TY - JOUR AU - Enyedy, Éva Anna AU - Giricz, Anett AU - Petrasheuskaya, Tatsiana AU - Mészáros, János Péter AU - May, Nóra Veronika AU - Spengler, Gabriella AU - Kovács, Ferenc AU - Molnár, Barnabás AU - Nagyné Frank, Éva TI - Comparative Solution Equilibrium Studies on Anticancer Estradiol-Based Conjugates and Their Copper Complexes JF - INORGANICS J2 - INORGANICS VL - 12 PY - 2024 IS - 2 PG - 21 SN - 2304-6740 DO - 10.3390/inorganics12020049 UR - https://m2.mtmt.hu/api/publication/34556458 ID - 34556458 AB - Steroids are often considered valuable molecular tools for the development of anticancer agents with improved pharmacological properties. Conjugation of metal chelating moieties with a lipophilic sterane backbone is a viable option to obtain novel anticancer compounds. In this work, two estradiol-based hybrid molecules (PMA-E2 and DMA-E2) with an (N,N,O) binding motif and their Cu(II) complexes were developed. The lipophilicity, solubility, and acid-base properties of the novel ligands were determined by the combined use of UV-visible spectrophotometry, pH-potentiometry, and 1H NMR spectroscopy. The solution speciation and redox activity of the Cu(II) complexes were also investigated by means of UV-visible and electron paramagnetic resonance spectroscopy. Two structurally analogous ligands (PMAP and DMAP) were also included in the studies for better interpretation of the solution chemical data obtained. Three pKa values were determined for all ligands, revealing the order of the deprotonation steps: pyridinium-NH+ or NH(CH3)2+, secondary NH2+, and OH. The dimethylamine derivatives (DMA-E2, DMAP) are found in their H2L+ forms in solution at pH 7.4, whereas the fraction of the neutral HL species is significant (34–37%) in the case of the pyridine nitrogen-containing derivatives (PMA-E2, PMAP). Both estradiol derivatives were moderately cytotoxic in human breast (MCF-7) and colon adenocarcinoma (Colo-205) cells (IC50 = 30–63 μM). They form highly stable complexes with Cu(II) ions capable of oxidizing ascorbate and glutathione. These Cu(II) complexes are somewhat more cytotoxic (IC50 = 15–45 μM) than their corresponding ligands and show a better selectivity profile. LA - English DB - MTMT ER - TY - JOUR AU - Hegedűs, Dóra AU - Szemerédi, Nikoletta AU - Gábor, Maja AU - Sas, Judit AU - Belasri, Khadija AU - Szatmári, István AU - Spengler, Gabriella TI - Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 44 PY - 2024 IS - 3 SP - 1149 EP - 1160 PG - 12 SN - 0250-7005 DO - 10.21873/anticanres.16910 UR - https://m2.mtmt.hu/api/publication/34715381 ID - 34715381 N1 - Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary HUN-REN–SZTE Stereochemistry Research Group, University of Szeged, Szeged, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Export Date: 3 April 2024 CODEN: ANTRD Correspondence Address: Szatmári, I.; Institute of Pharmaceutical Chemistry, Hungary; email: szatmari.istvan@szte.hu Correspondence Address: Spengler, G.; Department of Medical Microbiology, Hungary; email: spengler.gabriella@med.u-szeged.hu Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; ethidium bromide, 1239-45-8; isoquinoline, 119-65-3; rhodamine 123, 62669-70-9; vemurafenib, 918504-65-1; adamantane, 281-23-2; Adamantane; Amines; Anti-Bacterial Agents; Antipsychotic Agents; Antiviral Agents Funding details: TKP-2021-EGA-32, ÚNKP-23-4-SZTE-347 Funding details: Hungarian Scientific Research Fund, OTKA, K-138871 Funding details: Magyar Tudományos Akadémia, MTA, ÚNKP-23-5-SZTE-677 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, BO/00158/22/5 Funding details: Innovációs és Technológiai Minisztérium Funding text 1: The Authors thank the Hungarian Research Foundation (OTKA No. K-138871), the Ministry of Human Capacities, Hungary grant, TKP-2021-EGA-32. N. S. was supported by the ÚNKP-23-4-SZTE-347 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund. G.S. was supported by the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences and by the ÚNKP-23-5-SZTE-677 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Balázs AU - Szemerédi, Nikoletta AU - Csikós, Orsolya AU - Kiss, Tivadar AU - Veres, Katalin AU - Spengler, Gabriella AU - Csupor-Löffler, Boglárka AU - Csupor, Dezső TI - Chemical composition, antimicrobial and antiproliferative activity of the essential oil from Ambrosia artemisiifolia L JF - JOURNAL OF ESSENTIAL OIL RESEARCH J2 - J ESSENT OIL RES VL - 36 PY - 2024 IS - 1 SP - 30 EP - 42 PG - 13 SN - 1041-2905 DO - 10.1080/10412905.2024.2303449 UR - https://m2.mtmt.hu/api/publication/34501021 ID - 34501021 LA - English DB - MTMT ER - TY - JOUR AU - Pivarcsik, Tamás AU - Kiss, Márton Attila AU - Rapuš, Uroš AU - Kljun, Jakob AU - Spengler, Gabriella AU - Nagyné Frank, Éva AU - Turel, Iztok AU - Enyedy, Éva Anna TI - Organometallic Ru(II), Rh(III) and Re(I) complexes of sterane-based bidentate ligands: Synthesis, solution speciation, interaction with biomolecules and anticancer activity JF - DALTON TRANSACTIONS J2 - DALTON T VL - 53 PY - 2024 IS - 11 SP - 4984 EP - 5000 PG - 17 SN - 1477-9226 DO - 10.1039/D3DT04138G UR - https://m2.mtmt.hu/api/publication/34601216 ID - 34601216 AB - In this study, we present the synthesis, characterization and in vitro cytotoxicity of six organometallic [Ru(II)(η6-p-cymene)(N,N)Cl]Cl, [Rh(III)(η5-C5Me5)(N,N)Cl]Cl and [Re(I)(CO)3(N,N)Cl] complexes, in which the (N,N) ligands are sterane-based 2,2’-bipyridine derivatives (4-Me-bpy-St-OH,... LA - English DB - MTMT ER - TY - JOUR AU - Pósa, Vivien AU - Federa, Anja AU - Cseh, Klaudia AU - Wenisch, Dominik AU - Spengler, Gabriella AU - May, Nóra Veronika AU - Lihi, Norbert AU - Samu, Gergely Ferenc AU - Jakupec, Michael A. AU - Keppler, Bernhard K. AU - Kowol, Christian R. AU - Enyedy, Éva Anna TI - A Comparative Study on the Complexation of the Anticancer Iron Chelator VLX600 with Essential Metal Ions JF - INORGANIC CHEMISTRY J2 - INORG CHEM VL - 63 PY - 2024 IS - 5 SP - 2401 EP - 2417 PG - 17 SN - 0020-1669 DO - 10.1021/acs.inorgchem.3c03259 UR - https://m2.mtmt.hu/api/publication/34536068 ID - 34536068 N1 - Funding Agency and Grant Number: Austrian Science Fund [TKP-2021-EGA-32]; National Research Development and Innovation Office-NKFIA (Hungary) [P31923, UNKP-22-3-SZTE-447, LP2019-6/2019]; Austrian Science Fund (FWF) [6774]; University of Szeged Open Access Fund Funding text: This work was financially supported by the National Research Development and Innovation Office-NKFIA (Hungary) through project TKP-2021-EGA-32 (to E.A.E.), the Austrian Science Fund (FWF) grant P31923 (to C.K.), and the UNKP-22-3-SZTE-447 New National Excellence Program (to V.P.). The support of the "Lendulet" Programme (ELKH, LP2019-6/2019) and University of Szeged Open Access Fund (grant number: 6774) is also acknowledged (to E.A.E.). We thank the Core Facility X-ray Centre of the Faculty of Chemistry, University of Vienna, for crystal structure determination. LA - English DB - MTMT ER - TY - JOUR AU - Resende, D.I.S.P. AU - Durães, F. AU - Zubarioglu, S. AU - Freitas-Silva, J. AU - Szemerédi, Nikoletta AU - Pinto, M. AU - Pinto, E. AU - Martins, da Costa P. AU - Spengler, Gabriella AU - Sousa, E. TI - Antibacterial Potential of Symmetrical Twin-Drug 3,6-Diaminoxanthones JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 17 PY - 2024 IS - 2 PG - 18 SN - 1424-8247 DO - 10.3390/ph17020209 UR - https://m2.mtmt.hu/api/publication/34746290 ID - 34746290 N1 - Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, Matosinhos, 4450-208, Portugal ICBAS—Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Rua de Jorge Viterbo Ferreira, Porto, 228, 4050-313, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal Export Date: 19 March 2024 Correspondence Address: Sousa, E.; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Rua de Jorge Viterbo Ferreira, 228, Portugal; email: esousa@ff.up.pt Correspondence Address: Pinto, E.; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Av. General Norton de Matos s/n, Portugal; email: epinto@ff.up.pt Tradenames: Advance 300, Bruker, United States; ChemDraw, Perkin Elmer; CLARIOstar Plus, BMG Labtech, Germany; DGV-20A5, Shimadzu, Japan; Kofler, Wagner and Munz, Germany; LCMS Lab Solutions software version 3.50 SP2, Shimadzu, Japan; Lux, Phenomenex; Multiscan EX, Thermo Labsystems, United States; Q Exactive, Thermo, Germany; Rheodyne 7725, Shimadzu, Japan; Waterchath B-480, BUCHI; Xcalibur 4.1.31.9 software, Thermo, Germany Manufacturers: BMG Labtech, Germany; BUCHI; Perkin Elmer; Phenomenex; Thermo, Germany; Wagner and Munz, Germany; Shimadzu, Japan; Bruker, United States; Thermo Labsystems, United States Funding details: 2022.00379, BO/00158/22/5 Funding details: European Commission, EC Funding details: Fundação para a Ciência e a Tecnologia, FCT, EXPL/CTA-AMB/0810/2021, PTDC/CTA-AMB/0853/2021, UIDP/04423/2020 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund, ERDF, NORTE-01-0145-FEDER-000040 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding text 1: This research was supported by national funds through the FCT—Foundation for Science and Technology within the scope of UIDB/04423/2020, UIDP/04423/2020 (Group of Marine Natural Products and Medicinal Chemistry CIIMAR), and under the projects EXPL/CTA-AMB/0810/2021 and PTDC/CTA-AMB/0853/2021, co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds, as well as R&D&I ATLANTIDA (reference NORTE-01-0145-FEDER-000040), supported by NORTE2020, through ERDF. D.I.S.P.R. acknowledges her individual researcher contract (2022.00379.CEECIND). Gabriella Spengler was supported by the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences. AB - Global health faces a significant issue with the rise of infectious diseases caused by bacteria, fungi, viruses, and parasites. The increasing number of multi-drug resistant microbial pathogens severely threatens public health worldwide. Antibiotic-resistant pathogenic bacteria, in particular, present a significant challenge. Therefore, there is an urgent need to identify new potential antimicrobial targets and discover new chemical entities that can potentially reverse bacterial resistance. The main goal of this research work was to create and develop a library of 3,6-disubstituted xanthones based on twin drugs and molecular extension approaches to inhibit the activity of efflux pumps. The process involved synthesizing 3,6-diaminoxanthones through the reaction of 9-oxo-9H-xanthene-3,6-diyl bis(trifluoromethanesulfonate) with various primary and secondary amines. The resulting 3,6-disubstituted xanthone derivatives were then tested for their in vitro antimicrobial properties against a range of pathogenic strains and their efficacy in inhibiting the activity of efflux pumps, biofilm formation, and quorum-sensing. Several compounds have exhibited effective antibacterial properties against the Gram-positive bacterial species tested. Xanthone 16, in particular, has demonstrated exceptional efficacy with a remarkable MIC of 11 µM (4 µg/mL) against reference strains Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, and 25 µM (9 µg/mL) against methicillin-resistant S. aureus 272123. Furthermore, some derivatives have shown potential as antibiofilm agents in a crystal violet assay. The ethidium bromide accumulation assay pinpointed certain compounds inhibiting bacterial efflux pumps. The cytotoxic effect of the most promising compounds was examined in mouse fibroblast cell line NIH/3T3, and two monoamine substituted xanthone derivatives with a hydroxyl substituent did not exhibit any cytotoxicity. Overall, the nature of the substituent was critical in determining the antimicrobial spectra of aminated xanthones. © 2024 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Ribeiro, Joana R. L. AU - Szemerédi, Nikoletta AU - Gonçalves, Bruno M. F. AU - Spengler, Gabriella AU - Afonso, Carlos A. M. AU - Ferreira, Maria-José U. TI - Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells JF - RSC MEDICINAL CHEMISTRY J2 - RSC MED CHEM PY - 2024 SN - 2632-8682 DO - 10.1039/D3MD00711A UR - https://m2.mtmt.hu/api/publication/34753868 ID - 34753868 N1 - This study was financially supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal (projects: PTDC/MED-QUI/30591/2017; 2022.05718.PTDC; UIDB/04138/2020, UIDP/ 04138/2020, PhD grant SFRH/BD/139760/2018) and the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences. We also thank COST Action RSC Medicinal Chemistry Research ArticleOpen Access Article. Published on 26 February 2024. Downloaded on 3/25/2024 5:44:13 AM.This article is licensed under aCreative Commons Attribution 3.0 Unported Licence. View Article Online RSC Med. Chem. This journal is © The Royal Society of Chemistry 2024 CA17104 STRATAGEM. The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project no. 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). AB - A set of twenty-three new andrographolide derivatives, bearing a nitrogen-containing moiety, is reported. Several derivatives were found to be promising leads for reversing cancer multidrug resistance. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Janovák, László AU - Abdelghafour, Mohamed M. AU - Takács, Tamás AU - Csanády, Miklós ifj. AU - Spengler, Gabriella AU - Szakács, László AU - Csanády, Miklós AU - Rovó, László TI - Új minimálinvazív kezelési lehetőségek jó- és rosszindulatú fül-orr-gégészeti betegségekben nanoszerkezetű hatóanyag-leadó rendszerek alkalmazásával = New minimally invasive treatment options in benign and malignant otorhinolaryngological diseases using nanostructured drug delivery systems JF - ORVOSI HETILAP J2 - ORV HETIL VL - 165 PY - 2024 IS - 10 SP - 370 EP - 378 PG - 9 SN - 0030-6002 DO - 10.1556/650.2024.32978 UR - https://m2.mtmt.hu/api/publication/34729015 ID - 34729015 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Abu Ghazal, Tasneem AU - Veres, Katalin AU - Vidács, Lívia Melinda AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Berkecz, Róbert AU - Hohmann, Judit TI - Furanonaphthoquinones, Diterpenes, and Flavonoids from Sweet Marjoram and Investigation of Antimicrobial, Bacterial Efflux, and Biofilm Formation Inhibitory Activities JF - ACS OMEGA J2 - ACS OMEGA VL - 8 PY - 2023 IS - 38 SP - 34816 EP - 34825 PG - 10 SN - 2470-1343 DO - 10.1021/acsomega.3c03982 UR - https://m2.mtmt.hu/api/publication/34147029 ID - 34147029 N1 - Funding Agency and Grant Number: National Research,Development and Innovation Fund (NKFI), Hungary [K135845]; Ministry of Innovation and Technology of Hungary [TKP2021-EGA-32] Funding text: This research was supported by the National Research,Development and Innovation Fund (NKFI), Hungary (grant number K135845),and by the Ministry of Innovation and Technology of Hungary (grantnumber TKP2021-EGA-32). LA - English DB - MTMT ER - TY - JOUR AU - Almeida, M.C. AU - Szemerédi, Nikoletta AU - Durães, F. AU - Long, S. AU - Resende, D.I.S.P. AU - Martins, da Costa P. AU - Pinto, M. AU - Spengler, Gabriella AU - Sousa, E. TI - Effect of Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones in the Virulence of Resistant Bacteria JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 12 PY - 2023 IS - 5 PG - 29 SN - 2079-6382 DO - 10.3390/antibiotics12050922 UR - https://m2.mtmt.hu/api/publication/34006534 ID - 34006534 N1 - Laboratório de Química Orgânica e Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal CIIMAR––Centro Interdisciplinar de Investigação Marinha e Ambiental, Terminal de Cruzeiros do Porto de Leixões, Matosinhos, 4450-208, Portugal Department of Medical Microbiology, Albert Szent-Gyorgyi Health Center and Albert Szent-Gyorgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Department of Bioengineering, Royal University of Phnom Penh, Russian Confederation Blvd, Phnom Penh, 12156, Cambodia ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Export Date: 9 June 2023 Correspondence Address: Resende, D.I.S.P.; Laboratório de Química Orgânica e Farmacêutica, Rua de Jorge Viterbo Ferreira 228, Portugal; email: dresende@ff.up.pt Correspondence Address: Sousa, E.; Laboratório de Química Orgânica e Farmacêutica, Rua de Jorge Viterbo Ferreira 228, Portugal; email: esousa@ff.up.pt Chemicals/CAS: carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; doxorubicin, 23214-92-8, 25316-40-9; fluorine, 7782-41-4 Tradenames: Advance 300, Bruker, Germany; AS3000, Thermo, United States; ChromQuest, Thermo, United States; HPLC system, Thermo, United States; Orbitrap, Thermo, United States; Q Exactive, Thermo, United States; SPD-M20A, Shimadzu, Japan; Xcalibur, Thermo, United States Manufacturers: Bruker, Germany; Wagner and Munz, Germany; Shimadzu, Japan; Thermo, United States Funding details: 2020/2021, 2022.00379 Funding details: European Commission, EC Funding details: Fundação para a Ciência e a Tecnologia, FCT, EXPL/CTA-AMB/0810/2021, PTDC/CTA-AMB/0853/2021, UIDP/04423/2020 Funding details: European Regional Development Fund, ERDF, NORTE-01-0145-FEDER-000040 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding text 1: This research was supported by national funds through the FCT—Foundation for Science and Technology within the scope of UIDB/04423/2020, UIDP/04423/2020 (Group of Marine Natural Products and Medicinal Chemistry CIIMAR), and under the projects EXPL/CTA-AMB/0810/2021 and PTDC/CTA-AMB/0853/2021, co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds, as well as R&D&I ATLANTIDA (reference NORTE-01-0145-FEDER-000040), supported by NORTE2020, through ERDF. Mariana C. Almeida acknowledges the BYT+ scholarship 2020/2021 to CIIMAR and Foundation Amadeu Dias (Master Student Scholarship) and FCT for the individual PhD grant (2021.05224.BD). Furthermore, Diana I. S. P. Resende acknowledges her individual researcher contract (2022.00379.CEECIND). AB - Drug resistance is rising to alarming levels, constituting one of the major threats to global health. The overexpression of efflux pumps and the formation of biofilms constitute two of the most common resistance mechanisms, favoring the virulence of bacteria. Therefore, the research and development of effective antimicrobial agents that can also counteract resistance mechanisms are extremely important. Pyrazino[2,1-b]quinazoline-3,6-diones, from marine and terrestrial organisms and simpler synthetic analogues, were recently disclosed by us as having relevant antimicrobial properties. In this study, using a multi-step approach, it was possible to synthesize new pyrazino[2,1-b]quinazoline-3,6-diones focusing on compounds with fluorine substituents since, to the best of our knowledge, the synthesis of fluorinated fumiquinazoline derivatives had not been attempted before. The new synthesized derivatives were screened for antibacterial activity and, along with previously synthetized pyrazino[2,1-b]quinazoline-3,6-diones, were characterized for their antibiofilm and efflux-pump-inhibiting effects against representative bacterial species and relevant resistant clinical strains. Several compounds showed relevant antibacterial activity against the tested Gram-positive bacterial species with MIC values in the range of 12.5–77 μM. Furthermore, some derivatives showed promising results as antibiofilm agents in a crystal violet assay. The results of the ethidium bromide accumulation assay suggested that some compounds could potentially inhibit bacterial efflux pumps. © 2023 by the authors. LA - English DB - MTMT ER - TY - BOOK AU - Burián, Katalin AU - Endrész, Valéria AU - Megyeri, Klára AU - Mosolygó, Tímea AU - Orosz, László AU - Somogyvári, Ferenc AU - Spengler, Gabriella AU - Bogdanov, Anita AU - Virók, Dezső ED - Burián, Katalin TI - ORVOSI MIKROBIOLÓGIA. Gyakorlati jegyzet I-II. kötet TS - Gyakorlati jegyzet I-II. kötet PB - SZTE SZAOK Orvosi Mikrobiológiai Intézet CY - Szeged PY - 2023 SN - 9789633069332 UR - https://m2.mtmt.hu/api/publication/34747744 ID - 34747744 N1 - (2. javított kiadás) LA - Hungarian DB - MTMT ER - TY - JOUR AU - Dömötör, Orsolya AU - Teixeira, Ricardo G. AU - Spengler, Gabriella AU - Avecilla, Fernando AU - Marques, Fernanda AU - Lenis-Rojas, Oscar A. AU - Matos, Cristina P. AU - de Almeida, Rodrigo F.M. AU - Enyedy, Éva Anna AU - Tomaz, Ana Isabel TI - Ruthenium(II) polypyridyl complexes with benzothiophene and benzimidazole derivatives: Synthesis, antitumor activity, solution studies and biospeciation JF - JOURNAL OF INORGANIC BIOCHEMISTRY J2 - J INORG BIOCHEM VL - 238 PY - 2023 PG - 15 SN - 0162-0134 DO - 10.1016/j.jinorgbio.2022.112058 UR - https://m2.mtmt.hu/api/publication/33208800 ID - 33208800 N1 - Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Centro de Química Estrutural, Institute of Molecular Sciences, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Lisboa, 1049-016, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Universidade da Coruña, Grupo NanoToxGen, Centro de Investigacións Científicas Avanzadas (CICA), Departamento de Química, Facultade de Ciencias, Campus de A Coruña, Coruña, 15071A, Spain Centro de Ciências e Tecnologias Nucleares and Departamento de Ciências e Engenharia Nucleares, Instituto Superior Técnico, Universidade de Lisboa, EN 10 (km 139,7), 2695-066 Bobadela, Loures, Portugal Export Date: 15 February 2023 CODEN: JIBID Correspondence Address: Dömötör, O.; Department of Inorganic and Analytical Chemistry, Dóm tér 7, Hungary; email: domotor.o@chem.u-szeged.hu Correspondence Address: Tomaz, A.I.; Centro de Química Estrutural, Campo Grande, Portugal; email: aidiniz@fc.ul.pt Chemicals/CAS: benzothiophene, 95-15-8; ruthenium, 7440-18-8; Antineoplastic Agents; Benzimidazoles; benzothiophene; Coordination Complexes; Ruthenium; Thiophenes Funding details: UID/MULTI/04349/2019 Funding details: LA/P/0056/2020, UIDB/00100/2020, UIDP/00100/2020 Funding details: European Cooperation in Science and Technology, COST, CA18202 Funding details: Fundação para a Ciência e a Tecnologia, FCT Funding details: Ministério da Ciência, Tecnologia e Ensino Superior, MCTES Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, 2019/2020, PD 131472, TKP-2021-EGA-32 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, TÉT-PT-2018-00002 Funding text 1: This work was supported by National Research, Development and Innovation Fund through projects Portuguese-Hungarian Scientific & Technological Cooperation TÉT-PT-2018-00002 and FCT/NKFIH 2019/2020 ; PD 131472 , TKP-2021-EGA-32 and J. Bolyai Research Fellowship (O.D.). The support of the “ Lendület ” Programme (ELKH, LP2019-6/2019 ) is also acknowledged. Fundação para a Ciência e a Tecnologia, I.P./MCTES, Portugal (FCT) further supports Centro de Química Estrutural and Institute of Molecular Sciences through projects UIDB/00100/2020 , UIDP/00100/2020 and LA/P/0056/2020 . C2TN ( Centro de Ciências e Tecnologias Nucleares ) also acknowledges FCT for project UID/MULTI/04349/2019 . R.G. Teixeira and O.A. Lenis-Rojas acknowledge FCT for the Ph.D. Grant SFRH/BD/135830/2018 and for the CEEC2017 Initiative , respectively. This contribution is also based upon work from COST Action CA18202, NECTAR – Network for Equilibria and Chemical Thermodynamics Advanced Research , supported by COST ( European Cooperation in Science and Technology ). LA - English DB - MTMT ER - TY - CONF AU - Wirasisya, Dyke Gita AU - Barta, Anita AU - Spengler, Gabriella AU - Krystic, Gordana AU - Mertha, Gde AU - Hohmann, Judit ED - Hohmann, Judit TI - Investigation of antimicrobial and antitumor properties of selectedEuphorbiaceae species T2 - 4th Symposium of Young Researchers on Pharmacognosy PB - Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged C1 - Szeged PY - 2023 SP - 20 EP - 20 PG - 1 DO - 10.14232/syrmpnpr.2023.13 UR - https://m2.mtmt.hu/api/publication/33963567 ID - 33963567 LA - English DB - MTMT ER - TY - JOUR AU - Felegyi, Kristóf AU - Garádi, Zsófia AU - Rácz, Bálint AU - Tóth, Gábor AU - Papp, Viktor AU - Boldizsár, Imre AU - Dancsó, András AU - Spengler, Gabriella AU - Béni, Szabolcs AU - Ványolós, Attila TI - Polyporenic Acids from the Mushroom Buglossoporus quercinus Possess Chemosensitizing and Efflux Pump Inhibitory Activities on Colo 320 Adenocarcinoma Cells JF - JOURNAL OF FUNGI J2 - J FUNGI VL - 9 PY - 2023 IS - 9 PG - 12 SN - 2309-608X DO - 10.3390/jof9090923 UR - https://m2.mtmt.hu/api/publication/34139861 ID - 34139861 LA - English DB - MTMT ER - TY - JOUR AU - Ferencz, Elek AU - Spengler, Gabriella AU - Zupkó, István AU - Vollár, Martin AU - Zomborszki, Zoltán Péter AU - Kúsz, Norbert AU - Hohmann, Judit AU - Kovács, Balázs AU - Csupor, Dezső AU - Laczkó-Zöld, Eszter AU - Csupor-Löffler, Boglárka TI - Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines JF - ZEITSCHRIFT FÜR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES J2 - Z NATURFORSCH C VL - 78 PY - 2023 IS - 7-8 SP - 299 EP - 305 PG - 7 SN - 0939-5075 DO - 10.1515/znc-2022-0239 UR - https://m2.mtmt.hu/api/publication/33742452 ID - 33742452 AB - Common ragweed (Ambrosia artemisiifolia L.) is an invasive plant in Europe with spreading use in the contemporary folk medicine. The chemical composition of the above-ground parts is extensively studied, however, the metabolites of the roots are less discovered. By multiple chromatographic purification of the root extracts, we isolated thiophene A (1), n-dodecene (2), taraxerol-3-O-acetate (3), α-linoleic acid (4), (+)-pinoresinol (5), and thiophene E (7,10-epithio-7,9-tridecadiene-3,5,11-triyne-1,2-diol) (6). The 1H NMR data published earlier for 1 were supplemented together with the assignment of 13C NMR data. Thiophene E (6), which is reported for the first time from this species, exerted cytotoxic and antiproliferative effects on A-431 epidermoid skin cancer cells, whereas taraxerol-3-O-acetate (3) and α-linoleic acid (4) had slight antiproliferative effect on gynecological cancer cell lines. Thiophene E (6) and taraxerol-3-O-acetate (3) displayed antiproliferative and cytotoxic effects on MRC-5 fibroblast cells. Thiophene E (6) exerted weak antibacterial activity (MIC 25 μg/mL) on MRSA ATCC 43300, on Staphylococcus aureus ATCC 25923, Escherichia coli AG100 and E. coli ATCC 25922 both thiophenes were inactive. Although the isolated compounds exerted no remarkable cytotoxic or antiproliferative activities, the effects on MRC-5 fibroblast cells highlight the necessity of further studies to support the safety of ragweed root. LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Pivarcsik, Tamás AU - Gergő, Egri AU - Ugrai, Imre AU - Szatmári, István AU - Enyedy, Éva Anna TI - Organorhodium complexes of 8-hydroxyquinoline derivatives with antibacterial and antitumor effect JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 70 PY - 2023 IS - Supplement 1 SP - 81 EP - 82 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/34109620 ID - 34109620 LA - English DB - MTMT ER - TY - BOOK AU - Burián, Katalin AU - Endrész, Valéria AU - Megyeri, Klára AU - Mosolygó, Tímea AU - Orosz, László AU - Somogyvári, Ferenc AU - Spengler, Gabriella AU - Bogdanov, Anita AU - Virók, Dezső ED - Burián, Katalin TI - MEDICAL MICROBIOLOGY. Practical classes TS - Practical classes PB - SZTE SZAOK Orvosi Mikrobiológiai Intézet CY - Szeged PY - 2023 SN - 9789633069325 UR - https://m2.mtmt.hu/api/publication/34747796 ID - 34747796 N1 - Second edition LA - English DB - MTMT ER - TY - JOUR AU - Kristóf, Erzsébet AU - Rácz, Bálint AU - Szemerédi, Nikoletta AU - Dominguez-Álvarez, Enrique AU - Spengler, Gabriella TI - Anticancer activity of symmetrical selenoesters on breast cancer cell lines JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 70 PY - 2023 IS - Supplement 1 SP - 31 EP - 31 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/34109493 ID - 34109493 LA - English DB - MTMT ER - TY - JOUR AU - Krizkovska, Bara AU - Hoang, Lan AU - Brdova, Daniela AU - Klementova, Kristyna AU - Szemerédi, Nikoletta AU - Louckova, Anna AU - Kronusova, Olga AU - Spengler, Gabriella AU - Kastanek, Petr AU - Hajslova, Jana AU - Viktorova, Jitka AU - Lipov, Jan TI - Modulation of the bacterial virulence and resistance by well-known European medicinal herbs JF - JOURNAL OF ETHNOPHARMACOLOGY J2 - J ETHNOPHARMACOL VL - 312 PY - 2023 PG - 10 SN - 0378-8741 DO - 10.1016/j.jep.2023.116484 UR - https://m2.mtmt.hu/api/publication/33946542 ID - 33946542 N1 - Department of Biochemistry and Microbiology, UCT Prague, Faculty of Food and Biochemical Technology, Prague, Czech Republic Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Food Analysis and Nutrition, UCT Prague, Faculty of Food and Biochemical Technology, Prague, Czech Republic EcoFuel Laboratories Ltd., Prague, Czech Republic Export Date: 15 June 2023 CODEN: JOETD Correspondence Address: Lipov, J.; Department of Biochemistry and Microbiology, Czech Republic; email: lipovj@vscht.cz Chemicals/CAS: alcohol, 64-17-5; colistin, 1066-17-7, 1264-72-8; ethidium bromide, 1239-45-8; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; Anti-Bacterial Agents; Colistin; Plant Extracts Funding details: National Eye Institute, NEI, LX22NPO5103 Funding details: Technology Agency of the Czech Republic, TACR, FW03010400 Funding details: European Commission, EC Funding details: University of Cape Town, UCT, A1_FPBT_2022_001, A1_FPBT_2022_005, A2_FPBT_2022_063 Funding text 1: The project was funded by Technology Agency of the Czech Republic , (Programme TREND, ID Project No FW03010400 ) - Bioactive substances from organically produced traditional Czech herbs and crops and development of nano-encapsulated forms for use in dermatology, cosmetics and immunity support, and by National Institute of virology and bacteriology (Programme EXCELES, ID Project No. LX22NPO5103 ) - Funded by the European Union - Next Generation EU . It was also supported by the grants of UCT Specific university research – grant No. A2_FPBT_2022_063 , No. A1_FPBT_2022_001 and No. A1_FPBT_2022_005 . AB - Ethnopharmacological relevance: Salvia officinalis L., Sambucus nigra L., Matricaria chamomilla L., Agrimonia eupatoria L., Fragaria vesca L. and Malva sylvestris L. are plants that have a long tradition in European folk medicine. To this day, they are part of medicinal teas or creams that help with the healing of skin wounds and the treatment of respiratory or intestinal infections. However, so far these plants have not been investigated more deeply than in their direct antibacterial effect.Aim of the study: Our research is focused on adjuvants that inhibit the mechanism of antibiotic resistance or modulate bacterial virulence. Based on a preliminary screening of 52 European herbs, which commonly appear as part of tea blends or poultice. Six of them were selected for their ability to revert the resistant phenotype of nosocomial bacterial strains.Methods: Herbs selected for this study were obtained from commercially available sources. For the extraction of active compounds ethanol was used. Modulation of virulence was observed as an ability to inhibit bacterial cellto-cell communication using two mutant sensor strains of Vibrio campbellii. Biofilm formation, and planktonic cell adhesion was measured using a static antibiofilm test. Ethidium bromide assay was used to checked the potential of inhibition bacterial efflux pumps. The antibacterial activities of the herbs were evaluated against resistant bacterial strains using macro dilution methods.Results: Alcohol extracts had antibacterial properties mainly against Gram-positive bacteria. Of all of them, the highest antimicrobial activity demonstrated Malva sylvestris, killing both antibiotic resistant bacteria; Staphylococcus aureus with MIC of 0.8 g/L and Pseudomonas aeruginosa 0.7 g/L, respectively. Fragaria vesca extract (0.08 g/L) demonstrated strong synergism with colistin (4 mg/L) in modulating the resistant phenotype to colistin of Pseudomonas aeruginosa. Similarly, the extract of S. officinalis (0.21 g/L) reverted resistance to gentamicin (1 mg/ L) in S. aureus. However, Sambucus nigra and Matricaria chamomilla seem to be a very promising source of bacterial efflux pump inhibitors.Conclusion: The extract of F. vesca was the most active. It was able to reduce biofilm formation probably due to the ability to decrease bacterial quorum sensing. On the other hand, the activity of S. nigra or M. chamomilla in reducing bacterial virulence may be explained by the ability to inhibit bacterial efflux systems. All these plants have potential as an adjuvant for the antibiotic treatment. LA - English DB - MTMT ER - TY - JOUR AU - Mészáros, János Péter AU - Kovács, Hilda AU - Spengler, Gabriella AU - Kovács, Ferenc AU - Nagyné Frank, Éva AU - Enyedy, Éva Anna TI - A comparative study on the metal complexes of an anticancer estradiol-hydroxamate conjugate and salicylhydroxamic acid JF - JOURNAL OF INORGANIC BIOCHEMISTRY J2 - J INORG BIOCHEM VL - 244 PY - 2023 PG - 15 SN - 0162-0134 DO - 10.1016/j.jinorgbio.2023.112223 UR - https://m2.mtmt.hu/api/publication/33744665 ID - 33744665 N1 - MTA-SZTE Lendület Functional Metal Complexes Research Group, Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Export Date: 20 June 2023 CODEN: JIBID Correspondence Address: Mészáros, J.P.; MTA-SZTE Lendület Functional Metal Complexes Research Group, Dóm tér 7, Hungary Chemicals/CAS: estradiol, 50-28-2; ferric ion, 20074-52-6; ruthenium, 7440-18-8; salicylhydroxamic acid, 89-73-6; Antineoplastic Agents; Coordination Complexes; Estradiol; Ferric Compounds; Hydroxamic Acids; Ions; Ligands; Ruthenium; salicylhydroxamic acid Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, LP2019-6/2019, TKP-2021-EGA-32 Funding text 1: This work was financially supported by the National Research, Development and Innovation Office–NKFIA (Hungary) through project TKP-2021-EGA-32 and the support of the ‘Lendület’ Programme (ELKH (Hungary), LP2019-6/2019) is also acknowledged. LA - English DB - MTMT ER - TY - JOUR AU - Mészáros, János Péter AU - Kandioller, Wolfgang AU - Spengler, Gabriella AU - Prado-Roller, Alexander AU - Keppler, Bernhard K. AU - Enyedy, Éva Anna TI - Half-Sandwich Rhodium Complexes with Releasable N-Donor Monodentate Ligands: Solution Chemical Properties and the Possibility for Acidosis Activation JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 2 PG - 24 SN - 1999-4923 DO - 10.3390/pharmaceutics15020356 UR - https://m2.mtmt.hu/api/publication/33590772 ID - 33590772 N1 - MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 42, Vienna, A-1090, Austria Research Cluster “Translational Cancer Therapy Research”, University of Vienna, Währinger Str. 42, Vienna, A-1090, Austria Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, H-6725, Hungary Export Date: 28 September 2023 Correspondence Address: Mészáros, J.P.; MTA-SZTE Lendület Functional Metal Complexes Research Group, Dóm tér 7, Hungary; email: meszaros.janos@chem.u-szeged.hu Correspondence Address: Enyedy, É.A.; MTA-SZTE Lendület Functional Metal Complexes Research Group, Dóm tér 7, Hungary Chemicals/CAS: 1 methylimidazole, 616-47-7; ciprofloxacin, 85721-33-1, 86393-32-0, 128074-72-6, 128074-76-0, 192934-52-4, 93107-08-5, 86483-48-9, 96186-80-0; cotrimoxazole, 8064-90-2; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; norfloxacin, 70458-96-7 Tradenames: 0710A0, Thermo, United States; APEX II, Stoelting, Germany; Avance III HD, Bruker; Avance III HD, Bruker, United States; Cary 8454, Agilent, United States; D8, Stoelting, Germany; Multiscan EX, Thermo Labsystems, United States; X8, Stoelting, Germany Manufacturers: Bruker; Stoelting, Germany; Agilent, United States; Bruker, United States; Thermo, United States; Thermo Labsystems, United States Funding details: National Research, Development and Innovation Office, LP2019-6/2019, TKP-2021-EGA-32 Funding text 1: This work was supported by the National Research Development and Innovation Office of Hungary through project TKP-2021-EGA-32. The support of the “Lendület” Program (ELKH, LP2019-6/2019) is also acknowledged (É.A.E.). AB - Cancer chemotherapeutics usually have serious side effects. Targeting the special properties of cancer and activation of the anticancer drug in the tumor microenvironment in situ may decrease the intensity of the side effects and improve the efficacy of therapy. In this study, half-sandwich Rh complexes are introduced, which may be activated at the acidic, extracellular pH of the tumor tissue. The synthesis and aqueous stability of mixed-ligand complexes with a general formula of [Rh(η5-Cp*)(N,N/O)(N)]2+/+ are reported, where (N,N/O) indicates bidentate 8-quinolate, ethylenediamine and 1,10-phenanthroline and (N) represents the releasable monodentate ligand with a nitrogen donor atom. UV-visible spectrophotometry, 1H NMR, and pH-potentiometry were used to determine the protonation constants of the monodentate ligands, the proton dissociation constants of the coordinated water molecules in the aqua complexes, and the formation constants of the mixed-ligand complexes. The obtained data were compared to those of the analogous Ru(η6-p-cymene) complexes. The developed mixed-ligand complexes were tested in drug-sensitive and resistant colon cancer cell lines (Colo205 and Colo320, respectively) and in four bacterial strains (Gram-positive and Gram-negative, drug-sensitive, and resistant) at different pH values (5–8). The mixed-ligand complexes with 1-methylimidazole displayed sufficient stability at pH 7.4, and their activation was found in cancer cells with decreasing pH; moreover, the mixed-ligand complexes demonstrated antimicrobial activity in Gram-positive and Gram-negative bacteria, including the resistant MRSA strain. This study proved the viability of incorporating releasable monodentate ligands into mixed-ligand half-sandwich complexes, which is supported by the biological assays. LA - English DB - MTMT ER - TY - JOUR AU - Szemerédi, Nikoletta AU - Simona, Dobiasova AU - Jitka, Viktorova AU - Helena, Gbelcova AU - Enrique, Domingez-Álvarez AU - Spengler, Gabriella TI - Reversal of multidrug resistance by selenocompounds in 2D and 3D tumor cell cultures JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 70 PY - 2023 IS - Supplement 1 SP - 44 EP - 44 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/34109606 ID - 34109606 LA - English DB - MTMT ER - TY - JOUR AU - Petrasheuskaya, Tatsiana AU - Kovács, Ferenc AU - Igaz, Nóra AU - Rónavári, Andrea AU - Hajdu, Bálint AU - Nagyné Bereczki, Laura AU - May, Nóra Veronika AU - Spengler, Gabriella AU - Gyurcsik, Béla AU - Csontné Kiricsi, Mónika AU - Nagyné Frank, Éva AU - Enyedy, Éva Anna TI - Estradiol-Based Salicylaldehyde (Thio)semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities JF - MOLECULES J2 - MOLECULES VL - 28 PY - 2023 IS - 1 PG - 26 SN - 1420-3049 DO - 10.3390/molecules28010054 UR - https://m2.mtmt.hu/api/publication/33416616 ID - 33416616 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office-NKFIA (Hungary) [TKP-2021-EGA-32]; OTKA [K124544]; 'Lendulet' Programme ELKH [LP2019-6/2019]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00158/22/5]; New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund [UNKP-22-5-SZTE-588] Funding text: This work was supported by the National Research, Development and Innovation Office-NKFIA (Hungary) through project TKP-2021-EGA-32 and OTKA grant K124544. The support of the 'Lendulet' Programme (ELKH, LP2019-6/2019) is also acknowledged. G.S. was supported by the Janos Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences and by the UNKP-22-5-SZTE-588 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. AB - A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% (v/v) DMSO/H2O. Estradiol-(T)SCs form mono-ligand complexes with Cu(II) ions and exhibit high stability with the exception of estradiol-SC. The Cu(II) complexes of estradiol-TSC and its N,N-dimethyl derivative displayed the highest cytotoxicity among the tested compounds in MCF-7, MCF-7 KCR, DU-145, and A549 cancer cells. The complexes do not damage DNA according to both in vitro cell-free and cellular assays. All the Cu(II)-TSC complexes revealed significant activity against the Gram-positive Staphylococcus aureus bacteria strain. Estradiol-TSCs showed efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not result in significant changes to physico-chemical and biological properties. LA - English DB - MTMT ER - TY - JOUR AU - Pilon, Adhan AU - Avecilla, Fernando AU - Rácz, Bálint AU - Gátszegi, Gerda T. AU - Spengler, Gabriella AU - Robalo, M. Paula AU - Enyedy, Éva Anna AU - Garcia, M. Helena AU - Valente, Andreia TI - Iron(II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: Ethylenebis(diphenylphosphane) vs. triphenylphosphane JF - JOURNAL OF INORGANIC BIOCHEMISTRY J2 - J INORG BIOCHEM VL - 249 PY - 2023 PG - 13 SN - 0162-0134 DO - 10.1016/j.jinorgbio.2023.112386 UR - https://m2.mtmt.hu/api/publication/34192715 ID - 34192715 N1 - This work was funded by Fundação para a Ciência e a Tecnologia (FCT), I.P./MCTES through national funds (PIDDAC) - UIDB/00100/2020, UIDP/00100/2020 and LA/P/0056/2020. Andreia Valente acknowledges CEECIND 2017 (CEECIND/01974/2017; acknowledging FCT, as well as POPH and FSE—European Social Fund). A. P. thank FCT for his Ph.D. Grant (SFRH/BD/139412/2018 and COVID/BD/153267/2023). B.R. was supported by the Szeged Foundation for Cancer Research (Szegedi Rákkutatásért Alapítvány). G.S. was supported by the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences and by the ÚNKP-22-5-SZTE-588 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. LA - English DB - MTMT ER - TY - JOUR AU - Pilon, Adhan AU - Avecilla, Fernando AU - Mohai, Miklós Péter AU - Enyedy, Éva Anna AU - Rácz, Bálint AU - Spengler, Gabriella AU - Garcia, M. Helena AU - Valente, Andreia TI - First iron(II) organometallic compound acting as ABCB1 inhibitor JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 256 PY - 2023 PG - 9 SN - 0223-5234 DO - 10.1016/j.ejmech.2023.115466 UR - https://m2.mtmt.hu/api/publication/33800320 ID - 33800320 N1 - Acknowledgments: This work was funded by Fundaç˜ao para a Ciˆencia e a Tecnologia (FCT), I.P./MCTES through national funds (PIDDAC) - UIDB/00100/ 2020 and LA/P/0056/2020. This work was also funded in the scope of the project PTDC/QUI-QIN/28662/2017 (FCT). Andreia Valente acknowledges CEECIND 2017 (CEECIND/01974/2017; acknowledging FCT, as well as POPH and FSE—European Social Fund). A. P. thanks FCT for his Ph.D. Grant (SFRH/BD/139412/2018 and COVID/BD/153267/ 2023). B.R. was supported by the Szeged Foundation for Cancer Research (Szegedi R´akkutat´as´ert Alapítv´any). G.S. was supported by the Janos Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences and by the ÚNKP-22-5-SZTE-588 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund AB - Appendix A. Supplementary data: Supplementary data to this article can be found online at https://doi. org/10.1016/j.ejmech.2023.115466 LA - English DB - MTMT ER - TY - JOUR AU - Pivarcsik, Tamás AU - Pósa, Vivien AU - Kovács, Hilda AU - May, Nóra Veronika AU - Spengler, Gabriella AU - Pósa, Szonja P. AU - Tóth, Szilárd AU - Nezafat Yazdi, Zeinab AU - Laczka, Csilla AU - Ugrai, Imre AU - Szatmári, István AU - Szakács, Gergely AU - Enyedy, Éva Anna TI - Metal Complexes of a 5-Nitro-8-Hydroxyquinoline-Proline Hybrid with Enhanced Water Solubility Targeting Multidrug Resistant Cancer Cells JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 1 PG - 27 SN - 1661-6596 DO - 10.3390/ijms24010593 UR - https://m2.mtmt.hu/api/publication/33532438 ID - 33532438 N1 - MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Centre for Structural Science, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Magyar Tudósok krt. 2, Budapest, H-1117, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Drug Resistance Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Magyar Tudósok krt. 2, Budapest, H-1117, Hungary National Laboratory for Drug Research and Development, Magyar Tudósok krt. 2, Budapest, H-1117, Hungary Institute of Pharmaceutical Chemistry and Stereochemistry Research Group, Eötvös Loránd Research Network, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, Vienna, A-1090, Austria Cited By :2 Export Date: 20 September 2023 Correspondence Address: Enyedy, É.A.; MTA-SZTE Lendület Functional Metal Complexes Research Group, Dóm tér 7, Hungary; email: enyedy@chem.u-szeged.hu Chemicals/CAS: ferric ion, 20074-52-6; ferrous ion, 15438-31-0; nitroxoline, 4008-48-4; zinc ion, 23713-49-7; proline, 147-85-3, 7005-20-1; ruthenium, 7440-18-8; water, 7732-18-5; Antineoplastic Agents; Coordination Complexes; Ferric Compounds; Ferrous Compounds; Ions; Ligands; nitroxoline; Organometallic Compounds; Proline; Ruthenium; Water Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, FK128751, K138518, LP2019-6/2019, RRF-2.3.1-21-2022-00015, TKP-2021-EGA-32 Funding text 1: This work was supported by National Research, Development and Innovation Fund (Hungary) through projects TKP-2021-EGA-32, FK128751, RRF-2.3.1-21-2022-00015 and K138518. The support of the “Lendület” Programme (ELKH, LP2019-6/2019) is also acknowledged (É.A.E.). AB - Multidrug resistance (MDR) in cancer is one of the major obstacles of chemotherapy. We have recently identified a series of 8-hydroxyquinoline Mannich base derivatives with MDR-selective toxicity, however with limited solubility. In this work, a novel 5-nitro-8-hydroxyquinoline-proline hybrid and its Rh(η5-C5Me5) and Ru(η6-p-cymene) complexes with excellent aqueous solubility were developed, characterized, and tested against sensitive and MDR cells. Complex formation of the ligand with essential metal ions was also investigated using UV-visible, circular dichroism, 1H NMR (Zn(II)), and electron paramagnetic resonance (Cu(II)) spectroscopic methods. Formation of mono and bis complexes was found in all cases with versatile coordination modes, while tris complexes were also formed with Fe(II) and Fe(III) ions, revealing the metal binding affinity of the ligand at pH 7.4: Cu(II) > Zn(II) > Fe(II) > Fe(III). The ligand and its Rh(III) complex displayed enhanced cytotoxicity against the resistant MES-SA/Dx5 and Colo320 human cancer cell lines compared to their chemosensitive counterparts. Both organometallic complexes possess high stability in solution, however the Ru(II) complex has lower chloride ion affinity and slower ligand exchange processes, along with the readiness to lose the arene ring that is likely connected to its inactivity. LA - English DB - MTMT ER - TY - JOUR AU - Rácz, Bálint AU - Kristof, Erzsebet AU - Kincses, Annamária AU - Dominguez-Alvarez, Enrique AU - Spengler, Gabriella TI - Antitumor Activity of Symmetrical Selenoesters in Doxorubicin Resistant Breast Cancer JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 43 PY - 2023 IS - 11 SP - 4865 EP - 4872 PG - 8 SN - 0250-7005 DO - 10.21873/anticanres.16683 UR - https://m2.mtmt.hu/api/publication/34231319 ID - 34231319 N1 - Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Instituto de Química Orgánica General (IQOG), CSIC, Madrid, Spain Export Date: 5 February 2024 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Correspondence Address: Dominguez-Alvarez, E.; Instituto de Química Orgánica General (IQOG), Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Chemicals/CAS: adenosine triphosphatase, 37289-25-1, 9000-83-3; doxorubicin, 23214-92-8, 25316-40-9; Adenosine Triphosphatases; Doxorubicin; Esters Funding details: PID2022-136438OB-I00 Funding details: European Commission, EC, BO/00158/22/5 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Ministerio de Ciencia e Innovación, MICINN Funding details: European Regional Development Fund, ERDF Funding details: Agencia Estatal de Investigación, AEI Funding text 1: The study was supported by the following organizations and grants: Szeged Foundation for Cancer Research (Szegedi Rákkutatásért Alapítvány), Grant PID2022-136438OB-I00 funded by MCIN/AEI/ 10.13039/501100011033, European Regional Development Fund - "A way of making Europe" by the European Union. G.S. was supported by the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences. LA - English DB - MTMT ER - TY - JOUR AU - Rácz, Bálint AU - Kincses, Annamária AU - Laczi, Krisztián AU - Rákhely, Gábor AU - Domínguez-Álvarez, Enrique AU - Spengler, Gabriella TI - Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 2 PG - 13 SN - 1999-4923 DO - 10.3390/pharmaceutics15020610 UR - https://m2.mtmt.hu/api/publication/33641641 ID - 33641641 N1 - További támogatások: SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine, János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences, The study was supported by the Szeged Foundation for Cancer Research (Szegedi Rákkutatásért Alapítvány) AB - Recently, selenium containing derivatives have attracted more attention in medicinal chemistry. In the present work, the anticancer activity of symmetrical selenoesters was investigated by studying the reversal of efflux pump-related and apoptosis resistance in sensitive and resistant human colon adenocarcinoma cells expressing the ABCB1 protein. The combined effect of the compounds with doxorubicin was demonstrated with a checkerboard assay. The ABCB1 inhibitory and the apoptosis-inducing effects of the derivatives were measured with flow cytometry. Whole transcriptome sequencing was carried out on Illumina platform upon the treatment of resistant cells with the most potent derivatives. One ketone and three methyl ester selenoesters showed synergistic or weak synergistic interaction with doxorubicin, respectively. Ketone selenoesters were the most potent ABCB1 inhibitors and apoptosis inducers. Nitrile selenoesters could induce moderate early and late apoptotic processes that could be explained by their ABCB1 modulating properties. The transcriptome analysis revealed that symmetrical selenoesters may influence the redox state of the cells and interfere with metastasis formation. It can be assumed that these symmetrical selenocompounds possess toxic, DNA-damaging effects due to the presence of two selenium atoms in the molecule, which may be augmented by the presence of symmetrical groups. LA - English DB - MTMT ER - TY - JOUR AU - Rácz, Bálint AU - Spengler, Gabriella TI - Repurposing Antidepressants and Phenothiazine Antipsychotics as Efflux Pump Inhibitors in Cancer and Infectious Diseases JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 12 PY - 2023 IS - 1 PG - 18 SN - 2079-6382 DO - 10.3390/antibiotics12010137 UR - https://m2.mtmt.hu/api/publication/33558152 ID - 33558152 N1 - Correspondence Address: Spengler, G.; Department of Medical Microbiology, Szeged, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Funding details: BO/00158/22/5 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: B.R. was supported by the Szeged Foundation for Cancer Research (Szegedi Rákkutatásért Alapítvány). G.S. was supported by the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences. AB - Multidrug resistance (MDR) is a major obstacle in the therapy of infectious diseases and cancer. One of the major mechanisms of MDR is the overexpression of efflux pumps (EPs) that are responsible for extruding antimicrobial and anticancer agents. EPs have additional roles of detoxification that may aid the development of bacterial infection and the progression of cancer. Therefore, targeting EPs may be an attractive strategy to treat bacterial infections and cancer. The development and discovery of a new drug require a long timeline and may come with high development costs. A potential alternative to reduce the time and costs of drug development is to repurpose already existing drugs. Antidepressants and antipsychotic agents are widely used in clinical practice in the treatment of psychiatric disorders and some somatic diseases. Antidepressants and antipsychotics have demonstrated various beneficial activities that may be utilized in the treatment of infections and cancer. This review aims to provide a brief overview of antibacterial and anticancer effects of selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) and phenothiazine antipsychotics, while focusing on EPs. However, it should be noted that the antimicrobial activity of a traditionally non-antibiotic drug may have clinical implications regarding dysbiosis and bacterial MDR. LA - English DB - MTMT ER - TY - JOUR AU - Ribeiro, Nádia AU - Bulut, Ipek AU - Sergi, Baris AU - Pósa, Vivien AU - Spengler, Gabriella AU - Sciortino, Giuseppe AU - André, Vânia AU - Ferreira, Liliana P. AU - Biver, Tarita AU - Ugone, Valeria AU - Garribba, Eugenio AU - Costa-Pessoa, João AU - Enyedy, Éva Anna AU - Acilan, Ceyda AU - Correia, Isabel TI - Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) complexes JF - FRONTIERS IN CHEMISTRY J2 - FRONT CHEM VL - 11 PY - 2023 PG - 17 SN - 2296-2646 DO - 10.3389/fchem.2023.1106349 UR - https://m2.mtmt.hu/api/publication/33708889 ID - 33708889 N1 - Funding Agency and Grant Number: Centro de Quimica Estrutural - Fundacao para a Ciencia e Tecnologia (FCT) [UIDB/00100/2020, UIDP/00100/2020, LA/P/0056/2020]; Programa Operacional Regional de Lisboa 2020; FCT [SFRH/BD/135797/2018]; VA [CEECIND/00283/2018]; Portuguese-Hungarian Scientific and Technological Cooperation FCT/NKFIH 2019/2020; NKFIH, Hungary [TKP-2021-EGA-32]; COST (European Cooperation in Science and Technology) [CA18202]; Koc University School of Medicine (KUSOM); Presidency of Turkey, Presidency of Strategy and Budget; Fondazione di Sardegna; MICINN' Juan de la Cierva program [FJC 2019-039135-I]; Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) [UIDB/04046/2020, UIDP/04046/2020]; NECL [22096]; [PTDC/QUI-QIN/0586/2020] Funding text: This work was supported by Centro de Quimica Estrutural, which is financed by national funds from Fundacao para a Ciencia e Tecnologia (FCT), projects UIDB/00100/2020, UIDP/00100/2020 and LA/P/0056/2020, and Programa Operacional Regional de Lisboa 2020. We also thank project PTDC/QUI-QIN/0586/2020; NR acklowledges FCT for SFRH/BD/135797/2018 and VA for CEECIND/00283/2018 grants. This work was supported by the Portuguese-Hungarian Scientific and Technological Cooperation FCT/NKFIH 2019/2020, and TKP-2021-EGA-32 (NKFIH, Hungary). This contribution is based upon work from COST Action CA18202, NECTAR-Network for Equilibria and Chemical Thermodynamics Advanced Research, supported by COST (European Cooperation in Science and Technology). The Portuguese NMR and Mass spectrometry IST-UL are acknowledged for the access to the equipment. This work was also supported by Koc University School of Medicine (KUSOM) and the authors gratefully acknowledge use of the services and facilities of the Koc University Research Center for Translational Medicine (KUTTAM), funded by the Presidency of Turkey, Presidency of Strategy and Budget. