Pakhtunkhwa, Pakistan State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, China Department of Pharmacy, University of Peshawar, Peshawar, Pakistan Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary Cited By :4 Export Date: 18 January 2021 Correspondence Address: Rauf, A.; Department of Geology, University of SwabiPakistan; email: mashaljcs@yahoo.com Chemicals/CAS: acetic acid ethyl ester, 141-78-6; multidrug resistance protein, 149200-37-3, 208997-77-7; ABCB1 protein, human; Acetates; Antineoplastic Agents; Benzopyrans; ethyl acetate; P-Glycoproteins; Plant Extracts; screlotiumol AB - A new compound namely (13-(3,3-dihydroxypropyl)-1,6-dihydroxy-3,4-dihydro-1H-isochromen-8(5H)-one (1) was isolated from an ethyl acetate extract of the borne fungi Screlotium rolfsii. Its chemical structure was elucidated by spectroscopic analysis. Screlotiumol 1 were evaluated for their effects on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) of the soil borne fungi. The multidrug resistant P-glycoprotein is a target for chemotherapeutic drugs in cancer cells. In the present study rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma which showed excellent MDR reversing effect in a dose dependent manner against mouse T-lymphoma cell line. Moreover, molecular docking studies of compound-1 also showed better results as compared with the standard. Therefore the preliminary results obtained from this study suggest that screlotiumol 1 could be used as a potential agent for the treatment of cancer. LA - English DB - MTMT ER - TY - JOUR AU - Rauf, A AU - Uddin, G AU - Raza, M AU - Ahmad, A AU - Jehan, N AU - Ahmad, B AU - Nisar, M AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána AU - Khan, A AU - Farooq, U AU - Noor, M TI - Reversal of Multidrug Resistance and Computational Studies of Pistagremic Acid Isolated from Pistacia integerrima. JF - ASIAN PACIFIC JOURNAL OF CANCER PREVENTION J2 - ASIAN PAC J CANCER P VL - 17 PY - 2016 IS - 4 SP - 2311 EP - 2314 PG - 4 SN - 1513-7368 DO - 10.7314/APJCP.2016.17.4.2311 UR - https://m2.mtmt.hu/api/publication/3073567 ID - 3073567 AB - Pistagremic acid (PA) is a bioactive triterpenoid isolated from various parts of Pistacia integerrima plants. The aim of this research was to investigate PA for reversion of multidrug resistant (MDR) mediated by P-glycoprotein using rhodamine-123 exclusion study on a multidrug resistant human ABCB1 (ATP-binding cassette, sub-family B, member 1) gene-transfected mouse T-lymphoma cell line in vitro. Results were similar to those with verapamil as a positive control. Docking studies of PA and standard Rhodamine123 were carried out against a P-gp crystal structure which showed satisfactory results. Actually, PA cannot bind exactly where co-crystallized ligand of P-gp is already present. However, the docking study predicted that if a compound gives a lesser score then it may have some potency. The docking scores of PA and Rhodamine were similar. Therefore, we can conclude that there are certain important chemical features of PA which are responsible for the inhibiting potency of P-gp. LA - English DB - MTMT ER - TY - JOUR AU - Rauf, A AU - Uddin, G AU - Raza, M AU - Ahmad, B AU - Jehan, N AU - Siddiqui, BS AU - Molnár, József AU - Csonka, Ákos AU - Szabó, Diána TI - Reversal of Multidrug Resistance in Mouse Lymphoma Cells by Extracts and Flavonoids from Pistacia integerrima JF - ASIAN PACIFIC JOURNAL OF CANCER PREVENTION J2 - ASIAN PAC J CANCER P VL - 17 PY - 2016 IS - 1 SP - 51 EP - 55 PG - 5 SN - 1513-7368 DO - 10.7314/APJCP.2016.17.1.51 UR - https://m2.mtmt.hu/api/publication/3013412 ID - 3013412 AB - Phytochemical investigation of Pistacia integerrima has highlighted isolation of two known compounds naringenin (1) and dihydrokaempferol (2). A crude extract and these isolated compounds were here evaluated for their effects on