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Presidency of Strategy and Budget. GS, VU, EG thank Fondazione di Sardegna (grant FdSGarribba 2017); GS also thank MICINN' Juan de la Cierva program, FJC 2019-039135-I for the financial support. L.P. LF acknowledges financial support from Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) through grants UIDB/04046/2020 and UIDP/04046/2020 to BioISI and research infrastructure NECL-proj. 22096. AB - We report the synthesis and characterization of a group of benzoylhydrazones (L n ) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH 3 , OCH 3 , OH and NH 2 , for L 1-7 , respectively; in L 8 isonicotinohydrazide was used instead of benzylhydrazide). Cu(II) complexes were prepared by reaction of each benzoylhydrazone with Cu(II) acetate. All compounds were characterized by elemental analysis and mass spectrometry as well as by FTIR, UV-visible absorption, NMR or electron paramagnetic resonance spectroscopies. Complexes isolated in the solid state ( 1–8 ) are either formulated as [Cu(HL)acetate] (with L 1 and L 4 ) or as [Cu(L n )] 3 ( n = 2, 3, 5, 6, 7 and 8). Single crystal X-ray diffraction studies were done for L 5 and [Cu(L 5 )] 3 , confirming the trinuclear formulation of several complexes. Proton dissociation constants, lipophilicity and solubility were determined for all free ligands by UV-Vis spectrophotometry in 30% (v/v) DMSO/H 2 O. Formation constants were determined for [Cu(LH)], [Cu(L)] and [Cu(LH −1 )] for L = L 1 , L 5 and L 6 , and also [Cu(LH −2 )] for L = L 6 , and binding modes are proposed, [Cu(L)] predominating at physiological pH. The redox properties of complexes formed with L 1 , L 5 and L 6 are investigated by cyclic voltammetry; the formal redox potentials fall in the range of +377 to +395 mV vs. NHE. The binding of the Cu(II)-complexes to bovine serum albumin was evaluated by fluorescence spectroscopy, showing moderate-to-strong interaction and suggesting formation of a ground state complex. The interaction of L 1 , L 3 , L 5 and L 7 , and of the corresponding complexes with calf thymus DNA was evaluated by thermal denaturation. The antiproliferative activity of all compounds was evaluated in malignant melanoma (A-375) and lung (A-549) cancer cells. The complexes show higher activity than the corresponding free ligand, and most complexes are more active than cisplatin. Compounds 1, 3, 5 , and 8 were selected for additional studies: while these complexes induce reactive oxygen species and double-strand breaks in both cancer cells, their ability to induce cell-death by apoptosis varies. Within the set of compounds tested, 8 emerges as the most promising one, presenting low IC 50 values, and high induction of oxidative stress and DNA damage, which eventually lead to high rates of apoptosis. LA - English DB - MTMT ER - TY - JOUR AU - Sancha, Shirley A. R. AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Ferreira, Maria-José U. TI - Lycorine Carbamate Derivatives for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 3 PG - 22 SN - 1661-6596 DO - 10.3390/ijms24032061 UR - https://m2.mtmt.hu/api/publication/33578997 ID - 33578997 N1 - Funding details: BO/00158/22/5 Funding details: Fundação para a Ciência e a Tecnologia, FCT, PTDC/MED-QUI/30591/2017 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund, ERDF Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, 022161, 2019/2020, SFRH/BD/130348/2017 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding text 1: This research was funded by the Fundação para a Ciência e Tecnologia (FCT), Portugal (projects: PTDC/MED-QUI/30591/2017; Bilateral Portuguese-Hungarian Science & Technology Cooperation FCT/NKFIH, 2019/2020; and PhD grant SFRH/BD/130348/2017). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL, and FCT through PIDDAC). The study was also supported by the Szeged Foundation for Cancer Research (Szegedi Rákkutatásért Alapítvány, Hungary). G.S. was supported by the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences. AB - Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. Aiming at generating a small library of anticancer compounds for overcoming MDR, lycorine (1), a major Amaryllidaceae alkaloid isolated from Pancratium maritimum, was derivatized. Thirty-one new compounds (2–32) were obtained by chemical transformation of the hydroxyl groups of lycorine into mono- and di-carbamates. Compounds 1–32 were evaluated as MDR reversers, through the rhodamine-123 accumulation assay by flow cytometry and chemosensitivity assays, in resistant human colon adenocarcinoma cancer cells (Colo 320), overexpressing P-glycoprotein (P-gp, ABCB1). Significant inhibition of P-gp efflux activity was observed for the di-carbamate derivatives, mainly those containing aromatic substituents, at non-cytotoxic concentrations. Compound 5, bearing a benzyl substituent, and compounds 9 and 25, with phenethyl moieties, were among the most active, exhibiting strong inhibition at 2 µM, being more active than verapamil at 10-fold higher concentration. In drug combination assays, most compounds were able to synergize doxorubicin. Moreover, some derivatives showed a selective antiproliferative effect toward resistant cells, having a collateral sensitivity effect. In the ATPase assay, selected compounds (2, 5, 9, 19, 25, and 26) were shown to behave as inhibitors. LA - English DB - MTMT ER - TY - JOUR AU - Teixeira, Ricardo G. AU - Mészáros, János Péter AU - Matos, Beatriz AU - Côrte-Real, Leonor AU - Xavier, Cristina P.R. AU - Fontrodona, Xavier AU - Garcia, M. Helena AU - Romero, Isabel AU - Spengler, Gabriella AU - Vasconcelos, M. Helena AU - Tomaz, Ana Isabel AU - Enyedy, Éva Anna AU - Valente, Andreia TI - Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 262 PY - 2023 PG - 19 SN - 0223-5234 DO - 10.1016/j.ejmech.2023.115922 UR - https://m2.mtmt.hu/api/publication/34231130 ID - 34231130 N1 - Available online 31 October 2023, 115922; In Press, Journal Pre-proof LA - English DB - MTMT ER - TY - JOUR AU - Wirasisya, Dyke Gita AU - Kincses, Annamária AU - Vidács, Lívia Melinda AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Barta, Anita AU - Mertha, I Gde AU - Hohmann, Judit TI - Indonesian Euphorbiaceae: Ethnobotanical Survey, In Vitro Antibacterial, Antitumour Screening and Phytochemical Analysis of Euphorbia atoto JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 12 PY - 2023 IS - 22 PG - 16 SN - 2223-7747 DO - 10.3390/plants12223836 UR - https://m2.mtmt.hu/api/publication/34328388 ID - 34328388 AB - Indonesia is among the countries with the most significant biodiversity globally. Jamu, the traditional medicine of Indonesia, predominantly uses herbal materials and is an integral component of the Indonesian healthcare system. The present study reviewed the ethnobotanical data of seven Indonesian Euphorbiaceae species, namely Euphorbia atoto, E. hypericifolia, Homalanthus giganteus, Macaranga tanarius, Mallotus mollissimus, M. rufidulus, and Shirakiopsis indica, based on the RISTOJA database and other literature sources. An antimicrobial screening of the plant extracts was performed in 15 microorganisms using the disk diffusion and broth microdilution methods, and the antiproliferative effects were examined in drug-sensitive Colo 205 and resistant Colo 320 cells by the MTT assay. The antimicrobial testing showed a high potency of M. tanarius, H. giganteus, M. rufidulus, S. indica, and E. atoto extracts (MIC = 12.5–500 µg/mL) against different bacteria. In the antitumour screening, remarkable activities (IC50 0.23–2.60 µg/mL) were demonstrated for the extracts of H. giganteus, M. rufidulus, S. indica, and E. atoto against Colo 205 cells. The n-hexane extract of E. atoto, with an IC50 value of 0.24 ± 0.06 µg/mL (Colo 205), was subjected to multistep chromatographic separation, and 24-methylene-cycloartan-3β-ol, jolkinolide E, tetra-tert-butyl-diphenyl ether, α-tocopherol, and β-sitosterol were isolated. LA - English DB - MTMT ER - TY - JOUR AU - Wittmann, Christopher AU - Dömötör, Orsolya AU - Kuznetcova, Irina AU - Spengler, Gabriella AU - Reynisson, Johannes AU - Holder, Lauren AU - Miller, Gavin John AU - Enyedy, Éva Anna AU - Bai, Ruoli AU - Hamel, Ernest AU - Arion, Vladimir TI - Indolo[2,3-e]benzazocines and indolo[2,3-f]benzazonines and their copper(II) complexes as microtubule destabilizing agents JF - JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS J2 - J CHEM SOC DALTON TRANS VL - 52 PY - 2023 IS - 29 SP - 9964 EP - 9982 PG - 19 SN - 1472-7773 DO - 10.1039/D3DT01632C UR - https://m2.mtmt.hu/api/publication/34046103 ID - 34046103 N1 - Institute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, Vienna, A-1090, Austria MTA-SZTE Lendület Functional Metal Complexes Research Group, Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Schools of Chemical and Physical Sciences and Pharmacy and Bioengineering, Keele University, Staffordshire, ST5 5BG, United Kingdom Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Diagnosis and Treatment, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, United States Export Date: 18 September 2023 CODEN: DTARA Correspondence Address: Arion, V.B.; Institute of Inorganic Chemistry, Währinger Strasse 42, Austria; email: vladimir.arion@univie.ac.at Chemicals/CAS: copper, 15158-11-9, 7440-50-8; Antineoplastic Agents; Coordination Complexes; Copper; Heterocyclic Compounds; Ligands; Tubulin Funding details: Austrian Science Fund, FWF, P31293-N37 Funding text 1: This work was supported by the Austrian Science Fund (FWF) via the grant no. P31293-N37. AB - A series of four indolo[2,3-e]benzazocines HL1–HL4 and two indolo[2,3-f]benzazonines HL5–and HL6, as well as their respective copper(II) complexes 1–6 were synthesized and characterized by 1H and 13C NMR spectroscopy, ESI... LA - English DB - MTMT ER - TY - JOUR AU - Yazdani, Morteza AU - Barta, Anita AU - Hetényi, Anasztázia AU - Berkecz, Róbert AU - Spengler, Gabriella AU - Ványolós, Attila AU - Hohmann, Judit TI - Isolation of the Lanostane Triterpenes Pholiols L–S from Pholiota populnea and Evaluation of Their Antiproliferative and Cytotoxic Activities JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 16 PY - 2023 IS - 1 PG - 13 SN - 1424-8247 DO - 10.3390/ph16010104 UR - https://m2.mtmt.hu/api/publication/33552540 ID - 33552540 N1 - Export Date: 25 April 2023 Correspondence Address: Hohmann, J.; Institute of Pharmacognosy, Hungary; email: hohmann.judit@szte.hu LA - English DB - MTMT ER - TY - JOUR AU - Abu Ghazal, Tasneem AU - Schelz, Zsuzsanna AU - Vidács, Lívia Melinda AU - Szemerédi, Nikoletta AU - Veres, Katalin AU - Spengler, Gabriella AU - Hohmann, Judit TI - Antimicrobial, Multidrug Resistance Reversal and Biofilm Formation Inhibitory Effect of Origanum majorana Extracts, Essential Oil and Monoterpenes JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 11 PY - 2022 IS - 11 PG - 14 SN - 2223-7747 DO - 10.3390/plants11111432 UR - https://m2.mtmt.hu/api/publication/32910919 ID - 32910919 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Fund (NKFI) [K135845] Funding text: This research was supported by the National Research, Development and Innovation Fund (NKFI) under grant numbers K135845. AB - Origanum majorana L. is a widely used medicinal plant; its distilled oil and preparations are extensively utilised in the phytotherapy and food industries. The objective of this study is to evaluate the extracts and the essential oil (EO) of Origanum majorana L, and its monoterpenes for antimicrobial, bacterial multidrug resistance reversing, and biofilm formation inhibitory potency. The composition of EO and n-hexane extract was characterized by GC-MS. In the essential oil terpinen-4-ol (24.92%), trans-sabinene hydrate (25.18%), gamma-terpinene (6.48%), cis-sabinene hydrate (5.44%), p-cymene (4.72%), sabinene (4.53%), alpha-terpineol (4.43%), and alpha-terpinene (3.00%) were found as the main constituents while trans-sabinene hydrate (1.43%), and terpinen-4-ol (0.19%) were detected in the n-hexane extract besides a series of hydrocarbons. The antibacterial activity of EO and terpinen-4-ol, alpha-terpinene, and linalool was also assessed against sensitive and drug-resistant S. aureus, and E. coli strains with MIC values of 0.125-0.250% and 30-61 mu M, respectively. In the efflux pump (EP) inhibitory assay, made by the ethidium bromide accumulation method in E. coli ATCC 25922, and AG100 and S. aureus ATCC 25923, and MRSA ATCC 43300 strains, EO exhibited substantial activity, especially in the E. coli ATCC 25922 strain. Among the EO constituents, only sabinene was an EP inhibitor in sensitive Escherichia strain. In the case of S. aureus strains, EO and sabinene hydrate exhibited moderate potency on the drug-resistant phenotype. The antibiofilm effects of the samples were tested by crystal violet staining at sub-MIC concentration. gamma-Terpinene, terpinen-4-ol, sabinene, sabinene hydrate and linalool were found to be effective inhibitors of biofilm formation (inhibition 36-86%) on E. coli ATCC 25922 and S. aureus MRSA ATCC 43300, while EO was ineffective on these strains. In contrast to this, biofilms formed by E. coli AG100 and S. aureus ATCC 25923 were significantly inhibited by the EO; however, it was not affected by any of the monoterpenes. This observation suggests that the antibiofilm effect might be altered by the synergism between the components of the essential oil. LA - English DB - MTMT ER - TY - JOUR AU - Ali, Wesam AU - Garbo, Sabrina AU - Kincses, Annamária AU - Nové, Márta AU - Spengler, Gabriella AU - Di Bello, Elisabetta AU - Honkisz-Orzechowska, Ewelina AU - Karcz, Tadeusz AU - Szymańska, Ewa AU - Żesławska, Ewa AU - Starek, Małgorzata AU - Dąbrowska, Monika AU - Nitek, Wojciech AU - Kucwaj-Brysz, Katarzyna AU - Pyka, Patryk AU - Fioravanti, Rossella AU - Jacob, Claus AU - Battistelli, Cecilia AU - Zwergel, Clemens AU - Handzlik, Jadwiga TI - Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 243 PY - 2022 PG - 19 SN - 0223-5234 DO - 10.1016/j.ejmech.2022.114761 UR - https://m2.mtmt.hu/api/publication/33150816 ID - 33150816 N1 - Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, Kraków, 30-688, Poland Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus B 2.1, Saarbruecken, D-66123, Germany Istituto Pasteur Italia, Fondazione Cenci-Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, 00161, Italy Institute of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy Institute of Biology, Pedagogical University of Krakow, Podchorążych 2, Kraków, 30-084, Poland Department of Inorganic Chemistry, Jagiellonian University, Medical College, Medyczna 9, Kraków, 30-688, Poland Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków, 30-387, Poland Cited By :1 Export Date: 8 February 2023 CODEN: EJMCA Correspondence Address: Zwergel, C.; Department of Drug Chemistry and Technologies, Piazzale Aldo Moro 5, Italy; email: clemens.zwergel@uniroma1.it Correspondence Address: Battistelli, C.; Istituto Pasteur Italia, Viale Regina Elena 324, Italy; email: cecilia.battistelli@uniroma1.it Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Medyczna 9, Kraków, Poland; email: j.handzlik@uj.edu.pl Chemicals/CAS: sulfide, 18496-25-8; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Neoplasm Proteins; Pharmaceutical Preparations; Sulfides; Triazines Funding details: N42/DBS/000196 Funding details: Narodowe Centrum Nauki, NCN, UMO-2018/31/B/NZ7/02160 Funding details: Universität des Saarlandes, WT/2 – LFFP 16/01 Funding details: Regione Lazio, A0375-2020-36597 Funding text 1: All syntheses were financially supported by National Science Centre, Poland Grant No. UMO-2018/31/B/NZ7/02160 , biological studies of T.K. and E.H.O supported by Jagiellonian University project : N42/DBS/000196 . W. A. was financed by Saarland University , “Landesforschungsförderungsprogramm” (Grant No. WT/2 – LFFP 16/01). C. B. was funded by SEED PNR 2021. C.Z. acknowledge Regione Lazio PROGETTI DI GRUPPI DI RICERCA 2020, project ID A0375-2020-36597 and is thankful for the generous funding from FSE REACT-EU within the program PON “Research and Innovation” 2014–2020, Action IV.6 “Contratti di ricerca su tematiche Green” as well as from KOHR Aerospace GmbH. LA - English DB - MTMT ER - TY - JOUR AU - Csuvik, Oszkár AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Szatmári, István TI - Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 17 PG - 17 SN - 1661-6596 DO - 10.3390/ijms23179688 UR - https://m2.mtmt.hu/api/publication/33070315 ID - 33070315 N1 - Funding details: ÚNKP-21-3 SZTE-103 Funding details: TKP-2021-EGA-32 Funding details: Hungarian Scientific Research Fund, OTKA, K-138871 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, BO/00158/22/5 Funding details: Innovációs és Technológiai Minisztérium Funding text 1: The authors’ thanks are due to the Hungarian Research Foundation (OTKA No. K-138871), the Ministry of Human Capacities, Hungary grant, TKP-2021-EGA-32, and the Gedeon Richter Plc. Centenarial Foundation. N.S. was supported by the ÚNKP-21-3 SZTE-103 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund. G.S. was supported by the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences. AB - The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1H,3H)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (mMr) applying formaldehyde and piperidine, but a second paraformaldehyde molecule was incorporated into the Mannich product. The reaction also afforded the formation of bisquinoline derivatives. A new 1H-azeto [1,2-a]quinoline derivative was synthesised in two different ways; namely starting from the aminomethylated product or from the ester-hydrolysed 4HQ. When the aldehyde component was replaced with aromatic aldehydes, Knoevenagel condensation took place affording the formation of the corresponding benzylidene derivatives, with the concomitant generation of bisquinolines. The reactivity of salicylaldehyde and hydroxynaphthaldehydes was tested; under these conditions, partially saturated lactones were formed through spontaneous ring closure. The activity of the derivatives was assessed using doxorubicin-sensitive and -resistant colon adenocarcinoma cell lines and normal human fibroblasts. Some derivatives possessed selective toxicity towards resistant cancer cells compared to doxorubicin-sensitive cancer cells and normal fibroblasts. Cytotoxic activity of the benzylidene derivatives and the corresponding Hammett–Brown substituent were correlated. LA - English DB - MTMT ER - TY - JOUR AU - Dobiasová, Simona AU - Szemerédi, Nikoletta AU - Kučerová, Denisa AU - Koucká, Kamila AU - Václavíková, Radka AU - Gbelcová, Helena AU - Ruml, Tomáš AU - Domínguez-Álvarez, Enrique AU - Spengler, Gabriella AU - Viktorová, Jitka TI - Ketone-selenoesters as potential anticancer and multidrug resistance modulation agents in 2D and 3D ovarian and breast cancer in vitro models JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 16 SN - 2045-2322 DO - 10.1038/s41598-022-10311-y UR - https://m2.mtmt.hu/api/publication/32820325 ID - 32820325 N1 - Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, Prague 6, 166 28, Czech Republic Department of Medical Microbiology, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Toxicogenomics Unit, National Institute of Public Health, Šrobárova 49, Prague, 100 00, Czech Republic Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 1655, Pilsen, 323 00, Czech Republic Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, Bratislava, 811 08, Slovakia Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, Madrid, 28006, Spain Cited By :1 Export Date: 8 February 2023 Correspondence Address: Viktorová, J.; Department of Biochemistry and Microbiology, Technická 3, Czech Republic; email: prokesoj@vscht.cz Correspondence Address: Spengler, G.; Department of Medical Microbiology, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General (IQOG-CSIC), Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; Antineoplastic Agents; Doxorubicin; Ketones Funding details: LTC19007, LTC19020 Funding details: European Cooperation in Science and Technology, COST Funding details: Consejo Superior de Investigaciones Científicas, CSIC, LINKA20285 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: Authors would like to thank Prof. Jan Kovář from the Third Faculty of Medicine, Charles University, Prague for providing both the MCF-7 and MCF-7/PAX cell lines. The study was supported by the projects VISEGRAD FUND, Grant number 22010090, by the mobility project from the Czech Ministry of Education, Youth and Sports INTER-COST, Grant numbers LTC19007 and LTC19020, and by Consejo Superior de Investigaciones Científicas (CSIC, Spain, project LINKA20285). This article is based upon work from COST Action 17104 , supported by COST (European Cooperation in Science and Technology), ( www.cost.eu , accessed on 17 Sept 2021). N.S. was supported by the ÚNKP-21-3 New National Excellence Program of the Ministry of Innovation and Technology from the source of the National Research, Development and Innovation Fund (Hungary). LA - English DB - MTMT ER - TY - JOUR AU - Domínguez-Álvarez, Enrique AU - Rácz, Bálint AU - Marć, Małgorzata Anna AU - Nasim, Muhammad Jawad AU - Szemerédi, Nikoletta AU - Viktorová, Jitka AU - Jacob, Claus AU - Spengler, Gabriella TI - Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents JF - DRUG RESISTANCE UPDATES J2 - DRUG RESIST UPDATE VL - 63 PY - 2022 PG - 24 SN - 1368-7646 DO - 10.1016/j.drup.2022.100844 UR - https://m2.mtmt.hu/api/publication/32832029 ID - 32832029 N1 - Instituto de Química Orgánica General (IQOG), CSIC, Juan de la Cierva 3, Madrid, 28006, Spain Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Saarbruecken, D-66123, Germany Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, Prague 6, 166 28, Czech Republic Cited By :5 Export Date: 8 February 2023 CODEN: DRUPF Correspondence Address: Spengler, G.; Department of Medical Microbiology, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; borneol, 10385-78-1, 507-70-0; ebselen, 60940-34-3; folic acid, 59-30-3, 6484-89-5; galactosamine, 7535-00-4; glutathione disulfide, 27025-41-8; rhenium, 7440-15-5; selenate, 13410-01-0, 14124-68-6; selenite, 14124-67-5; selenocysteine, 3614-08-2; selenomethionine, 1464-42-2, 3211-76-5; tellurium, 13494-80-9; selenium, 7782-49-2; Antineoplastic Agents; Reactive Oxygen Species; Selenium; Tellurium Funding details: LTC19007 Funding details: GINOP-2.3.2–15-2016–00038 Funding details: European Cooperation in Science and Technology, COST, EFOP-3.6.3-VEKOP-16–2017-00009 Funding details: Consejo Superior de Investigaciones Científicas, CSIC, LINKA20285 Funding text 1: The study was supported by the projects SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine and GINOP-2.3.2–15-2016–00038 (Hungary), Agencia Estatal Consejo Superior de Investigaciones Científicas (CSIC, Spain, mobility project LINKA20285). This research was funded by the mobility project from the Czech Ministry of Education, Youth and Sports INTER-COST, grant number LTC19007. This article is based upon work from COST Action 17104 , supported by COST (European Cooperation in Science and Technology, http://www.cost.eu, assessed on 30 December 2021). The study was also supported by two associations from the province of Zamora, Spain: “Asociación Cultural Trevinca” and “Iniciativas Ropelanas”. B.R. was supported by the project EFOP-3.6.3-VEKOP-16–2017-00009 (Hungary). N.S. was supported by the New National Excellence Program (ÚNKP). Funding text 2: The study was supported by the projects SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine and GINOP-2.3.2–15-2016–00038 (Hungary), Agencia Estatal Consejo Superior de Investigaciones Científicas (CSIC, Spain, mobility project LINKA20285 ). This research was funded by the mobility project from the Czech Ministry of Education, Youth and Sports INTER-COST , grant number LTC19007 . This article is based upon work from COST Action 17104 , supported by COST (European Cooperation in Science and Technology, http://www.cost.eu , assessed on 30 December 2021). The study was also supported by two associations from the province of Zamora, Spain: “Asociación Cultural Trevinca” and “Iniciativas Ropelanas”. B.R. was supported by the project EFOP-3.6.3-VEKOP-16–2017-00009 (Hungary). N.S. was supported by the New National Excellence Program (ÚNKP). LA - English DB - MTMT ER - TY - JOUR AU - Dömötör, Orsolya AU - May, Nóra Veronika AU - Gál, Gyula Tamás AU - Spengler, Gabriella AU - Dobrova, Aliona AU - Arion, Vladimir B. AU - Enyedy, Éva Anna TI - Solution Equilibrium Studies on Salicylidene Aminoguanidine Schiff Base Metal Complexes: Impact of the Hybridization with L-Proline on Stability, Redox Activity and Cytotoxicity JF - MOLECULES J2 - MOLECULES VL - 27 PY - 2022 IS - 7 PG - 21 SN - 1420-3049 DO - 10.3390/molecules27072044 UR - https://m2.mtmt.hu/api/publication/32753521 ID - 32753521 N1 - Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Centre for Structural Science, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, Budapest, H-1117, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Institute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, Vienna, A-1090, Austria Cited By :4 Export Date: 7 June 2023 CODEN: MOLEF Correspondence Address: Enyedy, É.A.; MTA-SZTE Lendület Functional Metal Complexes Research Group, Dóm tér 7, Hungary; email: enyedy@chem.u-szeged.hu Chemicals/CAS: aminoguanidine, 1068-42-4, 2582-30-1, 79-17-4; ferric ion, 20074-52-6; ferrous ion, 15438-31-0; proline, 147-85-3, 7005-20-1; Coordination Complexes; Ferric Compounds; Ferrous Compounds; Guanidines; Ligands; pimagedine; Proline; Schiff Bases Funding details: Innovációs és Technológiai Minisztérium Funding details: National Research, Development and Innovation Office, FK124240, K124544, TKP-2021-EGA-32, ÚNKP-21-5-SZTE-546 Funding text 1: Funding: This research was funded by National Research, Development and Innovation Office-NKFIA through projects FK124240, K124544 and TKP-2021-EGA-32, and by the ÚNKP-21-5-SZTE-546 New National Excellence program of the Ministry for Innovation and Technology. LA - English DB - MTMT ER - TY - CONF AU - Felegyi, Kristóf AU - Garádi, Zsófia AU - Rácz, Bálint AU - Boldizsár, Imre AU - Papp, Viktor AU - Spengler, Gabriella AU - Béni, Szabolcs AU - Ványolós, Attila ED - Rédei, Dóra TI - Triterpén vegyületek a tölgyfa-kérgestaplóból (Buglossoporus quercinus): izolálás, szerkezetmeghatározás és biológiai aktivitás T2 - Fiatal Gyógynövénykutatók Fóruma: a Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztályának rendezvénye PB - Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztálya C1 - Szeged PY - 2022 SP - 22 EP - 22 PG - 1 DO - 10.14232/fgykf.2022.a14 UR - https://m2.mtmt.hu/api/publication/32912155 ID - 32912155 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Hammadi, Reham AU - Kúsz, Norbert AU - Dávid, Csilla Zsuzsanna AU - Mwangi, Peter Waweru AU - Berkecz, Róbert AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Hohmann, Judit AU - Vasas, Andrea TI - Polyoxypregnane Ester Derivatives and Lignans from Euphorbia gossypina var. coccinea Pax. JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 11 PY - 2022 IS - 10 PG - 15 SN - 2223-7747 DO - 10.3390/plants11101299 UR - https://m2.mtmt.hu/api/publication/32824304 ID - 32824304 N1 - Export Date: 9 August 2022 LA - English DB - MTMT ER - TY - JOUR AU - Hegedűs, Dóra AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Szatmári, István TI - Application of partially aromatic ortho-quionone-methides for the synthesis of novel naphthoxazines with improved antibacterial activity JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 237 PY - 2022 PG - 8 SN - 0223-5234 DO - 10.1016/j.ejmech.2022.114391 UR - https://m2.mtmt.hu/api/publication/32790854 ID - 32790854 N1 - Institute of Pharmaceutical Chemistry and Research Group for Stereochemistry, Hungarian Academy of Sciences, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Institute of Pharmaceutical Chemistry, University of Szeged, Interdisciplinary Excellence Center, Eötvös u. 6, Szeged, H-6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Cited By :1 Export Date: 6 April 2023 CODEN: EJMCA Correspondence Address: Szatmári, I.; Institute of Pharmaceutical Chemistry and Research Group for Stereochemistry, Eötvös u. 6, Hungary; email: szatmari.istvan@szte.hu Chemicals/CAS: reserpine, 50-55-5, 8001-95-4; amino acid, 65072-01-7; imine, 13774-92-0; Amino Acids; Anti-Bacterial Agents; Imines Funding details: EFOP-3.6.3-VEKOP-16-2017-00009, TKP-2021-EGA-32 Funding details: Hungarian Scientific Research Fund, OTKA, K-138871 Funding text 1: The authors' thanks are due to the Hungarian Research Foundation (OTKA No. K-138871 ) and the Ministry of Human Capacities , Hungary grant, TKP-2021-EGA-32 . N.S. was supported by the project EFOP-3.6.3-VEKOP-16-2017-00009 (Hungary). Funding text 2: To start our investigation on the formation of partially aromatic ortho-quinone methides (o-QM) via [4 + 2] cycloaddition, 2-naphthol-substituted glycine precursor 3 was synthesised. Accordingly, 2-naphthol (1) and morpholine (2) were reacted in the presence of ethyl glyoxylate as an aldehyde component. In one of our previous works, it was found, that hydroxynaphthyl-substituted glycine derivatives can be generated from 2- or 1-naphthol, benzyl carbamate and glyoxylic acid via the modified Mannich reaction. We pointed out that in the presence of p-toluenesulfonic acid the reaction yield increased. Furthermore, the absolute configuration of the enantiomers was determined by circular dichroism (CD) analysis supported by TDDFT calculations [21]. Moreover, in the case of glycine ester analogues substituted with 2- or 1-naphthol, the separation of enantiomers was achieved via HPLC measurements and a systematic influence was observed between the character of the ester function and HPLC parameters [22]. In order to form functionalised aminonaphthol derivatives, morpholine (2) as stable cyclic secondary amine was selected as substrate in the reactions. The crude reaction mixtures formed under microwave irradiation in 30 min at 80 ?C and in 30 min at 100 ?C in toluene were examined by 1H NMR measurements. It is interesting to note that using conventional heating, the formation of the desired product 3 could not be detected (Scheme 1).The authors' thanks are due to the Hungarian Research Foundation (OTKA No. K-138871) and the Ministry of Human Capacities, Hungary grant, TKP-2021-EGA-32. N.S. was supported by the project EFOP-3.6.3-VEKOP-16-2017-00009 (Hungary). LA - English DB - MTMT ER - TY - JOUR AU - Jesus, Ana AU - Durães, Fernando AU - Szemerédi, Nikoletta AU - Freitas-Silva, Joana AU - da Costa, Paulo Martins AU - Pinto, Eugénia AU - Pinto, Madalena AU - Spengler, Gabriella AU - Sousa, Emília AU - Cidade, Honorina TI - BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections JF - MARINE DRUGS J2 - MAR DRUGS VL - 20 PY - 2022 IS - 5 PG - 21 SN - 1660-3397 DO - 10.3390/md20050315 UR - https://m2.mtmt.hu/api/publication/32820336 ID - 32820336 N1 - Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal CIIMAR—Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Avenida General Norton de Matos, Matosinhos, 4450-208, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary ICBAS—Institute of Biomedical Sciences Abel Salazar, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Export Date: 5 November 2022 CODEN: MDARE Correspondence Address: Sousa, E.; Laboratory of Organic and Pharmaceutical Chemistry, Rua Jorge Viterbo Ferreira 228, Portugal; email: esousa@ff.up.pt Correspondence Address: Cidade, H.; Laboratory of Organic and Pharmaceutical Chemistry, Rua Jorge Viterbo Ferreira 228, Portugal; email: hcidade@ff.up.pt LA - English DB - MTMT ER - TY - JOUR AU - Kerekes, Diána AU - Horváth, Attila AU - Kúsz, Norbert AU - Borcsa, Botond Lajos AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Csupor, Dezső TI - Coumarins, furocoumarins and limonoids of Citrus trifoliata and their effects on human colon adenocarcinoma cell lines JF - HELIYON J2 - HELIYON VL - 8 PY - 2022 IS - 9 PG - 7 SN - 2405-8440 DO - 10.1016/j.heliyon.2022.e10453 UR - https://m2.mtmt.hu/api/publication/33135629 ID - 33135629 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Balázs AU - Szemerédi, Nikoletta AU - Kúsz, Norbert AU - Kiss, Tivadar AU - Csupor-Löffler, Boglárka AU - Tsai, Y-C AU - Spengler, Gabriella AU - Csupor, Dezső TI - Antiproliferative sesquiterpene lactones from Ambrosia artemisiifolia L JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 88 PY - 2022 IS - 15 SP - 1533 EP - 1533 PG - 1 SN - 0032-0943 DO - 10.1055/s-0042-1759242 UR - https://m2.mtmt.hu/api/publication/33684363 ID - 33684363 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Balázs AU - Szemerédi, Nikoletta AU - Kúsz, Norbert AU - Kiss, Tivadar AU - Csupor-Löffler, Boglárka AU - Tsai, Yu-Chi AU - Rácz, Bálint AU - Spengler, Gabriella AU - Csupor, Dezső TI - Antiproliferative and cytotoxic effects of sesquiterpene lactones isolated from Ambrosia artemisiifolia on human adenocarcinoma and normal cell lines. JF - PHARMACEUTICAL BIOLOGY J2 - PHARM BIOL VL - 60 PY - 2022 IS - 1 SP - 1511 EP - 1519 PG - 9 SN - 1388-0209 DO - 10.1080/13880209.2022.2103574 UR - https://m2.mtmt.hu/api/publication/33049439 ID - 33049439 AB - Ambrosia artemisiifolia L. (Asteraceae) contains sesquiterpene lactones as characteristic secondary metabolites. Many of these compounds exert antiproliferative and cytotoxic effects.To isolate the sesquiterpene lactones from the aerial part of A. artemisiifolia and to elucidate their cytotoxic, antiproliferative and antibacterial effects.The compounds were identified by one-dimensional (1D) and 2D NMR, HR-MS spectroscopy from the methanol extract. Isolated compounds were investigated for their cytotoxic and antiproliferative effects on human colonic adenocarcinoma cell lines and human embryonal lung fibroblast cell line using MTT assay. The selectivity of the sesquiterpenes was calculated towards the normal cell line. To check the effect of drug interactions between compounds and doxorubicin, multidrug-resistant Colo 320 cells were used.A new seco-psilostachyinolide derivative, 1,10-dihydro-1'-noraltamisin, and seven known compounds were isolated from the methanol extract. Acetoxydihydrodamsin had the most potent cytotoxic effect on sensitive (Colo205) cell line (IC50 = 7.64 µM), also the strongest antiproliferative effect on Colo205 (IC50 = 5.14 µM) and Colo320 (IC50 = 3.67 µM) cell lines. 1'-Noraltamisin (IC50 = 8.78 µM) and psilostachyin (IC50 = 5.29 µM) showed significant antiproliferative effects on the multidrug-resistant Colo320 cell line and had moderate selectivity against human embryonal lung fibroblast cell line. Psilostachyin C exhibited cytotoxic effects on Colo205 cells (IC50 = 26.60 µM). None of the isolated compounds inhibited ABCB1 efflux pump (EP; P-glycoprotein) or the bacterial EPs.Acetoxydihydrodamsin, 1'-noraltamisin, and psilostachyin showed the most remarkable cytotoxic and antiproliferative activity on tumour cell lines and exerted selectivity towards MRC-5 cell line. LA - English DB - MTMT ER - TY - JOUR AU - Kreutzer, David AU - Gehrmann, Robin AU - Kincses, Annamária AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Molnár, József AU - Hilgeroth, Andreas TI - Discovery of a novel class of small-molecule antibacterial agents against Staphylococcus aureus JF - FUTURE MEDICINAL CHEMISTRY J2 - FUTURE MED CHEM VL - 14 PY - 2022 IS - 5 SP - 299 EP - 305 PG - 7 SN - 1756-8919 DO - 10.4155/fmc-2021-0272 UR - https://m2.mtmt.hu/api/publication/32554878 ID - 32554878 N1 - Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Halle, 06120, Germany Department of Medical Microbiology, University of Szeged6720, Hungary Export Date: 25 January 2023 Chemicals/CAS: tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; acridine derivative, 34708-10-6; Acridines; Anti-Bacterial Agents; Small Molecule Libraries LA - English DB - MTMT ER - TY - JOUR AU - Magyari, Józef AU - Barta Holló, Berta AU - Rodić, Marko V. AU - Jovanović, Ljiljana S. AU - Mészáros Szécsényi, Katalin AU - Ferenc, Wiesława AU - Osypiuk, Dariusz AU - Mosolygó, Tímea AU - Kincses, Annamária AU - Spengler, Gabriella TI - Synthesis, characterization, thermal properties and biological activity of diazine-ring containing hydrazones and their metal complexes JF - JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY J2 - J THERM ANAL CALORIM VL - 147 PY - 2022 IS - 1 SP - 229 EP - 242 PG - 14 SN - 1388-6150 DO - 10.1007/s10973-020-10194-z UR - https://m2.mtmt.hu/api/publication/31605492 ID - 31605492 N1 - Funding Agency and Grant Number: Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2020-14/200125]; University of Szeged [GINOP-2.3.2-15-2016-00038] Funding text: This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Grant No. 451-03-68/2020-14/200125). The study was supported by the project GINOP-2.3.2-15-2016-00038 of the University of Szeged. LA - English DB - MTMT ER - TY - JOUR AU - Maia, Miguel AU - Durães, Fernando AU - Resende, Diana I. S. P. AU - Szemerédi, Nikoletta AU - Gales, Luís AU - Martins-da-Costa, Paulo AU - Pinto, Madalena AU - Spengler, Gabriella AU - Sousa, Emília TI - Xanthene Derivatives Targeting Bacterial Efflux Pumps, Quorum-Sensing, and Biofilm Formation JF - DRUGS AND DRUG CANDIDATES J2 - DRUGS DRUG CANDIDATES VL - 1 PY - 2022 IS - 1 SP - 29 EP - 42 PG - 14 SN - 2813-2998 DO - 10.3390/ddc1010004 UR - https://m2.mtmt.hu/api/publication/33727591 ID - 33727591 AB - The rise of multidrug resistance (MDR) bacteria in nosocomial and health-care institutions is widespread and is currently recognized as a major medical challenge. Mechanisms of bacterial resistance, namely, quorum sensing (QS), biofilm formation, and efflux pumps, have been identified as critical biological processes in MDR bacteria. Following previous reports on the activity of phenothiazines against mechanisms of bacterial resistance, in this work we focus on the synthesis of xanthene derivatives aiming to discover phenothiazine bioisosteres with improved activity. Four compounds were obtained from the conjugation of xanthydrol with sulfonamides and aniline and were fully characterized. Their antibacterial activity was assessed considering their minimum inhibitory concentration (MIC) against Gram-positive and Gram-negative strains, efflux pump inhibition, influence on biofilm formation and quorum-sensing (QS) inhibition. It was observed that the MIC of all the tested compounds was above 64 µg/mL The four 9-xanthenyl derivatives obtained, particularly the xanthene sulfonamide derivatives 3b and 3c, showed promising results on QS inhibition with a reduction of pigment production of 48 and 41 mm, and on biofilm formation with a reduction of 78 and 79%, respectively. LA - English DB - MTMT ER - TY - JOUR AU - Marć, Małgorzata Anna AU - Domínguez-Álvarez, Enrique AU - Latacz, Gniewomir AU - Doroz-Płonka, Agata AU - Sanmartín, Carmen AU - Spengler, Gabriella AU - Handzlik, Jadwiga TI - Pharmaceutical and Safety Profile Evaluation of Novel Selenocompounds with Noteworthy Anticancer Activity JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 2 PG - 25 SN - 1999-4923 DO - 10.3390/pharmaceutics14020367 UR - https://m2.mtmt.hu/api/publication/32682935 ID - 32682935 N1 - Funding Agency and Grant Number: Jagiellonian University Medical College, Faculty of Pharmacy [K/DSC/003824, N42/DBS/000196]; Consejo Superior de Investigaciones Cientificas (CSIC, Spain) [LINKA20285]; Asociacion Cultural Trevinca (Spain) [CA17104, SZTE AOK-KKA 2018/270-62-2]; COST Action STRATAGEM [CA17104]; University of Szeged, Faculty of Medicine [SZTE AOK-KKA 2018/270-62-2] Funding text: This research was funded by statutory projects K/DSC/003824, N42/DBS/000196 (Jagiellonian University Medical College, Faculty of Pharmacy), Consejo Superior de Investigaciones Cientificas (CSIC, Spain, project LINKA20285), Asociacion Cultural Trevinca (Spain) and by COST Action CA17104 STRATAGEM, SZTE AOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine and GINOP-2.3.2-15-2016-00038 (Hungary). LA - English DB - MTMT ER - TY - JOUR AU - Moreira, Joana AU - Durães, Fernando AU - Freitas-Silva, Joana AU - Szemerédi, Nikoletta AU - Resende, Diana I.S.P. AU - Pinto, Eugenia AU - da Costa, Paulo Martins AU - Pinto, Madalena AU - Spengler, Gabriella AU - Cidade, Honorina AU - Sousa, Emília TI - New diarylpentanoids and chalcones as potential antimicrobial adjuvants JF - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS J2 - BIOORG MED CHEM LETT VL - 67 PY - 2022 PG - 6 SN - 0960-894X DO - 10.1016/j.bmcl.2022.128743 UR - https://m2.mtmt.hu/api/publication/32845488 ID - 32845488 N1 - Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, Matosinhos, 4450-208, Portugal ICBAS – Institute of Biomedical Sciences Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Hungary Laboratory of Microbiology, Department of Biological Sciences, FFUP – Faculty of Pharmacy, University of Porto, Porto, Portugal Cited By :4 Export Date: 9 June 2023 CODEN: BMCLE Correspondence Address: Cidade, H.; Laboratory of Organic and Pharmaceutical Chemistry, Rua de Jorge Viterbo Ferreira, 228, Portugal; email: hcidade@ff.up.pt Chemicals/CAS: chalcone, 94-41-7; Anti-Bacterial Agents; Chalcone; Chalcones Funding details: CHIRALSINTESE_APSFCT_IINFACTS_2021, NORTE-01-0145-FEDER-000040 Funding details: European Commission, EC Funding details: Fundação para a Ciência e a Tecnologia, FCT, POCI-01–0145-FEDER-028736, PTDC/CTA-AMB/0853/2021, PTDC/SAU-PUB/28736/2017, UIDP/04423/2020 Funding details: European Regional Development Fund, ERDF, SFRH/BD/135852/2018, SFRH/BD/144681/2019 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding text 1: This research was supported by national funds through FCT (Foundation for Science and Technology) within the scope of UIDB/04423/2020, UIDP/04423/2020 (Group of Natural Products and Medicinal Chemistry-CIIMAR), and under the projects PTDC/SAU-PUB/28736/2017 (reference POCI-01–0145-FEDER-028736), and PTDC/CTA-AMB/0853/2021 co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds supported by NORTE2020, through ERDF, and CHIRALSINTESE_APSFCT_IINFACTS_2021. This work was also funded by the structured program of R&D&I ATLANTIDA-Platform for the monitoring of the North Atlantic Ocean and tools for the sustainable exploitation of the marine resources (reference NORTE-01-0145-FEDER-000040), supported by the North Portugal Regional Operational Programme (NORTE2020), through the European Regional Development Fund (ERDF). Joana Moreira and Fernando Durães acknowledge their PhD grants (SFRH/BD/135852/2018 and SFRH/BD/144681/2019, respectively). The authors thank Sara Cravo, Gisela Adriano and Gábor Tóth for all the technical and scientific support. Funding text 2: This research was supported by national funds through FCT (Foundation for Science and Technology) within the scope of UIDB/04423/2020, UIDP/04423/2020 (Group of Natural Products and Medicinal Chemistry-CIIMAR), and under the projects PTDC/SAU-PUB/28736/2017 (reference POCI-01–0145-FEDER-028736), and PTDC/CTA-AMB/0853/2021 co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds supported by NORTE2020, through ERDF, and CHIRALSINTESE_APSFCT_IINFACTS_2021. This work was also funded by the structured program of R&D&I ATLANTIDA-Platform for the monitoring of the North Atlantic Ocean and tools for the sustainable exploitation of the marine resources (reference NORTE-01-0145-FEDER-000040), supported by the North Portugal Regional Operational Programme (NORTE2020), through the European Regional Development Fund (ERDF). Joana Moreira and Fernando Durães acknowledge their PhD grants (SFRH/BD/135852/2018 and SFRH/BD/144681/2019, respectively). The authors thank Sara Cravo, Gisela Adriano and Gábor Tóth for all the technical and scientific support. LA - English DB - MTMT ER - TY - JOUR AU - Mosolygó, Tímea AU - Laczi, Krisztián AU - Spengler, Gabriella AU - Burián, Katalin TI - A Practical Approach for Quantitative Polymerase Chain Reaction, the Gold Standard in Microbiological Diagnosis JF - SCI J2 - SCI VL - 4 PY - 2022 IS - 1 PG - 10 SN - 2413-4155 DO - 10.3390/sci4010004 UR - https://m2.mtmt.hu/api/publication/32609648 ID - 32609648 N1 - The research was funded by the Pedagogy Research Program of the Hungarian Academy of Sciences (2016–2020). LA - English DB - MTMT ER - TY - JOUR AU - Neves, Ana Rita AU - Durães, Fernando AU - Freitas-Silva, Joana AU - Szemerédi, Nikoletta AU - Martins-da-Costa, Paulo AU - Pinto, Eugénia AU - Correia-da-Silva, Marta AU - Spengler, Gabriella AU - Sousa, Emília TI - Derivatives of Trimethoxybenzoic Acid and Gallic Acid as Potential Efflux Pump Inhibitors: In Silico and In Vitro Studies JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 22 PG - 15 SN - 1661-6596 DO - 10.3390/ijms232214468 UR - https://m2.mtmt.hu/api/publication/33288701 ID - 33288701 N1 - Laboratory of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), University of Porto, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, Matosinhos, 4450-208, Portugal ICBAS—Institute of Biomedical Sciences Abel Salazar, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Export Date: 7 February 2023 Correspondence Address: Correia-da-Silva, M.; Laboratory of Organic and Pharmaceutical Chemistry, Rua de Jorge Viterbo Ferreira 228, Portugal; email: m_correiadasilva@ff.up.pt Correspondence Address: Sousa, E.; Laboratory of Organic and Pharmaceutical Chemistry, Rua de Jorge Viterbo Ferreira 228, Portugal; email: esousa@ff.up.pt Chemicals/CAS: gallic acid, 149-91-7; Anti-Bacterial Agents; Bacterial Proteins; Gallic Acid Funding details: European Commission, EC Funding details: Fundação para a Ciência e a Tecnologia, FCT, SFRH/BD/114856/2016, SFRH/BD/144681/2019, UIDP/04423/2020 Funding details: European Regional Development Fund, ERDF, NORTE-01-0145-FEDER-000040 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding details: Centro Interdisciplinar de Investigação Marinha e Ambiental, CIIMAR, EXPL/CTA-AMB/0810/2021, POCI-01–0145-FEDER-028736, PTDC/CTA-AMB/0853/2021, PTDC/SAU-PUB/28736/2017 Funding text 1: The acrA gene inactivated mutant Salmonella enterica serovar Typhimurium SL1344 was provided by Jessica Blair, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, UK. The methicillin and ofloxacin-resistant Staphylococcus aureus 272123 clinical isolates were provided by Leonard Amaral, Institute of Hygiene and Tropical Medicine, Lisbon, Portugal. The bacteria used for the QS assay were kindly provided by Ernő Szegedi, Institute of Viticulture and Enology, National Agricultural Research Center, Badacsonytomaj, Hungary. The authors thank Sara Cravo, Gisela Adriano, and Gabor Tóth for the technical support. A.R.N. and F.D. acknowledge FCT for their Ph.D. grants (SFRH/BD/114856/2016 and SFRH/BD/144681/2019, respectively). Funding text 2: This research was supported by national funds through FCT (Foundation for Science and Technology) within the scope of UIDB/04423/2020, UIDP/04423/2020 (CIIMAR), and under the projects PTDC/SAU-PUB/28736/2017 (reference POCI-01–0145-FEDER-028736), PTDC/CTA-AMB/0853/2021 and EXPL/CTA-AMB/0810/2021 co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds and structured program of R&D&I ATLANTIDA (NORTE-01-0145-FEDER-000040), supported by NORTE2020, through ERDF. AB - The overexpression of efflux pumps is one of the strategies used by bacteria to resist antibiotics and could be targeted to circumvent the antibiotic crisis. In this work, a series of trimethoxybenzoic acid derivatives previously described as antifouling compounds was explored for potential antimicrobial activity and efflux pump (EP) inhibition. First, docking studies on the acridine resistance proteins A and B coupled to the outer membrane channel TolC (AcrAB-TolC) efflux system and a homology model of the quinolone resistance protein NorA EP were performed on 11 potential bioactive trimethoxybenzoic acid and gallic acid derivatives. The synthesis of one new trimethoxybenzoic acid derivative (derivative 13) was accomplished. To investigate the potential of this series of 11 derivatives as antimicrobial agents, and in reverting drug resistance, the minimum inhibitory concentration was determined on several strains (bacteria and fungi), and synergy with antibiotics and EP inhibition were investigated. Derivative 10 showed antibacterial activity against the studied strains, derivatives 5 and 6 showed the ability to inhibit EPs in the acrA gene inactivated mutant Salmonella enterica serovar Typhimurium SL1344, and 6 also inhibited EPs in Staphylococcus aureus 272123. Structure-activity relationships highlighted trimethoxybenzoic acid as important for EP inhibitory activity. Although further studies are necessary, these results show the potential of simple trimethoxybenzoic acid derivatives as a source of feasible EP inhibitors. LA - English DB - MTMT ER - TY - JOUR AU - Pereira, Daniela AU - Durães, Fernando AU - Szemerédi, Nikoletta AU - Freitas-da-Silva, Joana AU - Pinto, Eugénia AU - Martins-da-Costa, Paulo AU - Pinto, Madalena AU - Correia-da-Silva, Marta AU - Spengler, Gabriella AU - Sousa, Emília AU - Cidade, Honorina TI - New Chalcone–Triazole Hybrids with Promising Antimicrobial Activity in Multidrug Resistance Strains JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 22 PG - 18 SN - 1661-6596 DO - 10.3390/ijms232214291 UR - https://m2.mtmt.hu/api/publication/33288735 ID - 33288735 N1 - Funding details: BO/00158/22/5, CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019, CHIRALSINTESE_APSFCT_IINFACTS _2021, SFRH/BD/144681/2019, SFRH/BD/147207/2019 Funding details: European Commission, EC Funding details: Fundação para a Ciência e a Tecnologia, FCT, UIDP/04423/2020 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Regional Development Fund, ERDF, NORTE-01-0145-FEDER-000040 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding details: Centro Interdisciplinar de Investigação Marinha e Ambiental, CIIMAR, EXPL/CTA-AMB/0810/2021, PTDC/CTA-AMB/0853/2021, PTDC/SAU-PUB/28736/2017 Funding text 1: This research was funded by national funds through FCT-Foundation for Science and Technology within the scope of UIDB/04423/2020 and UIDP/04423/2020 (CIIMAR) and under projects PTDC/SAU-PUB/28736/2017, EXPL/CTA-AMB/0810/2021, and PTDC/CTA-AMB/0853/2021, co-financed by COMPETE 2020, Portugal 2020, and the European Union through the ERDF, and by FCT through national funds, and by the structured program of R&D&I ATLANTIDA (reference NORTE-01-0145-FEDER-000040), supported by the North Portugal Regional Operational Programme (NORTE2020), through the ERDF. This research was also supported by IINFACTS, grant number CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019 and CHIRALSINTESE_APSFCT_IINFACTS _2021. Daniela Pereira and Fernando Durães acknowledge FCT for their PhD grants (SFRH/BD/147207/2019 and SFRH/BD/144681/2019, respectively). Gabriella Spengler was supported by the János Bolyai Research Scholarship (BO/00158/22/5) of the Hungarian Academy of Sciences. AB - Resistance to antibiotics is an emerging problem worldwide, which leads to an increase in morbidity and mortality rates. Several mechanisms are attributed to bacterial resistance, overexpression of efflux pumps being one of the most prominent. As an attempt to develop new effective antimicrobial drugs, which could be able to act against resistant bacterial strains and considering the antimicrobial potential of flavonoids and triazolyl flavonoid derivatives, in particular chalcones, a small library of chalcone derivatives was synthesized and evaluated for its potential to act as antimicrobials and/or adjuvants in combination with antibiotics towards resistant bacteria. Although only compound 7 was able to act as antibacterial, compounds 1, 2, 4, 5, 7, and 9 revealed to be able to potentiate the activity of antibiotics in resistant bacteria. Moreover, five compounds (3, 5–8) demonstrated to be effective inhibitors of efflux pumps in Salmonella enterica serovar Typhimurium SL1344, and four compounds (1, 3, 7, and 10) showed higher ability than reserpine to inhibit biofilm formation of resistant Staphylococcus aureus 272123. Together, our results showed the potential of these compounds regarding reversion of bacterial resistance. LA - English DB - MTMT ER - TY - JOUR AU - Petrasheuskaya, Tatsiana AU - Kovács, Ferenc AU - Spengler, Gabriella AU - May, Nóra Veronika AU - Nagyné Frank, Éva AU - Enyedy, Éva Anna TI - A comparative study on the complex formation of 2-aminoestradiol and 2-aminophenol with divalent metal ions: solution chemistry and anticancer activity JF - JOURNAL OF MOLECULAR STRUCTURE J2 - J MOL STRUCT VL - 1261 PY - 2022 PG - 15 SN - 0022-2860 DO - 10.1016/j.molstruc.2022.132858 UR - https://m2.mtmt.hu/api/publication/32747057 ID - 32747057 N1 - Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged, H-6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Centre for Structural Science, Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary Cited By :2 Export Date: 9 June 2023 CODEN: JMOSB Correspondence Address: Enyedy, É.A.; Department of Inorganic and Analytical Chemistry, Dóm tér 7, Hungary; email: enyedy@chem.u-szeged.hu Funding details: FK 124240, TKP-2021-EGA-32 Funding text 1: This work was supported by National Research, Development and Innovation Fund of Hungary [FK 124240 and TKP-2021-EGA-32]. LA - English DB - MTMT ER - TY - CONF AU - Pósa, Vivien AU - May, V. Nóra AU - Spengler, Gabriella AU - Pósa, Szonja AU - Tóth, Szilárd AU - Szakács, Gergely AU - Ugrai, Imre AU - Szatmári, István AU - Nagy, Petra AU - Enyedy, Éva Anna ED - Demetrio, Milea ED - Enrique, García-España Monsonís ED - Mª, Paz Clares García TI - Investigation of the interaction of a water-soluble 8-hydroxyquinoline amino acid hybrid with essential metal ions T2 - Acta of the International Symposia on Thermodynamics of Metal Complexes T3 - ISMEC GROUP SERIES, ISSN 2239-2459 ; 11. PY - 2022 PG - 2 UR - https://m2.mtmt.hu/api/publication/33661605 ID - 33661605 LA - English DB - MTMT ER - TY - JOUR AU - Pósa, Vivien AU - Hajdu, Bálint AU - Tóth, Gábor AU - Dömötör, Orsolya AU - Kowol, Christian R. AU - Keppler, Bernhard K. AU - Spengler, Gabriella AU - Gyurcsik, Béla AU - Enyedy, Éva Anna TI - The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity JF - JOURNAL OF INORGANIC BIOCHEMISTRY J2 - J INORG BIOCHEM VL - 231 PY - 2022 PG - 13 SN - 0162-0134 DO - 10.1016/j.jinorgbio.2022.111786 UR - https://m2.mtmt.hu/api/publication/32729344 ID - 32729344 N1 - MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str. 42, Vienna, A-1090, Austria Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, H-6725, Hungary Cited By :10 Export Date: 9 June 2023 CODEN: JIBID Correspondence Address: Enyedy, É.A.; MTA-SZTE Lendület Functional Metal Complexes Research Group, Dóm tér 7, Hungary; email: enyedy@chem.u-szeged.hu Chemicals/CAS: copper, 15158-11-9, 7440-50-8; DNA topoisomerase (ATP hydrolysing); glutathione, 70-18-8; iron, 14093-02-8, 53858-86-9, 7439-89-6; proton, 12408-02-5, 12586-59-3; ferric ion, 20074-52-6; Antineoplastic Agents; Coordination Complexes; Copper; Ferric Compounds; Semicarbazones Tradenames: Cary 8454, Agilent Manufacturers: Agilent Funding details: 2019-2.1.11-TÉT-2019-00003 Funding details: FK 124240 Funding details: ÚNKP-21-3-SZTE-455, ÚNKP-21-5-SZTE-546 Funding details: Austrian Science Fund, FWF, P31923 Funding text 1: This work was supported by National Research, Development and Innovation Fund of Hungary through projects FK 124240 , the New National Excellence Program Ministry of Human Capacities through the grants ÚNKP-21-5-SZTE-546 (to OD) and ÚNKP-21-3-SZTE-455 (to VP) , the Austrian-Hungarian Scientific & Technological Cooperation 2019-2.1.11-TÉT-2019-00003 , the bilateral OeAD project HU 02/2020 and the Austrian Science Fund (FWF) grant P31923 (to CK) for financial support. The support of the „Lendület” Programme (ELKH, LP2019-6/2019 ) is also acknowledged (EAE). LA - English DB - MTMT ER - TY - GEN AU - Rácz, Bálint AU - Kincses, Annamária AU - Szemerédi, Nikoletta AU - Bo Young, Huh AU - Borbély, Bence AU - Mosolygó, Tímea AU - Spengler, Gabriella TI - Targeting bacteria and their virulence with phenothiazine-type antipsychotics CY - 32nd ECCMID PY - 2022 UR - https://m2.mtmt.hu/api/publication/32845756 ID - 32845756 LA - English DB - MTMT ER - TY - JOUR AU - Saidu, Muhammad Bello AU - Kúsz, Norbert AU - Berkecz, Róbert AU - Rácz, Bálint AU - Spengler, Gabriella AU - Hohmann, Judit AU - Rédei, Dóra TI - Ingol, ent-atisane, and stachane-type diterpenoids from Euphorbia deightonii with multidrug resistance reversing activity JF - PHYTOCHEMISTRY J2 - PHYTOCHEMISTRY VL - 204 PY - 2022 PG - 9 SN - 0031-9422 DO - 10.1016/j.phytochem.2022.113344 UR - https://m2.mtmt.hu/api/publication/33049861 ID - 33049861 N1 - Funding: This work was supported by the Economic Development and Innovation Operative Programme [GINOP-2.3.2-15-2016-00012]. M.B.S. was supported by the Stipendium Hungaricum scholarship program AB - Nine previously undescribed ingol-type diterpenoid polyesters with eighteen known ingol esters, two ent-atisane, and one stachane diterpenoid were isolated from the methanol extract of Euphorbia deightonii Croizat. The structures were established by extensive spectroscopic analysis involving 1D (1H, 13C J-modulation) and 2D NMR experiments, HRESIMS measurements, and the comparison of the spectroscopic data with reported literature values. The cytotoxic concentrations of 13 isolated compounds were determined, and the compounds were investigated for multidrug resistance modulating activity on an L5178 mouse lymphoma cell line using a rho-damin 123 accumulation assay. Six ingol esters demonstrated the significant inhibition of P-glycoprotein, while the two ent-atisane diterpenoids were found to be inactive. The measured activities allowed to establish some structure-activity relationships. Notably, lower and higher-type diterpenoids simultaneously occurred in E. deightonii. LA - English DB - MTMT ER - TY - JOUR AU - Silva, Cristina Duarte AU - Ramalhete, Cátia AU - Spengler, Gabriella AU - Mulhovo, Silva AU - Molnár, József AU - Ferreira, Maria-José U. TI - Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells JF - PHYTOCHEMISTRY J2 - PHYTOCHEMISTRY VL - 203 PY - 2022 PG - 9 SN - 0031-9422 DO - 10.1016/j.phytochem.2022.113354 UR - https://m2.mtmt.hu/api/publication/33077788 ID - 33077788 N1 - Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon, 1649-003, Portugal ATLÂNTICA – Instituto Universitário, Fábrica da Pólvora de Barcarena, Barcarena, Oeiras, 2730-036, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Semmelweis Utca 6, Szeged, 6725, Hungary Centro de Estudos Moçambicanos e de Etnociências, Faculdade de Ciências e Matemática, Universidade Pedagógica, Maputo, 21402161, Mozambique Cited By :1 Export Date: 19 January 2023 CODEN: PYTCA Correspondence Address: Ferreira, M.-J.U.; Research Institute for Medicines (iMed.ULisboa), Av. Prof. Gama Pinto, Portugal; email: mjuferreira@ff.ulisboa.pt Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; methanol, 67-56-1; verapamil, 152-11-4, 52-53-9; ABCB1 protein, human; ATP Binding Cassette Transporter, Subfamily B; Cucurbitacins; Doxorubicin; Methanol; Plant Extracts; Rhodamines; Triterpenes; Verapamil Funding details: 022161 Funding details: Fundação para a Ciência e a Tecnologia, FCT, PTDC/MED-QUI/30591/2017 Funding details: European Regional Development Fund, ERDF Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, 2019/2020 Funding details: Programa Operacional Temático Factores de Competitividade, POFC, REDE/1501/REM/2005 Funding text 1: This study was supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal (PTDC/MED-QUI/30591/2017), Bilateral Portuguese-Hungarian Science & Technology Cooperation (FCT/NKFIH, 2019/2020), and Szeged Foundation for Cancer Research. The NMR spectrometer is part of the National NMR Network (PTNMR) and is partially supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). The authors also acknowledge Prof. Cordeiro, University of Lisbon, for high resolution mass data (FCT, REDE/1501/REM/2005). Funding text 2: This study was supported by Fundação para a Ciência e a Tecnologia (FCT) , Portugal (PTDC/MED-QUI/30591/2017), Bilateral Portuguese-Hungarian Science & Technology Cooperation (FCT/NKFIH, 2019/2020), and Szeged Foundation for Cancer Research. The NMR spectrometer is part of the National NMR Network ( PTNMR ) and is partially supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). The authors also acknowledge Prof. Cordeiro, University of Lisbon , for high resolution mass data (FCT, REDE/1501/REM/2005). LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Gajdács, Márió AU - Donadu, Matthew Gavino AU - Usai, Marianna AU - Marchetti, Mauro AU - Ferrari, Marco AU - Mazzarello, Vittorio AU - Zanetti, Stefania AU - Nagy, Fruzsina AU - Kovács, Renátó TI - Evaluation of the Antimicrobial and Antivirulent Potential of Essential Oils Isolated from Juniperus oxycedrus L. ssp. macrocarpa Aerial Parts JF - MICROORGANISMS J2 - MICROORGANISMS VL - 10 PY - 2022 IS - 4 PG - 19 SN - 2076-2607 DO - 10.3390/microorganisms10040758 UR - https://m2.mtmt.hu/api/publication/32768189 ID - 32768189 N1 - Funding Agency and Grant Number: Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00127/21/8, BO/00144/20/5]; National Research, Development, and Innovation Office [FK 138462]; New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research Development and Innovation Fund [uNKP-21-5-DE-473, uNKP-21-5-SZTE-540]; Pedagogy Research Program of the Hungarian Academy of Sciences; ESCMID's "30 under 30" Award; Foundation of Sardinia [2022.0443]; University of Sassari from the University Fund of Research Funding text: R.K. was supported by the Janos Bolyai Research Scholarship (BO/00127/21/8) of the Hungarian Academy of Sciences and was supported by the National Research, Development, and Innovation Office (FK 138462). M.G. was supported by the Janos Bolyai Research Scholarship (BO/00144/20/5) of the Hungarian Academy of Sciences. The research was supported by the uNKP-21-5-DE-473 (R.K.) and uNKP-21-5-SZTE-540 (M.G.) New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research Development and Innovation Fund. The study was supported by the Pedagogy Research Program of the Hungarian Academy of Sciences (2016-2020). M.G. would also like to acknowledge the support of ESCMID's "30 under 30" Award. M.G.D. was supported by from the Foundation of Sardinia, funding number 2022.0443. V.M. was supported by the University of Sassari from the University Fund of Research 2019-2020. AB - As a consequence of the worsening situation with multidrug-resistant (MDR) pathogens and a disparity in the commercialization of novel antimicrobial agents, scientists have been prompted to seek out new compounds with antimicrobial activity from a wide range of sources, including medicinal plants. In the present study, the antibacterial, antifungal, anti-virulence, and resistance-modulating properties of the essential oil from the Sardinian endemic Juniperus oxycedrus L. ssp. macrocarpa aerial parts were evaluated. The GC/MS analysis showed that the main compounds in the oil were alpha-pinene (56.63 +/- 0.24%), limonene (14.66 +/- 0.11%), and beta-pinene (13.42 +/- 0.09%). The essential oil showed potent antibacterial activity against Gram-positive bacteria (0.25-2 v/v%) and Salmonella spp. (4 v/v%). The strongest fungicidal activity was recorded against Candida auris sessile cells (median FICI was 0.088) but not against C. albicans biofilms (median FICI was 1). The oil showed potent efflux pump inhibitory properties in the case of Staphylococcus aureus and Escherichia coli. The therapeutic potential of Juniperus may be promising for future more extensive research and in vivo tests to develop new drugs against antibiotic and antifungal resistance. LA - English DB - MTMT ER - TY - JOUR AU - Stefkó, Dóra AU - Kúsz, Norbert AU - Szemerédi, Nikoletta AU - Barta, Anita AU - Spengler, Gabriella AU - Berkecz, Róbert AU - Hohmann, Judit AU - Vasas, Andrea TI - Unique Phenanthrenes from Juncus ensifolius and Their Antiproliferative and Synergistic Effects with the Conventional Anticancer Agent Doxorubicin against Human Cancer Cell Lines JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 3 PG - 17 SN - 1999-4923 DO - 10.3390/pharmaceutics14030608 UR - https://m2.mtmt.hu/api/publication/32793306 ID - 32793306 N1 - Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, 6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, 6725, Hungary Institute of Pharmaceutical Analysis, University of Szeged, Szeged, 6720, Hungary Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, 6720, Hungary Cited By :1 Export Date: 19 June 2023 Correspondence Address: Vasas, A.; Department of Pharmacognosy, Hungary; email: vasas.andrea@szte.hu Chemicals/CAS: 4 hydroxybenzaldehyde, 123-08-0; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; dimethyl sulfoxide, 67-68-5; doxorubicin, 23214-92-8, 25316-40-9; luteolin, 491-70-3; phenanthrene, 85-01-8 Tradenames: Avance DRX 500, Bruker; Multiscan EX, Thermo Labsystems, United States; Q Exactive, Thermo Manufacturers: Bruker; Jasco, Japan; Thermo; Thermo Labsystems, United States Funding details: GINOP-2.3.2-15-2016-00012 Funding details: Emberi Eroforrások Minisztériuma, EMMI, EFOP-3.6.3-VEKOP-16-2017-00009 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K128963 Funding details: National Research, Development and Innovation Office Funding text 1: Funding: This research was funded by the Economic Development and Innovation Operative Program GINOP-2.3.2-15-2016-00012, the UNKP-20-3-II New National Excellence Program of the Ministry of Human Capacities, EFOP-3.6.3-VEKOP-16-2017-00009, and the National Research, Development and Innovation Office, Hungary (NKFIH; K128963). LA - English DB - MTMT ER - TY - JOUR AU - Vágvölgyi, Máté AU - Kocsis, Endre AU - Nové, Márta AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Kele, Zoltán AU - Berkecz, Róbert AU - Gáti, Tamás AU - Tóth, Gábor AU - Hunyadi, Attila TI - Diversity-Oriented Synthesis Catalyzed by Diethylaminosulfur-Trifluoride—Preparation of New Antitumor Ecdysteroid Derivatives JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 7 PG - 18 SN - 1661-6596 DO - 10.3390/ijms23073447 UR - https://m2.mtmt.hu/api/publication/32770194 ID - 32770194 N1 - Institute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, H-6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged, H-6725, Hungary Department of Medical Chemistry, University of Szeged, Szeged, H-6720, Hungary Institute of Pharmaceutical Analysis, University of Szeged, Szeged, H-6720, Hungary Servier Research Institute of Medicinal Chemistry (SRIMC), Budapest, H-1031, Hungary NMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, H-1111, Hungary Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, H-6720, Hungary Export Date: 9 June 2023 Correspondence Address: Tóth, G.; NMR Group, Hungary; email: drtothgabor@t-online.hu Correspondence Address: Hunyadi, A.; Institute of Pharmacognosy, Hungary; email: hunyadi.a@pharmacognosy.hu Chemicals/CAS: cyclopropane, 75-19-4; doxorubicin, 23214-92-8, 25316-40-9; ecdysterone, 5289-74-7; diethylamine, 109-89-7, 660-68-4; fluorine, 7782-41-4; Diethylamines; diethylaminosulfur trifluoride; Ecdysteroids; Fluorine Manufacturers: Teva, Hungary Funding details: GINOP-2.3.2-15-2016-00012 Funding details: FEIF/646-4/2021-ITM_SZERZ Funding details: UNKP-21-4-SZTE-281 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K-134704, TKP2021-EGA-32 Funding details: National Research, Development and Innovation Office Funding text 1: Funding: This research was funded by the National Research, Development and Innovation Office, Hungary (NKFIH; K-134704 and TKP2021-EGA-32 by the Ministry of Innovation and Technology of Hungary), and the Economic Development and Innovation Operative Program GINOP-2.3.2-15-2016-00012, with the support of the Szeged Scientists Academy under the sponsorship of the Hungarian Ministry of Innovation and Technology (FEIF/646-4/2021-ITM_SZERZ). M.V. was supported by the New National Excellence Program of the Ministry of Human Capacities, Hungary (UNKP-21-4-SZTE-281). AB - Fluorine represents a privileged building block in pharmaceutical chemistry. Diethylaminosulfur-trifluoride (DAST) is a reagent commonly used for replacement of alcoholic hydroxyl groups with fluorine and is also known to catalyze water elimination and cyclic Beckmann-rearrangement type reactions. In this work we aimed to use DAST for diversity-oriented semisynthetic transformation of natural products bearing multiple hydroxyl groups to prepare new bioactive compounds. Four ecdysteroids, including a new constituent of Cyanotis arachnoidea, were selected as starting materials for DAST-catalyzed transformations. The newly prepared compounds represented combinations of various structural changes DAST was known to catalyze, and a unique cyclopropane ring closure that was found for the first time. Several compounds demonstrated in vitro antitumor properties. A new 17-N-acetylecdysteroid (13) exerted potent antiproliferative activity and no cytotoxicity on drug susceptible and multi-drug resistant mouse T-cell lymphoma cells. Further, compound 13 acted in significant synergism with doxorubicin without detectable direct ABCB1 inhibition. Our results demonstrate that DAST is a versatile tool for diversity-oriented synthesis to expand chemical space towards new bioactive compounds. LA - English DB - MTMT ER - TY - JOUR AU - Vesković, Ana AU - Nakarada, Đura AU - Vasiljević, Olga AU - Dobrov, Anatolie AU - Spengler, Gabriella AU - Enyedy, Éva Anna AU - Arion, Vladimir B. AU - Popović Bijelić, Ana TI - The Release of a Highly Cytotoxic Paullone Bearing a TEMPO Free Radical from the HSA Hydrogel: An EPR Spectroscopic Characterization JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 6 SP - 1174 PG - 19 SN - 1999-4923 DO - 10.3390/pharmaceutics14061174 UR - https://m2.mtmt.hu/api/publication/32851553 ID - 32851553 N1 - Faculty of Physical Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, 11158, Serbia Institute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, Vienna, A-1090, Austria MTA-SZTE Lendület Functional Metal Complexes Research Group, Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Cited By :2 Export Date: 7 June 2023 Correspondence Address: Bijelić, A.P.; Faculty of Physical Chemistry, Studentski trg 12-16, Serbia; email: ana@ffh.bg.ac.rs Chemicals/CAS: 5 doxylstearic acid, 29545-48-0; doxorubicin, 23214-92-8, 25316-40-9; etoposide, 33419-42-0, 433304-61-1; hydroxyl radical, 3352-57-6; oxaliplatin, 61825-94-3; regorafenib, 755037-03-7, 1019206-88-2; serum albumin, 9048-46-8; sodium chloride, 7647-14-5, 23724-87-0, 49658-21-1 Manufacturers: Sigma Aldrich, United StatesThermo, United States Funding details: 6062285 Funding details: Science Fund of the Republic of Serbia Funding text 1: Funding: This research and the APC were funded by the Science Fund of the Republic of Serbia, PROMIS, #6062285, PHYCAT. LA - English DB - MTMT ER - TY - JOUR AU - Wittmann, Christopher AU - Bacher, Felix AU - Enyedy, Éva Anna AU - Dömötör, Orsolya AU - Spengler, Gabriella AU - Madejski, Christian AU - Reynisson, Jóhannes AU - Arion, Vladimir B. TI - Highly Antiproliferative Latonduine and Indolo[2,3- c ]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile JF - JOURNAL OF MEDICINAL CHEMISTRY J2 - J MED CHEM VL - 65 PY - 2022 IS - 3 SP - 2238 EP - 2261 PG - 24 SN - 0022-2623 DO - 10.1021/acs.jmedchem.1c01740 UR - https://m2.mtmt.hu/api/publication/32639268 ID - 32639268 N1 - Institute of Inorganic Chemistry, The University of Vienna, Währinger Strasse, 42, Vienna, A1090, Austria Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary School of Pharmacy and Bioengineering, Keele University, Hornbeam Building, Staffordshire, ST5 5BG, United Kingdom Cited By :8 Export Date: 19 June 2023 CODEN: JMCMA Correspondence Address: Arion, V.B.; Institute of Inorganic Chemistry, Währinger Strasse, 42, Austria; email: vladimir.arion@univie.ac.at Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; cyclic AMP dependent protein kinase; DNA, 9007-49-2; doxorubicin, 23214-92-8, 25316-40-9; glycogen synthase kinase 3alpha; glycogen synthase kinase 3beta; protein serine threonine kinase; copper, 15158-11-9, 7440-50-8; protein kinase, 9026-43-1; Antineoplastic Agents; calf thymus DNA; Coordination Complexes; Copper; DNA; Heterocyclic Compounds, 3-Ring; Indoles; latonduine A; Protein Kinase Inhibitors; Protein Kinases; Quinolines Funding details: Austrian Science Fund, FWF, P31293-N37 Funding details: Hungarian Scientific Research Fund, OTKA, FK 124240, LP2019-6/2019 Funding text 1: Austrian Science Fund (FWF) is acknowledged for the grant no. P31293-N37. This research was also supported by the Hungarian Scientific Research Fund (OTKA FK 124240) and by the Eötvös Lóránd Research Network (LP2019-6/2019). LA - English DB - MTMT ER - TY - JOUR AU - Yazdani, Morteza AU - Béni, Zoltán AU - Dékány, Miklós AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Hohmann, Judit AU - Ványolós, Attila TI - Triterpenes from Pholiota populnea as Cytotoxic Agents and Chemosensitizers to Overcome Multidrug Resistance of Cancer Cells JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 85 PY - 2022 IS - 4 SP - 910 EP - 916 PG - 7 SN - 0163-3864 DO - 10.1021/acs.jnatprod.1c01024 UR - https://m2.mtmt.hu/api/publication/32746758 ID - 32746758 N1 - Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, 6720, Hungary Spectroscopic Research Department, Gedeon Richter Plc., Gyömroï út 19-21, Budapest, H-1103, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Faculty of Medicine, University of Szeged, Semmelweis utca 6, Szeged, H-6725, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Department of Pharmacognosy, Semmelweis University, Ülloï u. 26, Budapest, H-1085, Hungary Export Date: 1 June 2022 CODEN: JNPRD Correspondence Address: Hohmann, J.; Department of Pharmacognosy, Hungary; email: hohmann.judit@szte.hu Correspondence Address: Ványolós, A.; Department of Pharmacognosy, Ülloï u. 26, Hungary; email: vanyolos@pharmacognosy.hu LA - English DB - MTMT ER - TY - JOUR AU - Zeslawska, Ewa AU - Tejchman, Waldemar AU - Kincses, Annamária AU - Spengler, Gabriella AU - Nitek, Wojciech AU - Zuchowski, Grzegorz AU - Szymanska, Ewa TI - 5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 23 PY - 2022 IS - 18 PG - 16 SN - 1661-6596 DO - 10.3390/ijms231810812 UR - https://m2.mtmt.hu/api/publication/33179818 ID - 33179818 N1 - Institute of Biology, Pedagogical University of Krakow, Podchorążych 2, Kraków, 30-084, Poland Department of Medical Microbiology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, H-6720, Hungary Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków, 30-387, Poland Chair of Organic Chemistry, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Cited By :1 Export Date: 15 February 2023 Correspondence Address: Żesławska, E.; Institute of Biology, Podchorążych 2, Poland Correspondence Address: Szymańska, E.; Department of Technology and Biotechnology of Drugs, Medyczna 9, Poland; email: ewa.szymanska@uj.edu.pl Chemicals/CAS: verapamil, 152-11-4, 52-53-9; Antineoplastic Agents; Antiviral Agents; Verapamil Funding details: Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie, UP, BN.610-147/PBU/2020, BN.711-56/PBU/2021 Funding text 1: This research was funded by the Pedagogical University of Krakow, projects numbers BN.610-147/PBU/2020 and BN.711-56/PBU/2021. The APC was funded by the Pedagogical University of Krakow. AB - Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractive research directions is focused on the inhibition of MDR transporters, membrane proteins that extrude cytotoxic drugs from living cells. Here, we report the results of our studies on a series newly synthesized of 5-arylidenerhodanines and their ability to inhibit the ABCB1 efflux pump in mouse T-lymphoma cancer cells. In the series, compounds possessing a triphenylamine moiety and the carboxyl group in their structure were of particular interest. These amphiphilic compounds showed over 17-fold stronger efflux pump inhibitory effects than verapamil. The cytotoxic and antiproliferative effects of target rhodanines on T-lymphoma cells were also investigated. A putative binding mode for 11, one of the most potent P-gp inhibitors tested here, was predicted by molecular docking studies and discussed with regard to the binding mode of verapamil. LA - English DB - MTMT ER - TY - JOUR AU - Rácz, Bálint AU - Kincses, Annamária AU - Miguel, Benito-Lama AU - Ana, Gonzalez-Prádena AU - Enrique, Dominguez-Álvarez AU - Spengler, Gabriella TI - Symmetric Selenoesters as Potent Efflux Pump Inhibitors in Colon Adenocarcinoma Cells JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 68 PY - 2021 IS - Supplement 1 SP - 34 EP - 34 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/32471515 ID - 32471515 LA - English DB - MTMT ER - TY - JOUR AU - Béni, Zoltán AU - Dékány, Miklós AU - Sárközy, András AU - Kincses, Annamária AU - Spengler, Gabriella AU - Papp, Viktor AU - Hohmann, Judit AU - Ványolós, Attila TI - Triterpenes and Phenolic Compounds from the Fungus Fuscoporia torulosa: Isolation, Structure Determination and Biological Activity JF - MOLECULES J2 - MOLECULES VL - 26 PY - 2021 IS - 6 PG - 13 SN - 1420-3049 DO - 10.3390/molecules26061657 UR - https://m2.mtmt.hu/api/publication/31930155 ID - 31930155 N1 - Spectroscopic Research, Gedeon Richter Plc, Gyömrői út 19-21, Budapest, H-1103, Hungary Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm Square 10, Szeged, H-6720, Hungary Department of Botany, Hungarian University of Agriculture and Life Sciences, Villányi út 29-43, Budapest, H-1118, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Department of Pharmacognosy, Semmelweis University, Üllői u. 26, Budapest, H-1085, Hungary Cited By :4 Export Date: 8 February 2023 CODEN: MOLEF Correspondence Address: Hohmann, J.; Department of Pharmacognosy, Eötvös u. 6, Hungary; email: hohmann.judit@szte.hu Correspondence Address: Ványolós, A.; Department of Pharmacognosy, Eötvös u. 6, Hungary; email: vanyolosa@pharmacognosy.hu Chemicals/CAS: methanol, 67-56-1; Anti-Bacterial Agents; Antioxidants; Methanol; Phenols; Triterpenes Funding details: GINOP-2.3.2-15-2016-00012 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K135845 Funding details: National Research, Development and Innovation Office Funding text 1: Funding: Financial support for this research were provided by the Economic Development and Innovation Operative Program GINOP-2.3.2-15-2016-00012, and the National Research, Development and Innovation Office, Hungary (NKFIH; K135845). LA - English DB - MTMT ER - TY - JOUR AU - Besleaga, Iuliana AU - Stepanenko, Iryna AU - Petrasheuskaya, Tatsiana AU - Darvasiova, Denisa AU - Breza, Martin AU - Hammerstad, Marta AU - Marć, Małgorzata A. AU - Prado-Roller, Alexander AU - Spengler, Gabriella AU - Popović-Bijelić, Ana AU - Enyedy, Éva Anna AU - Rapta, Peter AU - Shutalev, Anatoly D. AU - Arion, Vladimir B. TI - Triapine Analogues and Their Copper(II) Complexes: Synthesis, Characterization, Solution Speciation, Redox Activity, Cytotoxicity, and mR2 RNR Inhibition JF - INORGANIC CHEMISTRY J2 - INORG CHEM VL - 60 PY - 2021 IS - 15 SP - 11297 EP - 11319 PG - 23 SN - 0020-1669 DO - 10.1021/acs.inorgchem.1c01275 UR - https://m2.mtmt.hu/api/publication/32112075 ID - 32112075 N1 - Funding Agency and Grant Number: Austrian Science FundAustrian Science Fund (FWF) [I4729]; Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [20-53-14002]; Lendulet program of the Hungarian Academy of Sciences [LP2019-6/2019]; National Research, Development and Innovation Office-NKFIA [FK 124240, GINOP-2.3.2-15-2016-00038]; Ministry of Human Capacities, Hungary [TKP-2020]; Scholarship Foundation of the Republic of Austria [ICM-2019-14969]; Slovak Research and Development AgencySlovak Research and Development Agency [APVV-15-0053, APVV-19-0024, DS-FR-19-0035]; Slovak Scientific Grant Agency VEGAVedecka grantova agentura MSVVaS SR a SAV (VEGA) [1/0504/20]; COST ActionEuropean Cooperation in Science and Technology (COST) [CA18202]; NECTAR-Network for Equilibria and Chemical Thermodynamics Advanced Research Funding text: The financial support of the Austrian Science Fund (Grant No. I4729) and of the Russian Foundation for Basic Research (Grant No. 20-53-14002) is gratefully acknowledged. This work was also supported by the Lendulet program of the Hungarian Academy of Sciences (LP2019-6/2019), the National Research, Development and Innovation Office-NKFIA through Project Nos. GINOP-2.3.2-15-2016-00038 and FK 124240 and the Ministry of Human Capacities, Hungary, Grant No. TKP-2020. T.V.P. is thankful for the support of Scholarship Foundation of the Republic of Austria (ICM-2019-14969). We are thankful to Dr. D. Dumitrescu for the collection of X-ray diffraction data for complex 2' at the XRD2 structural biology beamline, Elettra synchrotron. P.R. and D.D. acknowledge the support of Slovak Research and Development Agency (contract Nos. APVV-15-0053, APVV-19-0024 and DS-FR-19-0035) and Slovak Scientific Grant Agency VEGA (1/0504/20). This work was also supported by COST Action CA18202, NECTAR-Network for Equilibria and Chemical Thermodynamics Advanced Research. LA - English DB - MTMT ER - TY - JOUR AU - Cardoso, David AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Mulhovo, Silva AU - dos Santos, Daniel AU - Ferreira, Maria-José TI - Exploring the Monoterpene Indole Alkaloid Scaffold for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Cancer JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 14 PY - 2021 IS - 9 PG - 31 SN - 1424-8247 DO - 10.3390/ph14090862 UR - https://m2.mtmt.hu/api/publication/32287706 ID - 32287706 N1 - Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon, 1649-003, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Faculty of Medicine, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Centro de Estudos Moçambicanos e de Etnociências (CEMEC), Faculdade de Ciências Naturais e Matemática, Universidade Pedagógica Campus de Lhanguene, Av. De Moçambique, Maputo, 21402161, Mozambique LAQV@REQUIMTE/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto, 4169-007, Portugal Cited By :7 Export Date: 9 June 2023 Correspondence Address: Ferreira, M.-J.U.; Research Institute for Medicines (iMed.ULisboa), Av. Prof. Gama Pinto, Portugal; email: mjuferreira@ff.ulisboa.pt Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; doxorubicin, 23214-92-8, 25316-40-9; verapamil, 152-11-4, 52-53-9 Funding details: Fundação para a Ciência e a Tecnologia, FCT, GINOP-2.3.2-15-2016-00012, PD/BD/135291/2017, PTDC/MED-QUI/30591/2017 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, 2019/2020 Funding text 1: Funding: This study was supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal (projects: PTDC/MED-QUI/30591/2017, and SAICT-PAC/0019/2015;PhD grant PD/BD/135291/2017). The study was also supported by the GINOP-2.3.2-15-2016-00012 project (University of Szeged, Hungary) and the Bilateral Portuguese–Hungarian Science & Technology Cooperation (FCT/NKFIH, 2019/2020). Funding text 2: This study was supported by Funda??o para a Ci?ncia e a Tecnologia (FCT), Portugal (projects: PTDC/MED-QUI/30591/2017, and SAICT-PAC/0019/2015; PhD grant PD/BD/135291/2017). The study was also supported by the GINOP-2.3.2-15-2016-00012 project (University of Szeged, Hungary) and the Bilateral Portuguese?Hungarian Science & Technology Cooperation (FCT/NKFIH, 2019/2020). AB - Dregamine (1), a major monoterpene indole alkaloid isolated from Tabernaemontana elegans, was submitted to chemical transformation of the ketone function, yielding 19 azines (3-21) and 11 semicarbazones (22-32) bearing aliphatic or aromatic substituents. Their structures were assigned mainly by 1D and 2D NMR (COSY, HMQC, and HMBC) experiments. Compounds 3-32 were evaluated as multidrug resistance (MDR) reversers through functional and chemosensitivity assays in a human ABCB1-transfected mouse T-lymphoma cell model, overexpressing P-glycoprotein. A significant increase of P-gp inhibitory activity was observed for most derivatives, mainly those containing azine moieties with aromatic substituents. Compounds with trimethoxyphenyl (17) or naphthyl motifs (18, 19) were among the most active, exhibiting strong inhibition at 0.2 mu M. Moreover, most of the derivatives showed selective antiproliferative effects toward resistant cells, having a collateral sensitivity effect. In drug combination assays, all compounds showed to interact synergistically with doxorubicin. Selected compounds (12, 17, 18, 20, and 29) were evaluated in the ATPase activity assay, in which all compounds but 12 behaved as inhibitors. To gather further insights on drug-receptor interactions, in silico studies were also addressed. A QSAR model allowed us to deduce that compounds bearing bulky and lipophilic substituents were stronger P-gp inhibitors. LA - English DB - MTMT ER - TY - JOUR AU - Cardoso, David S.P. AU - Kincses, Annamária AU - Nové, Márta AU - Spengler, Gabriella AU - Mulhovo, Silva AU - Aires-de-Sousa, João AU - dos Santos, Daniel J.V. A. AU - Ferreira, Maria-José U. TI - Alkylated monoterpene indole alkaloid derivatives as potent P-glycoprotein inhibitors in resistant cancer cells JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 210 PY - 2021 PG - 14 SN - 0223-5234 DO - 10.1016/j.ejmech.2020.112985 UR - https://m2.mtmt.hu/api/publication/31656647 ID - 31656647 N1 - Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon, 1649-003, Portugal Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Centro de Estudos Moçambicanos e de Etnociências (CEMEC), Faculdade de Ciências Naturais e Matemática, Universidade Pedagógica Campus de Lhanguene, Av. de Moçambique, Maputo, 21402161, Mozambique LAQV and REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, 2829-516, Portugal LAQV@REQUIMTE/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto, 4169-007, Portugal Cited By :5 Export Date: 9 February 2023 CODEN: EJMCA Correspondence Address: Ferreira, M.-J.U.; Research Institute for Medicines (iMed.ULisboa), Av. Prof. Gama Pinto, Portugal; email: mjuferreira@ff.ulisboa.pt Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; doxorubicin, 23214-92-8, 25316-40-9; verapamil, 152-11-4, 52-53-9; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Indole Alkaloids Manufacturers: Egis, Hungary; Teva, Hungary; Teva, Israel Funding details: Fundação para a Ciência e a Tecnologia, FCT, PD/BD/135291/2017, PTDC/MED-QUI/30591/2017 Funding details: Ministério da Ciência, Tecnologia e Ensino Superior, MCTES, GINOP-2.3.2-15-2016-00012, UID/QUI/50006/2019 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, 2019/2020 Funding text 1: This study was financially supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal (projects: PTDC/MED-QUI/30591/2017 , and SAICT-PAC/0019/2015 ; PhD grant PD/BD/135291/2017 ). This work was also supported by the Associate Laboratory for Green Chemistry - LAQV which is financed by national funds from FCT/MCTES ( UID/QUI/50006/2019 ). David S. P. Cardoso thanks the MedChemTrain program that supported his PhD scholarship. The study was also supported by the GINOP-2.3.2-15-2016-00012 project ( University of Szeged, Hungary ) and by the Bilateral Portuguese-Hungarian Science & Technology Cooperation ( FCT / NKFIH , 2019/2020). The authors thank the Portuguese Embassy in Mozambique, as well as the Portuguese Office of International Affairs for plant transport. We also thank COST Action CA17104 STRATAGEM. LA - English DB - MTMT ER - TY - JOUR AU - Durães, Fernando AU - Cravo, Sara AU - Freitas-Silva, Joana AU - Szemerédi, Nikoletta AU - Martins-da-Costa, Paulo AU - Pinto, Eugénia AU - Tiritan, Maria Elizabeth AU - Spengler, Gabriella AU - Fernandes, Carla AU - Sousa, Emília AU - Pinto, Madalena TI - Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 14 PY - 2021 IS - 11 PG - 24 SN - 1424-8247 DO - 10.3390/ph14111141 UR - https://m2.mtmt.hu/api/publication/32491607 ID - 32491607 N1 - Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal CIIMAR—Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, Matosinhos, 4450-208, Portugal ICBAS—Institute of Biomedical Sciences Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Laboratory of Microbiology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal CESPU, Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Rua Central de Gandra 1317, Gandra, 4585-116, Portugal Cited By :1 Export Date: 7 February 2023 Correspondence Address: Fernandes, C.; Laboratory of Organic and Pharmaceutical Chemistry, Rua de Jorge Viterbo Ferreira 228, Portugal; email: cfernandes@ff.up.pt Correspondence Address: Sousa, E.; Laboratory of Organic and Pharmaceutical Chemistry, Rua de Jorge Viterbo Ferreira 228, Portugal; email: esousa@ff.up.pt Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; minocycline, 10118-90-8, 11006-27-2, 13614-98-7; reserpine, 50-55-5, 8001-95-4 Tradenames: d 13 9001; mbx 3132 Funding details: CHI-RALBIO ACTIVE-PI-3RL-IINFACTS-2019, CHIRALSINTESE-APSFCT-IINFACTS_2021 Funding details: European Commission, EC Funding details: Fundação para a Ciência e a Tecnologia, FCT, POCI-01–0145-FEDER-028736, PTDC/SAU-PUB/28736/2017, SFRH/BD/144681/2019, UIDP/04423/2020 Funding details: European Regional Development Fund, ERDF, NORTE-01-0145-FEDER-000040 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding text 1: Acknowledgments: The acrA gene inactivated mutant Salmonella enterica serovar Typhimurium SL1344 (SE03), was provided by Jessica Blair, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, UK. The methicillin and ofloxacin-resistant Staphylococcus aureus 272123 clinical isolate was provided by Leonard Amaral, Institute of Hygiene and Tropical Medicine, Lisbon, Portugal. The bacteria used for the QS assay were kindly provided by Ernő Szegedi, Institute of Viticulture and Enology, National ?gricultural Research Center, Ba-dacsonytomaj, Hungary. F.D. acknowledges FCT for his grant (SFRH/BD/144681/2019). The authors thank Gisela Adriano and Gábor Tóth for the technical support. Funding text 2: Funding: This research was supported by national funds through FCT (Foundation for Science and Technology) within the scope of UIDB/04423/2020, UIDP/04423/2020 (Group of Natural Products and Medicinal Chemistry—CIIMAR), and under the project PTDC/SAU-PUB/28736/2017 (reference POCI-01–0145-FEDER-028736), co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds and structured program of R&D&I ATLANTIDA (NORTE-01-0145-FEDER-000040), supported by NORTE2020, through ERDF; CHI-RALBIO ACTIVE-PI-3RL-IINFACTS-2019 and CHIRALSINTESE-APSFCT-IINFACTS_2021. LA - English DB - MTMT ER - TY - JOUR AU - Durães, Fernando AU - Szemerédi, Nikoletta AU - Kumla, Decha AU - Pinto, Madalena AU - Kijjoa, Anake AU - Spengler, Gabriella AU - Sousa, Emília TI - Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants JF - MARINE DRUGS J2 - MAR DRUGS VL - 19 PY - 2021 IS - 9 PG - 17 SN - 1660-3397 DO - 10.3390/md19090475 UR - https://m2.mtmt.hu/api/publication/32157094 ID - 32157094 N1 - Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal CIIMAR–Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, Matosinhos, 4450-208, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Faculty of Medicine, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary ICBAS–Institute of Biomedical Sciences Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Cited By :3 Export Date: 7 February 2023 CODEN: MDARE Correspondence Address: Spengler, G.; Department of Medical Microbiology, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Correspondence Address: Sousa, E.; Laboratory of Organic and Pharmaceutical Chemistry, Rua de Jorge Viterbo Ferreira, 228, Portugal; email: esousa@ff.up.pt Chemicals/CAS: 2 naphthylamine, 91-59-8; acetoacetic acid, 541-50-4, 623-58-5; carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; ciprofloxacin, 85721-33-1, 86393-32-0, 128074-72-6, 128074-76-0, 192934-52-4, 93107-08-5, 86483-48-9, 96186-80-0; doxorubicin, 23214-92-8, 25316-40-9; minocycline, 10118-90-8, 11006-27-2, 13614-98-7; ochratoxin, 303-47-9, 37203-43-3; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4 Tradenames: CLARIOstar Plus, BMG Labtech, Germany; Multiscan EX ELISA, Thermo Labsystems, United States Manufacturers: Sigma Aldrich, Germany; Teva, HungaryBMG Labtech, Germany; Greiner, Hungary; Thermo Labsystems, United States Funding details: CHIRALBIO ACTIVE-PI-3RL-IINFACTS-2019 Funding details: European Commission, EC Funding details: Fundação para a Ciência e a Tecnologia, FCT, POCI-01–0145-FEDER-028736, PTDC/SAU-PUB/28736/2017, SFRH/BD/144681/2019, UIDP/04423/2020 Funding details: European Regional Development Fund, ERDF, NORTE-01-0145-FEDER-000040 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding text 1: Funding: This research was supported by national funds through FCT (Foundation for Science and Technology) within the scope of UIDB/04423/2020, UIDP/04423/2020 (Group of Natural Products and Medicinal Chemistry—CIIMAR), and under the project PTDC/SAU-PUB/28736/2017 (reference POCI-01–0145-FEDER-028736), co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds and structured program of R&D&I ATLANTIDA (NORTE-01-0145-FEDER-000040), supported by NORTE2020, through ERDF, and CHIRALBIO ACTIVE-PI-3RL-IINFACTS-2019. Funding text 2: Acknowledgments: The acrA gene inactivated mutant Salmonella enterica serovar Typhimurium SL1344 (SE03), was provided by Jessica Blair, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, UK. The methicillin and ofloxacin-resistant Staphylococcus aureus 272123 clinical isolate was provided by Leonard Amaral, Institute of Hygiene and Tropical Medicine, Lisbon, Portugal. The bacteria used for the QS assay were kindly provided by Erno˝ Szegedi, Institute of Viticulture and Enology, National Agricultural Research Center, Badacsony-tomaj, Hungary. F.D. acknowledges FCT for his PhD grant (SFRH/BD/144681/2019). The authors thank Gábor Tóth for the technical support. LA - English DB - MTMT ER - TY - JOUR AU - Durães, Fernando AU - Resende, Diana I. S. P. AU - Palmeira, Andreia AU - Szemerédi, Nikoletta AU - Pinto, Madalena M. M. AU - Spengler, Gabriella AU - Sousa, Emília TI - Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 10 PY - 2021 IS - 5 PG - 17 SN - 2079-6382 DO - 10.3390/antibiotics10050600 UR - https://m2.mtmt.hu/api/publication/32025517 ID - 32025517 N1 - Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, Matosinhos, 4450-208, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Cited By :14 Export Date: 7 February 2023 Correspondence Address: Spengler, G.; Department of Medical Microbiology, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Correspondence Address: Sousa, E.; Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Rua de Jorge Viterbo Ferreira, 228, Portugal; email: esousa@ff.up.pt Chemicals/CAS: carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; crystal violet, 467-63-0, 548-62-9; dimethyl sulfoxide, 67-68-5; doxorubicin, 23214-92-8, 25316-40-9; minocycline, 10118-90-8, 11006-27-2, 13614-98-7; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4 Tradenames: Multiscan EX, Thermo Labsystems, United States Manufacturers: Sigma Aldrich, GermanyThermo Labsystems, United States Funding details: CHIRALBIO ACTIVE-PI-3RL-IINFACTS-2019 Funding details: European Commission, EC Funding details: Fundação para a Ciência e a Tecnologia, FCT, POCI-01–0145-FEDER-028736, PTDC/SAU-PUB/28736/2017, SFRH/BD/114681/2019, UIDP/04423/2020 Funding details: European Regional Development Fund, ERDF, NORTE-01-0145-FEDER-000040 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding text 1: Acknowledgments: The acrA gene-inactivated mutant Salmonella enterica serovar Typhimurium SL1344 (SE03), was provided by Jessica Blair, Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, UK. The methicillin and ofloxacin-resistant Staphylococcus aureus 272123 clinical isolate was provided by Leonard Amaral, Institute of Hygiene and Tropical Medicine, Lisbon, Portugal. The bacteria used for the QS assay were kindly provided by Erno˝ Szegedi, Institute of Viticulture and Enology, National Agricultural Research Center, Badacsony-tomaj, Hungary. F.D. acknowledges FCT for his PhD grant (SFRH/BD/114681/2019). The authors acknowledge Gábor Tóth for technical support. Funding text 2: Funding: This research was supported by national funds through FCT (Foundation for Science and Technology) within the scope of UIDB/04423/2020, UIDP/04423/2020 (Group of Natural Products and Medicinal Chemistry—CIIMAR), and under the project PTDC/SAU-PUB/28736/2017 (reference POCI-01–0145-FEDER-028736), co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds, as well as structured program of R&D&I ATLANTIDA (NORTE-01-0145-FEDER-000040), supported by NORTE2020, through ERDF, and CHIRALBIO ACTIVE-PI-3RL-IINFACTS-2019. LA - English DB - MTMT ER - TY - JOUR AU - Enyedy, Éva Anna AU - Petrasheuskaya, Tatsiana AU - Kiss, Márton Attila AU - Wernitznig, Debora AU - Wenisch, Dominik AU - Keppler, Bernhard K. AU - Spengler, Gabriella AU - May, Nóra Veronika AU - Nagyné Frank, Éva AU - Dömötör, Orsolya TI - Complex formation of an estrone-salicylaldehyde semicarbazone hybrid with copper(II) and gallium(III): Solution equilibria and biological activity JF - JOURNAL OF INORGANIC BIOCHEMISTRY J2 - J INORG BIOCHEM VL - 220 PY - 2021 PG - 12 SN - 0162-0134 DO - 10.1016/j.jinorgbio.2021.111468 UR - https://m2.mtmt.hu/api/publication/31989135 ID - 31989135 N1 - Received 16 March 2021, Revised 8 April 2021, Accepted 18 April 2021, Available online 24 April 2021. LA - English DB - MTMT ER - TY - JOUR AU - Fernando, Durães AU - Andreia, Palmeira AU - Bárbara, Cruz AU - Joana, Freitas-Silva AU - Szemerédi, Nikoletta AU - Luís, Gales AU - Paulo, Martins da Costa AU - Fernando, Remião AU - Renata, Silva AU - Madalena, Pinto AU - Spengler, Gabriella AU - Emília, Sousa TI - Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2021 IS - 6 PG - 30 SN - 1999-4923 DO - 10.3390/ph14060572 UR - https://m2.mtmt.hu/api/publication/32072454 ID - 32072454 N1 - Laboratory of Organic and Pharmaceutical Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, Porto, 4050-313, Portugal CIIMAR—Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, Matosinhos, 4450-208, Portugal UCIBIO-REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal ICBAS—Institute of Biomedical Sciences Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Faculty of Medicine, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Department of Molecular Biology, ICBAS—Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Rua de Jorge Viterbo Ferreira 228, Porto, 4050-313, Portugal Bioengineering & Synthetic Microbiology, I3S—Instituto de Investigação e Inovação em Saúde, University of Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal Cited By :5 Export Date: 7 February 2023 Correspondence Address: Spengler, G.; Department of Medical Microbiology, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Correspondence Address: Sousa, E.; Laboratory of Organic and Pharmaceutical Chemistry, Rua de Jorge Viterbo Ferreira, 228, Portugal; email: esousa@ff.up.pt Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; ethidium bromide, 1239-45-8; flupentixol, 2413-38-9, 2709-56-0; minocycline, 10118-90-8, 11006-27-2, 13614-98-7; reserpine, 50-55-5, 8001-95-4; verapamil, 152-11-4, 52-53-9 Tradenames: d 13 9001, Perkin Elmer; mbx 3132, Perkin Elmer Manufacturers: Perkin Elmer Funding details: CHIRALBIO ACTIVE-PI-3RL-IINFACTS-2019 Funding details: European Commission, EC Funding details: Fundação para a Ciência e a Tecnologia, FCT, POCI-01–0145-FEDER-028736, PTDC/SAU-PUB/28736/2017, UIDP/04423/2020 Funding details: European Regional Development Fund, ERDF, NORTE-01-0145-FEDER-000040 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding text 1: This research was supported by national funds through FCT (Foundation for Science and Technology) within the scope of UIDB/04423/2020, UIDP/04423/2020 (Group of Natural Products and Medicinal Chemistry-CIIMAR), and under the project PTDC/SAU-PUB/28736/2017 (reference POCI-01–0145-FEDER-028736), co-financed by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds and structured program of R&D&I ATLANTIDA (NORTE-01-0145-FEDER-000040), supported by NORTE2020, through ERDF, and CHIRALBIO ACTIVE-PI-3RL-IINFACTS-2019. LA - English DB - MTMT ER - TY - JOUR AU - Ferreira, Ricardo J. AU - Spengler, Gabriella AU - Orthaber, Andreas AU - dos Santos, Daniel J. V. A. AU - Ferreira, Maria-José U. TI - Pedrolane, a Polycyclic Diterpene Scaffold Containing a Bicyclo[2.2.1]heptane System, from Euphorbia pedroi JF - ORGANIC LETTERS J2 - ORG LETT VL - 23 PY - 2021 IS - 2 SP - 274 EP - 278 PG - 5 SN - 1523-7060 DO - 10.1021/acs.orglett.0c03647 UR - https://m2.mtmt.hu/api/publication/31790652 ID - 31790652 N1 - Research Institute for Medicines (IMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisbon, 1649-003, Portugal Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Department of Chemistry, Ångström Laboratory, Box 523, Uppsala University, Uppsala, 75120, Sweden LAQV@REQUIMTE/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto, 4169-007, Portugal Cited By :10 Export Date: 19 January 2023 CODEN: ORLEF Correspondence Address: Ferreira, M.