reversion of multidrug resistance (MDR) mediated by P-glycoprotein (P-gp). The multidrug resistance P-glycoprotein is a target for chemotherapeutic drugs from cancer cells. In the present study rhodamine- 123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma cells showed excellent MDR reversing effects in a dose dependent manner. In-silico molecular docking investigations demonstrated a common binding site for Rhodamine123, and compounds naringenin and dihydrokaempferol. Our results showed that the relative docking energies estimated by docking softwares were in satisfactory correlation with the experimental activities. Preliminary interaction profile of P-gp docked complexes were also analysed in order to understand the nature of binding modes of these compounds. Our computational investigation suggested that the compounds interactions with the hydrophobic pocket of P-gp are mainly related to the inhibitory activity. Moreover this study s a platform for the discovery of novel natural compounds from herbal origin, as inhibitor molecules against the P-glycoprotein for the treatment of cancer. LA - English DB - MTMT ER - TY - JOUR AU - Rauf, A AU - Uddin, G AU - Siddiqui, BS AU - Molnár, József AU - Csonka, Ákos AU - Ahmad, B AU - Szabó, Diána AU - Farooq, U AU - Khan, A TI - A Rare Class of New Dimeric Naphthoquinones from Diospyros lotus have Multidrug Reversal and Antiproliferative Effects JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 16 PY - 2015 IS - 6 PG - 9 SN - 1663-9812 DO - 10.3389/fphar.2015.00293 UR - https://m2.mtmt.hu/api/publication/2973115 ID - 2973115 LA - English DB - MTMT ER - TY - JOUR AU - Bach, Ádám AU - Bella, Zsolt AU - Sztanó, Balázs AU - Vass, Gábor AU - Szakács, László AU - Szabó, Diána AU - Jóri, József AU - Rovó, László TI - A microdebriderrel végzett intracapsularis shaver tonsillectomia és a hagyományos extracapsularis tonsillectomia összehasonlítása a posztoperatív fájdalom és a sebgyógyulás tekintetében JF - FÜL-ORR-GÉGEGYÓGYÁSZAT J2 - FÜL-ORR-GÉGEGYÓGYÁSZAT VL - 60 PY - 2014 IS - 2 SP - 54 EP - 57 PG - 4 SN - 0016-237X UR - https://m2.mtmt.hu/api/publication/2839173 ID - 2839173 AB - A szerzők randomizált, prospektív, kettős vak vizsgálatuk során összehasonlították az intracapsularis shaver tonsillectomiát és a hagyományos extracapsularis tonsillectomiát a posztoperatív fájdalom és a sebgyógyulási zavarok tekintetében. A szakirodalomban is egyedülálló módon, a betegek jobb és bal oldali tonsilláját különböző módszerrel távolították el, ezzel kiküszöbölve az egyénenként igen eltérő fájdalomtolerancia és sebgyógyulási különbségek vizsgálati eredményeket torzító hatásait. A két műtéti technika között szignifikáns különbség sem a posztoperatív fájdalom, sem a sebgyógyulás vizsgált paramétereinek tekintetében nem volt kimutatható. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Spengler, Gabriella AU - Molnár, József AU - Gábor, Tax AU - Kornélia, Szabó AU - Rovó, László TI - Analysis of the interaction of normal human fibroblasts and different cancer cells in mixed cultures by xcelligence studies JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 34 PY - 2014 IS - 10 SP - 6197 EP - 6197 PG - 1 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2757043 ID - 2757043 LA - English DB - MTMT ER - TY - CONF AU - Szabó, Diána AU - Molnár, József AU - Janovák, László AU - Dékány, Imre AU - Rovó, László TI - A laryngo-trachealis szűkületek nanotechnológiai módszereket felhasználó minimál invazív kezelése T2 - Magyar Fül-orr-gége és Fej-nyaksebész Orvosok Egyesülete 43.kongresszusa PY - 2014 UR - https://m2.mtmt.hu/api/publication/2834232 ID - 2834232 LA - Hungarian DB - MTMT ER - TY - CONF AU - Szabó, Diána AU - Rovó, László AU - Bere, Zsófia AU - Molnár, József AU - Janovák, László AU - Imre, Dékány TI - Topical and delayed usage of Mitomycin-C for the