-J.U.; Research Institute for Medicines (IMed.ULisboa), Av. Prof. Gama Pinto, Portugal; email: mjuferreira@ff.ulisboa.pt Chemicals/CAS: Diterpenes Funding details: GINOP-2.3.2-15-2016-00012, PTDC/MED-QUI/30591/2017, SAICTPAC/0019/2015 Funding details: Fundação para a Ciência e a Tecnologia, FCT Funding details: Vetenskapsrådet, VR, 2017-03727, SFRH/BD/84285/2012 Funding details: Programa Operacional Temático Factores de Competitividade, POFC Funding text 1: This project received funding from European Structural & Investment Funds through the COMPETE Programme and from National Funds through FCT, Portugal (Fundação para a Ciência e a Tecnologia), under the Program Grants SAICTPAC/0019/2015 and PTDC/MED-QUI/30591/2017. This study was also supported by the project GINOP-2.3.2-15-2016-00012 (Hungary) and from Swedish Research Council (Vetenskapsrådet 2017-03727). Ricardo J. Ferreira acknowledges FCT for the PhD grant SFRH/BD/84285/2012. We also acknowledge Dr. T. Vasconcelos, ISA, Universidade de Lisboa, for plant material identification. LA - English DB - MTMT ER - TY - JOUR AU - Kaczor, Aneta AU - Szemerédi, Nikoletta AU - Kucwaj-Brysz, Katarzyna AU - Dąbrowska, Monika AU - Starek, Małgorzata AU - Latacz, Gniewomir AU - Spengler, Gabriella AU - Handzlik, Jadwiga TI - Computer‐aided search for 5‐arylideneimidazolone anticancer agents able to overcome ABCB1‐based multidrug resistance JF - CHEMMEDCHEM J2 - CHEMMEDCHEM VL - 16 PY - 2021 IS - 15 SP - 2386 EP - 2401 PG - 16 SN - 1860-7179 DO - 10.1002/cmdc.202100252 UR - https://m2.mtmt.hu/api/publication/32021264 ID - 32021264 N1 - Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, Kraków, 30-688, Poland Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Department of Inorganic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, Kraków, 30-688, Poland Cited By :3 Export Date: 15 June 2023 CODEN: CHEMG Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, 9 Medyczna Street, Poland; email: j.handzlik@uj.edu.pl Chemicals/CAS: adenosine triphosphatase, 37289-25-1, 9000-83-3; doxorubicin, 23214-92-8, 25316-40-9; rhodamine 123, 62669-70-9; tariquidar, 206873-63-4; verapamil, 152-11-4, 52-53-9 Funding details: Uniwersytet Jagielloński Collegium Medicum, N42/DBS/000027, N42/DBS/000070 Funding details: Ministerstwo Edukacji i Nauki, MNiSW, 0169/DIA/2017/46 Funding text 1: This research was funded by the Ministry of Science and Higher Education budget funds for science in 2017–2020, as a research project within “Diamond Grant” no. 0169/DIA/2017/46 and Jagiellonian University Medical College grants, numbers N42/DBS/000070 and N42/DBS/000027. The authors thank Maria Kaleta and Piotr Mazur for their irreplaceable support in the synthetic work. The authors also thank Veronica Monasterio, who participated in synthesis during her Student Exchange Programme in 2019. LA - English DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Rácz, Bálint AU - Baaity, Zain AU - Vásárhelyi, Orsolya AU - Kristóf, Erzsébet AU - Somogyvári, Ferenc AU - Spengler, Gabriella TI - The Relationship between Antibiotic Susceptibility and pH in the Case of Uropathogenic Bacteria JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 10 PY - 2021 IS - 12 SP - 1431 PG - 10 SN - 2079-6382 DO - 10.3390/antibiotics10121431 UR - https://m2.mtmt.hu/api/publication/32507776 ID - 32507776 N1 - Export Date: 13 April 2023 Correspondence Address: Somogyvári, F.; Albert Szent-Györgyi Health Center, Semmelweis utca 6, Hungary; email: somogyvari.ferenc@med.u-szeged.hu Correspondence Address: Spengler, G.; Albert Szent-Györgyi Health Center, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Chemicals/CAS: ampicillin, 69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0; ciprofloxacin, 85721-33-1, 86393-32-0, 128074-72-6, 128074-76-0, 192934-52-4, 93107-08-5, 86483-48-9, 96186-80-0; erythromycin, 114-07-8, 70536-18-4; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0 Tradenames: CFX 96, Biorad, United States; ImageLab, Biorad, United States; NanoDrop, Thermo, United States; NucleoSpin, Biorad, United States; QIAamp, Qiagen, United States; SmartSpec, Biorad, United States Manufacturers: Biorad, United States; Qiagen, United States; Thermo, United States Funding details: EFOP-3.6.3-VEKOP-16-2017-00009, GINOP-2.3.2-15-2016-00038 Funding text 1: This research was funded by the projects SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine and GINOP-2.3.2-15-2016-00038 (Hungary). B.R. was supported by the project EFOP-3.6.3-VEKOP-16-2017-00009 (Hungary).The authors thank Edit Urbán for providing the clinical bacterial strains. LA - English DB - MTMT ER - TY - JOUR AU - Kúsz, Norbert AU - Stefkó, Dóra AU - Barta, Anita AU - Kincses, Annamária AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Hohmann, Judit AU - Vasas, Andrea TI - Juncaceae Species as Promising Sources of Phenanthrenes: Antiproliferative Compounds from Juncus maritimus Lam JF - MOLECULES J2 - MOLECULES VL - 26 PY - 2021 IS - 4 PG - 11 SN - 1420-3049 DO - 10.3390/molecules26040999 UR - https://m2.mtmt.hu/api/publication/31921807 ID - 31921807 N1 - Funding Agency and Grant Number: New National Excellence Program of the Ministry for Innovation and Technology from the National Research, Development and Innovation Funds [UNKP-20-4, UNKP-18-3-I, NTP-NFTO-19-B-0208, EFOP 3.6.3-VEKOP16-2017-00009]; Economic Development and Innovation Operative Programme of the Ministry of Human Capacities [GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00020, 20391-3/2018/FEKUSTRAT]; National Research, Development and Innovation Office, Hungary (NKFIH) [K128963] Funding text: This research was funded by the UNKP-20-4 (first author N.K.) and UNKP-18-3-I (first author D.S.)-New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Funds, grant NTP-NFTO-19-B-0208, EFOP 3.6.3-VEKOP16-2017-00009, Economic Development and Innovation Operative Programme GINOP-2.3.2-15-2016-00012, GINOP-2.3.2-15-2016-00020, and grant 20391-3/2018/FEKUSTRAT of the Ministry of Human Capacities, and the National Research, Development and Innovation Office, Hungary (NKFIH; K128963). AB - Juncaceae family represents an abundant source of phenanthrenes. In continuation of our work aiming at the isolation of biologically active compounds from Juncaceae species, Juncus maritimus Lam. was subjected to phytochemical and pharmacological investigations. The isolation process was carried out by using combined extraction and chromatographic methods. The structures of the obtained chemical compounds were elucidated by spectroscopic analysis, including HRESIMS, 1D (H-1, C-13-JMOD), and 2D (H-1-H-1-COSY, HSQC, HMBC, NOESY) NMR spectra. Four new [maritins A-D (1-4)] and seven known phenanthrenes (5-11) were isolated from the plant, of which two (4 and 11) are phenanthrene dimers composed of effusol monomers. Maritin C (3) has an unusual 4,5-ethanophenanthrene skeleton most likely produced by biosynthetic incorporation of a vinyl group into a cyclohexadiene ring. Compounds 1-11 were tested for their antiproliferative activity on seven human tumor cell lines (HeLa, HTM-26, T-47D, A2780, A2780cis, MCF-7, KCR) and one normal cell line (MRC-5) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The dimeric phenanthrenes showed strong antiproliferative activity against T-47D cells with IC50 values of 9.1 and 6.2 mu M, respectively. LA - English DB - MTMT ER - TY - JOUR AU - Szemerédi, Nikoletta AU - Kincses, Annamária AU - Gábor, Tóth AU - Enrique, Domingez-Alvarez AU - Spengler, Gabriella TI - Selenoesters as Efflux Pump Inhibitors in Bacteria and Cancer Cells JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 68 PY - 2021 IS - Supplement 1 SP - 116 EP - 116 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/32471631 ID - 32471631 LA - English DB - MTMT ER - TY - JOUR AU - Szemerédi, Nikoletta AU - Bo, Young Huh AU - Rácz, Bálint AU - Spengler, Gabriella AU - Kincses, Annamária TI - Inhibition of Quorum Sensing by Conventional Antibiotics and Resistance Modifiers JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 68 PY - 2021 IS - Supplement 1 SP - 115 EP - 115 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/32471622 ID - 32471622 LA - English DB - MTMT ER - TY - JOUR AU - Szemerédi, Nikoletta AU - Kincses, Annamária AU - Jitka, Viktorova AU - Enrique, Dominguez-Álvarez AU - Spengler, Gabriella TI - Selenoesters as Potential Quorum Sensing-Inhibiting and Anti-biofilm Compounds in Bacteria JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 68 PY - 2021 IS - Supplement 1 SP - 40 EP - 40 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/32471526 ID - 32471526 LA - English DB - MTMT ER - TY - JOUR AU - Pivarcsik, Tamás AU - Dömötör, Orsolya AU - Mészáros, János Péter AU - May, Nóra Veronika AU - Spengler, Gabriella AU - Csuvik, Oszkár AU - Szatmári, István AU - Enyedy, Éva Anna TI - 8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 20 PG - 29 SN - 1661-6596 DO - 10.3390/ijms222011281 UR - https://m2.mtmt.hu/api/publication/32463170 ID - 32463170 N1 - MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Centre for Structural Science, Research Centre for Natural Sciences, Magyar Tudósok Körútja 2, Budapest, H-1117, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Institute of Pharmaceutical Chemistry and Stereochemistry Research Group of Hungarian Academy of Sciences, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Cited By :7 Export Date: 9 June 2023 Correspondence Address: Enyedy, É.A.; MTA-SZTE Lendület Functional Metal Complexes Research Group, Dóm tér 7, Hungary; email: enyedy@chem.u-szeged.hu Chemicals/CAS: 8 quinolinol, 148-24-3; amino acid, 65072-01-7; rhodium, 7440-16-6; ruthenium, 7440-18-8; Amino Acids; Antineoplastic Agents; Coordination Complexes; Oxyquinoline; Rhodium; Ruthenium Funding details: National Research, Development and Innovation Office, FK124240, GINOP-2.3.2-15-2016-00038, K124544 Funding details: Emberi Eroforrások Minisztériuma, EMMI, TKP-2020 Funding text 1: Funding: This work was supported by National Research, Development and Innovation Office-NKFIA through projects FK124240, K124544, GINOP-2.3.2-15-2016-00038, and Ministry of Human Capacities through project Hungary grant TKP-2020. LA - English DB - MTMT ER - TY - JOUR AU - Pivarcsik, Tamás AU - Tóth, Gábor AU - Szemerédi, Nikoletta AU - Bogdanov, Anita AU - Spengler, Gabriella AU - Kljun, Jakob AU - Kladnik, Jerneja AU - Turel, Iztok AU - Enyedy, Éva Anna TI - Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected β-Diketone, 8-Hydroxyquinoline and Pyrithione Ligands JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 14 PY - 2021 IS - 6 PG - 24 SN - 1424-8247 DO - 10.3390/ph14060518 UR - https://m2.mtmt.hu/api/publication/32039543 ID - 32039543 N1 - MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm Tér 7, Szeged, H-6720, Hungary Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm Tér 7, Szeged, H-6720, Hungary Department of Medical Microbiology, Albert Szent-Györgyi Health Center, Faculty of Medicine, University of Szeged, Semmelweis u. 6, Szeged, H-6725, Hungary Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, 1000, Slovenia Export Date: 29 June 2021 Correspondence Address: Spengler, G.; MTA-SZTE Lendület Functional Metal Complexes Research Group, Dóm Tér 7, Hungary; email: spengler.gabriella@med.u-szeged.hu Correspondence Address: Turel, I.; Faculty of Chemistry and Chemical Technology, Slovenia; email: Iztok.Turel@fkkt.uni-lj.si Correspondence Address: Enyedy, É.A.; MTA-SZTE Lendület Functional Metal Complexes Research Group, Dóm Tér 7, Hungary; email: enyedy@chem.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Rimpilauinen, Tatu AU - Nunes, Alexandra AU - Calado, Rita AU - Fernandes, Ana S. AU - Andrade, Joana AU - Ntungwe, Epole AU - Spengler, Gabriella AU - Szemerédi, Nikoletta AU - Rodrigues, Joao AU - Gomes, Joao Paulo AU - Rijo, Patricia AU - Candeias, Nuno R. TI - Increased antibacterial properties of indoline-derived phenolic Mannich bases JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 220 PY - 2021 PG - 11 SN - 0223-5234 DO - 10.1016/j.ejmech.2021.113459 UR - https://m2.mtmt.hu/api/publication/31984388 ID - 31984388 N1 - Faculty of Engineering and Natural Sciences, Tampere University, Korkeakoulunkatu 8, Tampere, 33101, Finland Department of Infectious Diseases, National Institute of Health, Avenida Padre Cruz, Lisboa, 1649-016, Portugal Faculty of Veterinary Medicine, Lusófona University, Campo Grande 376, Lisboa, 1749-024, Portugal CBIOS-Universidade Lusófona Research Center for Biosciences & Health Technologies, Campo Grande 376, Lisboa, 1749-024, Portugal Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Instituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Av. Prof. Gama Pinto, Lisboa, 1649-003, Portugal LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, 3810-193, Portugal Cited By :3 Export Date: 10 February 2023 CODEN: EJMCA Correspondence Address: Candeias, N.R.; LAQV-REQUIMTE, Portugal; email: ncandeias@ua.pt Correspondence Address: Nunes, A.; Department of Infectious Diseases, Avenida Padre Cruz, Portugal; email: alexandra.nunes@insa.min-saude.pt Chemicals/CAS: picric acid, 14798-26-6, 88-89-1; 1,1-diphenyl-2-picrylhydrazyl; Anti-Bacterial Agents; Antioxidants; Biphenyl Compounds; Indoles; indoline; Mannich Bases; Phenols; Picrates Funding details: Fundação para a Ciência e a Tecnologia, FCT, CEE-CINST/2018, UIDB/50006/2020 Funding details: Academy of Finland, AKA, 326487 Funding text 1: Jane and Aatos Erkko Foundation, Academy of Finland (Decision 326487 ) and Fundação para a Ciência e Tecnologia ( UIDB/50006/2020 and CEE-CINST/2018 ) are acknowledged for financial support. We thank Lijo George (Faculty of Engineering and Natural Sciences, TAU) for HRMS measurements. LA - English DB - MTMT ER - TY - JOUR AU - Savchenko, Rimma G. AU - Nové, Márta AU - Spengler, Gabriella AU - Hunyadi, Attila AU - Parfenova, Lyudmila V. TI - In vitro adjuvant antitumor activity of various classes of semi-synthetic poststerone derivatives JF - BIOORGANIC CHEMISTRY J2 - BIOORG CHEM VL - 106 PY - 2021 SN - 0045-2068 DO - 10.1016/j.bioorg.2020.104485 UR - https://m2.mtmt.hu/api/publication/31696470 ID - 31696470 N1 - Institute of Petrochemistry and Catalysis of Russian Academy of Sciences, 141, Prospekt Oktyabrya, Ufa, 450075, Russian Federation Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm sq. 9, Szeged, 6720, Hungary Institute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Eötvös str. 6, Szeged, 6720, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös str. 6, Szeged, 6720, Hungary Cited By :6 Export Date: 20 June 2023 CODEN: BOCMB Correspondence Address: Hunyadi, A.; Institute of Pharmacognosy, Eötvös str. 6, Hungary; email: hunyadi.a@pharmacognosy.hu Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; tariquidar, 206873-63-4; ecdysterone, 5289-74-7; Antineoplastic Agents; Ecdysterone; poststerone Manufacturers: Teva, Hungary Funding details: 3.6.3-VEKOP-16-2017-00009 Funding details: Russian Foundation for Basic Research, РФФИ, 20-03-00649, AAAA-A19-119022290012-3 Funding details: Russian Academy of Sciences, РАН Funding details: Ministry of Education and Science of the Russian Federation, Minobrnauka, 2019-05-595-000-058 Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K119770 Funding details: National Research, Development and Innovation Office Funding text 1: The authors thank the Russian Foundation for Basic Research (Grant No. 20-03-00649) for financial support. A part of the studies was carried out in accordance with the Federal Program No. AAAA-A19-119022290012-3. The results were obtained with the financial support of the Russian Ministry of Education and Science (project no. 2019-05-595-000-058) on unique equipment at the 'Agidel' Collective Usage Center (Ufa Federal Research Center, Russian Academy of Sciences). Financial support from the National Research, Development and Innovation Office, Hungary (NKFIH; K119770), and from the Ministry of Human Capacities, Hungary (20391-3/2018/FEKUSTRAT) is acknowledged. M.N. was supported by EFOP 3.6.3-VEKOP-16-2017-00009. Funding text 2: The authors thank the Russian Foundation for Basic Research (Grant No. 20-03-00649) for financial support. A part of the studies was carried out in accordance with the Federal Program No. AAAA-A19-119022290012-3. The results were obtained with the financial support of the Russian Ministry of Education and Science (project no. 2019-05-595-000-058) on unique equipment at the 'Agidel' Collective Usage Center (Ufa Federal Research Center, Russian Academy of Sciences). Financial support from the National Research, Development and Innovation Office, Hungary (NKFIH; K119770), and from the Ministry of Human Capacities, Hungary (20391-3/2018/FEKUSTRAT) is acknowledged. M.N. was supported by EFOP 3.6.3-VEKOP-16-2017-00009. LA - English DB - MTMT ER - TY - JOUR AU - Stefkó, Dóra AU - Kúsz, Norbert AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Hohmann, Judit AU - Vasas, Andrea TI - Biologically active phenanthrenes from four Juncus species native to Hungary JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 87 PY - 2021 IS - 15 SP - 1251 EP - 1251 PG - 1 SN - 0032-0943 DO - 10.1055/s-0041-1736786 UR - https://m2.mtmt.hu/api/publication/33041581 ID - 33041581 LA - English DB - MTMT ER - TY - JOUR AU - Stepanenko, Iryna AU - Babak, Maria V. AU - Spengler, Gabriella AU - Hammerstad, Marta AU - Popovic-Bijelic, Ana AU - Shova, Sergiu AU - Buchel, Gabriel E. AU - Darvasiova, Denisa AU - Rapta, Peter AU - Arion, Vladimir B. TI - Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity JF - BIOMOLECULES J2 - BIOMOLECULES VL - 11 PY - 2021 IS - 6 PG - 24 SN - 2218-273X DO - 10.3390/biom11060862 UR - https://m2.mtmt.hu/api/publication/32096604 ID - 32096604 N1 - Funding Agency and Grant Number: Pro Festival Foundation, Vaduz, Liechtenstein; Slovak Grant Agencies APVVSlovak Research and Development Agency [APVV-15-0053, APVV-19-0024, DS-FR-190035]; VEGAVedecka grantova agentura MSVVaS SR a SAV (VEGA)European Commission [1/0504/20]; Austrian Science Fund (FWF)Austrian Science Fund (FWF) [P28223] Funding text: This work was generously supported by Pro Festival Foundation, Vaduz, Liechtenstein, by the Slovak Grant Agencies APVV (contract Nos. APVV-15-0053, APVV-19-0024 and DS-FR-190035) and VEGA (contracts No. 1/0504/20), as well as by Austrian Science Fund (FWF) via grant No P28223. AB - A series of thiosemicarbazone-coumarin hybrids (HL1-HL3 and H2L4) has been synthesised in 12 steps and used for the preparation of mono- and dinuclear copper(II) complexes, namely Cu(HL1)Cl-2 (1), Cu(HL2)Cl-2 (2), Cu(HL3)Cl-2 (3) and Cu-2(H2L4)Cl-4 (4), isolated in hydrated or solvated forms. Both the organic hybrids and their copper(II) and dicopper(II) complexes were comprehensively characterised by analytical and spectroscopic techniques, i.e., elemental analysis, ESI mass spectrometry, 1D and 2D NMR, IR and UV-vis spectroscopies, cyclic voltammetry (CV) and spectroelectrochemistry (SEC). Re-crystallisation of 1 from methanol afforded single crystals of copper(II) complex with monoanionic ligand Cu(L-1)Cl, which could be studied by single crystal X-ray diffraction (SC-XRD). The prepared copper(II) complexes and their metal-free ligands revealed antiproliferative activity against highly resistant cancer cell lines, including triple negative breast cancer cells MDA-MB-231, sensitive COLO-205 and multidrug resistant COLO-320 colorectal adenocarcinoma cell lines, as well as in healthy human lung fibroblasts MRC-5 and compared to those for triapine and doxorubicin. In addition, their ability to reduce the tyrosyl radical in mouse R2 protein of ribonucleotide reductase has been ascertained by EPR spectroscopy and the results were compared with those for triapine. LA - English DB - MTMT ER - TY - JOUR AU - Szemerédi, Nikoletta AU - Dobiasová, Simona AU - Salardón-Jiménez, Noemi AU - Kincses, Annamária AU - Nové, Márta AU - Habibullah, Giyaullah AU - Sevilla-Hernández, Clotilde AU - Benito-Lama, Miguel AU - Alonso-Martínez, Francisco-Javier AU - Viktorová, Jitka AU - Spengler, Gabriella AU - Domínguez-Álvarez, Enrique TI - Cyano- and Ketone-Containing Selenoesters as Multi-Target Compounds against Resistant Cancers JF - CANCERS J2 - CANCERS VL - 13 PY - 2021 IS - 18 PG - 26 SN - 2072-6694 DO - 10.3390/cancers13184563 UR - https://m2.mtmt.hu/api/publication/32201163 ID - 32201163 N1 - Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Faculty of Medicine, University of Szeged, Semmelweis utca 6, Szeged, 6725, Hungary Department of Biochemistry and Microbiology, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technická 3, Prague 6166 28, Czech Republic Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, Madrid, 28006, Spain Cited By :7 Export Date: 8 February 2023 Correspondence Address: Viktorová, J.; Department of Biochemistry and Microbiology, Technická 3, Prague 6, Czech Republic; email: prokesoj@vscht.cz Correspondence Address: Spengler, G.; Department of Medical Microbiology, Semmelweis utca 6, Hungary; email: spengler.gabriella@med.u-szeged.hu Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General (IQOG-CSIC), Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Chemicals/CAS: adenosine triphosphatase, 37289-25-1, 9000-83-3 Funding details: LTC19007 Funding details: GINOP-2.3.2-15-2016-00038 Funding details: European Cooperation in Science and Technology, COST Funding details: Consejo Superior de Investigaciones Científicas, CSIC, 22010090, LINKA20285 Funding text 1: Funding: The study was supported by the projects SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine and GINOP-2.3.2-15-2016-00038 (Hungary); and Consejo Superior de Investigaciones Científicas (CSIC, Spain, project LINKA20285). This research was funded by VISEGRAD FUND, grant number 22010090; and by the mobility project from the Czech Ministry of Education, Youth and Sports INTER-COST, grant number LTC19007. The study was supported by COST Action 17104 New Diagnostic and Therapeutic Tools Against Multidrug Resistant Tumours (STRATAGEM). The study was supported also by two cultural associations: “Trevinca” and “Iniciativas Ropelanas”. LA - English DB - MTMT ER - TY - JOUR AU - Yazdani, Morteza AU - Hohmann, Judit AU - Kincses, Annamária AU - Spengler, Gabriella AU - Béni, Zoltán AU - Dékány, Miklós AU - Ványolós, Attila TI - Pholiols A-D and other triterpenes from Pholiota populnea and their activity against colon carcinoma JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 87 PY - 2021 IS - 15 SP - 1302 EP - 1302 PG - 1 SN - 0032-0943 DO - 10.1055/s-0041-1736949 UR - https://m2.mtmt.hu/api/publication/33041580 ID - 33041580 LA - English DB - MTMT ER - TY - JOUR AU - Żesławska, Ewa AU - Kucwaj-Brysz, Katarzyna AU - Kincses, Annamária AU - Spengler, Gabriella AU - Szymańska, Ewa AU - Czopek, Anna AU - Marć, Małgorzata Anna AU - Kaczor, Aneta AU - Nitek, Wojciech AU - Domínguez-Álvarez, Enrique AU - Latacz, Gniewomir AU - Kieć-Kononowicz, Katarzyna AU - Handzlik, Jadwiga TI - An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells JF - BIOORGANIC CHEMISTRY J2 - BIOORG CHEM VL - 109 PY - 2021 PG - 18 SN - 0045-2068 DO - 10.1016/j.bioorg.2021.104735 UR - https://m2.mtmt.hu/api/publication/31933965 ID - 31933965 N1 - Institute of Biology, Pedagogical University, Podchorążych 2, Kraków, 30-084, Poland Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Medicinal Chemistry, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków, 30-387, Poland Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, Madrid, 28006, Spain Cited By :7 Export Date: 15 February 2023 CODEN: BOCMB Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Medyczna 9, Poland; email: j.handzlik@uj.edu.pl Chemicals/CAS: tariquidar, 206873-63-4; verapamil, 152-11-4, 52-53-9; Antineoplastic Agents; imidazolidine-2,4-dione; Imidazolidines; Spiro Compounds Funding details: 23-27, N42/DBS/000027 Funding details: Consejo Superior de Investigaciones Científicas, CSIC, LINKA20285 Funding details: Narodowe Centrum Nauki, NCN, 17 - 22, DEC-2011/02/A/NZ4/00031, GINOP-2.3.2–15-2016–00038, UMO-2015/17/B/NZ7/02973 Funding details: Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie, UP, BN.610-185/PBU/2020 Funding text 1: The authors thank Mrs. Aleksandra Rodzik (Rybak), the master student at the Faculty of Pharmacy for her excellent participation in the synthesis, performed within the the Student Scientific Group of (Studenckie Koło Chemii Medycznej) at Jagiellonian University, Medical College in Cracow. This study was financially supported by Jagiellonian University Medical College in Cracow grant N42/DBS/000027 (synthesis of 6 - 16, 23-27 ), Pedagogical University of Cracow grant BN.610-185/PBU/2020 and Polish National Science Centre (NCN) grants: No UMO-2015/17/B/NZ7/02973 and DEC-2011/02/A/NZ4/00031 (synthesis of 17 - 22 ). The biological study was supported by the project GINOP-2.3.2–15-2016–00038 (Hungary). The Spanish-Polish-Hungarian collaboration was funded by CSIC through the iLINK project n° LINKA20285. Funding text 2: The authors thank Mrs. Aleksandra Rodzik (Rybak), the master student at the Faculty of Pharmacy for her excellent participation in the synthesis, performed within the the Student Scientific Group of (Studenckie Ko?o Chemii Medycznej) at Jagiellonian University, Medical College in Cracow. This study was financially supported by Jagiellonian University Medical College in Cracow grant N42/DBS/000027 (synthesis of 6-16, 23-27), Pedagogical University of Cracow grant BN.610-185/PBU/2020 and Polish National Science Centre (NCN) grants: No UMO-2015/17/B/NZ7/02973 and DEC-2011/02/A/NZ4/00031 (synthesis of 17-22). The biological study was supported by the project GINOP-2.3.2?15-2016?00038 (Hungary). The Spanish-Polish-Hungarian collaboration was funded by CSIC through the iLINK project n? LINKA20285. LA - English DB - MTMT ER - TY - JOUR AU - Ali, Wesam AU - Spengler, Gabriella AU - Kincses, Annamária AU - Nové, Márta AU - Battistelli, Cecilia AU - Latacz, Gniewomir AU - Starek, Małgorzata AU - Dąbrowska, Monika AU - Honkisz-Orzechowska, Ewelina AU - Romanelli, Annalisa AU - Rasile, Manuela Monica AU - Szymańska, Ewa AU - Jacob, Claus AU - Zwergel, Clemens AU - Handzlik, Jadwiga TI - Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 200 PY - 2020 PG - 17 SN - 0223-5234 DO - 10.1016/j.ejmech.2020.112435 UR - https://m2.mtmt.hu/api/publication/31315051 ID - 31315051 N1 - Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, Kraków, PL 30-688, Poland Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus B 2.1, Saarbruecken, D-66123, Germany Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Istituto Pasteur Italia, Fondazione Cenci-Bolognetti, Department of Molecular Medicine, “Department of Excellence 2018-2022”, Sapienza University of Rome, Viale Regina Elena 324, Rome, 00161, Italy Department of Inorganic Chemistry, Jagiellonian University, Medical College, Medyczna 9, Cracow, PL 30-688, Poland Department of Drug Chemistry and Technologies, “Department of Excellence 2018-2022”, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, 00185, Italy Department of Precision Medicine, “Luigi Vanvitelli” University of Campania, Via L. De Crecchio 7, Naples, 80138, Italy Cited By :21 Export Date: 8 February 2023 CODEN: EJMCA Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Medyczna 9, Poland; email: j.handzlik@uj.edu.pl Chemicals/CAS: cytochrome P450 3A4, 329736-03-0; doxorubicin, 23214-92-8, 25316-40-9; ketoconazole, 65277-42-1; verapamil, 152-11-4, 52-53-9; ABCB1 protein, human; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Ethers; Hydantoins; Organoselenium Compounds Funding details: Narodowe Centrum Nauki, NCN, N42/DBS/000027, UMO-2018/31/B/NZ7/02160 Funding details: Universität des Saarlandes, WT/2 e LFFP 16/01 Funding text 1: This study was financially supported by Polish National Science Centre (NCN) grants: No UMO-2018/31/B/NZ7/02160 (synthesis of compounds 14 – 17 ) and N42/DBS/000027 (synthesis of 5 – 13 ). Wesam Ali was financed by Saarland University , “Landesforschungsförderungsprogramm” (Grant No. WT/2 e LFFP 16/01 ) and he is thankful to the Erasmus+ program co-financing his research stay in Poland. C.Z is thankful for the generous financial support of the KOHR GmbH and the Sapienza Ateneo Project funding scheme . LA - English DB - MTMT ER - TY - JOUR AU - Baba, Yassir Filali AU - Misbahi, Houria AU - Rodi, Youssef Kandri AU - Ouzidan, Younes AU - Essassi, El Mokhtar AU - Vincze, Klaudia AU - Nové, Márta AU - Gajdács, Márió AU - Molnár, József AU - Spengler, Gabriella AU - Mazzah, Ahmed TI - 2-oxo-1,2-dihydroquinoline-4-carboxylic acid derivatives as potent modulators of ABCB1-related drug resistance of mouse T-lymphoma cells JF - CHEMICAL DATA COLLECTIONS J2 - CHEM DATA COLLECT VL - 29 PY - 2020 PG - 9 SN - 2405-8300 DO - 10.1016/j.cdc.2020.100501 UR - https://m2.mtmt.hu/api/publication/31392948 ID - 31392948 N1 - Acknowledgments: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0 0 01 ‘ National Excellence Program’. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Márió Gajdács and Gabriella Spengler received funding from the Márton Áron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. Márió Gajdács was supported by the ÚNKP-17-3 New National Excellence Program of the Ministry of Human Capaci- ties. The study was supported by the Szeged Foundation for Cancer Research. Laboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, Fez, BP 2202, Morocco Laboratory of Physical Chemistry and Bioorganic Chemistry, Faculty of Science and Technology, Hassan II University, BP 146, Mohammedia, 28800, Morocco Laboratory of Heterocyclic Organic Chemistry URAC21, Faculty of Sciences, University of Mohamed V, Rabat, Morocco Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary USR 3290 Miniaturisation pour l'analyse, la synthèse et la protéomique, Université Lille1, 59655 Villeneuve d'Ascq Cedex, France Export Date: 18 January 2021 Correspondence Address: Ouzidan, Y.; Laboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah UniversityMorocco; email: younes.ouzidan@fstm.ac.ma Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: European Social Fund, ESF Funding details: Magyar Tudományos Akadémia, MTA, 2017/18 Funding details: European Commission, EC Funding text 1: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘ National Excellence Program ’. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences . Márió Gajdács and Gabriella Spengler received funding from the Márton Áron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade . Márió Gajdács was supported by the ÚNKP-17-3 New National Excellence Program of the Ministry of Human Capacities . The study was supported by the Szeged Foundation for Cancer Research . LA - English DB - MTMT ER - TY - JOUR AU - Bús, Csaba AU - Kúsz, Norbert AU - Kincses, Annamária AU - Szemerédi, Nikoletta AU - Spengler, Gabriella AU - Bakacsy, László AU - Purger, Dragica AU - Berkecz, Róbert AU - Hohmann, Judit AU - Hunyadi, Attila AU - Vasas, Andrea TI - Antiproliferative Phenanthrenes from Juncus tenuis: Isolation and Diversity-Oriented Semisynthetic Modification JF - MOLECULES J2 - MOLECULES VL - 25 PY - 2020 IS - 24 PG - 14 SN - 1420-3049 DO - 10.3390/molecules25245983 UR - https://m2.mtmt.hu/api/publication/31783358 ID - 31783358 LA - English DB - MTMT ER - TY - JOUR AU - Dinić, J. AU - Efferth, T. AU - García-Sosa, A.T. AU - Grahovac, J. AU - Padrón, J.M. AU - Pajeva, I. AU - Rizzolio, F. AU - Saponara, S. AU - Spengler, Gabriella AU - Tsakovska, I. TI - Repurposing old drugs to fight multidrug resistant cancers JF - DRUG RESISTANCE UPDATES J2 - DRUG RESIST UPDATE VL - 52 PY - 2020 PG - 22 SN - 1368-7646 DO - 10.1016/j.drup.2020.100713 UR - https://m2.mtmt.hu/api/publication/31392313 ID - 31392313 N1 - Export Date: 31 July 2020 CODEN: DRUPF Correspondence Address: Padrón, J.M.; BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO AG), Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 2, Spain; email: jmpadron@ull.es Chemicals/CAS: abiraterone, 154229-19-3; artesunate, 82864-68-4, 88495-63-0; capecitabine, 154361-50-9; chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; dexamethasone, 50-02-2; docetaxel, 114977-28-5; hydralazine, 304-20-1, 86-54-4; hydroxychloroquine, 118-42-3, 525-31-5; itraconazole, 84625-61-6; lenalidomide, 191732-72-6; metformin, 1115-70-4, 657-24-9; niclosamide, 50-65-7; pomalidomide, 19171-19-8, 443912-23-0, 443919-33-3; prednisone, 53-03-2; rituximab, 174722-31-7; sorafenib, 284461-73-0; temozolomide, 85622-93-1; thalidomide, 50-35-1; valproic acid, 1069-66-5, 99-66-1; vorinostat, 149647-78-9 Funding details: Deutsche Krebshilfe, III41026 Funding details: Ministarstvo Prosvete, Nauke i TehnoloÅ¡kog Razvoja, MPNTR, 451-03-68/2020-14/200007 Funding details: PGC2018-094503-B-C22 Funding details: European Cooperation in Science and Technology, COST Funding details: Deutsche Forschungsgemeinschaft, DFG Funding details: Associazione Italiana per la Ricerca sul Cancro, AIRC Funding details: Deutsche Forschungsgemeinschaft, DFG Funding details: Ministarstvo Prosvete, Nauke i TehnoloÅ¡kog Razvoja, MPNTR Funding details: European Cooperation in Science and Technology, COST Funding text 1: This article is based upon work from COST Action CA17104 STRATAGEM - “New diagnostic and therapeutic tools against multidrug resistant tumors”, supported by COST (European Cooperation in Science and Technology) . JD acknowledges the financial support from The Ministry of Education, Science and Technological Development of the Republic of Serbia ( 451-03-68/2020-14/200007 ). TE acknowledges the grants from the German Research Foundation ( Deutsche Forschungsgemeinschaft ) and Germany Cancer Aid ( Deutsche Krebshilfe ) . ATG-S thanks Haridus- ja Teadusministeerium for grant IUT34-14 . JG is supported by Grant III41026 from the Serbian Ministry of Education, Science and Technological Development . JMP thanks the Spanish Government for financial support through project PGC2018-094503-B-C22 (MCIU/AEI/FEDER, UE) . IT acknowledges the financial support from the National Science Fund of Bulgaria (grant No. KP-06-COST/3/18.06.2019 ). FR acknowledges Fondazione AIRC per la Ricerca sul Cancro (grant No. IG23566 ). Cited By :5 Export Date: 18 January 2021 CODEN: DRUPF Correspondence Address: Padrón, J.M.; BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO AG), Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez 2, Spain; email: jmpadron@ull.es Chemicals/CAS: abiraterone, 154229-19-3; artesunate, 82864-68-4, 88495-63-0; capecitabine, 154361-50-9; chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; dexamethasone, 50-02-2; docetaxel, 114977-28-5; hydralazine, 304-20-1, 86-54-4; hydroxychloroquine, 118-42-3, 525-31-5; itraconazole, 84625-61-6; lenalidomide, 191732-72-6; metformin, 1115-70-4, 657-24-9; niclosamide, 50-65-7; pomalidomide, 19171-19-8, 443912-23-0, 443919-33-3; prednisone, 53-03-2; rituximab, 174722-31-7; sorafenib, 284461-73-0; temozolomide, 85622-93-1; thalidomide, 50-35-1; valproic acid, 1069-66-5, 99-66-1; vorinostat, 149647-78-9 Funding details: Deutsche Krebshilfe, III41026 Funding details: Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja, MPNTR, 451-03-68/2020-14/200007 Funding details: PGC2018-094503-B-C22 Funding details: KP-06-COST/3/18.06.2019 Funding details: European Cooperation in Science and Technology, COST Funding details: Deutsche Forschungsgemeinschaft, DFG Funding details: Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja, MPNTR Funding details: Associazione Italiana per la Ricerca sul Cancro, AIRC, IG23566 Funding details: Deutsche Forschungsgemeinschaft, DFG Funding text 1: This article is based upon work from COST Action CA17104 STRATAGEM - “New diagnostic and therapeutic tools against multidrug resistant tumors”, supported by COST (European Cooperation in Science and Technology) . JD acknowledges the financial support from The Ministry of Education, Science and Technological Development of the Republic of Serbia ( 451-03-68/2020-14/200007 ). TE acknowledges the grants from the German Research Foundation (Deutsche Forschungsgemeinschaft) and Germany Cancer Aid (Deutsche Krebshilfe) . ATG-S thanks Haridus- ja Teadusministeerium for grant IUT34-14 . JG is supported by Grant III41026 from the Serbian Ministry of Education, Science and Technological Development . JMP thanks the Spanish Government for financial support through project PGC2018-094503-B-C22 (MCIU/AEI/FEDER, UE) . IT acknowledges the financial support from the National Science Fund of Bulgaria (grant No. KP-06-COST/3/18.06.2019 ). FR acknowledges Fondazione AIRC per la Ricerca sul Cancro (grant No. IG23566 ). AB - Overcoming multidrug resistance represents a major challenge for cancer treatment. In the search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a tremendous interest during the past years. Repositioning candidates have often emerged through several stages of clinical drug development, and may even be marketed, thus attracting the attention and interest of pharmaceutical companies as well as regulatory agencies. Typically, drug repositioning has been serendipitous, using undesired side effects of small molecule drugs to exploit new disease indications. As bioinformatics gain increasing popularity as an integral component of drug discovery, more rational approaches are needed. Herein, we show some practical examples of in silico approaches such as pharmacophore modelling, as well as pharmacophore- and docking-based virtual screening for a fast and cost-effective repurposing of small molecule drugs against multidrug resistant cancers. We provide a timely and comprehensive overview of compounds with considerable potential to be repositioned for cancer therapeutics. These drugs are from diverse chemotherapeutic classes. We emphasize the scope and limitations of anthelmintics, antibiotics, antifungals, antivirals, antimalarials, antihypertensives, psychopharmaceuticals and antidiabetics that have shown extensive immunomodulatory, antiproliferative, pro-apoptotic, and antimetastatic potential. These drugs, either used alone or in combination with existing anticancer chemotherapeutics, represent strong candidates to prevent or overcome drug resistance. We particularly focus on outcomes and future perspectives of drug repositioning for the treatment of multidrug resistant tumors and discuss current possibilities and limitations of preclinical and clinical investigations. © 2020 Elsevier Ltd LA - English DB - MTMT ER - TY - CHAP AU - Stefkó, Dóra AU - Barta, Anita AU - Kúsz, Norbert AU - Berkecz, Róbert AU - Spengler, Gabriella AU - Annamária, Kincses AU - Bakacsy, László AU - Hohmann, Judit AU - Vasas, Andrea ED - Csiszár, Beáta ED - Hankó, Csilla ED - Kajos, Luca Fanni ED - Mező, Emerencia TI - Phytochemical and pharmacological investigation of sea rush T2 - Medical Conference for PhD Students and Experts of Clinical Sciences PB - University of Pécs, Doctoral Student Association CY - Pécs SN - 9789634295440 PY - 2020 SP - 57 PG - 1 UR - https://m2.mtmt.hu/api/publication/31670828 ID - 31670828 LA - English DB - MTMT ER - TY - JOUR AU - Dömötör, Orsolya AU - Kiss, Márton Attila AU - Gál, Gyula Tamás AU - May, Nóra Veronika AU - Spengler, Gabriella AU - Nové, Márta AU - Gašparović, Ana Čipak AU - Nagyné Frank, Éva AU - Enyedy, Éva Anna TI - Solution equilibrium, structural and cytotoxicity studies on Ru(η6-p-cymene) and copper complexes of pyrazolyl thiosemicarbazones JF - JOURNAL OF INORGANIC BIOCHEMISTRY J2 - J INORG BIOCHEM VL - 202 PY - 2020 PG - 13 SN - 0162-0134 DO - 10.1016/j.jinorgbio.2019.110883 UR - https://m2.mtmt.hu/api/publication/30858898 ID - 30858898 N1 - GINOP-2.3.2-15-2016-00038 LA - English DB - MTMT ER - TY - JOUR AU - Ferreira, Ricardo J. AU - Gajdács, Márió AU - Kincses, Annamária AU - Spengler, Gabriella AU - J. V. A. dos Santos, Daniel AU - Ferreira, Maria-José U. TI - Nitrogen-containing Naringenin Derivatives for Reversing Multidrug Resistance in Cancer JF - BIOORGANIC & MEDICINAL CHEMISTRY J2 - BIOORGAN MED CHEM VL - 28 PY - 2020 IS - 23 PG - 12 SN - 0968-0896 DO - 10.1016/j.bmc.2020.115798 UR - https://m2.mtmt.hu/api/publication/31619509 ID - 31619509 LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Nové, Márta AU - Csonka, Ákos AU - Varga, Borisz AU - SANMARTÍN, CARMEN AU - DOMÍNGUEZ-ÁLVAREZ, ENRIQUE AU - Spengler, Gabriella TI - Phenothiazines and Selenocompounds. A Potential Novel Combination Therapy of Multidrug Resistant Cancer TS - A Potential Novel Combination Therapy of Multidrug Resistant Cancer JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 40 PY - 2020 IS - 9 SP - 4921 EP - 4928 PG - 8 SN - 0250-7005 DO - 10.21873/anticanres.14495 UR - https://m2.mtmt.hu/api/publication/31564848 ID - 31564848 N1 - Export Date: 18 January 2021 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of SzegedHungary; email: spengler.gabriella@med.uszeged.hu Chemicals/CAS: chlorpromazine, 50-53-3, 69-09-0; promethazine, 58-33-3, 60-87-7; thioridazine, 130-61-0, 50-52-2; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Organoselenium Compounds; Phenothiazines Manufacturers: Sigma Aldrich Funding details: 3.6.3-VEKOP-16-2017-00009 Funding text 1: The study was supported by the Szeged Foundation for Cancer Research (Szegedi Rákkutatásért Alapítvány). M.N. was supported by EFOP 3.6.3-VEKOP-16-2017-00009. E.D.A. was supported by ‘Iniciativas Ropelanas’ and ‘Asociación Cultural Trevinca’, two associations from Zamora (Spain) that promote cancer research. Cited By :1 Export Date: 3 June 2021 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Hungary; email: spengler.gabriella@med.uszeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Kaczor, Aneta AU - Nové, Márta AU - Kincses, Annamária AU - Spengler, Gabriella AU - Szymańska, Ewa AU - Latacz, Gniewomir AU - Handzlik, Jadwiga TI - Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance JF - MOLECULES J2 - MOLECULES VL - 25 PY - 2020 IS - 9 PG - 24 SN - 1420-3049 DO - 10.3390/molecules25092258 UR - https://m2.mtmt.hu/api/publication/31314654 ID - 31314654 N1 - Funding Agency and Grant Number: Ministry of Science and Higher EducationMinistry of Science and Higher Education, Poland [0169/DIA/2017/46]; Jagiellonian University Medical College [N42/DBS/000070, N42/DBS/000027]; [EFOP 3.6.3-VEKOP-16-2017-00009] Funding text: This research was funded from Ministry of Science and Higher Education budget funds for science in 2017-2020, as a research project within "Diamond grant" no. 0169/DIA/2017/46 and Jagiellonian University Medical College grants, grant number N42/DBS/000070 and N42/DBS/000027. M.N. was supported by EFOP 3.6.3-VEKOP-16-2017-00009. Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, Kraków, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Export Date: 31 July 2020 CODEN: MOLEF Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, Poland; email: j.handzlik@uj.edu.pl Funding details: 3.6.3-VEKOP-16-2017-00009 Funding details: Uniwersytet JagielloÅski Collegium Medicum, N42/DBS/000070, N42/DBS/000027 Funding details: Ministerstwo Nauki i Szkolnictwa Wyższego, MNiSW, 0169/DIA/2017/46 Funding text 1: Funding: This research was funded from Ministry of Science and Higher Education budget funds for science in 2017–2020, as a research project within “Diamond grant” no. 0169/DIA/2017/46 and Jagiellonian University Medical College grants, grant number N42/DBS/000070 and N42/DBS/000027. M.N. was supported by EFOP 3.6.3-VEKOP-16-2017-00009. Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, Kraków, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Cited By :1 Export Date: 18 January 2021 CODEN: MOLEF Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, Poland; email: j.handzlik@uj.edu.pl Funding details: 3.6.3-VEKOP-16-2017-00009 Funding details: Uniwersytet Jagielloński Collegium Medicum, N42/DBS/000070, N42/DBS/000027 Funding details: 0169/DIA/2017/46 Funding text 1: Funding: This research was funded from Ministry of Science and Higher Education budget funds for science in 2017–2020, as a research project within “Diamond grant” no. 0169/DIA/2017/46 and Jagiellonian University Medical College grants, grant number N42/DBS/000070 and N42/DBS/000027. M.N. was supported by EFOP 3.6.3-VEKOP-16-2017-00009. LA - English DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Szabó, Stefánia AU - Rácz, Bálint AU - Szemerédi, Nikoletta AU - Watanabe, Genki AU - Saijo, Ryosuke AU - Sekiya, Hiroshi AU - Tamai, Eiji AU - Molnár, József AU - Kawase, Masami AU - Spengler, Gabriella TI - Benzoxazole-Based Metal Complexes to Reverse Multidrug Resistance in Bacteria JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 9 PY - 2020 IS - 10 PG - 12 SN - 2079-6382 DO - 10.3390/antibiotics9100649 UR - https://m2.mtmt.hu/api/publication/31612933 ID - 31612933 N1 - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, 790-8578, Japan Department of Infectious Diseases, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, 790-8578, Japan Cited By :10 Export Date: 19 June 2023 Correspondence Address: Kincses, A.; Department of Medical Microbiology and Immunobiology, Dóm tér 10, Hungary; email: kincses.annamaria@med.u-szeged.hu Chemicals/CAS: ciprofloxacin, 85721-33-1; copper, 15158-11-9, 7440-50-8; dimethyl sulfoxide, 67-68-5; ethidium bromide, 1239-45-8; ferric ion, 20074-52-6; glutamine, 56-85-9, 6899-04-3; magnesium, 7439-95-4; nickel, 7440-02-0; nystatin, 1400-61-9, 34786-70-4, 62997-67-5; promethazine, 58-33-3, 60-87-7; pyruvic acid, 127-17-3, 19071-34-2, 57-60-3; silver, 7440-22-4; streptomycin, 57-92-1; verapamil, 152-11-4, 52-53-9; zinc, 7440-66-6, 14378-32-6 Tradenames: LightCycler 1.5 pcr system, Hoffmann La Roche, United States; Multiscan EX ELISA reader, Thermo Labsystems, United States; thermal Cycler pcr system, Hoffmann La Roche, United States Manufacturers: Hoffmann La Roche, United States; Thermo Labsystems, United States Funding text 1: This research was funded by the project GINOP-2.3.2-15-2016-00038 (Hungary). supported by the Nation?s Young Talent Scholarship (Nemzet Fiatal Tehets?gei?rt ?szt?nd?j). The study was. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Dávid AU - Igaz, Nóra AU - Marton, Annamária AU - Rónavári, Andrea AU - Bélteky, Péter AU - Bodai, László AU - Spengler, Gabriella AU - Tiszlavicz, László AU - Rázga, Zsolt AU - Hegyi, Péter AU - Vizler, Csaba AU - Boros, Imre Miklós AU - Kónya, Zoltán AU - Csontné Kiricsi, Mónika TI - Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts JF - JOURNAL OF NANOBIOTECHNOLOGY J2 - J NANOBIOTECHNOL VL - 18 PY - 2020 IS - 1 PG - 19 SN - 1477-3155 DO - 10.1186/s12951-020-0576-x UR - https://m2.mtmt.hu/api/publication/31138211 ID - 31138211 N1 - GINOP-2.3.2-15-2016-00038 GINOP-2.3.2-15-2016-00020 LA - English DB - MTMT ER - TY - JOUR AU - Małgorzata, Anna Marć AU - Kincses, Annamária AU - Rácz, Bálint AU - Muhammad, Jawad Nasim AU - Muhammad, Sarfraz AU - Carlos, Lázaro-Milla AU - Enrique, Domínguez-Álvarez AU - Claus, Jacob AU - Spengler, Gabriella AU - Pedro, Almendros TI - Antimicrobial, Anticancer and Multidrug-Resistant Reversing Activity of Novel Oxygen-, Sulfur- and Selenoflavones and Bioisosteric Analogues JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 13 PY - 2020 IS - 12 PG - 11 SN - 1424-8247 DO - 10.3390/ph13120453 UR - https://m2.mtmt.hu/api/publication/31749584 ID - 31749584 N1 - Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, H-6720, Hungary Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Saarbruecken, D-66123, Germany Grupo de Lactamas y Heterociclos Bioactivos, Unidad Asociada al CSIC, Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Madrid, E-28040, Spain Instituto de Química Orgánica General IQOG-CSIC, Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, Madrid, 28006, Spain Export Date: 18 January 2021 Correspondence Address: Marć, M.A.; Department of Medical Microbiology and Immunobiology, University of SzegedHungary; email: marcmalgorzata@gmail.com Chemicals/CAS: verapamil, 152-11-4, 52-53-9 Funding details: Comisión Sectorial de Investigación Científica, CSIC, LINKA20285 Funding details: University of Central Missouri, UCM, GINOP-2.3.2–15-2016–00038 Funding details: Australian Education International, Australian Government, AEI Funding details: European Regional Development Fund, FEDER, PGC2018-095025-B-I00 Funding text 1: Funding: This research was funded by AEI (MICIU) and FEDER (Project PGC2018-095025-B-I00). C.L.