treatment of laryngotracheal stenosis T2 - 2nd Meeting of European Academy of ORL-HNS and CE ORL-HNS otorhinolaryngology & head and neck surgery PY - 2013 UR - https://m2.mtmt.hu/api/publication/2574614 ID - 2574614 LA - English DB - MTMT ER - TY - GEN AU - Szabó, Diána AU - Csanády, Miklós AU - Molnár, József AU - Janovák, László AU - Dékány, Imre AU - Rovó, László TI - Nanotechnológia lehetőségei az endoscopos gégesebészetben PY - 2012 UR - https://m2.mtmt.hu/api/publication/2516319 ID - 2516319 LA - Hungarian DB - MTMT ER - TY - CONF AU - Csanády, M AU - Sztanó, B AU - Szabó, Diána AU - Czinger, J AU - Jóri, J TI - Supracricoide Hemipharyngo-Laryngektomie der T1, T2 Tumoren des Sinus Piriformis T2 - 80. Deutscher HNO Kongress PY - 2009 UR - https://m2.mtmt.hu/api/publication/2516295 ID - 2516295 LA - German DB - MTMT ER - TY - CONF AU - Szabó, Diána AU - Csanády, M AU - Sztanó, B AU - Czigner, J AU - Jóri, J TI - Supracricoid hemipharyngo-laryngectomy for treatment of T1-2 hypopharyngeal tumors T2 - 79. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V PY - 2008 UR - https://m2.mtmt.hu/api/publication/2574629 ID - 2574629 LA - English DB - MTMT ER - TY - CONF AU - Szabó, Diána AU - Rovó, László AU - Németh, I AU - Jóri, J TI - Juvenilis gégepapilloma T2 - Magyar Gyermek Fül-, Orr-, Gégeorvosok 17. Kongresszusa PY - 2007 UR - https://m2.mtmt.hu/api/publication/2516277 ID - 2516277 LA - Hungarian DB - MTMT ER - TY - CONF AU - Rovó, László AU - Szabó, Diána TI - A gastroesophagealis refluxbetegség aktuális fül-orr-gégészeti irodalma T2 - A Magyar Fül-, Orr-, Gégeszakorvosok Egyesülete PY - 2006 UR - https://m2.mtmt.hu/api/publication/2516262 ID - 2516262 LA - Hungarian DB - MTMT ER - TY - CONF AU - Szabó, Diána AU - Rovó, László TI - Botulinus toxin okozta kétoldali hangszalag bénulás ritka esete T2 - A Magyar Fül-, Orr-, Gégeszakorvosok Egyesülete PY - 2006 SP - x UR - https://m2.mtmt.hu/api/publication/2516236 ID - 2516236 LA - Hungarian DB - MTMT ER - TY - CONF AU - Szabó, Diána AU - Czigner, J ED - Hungarian, Onkology TI - Agyideg bénulások hátterében álló nasopharyngealis tumor. irodalmi áttekintés egy eset kapcsán TS - irodalmi áttekintés egy eset kapcsán T2 - A Magyar Onkológusok Társaságának XXVI. Kongesszusa PY - 2005 SP - ˘" UR - https://m2.mtmt.hu/api/publication/2516205 ID - 2516205 LA - Hungarian DB - MTMT ER - TY - CONF AU - Szabó, Diána AU - Czigner, J AU - Csanády, M AU - Gires, O AU - Lang, S AU - Kastenbauer, E TI - Specifikus COX-2 gátló vegyületek hatása a monocyták migrációjára és adhéziójára T2 - A Magyar Fül-, Orr-, Gégeszakorvosok Egyesülete C1 - Siófok PY - 2002 SP - "˘" UR - https://m2.mtmt.hu/api/publication/2515719 ID - 2515719 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Adalbert, Lívia AU - Szabó, Diána AU - Petri, IB AU - Shoyama, Y AU - Lin, YH AU - Molnár, József TI - Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions. JF - IN VIVO J2 - IN VIVO VL - 15 PY - 2001 IS - 2 SP - 151 EP - 156 PG - 6 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/1862584 ID - 1862584 N1 - Cited By :22 Export Date: 22 June 2023 CODEN: IVIVE Correspondence Address: Berek, L.; Blood Transfusion Center, Pecsi u. 4/b, Szeged 6721, Hungary Chemicals/CAS: ginsenoside, 74749-74-9; ginsenoside Rc, 11021-14-0; ginsenoside Rd, 52705-93-8; ginsenoside Re, 52286-59-6; ginsenoside Rg 1, 22427-39-0; solamargine, 20311-51-7; solasodine, 126-17-0; verapamil, 152-11-4, 52-53-9 AB - Solamargine, solasonine, ginsenosides and parishin-related compounds were investigated for their effects on mdr efflux pump of lymphoma cells, and their effects on T cell proliferative assays and cell mediated immune functions, antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell activity of human peripheral mononuclear cells. Solamargine and solasonine were the only drugs which inhibited all of the tested immune functions; however, ginsenoside Rc and Rd enhanced T cell proliferative assays and marginally increased the NK cell activity. The majority of the compounds were not able to reverse the multidrug resistance of mouse lymphoma cells. However, ginsenosides Rc, Rd and parishin C were able to moderately reduce the activity of the efflux pump. Parishin, parishin C and crude extract significantly enhanced the ADCC reaction. LA - English DB - MTMT ER - TY - THES AU - Szabó, Diána TI - Reversal of multidrug resistance in tumor cells. PB - Szegedi Tudományegyetem (SZTE) PY - 2001 SP - 54 UR - https://m2.mtmt.hu/api/publication/2514036 ID - 2514036 N1 - SZTE ÁOK Orvosi Mikrobiológiai és Immunbiológiai Intézet LA - English DB - MTMT ER - TY - JOUR AU - Sharples, D AU - Hajós, György AU - Riedl, Zsuzsanna AU - Csányi, Dorottya AU - Molnár, József AU - Szabó, Diána TI - Ellipticine analogues and related compounds as inhibitors of reverse transcriptase and as inhibitors of the efflux pump JF - ARCHIV DER PHARMAZIE J2 - ARCH PHARM VL - 334 PY - 2001 IS - 8-9 SP - 269 EP - 274 PG - 6 SN - 0365-6233 DO - 10.1002/1521-4184(200109)334:8/9<269::aid-ardp269>3.0.co;2-# UR - https://m2.mtmt.hu/api/publication/1091894 ID - 1091894 N1 - University of Manchester, School of Pharmacy and Pharmaceutical Sciences, Oxford Road, Manchester, M13 9PL, United Kingdom Chemical Research Center, Institute of Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest, Hungary University of Szeged, Faculty of Medicine, Dept of Medical Microbiology, Dom tr 10, H-6720 Szeged, Hungary Cited By :17 Export Date: 7 March 2020 CODEN: ARPMA Correspondence Address: Hajós, G.; Chemical Research Center, Institute of Chemistry, Hungarian Academy of Sciences, POB 17, H-1525 Budapest, Hungary; email: ghajos@cric.chemres.hu Chemicals/CAS: DNA, 9007-49-2; RNA directed DNA polymerase, 37213-50-6, 9068-38-6 AB - Ten polycyclic derivatives related to ellipticine have been synthesised and tested for their intercalating, reverse transcriptase (RT) inhibitory and multidrug resistance efflux pump inhibitory properties. The intercalating activity and the RT inhibitory activity of the derivatives suggest that ellipticine analogues bind at an allosteric binding site on RT or that this inhibition could be controlled at the DNA level. The MDR efflux pump inhibitory activities of these derivatives, however, appears to be unrelated to the DNA binding ability. LA - English DB - MTMT ER - TY - THES AU - Szabó, Diána TI - Reversal of multidrug resistance in tumor cells In Vitro PB - Szegedi Tudományegyetem (SZTE) PY - 2001 SP - 63 UR - https://m2.mtmt.hu/api/publication/31255439 ID - 31255439 LA - English DB - MTMT ER - TY - PAT AU - Szabó, Diána AU - Molnár, József TI - Neue substituierte Disiloxane, Verfahren zu ihrer Herstellung und ihre Verwendung zur Umkehrung der Multidrugresistenz (Mdr) CY - Country:10011(5) PY - 2000 UR - https://m2.mtmt.hu/api/publication/2518758 ID - 2518758 LA - German DB - MTMT ER - TY - JOUR AU - Hajós, György AU - Riedl, Zsuzsanna AU - Molnár, József AU - Szabó, Diána TI - Nonnucleoside reverse transcriptase inhibitors JF - DRUGS OF THE FUTURE J2 - DRUG FUTURE VL - 25 PY - 2000 IS - 1 SP - 47 EP - 62 PG - 16 SN - 0377-8282 DO - 10.1358/dof.2000.025.01.858638 UR - https://m2.mtmt.hu/api/publication/1091890 ID - 1091890 LA - English DB - MTMT ER - TY - JOUR AU - Molnár, József AU - Szabó, Diána AU - Pusztai, Rozália AU - Mucsi, I AU - Adalbert, Lívia AU - Ocsovszki, Imre AU - Kawata, E AU - Shoyama, Y TI - Membrane associated antitumor effects of crocine-, ginsenoside- and cannabinoid derivates JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 20 PY - 2000 IS - 2A SP - 861 EP - 867 PG - 7 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1766763 ID - 1766763 N1 - Megjegyzés-21005764 PubMed ID: 10810367 Chemicals/CAS: Antineoplastic Agents; Cannabinoids; Carotenoids, 36-88-4; crocin, 42553-65-1; Cyclohexenes; Glucosides; picrocrocin, 138-55-6; Saponins; Terpenes; Tetrahydrocannabinol, 1972-08-3; Verapamil, 52-53-9 Manufacturers: United Nations Narcotics Lab, Austria; Alkaloida Chemical Works, Hungary LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Keyzer, H AU - Kaiser, HE AU - Molnár, József TI - Reversal of multidrug resistance of tumor cells. JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 20 PY - 2000 IS - 6B SP - 4261 EP - 4274 PG - 14 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1862585 ID - 1862585 N1 - RF: 125 AB - Drug resistance to chemotherapy is rapidly emerging. Resistance to one drug carries over resistance to unrelated anticancer drugs leading to multidrug resistance (MDR). A major factor of MDR is P-glycoprotein (P-gp) mediated ABC transport found in many eukaryotic cells. P-gp acts as a drug eMux pump. The mdr1 gene involved in P-gp 170 protein production is localized in the human chromosome 7 band p2 1.0-21.1. Point mutations after cross-resistance patterns. A variety of stimuli increase the expression of the mdr1 gene: lowered extracellular pH, heat shock, arsenite, cytotoxic agents, anticancer drugs, transfection with oncogenes, HIV-I, and UV-irradiation. An alternative hypothesis to the efflux pump claims that P-gp modifies the intracellular environment to reduce accumulation of anticancer drugs in cancer cells by creating ionic or proton gradients. Chemosensitizers that block P-gp drug extrusion are generally lipid-soluble at physiological pH, possess a basic nitrogen atom and at least two co-planar rings. P-gp blocking does not depend on drug chirality. This opens the way of treating P-gp related MDR with chiral versions of drugs relatively harmless in terms of side-effects. We believe that resistance modifiers combined with cytostatics will chemotherapeutically be more effective for cancer patients. LA - English DB - MTMT ER - TY - JOUR AU - Molnár, József AU - Gunics, Gy AU - Miskolczi, Cs AU - Szabó, Diána AU - Pusztai, Rozália AU - Kristiansen, J AU - Varga, A AU - Keyzer, H TI - Models for reversal of resistance JF - JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY J2 - J ANTIMICROB CHEMOTH VL - 44 PY - 1999 IS - Suppl A SP - 15 SN - 0305-7453 UR - https://m2.mtmt.hu/api/publication/2398291 ID - 2398291 LA - English DB - MTMT ER - TY - JOUR AU - Motohashi, N AU - Kurihara, T AU - Sakagami, H AU - Szabó, Diána AU - Csuri, K AU - Molnár, József TI - Chemical structure and tumor type specificity of "half-mustard type" phenothiazines. JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 19 PY - 1999 IS - 3A SP - 1859 EP - 1864 PG - 6 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1862586 ID - 1862586 N1 - Megjegyzés-21808299 Z9: 13 WC: Oncology AB - The antiproliferative activity of six "half-mustard type" phenothiazines against a total of 54 tumor cell lines: 4 leukemia, 9 non-small-cell lung, 7 colon-, 5 CNS-, 8 melanoma, 6 ovarian-, 8 renal-, 1 prostate and 6 breast cancer was determined by NCI-Information Intensive-Approach. The C-2 position of phenothiazines were substituted with H, Cl and CF3 groups. The half-mustard and ring system was linked either by a propylene or a butylene bridge. Colon-cancer cell showed the highest sensitivity against "half-mustard type" phenothiazines, followed by leukemia, melanoma, prostate-, CNS-, breast-, lung-, renal and ovarian cancer cells. These data suggest the "cancer-type-specific" antitumor action of "half-mustard type" phenothiazines. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Szabó, Gábor AU - Ocsovszki, Imre AU - Aszalos, A AU - Molnár, József TI - Anti-psychotic drugs reverse multidrug resistance of tumor cell lines and human AML cells ex-vivo JF - CANCER LETTERS J2 - CANCER LETT VL - 139 PY - 1999 IS - 1 SP - 115 EP - 119 PG - 5 SN - 0304-3835 DO - 10.1016/S0304-3835(99)00020-8 UR - https://m2.mtmt.hu/api/publication/1637992 ID - 1637992 N1 - Z9: 32 LA - English DB - MTMT ER - TY - JOUR AU - Mándi, Yvette AU - Ocsovszki, Imre AU - Szabó, Diána AU - Nagy, Z AU - Nelson, J AU - Molnár, József TI - Nitric oxide production and MDR expression by human brain endothelial cells JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 18 PY - 1998 IS - 4C SP - 3049 EP - 3052 PG - 4 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1158097 ID - 1158097 LA - English DB - MTMT ER - TY - JOUR AU - Molnár, József AU - Szabó, Diána AU - Mándi, Yvette AU - Mucsi, I AU - Fischer, J AU - Varga, A AU - Konig, S AU - Motohashi, N TI - Multidrug resistance reversal in mouse lymphoma cells by heterocyclic compounds JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 18 PY - 1998 IS - 4C SP - 3033 EP - 3038 PG - 6 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1158095 ID - 1158095 N1 - Department of Microbiology, Albert Szent-Györgyi Med. Univ., Szeged, Hungary Department of Biochemistry, Albert Szent-Györgyi Med. Univ., Szeged, Hungary Institute of Biochemistry, Department of Molecular Parasitology, Humboldt University Berlin, Germany Faculty of Medicine, Institute of Microbiology, Albert Szent-Gyorgyi Med. University, Dom ter 10, H-6720 Szeged, Hungary Cited By :56 Export Date: 5 December 2023 CODEN: ANTRD Correspondence Address: Molnar, J.; Faculty of Medicine, Dom ter 10, Szeged H-6720, Hungary Chemicals/CAS: Adjuvants, Immunologic; Antineoplastic Agents; Fluorescent Dyes; Heterocyclic Compounds; P-Glycoprotein; Rhodamine 123, 62669-70-9; Rhodamines Manufacturers: egis, Hungary; hoffmann la roche, Switzerland; lachema, Czech Republic; richter LA - English DB - MTMT ER - TY - CHAP AU - Molnár, József AU - Szabó, Diána AU - Miskolci, Cs AU - Nacsa, J AU - Kawase, M AU - Saito, S AU - Motohashi, N ED - Chakrabarty, A N ED - Molnár, József ED - Dastidar, Sujata G ED - Motohashi, Noboru TI - Effect of some new 3-benzazepines on plasmid DNA , mdr p-glycoprotein and reverse transcriptase of leukaemia T2 - Non antibiotics: A New Class of Unrecognised Antimicrobics PB - National Institute of Science Communication and Information Resources CY - New Delhi SN - 8172361831 PY - 1998 SP - 272 EP - 280 PG - 9 UR - https://m2.mtmt.hu/api/publication/2515778 ID - 2515778 N1 - as chapter 23. LA - English DB - MTMT ER - TY - JOUR AU - Nacsa, J AU - Nagy, L AU - Sharples, D AU - Hever, A AU - Szabó, Diána AU - Ocsovszki, Imre AU - Varga, A AU - Konig, S AU - Molnár, József TI - The inhibition of SOS-responses and MDR by phenothiazine-metal complexes. JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 18 PY - 1998 IS - 4C SP - 3093 EP - 3098 PG - 6 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1862587 ID - 1862587 AB - The gene of multidrug resistance (mdr) is inducible by different environmental stresses (SOS gene). We tested the inhibitory action of some new metal complexes of phenothiazines on megacin encoding bacterial gene induced by mitomycin-C as an example of "SOS induction" and on efflux pump of mouse lymphoma cells. The interaction of compounds to DNA was measured by thermal stability of DNA. It was found that metal co-ordination complexes of trifluoperazine (TFP) and chlorpromazine (CPZ) added before mitomycin administration have an inhibitory action on megacine induction. The TFP-V(IV) complex was effective at a lower concentration than TFP alone. The inhibitory effect of some metal coordinating complexes (TFP-Cu(II) and TFP- V(IV)) exceeded the action of TFP alone on efflux pumps. We propose that these compounds can form a complex with the regulatory protein or DNA resulting in the inhibition of SOS response and inhibit the mdr function by inactivating the P-glycoprotein as well. LA - English DB - MTMT ER -