-M. thanks to MICIU and UCM for a postdoctoral contract. Experiments performed in Hungary were supported by GINOP-2.3.2–15-2016–00038 (Hungary). The authors would like to thank University of Saarland (Germany) for financial support. The Spanish–Hungarian collaboration was funded by CSIC through the iLINK project nº LINKA20285. LA - English DB - MTMT ER - TY - CHAP AU - Gajdács, Márió AU - Spengler, Gabriella TI - Non-Antibiotic Pharmaceuticals as Quorum Sensing Inhibitors: Results from a Disk Diffusion-Based In Vitro Study T2 - 21st Iinternational Medical Esperanto Congress: COVID-19 pandemic : history, current status and consequences PB - Zakład Optymalizacji Zawodowej Ośrodek Umea Shinoda-Kuracejo CY - Krakow SN - 9788394612450 PY - 2020 PG - 1 UR - https://m2.mtmt.hu/api/publication/31386114 ID - 31386114 LA - English DB - MTMT ER - TY - CONF AU - Gajdács, Márió AU - Spengler, Gabriella TI - Drug repositioning as a possible strategy to combat bacterial infections: evaluation of non-antibiotic human therapeutics as quorum-sensing inhibitors T2 - 30th European Congress of Clinical Microbiology and Infectious Diseases: Abstract Book 2020 PB - European Society of Clinical Microbiology and Infectious Diseases (ESCMID) PY - 2020 SP - 1115 EP - 1115 PG - 1 UR - https://m2.mtmt.hu/api/publication/31303690 ID - 31303690 LA - English DB - MTMT ER - TY - JOUR AU - Mészáros, János Péter AU - Poljarević, Jelena AU - Szatmári, István AU - Csuvik, Oszkár AU - Fülöp, Ferenc AU - Szoboszlai, Norbert AU - Spengler, Gabriella AU - Enyedy, Éva Anna TI - An 8-hydroxyquinoline-proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes JF - JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS J2 - J CHEM SOC DALTON TRANS VL - 49 PY - 2020 IS - 23 SP - 7977 EP - 7992 PG - 16 SN - 1472-7773 DO - 10.1039/d0dt01256d UR - https://m2.mtmt.hu/api/publication/31313563 ID - 31313563 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office-NKFIA [GINOP-2.3.2-15-2016-00038, FK 124240]; FIKP program [TUDFO/47138-1/2019-ITM]; National Excellence Program of the Ministry for Innovation and Technology [UNKP-19-3] Funding text: This work was supported by the National Research, Development and Innovation Office-NKFIA through projects GINOP-2.3.2-15-2016-00038, FK 124240 and FIKP program TUDFO/47138-1/2019-ITM. J. P. M. acknowledges the support of the UNKP-19-3 National Excellence Program of the Ministry for Innovation and Technology. LA - English DB - MTMT ER - TY - JOUR AU - Milunović, Miljan N. M. AU - Palamarciuc, Oleg AU - Sirbu, Angela AU - Shova, Sergiu AU - Dumitrescu, Dan AU - Dvoranová, Dana AU - Rapta, Peter AU - Petrasheuskaya, Tatsiana AU - Enyedy, Éva Anna AU - Spengler, Gabriella AU - Ilic, Marija AU - Sitte, Harald H. AU - Lubec, Gert AU - Arion, Vladimir B. TI - Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters JF - BIOMOLECULES J2 - BIOMOLECULES VL - 10 PY - 2020 IS - 9 SP - 1213 PG - 30 SN - 2218-273X DO - 10.3390/biom10091213 UR - https://m2.mtmt.hu/api/publication/31407523 ID - 31407523 N1 - Funding Agency and Grant Number: Austrian Science Fund (FWF)Austrian Science Fund (FWF) [P28223]; Hungarian National Research, Development and Innovation Office-NKFIA [FK 124240]; COST Action, NECTAR-Network for Equilibria and Chemical Thermodynamics Advanced Research supported by COST (European Cooperation in Science and Technology) [CA18202]; FIKP program (Hungary) [TUDFO/47138-1/2019-ITM, GINOP-2.3.2-15-2016-00038]; Slovak Grant Agency APVVSlovak Research and Development Agency [APVV-15-0053, APVV-19-0024, DS-FR-19-0035]; Slovak Grant Agency VEGAVedecka grantova agentura MSVVaS SR a SAV (VEGA) [1/0504/20, 1/0466/18]; OeAD [SK18/2018] Funding text: This work was supported by the Austrian Science Fund (FWF grant no. P28223) and Hungarian National Research, Development and Innovation Office-NKFIA through project FK 124240 and FIKP program TUDFO/47138-1/2019-ITM and GINOP-2.3.2-15-2016-00038 (Hungary). This article is also based upon work from COST Action CA18202, NECTAR-Network for Equilibria and Chemical Thermodynamics Advanced Research supported by COST (European Cooperation in Science and Technology). This work received financial support from Slovak Grant Agencies APVV (contract Nos. APVV-15-0053, APVV-19-0024 and DS-FR-19-0035) and VEGA (contracts No. 1/0504/20, 1/0466/18). The support of OeAD by travel grant SK18/2018 is also acknowledged. LA - English DB - MTMT ER - TY - JOUR AU - Nové, Márta AU - Kincses, Annamária AU - Szalontai, Beatrix AU - Rácz, Bálint AU - Blair, Jessica M. A. AU - González-Prádena, Ana AU - Benito-Lama, Miguel AU - Domínguez-Álvarez, Enrique AU - Spengler, Gabriella TI - Biofilm Eradication by Symmetrical Selenoesters for Food-Borne Pathogens JF - MICROORGANISMS J2 - MICROORGANISMS VL - 8 PY - 2020 IS - 4 PG - 15 SN - 2076-2607 DO - 10.3390/microorganisms8040566 UR - https://m2.mtmt.hu/api/publication/31281334 ID - 31281334 N1 - Funding: The study was supported by the projects SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine and GINOP-2.3.2-15-2016-00038 (Hungary). M.N. was supported by EFOP 3.6.3-VEKOP-16-2017-00009. E.D-A. was supported by ‘Iniciativas Ropelanas’ and ‘Asociación Cultural Trevinca’,two associations from Zamora (Spain), that promote cancer research. LA - English DB - MTMT ER - TY - JOUR AU - Nové, Márta AU - Kincses, Annamária AU - Molnár, József AU - Amaral, Leonard AU - Spengler, Gabriella TI - The Role of Efflux Pumps and Environmental pH in Bacterial Multidrug Resistance JF - IN VIVO J2 - IN VIVO VL - 34 PY - 2020 IS - 1 SP - 65 EP - 71 PG - 7 SN - 0258-851X DO - 10.21873/invivo.11746 UR - https://m2.mtmt.hu/api/publication/31033042 ID - 31033042 N1 - Acknowledgements: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’ and EFOP 3.6.3-VEKOP-16-2017-00009 and the János Bolyai Research Scholarship of the Hungarian Academy of HungarySciences. Annamária Kincses was supported by the ÚNKP-18-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. Funding Agency and Grant Number: European UnionEuropean Union (EU); European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.4. A/2-11-1-2012-0001, EFOP 3.6.3-VEKOP-16-2017-00009]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; New National Excellence Program of the Ministry of Human Capacities of Hungary [UNKP-18-3]; State of Hungary Funding text: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TAMOP 4.2.4. A/2-11-1-2012-0001 'National Excellence Program' and EFOP 3.6.3-VEKOP-16-2017-00009 and the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamaria Kincses was supported by the UNKP-18-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. Travel Medicine, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, Portugal Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Cited By :1 Export Date: 31 July 2020 CODEN: IVIVE Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Hungary; email: spengler.gabriella@med.u-szeged.hu Chemicals/CAS: glycerol 3 phosphate dehydrogenase, 9001-49-4; promethazine, 58-33-3, 60-87-7; carrier protein, 80700-39-6; AcrB protein, E coli; Escherichia coli Proteins; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins Funding details: European Social Fund, ESF, EFOP 3.6.3-VEKOP-16-2017-00009, A/2-11-1-2012-0001 Funding details: European Commission, EC Funding details: Magyar Tudományos Akadémia, MTA, NKP-18-3 Funding text 1: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of T?MOP 4.2.4. A/2-11-1-2012-0001 'National Excellence Program' and EFOP 3.6.3-VEKOP-16-2017-00009 and the J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annam?ria Kincses was supported by the ?NKP-18-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. Travel Medicine, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, Portugal Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Cited By :1 Export Date: 18 January 2021 CODEN: IVIVE Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Hungary; email: spengler.gabriella@med.u-szeged.hu Chemicals/CAS: glycerol 3 phosphate dehydrogenase, 9001-49-4; promethazine, 58-33-3, 60-87-7; carrier protein, 80700-39-6; AcrB protein, E coli; Escherichia coli Proteins; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins Funding details: European Social Fund, ESF, EFOP 3.6.3-VEKOP-16-2017-00009, A/2-11-1-2012-0001 Funding details: Magyar Tudományos Akadémia, MTA, NKP-18-3 Funding details: European Commission, EC Funding text 1: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of T?MOP 4.2.4. A/2-11-1-2012-0001 'National Excellence Program' and EFOP 3.6.3-VEKOP-16-2017-00009 and the J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annam?ria Kincses was supported by the ?NKP-18-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. LA - English DB - MTMT ER - TY - JOUR AU - Petrasheuskaya, Tatsiana AU - Kiss, Márton Attila AU - Dömötör, Orsolya AU - Holczbauer, Tamás AU - May, Nóra Veronika AU - Spengler, Gabriella AU - Kincses, Annamária AU - Čipak Gašparović, Ana AU - Nagyné Frank, Éva AU - Enyedy, Éva Anna TI - Salicylaldehyde thiosemicarbazone copper complexes: impact of hybridization with estrone on cytotoxicity, solution stability and redox activity JF - NEW JOURNAL OF CHEMISTRY J2 - NEW J CHEM VL - 44 PY - 2020 IS - 28 SP - 12154 EP - 12168 PG - 15 SN - 1144-0546 DO - 10.1039/d0nj01070g UR - https://m2.mtmt.hu/api/publication/31367278 ID - 31367278 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office-NKFIA [GINOP-2.3.2-15-2016-00038, FK 124240, PD 128504, TUDFO/47138-1/2019-ITM]; J. Bolyai Research Scholarship of the Hungarian Academy of Sciences; Visegrad Scholarship [51910905]; COST (European Cooperation in Science and Technology)European Cooperation in Science and Technology (COST) [CA17104] Funding text: This work was supported by National Research, Development and Innovation Office-NKFIA through projects GINOP-2.3.2-15-2016-00038, FK 124240, PD 128504, FIKP program TUDFO/47138-1/2019-ITM, J. Bolyai Research Scholarship of the Hungarian Academy of Sciences (T. H., N. V. M.), Visegrad Scholarship 51910905 (T. V. P.). This article is also based upon work from COST Action CA17104 supported by COST (European Cooperation in Science and Technology). LA - English DB - MTMT ER - TY - JOUR AU - Szczepańska, K. AU - Kincses, Annamária AU - Vincze, K. AU - Szymańska, E. AU - Latacz, G. AU - Kuder, K.J. AU - Stark, H. AU - Spengler, Gabriella AU - Handzlik, J. AU - Kieć-Kononowicz, K. TI - N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins JF - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS J2 - BIOORG MED CHEM LETT VL - 30 PY - 2020 IS - 22 PG - 5 SN - 0960-894X DO - 10.1016/j.bmcl.2020.127522 UR - https://m2.mtmt.hu/api/publication/31856961 ID - 31856961 N1 - Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University Düsseldorf, Universitaetsstr. 1, Düsseldorf, 40225, Germany Export Date: 9 February 2021 CODEN: BMCLE Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Medyczna 9, Poland; email: j.handzlik@uj.edu.pl AB - Taking into account that multidrug resistance (MDR) is the main cause for chemotherapeutic failure in cancer treatment, the ability of novel histamine H3 receptor ligands to reverse the cancer MDR was evaluated, using the ABCB1 efflux pump inhibition assay in mouse MDR T-lymphoma cells. The most active compounds displayed significant cytotoxic and antiproliferative effects as well as a very potent MDR efflux pump inhibitory action, 3–5-fold stronger than that of reference inhibitor verapamil. Although these compounds possess weak antagonistic properties against histamine H3 receptors, they are valuable pharmacological tools in the search for novel anticancer molecules. Furthermore, for the most active compounds, an insight into mechanisms of action using either, the luminescent Pgp-Glo™ Assay in vitro or docking studies to human Pgp, was performed. © 2020 Elsevier Ltd LA - English DB - MTMT ER - TY - JOUR AU - Szemerédi, Nikoletta AU - Kincses, Annamária AU - Rehorova, Katerina AU - Hoang, Lan AU - Salardón-Jiménez, Noemi AU - Sevilla-Hernández, Clotilde AU - Viktorová, Jitka AU - Domínguez-Álvarez, Enrique AU - Spengler, Gabriella TI - Ketone- and Cyano-Selenoesters to Overcome Efflux Pump, Quorum-Sensing, and Biofilm-Mediated Resistance JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 9 PY - 2020 IS - 12 PG - 17 SN - 2079-6382 DO - 10.3390/antibiotics9120896 UR - https://m2.mtmt.hu/api/publication/31780199 ID - 31780199 N1 - Funding Agency and Grant Number: University of Szeged, Faculty of Medicine [SZTE AOK-KKA 2018/270-62-2]; Consejo Superior de Investigaciones Cientificas (CSIC, Spain) [LINKA20285]; Czech Ministry of Education, Youth and Sports INTER-COST [LTC19007]; COST Action [CA17104 STRATAGEM]; [GINOP-2.3.2-15-2016-00038] Funding text: The study was supported by the projects SZTE AOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine and GINOP-2.3.2-15-2016-00038 (Hungary); Consejo Superior de Investigaciones Cientificas (CSIC, Spain, project LINKA20285); and Czech Ministry of Education, Youth and Sports INTER-COST LTC19007, COST Action CA17104 STRATAGEM. LA - English DB - MTMT ER - TY - JOUR AU - Vágvölgyi, Máté AU - Bélteky, Péter AU - Bogdán, Dóra AU - Nové, Márta AU - Spengler, Gabriella AU - Latif, Ahmed Dhahir AU - Zupkó, István AU - Gáti, Tamás AU - Tóth, Gábor AU - Kónya, Zoltán AU - Hunyadi, Attila TI - Squalenoylated Nanoparticle Pro-Drugs of Adjuvant Antitumor 11α-Hydroxyecdysteroid 2,3-Acetonides Act as Cytoprotective Agents Against Doxorubicin and Paclitaxel JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 11 PY - 2020 PG - 14 SN - 1663-9812 DO - 10.3389/fphar.2020.552088 UR - https://m2.mtmt.hu/api/publication/31602087 ID - 31602087 N1 - Institute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary Department of Applied and Environmental Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary Department of Organic Chemistry, Semmelweis University, Budapest, Hungary Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Budapest, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary Servier Research Institute of Medicinal Chemistry (SRIMC), Budapest, Hungary NMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Hungary MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, University of Szeged, Szeged, Hungary Export Date: 21 October 2020 Correspondence Address: Hunyadi, A.; Institute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Interdisciplinary Centre for Natural Products, University of SzegedHungary; email: hunyadi.a@pharm.u-szeged.hu Institute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary Department of Applied and Environmental Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary Department of Organic Chemistry, Semmelweis University, Budapest, Hungary Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Budapest, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary Servier Research Institute of Medicinal Chemistry (SRIMC), Budapest, Hungary NMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Hungary MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, University of Szeged, Szeged, Hungary Export Date: 22 October 2020 Correspondence Address: Hunyadi, A.; Institute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Interdisciplinary Centre for Natural Products, University of SzegedHungary; email: hunyadi.a@pharm.u-szeged.hu Institute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary Department of Applied and Environmental Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Szeged, Hungary Department of Organic Chemistry, Semmelweis University, Budapest, Hungary Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Budapest, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary Servier Research Institute of Medicinal Chemistry (SRIMC), Budapest, Hungary NMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Budapest, Hungary MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, University of Szeged, Szeged, Hungary Export Date: 2 November 2020 Correspondence Address: Hunyadi, A.; Institute of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Interdisciplinary Centre for Natural Products, University of SzegedHungary; email: hunyadi.a@pharm.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Andrea AU - Kincses, Annamária AU - Nové, Márta AU - Zsófia, Vadas AU - Carmen, Sanmartín AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella TI - Selenoesters and Selenoanhydrides as Novel Agents Against Resistant Breast Cancer JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 39 PY - 2019 IS - 7 SP - 3777 EP - 3783 PG - 7 SN - 0250-7005 DO - 10.21873/anticanres.13526 UR - https://m2.mtmt.hu/api/publication/30706172 ID - 30706172 N1 - Acknowledgements: The study was also supported by the grant EFOP 3.6.3-VEKOP-16-2017-00009 of the Ministry of Human Capacities of the Government of Hungary. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Enrique Domínguez-Álvarez had financial support from the Consejo Superior de Investigaciones Científicas (Grant 201780I027). Carmen Sanmartín was funded by Uned Pamplona, by Fundación Bancaria “La Caixa” and by Fundación Caja Navarra. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain Institute of General Organic Chemistry, Spanish National Research Council (IQOG-CSIC), Madrid, Spain Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Export Date: 22 August 2019 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Hungary; email: spengler.gabriella@med.u-szeged.hu Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; Anhydrides; Antineoplastic Agents; Doxorubicin; Esters; Selenium Compounds Funding details: Consejo Superior de Investigaciones Científicas, CSIC Funding details: Universidad de Navarra Funding details: Health Research, HRI Funding details: “la Caixa” Foundation Funding details: Fundación Caja Navarra Funding details: Magyar Tudományos Akadémia, MTA Funding details: Consejo Superior de Investigaciones Científicas, CSIC, 201780I027 Funding text 1: 1Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary; 2Department of Obstetrics and Gynecology, Faculty of Medicine, University of Szeged, Szeged, Hungary; 3Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain; 4Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain; 5Institute of General Organic Chemistry, Spanish National Research Council (IQOG-CSIC), Madrid, Spain Funding text 2: The study was also supported by the grant EFOP 3.6.3-VEKOP-16-2017-00009 of the Ministry of Human Capacities of the Government of Hungary. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Enrique Domínguez-Álvarez had financial support from the Consejo Superior de Investigaciones Científicas (Grant 201780I027). Carmen Sanmartín was funded by Uned Pamplona, by Fundación Bancaria “La Caixa” and by Fundación Caja Navarra. Funding Agency and Grant Number: Ministry of Human Capacities of the Government of Hungary [EFOP 3.6.3-VEKOP-16-2017-00009]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; Consejo Superior de Investigaciones Cientificas [201780I027]; Uned Pamplona; Fundacion Bancaria "La Caixa"; Fundacion Caja Navarra Funding text: The study was also supported by the grant EFOP 3.6.3-VEKOP-16-2017-00009 of the Ministry of Human Capacities of the Government of Hungary. Gabriella Spengler was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Enrique Dominguez-Alvarez had financial support from the Consejo Superior de Investigaciones Cientificas (Grant 201780I027). Carmen Sanmartin was funded by Uned Pamplona, by Fundacion Bancaria "La Caixa" and by Fundacion Caja Navarra. LA - English DB - MTMT ER - TY - GEN AU - Kincses, Annamária AU - Enrique, Domínguez-Álvarez AU - Carmen, Sanmartín AU - Helen, E. Smith AU - Jessica, M. A. Blair AU - Nové, Márta AU - Spengler, Gabriella TI - Biofilm inhibiting activity of selenium compounds PY - 2019 UR - https://m2.mtmt.hu/api/publication/30807017 ID - 30807017 LA - English DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Orsolya, Vásárhelyi AU - Nové, Márta AU - Zsoldiné Urbán, Edit AU - Spengler, Gabriella TI - THE ROLE OF PH REGARDING ANTIBIOTIC SUSCEPTIBILITY OF URINARY TRACT PATHOGENS JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - Suppl.1. PY - 2019 IS - 66. SP - 49 EP - 50 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/30734143 ID - 30734143 LA - English DB - MTMT ER - TY - JOUR AU - Bacher, Felix AU - Wittmann, Christopher AU - Nové, Márta AU - Spengler, Gabriella AU - Marć, Małgorzata Anna AU - Enyedy, Éva Anna AU - Darvasiova, Denisa AU - Rapta, P. AU - Reiner, Thomas AU - Arion, Vladimir TI - Novel latonduine derived proligands and their copper(II) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity JF - JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS J2 - J CHEM SOC DALTON TRANS VL - 48 PY - 2019 IS - 28 SP - 10464 EP - 10478 PG - 15 SN - 1472-7773 DO - 10.1039/c9dt01238a UR - https://m2.mtmt.hu/api/publication/30671750 ID - 30671750 N1 - Acknowledgements: This work was supported by the Austrian Science Fund (FWF) via the Grant no. P31293-N37. EAE acknowledges the support by National Research, Development and Innovation Office-NKFIA through project FK 124240 and Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT. The study was also supported by the project GINOP-2.3.2-15-2016-00038 of the University of Szeged. We thank Alexander Roller for the X-ray data collection. This work was also supported by the Science and Technology Assistance Agency under the contract no. APVV-15-0053 and SK-AT-2017-0017, and by the Slovak Grant Agency VEGA under contract no. 1/0416/17 and 1/0466/18. TR acknowledges the support of this work by National Institutes of Health via the grant P30 CA00874. LA - English DB - MTMT ER - TY - JOUR AU - ČIŽMÁRIKOVÁ, MARTINA AU - TAKÁČ, PETER AU - Spengler, Gabriella AU - Kincses, Annamária AU - Nové, Márta AU - VILKOVÁ, MÁRIA AU - MOJŽIŠ, JÁN TI - New Chalcone Derivative Inhibits ABCB1 in Multidrug Resistant T-cell Lymphoma and Colon Adenocarcinoma Cells JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 39 PY - 2019 IS - 12 SP - 6499 EP - 6505 PG - 7 SN - 0250-7005 DO - 10.21873/anticanres.13864 UR - https://m2.mtmt.hu/api/publication/30981329 ID - 30981329 N1 - Department of Pharmacology, Faculty of Medicine, University of Pavol Jozef Safarik, Trieda SNP 1, Kosice, 040 11, Slovakia Institute of Human and Clinical Pharmacology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, Kosice, 041 81, Slovakia Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Department of Organic Chemistry, Faculty of Science, University of Pavol Jozef Safarik, Kosice, Slovakia Cited By :10 Export Date: 9 February 2023 CODEN: ANTRD Correspondence Address: Čižmáriková, M.; Department of Pharmacology, Trieda SNP 1, Slovakia; email: martina.cizmarikova@upjs.sk Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; rhodamine 123, 62669-70-9; verapamil, 152-11-4, 52-53-9; ABCB1 protein, human; ATP Binding Cassette Transporter, Subfamily B; Chalcones; Doxorubicin Funding details: Agentúra na Podporu Výskumu a Vývoja, APVV, APVV-16-0446 Funding text 1: This study was supported by the project GINOP-2.3.2-15-2016-00012 (Hungary) and the Slovak Research and Development Agency under the contract No. APVV-16-0446. LA - English DB - MTMT ER - TY - JOUR AU - Domínguez‐Álvarez, Enrique AU - Łażewska, Dorota AU - Szabó, Zsanett AU - Hagenow, Stefanie AU - Reiner, David AU - Gajdács, Márió AU - Spengler, Gabriella AU - Stark, Holger AU - Handzlik, Jadwiga AU - Kieć‐Kononowicz, Katarzyna TI - The Search for Histamine H 4 Receptor Ligands with Anticancer Activity among Novel (Thio)urea Derivatives JF - CHEMISTRYSELECT J2 - CHEMISTRYSELECT VL - 4 PY - 2019 IS - 36 SP - 10943 EP - 10952 PG - 10 SN - 2365-6549 DO - 10.1002/slct.201902747 UR - https://m2.mtmt.hu/api/publication/30826705 ID - 30826705 N1 - Funding Agency and Grant Number: National Science Center Poland [DEC-2011/02/A/NZ4/00031]; Szeged Foundation for Cancer Research; European UnionEuropean Union (EU); State of Hungary; European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.4. A/2-11-12012-0001]; Janos Bolyai Research scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences Funding text: The authors are grateful to Mrs. Aniko Varadi Vigyikan for laboratory work and assistance. This work was partly supported by National Science Center Poland grant no. DEC-2011/02/A/NZ4/00031, the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TAMOP 4.2.4. A/2-11-12012-0001 'National Excellence Program'. This paper was also supported by the Janos Bolyai Research scholarship of the Hungarian Academy of Sciences. Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, Madrid, 28006, Spain Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, Kraków, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, Düsseldorf, 40225, Germany Cited By :1 Export Date: 31 July 2020 Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Funding details: DEC‐2011/02/A/NZ4/00031 Funding details: European Social Fund, ESF Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Commission, EC Funding text 1: The authors are grateful to Mrs. Anikó Váradi Vigyikán for laboratory work and assistance. This work was partly supported by National Science Center Poland grant no. DEC‐2011/02/A/NZ4/00031 , the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, co‐financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2‐11‐1‐2012‐0001 ‘National Excellence Program’. This paper was also supported by the János Bolyai Research scholarship of the Hungarian Academy of Sciences . Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, Madrid, 28006, Spain Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, Kraków, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstraße 1, Düsseldorf, 40225, Germany Cited By :2 Export Date: 18 January 2021 Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Funding details: European Social Fund, ESF, A/2‐11‐1‐2012‐0001 Funding details: Magyar Tudományos Akadémia, MTA, DEC‐2011/02/A/NZ4/00031 Funding details: European Commission, EC Funding text 1: . The authors are grateful to Mrs. Anikó Váradi Vigyikán for laboratory work and assistance. This work was partly supported by National Science Center Poland grant no. , the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, co‐financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2‐11‐1‐2012‐0001 ‘National Excellence Program’. This paper was also supported by the János Bolyai Research scholarship of the Hungarian Academy of Sciences DEC‐2011/02/A/NZ4/00031 LA - English DB - MTMT ER - TY - CONF AU - Dömötör, Orsolya AU - Tatsiana, Petrasheuskaya AU - Gál, G. Tamás AU - May, Nóra Veronika AU - Nové, Márta AU - Kincses, Annamária AU - Spengler, Gabriella AU - Ana, Čipak Gašparović AU - Kiss, Márton Attila AU - Nagyné Frank, Éva AU - Enyedy, Éva A. TI - Pirazolo- és szaliciladehid-tioszemikarbazon ligandumok Cu(II) és Ru(II)(p-cimol) komplexei: szintézis, rákellenes aktivitás, stabilitás és szerkezet T2 - 53. Komplexkémiai Kollokvium Az MKE Komplexkémiai Szakcsoportjának és az MTA Koordinációs Kémiai Munkabizottságának a rendezvénye Részletes programfüzet, Előadás-összefoglalók PY - 2019 SP - E6 UR - https://m2.mtmt.hu/api/publication/32893957 ID - 32893957 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Duca, Gheorghe AU - Aricu, Aculina AU - Kuchkova, Kaleria AU - Secara, Elena AU - Barba, Alic AU - Dragalin, Ion AU - Ungur, Nicon AU - Spengler, Gabriella TI - Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents JF - NATURAL PRODUCT RESEARCH J2 - NAT PROD RES VL - 33 PY - 2019 IS - 21 SP - 3052 EP - 3056 PG - 5 SN - 1478-6419 DO - 10.1080/14786419.2018.1516658 UR - https://m2.mtmt.hu/api/publication/30409871 ID - 30409871 N1 - Funding Agency and Grant Number: [16.00353.50.04A]; [GINOP-2.3.2-15-2016-00012] Funding text: This work was supported by the Project Nr. 16.00353.50.04A within the State Program. This study was supported by the project GINOP-2.3.2-15-2016-00012 of Hungary (New ways in the natural product-based drug discovery-system metabolomic approaches to discover biologically active terpenoids of herbal and microbial origin). AB - Using sclareol and sclareolide as starting materials, the guanidine derivatives of 12-amino-11-dihomodrimane-8α-ol and 13-amino-14,15-bis-dinorlabd-8(9)-ene were synthesized by the reaction of the corresponding amines with sodium hydrogencyanamide in ethanol - water solution. Monoacyl- and diacylguanidines were prepared from activated with N,N-carbonyldiimidazole Δ8,9-bicyclohomofarnesenoic acid by the reaction with guanidine. Their structures were confirmed by the 1H and 13C NMR, IR spectral and elemental analysis data. The compounds 12, 13 and 15 were screened for their antiproliferative and cytotoxicity activities against Colo 205, Colo 320 and MRC 5 human lung fibroblasts with respect to standard drug, Cisplatin. The compounds 12 and 15 exhibits excellent results than positive control. Hence these two compounds may be act as drug lead molecules in cancer chemotherapy. LA - English DB - MTMT ER - TY - JOUR AU - Enyedy, Éva Anna AU - Mészáros, János Péter AU - Spengler, Gabriella AU - Hanif, Muhammad AU - Hartinger, Christian G. TI - Comparative solution studies and cytotoxicity of gallium(III) and iron(III) complexes of 3-hydroxy-2(1H)-pyridinones JF - POLYHEDRON J2 - POLYHEDRON VL - 172 PY - 2019 SP - 141 EP - 147 PG - 7 SN - 0277-5387 DO - 10.1016/j.poly.2019.04.010 UR - https://m2.mtmt.hu/api/publication/30637624 ID - 30637624 N1 - Department of Inorganic and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary The University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland, 1142, New Zealand Cited By :4 Export Date: 27 September 2023 CODEN: PLYHD Correspondence Address: Enyedy, É.A.; Department of Inorganic and Analytical Chemistry, Dóm tér 7, Hungary; email: enyedy@chem.u-szeged.hu Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding details: National Research, Development and Innovation Office, FK 124240, GINOP-2.3.2-15-2016-00038 Funding text 1: This work was supported by National Research, Development and Innovation Office, (Hungary) through projects GINOP-2.3.2-15-2016-00038, FK 124240 and Ministry of Human Capacities (Hungary) grant 20391-3/2018/FEKUSTRAT. Funding text 2: This work was supported by National Research, Development and Innovation Office , (Hungary) through projects GINOP-2.3.2-15-2016-00038, FK 124240 and Ministry of Human Capacities (Hungary) grant 20391-3/2018/FEKUSTRAT . LA - English DB - MTMT ER - TY - GEN AU - Enyedy, Éva Anna AU - János, P. Mészáros AU - Dömötör, Orsolya AU - Jelena, M. Poljarević AU - May, Nóra Veronika AU - G., Tamás Gál AU - István, Szatmári AU - Ferenc, Fülöp AU - Spengler, Gabriella TI - Solution equilibria of various antitumor half-sandwich organometallic complexes of 8-hydroxyquinolines and 2-picolinates: structure, stability and activity PY - 2019 UR - https://m2.mtmt.hu/api/publication/30759162 ID - 30759162 N1 - előadás LA - English DB - MTMT ER - TY - JOUR AU - Fabian, Lentz AU - Norbert, Reiling AU - Spengler, Gabriella AU - Kincses, Annamária AU - Csonka, Andrea AU - Molnár, József AU - Andreas, Hilgeroth TI - Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine JF - MOLECULES J2 - MOLECULES VL - 24 PY - 2019 IS - 16 PG - 12 SN - 1420-3049 DO - 10.3390/molecules24162873 UR - https://m2.mtmt.hu/api/publication/30760585 ID - 30760585 N1 - We acknowledge the support of the Szeged Foundation for Cancer Research and the financial support within the funding program Open Access Publishing by the German Research Foundation (DFG). Funding Agency and Grant Number: Szeged Foundation for Cancer Research; German Research Foundation (DFG) Funding text: We acknowledge the support of the Szeged Foundation for Cancer Research and the financial support within the funding program Open Access Publishing by the German Research Foundation (DFG). LA - English DB - MTMT ER - TY - CONF AU - Fási, Laura AU - Vágvölgyi, Máté AU - Latif, Ahmed Dhahir AU - Issaadi, Halima Meriem AU - Zoofishan, Zoofishan AU - Zupkó, István AU - Spengler, Gabriella AU - Martins, Ana AU - Hunyadi, Attila TI - Natural product inspired chemical approaches against MDR cancer T2 - New Diagnostic and Therapeutic Tools against Multidrug-Resistant Tumours PY - 2019 SP - 12 EP - 13 PG - 2 UR - https://m2.mtmt.hu/api/publication/31192702 ID - 31192702 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Kincses, Annamária AU - Mosolygó, Tímea AU - Małgorzata, Anna Marć AU - Nové, Márta AU - Gajdács, Márió AU - Carmen, Sanmartín AU - Helen, E McNeil AU - Jessica, MA Blair AU - Enrique, Domínguez-Álvarez TI - Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and Selenoanhydrides JF - MOLECULES J2 - MOLECULES VL - 24 PY - 2019 IS - 23 PG - 16 SN - 1420-3049 DO - 10.3390/molecules24234264 UR - https://m2.mtmt.hu/api/publication/30929822 ID - 30929822 N1 - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvos utca 6, Szeged, 6720, Hungary Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, Pamplona, 31008, Spain Instituto de Investigación Sanitaria de Navarra (IdiSNA), Irunlarrea 3, Pamplona, 31008, Spain Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, Madrid, 28006, Spain Cited By :1 Export Date: 24 June 2020 CODEN: MOLEF Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Chemicals/CAS: phthalic anhydride, 85-44-9; Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Phthalic Anhydrides; Selenium Compounds Funding details: Universidad de Navarra Funding details: University of Birmingham Funding details: Instituto de Investigación Sanitaria Fundación Jiménez Díaz, IIS-FJD Funding details: Consejo Superior de Investigaciones Científicas, CSIC Funding details: ÚNKP-18-3 Funding details: Colorado School of Mines, CSM Funding details: Fundación Caja Navarra Funding details: Ministry of Foreign Affairs and Trade, New Zealand, MFAT Funding details: Consejo Superior de Investigaciones Científicas, CSIC Funding details: European Social Fund, ESF Funding details: Tempus Közalapítvány Funding details: Biotechnology and Biological Sciences Research Council, BBSRC, BB/M02623X/1 Funding details: Consejo Superior de Investigaciones Científicas, CSIC Funding details: Magyar Tudományos Akadémia, MTA Funding details: Fundación Bancaria Caja de Ahorros de Asturias Funding details: State of New Jersey Economic Development Authority, EDA Funding details: Consejo Superior de Investigaciones Científicas, CSIC, 201780I027 Funding text 1: 1 Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, 6720 Szeged, Hungary; spengler.gabriella@med.u-szeged.hu (G.S.); kincses.annamaria@med.u-szeged.hu (A.K.); mosolygo.timea@med.u-szeged.hu (T.M.); marcmalgorzata@gmail.com (M.A.M.); nove.marta@med.u-szeged.hu (M.N.) 2 Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Eötvos utca 6, 6720 Szeged, Hungary; gajdacs.mario@pharm.u-szeged.hu 3 Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain; sanmartin@unav.es 4 Instituto de Investigación Sanitaria de Navarra (IdiSNA), Irunlarrea 3, 31008 Pamplona, Spain 5 Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK; H.E.Smith@bham.ac.uk (H.E.M.); J.M.A.Blair@bham.ac.uk (J.M.A.B.) 6 Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, 28006 Madrid, Spain Funding text 2: Funding: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ’National Excellence Program’. Gabriella Spengler was also supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. The authors of this paper received funding from the Márton Áron Research Programme financed by the Hungarian Ministry of Foreign Affairs and Trade. AK was supported by the New National Excellence Program (ÚNKP-18-3) of the Ministry of Human Capacities of Hungary and by the Campus mundi short-study program of the Tempus Public Foundation. EDA was supported by the Spanish “Consejo Superior de Investigaciones Científicas” (201780I027) (CSIC, Spanish National Research Council). CSM wishes to express gratitude to UNED-Pamplona, Fundación Bancaria “La Caixa”, and “Fundación Caja Navarra” for financial support for the project. JMAB and HEM are supported by a BBSRC David Phillips Fellowship to JMAB (BB/M02623X/1). LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Mouwakeh, Ahmad AU - Kincses, Annamária AU - Nové, Márta AU - Mosolygó, Tímea AU - Mohácsiné Farkas, Csilla AU - Kiskó, Gabriella TI - NIGELLA SATIVA ESSENTIAL OIL AS POTENTIAL SOURCE OF ANTIMICROBIAL AGENTS AGAINST STAPHYLOCOCCUS AUREUS JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - Suppl.1. PY - 2019 IS - 66. SP - 188 EP - 189 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/30734126 ID - 30734126 LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Spengler, Gabriella TI - Standard operating procedure (SOP) for disk diffusion-based quorum sensing inhibition assays JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 89 PY - 2019 IS - 4 SP - 117 EP - 125 PG - 9 SN - 0001-6659 DO - 10.33892/aph.2019.89.117-125 UR - https://m2.mtmt.hu/api/publication/31182366 ID - 31182366 LA - English DB - MTMT ER - TY - CHAP AU - Mottaghipisheh, Javad AU - Márta, Nové AU - Spengler, Gabriella AU - Kúsz, Norbert AU - Hohmann, Judit AU - Csupor, Dezső ED - Alapi, Tünde ED - Ilisz, István TI - Phytochemical and pharmacological analysis of two Iranian plants, Ducrosia anethifolia and Eremurus persicus T2 - Proceedings of the 25th International Symposium on Analytical and Environmental Problems PB - University of Szeged CY - Szeged SN - 9789633067024 PY - 2019 SP - 63 EP - 64 PG - 2 UR - https://m2.mtmt.hu/api/publication/33153883 ID - 33153883 LA - English DB - MTMT ER - TY - JOUR AU - Kashif, Bashir AU - Bashir, Ahmad AU - Abdur, Rauf AU - Amjad, Hussain AU - Gajdács, Márió AU - Molnár, József AU - Spengler, Gabriella AU - Yahia, N. Mabkhot AU - Abdul Rhman, Asayari AU - H., Algarni TI - Reversal of multi-drug resistance and Anti-proliferative activities in mouse lymphoma cells by extracts/fractions of Picea smithiana (wall) boiss JF - BIOCELL J2 - BIOCELL VL - 43 PY - 2019 IS - 1 PG - 16 SN - 0327-9545 UR - https://m2.mtmt.hu/api/publication/30709696 ID - 30709696 N1 - Nincs jelölve levelező szerzőség a közleményen (BA, SZTE admin5, 2024-04-08) LA - English DB - MTMT ER - TY - GEN AU - Kincses, Annamária AU - Szabó, Stefánia AU - Mosolygó, Tímea AU - Saijo, Ryosuke AU - Kawase, Masami AU - Spengler, Gabriella TI - Metal complexes as novel antibacterial agents against Staphylococcus aureus CY - (poszter) PY - 2019 UR - https://m2.mtmt.hu/api/publication/30706107 ID - 30706107 N1 - poszter LA - English DB - MTMT ER - TY - CHAP AU - Kincses, Annamária AU - Spengler, Gabriella ED - Tóth, Bianka TI - Szelénvegyületek efflux pumpa és biofilm gátló hatásának vizsgálata Salmonella Typhimurium törzseken T2 - Tudományos eredmények a nagyvilágból - bővített kiadás PB - Tempus Közalapítvány CY - Budapest SN - 9786155319648 PY - 2019 SP - 74 EP - 79 PG - 6 UR - https://m2.mtmt.hu/api/publication/30717898 ID - 30717898 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Spengler, Gabriella TI - The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 8 PY - 2019 IS - 4 PG - 18 SN - 2079-6382 DO - 10.3390/antibiotics8040270 UR - https://m2.mtmt.hu/api/publication/31011847 ID - 31011847 N1 - Cited By :3 Export Date: 24 June 2020 Correspondence Address: Gajdács, M.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Hungary; email: gajdacs.mario@pharm.u-szeged.hu Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; atorvastatin, 134523-00-5, 134523-03-8; bleomycin, 11056-06-7, 9041-93-4; celecoxib, 169590-42-5; chlorpromazine, 50-53-3, 69-09-0; chlorzoxazone, 95-25-0; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; clotrimazole, 23593-75-1; coumarin, 91-64-5; dipyrone, 50567-35-6, 5907-38-0, 68-89-3; floxuridine, 50-91-9; fluconazole, 86386-73-4; fluorouracil, 51-21-8; ivermectin, 70288-86-7; mebendazole, 31431-39-7; metformin, 1115-70-4, 657-24-9; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; miltefosine, 58066-85-6; niclosamide, 50-65-7; promethazine, 58-33-3, 60-87-7; simvastatin, 79902-63-9; streptozocin, 18883-66-4; thioridazine, 130-61-0, 50-52-2; toremifene, 89778-26-7; verapamil, 152-11-4, 52-53-9 Manufacturers: Ebewe, Austria; Labaz, France; Glaxo SmithKline, Hungary; Pfizer, Hungary; Richter, Hungary; Sigma Aldrich, Hungary; Teva, Israel; Baxter, United States Funding details: European Social Fund, ESF Funding details: European Commission, EC Funding details: NTP-NTFÖ-18-C-0225 Funding text 1: Acknowledgments: The authors would like to thank Anikó Váradi Vigyikán for texcellent laboratory assistance. The authors express their gratitude to Erno˝ Szegedi for providing the QS-signal indicator and single-producing strains for our study. This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. M.G. was supported by the National Youth Excellence Scholarship [Grant Number NTP-NTFÖ-18-C-0225] and the ESCMID Mentorship and Observership Programme. Part of this study was presented at the 18th International Congress of the Hungarian Society for Microbiology (MMT; Budapest, Hungary). Funding Agency and Grant Number: European UnionEuropean Union (EU); European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.4. A/2-11-1-2012-0001]; National Youth Excellence Scholarship [NTP-NTFO-18-C-0225]; ESCMID Mentorship and Observership Programme Funding text: The authors would like to thank Aniko Varadi Vigyikan for texcellent laboratory assistance. The authors express their gratitude to Erno Szegedi for providing the QS-signal indicator and single-producing strains for our study. This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TAMOP 4.2.4. A/2-11-1-2012-0001 'National Excellence Program'. M.G. was supported by the National Youth Excellence Scholarship [Grant Number NTP-NTFO-18-C-0225] and the ESCMID Mentorship and Observership Programme. Part of this study was presented at the 18th International Congress of the Hungarian Society for Microbiology (MMT; Budapest, Hungary). Cited By :4 Export Date: 31 July 2020 Correspondence Address: Gajdács, M.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Hungary; email: gajdacs.mario@pharm.u-szeged.hu Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; atorvastatin, 134523-00-5, 134523-03-8; bleomycin, 11056-06-7, 9041-93-4; celecoxib, 169590-42-5; chlorpromazine, 50-53-3, 69-09-0; chlorzoxazone, 95-25-0; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; clotrimazole, 23593-75-1; coumarin, 91-64-5; dipyrone, 50567-35-6, 5907-38-0, 68-89-3; floxuridine, 50-91-9; fluconazole, 86386-73-4; fluorouracil, 51-21-8; ivermectin, 70288-86-7; mebendazole, 31431-39-7; metformin, 1115-70-4, 657-24-9; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; miltefosine, 58066-85-6; niclosamide, 50-65-7; promethazine, 58-33-3, 60-87-7; simvastatin, 79902-63-9; streptozocin, 18883-66-4; thioridazine, 130-61-0, 50-52-2; toremifene, 89778-26-7; verapamil, 152-11-4, 52-53-9 Manufacturers: Ebewe, Austria; Labaz, France; Glaxo SmithKline, Hungary; Pfizer, Hungary; Richter, Hungary; Sigma Aldrich, Hungary; Teva, Israel; Baxter, United States Funding details: European Social Fund, ESF Funding details: European Commission, EC Funding details: NTP-NTFÖ-18-C-0225 Funding text 1: Acknowledgments: The authors would like to thank Anikó Váradi Vigyikán for texcellent laboratory assistance. The authors express their gratitude to Erno˝ Szegedi for providing the QS-signal indicator and single-producing strains for our study. This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. M.G. was supported by the National Youth Excellence Scholarship [Grant Number NTP-NTFÖ-18-C-0225] and the ESCMID Mentorship and Observership Programme. Part of this study was presented at the 18th International Congress of the Hungarian Society for Microbiology (MMT; Budapest, Hungary). Cited By :10 Export Date: 18 January 2021 Correspondence Address: Gajdács, M.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Hungary; email: gajdacs.mario@pharm.u-szeged.hu Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; atorvastatin, 134523-00-5, 134523-03-8; bleomycin, 11056-06-7, 9041-93-4; celecoxib, 169590-42-5; chlorpromazine, 50-53-3, 69-09-0; chlorzoxazone, 95-25-0; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; clotrimazole, 23593-75-1; coumarin, 91-64-5; dipyrone, 50567-35-6, 5907-38-0, 68-89-3; floxuridine, 50-91-9; fluconazole, 86386-73-4; fluorouracil, 51-21-8; ivermectin, 70288-86-7; mebendazole, 31431-39-7; metformin, 1115-70-4, 657-24-9; methotrexate, 15475-56-6, 59-05-2, 7413-34-5; miltefosine, 58066-85-6; niclosamide, 50-65-7; promethazine, 58-33-3, 60-87-7; simvastatin, 79902-63-9; streptozocin, 18883-66-4; thioridazine, 130-61-0, 50-52-2; toremifene, 89778-26-7; verapamil, 152-11-4, 52-53-9 Manufacturers: Ebewe, Austria; Labaz, France; Glaxo SmithKline, Hungary; Pfizer, Hungary; Richter, Hungary; Sigma Aldrich, Hungary; Teva, Israel; Baxter, United States Funding details: European Social Fund, ESF Funding details: European Commission, EC Funding details: NTP-NTFÖ-18-C-0225 Funding text 1: Acknowledgments: The authors would like to thank Anikó Váradi Vigyikán for texcellent laboratory assistance. The authors express their gratitude to Erno˝ Szegedi for providing the QS-signal indicator and single-producing strains for our study. This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. M.G. was supported by the National Youth Excellence Scholarship [Grant Number NTP-NTFÖ-18-C-0225] and the ESCMID Mentorship and Observership Programme. Part of this study was presented at the 18th International Congress of the Hungarian Society for Microbiology (MMT; Budapest, Hungary). LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Molnár, József AU - Spengler, Gabriella TI - Establishing standard operating procedures (SOP) for disk diffusion quorum sensing inhibition assay JF - Journal of Infectious Diseases and Treatment J2 - J Infec Dis Treat VL - 5 PY - 2019 IS - 1 SP - 40 EP - 40 PG - 1 SN - 2472-1093 UR - https://m2.mtmt.hu/api/publication/30865339 ID - 30865339 LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - József, Magyari AU - Kincses, Annamária AU - Nové, Márta AU - Mosolygó, Tímea AU - Berta, Barta Holló AU - Katalin, Mészáros Szécsényi AU - Spengler, Gabriella TI - Metal-Based Antimicrobial Strategies: An In Vitro Study on the Efficacy of Hydrazone-Based Transition Metal Complexes JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 66 PY - 2019 IS - Suppl.1 SP - 134 EP - 135 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/30731348 ID - 30731348 LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Szegedi, Ernő AU - Molnár, József AU - Spengler, Gabriella TI - Pharmaceutical Compounds as Quorum Sensing (Qs) Inhibitors JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 66 PY - 2019 IS - Suppl.1 SP - 30 EP - 31 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/30731239 ID - 30731239 LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Dorota, Lazevska AU - Katarzyna, Kiec-Kononowicz AU - Carmen, Sanmartín AU - Jadwiga, Handzlik AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella TI - Quorum Sensing Inhibition by Sulfur and Selenium-Containing Organochalcogens: A Comparative In Vitro Study JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 66 PY - 2019 IS - Suppl.1 SP - 29 EP - 30 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/30731232 ID - 30731232 LA - English DB - MTMT ER - TY - JOUR AU - Nové, Márta AU - Kincses, Annamária AU - Mosolygó, Tímea AU - Ayman, El-Farouki AU - József, Magyari AU - Berta, Holló Barta AU - Burián, Katalin AU - Katalin, Szécsényi Mészáros AU - Spengler, Gabriella TI - Antibacterial effect of diazine-ring containing hydrazones and their metal complexes JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 66 PY - 2019 IS - Suppl. 1 SP - 75 EP - 76 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/30734081 ID - 30734081 LA - English DB - MTMT ER - TY - JOUR AU - Mészáros, János Péter AU - Poljarevic, Jelena M. AU - Gál, Gyula Tamás AU - May, Nóra Veronika AU - Spengler, Gabriella AU - Enyedy, Éva Anna TI - Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone JF - JOURNAL OF INORGANIC BIOCHEMISTRY J2 - J INORG BIOCHEM VL - 195 PY - 2019 SP - 91 EP - 100 PG - 10 SN - 0162-0134 DO - 10.1016/j.jinorgbio.2019.02.015 UR - https://m2.mtmt.hu/api/publication/30483477 ID - 30483477 N1 - This work was supported by National Research, Development and Innovation Office-NKFIA through projects GINOP-2.3.2-15-2016-00038, FK 124240, K 115762, Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT and the J. Bolyai Research Scholarship of the Hungarian Academy of Sciences (É.A.E, N.V.M.). The authors thank Ms. Fanni Veréb for performing some titrations Funding Agency and Grant Number: National Research Development and Innovation Office-NKFIA [GINOP-2.3.2-15-2016-00038, FK 124240, K 115762]; Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]; J. Bolyai Research Scholarship of the Hungarian Academy of Sciences Funding text: This work was supported by National Research Development and Innovation Office-NKFIA through projects GINOP-2.3.2-15-2016-00038, FK 124240, K 115762, Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT and the J. Bolyai Research Scholarship of the Hungarian Academy of Sciences (E.A.E, N.V.M.). The authors thank Ms. Fanni Vereb for performing some titrations. AB - Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η 5 -C 5 Me 5 )(H 2 O) 3 ] 2+ . Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η 6 ‑p‑cymene), Ru(η 6 ‑toluene) complexes were also studied. 1 H NMR, UV–visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η 6 ‑p‑cymene) > Ru(η 6 ‑toluene) > Rh(η 5 -C 5 Me 5 ). Despite this order, the highest extent of complex formation is seen for the Rh(η 5 -C 5 Me 5 ) complexes at pH 7.4. Formation constant of [Rh(η 5 -C 5 Me 5 )(H 2 curcumin)(H 2 O)] + reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic cations. © 2019 LA - English DB - MTMT ER - TY - JOUR AU - Mónico, Andreia AU - Ramalhete, Cátia AU - André, Vânia AU - Spengler, Gabriella AU - Mulhovo, Silva AU - Duarte, M. Teresa AU - Ferreira, Maria-José U. TI - Cucurbalsaminones A–C, Rearranged Triterpenoids with a 5/6/3/6/5-Fused Pentacyclic Carbon Skeleton from Momordica balsamina , as Multidrug Resistance Reversers JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 82 PY - 2019 IS - 8 SP - 2138 EP - 2143 PG - 6 SN - 0163-3864 DO - 10.1021/acs.jnatprod.9b00019 UR - https://m2.mtmt.hu/api/publication/30777928 ID - 30777928 N1 - Funding Agency and Grant Number: European Structural & Investment Funds through the COMPETE Programme; FCT, Fundacao para a Ciencia e a Tecnologia [PTDC/MED-QUI/30591/2017, SAICTPAC/0019/2015] Funding text: This study was financially supported by European Structural & Investment Funds through the COMPETE Programme and from National Funds through FCT, Fundacao para a Ciencia e a Tecnologia, projects PTDC/MED-QUI/30591/2017 and SAICTPAC/0019/2015. We also acknowledge Prof. Carlos Cordeiro, Faculty of Sciences, University of Lisbon, for the high-resolution mass spectrometric data (FCT, REDE/1501/REM/2005). LA - English DB - MTMT ER - TY - GEN AU - Mosolygó, Tímea AU - Kincses, Annamária AU - Nové, Márta AU - El-Farouki, Ayman AU - Magyari, József AU - Barta, Holló Berta AU - Mészáros, Szécsényi Katalin AU - Spengler, Gabriella TI - Antibacterial effect of diazine-ring containing hydrazones and their metal complexes CY - (poszter) PY - 2019 UR - https://m2.mtmt.hu/api/publication/30706104 ID - 30706104 N1 - poszter LA - English DB - MTMT ER - TY - GEN AU - Mosolygó, Tímea AU - Borbély, Bence AU - Szatmári, Marion AU - Varga, Borisz AU - Kincses, Annamária AU - Spengler, Gabriella TI - Antimicrobial effect of phenothiazines alone, and in combination with antibiotics in cases of Chlamydia infection CY - (poszter) PY - 2019 UR - https://m2.mtmt.hu/api/publication/30706100 ID - 30706100 N1 - poszter LA - English DB - MTMT ER - TY - JOUR AU - Mosolygó, Tímea AU - Mouwakeh, Ahmad AU - Hussein Ali, Munira AU - Kincses, Annamária AU - Mohácsiné Farkas, Csilla AU - Kiskó, Gabriella AU - Spengler, Gabriella TI - Bioactive Compounds of Nigella sativa Essential Oil as Antibacterial Agents against Chlamydia trachomatis D JF - MICROORGANISMS J2 - MICROORGANISMS VL - 7 PY - 2019 IS - 9 PG - 8 SN - 2076-2607 DO - 10.3390/microorganisms7090370 UR - https://m2.mtmt.hu/api/publication/30811942 ID - 30811942 N1 - This study was supported by the GINOP-2.3.2-15-2016-00012 project (University of Szeged, Hungary). G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.K. was supported by the ÚNKP-18-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. A.M., C.M.F and G.K. were supported by the European Union and co-financed by the European Social Fund (grant agreement no. EFOP-3.6.3-VEKOP-16-2017-00005). Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, 6720, Hungary Department of Microbiology and Biotechnology, Faculty of Food Science, Szent István University, Budapest, 1118, Hungary Export Date: 3 December 2019 Correspondence Address: Mosolygó, T.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of SzegedHungary; email: mosolygo.timea@med.u-szeged.hu Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, 6720, Hungary Department of Microbiology and Biotechnology, Faculty of Food Science, Szent István University, Budapest, 1118, Hungary Export Date: 24 June 2020 Correspondence Address: Mosolygó, T.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of SzegedHungary; email: mosolygo.timea@med.u-szeged.hu Funding details: European Social Fund, ESF Funding details: European Commission, EU Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: Funding: This study was supported by the GINOP-2.3.2-15-2016-00012 project (University of Szeged, Hungary). G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.K. was supported by the ÚNKP-18-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. A.M., C.M.F and G.K. were supported by the European Union and co-financed by the European Social Fund (grant agreement no. EFOP-3.6.3-VEKOP-16-2017-00005). Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, 6720, Hungary Department of Microbiology and Biotechnology, Faculty of Food Science, Szent István University, Budapest, 1118, Hungary Export Date: 31 July 2020 Correspondence Address: Mosolygó, T.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of SzegedHungary; email: mosolygo.timea@med.u-szeged.hu Funding details: European Social Fund, ESF Funding details: European Commission, EU Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: Funding: This study was supported by the GINOP-2.3.2-15-2016-00012 project (University of Szeged, Hungary). G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.K. was supported by the ÚNKP-18-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. A.M., C.M.F and G.K. were supported by the European Union and co-financed by the European Social Fund (grant agreement no. EFOP-3.6.3-VEKOP-16-2017-00005). Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, 6720, Hungary Department of Microbiology and Biotechnology, Faculty of Food Science, Szent István University, Budapest, 1118, Hungary Export Date: 18 January 2021 Correspondence Address: Mosolygó, T.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of SzegedHungary; email: mosolygo.timea@med.u-szeged.hu Funding details: Szegedi Tudományegyetem, SZTE Funding details: European Social Fund, ESF, EFOP-3.6.3-VEKOP-16-2017-00005 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Commission, EC Funding text 1: Funding: This study was supported by the GINOP-2.3.2-15-2016-00012 project (University of Szeged, Hungary). G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.K. was supported by the ÚNKP-18-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. A.M., C.M.F and G.K. were supported by the European Union and co-financed by the European Social Fund (grant agreement no. EFOP-3.6.3-VEKOP-16-2017-00005). LA - English DB - MTMT ER - TY - JOUR AU - Mosolygó, Tímea AU - Kincses, Annamária AU - Csonka, Andrea AU - Tönki, Ádám Szabó AU - Witek, Karolina AU - Sanmartín, Carmen AU - Marć, Małgorzata Anna AU - Handzlik, Jadwiga AU - Kieć-Kononowicz, Katarzyna AU - Domínguez-Álvarez, Enrique AU - Spengler, Gabriella TI - Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors JF - MOLECULES J2 - MOLECULES VL - 24 PY - 2019 IS - 8 SN - 1420-3049 DO - 10.3390/molecules24081487 UR - https://m2.mtmt.hu/api/publication/30645681 ID - 30645681 N1 - G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences, by the GINOP-2.3.2-15-2016-00038 project and by the University of Szeged, through the project SZTE ÁOK-KKA 2018/270-62-2. A.K. was supported by the ÚNKP-17-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. E.D.A. was supported by the Spanish “Consejo Superior de Investigaciones Científicas” (CSIC, Spanish National Research Council), through Project 201780I027. Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Department of Obstetrics and Gynecology, Faculty of Medicine, University of Szeged, Semmelweis utca 1, Szeged, 6725, Hungary Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, Pamplona, 31008, Spain Instituto de Investigación Sanitaria de Navarra (IdiSNA), Irunlarrea 3, Pamplona, 31008, Spain Interdisciplinary Excellence Centre, Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, 6720, Hungary Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, Madrid, 28006, Spain Export Date: 22 August 2019 CODEN: MOLEF Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Funding details: Universidad de Navarra Funding details: Consejo Superior de Investigaciones Científicas Funding details: Instituto de Investigación Sanitaria Fundación Jiménez Díaz Funding details: Consejo Superior de Investigaciones Científicas Funding details: SZTE ÁOK-KKA 2018/270-62-2 Funding details: Consejo Superior de Investigaciones Científicas, 201780I027 Funding details: Magyar Tudományos Akadémia, GINOP-2.3.2-15-2016-00038 Funding details: Consejo Superior de Investigaciones Científicas Funding text 1: Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, 6720 Szeged, Hungary; mosolygo.timea@med.u-szeged.hu (T.M.); kincses.annamaria@med.u-szeged.hu (A.K.); csonka.andrea83@gmail.com (A.C.); szabotadam@gmail.com (Á.S.T.) Department of Obstetrics and Gynecology, Faculty of Medicine, University of Szeged, Semmelweis utca 1, 6725 Szeged, Hungary Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland; karolina.witek@uj.edu.pl (K.W.); marcmalgorzata@gmail.com (M.A.M.); j.handzlik@uj.edu.pl (J.H.); mfkonono@cyf-kr.edu.pl (K.K.-K.) Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain; sanmartin@unav.es Instituto de Investigación Sanitaria de Navarra (IdiSNA), Irunlarrea 3, 31008 Pamplona, Spain Interdisciplinary Excellence Centre, Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, 6720 Szeged, Hungary Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, 28006 Madrid, Spain Correspondence: e.dominguez-alvarez@iqog.csic.es (E.D-Á.); spengler.gabriella@med.u-szeged.hu (G.S.); Tel.: +34-91-258-7661 (E.D.-Á.); +36-62-445-115 (G.S.) These authors contributed equally to this work. Funding text 2: Funding: G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences, by the GINOP-2.3.2-15-2016-00038 project and by the University of Szeged, through the project SZTE ÁOK-KKA 2018/270-62-2. A.K. was supported by the ÚNKP-17-3 New National Excellence Program of the Ministry of Human Capacities of Hungary. E.D.A. was supported by the Spanish “Consejo Superior de Investigaciones Científicas” (CSIC, Spanish National Research Council), through Project 201780I027. Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Department of Obstetrics and Gynecology, Faculty of Medicine, University of Szeged, Semmelweis utca 1, Szeged, 6725, Hungary Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, Pamplona, 31008, Spain Instituto de Investigación Sanitaria de Navarra (IdiSNA), Irunlarrea 3, Pamplona, 31008, Spain Interdisciplinary Excellence Centre, Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, 6720, Hungary Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, Madrid, 28006, Spain Export Date: 3 December 2019 CODEN: MOLEF Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General (IQOG-CSIC), Consejo Superior de Investigaciones Científicas, Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es LA - English DB - MTMT ER - TY - CONF AU - Ahmad, MOUWAKEH AU - Telbisz, Á. AU - Spengler, Gabriella AU - Mohácsiné Farkas, Csilla AU - Kiskó, Gabriella TI - Antibiotic resistance inhibitors of Nigella sativa essential oil against Listeria monocytogenes T2 - The Science of Food Safety – What’s our Future? FSAI SCIENCE CONFERENCE 2019 PY - 2019 UR - https://m2.mtmt.hu/api/publication/30811833 ID - 30811833 LA - English DB - MTMT ER - TY - JOUR AU - Mouwakeh, Ahmad AU - Kincses, Annamária AU - Nové, Márta AU - Mosolygó, Tímea AU - Mohácsiné Farkas, Csilla AU - Kiskó, Gabriella AU - Spengler, Gabriella TI - Nigella sativa essential oil and its bioactive compounds as resistance modifiers against Staphylococcus aureus JF - PHYTOTHERAPY RESEARCH J2 - PHYTOTHER RES VL - 33 PY - 2019 IS - 4 SP - 1010 EP - 1018 PG - 9 SN - 0951-418X DO - 10.1002/ptr.6294 UR - https://m2.mtmt.hu/api/publication/30409867 ID - 30409867 N1 - Department of Microbiology and Biotechnology, Szent István University, Budapest, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary Cited By :5 Export Date: 31 July 2020 CODEN: PHYRE Correspondence Address: Kiskó, G.; Department of Microbiology and Biotechnology, Szent István UniversityHungary; email: kisko.gabriella@etk.szie.hu Chemicals/CAS: carvacrol, 499-75-2; ciprofloxacin, 85721-33-1; crystal violet, 467-63-0, 548-62-9; ethidium bromide, 1239-45-8; para cymene, 99-87-6; tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; thymoquinone, 490-91-5; 4-cymene; Anti-Bacterial Agents; Anti-Infective Agents; Benzoquinones; carvacrol; Monoterpenes; Oils, Volatile; Plant Extracts; thymoquinone Manufacturers: Sigma Aldrich, Germany; MP Biomedicals, France Funding details: GINOP‐2.3.2‐15‐2016‐ 00012 Funding details: European Social Fund, ESF, EFOP‐3.6.3‐VEKOP‐16‐2017‐00005 EFOP‐ 3.6.3‐VEKOP‐16‐2017‐00009 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Commission, EC Funding details: European Social Fund, ESF, EFOP‐3.6.3‐VEKOP‐16‐2017‐ 00005, EFOP‐3.6.3‐VEKOP‐16‐2017‐00009 Funding details: European Commission, EC Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: European Union and co‐financed by the European Social Fund, Grant/Award Number: EFOP‐3.6.3‐VEKOP‐16‐2017‐00005 EFOP‐ 3.6.3‐VEKOP‐16‐2017‐00009; János Bolyai Research Scholarship of the Hungarian Academy of Sciences; University of Szeged, Grant/ Award Number: GINOP‐2.3.2‐15‐2016‐ 00012; European Union and the State of Hungary and co‐financed by the European Social Fund, Grant/Award Number: TÁMOP 4.2.4. A/2‐11‐1‐2012‐0001; ÚNKP‐18‐3 New National Excellence Program of the Ministry of Human Capacities of Hungary Funding text 2: The study was supported by the European Union and co‐financed by the European Social Fund (grants EFOP‐3.6.3‐VEKOP‐16‐2017‐ 00005 and EFOP‐3.6.3‐VEKOP‐16‐2017‐00009). This research was supported by the European Union and the State of Hungary and co‐ financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2‐11‐1‐2012‐0001 “National Excellence Program.” This study was supported by the GINOP‐2.3.2‐15‐2016‐00012 project (University of Szeged, Hungary). Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses was supported by the ÚNKP‐18‐3 New National Excellence Program of the Ministry of Human Capacities of Hungary. Authors express special thanks to Professor Éva Szőke, Department of Pharmacognosy, Semmelweis University, Budapest, for preparation of the essential oil used in the experiments. Department of Microbiology and Biotechnology, Szent István University, Budapest, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary Cited By :9 Export Date: 18 January 2021 CODEN: PHYRE Correspondence Address: Kiskó, G.; Department of Microbiology and Biotechnology, Szent István UniversityHungary; email: kisko.gabriella@etk.szie.hu Chemicals/CAS: carvacrol, 499-75-2; ciprofloxacin, 85721-33-1; crystal violet, 467-63-0, 548-62-9; ethidium bromide, 1239-45-8; para cymene, 99-87-6; tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; thymoquinone, 490-91-5; 4-cymene; Anti-Bacterial Agents; Anti-Infective Agents; Benzoquinones; carvacrol; Monoterpenes; Oils, Volatile; Plant Extracts; thymoquinone Manufacturers: Sigma Aldrich, Germany; MP Biomedicals, France Funding details: Szegedi Tudományegyetem, SZTE, GINOP‐2.3.2‐15‐2016‐ 00012 Funding details: European Social Fund, ESF, EFOP‐3.6.3‐VEKOP‐16‐2017‐00005 EFOP‐ 3.6.3‐VEKOP‐16‐2017‐00009 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Commission, EC Funding details: Szegedi Tudományegyetem, SZTE Funding details: European Social Fund, ESF, A/2‐11‐1‐2012‐0001, EFOP‐3.6.3‐VEKOP‐16‐2017‐ 00005, EFOP‐3.6.3‐VEKOP‐16‐2017‐00009 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Commission, EC Funding text 1: European Union and co‐financed by the European Social Fund, Grant/Award Number: EFOP‐3.6.3‐VEKOP‐16‐2017‐00005 EFOP‐ 3.6.3‐VEKOP‐16‐2017‐00009; János Bolyai Research Scholarship of the Hungarian Academy of Sciences; University of Szeged, Grant/ Award Number: GINOP‐2.3.2‐15‐2016‐ 00012; European Union and the State of Hungary and co‐financed by the European Social Fund, Grant/Award Number: TÁMOP 4.2.4. A/2‐11‐1‐2012‐0001; ÚNKP‐18‐3 New National Excellence Program of the Ministry of Human Capacities of Hungary Funding text 2: The study was supported by the European Union and co‐financed by the European Social Fund (grants EFOP‐3.6.3‐VEKOP‐16‐2017‐ 00005 and EFOP‐3.6.3‐VEKOP‐16‐2017‐00009). This research was supported by the European Union and the State of Hungary and co‐ financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2‐11‐1‐2012‐0001 “National Excellence Program.” This study was supported by the GINOP‐2.3.2‐15‐2016‐00012 project (University of Szeged, Hungary). Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses was supported by the ÚNKP‐18‐3 New National Excellence Program of the Ministry of Human Capacities of Hungary. Authors express special thanks to Professor Éva Szőke, Department of Pharmacognosy, Semmelweis University, Budapest, for preparation of the essential oil used in the experiments. AB - Nigella sativa essential oil (EO) and its compounds (thymoquinone, carvacrol, and p-cymene) have a broad antimicrobial spectrum. The aim of this study was to investigate the antimicrobial and resistance modifying activity of N. sativa EO, thymoquinone, carvacrol, and p-cymene against one methicillin susceptible and one methicillin resistant Staphylococcus aureus strain. N. sativa EO, thymoquinone, carvacrol, and p-cymene were assessed for antimicrobial activity and modulation of antimicrobial resistance (by broth microdilution), inhibition of antimicrobial efflux (by ethidium bromide [EtBr] accumulation assay), relative expression of mepA gene (by real-time reverse transcriptase quantitative polymerase chain reaction), membrane disrupting effect (by LIVE/DEAD BacLight™ Kit), and finally antibiofilm activity (by the crystal violet assay). Both strains of S. aureus were susceptible to N. sativa EO, thymoquinone, and carvacrol. N. sativa EO and carvacrol induced the increase of EtBr accumulated by both S. aureus strains. Membrane integrity of ATCC strain was disrupted by carvacrol and p-cymene, whereas for the methicillin resistant S. aureus (MRSA) strain the membrane integrity was disrupted by each compound. N. sativa EO and its bioactive compounds such as carvacrol and p-cymene could be applied as resistance modifiers in MRSA strains. LA - English DB - MTMT ER - TY - JOUR AU - Nasim, Muhammad Jawad AU - Witek, Karolina AU - Kincses, Annamária AU - Abdin, Ahmad Yaman AU - Żesławska, Ewa AU - Marć, Małgorzata Anna AU - Gajdács, Márió AU - Spengler, Gabriella AU - Nitek, Wojciech AU - Latacz, Gniewomir AU - Karczewska, Elżbieta AU - Kieć-Kononowicz, Katarzyna AU - Handzlik, Jadwiga AU - Jacob, Claus TI - Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria JF - NEW JOURNAL OF CHEMISTRY J2 - NEW J CHEM VL - 43 PY - 2019 IS - 15 SP - 6021 EP - 6031 PG - 11 SN - 1144-0546 DO - 10.1039/c9nj00563c UR - https://m2.mtmt.hu/api/publication/30626034 ID - 30626034 N1 - Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus B2.1, Saarbruecken, Saarland D-66123, Germany Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, Cracow, 30-688, Poland Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, Cracow, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Department of Chemistry, Institute of Biology, Pedagogical University, Podchorążych 2, Kraków, 30-084, Poland Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków, 30-387, Poland Cited By :1 Export Date: 22 August 2019 CODEN: NJCHE Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, Poland; email: jadhandz@interia.pl Chemicals/CAS: benzyl selenocyanate, 4671-93-6; fluconazole, 86386-73-4; itraconazole, 84625-61-6; norfloxacin, 70458-96-7; oxacillin, 1173-88-2, 66-79-5, 7240-38-2; piperacillin, 59703-84-3, 61477-96-1 Funding details: 4-09-21, K/ZDS/007886 Funding text 1: The authors acknowledge the financial support provided by the Jagiellonian University, Krakow, Poland (project K/ZDS/007886), University of Saarland, Saarbruecken, Germany and INTERREG-VAGR program (BIOVAL, Grant No. 4-09-21). We also acknowledge the support from the Erasmus+ mobility programme 2016–2017. Special thanks go to many other colleagues from the Academiacs International network (www.academiacs.eu) and ‘‘Pharmasophy’’ for their helpful discussions and advice. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses and Márió Gajdács were supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. Funding Agency and Grant Number: Jagiellonian University, Krakow, Poland [K/ZDS/007886]; University of Saarland, Saarbruecken, Germany; INTERREG-VAGR program (BIOVAL) [4-09-21]; Erasmus+ mobility programme 2016-2017; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; New National Excellence Program of the Ministry of Human Capacities [UNKP-17-3] Funding text: The authors acknowledge the financial support provided by the Jagiellonian University, Krakow, Poland (project K/ZDS/007886), University of Saarland, Saarbruecken, Germany and INTERREG-VAGR program (BIOVAL, Grant No. 4-09-21). We also acknowledge the support from the Erasmus+ mobility programme 2016-2017. Special thanks go to many other colleagues from the Academiacs International network (www.academiacs.eu) and "Pharmasophy'' for their helpful discussions and advice. Gabriella Spengler was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamaria Kincses and Mario Gajdacs were supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus B2.1, Saarbruecken, Saarland D-66123, Germany Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, Cracow, 30-688, Poland Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, Cracow, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Department of Chemistry, Institute of Biology, Pedagogical University, Podchorążych 2, Kraków, 30-084, Poland Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków, 30-387, Poland Cited By :5 Export Date: 31 July 2020 CODEN: NJCHE Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, Poland; email: jadhandz@interia.pl Chemicals/CAS: benzyl selenocyanate, 4671-93-6; fluconazole, 86386-73-4; itraconazole, 84625-61-6; norfloxacin, 70458-96-7; oxacillin, 1173-88-2, 66-79-5, 7240-38-2; piperacillin, 59703-84-3, 61477-96-1 Funding details: K/ZDS/007886 Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: Erasmus+ Funding details: Magyar Tudományos Akadémia, MTA Funding details: 4-09-21 Funding text 1: The authors acknowledge the financial support provided by the Jagiellonian University, Krakow, Poland (project K/ZDS/007886), University of Saarland, Saarbruecken, Germany and INTERREG-VAGR program (BIOVAL, Grant No. 4-09-21). We also acknowledge the support from the Erasmus+ mobility programme 2016–2017. Special thanks go to many other colleagues from the Academiacs International network (www.academiacs.eu) and ‘‘Pharmasophy’’ for their helpful discussions and advice. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses and Márió Gajdács were supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, Campus B2.1, Saarbruecken, Saarland D-66123, Germany Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, Cracow, 30-688, Poland Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, Cracow, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Department of Chemistry, Institute of Biology, Pedagogical University, Podchorążych 2, Kraków, 30-084, Poland Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków, 30-387, Poland Cited By :8 Export Date: 18 January 2021 CODEN: NJCHE Correspondence Address: Handzlik, J.; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, Medyczna 9, Poland; email: jadhandz@interia.pl Chemicals/CAS: benzyl selenocyanate, 4671-93-6; fluconazole, 86386-73-4; itraconazole, 84625-61-6; norfloxacin, 70458-96-7; oxacillin, 1173-88-2, 66-79-5, 7240-38-2; piperacillin, 59703-84-3, 61477-96-1 Funding details: K/ZDS/007886 Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: Erasmus+ Funding details: Magyar Tudományos Akadémia, MTA Funding details: 4-09-21 Funding text 1: The authors acknowledge the financial support provided by the Jagiellonian University, Krakow, Poland (project K/ZDS/007886), University of Saarland, Saarbruecken, Germany and INTERREG-VAGR program (BIOVAL, Grant No. 4-09-21). We also acknowledge the support from the Erasmus+ mobility programme 2016–2017. Special thanks go to many other colleagues from the Academiacs International network (www.academiacs.eu) and ‘‘Pharmasophy’’ for their helpful discussions and advice. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses and Márió Gajdács were supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. LA - English DB - MTMT ER - TY - JOUR AU - Neto, Sara AU - Duarte, Noélia AU - Pedro, Cecília AU - Spengler, Gabriella AU - Molnár, József AU - Ferreira, Maria‐José U. TI - Effective MDR reversers through phytochemical study of Euphorbia boetica JF - PHYTOCHEMICAL ANALYSIS J2 - PHYTOCHEM ANALYSIS VL - 30 PY - 2019 IS - 5 SP - 498 EP - 511 PG - 14 SN - 0958-0344 DO - 10.1002/pca.2841 UR - https://m2.mtmt.hu/api/publication/30777937 ID - 30777937 N1 - Funding Agency and Grant Number: Fundacao para a Ciencia e a Tecnologia [PTDC/MED-QUI/30591/2017, SAICTPAC/0019/2015, LISBOA-01-0145-FEDER-402-022125] LA - English DB - MTMT ER - TY - JOUR AU - Ntungwe, E AU - Isca, V AU - Vágvölgyi, Máté AU - Spengler, Gabriella AU - Hunyadi, Attila AU - Rijo, P TI - Bio-guided phytochemical study of Plectranthus mutabilis Codd. JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 18 PY - 2019 IS - 85 SP - 1474 EP - 1474 PG - 1 SN - 0032-0943 DO - 10.1055/s-0039-3399860 UR - https://m2.mtmt.hu/api/publication/31192713 ID - 31192713 LA - English DB - MTMT ER - TY - CONF AU - Orsolya, Dömötör AU - G., Tamás Gál AU - Nóra, V. May AU - Spengler, Gabriella AU - Kiss, Márton Attila AU - Nagyné Frank, Éva AU - Éva, A. Enyedy TI - Studies on copper(II) and organoruthenium(II) complexes of pyrazolo-thiosemicarbazones: anticancer activity, structure and stability T2 - ISMEC 2019 International Symposium on Metal Complexes BOOK OF ABSTRACTS PY - 2019 SP - 101 UR - https://m2.mtmt.hu/api/publication/32893996 ID - 32893996 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella TI - A rák elleni modern immunterápia JF - MAGYAR KÉMIKUSOK LAPJA J2 - MAGY KEM LAP VL - 74 PY - 2019 IS - 2 SP - 42 EP - 43 PG - 2 SN - 0025-0163 UR - https://m2.mtmt.hu/api/publication/30614994 ID - 30614994 N1 - MTA-SZTE Mikrobiológia és Egészségnevelés Szakmódszertani Kutatócsoport LA - Hungarian DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Gajdács, Márió AU - Marć, Małgorzata Anna AU - Domínguez-Álvarez, Enrique AU - Sanmartín, Carmen TI - Organoselenium Compounds as Novel Adjuvants of Chemotherapy Drugs-A Promising Approach to Fight Cancer Drug Resistance JF - MOLECULES J2 - MOLECULES VL - 24 PY - 2019 IS - 2 PG - 15 SN - 1420-3049 DO - 10.3390/molecules24020336 UR - https://m2.mtmt.hu/api/publication/30409868 ID - 30409868 N1 - Cited By :2 Export Date: 22 August 2019 CODEN: MOLEF Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Chemicals/CAS: Adjuvants, Pharmaceutic; Antineoplastic Agents; Organoselenium Compounds Funding details: Consejo Superior de Investigaciones Científicas Funding details: European Social Fund, 20391-3/2018/FEKUSTRAT Funding details: Ministry of Foreign Affairs and Trade, New Zealand Funding details: 2017/18 Funding details: Fundación Caja Navarra Funding text 1: Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, 6720 Szeged, Hungary; spengler.gabriella@med.u-szeged.hu (G.S.); mariopharma92@gmail.com (M.G.) Interdisciplinary Excellence Centre, Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, 6720 Szeged, Hungary; marcmalgorzata@gmail.com Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), 31008 Pamplona, Spain Correspondence: e.dominguez-alvarez@iqog.csic.es (E.D.-Á.); sanmartin@unav.es (C.S.); Tel.: +34-91-258-7661 (E.D.-Á.); +34-948-425-600 (ext. 806388) (C.S.) These authors contributed equally to this work. Funding text 2: Funding: The authors would like to thank Anikó Váradi Vigyikán for the excellent laboratory assistance. This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. The study was supported by the grant 20391-3/2018/FEKUSTRAT of the Ministry of Human Capacities, Hungary. M.G. and G.S. received funding from the Márton Áron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. M.G. was supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Carmen Sanmartín wishes to express her gratitude to the Uned Pamplona, Fundación Bancaria “La Caixa” y Fundación Caja Navarra, for financial support for the project. Funding Agency and Grant Number: European UnionEuropean Union (EU); State of Hungary; European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.4. A/2-11-1-2012-0001]; Ministry of Human Capacities, Hungary [20391-3/2018/FEKUSTRAT]; Marton Aron Research Programme (2017/18) - Hungarian Ministry of Foreign Affairs and Trade; New National Excellence Program of the Ministry of Human Capacities [UNKP-17-3]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; Uned Pamplona; Fundacion Bancaria "La Caixa"La Caixa Foundation; Fundacion Caja Navarra Funding text: The authors would like to thank Aniko Varadi Vigyikan for the excellent laboratory assistance. This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TAMOP 4.2.4. A/2-11-1-2012-0001 'National Excellence Program'. The study was supported by the grant 20391-3/2018/FEKUSTRAT of the Ministry of Human Capacities, Hungary. M.G. and G.S. received funding from the Marton Aron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. M.G. was supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. G.S. was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Carmen Sanmartin wishes to express her gratitude to the Uned Pamplona, Fundacion Bancaria "La Caixa" y Fundacion Caja Navarra, for financial support for the project. Cited By :16 Export Date: 31 July 2020 CODEN: MOLEF Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Chemicals/CAS: Adjuvants, Pharmaceutic; Antineoplastic Agents; Organoselenium Compounds Funding details: 2017/18 Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: Fundación Caja Navarra Funding details: European Social Fund, ESF, 20391-3/2018/FEKUSTRAT Funding details: European Commission, EC Funding details: Magyar Tudományos Akadémia, MTA Funding details: Fundación Bancaria Caja de Ahorros de Asturias Funding text 1: Funding: The authors would like to thank Anikó Váradi Vigyikán for the excellent laboratory assistance. This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. The study was supported by the grant 20391-3/2018/FEKUSTRAT of the Ministry of Human Capacities, Hungary. M.G. and G.S. received funding from the Márton Áron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. M.G. was supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Carmen Sanmartín wishes to express her gratitude to the Uned Pamplona, Fundación Bancaria “La Caixa” y Fundación Caja Navarra, for financial support for the project. Cited By :21 Export Date: 18 January 2021 CODEN: MOLEF Correspondence Address: Domínguez-Álvarez, E.; Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas (IQOG-CSIC), Juan de la Cierva 3, Spain; email: e.dominguez-alvarez@iqog.csic.es Chemicals/CAS: Adjuvants, Pharmaceutic; Antineoplastic Agents; Organoselenium Compounds Funding details: 2017/18 Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: Fundación Caja Navarra Funding details: European Social Fund, ESF, 20391-3/2018/FEKUSTRAT, A/2-11-1-2012-0001 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Commission, EC Funding details: Fundación Bancaria Ibercaja Funding text 1: Funding: The authors would like to thank Anikó Váradi Vigyikán for the excellent laboratory assistance. This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. The study was supported by the grant 20391-3/2018/FEKUSTRAT of the Ministry of Human Capacities, Hungary. M.G. and G.S. received funding from the Márton Áron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. M.G. was supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Carmen Sanmartín wishes to express her gratitude to the Uned Pamplona, Fundación Bancaria “La Caixa” y Fundación Caja Navarra, for financial support for the project. AB - Malignant diseases present a serious public health burden and their treatment with traditional chemotherapy cannot be considered an all-round solution, due to toxic side effects. Selenium compounds (Se-compounds) have received substantial attention in medicinal chemistry, especially in experimental chemotherapy, both as cytotoxic agents and adjuvants in chemotherapy. A checkerboard microplate method was applied to study the drug interactions of Se-compounds and clinically relevant chemotherapeutic drugs against the multidrug-resistant (MDR) subtype of mouse t-lymphoma cells overexpressing the ABCB1 transporter. Se-compounds showed synergistic interactions with chemotherapeutic agents targeting the topoisomerase enzymes or the microtubule apparatus. The ketone-containing selenoesters showed synergism at lower concentrations (1.25 µM). Most of the tested compounds interacted antagonistically with alkylating agents and verapamil. A thiophene-containing Se-compound showed synergism with all tested drugs, except cisplatin. While the exact mechanism of drug interactions is yet unknown, the potency of the selenocompounds as efflux pump inhibitors or the potentiation of their efficacy as reactive oxygen species modulators may play a role in their complementary activity against the tested MDR lymphoma cell line. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Kovács, Dávid AU - Endrész, Valéria AU - Igaz, Nóra AU - Jenovai, Kitti AU - Spengler, Gabriella AU - Tiszlavicz, László AU - Molnár, József AU - Burián, Katalin AU - Csontné Kiricsi, Mónika AU - Rovó, László TI - Antifibrotic effect of mitomycin-C on human vocal cord fibroblasts JF - LARYNGOSCOPE J2 - LARYNGOSCOPE VL - 129 PY - 2019 IS - 7 SP - E255 EP - E262 PG - 8 SN - 0023-852X DO - 10.1002/lary.27657 UR - https://m2.mtmt.hu/api/publication/30405220 ID - 30405220 N1 - GINOP-2.3.2-15-2016-00040 Department of Oto-Rhino-Laryngology and Head & Neck Surgery, Szeged, Hungary Department of Medical Microbiology and Immunobiology, Szeged, Hungary Department of Pathology, Faculty of Medicine, Szeged, Hungary Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Cited By :2 Export Date: 4 September 2020 CODEN: LARYA Correspondence Address: Szabó, D.; Department of Oto-Rhino-Laryngology and Head & Neck SurgeryHungary; email: diniklinik@freemail.hu Chemicals/CAS: mitomycin, 1404-00-8, 50-07-7, 74349-48-7; ACTA2 protein, human; Actins; Mitomycin; Transforming Growth Factor beta Funding details: GINOP-2.3.2-15-2016-00040 Funding text 1: This study received support from the National Research, Development and Innovation Office-NKFIH (GINOP-2.3.2-15-2016-00040). LA - English DB - MTMT ER - TY - CONF AU - Tatsiana, Petrasheuskaya AU - Orsolya, Dömötör AU - Spengler, Gabriella AU - Annamária, Kincses AU - Kiss, Márton Attila AU - Nagyné Frank, Éva AU - Éva, A. Enyedy TI - Copper(II) complexes of salicylaldehyde thiosemicarbazone and its sterane-based conjugate: solution stability, redox properties and cytotoxicity T2 - ISMEC 2019 International Symposium on Metal Complexes BOOK OF ABSTRACTS PY - 2019 SP - 161 UR - https://m2.mtmt.hu/api/publication/32894008 ID - 32894008 LA - English DB - MTMT ER - TY - JOUR AU - Żesławska, Ewa AU - Kincses, Annamária AU - Spengler, Gabriella AU - Nitek, Wojciech AU - Tejchman, Waldemar AU - Handzlik, Jadwiga TI - Pharmacophoric features for a very potent 5-spirofluorenehydantoin inhibitor of cancer efflux pump ABCB1, based on X-ray analysis JF - CHEMICAL BIOLOGY & DRUG DESIGN J2 - CHEM BIOL DRUG DES VL - 93 PY - 2019 IS - 5 SP - 844 EP - 853 PG - 10 SN - 1747-0277 DO - 10.1111/cbdd.13473 UR - https://m2.mtmt.hu/api/publication/30409869 ID - 30409869 N1 - Department of Chemistry, Institute of Biology, Pedagogical University of Cracow, Kraków, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Faculty of Chemistry, Jagiellonian University, Kraków, Poland Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Kraków, Poland Cited By :8 Export Date: 9 February 2023 CODEN: CBDDA Correspondence Address: Żesławska, E.; Department of Chemistry, Poland; email: ewa.zeslawska@up.krakow.pl Chemicals/CAS: fluorene, 86-73-7; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; fluorene; Fluorenes; Spiro Compounds Funding details: BS-465/G/2018 Funding details: K/ZDS/007886 Funding text 1: The work was partly supported by Pedagogical University of Cracow (BS-465/G/2018) and by Polish Statutory Research Project K/ZDS/007886. Raynaud,J.P.,Bonne,C.,Moguilewsky,M.,Lefebvre,F.A.,Belanger,A.,Labrie,F.,Thepureantiandrogenru23908(anandron®),acandidateofchoiceforthecombinedantihormonaltreatmentofprostaticcancer:Areview(1984)Prostate,5,pp.299-311.,https://doi.org/10.1002/1097-0045 AB - In order to extend knowledge about pharmacophoric features responsible for ABCB1 inhibitory properties of imidazolidin-2,4-dione derivatives, 1'-[4-(4-(o-methoxyphenyl)-piperazin-1-yl)butyl]-3'-methyl-spiro(fluoren-9,5'-imidazolidine)-2',4'-dione (3) and its salt (4) with rhodanine-3-acetic acid (RA) were prepared and investigated by X-ray diffraction method, as well as their efflux modulating effects in cancer cells (mouse T-lymphoma), cytotoxic and antiproliferative activities were evaluated in vitro. The molecular geometry, intermolecular interactions and crystal packing of base and acid forms of 3 were analyzed to see, if conformational changes influence the biological activities. The geometry of 2-methoxyphenylpiperazine and 5-spirofluorenehydantoin moieties was compared with other crystal structures containing these fragments. Our results indicated a very potent inhibitory action on ABCB1 pump, and significant cytotoxic and antiproliferative properties of 3 in T-lymphoma, even more potent in the case of MDR cells. Furthermore, the compound 3 converted into the salt 4 of inactive acid (RA) has maintained both, the efflux pump inhibitory and antiproliferative activities, showing strong synergism with doxorubicin. A comparison of geometry of 3 in both crystal structures (3 and 4) shows a significant difference in the arrangement of piperazine ring with respect to the aliphatic linker. This article is protected by copyright. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Ahmad, Mouwakeh AU - Telbisz, Ágnes Mária AU - Spengler, Gabriella AU - Mohácsiné Farkas, Csilla AU - Kiskó, Gabriella TI - Antibacterial and Resistance Modifying Activities of Nigella sativa Essential Oil and its Active Compounds Against Listeria monocytogenes JF - IN VIVO J2 - IN VIVO VL - 32 PY - 2018 IS - 4 SP - 737 EP - 743 PG - 7 SN - 0258-851X DO - 10.21873/invivo.11302 UR - https://m2.mtmt.hu/api/publication/3389574 ID - 3389574 LA - English DB - MTMT ER - TY - CONF AU - Kincses, Annamária AU - Orsolya, Vásárhelyi AU - Nové, Márta AU - Klaudia, Vincze AU - Zsoldiné Urbán, Edit AU - Spengler, Gabriella TI - Evaluation of antibiotic susceptibility of urinary tract pathogens depending on the pH T2 - 28th European Congress of Clinical Microbiology and Infectious Diseases (28th ECCMID) PB - European Society of Clinical Microbiology and Infectious Diseases (ESCMID) C1 - Madrid PY - 2018 PG - 1 UR - https://m2.mtmt.hu/api/publication/3375678 ID - 3375678 LA - English DB - MTMT ER - TY - CONF AU - Kincses, Annamária AU - ORSOLYA, VÁSÁRHELYI AU - Nové, Márta AU - Zsoldiné Urbán, Edit AU - Spengler, Gabriella TI - THE ROLE OF PH REGARDING ANTIBIOTIC SUSCEPTIBILITY OF URINARY TRACT PATHOGENS T2 - A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium PB - Magyar Mikrobiológiai Társaság (MMT) C1 - Budapest PY - 2018 SP - 31 UR - https://m2.mtmt.hu/api/publication/30424629 ID - 30424629 LA - English DB - MTMT ER - TY - JOUR AU - Bourichi, S AU - Misbahi, H AU - Rodi, YK AU - Chahdi, FO AU - Essassi, EM AU - Szabo, S AU - Szalontai, B AU - Gajdács, Márió AU - Molnár, József AU - Spengler, Gabriella TI - In Vitro Evaluation of the Multidrug Resistance Reversing Activity of Novel Imidazo[4,5-b]pyridine Derivatives. JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 38 PY - 2018 IS - 7 SP - 3999 EP - 4003 PG - 5 SN - 0250-7005 DO - 10.21873/anticanres.12687 UR - https://m2.mtmt.hu/api/publication/3393151 ID - 3393151 N1 - Acknowledgements This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Márió Gajdács and Gabriella Spengler received funding from the Márton Áron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. Márió Gajdács was supported by the ÚNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. The study was supported by the Szeged Foundation for Cancer Research. Laboratory of Heterocyclic Organic Chemistry URAC21, Faculty of Sciences, University of Mohamed V, Rabat, Morocco Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Laboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, BP 2202, Fez, Morocco Cited By :1 Export Date: 22 August 2019 CODEN: ANTRD Correspondence Address: Misbahi, H.; Laboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, BP 2202, Morocco; email: houriya.misbahi@usmba.ac.ma Chemicals/CAS: verapamil, 152-11-4, 52-53-9; rhodamine 123, 62669-70-9; imidazo(4,5-b)pyridine; Imidazoles; Pyridines; Rhodamine 123 Funding details: European Social Fund Funding details: Ministry of Foreign Affairs and Trade, New Zealand Funding details: 2017/18 Funding text 1: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Márió Gajdács and Gabriella Spengler received funding from the Márton Áron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. Márió Gajdács was supported by the ÚNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. The study was supported by the Szeged Foundation for Cancer Research. Funding Agency and Grant Number: European UnionEuropean Union (EU); European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.4. A/2-11-1-2012-0001]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; Marton Aron Research Programme - Hungarian Ministry of Foreign Affairs and Trade [2017/18]; New National Excellence Program of the Ministry of Human Capacities [UNKP-17-3]; Szeged Foundation for Cancer Research; State of Hungary Funding text: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TAMOP 4.2.4. A/2-11-1-2012-0001 'National Excellence Program'. Gabriella Spengler was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Mario Gajdacs and Gabriella Spengler received funding from the Marton Aron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. Mario Gajdacs was supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. The study was supported by the Szeged Foundation for Cancer Research. Laboratory of Heterocyclic Organic Chemistry URAC21, Faculty of Sciences, University of Mohamed V, Rabat, Morocco Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Laboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, BP 2202, Fez, Morocco Cited By :2 Export Date: 31 July 2020 CODEN: ANTRD Correspondence Address: Misbahi, H.; Laboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, BP 2202, Morocco; email: houriya.misbahi@usmba.ac.ma Chemicals/CAS: verapamil, 152-11-4, 52-53-9; rhodamine 123, 62669-70-9; imidazo(4,5-b)pyridine; Imidazoles; Pyridines; Rhodamine 123 Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: European Social Fund, ESF Funding details: European Commission, EC Funding details: Magyar Tudományos Akadémia, MTA, 2017/18 Funding text 1: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Márió Gajdács and Gabriella Spengler received funding from the Márton Áron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. Márió Gajdács was supported by the ÚNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. The study was supported by the Szeged Foundation for Cancer Research. Laboratory of Heterocyclic Organic Chemistry URAC21, Faculty of Sciences, University of Mohamed V, Rabat, Morocco Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Laboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, BP 2202, Fez, Morocco Cited By :4 Export Date: 18 January 2021 CODEN: ANTRD Correspondence Address: Misbahi, H.; Laboratory of Applied Organic Chemistry, Faculty of Science and Technology, Sidi Mohamed Ben Abdellah University, BP 2202, Morocco; email: houriya.misbahi@usmba.ac.ma Chemicals/CAS: verapamil, 152-11-4, 52-53-9; rhodamine 123, 62669-70-9; imidazo(4,5-b)pyridine; Imidazoles; Pyridines; Rhodamine 123 Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: European Social Fund, ESF, A/2-11-1-2012-0001 Funding details: Magyar Tudományos Akadémia, MTA, 2017/18 Funding details: European Commission, EC Funding text 1: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Márió Gajdács and Gabriella Spengler received funding from the Márton Áron Research Programme (2017/18) financed by the Hungarian Ministry of Foreign Affairs and Trade. Márió Gajdács was supported by the ÚNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. The study was supported by the Szeged Foundation for Cancer Research. AB - BACKGROUND/AIM: Malignant diseases present a significant public health burden worldwide and their treatment is further complicated by the phenomenon of multidrug resistance. Derivatives of imidazopyridine exhibit several remarkable pharmacological activities and they could reverse the multidrug resistance of cancer cells due to overexpressing P-glycoprotein. MATERIALS AND METHODS: A series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their biological activities were evaluated in vitro using parental (PAR) and multidrug resistant (MDR; ABCB1-overexpressing) mouse T-lymphoma cells. The cytotoxic activity and selectivity of the tested compounds were assessed by the thiazolyl blue tetrazolium bromide (MTT) assay, the ABCB1 modulating activity was measured by rhodamine 123 accumulation assay using flow cytometry. RESULTS: Six compounds (b, c, d, f, h and i) showed moderate-to-high cytotoxic activity on the tested cell lines, while derivative i presented with promising selectivity towards the MDR cell line. Derivatives a, d, f, g and i were proven to be effective modulators of the ABCB1 multidrug efflux pump, with two compounds showing efflux pump modulatory activity at 2 muM concentration. CONCLUSION: Based on our experimental results, compounds that showed potent activity are those with a short carbon side chain; a methoxy group on the benzene ring; a heterocyclic (triazole) side chain and the presence of an alkylated N-atom at position 4. LA - English DB - MTMT ER - TY - JOUR AU - Burián, Katalin AU - Spengler, Gabriella AU - Mosolygó, Tímea TI - A szexuális úton átvihető, szisztémás megbetegedést okozó mikroorganizmusok ismerete középiskolai pedagógusok számára 2. rész Knowledge of the sexually transmitted microorganisms causing systemic diseases for high school teachers JF - EGÉSZSÉGFEJLESZTÉS J2 - EGÉSZSÉGFEJLESZTÉS VL - 59 PY - 2018 IS - 6 SP - 14 EP - 20 PG - 7 SN - 1786-2434 DO - 10.24365/ef.v59i6.353 UR - https://m2.mtmt.hu/api/publication/30434556 ID - 30434556 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ferreira, Ricardo J. AU - Kincses, Annamária AU - Gajdács, Márió AU - Spengler, Gabriella AU - dos, Santos Daniel J. V. A. AU - Molnár, József AU - Ferreira, Maria-Jose U. TI - Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 81 PY - 2018 IS - 9 SP - 2032 EP - 2040 PG - 9 SN - 0163-3864 DO - 10.1021/acs.jnatprod.8b00326 UR - https://m2.mtmt.hu/api/publication/30378624 ID - 30378624 N1 - IMed.ULisboa (Research Institute for Medicines), Faculty of Pharmacy, Universidade de Lisboa, Avenida Prof. Gama Pinto, Lisboa, 1649-003, Portugal Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary LAQV at REQUIMTE/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre, Porto, 4169-007, Portugal Molecular Biophysics, Department of Cell and Molecular Biology, Uppsala Biomedicinska Centrum BMC, Husargatan 3, Uppsala, 751 24, Sweden Export Date: 22 August 2019 CODEN: JNPRD Correspondence Address: Ferreira, M.-J.U.; IMed.ULisboa (Research Institute for Medicines), Faculty of Pharmacy, Universidade de Lisboa, Avenida Prof. Gama Pinto, Portugal; email: mjuferreira@ff.ulisboa.pt Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; doxorubicin, 23214-92-8, 25316-40-9; oleanolic acid, 508-02-1; verapamil, 152-11-4, 52-53-9 Funding details: China National Funds for Distinguished Young Scientists Funding details: Fundação para a Ciência e a Tecnologia Funding details: GINOP-2.3.2-15-2016-00012, SFRH/BD/84285/ 2012, UID/DTP/04138/2013, PTDC/ QEQMED/0905/2012, SAICT-PAC/0019/2015, PTDC/MED-QUI/30591/2017 Funding text 1: This project received funding from European Structural & Investment Funds through the COMPETE Programme and from National Funds through FCT, Fundaca̧ õ para a Cienciâ e a Tecnologia, under the Programme grants PTDC/ QEQMED/0905/2012, UID/DTP/04138/2013, SAICT-PAC/0019/2015, and PTDC/MED-QUI/30591/2017. R.J.F. acknowledges FCT for the Ph.D. grant SFRH/BD/84285/ 2012. The study was also supported by the project GINOP-2.3.2-15-2016-00012. We also acknowledge Dr. T. Vasconcelos, ISA, Universidade de Lisboa, for plant material identification. LA - English DB - MTMT ER - TY - CONF AU - Spengler, Gabriella AU - Gajdács, Márió AU - Kincses, Annamária AU - Nové, Márta AU - Berta, Barta Holló AU - Mosolygó, Tímea AU - Burián, Katalin AU - Katalin, Mészáros Szécsényi TI - Hydrazone-based transition metal complexes as novel antiviral agents and antibiotic adjuvants: an in vitro study T2 - 28th European Congress of Clinical Microbiology and Infectious Diseases (28th ECCMID) PB - European Society of Clinical Microbiology and Infectious Diseases (ESCMID) C1 - Madrid PY - 2018 PG - 1 UR - https://m2.mtmt.hu/api/publication/3375888 ID - 3375888 LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Jadwiga, Handzlik AU - Carmen, Sanmartín AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella TI - Rákellenes és efflux pumpa gátló hatású szelénvegyületek ADME tulajdonságainak becslése számítógépes módszerrel [Prediction of ADME properties for selenocompounds with anticancer and efflux pump inhibitory activity using preliminary computational methods] JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 88 PY - 2018 IS - 2 SP - 67 EP - 73 PG - 7 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/3399647 ID - 3399647 N1 - Köszönetnyilvánítás A kutatás az Emberi Erőforrások Minisztériuma UNKP-17-3 kódszámú Új Nemzeti Kiválóság Programjának támogatásával készült. Spengler Gabriella Bolyai János Ösztöndíjban részesül. A kutatásunkat a TÁMOP-4.2.2.A-11/ 1KONV-2012- 0035 és TÁMOP-4.2.4.A/2-11/1/2012-0001 pályázatok és a Balassi Intézet Kutatói Program (2017/18) támogatta. SZTE ÁOK, Orvosi Mikrobiológiai és Immunbiológiai Intézet, Dóm tér 10, Szeged, 6720, Hungary Jagelló Egyetem Orvostudományi Kar, Gyógyszertechnológiai és Biotechnológiai Tanszék, Medyczna 9, Krakkó, 30-688, Hungary Navarrai Egyetem Gyógyszerkémiai Intézet, Irunlarrea 1, Pamplona, 31010, Spain Spanyol Nemzeti Kutatási Tanács, Szerves Kémiai Intézet, Juan de la Cierva 3, Madrid, 28006, Spain Cited By :4 Export Date: 22 August 2019 CODEN: APHGA Chemicals/CAS: octanol, 111-87-5, 29063-28-3; water, 7732-18-5 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Jadwiga, Handzlik AU - Carmen, Sanmartín AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella TI - Szerves szelénvegyületek mint daganatellenes szerek: kísérleti eredmények in vitro vastagbél adenokarcinóma modellen [Organoselenium compounds as antitumor agents: In vitro evaluation on a colon cancer model system] JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 88 PY - 2018 IS - 2 SP - 59 EP - 65 PG - 7 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/3399645 ID - 3399645 N1 - Köszönetnyilvánítás A közlemény szerzői szeretnénk köszönetét mondani Vigyikánné Váradi Anikónak, a kísérletek elvégzésében és a laboratóriumi előkészítésben nyújtott segítségéért. Köszönjük Dr. Ocsovszki Imre segítségét az áramlási citometriás vizsgálatok elvégzésénél és az eredmények kiértékelésénél. Köszönjük prof. dr. Juan Antonio Palop-nak a vegyületek szintézise és szerkezetigazolása során nyújtott segítségét. A kutatás az Emberi Erőforrások Minisztériuma UNKP-17-3 kódszámú Új Nemzeti Kiválóság Programjának támogatásával készült. Spengler Gabriella Bolyai János Ösztöndíjban részesül. A kutatásunkat a TÁMOP-4.2.2.A-11/1KONV-2012-0035 és TÁMOP-4.2.4.A/2-11/1/2012-0001 pályázatok és a Balassi Intézet Kutatói Program támogatta. SZTE ÁOK, Orvosi Mikrobiológiai és Immunbiológiai Intézet, Dóm tér 10, Szeged, 6720, Hungary Jagelló Egyetem Orvostudományi Kar, Gyógyszertechnológiai és Biotechnológiai Tanszék, Medyczna 9, Krakkó, 30-688, Hungary Navarrai Egyetem Gyógyszerkémiai Intézet, Irunlarrea 1, Pamplona, 31010, Spain Spanyol Nemzeti Kutatási Tanács, Szerves Kémiai Intézet, Juan de la Cierva 3, Madrid, 28006, Spain Cited By :1 Export Date: 22 August 2019 CODEN: APHGA Chemicals/CAS: rhodamine 123, 62669-70-9; verapamil, 152-11-4, 52-53-9 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Gajdács, Márió AU - Domínguez-Álvarez, Enrique AU - Spengler, Gabriella ED - Keresztes, Gábor TI - Antitumor activity of organoselenium compounds against specific tumor types with significant mortality in Hungary T2 - Tavaszi Szél 2018 Konferencia. Nemzetközi Multidiszciplináris Konferencia PB - Doktoranduszok Országos Szövetsége (DOSZ) CY - Budapest SN - 9786155586262 PY - 2018 SP - 389 EP - 389 PG - 1 UR - https://m2.mtmt.hu/api/publication/3376303 ID - 3376303 N1 - The study was supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. LA - English DB - MTMT ER - TY - CHAP AU - Gajdács, Márió AU - Kincses, Annamária AU - Nové, Márta AU - Unger, Vivien AU - Tóth, Viktor AU - Barta, Holló Berta AU - Magyari, József AU - Molnár, József AU - Mészáros, Szécsényi Katalin AU - Spengler, Gabriella ED - Keresztes, Gábor TI - Schiff-bázis típusú ligandokkal rendelkező átmenetifém-komplexek daganatellenes hatásának vizsgálata T2 - Tavaszi Szél 2018 Konferencia. Nemzetközi Multidiszciplináris Konferencia PB - Doktoranduszok Országos Szövetsége (DOSZ) CY - Budapest SN - 9786155586262 PY - 2018 SP - 388 EP - 388 PG - 1 UR - https://m2.mtmt.hu/api/publication/3376302 ID - 3376302 N1 - A kutatás az Emberi Erőforrások Minisztériuma ÚNKP-17-3 kódszámú Új Nemzeti Kiválóság Programjának támogatásával készült. Spengler Gabriellát a Bolyai János Kutatási Ösztöndíj támogatta. A kutatás létrejöttét a GINOP-2.3.2-15-2016-00038 pályázat támogatta. LA - Hungarian DB - MTMT ER - TY - CONF AU - Mottaghipisheh, Javad AU - Spengler, Gabriella AU - Nové, Márta AU - Kúsz, Norbert AU - Hohmann, Judit AU - Csupor, Dezső TI - Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia T2 - Young Scientists' Meeting on Advances in Phytochemical Analysis PY - 2018 PG - 1 UR - https://m2.mtmt.hu/api/publication/3396274 ID - 3396274 LA - English DB - MTMT ER - TY - JOUR AU - József, Magyari AU - Berta, Barta Holló AU - Ljiljana, S Vojinović-Ješić AU - Mirjana, M Radanović AU - Stevan, Armaković AU - Sanja, J Armaković AU - Molnár, József AU - Kincses, Annamária AU - Gajdács, Márió AU - Spengler, Gabriella AU - Katalin, Mészáros Szécsényi TI - Interactions of Schiff base compounds and their coordination complexes with the drug cisplatin JF - NEW JOURNAL OF CHEMISTRY J2 - NEW J CHEM VL - 42 PY - 2018 IS - 8 SP - 5834 EP - 5843 PG - 10 SN - 1144-0546 DO - 10.1039/c8nj00357b UR - https://m2.mtmt.hu/api/publication/3368729 ID - 3368729 N1 - Acknowledgements The synthesis of the compounds was financed by the Ministry of Education, Science and Technological Development of Serbia, grant number ON172014. The computational part of this work was performed thanks to the support received from Schrodinger Inc. Part of this study was performed within the project funded by the Ministry of Education, Science and Technological Development of Serbia, grant number III41017. Gabriella Spengler was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamaria Kincses and Mario Gajdács were supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. This study was supported by the project GINOP-2.3.2-15-2016-00038. University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, Novi Sad, 21000, Serbia University of Novi Sad, Faculty of Sciences, Department of Physics, Trg Dositeja Obradovića 4, Novi Sad, 21000, Serbia University of Szeged, Faculty of Medicine, Department of Medical Microbiology and Immunobiology, Dóm tér 10, Szeged, H-6720, Hungary Cited By :5 Export Date: 22 August 2019 CODEN: NJCHE Correspondence Address: Meszaros Szecsenyi, K.; University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, Serbia; email: mszk@uns.ac.rs Chemicals/CAS: aminoguanidine, 1068-42-4, 2582-30-1, 79-17-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; copper, 15158-11-9, 7440-50-8 Funding details: ON172014 Funding details: Magyar Tudományos Akadémia, MTA Funding details: GINOP-2.3.2-15-2016-00038 Funding details: III41017 Funding text 1: The synthesis of the compounds was financed by the Ministry of Education, Science and Technological Development of Serbia, grant number ON172014. The computational part of this work was performed thanks to the support received from Schrödinger Inc. Part of this study was performed within the project funded by the Ministry of Education, Science and Technological Development of Serbia, grant number III41017. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses and Márió Gajdács were supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. This study was supported by the project GINOP-2.3.2-15-2016-00038. Funding Agency and Grant Number: Ministry of Education, Science and Technological Development of Serbia [ON172014, III41017]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences; New National Excellence Program of the Ministry of Human Capacities [UNKP-17-3]; [GINOP-2.3.2-15-2016-00038] Funding text: The synthesis of the compounds was financed by the Ministry of Education, Science and Technological Development of Serbia, grant number ON172014. The computational part of this work was performed thanks to the support received from Schrodinger Inc. Part of this study was performed within the project funded by the Ministry of Education, Science and Technological Development of Serbia, grant number III41017. Gabriella Spengler was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamaria Kincses and Mario Gajdacs were supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. This study was supported by the project GINOP-2.3.2-15-2016-00038. University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, Novi Sad, 21000, Serbia University of Novi Sad, Faculty of Sciences, Department of Physics, Trg Dositeja Obradovića 4, Novi Sad, 21000, Serbia University of Szeged, Faculty of Medicine, Department of Medical Microbiology and Immunobiology, Dóm tér 10, Szeged, H-6720, Hungary Cited By :7 Export Date: 31 July 2020 CODEN: NJCHE Correspondence Address: Meszaros Szecsenyi, K.; University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, Serbia; email: mszk@uns.ac.rs Chemicals/CAS: aminoguanidine, 1068-42-4, 2582-30-1, 79-17-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; copper, 15158-11-9, 7440-50-8 Funding details: Emberi Eroforrások Minisztériuma, EMMI, GINOP-2.3.2-15-2016-00038 Funding details: Ministarstvo Prosvete, Nauke i TehnoloÅ¡kog Razvoja, MPNTR, III41017, ON172014 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The synthesis of the compounds was financed by the Ministry of Education, Science and Technological Development of Serbia, grant number ON172014. The computational part of this work was performed thanks to the support received from Schrödinger Inc. Part of this study was performed within the project funded by the Ministry of Education, Science and Technological Development of Serbia, grant number III41017. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses and Márió Gajdács were supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. This study was supported by the project GINOP-2.3.2-15-2016-00038. University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, Novi Sad, 21000, Serbia University of Novi Sad, Faculty of Sciences, Department of Physics, Trg Dositeja Obradovića 4, Novi Sad, 21000, Serbia University of Szeged, Faculty of Medicine, Department of Medical Microbiology and Immunobiology, Dóm tér 10, Szeged, H-6720, Hungary Cited By :9 Export Date: 18 January 2021 CODEN: NJCHE Correspondence Address: Meszaros Szecsenyi, K.; University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, Serbia; email: mszk@uns.ac.rs Chemicals/CAS: aminoguanidine, 1068-42-4, 2582-30-1, 79-17-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; copper, 15158-11-9, 7440-50-8 Funding details: Emberi Eroforrások Minisztériuma, EMMI, GINOP-2.3.2-15-2016-00038 Funding details: Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja, MPNTR, III41017, ON172014 Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The synthesis of the compounds was financed by the Ministry of Education, Science and Technological Development of Serbia, grant number ON172014. The computational part of this work was performed thanks to the support received from Schrödinger Inc. Part of this study was performed within the project funded by the Ministry of Education, Science and Technological Development of Serbia, grant number III41017. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses and Márió Gajdács were supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. This study was supported by the project GINOP-2.3.2-15-2016-00038. LA - English DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Varga, Borisz AU - Csonka, Ákos AU - Sancha, S AU - Mulhovo, S AU - Madureira, AM AU - Ferreira, MU AU - Spengler, Gabriella TI - Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria JF - PHYTOTHERAPY RESEARCH J2 - PHYTOTHER RES VL - 32 PY - 2018 IS - 6 SP - 1039 EP - 1046 PG - 8 SN - 0951-418X DO - 10.1002/ptr.6042 UR - https://m2.mtmt.hu/api/publication/3340031 ID - 3340031 N1 - ACKNOWLEDGEMENTS This research was supported by the European Union and the State of Hungary and by the Portuguese Foundation for Science and Technology (FCT), Projects PTDC/QEQ‐MED/0905/2012 and UID/DTP/04138/2013, and co‐financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2‐11‐1‐2012‐0001 “National Excellence Program.” This study was supported by the GINOP‐2.3.2‐15‐2016‐00012 project (University of Szeged, Hungary), and Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Annamária Kincses was supported by the ÚNKP‐17‐3 New National Excellence Program of the Ministry of Human Capacities of Hungary. The authors thank the Portuguese Embassy in Mozambique, as well as the Portuguese Office of International Affairs, for plant transport. AB - Cleistochlamys kirkii (Benth) Oliv. (Annonaceae) is a medicinal plant traditionally used in Mozambique to treat infectious diseases. The aim of this study was to find resistance modifiers in C. kirkii for Gram-positive and Gram-negative model bacterial strains. One of the most important resistance mechanisms in bacteria is the efflux pump-related multidrug resistance. Therefore, polycarpol (1), three C-benzylated flavanones (2-4), and acetylmelodorinol (5) were evaluated for their multidrug resistance-reverting activity on methicillin-susceptible and methicillin-resistant Staphylococcus aureus and Escherichia coli AG100 and AG100 A strains overexpressing and lacking the AcrAB-TolC efflux pump system. The combined effects of antibiotics and compounds (2 and 4) were also assessed by using the checkerboard microdilution method in both S. aureus strains. The relative gene expression of the efflux pump genes was determined by real-time reverse transcriptase quantitative polymerase chain reaction. The inhibition of quorum sensing was also investigated. The combined effect of the antibiotics and compound 2 or 4 on the methicillin-sensitive S. aureus resulted in synergism. The most active compounds 2 and 4 increased the expression of the efflux pump genes. These results suggested that C. kirkii constituents could be effective adjuvants in the antibiotic treatment of infections. LA - English DB - MTMT ER - TY - CONF AU - Fási, Laura AU - Gyovai, András AU - Zupkó, István AU - Nové, Márta AU - Spengler, Gabriella AU - Fang-Rong, Chang AU - Hunyadi, Attila TI - Semi-synthetic preparation of antitumor p-coumaric acid derivatives T2 - GA2018: The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA); S-TCM 2018 : The 11th Shanghai International Conference on Traditional Chinese Medicine and Natural Medicine PY - 2018 UR - https://m2.mtmt.hu/api/publication/3426792 ID - 3426792 N1 - [poszter] LA - English DB - MTMT ER - TY - CONF AU - Gajdács, Márió AU - Szegedi, Ernő AU - Molnár, József AU - Spengler, Gabriella TI - Pharmaceutical Compounds as Quorum Sensing (QS) Inhibitors T2 - A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium PB - Magyar Mikrobiológiai Társaság (MMT) C1 - Budapest PY - 2018 SP - 19 EP - 19 PG - 1 UR - https://m2.mtmt.hu/api/publication/30424623 ID - 30424623 LA - English DB - MTMT ER - TY - CONF AU - Gajdács, Márió AU - Dorota, Łażewska AU - Katarzyna, Kieć-Kononowicz AU - Carmen, Sanmartín AU - Jadwiga, Handzlik AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella TI - Quorum Sensing Inhibition by Sulfur and Selenium-Containing Organochalcogens: A Comparative In Vitro Study T2 - A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium PB - Magyar Mikrobiológiai Társaság (MMT) C1 - Budapest PY - 2018 SP - 18 EP - 19 PG - 2 UR - https://m2.mtmt.hu/api/publication/30424613 ID - 30424613 LA - English DB - MTMT ER - TY - CONF AU - Nové, Márta AU - Kincses, Annamária AU - Mosolygó, Tímea AU - AYMAN, EL-FAROUKI AU - Magyari, József AU - BERTA, HOLLÓ BARTA AU - Burián, Katalin AU - KATALIN, SZÉCSÉNYI MÉSZÁROS AU - Spengler, Gabriella TI - ANTIBACTERIAL EFFECT OF DIAZINE-RING CONTAINING HYDRAZONES AND THEIR METAL COMPLEXES T2 - A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium PB - Magyar Mikrobiológiai Társaság (MMT) C1 - Budapest PY - 2018 SP - 47 UR - https://m2.mtmt.hu/api/publication/30424635 ID - 30424635 LA - English DB - MTMT ER - TY - JOUR AU - Mottaghipisheh, Javad AU - Nové, Márta AU - Spengler, Gabriella AU - Kúsz, Norbert AU - Hohmann, Judit AU - Csupor, Dezső TI - Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia JF - PHARMACEUTICAL BIOLOGY J2 - PHARM BIOL VL - 56 PY - 2018 IS - 1 SP - 658 EP - 664 PG - 7 SN - 1388-0209 DO - 10.1080/13880209.2018.1548625 UR - https://m2.mtmt.hu/api/publication/30426802 ID - 30426802 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office [OTKA K115796]; Economic Development and Innovation Operative Programme [GINOP-2.3.2-15-2016-00012, EFOP 3.6.3-VEKOP-16-2017-00009]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences Funding text: This work was supported by the National Research, Development and Innovation Office (OTKA K115796), Economic Development and Innovation Operative Programme GINOP-2.3.2-15-2016-00012, EFOP 3.6.3-VEKOP-16-2017-00009 and Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. LA - English DB - MTMT ER - TY - CONF AU - Mottaghipisheh, Javad AU - Nové, Márta AU - Spengler, Gabriella AU - Kúsz, Norbert AU - Hohmann, Judit AU - Csupor, Dezső ED - Csupor, Dezső ED - Rédei, Dóra ED - Kiss, Tivadar TI - Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia T2 - Fiatal Gyógynövénykutatók Fóruma: A Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztályának tudományos konferenciája PB - Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztálya C1 - Szeged PY - 2018 SP - 10 EP - 10 PG - 1 DO - 10.14232/fgykf.2018.b1 UR - https://m2.mtmt.hu/api/publication/30344882 ID - 30344882 LA - English DB - MTMT ER - TY - CONF AU - Ahmad, MOUWAKEH AU - Telbisz, A AU - Spengler, Gabriella AU - Mohácsiné Farkas, Csilla AU - Kiskó, Gabriella TI - Antimicrobial activity and mode of action of Nigella sativa against L. monocytogenes T2 - Book of Abstracts PY - 2018 SP - 94 EP - 95 PG - 2 UR - https://m2.mtmt.hu/api/publication/3375914 ID - 3375914 LA - English DB - MTMT ER - TY - CHAP AU - Mouwakeh, A. AU - Kincses, Annamária AU - Nové, Márta AU - Mosolygó, Tímea AU - Spengler, Gabriella AU - Telbisz, Á. AU - Mohácsiné Farkas, Csilla AU - Kiskó, Gabriella TI - The antimicrobial and resistance modifying activities of Nigella sativa oil T2 - Third International Conference on Food Science and Technology PB - Szent István Egyetem, Élelmiszertudományi Kar CY - Budapest SN - 9789632697949 PY - 2018 SP - 66 UR - https://m2.mtmt.hu/api/publication/30811859 ID - 30811859 LA - English DB - MTMT ER - TY - JOUR AU - Nagyné Kovács, Teodóra AU - Studnicka, L AU - Kincses, Annamária AU - Spengler, Gabriella AU - Molnár, Mónika AU - Tolner, Mária AU - Lukács, István Endre AU - Szilágyi, Imre Miklós AU - Pokol, György TI - Synthesis and characterization of Sr and Mg-doped hydroxyapatite by a simple precipitation method JF - CERAMICS INTERNATIONAL J2 - CERAM INT VL - 44 PY - 2018 IS - 18 SP - 22976 EP - 22982 PG - 7 SN - 0272-8842 DO - 10.1016/j.ceramint.2018.09.096 UR - https://m2.mtmt.hu/api/publication/3415888 ID - 3415888 LA - English DB - MTMT ER - TY - JOUR AU - Poljarević, Jelena M AU - Gál, Gyula Tamás AU - May, Nóra Veronika AU - Spengler, Gabriella AU - Dömötör, Orsolya AU - Savić, Aleksandar R AU - Grgurić-Šipka, Sanja AU - Enyedy, Éva Anna TI - Comparative solution equilibrium and structural studies of half-sandwich ruthenium(II)(η6-toluene) complexes of picolinate derivatives JF - JOURNAL OF INORGANIC BIOCHEMISTRY J2 - J INORG BIOCHEM VL - 181 ET - 0 PY - 2018 SP - 74 EP - 85 PG - 12 SN - 0162-0134 DO - 10.1016/j.jinorgbio.2017.12.017 UR - https://m2.mtmt.hu/api/publication/3311971 ID - 3311971 N1 - N1 CAPLUS AN 2018:240640(Journal; Online Computer File) Acknowledgements: This work was supported by the National Research, Developmentand Innovation Office-NKFIA through projects GINOP-2.3.2-15-2016-00038, FK 124240, K 115762, the UNKP-17-4 New National Excellence Program of the Ministry of Human Capacities (E.A.E. and O.D.), the J.Bolyai Research Scholarship of the Hungarian Academy of Sciences(N.V.M.) and the Ministry of Education, Science and TechnologicalDevelopment of the Republic of Serbia (MPNTR 172035 and PNTRpostdoctoral grant (J. M. P.)). The authors thank Prof. Vladimir B. Arion(University of Vienna) for the elementary analysis of the complexes. Funding Agency and Grant Number: National Research, Development and Innovation Office-NKFIA [GINOP-2.3.2-15-2016-00038, FK 124240, K 115762]; Ministry of Human Capacities [UNKP-17-4]; Hungarian Academy of SciencesHungarian Academy of Sciences; Ministry of Education, Science and Technological Development of the Republic of Serbia [MPNTR 172035]; Ministry of Education, Science and Technological Development of the Republic of Serbia (MPNTR postdoctoral grant) Funding text: This work was supported by the National Research, Development and Innovation Office-NKFIA through projects GINOP-2.3.2-15-2016-00038, FK 124240, K 115762, the UNKP-17-4 New National Excellence Program of the Ministry of Human Capacities (E.A.E. and O.D.), the J. Bolyai Research Scholarship of the Hungarian Academy of Sciences (N.V.M.) and the Ministry of Education, Science and Technological Development of the Republic of Serbia (MPNTR 172035 and MPNTR postdoctoral grant (J. M. P.)). The authors thank Prof. Vladimir B. Anion (University of Vienna) for the elementary analysis of the complexes. LA - English DB - MTMT ER - TY - JOUR AU - Rédei, Dóra AU - Kúsz, Norbert AU - Sátori, Gréta AU - Kincses, Annamária AU - Spengler, Gabriella AU - Burián, Katalin AU - Barina, Zoltán AU - Hohmann, Judit TI - Bioactive Segetane, Ingenane, and Jatrophane Diterpenes from Euphorbia taurinensis JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 84 PY - 2018 IS - 9-10 SP - 729 EP - 735 PG - 7 SN - 0032-0943 DO - 10.1055/a-0589-0525 UR - https://m2.mtmt.hu/api/publication/3351673 ID - 3351673 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Kincses, Annamária AU - Rácz, Bálint AU - Varga, Borisz AU - Watanabe, Genki AU - Saijo, Ryosuke AU - Sekiya, Hiroshi AU - Tamai, Eiji AU - Maki, Jun AU - Molnár, József AU - Kawase, Masami TI - Benzoxazole-based Zn(II) and Cu(II) Complexes Overcome Multidrug-resistance in Cancer JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 38 PY - 2018 IS - 11 SP - 6181 EP - 6187 PG - 7 SN - 0250-7005 DO - 10.21873/anticanres.12971 UR - https://m2.mtmt.hu/api/publication/30378623 ID - 30378623 N1 - Acknowledgements:This research was supported by the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, cofinanced by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. Gabriella Spengler was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. This study was supported by the project GINOP-2.3.2-15-2016-00038. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Kovács, Dávid AU - Endrész, Valéria AU - Igaz, Nóra AU - Spengler, Gabriella AU - Csontné Kiricsi, Mónika AU - Tiszlavicz, László AU - Rovó, László TI - Mitomycin-C fibrosisgátló hatása humán primer hangszalag-fibrolastokon - felső légúti hegesedések kezelésének új lehetősége JF - FÜL-ORR-GÉGEGYÓGYÁSZAT J2 - FÜL-ORR-GÉGEGYÓGYÁSZAT VL - 64 PY - 2018 IS - 3 SP - 110 EP - 110 PG - 1 SN - 0016-237X UR - https://m2.mtmt.hu/api/publication/31402136 ID - 31402136 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Zeslawska, E AU - Kincses, Annamária AU - Unger, V AU - Toth, V AU - Spengler, Gabriella AU - Nitek, W AU - Tejchman, W TI - Exocyclic Sulfur and Selenoorganic Compounds Towards Their Anticancer Effects: Crystallographic and Biological Studies JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 38 PY - 2018 IS - 8 SP - 4577 EP - 4584 PG - 8 SN - 0250-7005 DO - 10.21873/anticanres.12762 UR - https://m2.mtmt.hu/api/publication/3411679 ID - 3411679 N1 - Acknowledgements The Authors would like to thank Prof. Jadwiga Handzlik for her comprehensive discussion. The work was supported by Pedagogical University of Cracow (BS-465/G/2018). Funding Agency and Grant Number: Pedagogical University of Cracow [BS-465/G/2018] Funding text: The Authors would like to thank Prof. Jadwiga Handzlik for her comprehensive discussion. The work was supported by Pedagogical University of Cracow (BS-465/G/2018). Department of Chemistry, Institute of Biology, Pedagogical University of Cracow, Podchorazych 2, Kraków, 30-084, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Faculty of Chemistry, Jagiellonian University, Kraków, Poland Cited By :5 Export Date: 31 July 2020 CODEN: ANTRD Correspondence Address: Zesławska, E.; Department of Chemistry, Institute of Biology, Pedagogical University of Cracow, Podchorazych 2, Poland; email: ewa.zeslawska@up.krakow.pl Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; selenium, 7782-49-2; sulfur, 13981-57-2, 7704-34-9; Antineoplastic Agents; Cytotoxins; Doxorubicin; Selenium; Sulfur Manufacturers: Teva, Hungary Funding details: BS-465/G/2018 Funding text 1: The Authors would like to thank Prof. Jadwiga Handzlik for her comprehensive discussion. The work was supported by Pedagogical University of Cracow (BS-465/G/2018). Department of Chemistry, Institute of Biology, Pedagogical University of Cracow, Podchorazych 2, Kraków, 30-084, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Faculty of Chemistry, Jagiellonian University, Kraków, Poland Cited By :5 Export Date: 18 January 2021 CODEN: ANTRD Correspondence Address: Zesławska, E.; Department of Chemistry, Institute of Biology, Pedagogical University of Cracow, Podchorazych 2, Poland; email: ewa.zeslawska@up.krakow.pl Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; selenium, 7782-49-2; sulfur, 13981-57-2, 7704-34-9; Antineoplastic Agents; Cytotoxins; Doxorubicin; Selenium; Sulfur Manufacturers: Teva, Hungary Funding details: BS-465/G/2018 Funding text 1: The Authors would like to thank Prof. Jadwiga Handzlik for her comprehensive discussion. The work was supported by Pedagogical University of Cracow (BS-465/G/2018). AB - BACKGROUND/AIM: Multidrug resistance leads to therapeutic difficulties. There is great interest in experimental chemotherapy regarding multidrug resistance inhibitors and new anticancer agents. The aim of this study was to evaluate the anticancer activity of exocyclic sulfur and selenoorganic compounds on mouse T-lymphoma cell lines. MATERIALS AND METHODS: A series of eighteen sulfur and selenium analogues of 2[1H]-pyrimidinone and hydantoin derivatives were evaluated towards their efflux modulating, cytotoxic and antiproliferative effects in mouse T-lymphoma cells. The combination assay with doxorubicin on multidrug resistant mouse T-lymphoma cells was performed in order to see the nature of drug interactions. Crystal structures were determined for two selected compounds with the highest efflux-modulating activity. RESULTS: The sulfur analogues with aromatic rings almost perpendicular to pyrimidinethione ring at positions 1 and 6 showed the highest efflux inhibitory action, while all selenium analogues showed good antiproliferative and cytotoxic activities. CONCLUSION: The sulfur analogues can be modified towards improving their efflux inhibitory activity, whereas the selenium towards antiproliferative and cytotoxic activities. LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Andrea AU - Kincses, Annamária AU - Mosolygó, Tímea AU - Ádám, Szabó Tönki AU - Carmen, Sanmartín AU - Jadwiga, Handzlik AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella TI - SELENOCOMPOUNDS AS PROMISING ANTIBACTRIAL AGENTS JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl.1. SP - 118 EP - 119 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3283956 ID - 3283956 N1 - Supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences and by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4 A/2-11-1-2012-0001 'National Excellence Program'. LA - English DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Sátori, Gréta AU - Kúsz, Norbert AU - Mosolygó, Tímea AU - Burián, Katalin AU - Hohmann, Judit AU - Rédei, Dóra AU - Spengler, Gabriella TI - Anticancer activity of diterpenes isolated from euphorbia taurinensis JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl.1. SP - 135 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3284060 ID - 3284060 N1 - Supported by the project GINOP-2.3.2-15-2016-00012. Absztraktok DOI-ja: 10.1556/030.64.2017.102 LA - English DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Spengler, Gabriella AU - Szilvia, Varga AU - Varga, Borisz AU - Csonka, Ákos AU - Shirley, Sancha AU - Silva, Mulhovo AU - Ana, Margarida Madureira AU - Maria-José, U Ferreira TI - CONSTITUENTS OF CLEISTOCHLAMYS KIRKII AS ANTIBACTERIALS AND EFFLUX PUMP INHIBITORS JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl.1. SP - 134 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3284046 ID - 3284046 N1 - Supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4 A/2-11-1-2012-0001'National Excellence Program' and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work was supported by the project GINOP-2.3.2-15-2016-00012. LA - English DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Szabó, Ágnes Míra AU - Ryosuke, Saijo AU - Genki, Watanabe AU - Masami, Kawase AU - Molnár, József AU - Spengler, Gabriella TI - Fluorinated Phosphorus Ylides as Inhibitors of Bacterial Efflux Pumps JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl.1. SP - 43 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3283415 ID - 3283415 N1 - Absztraktok DOI-ja: 10.1556/030.64.2017.101 LA - English DB - MTMT ER - TY - GEN AU - Kincses, Annamária AU - Spengler, Gabriella AU - Mosolygó, Tímea AU - Ádám, Szabó-Tönki AU - Carmen, Sanmartin AU - Jadwiga, Handzlik AU - Enrique, Dominguez-Álvarez TI - Selenocompounds as novel antibacterial agents and efflux pump inhibitors in Gram-negative bacteria PY - 2017 UR - https://m2.mtmt.hu/api/publication/3228067 ID - 3228067 LA - English DB - MTMT ER - TY - JOUR AU - Berta, Barta Holló AU - József, Magyari AU - Kincses, Annamária AU - Gajdács, Márió AU - Nové, Márta AU - Varga, Borisz AU - Csonka, Ákos AU - Spengler, Gabriella AU - Katalin, Mészáros Szécsényi TI - Antibacterial Activity of Hydrazone-Based Transition Metal Complexes JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl. 1 SP - 112 EP - 112 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3283951 ID - 3283951 N1 - This study was supported by the project GINOP-2.3.2-15-2016-00038. This study was also supported by the János Bolyai Scholarship of the Hungarian Academy of Sciences. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Borisz AU - Csonka, Ákos AU - Csonka, Andrea AU - Molnár, József AU - Leonard, Amaral AU - Spengler, Gabriella TI - Possible Biological and Clinical Applications of Phenothiazines JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 37 PY - 2017 IS - 11 SP - 5983 EP - 5993 PG - 11 SN - 0250-7005 DO - 10.21873/anticanres.12045 UR - https://m2.mtmt.hu/api/publication/3271829 ID - 3271829 N1 - This research was supported by the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, cofinanced by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. G.S. was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Travel Medicine, Institute of Hygiene and Tropical Medicine, New University of Lisbon, Lisbon, Portugal Cited By :51 Export Date: 3 June 2021 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Dóm tér 10, Hungary; email: spengler.gabriella@med.uszeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Burián, Katalin AU - Spengler, Gabriella TI - A leggyakoribb nemi betegségekre vonatkozó ismeretek középiskolai pedagógusok számára I. rész. Knowledge of the most common genital diseases for high school teachers Part I TS - Knowledge of the most common genital diseases for high school teachers Part I JF - EGÉSZSÉGFEJLESZTÉS J2 - EGÉSZSÉGFEJLESZTÉS VL - 58 PY - 2017 IS - 3 SP - 18 EP - 25 PG - 8 SN - 1786-2434 DO - 10.24365/ef.v58i3.175 UR - https://m2.mtmt.hu/api/publication/3280072 ID - 3280072 N1 - Szakbírált tanulmány Az Egészségfejlesztés 2016. évtől (LVII. évfolyamtól) kezdve csak online formában jelenik meg. A szerzők az MTA-SZTE Mikrobiológia és Egészségnevelés Szakmódszertani Kutatócsoport tagjai, akik köszönetet mondanak az MTA Tantárgy-pedagógiai Kutatási Programnak a közlemény létrejöttének támogatásáért. LA - Hungarian DB - MTMT ER - TY - CHAP AU - Kovács, Dávid AU - Igaz, Nóra AU - Annamária, Marton AU - Bélteky, Péter AU - Spengler, Gabriella AU - Csaba, Vizler AU - Bodai, László AU - Boros, Imre Miklós AU - Zoltán, Kónya AU - Csontné Kiricsi, Mónika ED - Zsuzsanna, Heiszler ED - Róbert, Hohol ED - Nóra, Éles-Etele TI - Metallic nanoparticles in the tumor microenvironment disrupt tumor-stroma crosstalk and inhibit metastasis T2 - Hungarian Molecular Life Sciences 2017 PB - Diamond Congress Kft. CY - Budapest SN - 9786155270345 PY - 2017 SP - 219 EP - 220 PG - 2 UR - https://m2.mtmt.hu/api/publication/3212796 ID - 3212796 LA - English DB - MTMT ER - TY - GEN AU - Szabó, Diána AU - Endrész, Valéria AU - Dávid, Kovács AU - Igaz, Nóra AU - Spengler, Gabriella AU - Molnár, József AU - Burián, Katalin AU - Csontné Kiricsi, Mónika AU - Rovó, László TI - 4th Congress of European ORL- HNS. Antifibrotic effect of Mitomycin-C human vocal cord fibroblast - impact on upper airway stenosis treatment TS - Antifibrotic effect of Mitomycin-C human vocal cord fibroblast - impact on upper airway stenosis treatment PY - 2017 SP - 110 EP - 110 PG - 1 UR - https://m2.mtmt.hu/api/publication/3341246 ID - 3341246 N1 - (absztrakt) LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Spengler, Gabriella AU - Zsoldiné Urbán, Edit TI - Identification and antimicrobial susceptibility testing of anaerobic bacteria: Rubik's cube of clinical microbiology? JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 6 PY - 2017 IS - 4 PG - 29 SN - 2079-6382 DO - 10.3390/antibiotics6040025 UR - https://m2.mtmt.hu/api/publication/3289256 ID - 3289256 N1 - Funding Agency and Grant Number: European Union; State of Hungary; European Social Fund [TAMOP 4.2.4.A/2-11-1-2012-0001]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; New National Excellence Program of the Ministry of Human Capacities [UNKP-17-3] Funding text: This study was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TAMOP 4.2.4.A/2-11-1-2012-0001 'National Excellence Program.' G.S. was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. M.G. was supported by the UNKP-17-3 New National Excellence Program of the Ministry of Human Capacities. M.G. has received input for the study/project through ESCMID's mentorship program by E.U. The authors would like to thank the "Top 35 of Antibiotics Travel Awards 2017" for the opportunity to publish in the Journal. AB - Anaerobic bacteria have pivotal roles in the microbiota of humans and they are significant infectious agents involved in many pathological processes, both in immunocompetent and immunocompromised individuals. Their isolation, cultivation and correct identification differs significantly from the workup of aerobic species, although the use of new technologies (e.g., matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, whole genome sequencing) changed anaerobic diagnostics dramatically. In the past, antimicrobial susceptibility of these microorganisms showed predictable patterns and empirical therapy could be safely administered but recently a steady and clear increase in the resistance for several important drugs (beta-lactams, clindamycin) has been observed worldwide. For this reason, antimicrobial susceptibility testing of anaerobic isolates for surveillance purposes or otherwise is of paramount importance but the availability of these testing methods is usually limited. In this present review, our aim was to give an overview of the methods currently available for the identification (using phenotypic characteristics, biochemical testing, gas-liquid chromatography, MALDI-TOF MS and WGS) and antimicrobial susceptibility testing (agar dilution, broth microdilution, disk diffusion, gradient tests, automated systems, phenotypic and molecular resistance detection techniques) of anaerobes, when should these methods be used and what are the recent developments in resistance patterns of anaerobic bacteria. LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Spengler, Gabriella AU - Sanmartin, C AU - Marc, MA AU - Handzlik, J AU - Dominguez-Alvarez, E TI - Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line JF - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS J2 - BIOORG MED CHEM LETT VL - 27 PY - 2017 IS - 4 SP - 797 EP - 802 PG - 6 SN - 0960-894X DO - 10.1016/j.bmcl.2017.01.033 UR - https://m2.mtmt.hu/api/publication/3179770 ID - 3179770 N1 - Megjegyzés-26430381 N1 Funding details: ESF, European Social Fund N1 Funding details: MTA, Magyar Tudományos Akadémia N1 Funding text: The authors are grateful to Mrs. Anikó Váradi Vigyikán for laboratory work and assistance; and to Prof. Dr. Juan Antonio Palop for his contribution and guidance in the design and structural characterization of the derivatives. This study was supported by the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. This paper was also supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Megjegyzés-26430390 N1 Funding details: ESF, European Social Fund N1 Funding details: MTA, Magyar Tudományos Akadémia N1 Funding text: The authors are grateful to Mrs. Anikó Váradi Vigyikán for laboratory work and assistance; and to Prof. Dr. Juan Antonio Palop for his contribution and guidance in the design and structural characterization of the derivatives. This study was supported by the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. This paper was also supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Funding Agency and Grant Number: Szeged Foundation for Cancer Research; European UnionEuropean Union (EU); State of Hungary; European Social FundEuropean Social Fund (ESF) [TAMOP 4.2.4. A/2-11-1-2012-0001]; Janos Bolyai Research Scholarship of the Hungarian Academy of SciencesHungarian Academy of Sciences Funding text: The authors are grateful to Mrs. Aniko Varadi Vigyikan for laboratory work and assistance; and to Prof. Dr. Juan Antonio Palop for his contribution and guidance in the design and structural characterization of the derivatives. This study was supported by the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TAMOP 4.2.4. A/2-11-1-2012-0001 'National Excellence Program'. This paper was also supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Department of Organic and Pharmaceutical Chemistry, School of Pharmacy, University of Navarra, Irunlarrea 1, Pamplona, 31010, Spain Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Cited By :23 Export Date: 31 July 2020 CODEN: BMCLE Correspondence Address: Domínguez-Álvarez, E.; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Poland; email: enriquedominguezalv@gmail.com Chemicals/CAS: dimethyl sulfoxide, 67-68-5; verapamil, 152-11-4, 52-53-9; multidrug resistance protein, 149200-37-3, 208997-77-7; ABCB1 protein, human; Anhydrides; Antineoplastic Agents; Esters; Organoselenium Compounds; P-Glycoproteins; Verapamil Funding details: European Social Fund, ESF, A/2-11-1-2012-0001 Funding details: European Commission, EC Funding details: Magyar Tudományos Akadémia, MTA Funding text 1: The authors are grateful to Mrs. Anik? V?radi Vigyik?n for laboratory work and assistance; and to Prof. Dr. Juan Antonio Palop for his contribution and guidance in the design and structural characterization of the derivatives. This study was supported by the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of T?MOP 4.2.4. A/2-11-1-2012-0001 ?National Excellence Program?. This paper was also supported by the J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences. Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Department of Organic and Pharmaceutical Chemistry, School of Pharmacy, University of Navarra, Irunlarrea 1, Pamplona, 31010, Spain Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Cited By :30 Export Date: 18 January 2021 CODEN: BMCLE Correspondence Address: Domínguez-Álvarez, E.; Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Poland; email: enriquedominguezalv@gmail.com Chemicals/CAS: dimethyl sulfoxide, 67-68-5; verapamil, 152-11-4, 52-53-9; multidrug resistance protein, 149200-37-3, 208997-77-7; ABCB1 protein, human; Anhydrides; Antineoplastic Agents; Esters; Organoselenium Compounds; P-Glycoproteins; Verapamil Funding details: European Social Fund, ESF, A/2-11-1-2012-0001 Funding details: Magyar Tudományos Akadémia, MTA Funding details: European Commission, EC Funding text 1: The authors are grateful to Mrs. Anik? V?radi Vigyik?n for laboratory work and assistance; and to Prof. Dr. Juan Antonio Palop for his contribution and guidance in the design and structural characterization of the derivatives. This study was supported by the Szeged Foundation for Cancer Research, the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of T?MOP 4.2.4. A/2-11-1-2012-0001 ?National Excellence Program?. This paper was also supported by the J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences. AB - Taking into account that multidrug resistance (MDR) is the main cause for chemotherapeutic failure in cancer treatment and as a continuation of our efforts to overcome this problem we report the evaluation of one cyclic selenoanhydride (1) and ten selenoesters (2-11) in MDR human colon adenocarcinoma Colo 320 cell line. The most potent derivatives (1, 9-11) inhibited the ABCB1 efflux pump much stronger than the reference compound verapamil. Particularly, the best one (9) was 4-fold more potent than verapamil at a 10-fold lower concentration. Furthermore, the evaluated derivatives exerted a potent and selective cytotoxic activity. In addition, they were strong apoptosis inducers as the four derivatives triggered apoptotic events in a 64-72% of the examined MDR Colo 320 human adenocarcinoma cells. LA - English DB - MTMT ER - TY - CHAP AU - Gajdács, Márió AU - Handzlik, Jadwiga AU - Sanmartín, Carmen AU - Domínguez-Álvarez, Enrique AU - Spengler, Gabriella ED - Bódog, Ferenc ED - Csiszár, Beáta ED - Hegyi, Dávid ED - Pónusz, Róbert TI - Rákellenes hatású szelenoészterek a kombinációs kemoterápiában T2 - DKK17-Doktoranduszok a Klinikai Kutatásokban absztraktkötet PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs SN - 9789634291602 PY - 2017 SP - 45 EP - 45 PG - 1 UR - https://m2.mtmt.hu/api/publication/3285973 ID - 3285973 N1 - A kutatás az Emberi Erőforrások Minisztériuma UNKP-17-3 kódszámú Új Nemzeti Kiválóság Programjának támogatásával készült. Spengler Gabriellát a Bolyai János Kutatási Ösztöndíj támogatta. LA - Hungarian DB - MTMT ER - TY - CHAP AU - Gajdács, Márió AU - Jadwiga, Handzlik AU - Carmen, Sanmartín AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella TI - Selenocompounds as combinational agents in cancer chemotherapy: An in vitro perspective T2 - 19th DKMT Euroregional Conference on Environment and Health PB - University of Szeged, Faculty of Medicine CY - Szeged SN - 9789633065358 PY - 2017 SP - 40 EP - 40 PG - 1 UR - https://m2.mtmt.hu/api/publication/3237695 ID - 3237695 LA - English DB - MTMT ER - TY - CHAP AU - Gajdács, Márió AU - Domínguez-Álvarez, Enrique AU - Handzlik, Jadwiga AU - Spengler, Gabriella ED - Keresztes, Gábor ED - Kohus, Zsolt ED - Szabó, Katalin ED - Tokody, Dániel TI - Szelenoanhidrid és szelenoészter típusú vegyületek multidrog rezisztencia visszafordító hatása vastagbél adenokarcinóma sejteken T2 - Tavaszi Szél 2017 Konferencia. Nemzetközi Multidiszciplináris Konferencia PB - Doktoranduszok Országos Szövetsége (DOSZ) CY - Budapest SN - 9786155586149 PY - 2017 SP - 365 EP - 366 PG - 2 UR - https://m2.mtmt.hu/api/publication/3207896 ID - 3207896 LA - Hungarian DB - MTMT ER - TY - CONF AU - Jelena, M. Poljarevic AU - May, Nóra Veronika AU - Spengler, Gabriella AU - Dömötör, Orsolya AU - Milica, Orlovic AU - Aleksandar, R. Savic AU - Sanja, Grguric-Sipka AU - Éva, A. Enyedy TI - Synthesis, solution equilibria and antitumor activity of Ru(II)(η6-toluene) complexes of various picolinates T2 - 14th International Conference on Applied Bioinorganic Chemistry PY - 2017 SP - 245 EP - 245 PG - 1 UR - https://m2.mtmt.hu/api/publication/3239469 ID - 3239469 N1 - Acknowledgement: OTKA PD103905,GINOP-2.3.2-15-2016-00038, MPNTR 172035 and MPNTR postdoctoral grant (J. M. P.), J. Bolyai Research Scholarship (E. A. E.) LA - English DB - MTMT ER - TY - CHAP AU - Kincses, Annamária AU - Spengler, Gabriella AU - Szabó, Tönki Ádám AU - Domínguez-Álvarez, Enrique ED - Bódog, Ferenc ED - Csiszár, Beáta ED - Hegyi, Dávid ED - Pónusz, Róbert TI - Szelénvegyületek biológiai hatásának vizsgálata baktérium modelleken T2 - DKK17-Doktoranduszok a Klinikai Kutatásokban absztraktkötet PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs SN - 9789634291602 PY - 2017 SP - 61 EP - 61 PG - 1 UR - https://m2.mtmt.hu/api/publication/3287447 ID - 3287447 N1 - A kutatás az Emberi Erőforrások Minisztériuma UNKP-17-3 kódszámú Új Nemzeti Kiválóság Programjának támogatásával (Kincses Annamária), illetve a Bolyai János Kutatási Ösztöndíj támogatásával készült (Dr. Spengler Gabriella). LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kúsz, Norbert AU - Sátori, Gréta AU - Kincses, Annamária AU - Spengler, Gabriella AU - Barina, Zoltán AU - Hohmann, Judit AU - Rédei, Dóra TI - Novel MDR-modulating Diterpenes from Euphorbia taurinensis JF - PLANTA MEDICA INTERNATIONAL OPEN J2 - PLANTA MEDICA INT OPEN VL - 4 PY - 2017 IS - S 01 SN - 2509-6656 DO - 10.1055/s-0037-1608146 UR - https://m2.mtmt.hu/api/publication/3287853 ID - 3287853 LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Mosolygó, Tímea AU - Zsoldiné Urbán, Edit AU - Carmen, Sanmartín AU - Jadwiga, Handzlik AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella TI - Selenoester Derivatives as Novel Antifungal and Antiviral Agents JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl.1 SP - 122 EP - 123 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3284004 ID - 3284004 LA - English DB - MTMT ER - TY - CHAP AU - Gajdács, Márió AU - Mosolygó, Tímea AU - Zsoldiné Urbán, Edit AU - Dorota, Łażewska AU - Jadwiga, Handzlik AU - Katarzyna, Kieć-Kononowicz AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella ED - Ádám, Anna Adél ED - Timár, Zita ED - Ziegenheim, Szilveszter TI - In vitro and in silico assessment of urea/thiourea derivatives in antimicrobial therapy T2 - XL Kémiai Előadói Napok PB - MTA Szegedi Akadémiai Bizottság CY - Szeged SN - 9789639970830 PY - 2017 SP - 116 EP - 118 PG - 3 UR - https://m2.mtmt.hu/api/publication/3280164 ID - 3280164 LA - English DB - MTMT ER - TY - CHAP AU - Gajdács, Márió AU - Zsanett, Szabó AU - Dorota, Łażewska AU - Jadwiga, Handzlik AU - Katarzyna, Kieć-Kononowicz AU - Enrique, Domínguez-Álvarez AU - Spengler, Gabriella ED - Ádám, Anna Adél ED - Timár, Zita ED - Ziegenheim, Szilveszter TI - Evaluation of urea/thiourea derivatives as adjuvants in cancer chemotherapy T2 - XL Kémiai Előadói Napok PB - MTA Szegedi Akadémiai Bizottság CY - Szeged SN - 9789639970830 PY - 2017 SP - 113 EP - 115 PG - 3 UR - https://m2.mtmt.hu/api/publication/3280162 ID - 3280162 LA - English DB - MTMT ER - TY - CONF AU - Gajdács, Márió AU - Spengler, Gabriella AU - Markó-Kucsera, Mária AU - Szabó, Andrea AU - Paulik, Edit TI - The attitude of healthcare professionals towards antibiotic resistance T2 - 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) PB - European Society of Clinical Microbiology and Infectious Diseases (ESCMID) C1 - Vienna PY - 2017 PG - 2 UR - https://m2.mtmt.hu/api/publication/3215185 ID - 3215185 LA - English DB - MTMT ER - TY - JOUR AU - Nové, Márta AU - Kincses, Annamária AU - Orsolya, Vásárhelyi AU - Vivien, Unger AU - Viktor, Tóth AU - Molnár, József AU - Leonard, Amaral AU - Spengler, Gabriella TI - THE ROLE OF EFFLUX PUMPS AND ENVIRONMENTAL pH IN BACTERIAL MULTIDRUG RESISTANCE JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl.1. SP - 155 EP - 156 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3284117 ID - 3284117 N1 - Supported by European Union and the State of Hungary, co-financed by the European Social Fund in the framework TÁMOP-4.2.4. A/2-11-1-2012-001 'National Excellence Program' and the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. Absztraktok DOI-ja: 10.1556/030.64.2017.102 LA - English DB - MTMT ER - TY - JOUR AU - Paterna, A AU - Kincses, Annamária AU - Spengler, Gabriella AU - Mulhovo, S AU - Molnár, József AU - Ferreira, Maria-Jose U. TI - Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 128 PY - 2017 SP - 247 EP - 257 PG - 11 SN - 0223-5234 DO - 10.1016/j.ejmech.2017.01.044 UR - https://m2.mtmt.hu/api/publication/3183602 ID - 3183602 N1 - Acknowledgements This study was financially supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal (projects: PTDC/QEQ-MED/0905/2012; Pest-OE/SAU/UI4013/2014; PhD grant (SFRH/BD/77612/2011) and by the GINOP-2.3.2-15-2016-00012 project (University of Szeged, Hungary). The authors thank the Portuguese Embassy in Mozambique, as well as the Portuguese Office of International Affairs for plant transport. We also acknowledge Prof. Carlos Cordeiro, Faculdade de Ciências, Universidade de Lisboa, for high resolution mass data (FCT, REDE/1501/REM/2005). AB - Dregamine (1) and tabernaemontanine (2), two epimeric monoterpene indole alkaloids isolated in large amount from the roots of the African plant Tabernaemontana elegans, were derivatized, yielding ten imine derivatives, as previously described (3-12). In the present study, aiming at increasing the pool of analogues for establishing structure-activity relationships (SAR), compounds 1 and 2 were further submitted to several chemical transformations, yielding thirteen new derivatives (13-25). Their structures were assigned by spectroscopic methods, including 1D and 2D NMR experiments. Compounds 1-25 were evaluated for their effects on the reversion of multidrug resistance (MDR) in cancer cells mediated by P-glycoprotein (P-gp/ABCB1), through combination of functional and chemosensitivity assays, using a human ABCB1-transfected mouse T-lymphoma cell model. SAR analysis showed that different substituents at C-3 and at the indole nitrogen led to different ABCB1 modulatory effects. When compared to the parent compounds, a remarkable enhancement in MDR reversal activity was found for derivatives sharing a new aromatic moiety. Thus, the strongest ability as MDR reversers, and a manifold activity when compared to verapamil, was found for compound 8, the epimeric compounds 9 and 10, and compound 15, bearing pyrazine, bromo-pyridine, and methoxybenzyloxycarbonyl moieties, respectively. In drug combination assays, all compounds tested were revealed to interact synergistically with doxorubicin. Collectively, the results indicate that some of these derivatives may be promising leads for overcoming MDR in cancer. LA - English DB - MTMT ER - TY - JOUR AU - Reis, MA AU - Ahmed, OB AU - Spengler, Gabriella AU - Molnár, József AU - Lage, H AU - Ferreira, MU TI - Exploring Jolkinol D Derivatives To Overcome Multidrug Resistance in Cancer JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 80 PY - 2017 IS - 5 SP - 1411 EP - 1420 PG - 10 SN - 0163-3864 DO - 10.1021/acs.jnatprod.6b01084 UR - https://m2.mtmt.hu/api/publication/3227556 ID - 3227556 N1 - This study was financially supported by Fundacao para a Ciencia e a Tecnologia (FCT), Portugal (project PTDC/QEQ: MED/0905/2012; PhD grant SFRH/BD/72915/2010), German Egyptian Research Long-term Scholarship (GERLS) Program 2014 (57076387) provided by the German Academic Exchange Service (DAAD), and the contribution of the Foundation for Cancer Research Szeged, Hungary. We also acknowledge Carlos Cordeiro, Faculdade de Ciencias, Universidade de Lisboa, for HRMS data (FCT, REDE/1501/REM/2005). AB - Macrocyclic monoacyl lathyrane derivatives bearing a benzoyl moiety were previously found to be strong ABCB1 modulators. To explore the effects of different substituents of the aromatic moiety, 14 new compounds (1.1-1.7, 1.10, and 2.1-2.4) were prepared from jolkinol D (1), obtained from Euphorbia piscatoria, and from jolkinodiol (2), its hydrolysis derivative. Compounds 1.8 and 1.9, having aliphatic moieties, were also obtained. The reversal of ABCB1-mediated MDR was evaluated through functional and chemosensitivity assays on the human ABCB1-gene-transfected L5178Y mouse T-lymphoma cell line. Structure-activity relationships showed that addition of electron-donating groups to the aromatic moiety improved the activity. The effects on the ATPase activity of the strongest modulator (1.3) and the inactive jolkinol D (1) were also investigated and compared. Moreover, in the chemosensitivity assay, most of the compounds interacted synergistically with doxorubicin. Compounds 1.1-1.10 and 2.1-2.4 were further assessed for their collateral sensitivity effect against the human cancer cells: EPG85-257 (gastric) and EPP85-181 (pancreatic), and the matching drug-selected cells EPG85-257RDB, EPG85-257RNOV, EPP85-181RDB, and EPP85-181RNOV. The most promising ones (1.8 and 1.10) along with compound 3, previously selected, were investigated as apoptosis inducers. The compounds were able to induce apoptosis through caspase-3 activation, with significant differences being observed between the parental and resistant cells. LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Kincses, Annamária AU - Gajdács, Márió AU - Amaral, L TI - New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria JF - MOLECULES J2 - MOLECULES VL - 22 PY - 2017 IS - 3 PG - 25 SN - 1420-3049 DO - 10.3390/molecules22030468 UR - https://m2.mtmt.hu/api/publication/3201553 ID - 3201553 N1 - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, 6720, Hungary Travel Medicine, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, 1349-008, Portugal Cited By :77 Export Date: 3 June 2021 CODEN: MOLEF Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Hungary; email: spengler.gabriella@med.u-szeged.hu AB - Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials. This inappropriate application and mismanagement of antibiotics have led to serious problems in the therapy of infectious diseases. Bacteria can develop resistance by various mechanisms and one of the most important factors resulting in MDR is efflux pump-mediated resistance. Because of the importance of the efflux-related multidrug resistance the development of new therapeutic approaches aiming to inhibit bacterial efflux pumps is a promising way to combat bacteria having over-expressed MDR efflux systems. The definition of an efflux pump inhibitor (EPI) includes the ability to render the bacterium increasingly more sensitive to a given antibiotic or even reverse the multidrug resistant phenotype. In the recent years numerous EPIs have been developed, although so far their clinical application has not yet been achieved due to their in vivo toxicity and side effects. In this review, we aim to give a short overview of efflux mediated resistance in bacteria, EPI compounds of plant and synthetic origin, and the possible methods to investigate and screen EPI compounds in bacterial systems. LA - English DB - MTMT ER - TY - CONF AU - Gonda, Tímea AU - Spengler, Gabriella AU - Kincses, Annamária AU - Csorba, Attila AU - Kúsz, Norbert AU - Hunyadi, Attila TI - Synthesis and biological activity of oxidized chalcone derivatives T2 - COST ACTION CM1407 4th Meeting PY - 2017 UR - https://m2.mtmt.hu/api/publication/3287590 ID - 3287590 LA - English DB - MTMT ER - TY - JOUR AU - Mosolygó, Tímea AU - Yunsu, Jang AU - Muhammad, Jawad Nasim AU - Kincses, Annamária AU - Spengler, Gabriella AU - Burián, Katalin AU - Jadwiga, Handzlik AU - Claus, Jacob TI - Antibacterial effect of arylmethyl selenocyanates with various aromatic moieties JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 64 PY - 2017 IS - Suppl.1. SP - 148 EP - 149 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3284103 ID - 3284103 N1 - Supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 'National Excellence Program' and the János Bolyai Research Scholarhip of the Hungarian Academy of Sciences. Absztraktok DOI-ja: 10.1556/030.64.2017.102 LA - English DB - MTMT ER - TY - JOUR AU - Aliona, Dobrova AU - Sonja, Platzer AU - Felix, Bacher AU - Miljan, N M Milunovic AU - Anatolie, Dobrov AU - Spengler, Gabriella AU - Enyedy, Éva Anna AU - Ghenadie, Novitchi AU - Vladimir, B Arion TI - Structure-antiproliferative activity studies on L-proline- and homoproline-4-N-pyrrolidine-3-thiosemicarbazone hybrids and their nickel(II), palladium(II) and copper(II) complexes JF - JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS J2 - J CHEM SOC DALTON TRANS VL - 45 PY - 2016 IS - 34 SP - 13427 EP - 13439 PG - 13 SN - 1472-7773 DO - 10.1039/C6DT02784A UR - https://m2.mtmt.hu/api/publication/3096947 ID - 3096947 N1 - University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, Vienna, A-1090, Austria Department of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Department of Inorganic and Analytical Chemistry, University of Szeged, Dóm tér 7, Szeged, H-6720, Hungary Laboratoire National, Champs Magnetiques Intenses-CNRS, 25 Avenue des Martyrs, Grenoble Cedex 9, 38042, France Cited By :44 Export Date: 23 September 2023 CODEN: DTARA Correspondence Address: Arion, V.B.; University of Vienna, Währinger Strasse 42, Austria; email: vladimir.arion@univie.ac.at Funding details: Austrian Science Fund, FWF, P28223-N34 Funding details: Universität Wien Funding text 1: We are indebted to the Austrian Science Fund (FWF) for the financial support of the project P28223-N34. We also thank Maria S. Novak and Dr Michael Jakupec for performing the antiproliferative activity assays in human cancer cell lines, Alexander Roller from the X-ray diffraction centre of the Faculty of Chemistry of the University of Vienna and Dr Jozef Kozisek from Slovak Technical University for the collection of X-ray data, and Prof. Markus Galanski for recording the NMR spectra. LA - English DB - MTMT ER - TY - JOUR AU - Amaral, L AU - Spengler, Gabriella AU - Molnár, József TI - Identification of Important Compounds Isolated from Natural Sources that Have Activity Against Multidrug-resistant Cancer Cell Lines: Effects on Proliferation, Apoptotic Mechanism and the Efflux Pump Responsible for Multi-resistance Phenotype JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 36 PY - 2016 IS - 11 SP - 5665 EP - 5672 PG - 8 SN - 0250-7005 DO - 10.21873/anticanres.11149 UR - https://m2.mtmt.hu/api/publication/3135013 ID - 3135013 N1 - Megjegyzés-26262757 SI 10.21873/anticanres.11149 AB - The focus of this mini-review is to identify non-toxic compounds isolated from natural sources (plants) that exhibit specific activity against efflux pumps of specific multidrug-resistant (MDR) cancer cell lines, inhibit proliferation of the MDR cancer cell lines and inhibit the activity of overexpressed efflux pumps of the MDR cancer cell line. LA - English DB - MTMT ER - TY - CONF AU - Kincses, Annamária AU - Ádám, Szabó Tönki AU - Marion, Szatmári AU - Mosolygó, Tímea AU - Enrique, Domínguez-Álvarez AU - Carmen, Sanmartín AU - Jadwiga, Handzlik AU - Spengler, Gabriella TI - Efflux pump inhibiting properties of selenocompounds in bacteria T2 - The meeting of "Bio-Selenium People in Europe" PY - 2016 UR - https://m2.mtmt.hu/api/publication/3114913 ID - 3114913 LA - English DB - MTMT ER - TY - CHAP AU - Armada, A AU - Martins, C AU - Spengler, Gabriella AU - Molnár, József AU - Amaral, L AU - Rodrigues, AS AU - Viveiros, M ED - Rueff, José ED - Rodrigues, Sebastião António TI - Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter T2 - Cancer Drug Resistance PB - Springer New York CY - New York, New York SN - 9781493933457 T3 - Methods in Molecular Biology, ISSN 1064-3745 ; 1395. PY - 2016 SP - 87 EP - 103 PG - 17 DO - 10.1007/978-1-4939-3347-1_7 UR - https://m2.mtmt.hu/api/publication/3026841 ID - 3026841 AB - The cell membrane P-glycoprotein (P-gp; MDR1, ABCB1) is an energy-dependent efflux pump that belongs to the ATP-binding cassette (ABC) family of transporters, and has been associated with drug resistance in eukaryotic cells. Multidrug resistance (MDR) is related to an increased expression and function of the ABCB1 (P-gp) efflux pump that often causes chemotherapeutic failure in cancer. Modulators of this efflux pump, such as the calcium channel blocker verapamil (VP) and cyclosporine A (CypA), can reverse the MDR phenotype but in vivo studies have revealed disappointing results due to adverse side effects. Currently available methods are unable to visualize and assess in a real-time basis the effectiveness of ABCB1 inhibitors on the uptake and efflux of ABCB1 substrates. However, predicting and testing ABCB1 modulation activity using living cells during drug development are crucial. The use of ABCB1-transfected mouse T-lymphoma cell line to study the uptake/efflux of fluorescent probes like ethidium bromide (EB), rhodamine 123 (Rh-123), and carbocyanine dye DiOC2, in the presence and absence of potential inhibitors, is currently used in our laboratories to evaluate the ability of a drug to inhibit ABCB1-mediated drug accumulation and efflux. Here we describe and compare three in vitro methods, which evaluate the permeability, transport kinetics of fluorescent substrates, and inhibition of the ABCB1 efflux pump by drugs of chemical synthesis or extracted from natural sources, using model cancer cell lines overexpressing this transporter, namely (1) real-time fluorimetry that assesses the accumulation of ethidium bromide, (2) flow cytometry, and (3) fluorescent microscopy using rhodamine 123 and DiOC2. LA - English DB - MTMT ER - TY - JOUR AU - Barta, Holló B AU - Magyari, József AU - Armaković, S AU - Bogdanović, GA AU - Rodić, MV AU - Armaković, SJ AU - Molnár, József AU - Spengler, Gabriella AU - Leovac, VM AU - Meszaros, Szecsenyi K TI - Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): Synthesis, characterization, reactivity assessment and biological evaluation JF - NEW JOURNAL OF CHEMISTRY J2 - NEW J CHEM VL - 40 PY - 2016 IS - 7 SP - 5885 EP - 5895 PG - 11 SN - 1144-0546 DO - 10.1039/c6nj00560h UR - https://m2.mtmt.hu/api/publication/3102607 ID - 3102607 AB - A new hydrazone-type ligand with a five N-donor set and its coordination compounds with Co(iii), Ni(ii), Cu(ii) and Zn(ii) metal centres were synthesized. The crystal and molecular structure of the Co(iii) complex was determined by X-ray structural analysis. All the compounds were characterized by elemental analysis, molar conductivity and FT-IR spectral data. The cobalt(iii) compound is a neutral binuclear complex formed by coordination of two, doubly deprotonated ligand anions as bridges between the Co(iii) centres. The metal centres are additionally connected by a peroxido bridge, which was observed for the first time in Co(iii) complexes with similar ligands. The other coordination compounds are mononuclear complexes wherein only one doubly deprotonated ligand is coordinated to the central ion in a tetradentate fashion. The structures were theoretically investigated employing density functional theory (DFT) calculations with B3LYP exchange-correlation functional and LACV3P+(d,p) basis sets for the coordination compounds and 6-31+G(d,p) basis set for the ligand. Molecular electrostatic potential (MEP) and average local ionization energy (ALIE) surfaces were calculated to study the reactive properties of the compounds. The thermal behaviour of the compounds was determined by simultaneous thermogravimetric-differential scanning calorimetric (TG-DSC) measurements and the results were correlated to the proposed structures and to calculated MEP/ALIE surfaces. The compounds were tested in vitro for antiproliferative effects on parental (L5178Y) mouse T-cell lymphoma cells, on L5178Y transfected with pHa ABCB1/A retrovirus and for reversal of multidrug resistance (MDR) in tumor cells by flow cytometry. The preliminary measurements showed that the cobalt(iii) compound was an effective inhibitor of the ABC transporter PGP drug efflux pump. The ligand was somewhat less effective, the zinc complex had a moderate inhibition activity, whereas the nickel(ii) and copper(ii) compounds were inactive. © 2016 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. LA - English DB - MTMT ER - TY - JOUR AU - Domínguez-Álvarez, E AU - Gajdács, Márió AU - Spengler, Gabriella AU - Palop, JA AU - Marć, MA AU - Kieć-Kononowicz, K AU - Amaral, L AU - Molnár, József AU - Jacob, C AU - Handzlik, J AU - Sanmartín, C TI - Identification of selenocompounds with promising properties to reverse cancer multidrug resistance JF - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS J2 - BIOORG MED CHEM LETT VL - 26 PY - 2016 IS - 12 SP - 2821 EP - 2824 PG - 4 SN - 0960-894X DO - 10.1016/j.bmcl.2016.04.064 UR - https://m2.mtmt.hu/api/publication/3076161 ID - 3076161 N1 - Department of Organic and Pharmaceutical Chemistry, School of Pharmacy, University of Navarra, Irunlarrea 1, Pamplona, 31010, Spain Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College, Medyczna 9, Kraków, 30-688, Poland Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, 6720, Hungary Division of Bioorganic Chemistry, Saarland State University, Campus, Geb. B2.1, Saarbruecken, 66123, Germany Cited By :19 Export Date: 22 August 2019 CODEN: BMCLE Correspondence Address: Domínguez-Álvarez, E.; Department of Organic and Pharmaceutical Chemistry, School of Pharmacy, University of Navarra, Irunlarrea 1, Spain Chemicals/CAS: dimethyl sulfoxide, 67-68-5; thioridazine, 130-61-0, 50-52-2; verapamil, 152-11-4, 52-53-9 Funding details: European Social Fund, ESF Funding details: Magyar Tudományos Akadémia, MTA, Hungary Funding text 1: Authors would like to thank Mrs. Anikó Váradi Vigyikán for the laboratory assistance. This research was supported by the Szeged Foundation for Cancer Research , the European Union and the State of Hungary , co-financed by the European Social Fund in the framework of TÁMOP 4.2.4. A/2-11-1-2012-0001 ‘National Excellence Program’. This Letter was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (Hungary). AB - In previous studies, 56 novel selenoesters and one cyclic selenoanhydride with chemopreventive, antiproliferative and cytotoxic activity were described. Herein, the selenoanhydride and selected selenoesters were evaluated for their ability to reverse the cancer multidrug resistance (MDR) using the ABCB1 efflux pump inhibition assay in mouse MDR T-lymphoma cells. Results showed that the selenoanhydride (1) and the selenoesters with ketone terminal fragments (9-11) exerted (1.7-3.6)-fold stronger efflux pump inhibitory action than the reference verapamil. In addition, those four derivatives triggered apoptotic events in more than 80% of the examined MDR mouse cells. © 2016 Elsevier Ltd. LA - English DB - MTMT ER - TY - CONF AU - Enrique, Dominguez-Álvarez AU - Gajdács, Márió AU - Celia, Prior AU - Juan, Antonio Palop AU - Daniel, Plano AU - Carmen, Sanmartín AU - Karolina, Witek AU - Malgorzata, Anna Marc AU - Gniewormir, Latacz AU - Katarzyna, Kiec-Kononowicz AU - Jadwiga, Handzlik AU - Claus, Jacob AU - Spengler, Gabriella TI - An overview of the different biological activities shown by selenoesters and selenoanhydrides T2 - The meeting of "Bio-Selenium People in Europe" PY - 2016 UR - https://m2.mtmt.hu/api/publication/3114911 ID - 3114911 LA - English DB - MTMT ER - TY - CHAP AU - Gajdács, Márió AU - Enrique, Domínguez-Álvarez AU - Jadwiga, Handzlik AU - Spengler, Gabriella ED - Bohner, Bíborka ED - Ádám, A ED - Timár, Z ED - Ziegenheim, Sz TI - Redox-aktív szerves szelénvegyületek antitumor hatásának vizsgálata T2 - XXXIX Kémiai Előadói Napok PB - MTA Szegedi Akadémiai Bizottság CY - Szeged SN - 9789639970731 PY - 2016 SP - 100 EP - 101 PG - 2 UR - https://m2.mtmt.hu/api/publication/3127394 ID - 3127394 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Kincses, Annamária AU - Szabó, Ágnes Míra AU - Saijo, R AU - Watanabe, G AU - Kawase, M AU - Molnár, József AU - Spengler, Gabriella TI - Fluorinated Beta-diketo Phosphorus Ylides Are Novel Efflux Pump Inhibitors in Bacteria JF - IN VIVO J2 - IN VIVO VL - 30 PY - 2016 IS - 6 SP - 813 EP - 817 PG - 5 SN - 0258-851X DO - 10.21873/invivo.10999 UR - https://m2.mtmt.hu/api/publication/3135011 ID - 3135011 AB - BACKGROUND: One of the most important resistance mechanisms in bacteria is the increased expression of multidrug efflux pumps. To combat efflux-related resistance, the development of new efflux pump inhibitors is essential. MATERIALS AND METHODS: Ten phosphorus ylides were compared based on their MDR-reverting activity in multidrug efflux pump system consisting of the subunits acridine-resistance proteins A and B (AcrA and AcrB) and the multidrug efflux pump outer membrane factor TolC (TolC) of Escherichia coli K-12 AG100 strain and its AcrAB-TolC-deleted strain. Efflux inhibition was assessed by real-time fluorimetry and the inhibition of quorum sensing (QS) was also investigated. The relative gene expression of efflux QS genes was determined by real-time reverse transcriptase quantitative polymerase chain reaction. RESULTS: The most potent derivative was Ph3P=C(COC2F5)CHO and its effect was more pronounced on the AcrAB-TolC-expressing E. coli strain, furthermore the most active compounds, Ph3P=C(COCF3)OMe, Ph3P=C(COC2F5)CHO and Ph3P=C(COCF3)COMe, reduced the expression of efflux pump and QS genes. CONCLUSION: Phosphorus ylides might be valuable EPI compounds to reverse efflux related MDR in bacteria. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Dávid AU - Szőke, Krisztina AU - Igaz, Nóra AU - Spengler, Gabriella AU - Molnár, József AU - Tóth, Tímea AU - Madarász, Dániel AU - Rázga, Zsolt AU - Kónya, Zoltán AU - Boros, Imre Miklós AU - Csontné Kiricsi, Mónika TI - Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer JF - NANOMEDICINE: NANOTECHNOLOGY BIOLOGY AND MEDICINE J2 - NANOMED: NANOTECHNOL VL - 12 PY - 2016 IS - 3 SP - 601 EP - 610 PG - 10 SN - 1549-9634 DO - 10.1016/j.nano.2015.10.015 UR - https://m2.mtmt.hu/api/publication/2990683 ID - 2990683 AB - Abstract The emergence of multidrug resistant (MDR) cancer phenotypes dramatically attenuates the efficiency of antineoplastic drug treatments often leading to the failure of chemotherapy. Therefore there is an urgent need to engineer new therapeutically useful agents and propose innovative approaches able to defeat resistant cancer cells. Although the remarkable anti-cancer features of silver nanoparticles (AgNPs) have already been delineated their impact on MDR cancer has never been investigated. Herein, we report that AgNPs have a notable anti-proliferative effect and induce apoptosis mediated cell death both in drug sensitive and in MDR cancer cells. Furthermore we show evidence that AgNPs exert an inhibitory action on the efflux activity of MDR cancer cells which feature could be exploited to enhance drug accumulation. We verified synergistic interactions of AgNPs with six different antineoplastic agents on drug resistant cells which emphasizes the excellent potential of AgNPs as combinational partners in the chemotherapy of MDR cancer. LA - English DB - MTMT ER - TY - CONF AU - Gajdács, Márió AU - Enrique, Domínguez-Álvarez AU - Jadwiga, Handzlik AU - Carmen, Sanmartín AU - Spengler, Gabriella TI - Evaluation of selenoester derivatives with potential efflux pump inhibiting and apoptosis inducing properties on cancer cells T2 - The meeting of "Bio-Selenium People in Europe" PY - 2016 PG - 1 UR - https://m2.mtmt.hu/api/publication/3114912 ID - 3114912 LA - English DB - MTMT ER - TY - JOUR AU - Reis, MA AU - Ahmed, OB AU - Spengler, Gabriella AU - Molnár, József AU - Lage, H AU - Ferreira, M-JU TI - Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction JF - PHYTOMEDICINE: INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY J2 - PHYTOMEDICINE VL - 23 PY - 2016 IS - 9 SP - 968 EP - 978 PG - 11 SN - 0944-7113 DO - 10.1016/j.phymed.2016.05.007 UR - https://m2.mtmt.hu/api/publication/3102606 ID - 3102606 AB - Background Modulation of P-glycoprotein (ABCB1) and evaluation of the collateral sensitivity effect are among the most promising approaches to overcome multidrug resistance (MDR) in cancer. In a previous study, two rare 12,17-cyclojatrophanes (1-2) and other novel jatrophanes (3-4), isolated from Euphorbia welwitschii, were screened for collateral sensitivity effect. Herein, the isolation of another jatrophane (5) is presented, being the broader goal of this work to investigate the role of euphowelwitschines A (1) and B (2), welwitschene (3), epoxywelwitschene (4) and esulatin M (5) as ABCB1 modulators and/or collateral sensitivity agents. Methods Compounds 1-5 were evaluated for ABCB1 modulation ability through combination of transport and chemosensitivity assays, using a mouse T-lymphoma MDR1-transfected cell model. Moreover, the nature of interaction of compound 4 with ABCB1 was studied, using an ATPase assay. The MDR-selective antiproliferative activity of compound 5 was evaluated against gastric (EPG85-257) and pancreatic (EPP85-181) human cancer cells and their drug-selected counterparts (EPG85-257RDB, EPG85-257RNOV, EPP85-181RDB, EPP85-181RNOV). The drug induced cell death was investigated for compounds 4 and 5, using the annexin V/PI staining and the active caspase-3 assay. Results The jatrophanes 1-5 were able to modulate the efflux activity of ABCB1, and at 2 μM, 3-5 maintained the strong modulator profile. Structure activity results indicated that high conformational flexibility of the twelve-membered ring of compounds 3-5 favored ABCB1 modulation, in contrast to the tetracyclic scaffold of compounds 1 and 2. The effects of epoxywelwitschene (4) on the ATPase activity of ABCB1 showed it to interact with the transporter and to be able to reduce the transport of a second subtrate. Drug combination experiments also corroborated the anti-MDR potential of these diterpenes due to their synergistic interaction with doxorubicin (combination index < 0.7). Esulatin M (5) showed a strong MDR-selective antiproliferative activity against EPG85-257RDB and EPP85-181RDB cells, with IC50 of 1.8 and 4.8 μM, respectively. Compounds 4 and 5 induced apoptosis via caspase-3 activation. A significant discrimination was observed between the resistant cell lines and parental cells. Conclusions This study strengthens the role of jatrophane diterpenes as lead candidates for the development of MDR reversal agents, higlighting the action of compounds 4 and 5. © 2016 Elsevier GmbH. LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Csonka, Ákos AU - Molnár, József AU - Amaral, L TI - The Anticancer Activity of the Old Neuroleptic Phenothiazine-type Drug Thioridazine JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 36 PY - 2016 IS - 11 SP - 5701 EP - 5706 PG - 6 SN - 0250-7005 DO - 10.21873/anticanres.11153 UR - https://m2.mtmt.hu/api/publication/3135012 ID - 3135012 N1 - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Szeged, H-6720, Hungary Travel Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal Cited By :11 Export Date: 31 July 2020 CODEN: ANTRD Correspondence Address: Spengler, G.; Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Dóm tér 10, Hungary; email: spengler.gabriella@med.u-szeged.hu Chemicals/CAS: doxorubicin, 23214-92-8, 25316-40-9; thioridazine, 130-61-0, 50-52-2; verapamil, 152-11-4, 52-53-9; phenothiazine, 92-84-2; Antineoplastic Agents; Antipsychotic Agents; phenothiazine; Phenothiazines; Thioridazine AB - Thioridazine (TZ), an antipsychotic drug, renders multidrug-resistant (MDR) cancer cells susceptible to cytotoxic agents to which they were initially resistant, has anti-prolilferative activity and apoptosis-inducing properties in various tumor cell lines and cancer stem cells. Whereas the anti-proliferative activity takes place at high concentrations that ensure the intercalation of the compound between nucleic bases (especially rich in G/C bases), much lower concentrations inhibit the export function of the ABCB1 (P-glycoprotein), which is responsible for the MDR phenotype of the cancer cell. The co-administration of TZ with doxorubicin inhibits efflux of doxorubicin and, hence, increases the intracellular concentration of anticancer drug. The (+) and (-) enantiomers of TZ have the same activities as TZ. The main focus of this review is to present extensive evidence provided by our work, confirmed by much later studies, as it supports adjuvant use of TZ with an anticancer drug for MDR cancer therapy. LA - English DB - MTMT ER - TY - JOUR AU - Zeslawska, E AU - Kincses, Annamária AU - Spengler, Gabriella AU - Nitek, W AU - Wyrzuc, K AU - Kiec-Kononowicz, K AU - Handzlik, J TI - The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies JF - BIOORGANIC & MEDICINAL CHEMISTRY J2 - BIOORGAN MED CHEM VL - 24 PY - 2016 IS - 12 SP - 2815 EP - 2822 PG - 8 SN - 0968-0896 DO - 10.1016/j.bmc.2016.04.055 UR - https://m2.mtmt.hu/api/publication/3083954 ID - 3083954 N1 - Acknowledgments Authors thank to students: Justyna Bryła (Jagiellonian University, Medical College, Poland), Ana Rita Borba and Catia Seabra (University Porto, Portugal) for their participation in the chemical synthesis works. The equipment used for X-ray data collection was purchased thanks to the financial support of the European Regional Development Fund in the framework of the Polish Innovation Economy Operational Program (contract no. POIG.02.01.00-12-023/08). The work was partly supported by Polish programs of statutory research K/ZDS/005593 and K/ZDS/004689 (Jagiellonian University-Medical College) and by Pedagogical University of Cracow. AB - A series of arylpiperazine derivatives of hydantoin-3-acetate, including previously obtained 5,5-diphenylhydantoin (1-7) and new-synthesized spirofluorene-hydantoin derivatives (8-12), were investigated in the search for new inhibitors of the tumour multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp, ABCB1) overexpressed in mouse T-lymphoma cells. Synthesis of new compounds (8-12) was performed. Crystal structures of two compounds (8 and 11) were determined by X-ray diffraction method. The conformations of the investigated molecules (8 and 11) in the crystalline samples are different. The bent conformation seems to be more favourable for biological activity than the extended one. The efflux pump inhibitory properties of the compounds 1-12 were evaluated in the fluorescence uptake assay using rhodamine 123 dye in mouse T-lymphoma model in vitro. Their cytotoxic action was examined, too. All compounds with methyl acetate moiety displayed high potency to inhibit the MDR efflux pump. The most active compound, methyl 2-(1-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-5,5-diphenylhydantoin-3-yl)a cetate (5), tested at 1/10 of verapamil concentration displayed the 9-fold higher P-gp inhibitory action. LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Hamdoun, S AU - Spengler, Gabriella AU - Martins, Ana AU - Vincze, I AU - Efferth, T AU - Molnár, József TI - Substituted steroidal compounds containing amino and amido groups reverse multidrug resistance of mouse T-lymphoma and two human prostate cancer cell lines in vitro JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 35 PY - 2015 IS - 4 SP - 2105 EP - 2112 PG - 8 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2879234 ID - 2879234 N1 - Megjegyzés-24755981 N1 Funding Details: SFRH/BPD/81118/2011, FCT, Fundação para a Ciência e a Tecnologia AB - BACKGROUND: Resistance to chemotherapy is a main problem in cancer. The search for new effective compounds that can increase sensitivity of resistant cells to existing chemotherapeutics is an urgent need. In previous studies, it has been demonstrated that steroid derivatives showed promising results concerning their capacity to modulate resistance of multidrug-resistant cell lines. MATERIALS AND METHODS: Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multidrug resistance, apoptosis induction, and interaction with doxorubicin on multidrug resistant human ATP-binding cassette, sub-family B, member 1 (ABCB1) gene-transfected mouse T-lymphoma cell line, and human PC-3 and LNCaP prostate cancer cell lines in vitro. The steroidal interaction with P-glycoprotein (ABCB1) was investigated by molecular docking. RESULTS: Both the activity of steroid derivatives on inhibition of the ABCB1 pump and their interaction with doxorubicin are dependent on the substituent groups of the investigated steroidal structures. Even though the investigated steroid derivatives were found to have limited antiproliferative effect on the three different cancer cell lines, in combination with doxorubicin, most of them acted as good potentiators. The binding energies from molecular docking ranged from -6.43 to -9.88 kcal/mol. The predicted inhibition constants ranged from 0.1 to 10.1 muM. A significant negative correlation was found between binding energy and fluorescence activity ratio (R=-0.5, p=0.015). CONCLUSION: The effective compounds can be candidates of model molecules for possible application in the treatment of multidrug resistant cancer in rational drug design. LA - English DB - MTMT ER - TY - CHAP AU - Kovács, Dávid AU - Igaz, Nóra AU - Keskeny, Csilla AU - Szőke, Krisztina AU - Rigó, Réka AU - Tóth, Tímea AU - Spengler, Gabriella AU - Kónya, Zoltán AU - Boros, Imre Miklós AU - Csontné Kiricsi, Mónika ED - Róbert, Hohol ED - Zsuzsanna, Heiszler ED - Nóra, Éles-Etele TI - Resistance Mechanisms in Silver-Citrate Nanoparticle Treated Cancer Cells T2 - Hungarian Molecular Life Sciences 2015 PB - Diamond Congress Kft. CY - Budapest SN - 9786155270154 PY - 2015 SP - 175 EP - 175 PG - 1 UR - https://m2.mtmt.hu/api/publication/2879380 ID - 2879380 LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - ENRIQUE, DOMÍNGUEZ-ÁLVAREZ AU - JADWIGA, HANDZLIK AU - Burián, Katalin AU - Spengler, Gabriella TI - REVERSAL OF MULTIDRUG RESISTANCE BY SELENOESTER DERIVATIVES JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 62 PY - 2015 IS - Suppl. SP - 154 EP - 154 PG - 1 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3063460 ID - 3063460 N1 - kötet DOI: http://dx.doi.org/10.1556/030.62.2015.Suppl.2 LA - English DB - MTMT ER - TY - JOUR AU - Matos, AM AU - Reis, M AU - Spengler, Gabriella AU - Molnár, József AU - Duarte, N AU - Ferreira, MJU TI - Exploring epoxylathyrane derivatives to overcome ABCB1-mediated multidrug resistance in human colon adenocarcinoma cells JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 81 PY - 2015 IS - 16 SP - 1454 EP - 1455 PG - 2 SN - 0032-0943 UR - https://m2.mtmt.hu/api/publication/3040889 ID - 3040889 LA - English DB - MTMT ER - TY - JOUR AU - Matos, AM AU - Reis, M AU - Duarte, N AU - Spengler, Gabriella AU - Molnár, József AU - Ferreira, MJ TI - Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 78 PY - 2015 IS - 9 SP - 2215 EP - 2228 PG - 14 SN - 0163-3864 DO - 10.1021/acs.jnatprod.5b00370 UR - https://m2.mtmt.hu/api/publication/2951177 ID - 2951177 AB - Epoxyboetirane A (1), a macrocyclic diterpene that was found to be inactive as an ABCB1 modulator, was submitted to several chemical transformations, aimed at generating a series of compounds with improved multidrug resistance (MDR)-modifying activity. Overall, 23 new derivatives were prepared, in addition to the already reported epoxylathyrol (2) and methoxyboetirol (3). Their anti-MDR potential was assessed through both functional and chemosensitivity assays on resistant human colon adenocarcinoma and human ABCB1-gene transfected L5178Y mouse lymphoma cells. Structure-activity relationship analysis showed that different substitution patterns led to distinct ABCB1 inhibitory activities, although intrinsic cellular characteristics seemed to influence the modulatory behavior. A considerable enhancement in MDR-modifying activity was observed for aromatic compounds in both cell lines, particularly in 3,17-disubstituted esters derived from 3, a Payne-rearranged Michael adduct of 2. All compounds tested were revealed to interact synergistically with doxorubicin, and ATPase inhibition by three representative MDR-modifying compounds was also investigated. On account of its outstanding ABCB1 inhibitory activity at 0.2 muM and overall remarkable bioactive profile, methoxyboetirane B (22) was found to be a new promising lead for MDR-reversing anticancer drug development. LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Ocsovszki, Imre AU - Tonki, AS AU - Saijo, R AU - Watanabe, G AU - Kawase, M AU - Molnár, József TI - Fluorinated beta-Diketo Phosphorus Ylides Are Novel Inhibitors of the ABCB1 Efflux Pump of Cancer Cells. JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 35 PY - 2015 IS - 11 SP - 5915 EP - 5919 PG - 5 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2962208 ID - 2962208 AB - Efflux pump inhibitors are attractive compounds that reverse multidrug resistance (MDR) in cancer cells. In the present study, 10 phosphorus ylides (P-ylides) were compared based on their MDR-reverting activity in human ATP-binding cassette sub-family B member 1 (ABCB1; P-glycoprotein) gene-transfected L5178Y mouse T-lymphoma cells. Among them, three P-ylides, Ph3P=C(COCF3)COPh, Ph3P=C(COC2F5)COPh and Ph3P=C(COC3F7)COPh were identified as selectively modulating the ABCB1 pump. These compounds, with low cytotoxicity against mouse T-lymphoma cells, exhibited more potency than the positive control ABCB1 inhibitor verapamil. LA - English DB - MTMT ER - TY - GEN AU - Spengler, Gabriella AU - Mosolygó, Tímea AU - Molnár, József AU - Csonka, Andrea AU - Csonka, Ákos AU - Amaral, Leonard AU - Burián, Katalin TI - The anti-chlamydial effect of phenothiazines and disiloxane derivatives PY - 2015 UR - https://m2.mtmt.hu/api/publication/2901849 ID - 2901849 N1 - [Abstract (eposter)] LA - English DB - MTMT ER - TY - JOUR AU - Takács, Daniella AU - Csonka, Ákos AU - Horváth, Ádám AU - Windt, Tímea AU - Gajdács, Márió AU - Riedl, Zsuzsanna AU - Hajós, György AU - Amaral, L AU - Molnár, József AU - Spengler, Gabriella TI - Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines. JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 35 PY - 2015 IS - 6 SP - 3245 EP - 3251 PG - 7 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2901785 ID - 2901785 AB - BACKGROUND: The most common mechanism that reduces the efficacy of anticancer agents is overexpression of ATP-binding cassette (ABC) drug transporters. Phenothiazines and structurally-related compounds can sensitize multidrug-resistant (MDR) cells to chemotherapeutics. MATERIALS AND METHODS: Phenothiazine derivatives were investigated regarding their anticancer and MDR-reversing effect on colonic adenocarcinoma cells. The anti-proliferative and cytotoxic effects of the derivatives were assessed by the thiazolyl blue tetrazolium bromide (MTT) method, the modulation of the ABCB1 activity was measured by rhodamine 123 accumulation assay using flow cytometry. RESULTS: All phenothiazines exhibited potent cytotoxic effect on the sensitive and MDR colon adenocarcinoma cell lines. The inhibition of the ABCB1 transporter was greater in the presence of the phenothiazine derivatives than for the known ABCB1 inhibitor verapamil. CONCLUSION: It can be concluded that these derivatives show synergism in the presence of doxorubicin and could have potential as ABCB1 inhibitors. LA - English DB - MTMT ER - TY - JOUR AU - Mosolygó, Tímea AU - MARION, SZATMÁRI AU - Molnár, József AU - Csonka, Andrea AU - Csonka, Ákos AU - LEONARD, AMARAL AU - Burián, Katalin AU - Spengler, Gabriella TI - NEW PERSPECTIVES IN THE TREATMENT OF CHLAMYDIA TRACHOMATIS INFECTIONS: PHENOTHIAZINES AND DISILOXANE DERIVATIVES AS POTENTIAL ANTI-CHLAMYDIAL AGENTS JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 62 PY - 2015 IS - Suppl. 1. SP - 182 EP - 183 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/3063503 ID - 3063503 N1 - kötet DOI: http://dx.doi.org/10.1556/030.62.2015.Suppl.2 LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Spengler, Gabriella AU - Martins, Ana AU - Irén, Vincze AU - Molnár, József TI - COMPARISON OF CYTOTOXICITY OF BUTYL-OXI-CARBONYL SUBSTITUTED STEROIDAL COMPOUNDS ON DIFFERENT CANCER CELL LINES IN VITRO JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 34 PY - 2014 IS - 10 SP - 5870 EP - 5871 PG - 2 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2757032 ID - 2757032 N1 - Meeting Abstract: 128 LA - English DB - MTMT ER - TY - JOUR AU - Amaral, Leonard AU - Martins, Ana AU - Spengler, Gabriella AU - Molnár, József TI - Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 4 PY - 2014 PG - 11 SN - 1663-9812 DO - 10.3389/fphar.2013.00168 UR - https://m2.mtmt.hu/api/publication/2497680 ID - 2497680 LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Ágnes Míra AU - Spengler, Gabriella AU - D, Takács AU - Zs, Riedl AU - Gy, Hajós AU - L, Amaral AU - Molnár, József TI - Multidrug resistance reversal by phenothiazines on p glycoprotein-related resistance of colon adenocarcinoma cells JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 34 PY - 2014 IS - 10 SP - 6196 EP - 6197 PG - 2 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2757039 ID - 2757039 N1 - Meeting Abstract: 634 LA - English DB - MTMT ER - TY - JOUR AU - Cátia, Vieira AU - Noélia, Duarte AU - Mariana, A Reis AU - Spengler, Gabriella AU - Ana, Margarida Madureira AU - Molnár, József AU - Maria-José, U Ferreira TI - Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes JF - BIOORGANIC & MEDICINAL CHEMISTRY J2 - BIOORGAN MED CHEM VL - 22 PY - 2014 IS - 22 SP - 6392 EP - 6400 PG - 9 SN - 0968-0896 DO - 10.1016/j.bmc.2014.09.041 UR - https://m2.mtmt.hu/api/publication/2769946 ID - 2769946 LA - English DB - MTMT ER - TY - CONF AU - Csonka, Ákos AU - Spengler, Gabriella AU - Martins, Ana AU - Ocsovszki, Imre AU - Chritsten, Jorn B AU - Hendricks, Oliver AU - Kristiansen, Jette E AU - Amaral, Leonard AU - Molnár, József TI - Anticancer activity of thioridazine stereoisomers T2 - ICACT 2014 PY - 2014 UR - https://m2.mtmt.hu/api/publication/2526922 ID - 2526922 LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Diána AU - Spengler, Gabriella AU - Molnár, József AU - Gábor, Tax AU - Kornélia, Szabó AU - Rovó, László TI - Analysis of the interaction of normal human fibroblasts and different cancer cells in mixed cultures by xcelligence studies JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 34 PY - 2014 IS - 10 SP - 6197 EP - 6197 PG - 1 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2757043 ID - 2757043 LA - English DB - MTMT ER - TY - CONF AU - Spengler, Gabriella AU - Daniella, Takács AU - Horváth, Ádám AU - Zsuzsanna, Riedl AU - György, Hajós AU - Molnár, József AU - Burián, Katalin ED - Charles, M Dozois TI - The role of chirality in the efflux pump inhibiting properties of phenothiazine derivatives on the bacterial AcrAB-TolC system T2 - International Congress of Bacteriology and Applied Microbiology during the International Union of Microbiological Societies General Assembly PY - 2014 SP - 1216 EP - 1216 PG - 1 UR - https://m2.mtmt.hu/api/publication/2820018 ID - 2820018 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Ilona, Mucsi AU - Ferenc, Uher AU - Peter, Hegyes AU - Orsolya, Csuka AU - Molnár, József AU - Zoltán, Kiss TI - Thioxanthone compounds to reduce tumor growth, cancer cachexia and cancer treatment-related bone marrow toxicity JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 34 PY - 2014 IS - 10 SP - 6180 EP - 6180 PG - 1 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2757059 ID - 2757059 N1 - Meeting Abstract: 612 LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Dávid AU - Igaz, Nóra AU - Keskeny, C AU - Toth, T AU - Spengler, Gabriella AU - Kónya, Zoltán AU - Boros, Imre Miklós AU - Csontné Kiricsi, Mónika TI - Resistance mechanisms in silver-citrate nanoparticles treated colon cancer cells JF - FEBS JOURNAL J2 - FEBS J VL - 281 PY - 2014 IS - Suppl 1 SP - 161 EP - 162 PG - 2 SN - 1742-464X UR - https://m2.mtmt.hu/api/publication/2817308 ID - 2817308 N1 - Nincs jelölve levelező szerzőség a közleményen (csonkap5) LA - English DB - MTMT ER - TY - JOUR AU - Molnár, József AU - Mándi, Yvette AU - Spengler, Gabriella AU - Haszon, I AU - Turi, S AU - Kásler, Miklós AU - Amaral, L TI - Synergism between Antiplasmid Promethazine and Antibiotics In Vitro and In Vivo JF - BIOCHEMISTRY AND PHARMACOLOGY J2 - BIOCHEM PHARMACOL VL - 3 PY - 2014 IS - 4 PG - 5 SN - 2167-0501 DO - 10.4172/2167-0501.1000139 UR - https://m2.mtmt.hu/api/publication/3049294 ID - 3049294 LA - English DB - MTMT ER - TY - JOUR AU - Neto, S AU - Vieira, C AU - Matos, A M AU - Monico, A AU - Ferreira, R AU - Reis, M AU - Pedro, C AU - Madureira, A M AU - Spengler, Gabriella AU - Molnár, József AU - Duarte, N AU - Ferreira, M J U TI - Lathyrane diterpenes from Euphorbia boetica and Euphorbia pedroi: Promising ABCB1 modulators for overcoming multidrug resistance JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 80 PY - 2014 IS - 16 SP - 1412 EP - 1412 PG - 1 SN - 0032-0943 UR - https://m2.mtmt.hu/api/publication/2866957 ID - 2866957 LA - English DB - MTMT ER - TY - CHAP AU - Igaz, Nóra AU - Kovács, Dávid AU - Csilla, Keskeny AU - Tímea, Tóth AU - Spengler, Gabriella AU - Kónya, Zoltán AU - Boros, Imre Miklós AU - Csontné Kiricsi, Mónika ED - Kónya, Zoltán ED - Kukovecz, Ákos TI - Resistance Mechanisms in Silver-Citrate Nanoparticle Treated Colon Cancer Cells T2 - SIWAN6: 6th Szeged International Workshop on Advances in Nanoscience PB - Akadémiai Kiadó CY - Budapest SN - 9789630595544 PY - 2014 SP - 97 EP - 98 PG - 2 UR - https://m2.mtmt.hu/api/publication/2821479 ID - 2821479 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Takács, Daniella AU - Horváth, Ádám AU - Szabó, Ágnes Míra AU - Riedl, Zsuzsanna AU - Hajós, György AU - Molnár, József AU - Burián, Katalin TI - Efflux Pump Inhibiting Properties of Racemic Phenothiazine Derivatives and their Enantiomers on the Bacterial AcrAB-TolC System. JF - IN VIVO J2 - IN VIVO VL - 28 PY - 2014 IS - 6 SP - 1071 EP - 1075 PG - 5 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/2774700 ID - 2774700 N1 - TÁMOP-4.2.2.A-11/1/KONV-2012-0035; TÁMOP 4.2.4.B/2-11/1 2012-0001 (Hungary). This research was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TÁMOP 4.2.4.A/2-11-1-2012-0001 ‘National Excellence Program’. AB - Background/Aim: Bacterial resistance to antibiotics has become a serious problem in antibacterial chemotherapy and resistance of bacteria to chemically-unrelated anti-microbial agents can be associated with the over-expression of efflux pumps. The simultaneous therapy with efflux pump inhibitors (EPIs) could be a solution to improve the effectiveness of antibiotics. The response of an organism to an EPI often depends on how that molecule fits a particular site of a protein. Because enantiomers of a given compound rotate plane-polarized light in a solution by the same angle but in opposite directions, the rational drug design should take the chirality into account if there is a difference between the racemic compound and its enantiomers. Materials and Methods: The main goal of the present study was to elucidate the role of chirality of N-hydroxyalkyl-2-aminophenothiazines as effective EPIs by an automated method that uses the general efflux pump substrate ethidium bromide (EB) for the assessment of AcrAB-TolC system of wild-type Escherichia coli K-12 AG100. It has been shown that the most active EPIs among the N-hydroxyalkyl-2-aminophenothiazines were the compounds rac-3i, (+)-3i, and (-)-3i by modulating the AcrAB-TolC efflux pump. Conclusion: Comparison of effects of enantiomeric pairs revealed that their activities were similar to that of racemic derivatives. Moreover, there was no significant difference between the racemic compounds and their enantiomers related to their antibacterial and efflux pump inhibiting effects. LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Takács, Daniella AU - Horváth, Ádám AU - Riedl, Zsuzsanna AU - Hajós, György AU - Amaral, L AU - Molnár, József TI - Multidrug Resistance Reversing Activity of Newly Developed Phenothiazines on P-glycoprotein (ABCB1)-related Resistance of Mouse T-Lymphoma Cells. JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 34 PY - 2014 IS - 4 SP - 1737 EP - 1741 PG - 5 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2583773 ID - 2583773 N1 - Megjegyzés-24478624 N1 Funding Details: SFRH/BCC/51099/2010, FCT, Fundação para a Ciência e a Tecnologia AB - BACKGROUND: Phenothiazines have anticancer properties and are able to reverse the multidrug resistance of neoplastic cells by inhibiting the ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein (ABCB1 or P-glycoprotein) activity. MATERIALS AND METHODS: A series of new phenothiazine derivatives was investigated regarding their ABCB1-modulating effect on multidrug resistant mouse T-lymphoma cells by rhodamine 123 accumulation assay and real-time ethidium bromide accumulation assay. RESULTS: The phenothiazine derivatives exhibited a potent anticancer effect on the parental cell line and on its multidrug-resistant mouse T-lymphoma subline overexpressing the ABCB1 transporter. The inhibition of the ABCB1 transporter in the presence of the newly-developed phenothiazines was greater than that for the known ABCB1 inhibitors thioridazine and verapamil. CONCLUSION: Based on the chemical structures and biological activity, compounds with bivalent sulfur atom in the phenothiazine ring demonstrated marked ABCB1-modulating effect, however, other derivatives with halogen or amide substitutions were ineffective. LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Takacs, Daniella AU - Riedl, Zsuzsanna AU - Hajos, György AU - Amaral, Leonard AU - Molnár, József TI - Multidrug resistance reversing activity of newly developed phenothiazines on p glycoprotein (abcb1)-related resistance in different cancer models JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 34 PY - 2014 IS - 10 SP - 6180 EP - 6181 PG - 2 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2779840 ID - 2779840 N1 - Meeting Abstract: 613 LA - English DB - MTMT ER - TY - CHAP AU - Spengler, Gabriella AU - Takács, Daniella AU - Handzlik, Jadwiga AU - Kiec-Kononowicz, Katarzyna AU - Amaral, Leonard ED - Szélpál, Szilárd TI - INHIBITORS OF EFFLUX PUMPS IN GRAM-NEGATIVE BACTERIA TO COMBAT MULTIDRUG RESISTANCE T2 - I. Innovation in Science - Doctoral Student Conference 2014 PB - Magyar Kémikusok Egyesülete (MKE) CY - Szeged SN - 9789639970526 PY - 2014 SP - 165 EP - 166 PG - 2 UR - https://m2.mtmt.hu/api/publication/2583760 ID - 2583760 LA - English DB - MTMT ER - TY - CONF AU - Spengler, Gabriella AU - Handzlik, Jadwiga AU - Szabó, Ágnes Míra AU - Karcz, Tadeusz AU - Olejarz, Agnieszka AU - Amaral, Leonard AU - Molnár, József AU - Kiec-Kononowicz, Katarzyna TI - Studies of phenylpiperazine derivatives of 5,5-dimethylhydantion on the modulation of multidrug efflux pumps of cancer cells T2 - ICACT 2014 PY - 2014 UR - https://m2.mtmt.hu/api/publication/2526895 ID - 2526895 LA - English DB - MTMT ER - TY - JOUR AU - Amaral, L AU - Spengler, Gabriella AU - Martins, Ana AU - Molnár, József TI - Efflux Pumps that Bestow Multi-Drug Resistance of Pathogenic Gramnegative Bacteria JF - BIOCHEMISTRY AND PHARMACOLOGY J2 - BIOCHEM PHARMACOL VL - 2 PY - 2013 IS - 3 PG - 3 SN - 2167-0501 DO - 10.4172/2167-0501.1000119 UR - https://m2.mtmt.hu/api/publication/2755751 ID - 2755751 LA - English DB - MTMT ER - TY - JOUR AU - Amaral, Leonard AU - Martins, Ana AU - Spengler, Gabriella AU - Hunyadi, Attila AU - Molnár, József TI - The mechanism by which the phenothiazine thioridazine contributes to cure problematic drug-resistant forms of pulmonary tuberculosis: Recent patents for "new use" JF - RECENT PATENTS ON ANTI-INFECITVE DRUG DISCOVERY J2 - REC PATENTS ANTI-INFECT DRUG DISCOV VL - 8 PY - 2013 IS - 3 SP - 206 EP - 212 PG - 7 SN - 1574-891X DO - 10.2174/1574891X08666131210141521 UR - https://m2.mtmt.hu/api/publication/2475746 ID - 2475746 AB - At this moment, over half million patients suffer from multi-drug resistant tuberculosis (MDRTB) according to the data from the WHO. A large majority is terminally ill with essentially incurable pulmonary tuberculosis. This herein mini-review provides the experimental and observational evidence that a specific phenothiazine, thioridazine, will contribute to cure any form of drug-resistant tuberculosis. This antipsychotic agent is no longer under patent protection for its initial use. The reader is informed on the recent developments in patenting this compound for "new use" with a special emphasis on the aspects of drug-resistance, and, given that economic motivation can stimulate the use of this drug as an antitubercular agent, future prospects are also discussed. LA - English DB - MTMT ER - TY - JOUR AU - Csonka, Ákos AU - Spengler, Gabriella AU - Martins, Ana AU - Ocsovszki, Imre AU - Christensen, JB AU - Hendricks, O AU - Kristiansen, JE AU - Amaral, L AU - Molnár, József TI - Effect of thioridazine stereoisomers on the drug accumulation of mouse lymphoma and human prostate cancer cell lines in vitro. JF - IN VIVO J2 - IN VIVO VL - 27 PY - 2013 IS - 6 SP - 815 EP - 820 PG - 6 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/2470103 ID - 2470103 AB - BACKGROUND: Cancer cells become refractory to chemotherapy as a consequence of their overexpression of multidrug transporters. MATERIALS AND METHODS: The anticancer and multidrug resistance (MDR) reversal effects of the racemic form and the two enantiomers of thoridazine were investigated on a mouse T-lymphoma cell line over-expressing the ATP-binding cassette, subfamily-B (MDR/TAP), member 1 (ABCB1) transporter (also known as P-glycoprotein) and on human PC3 prostate cancer cell line by 3-(4.5-dimethylthiazolyl-2)-2.5-diphenyl tetrazolium bromide (MTT) assay. The modulation of ABCB1 transporter activity was studied by rhodamine123 accumulation, the apoptosis-inducing effect was investigated using fluorescein isothiocyanate (FITC)-labeled annexin V and propidium iodide. RESULTS: The thioridazine racemic and (+) and (-) enantiomers were similarly effective. Drug accumulation by MDR mouse T-lymphoma cells was moderately modified in the presence of thioridazine derivatives. Thioridazine induced apoptosis of the MDR cancer cell line, but there was no significant apoptotic effect on the PC3 cell line. CONCLUSION: Apparently, the chirality of thioridazine has no importance in the inhibition of MDR phenotype of cancer cells. LA - English DB - MTMT ER - TY - JOUR AU - Molnár, József AU - Mucsi, Ilona AU - Engi, Helga AU - Spengler, Gabriella AU - Amaral, Leonard AU - Zalatnai, Attila AU - Wang, Qi AU - Shlomo, Ben Efraim TI - The Role of Stroma in Tumour-Host Co-Existence: Some Perspectives in Stroma-Targeted Therapy of Cancer JF - BIOCHEMISTRY AND PHARMACOLOGY J2 - BIOCHEM PHARMACOL VL - 2 PY - 2013 IS - 1 PG - 6 SN - 2167-0501 DO - 10.4172/2167-0501.1000107 UR - https://m2.mtmt.hu/api/publication/2470652 ID - 2470652 LA - English DB - MTMT ER - TY - JOUR AU - Mosolygó, Tímea AU - Spengler, Gabriella AU - Endrész, Valéria AU - Laczi, Krisztián AU - Perei, Katalin AU - Burián, Katalin TI - IL-17E Production Is Elevated in the Lungs of Balb/c Mice in the Later Stages of Chlamydia muridarum Infection and Re-infection JF - IN VIVO J2 - IN VIVO VL - 27 PY - 2013 IS - 6 SP - 787 EP - 792 PG - 6 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/2473515 ID - 2473515 N1 - Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary Department of Biotechnology, University of Szeged, Szeged, Hungary Cited By :4 Export Date: 3 December 2019 CODEN: IVIVE Correspondence Address: Burián, K.; Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary; email: burian.katalin@med.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Mosolygó, Tímea AU - Spengler, Gabriella AU - Balogh, Emese Petra AU - Endrész, Valéria AU - Laczi, Krisztián AU - Perei, Katalin AU - Burián, Katalin TI - IL-17E production is elevated in the lungs of BALB/C mice in the later stages of Chlamydia muridarum infection and reinfection JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 60 PY - 2013 IS - Suppl.1 SP - 189 EP - 190 PG - 2 SN - 1217-8950 UR - https://m2.mtmt.hu/api/publication/2465663 ID - 2465663 LA - English DB - MTMT ER - TY - CHAP AU - Amaral, L AU - Fanning, S AU - Spengler, Gabriella AU - Rodrigues, L AU - Iversen, C AU - Martins, M AU - Martins, A AU - Viveiros, M AU - Couto, I TI - Genetic regulation, physiology, assessment and inhibition of efflux pumps responsible for multi-drug resistant phenotypes of bacterial pathogens T2 - Bacterial Pathogens: Virulence Mechanisms, Diagnosis and Management PB - Nova Science Publishers SN - 9781620818879 PB - Nova Science Publishers PY - 2012 SP - 91 EP - 116 PG - 26 UR - https://m2.mtmt.hu/api/publication/24452948 ID - 24452948 N1 - Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira, 96, 1349-008 Lisboa, Portugal UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Lisboa, Portugal COST ACTION BM0701 (ATENS) of the European Commission/European Science Foundation, Portugal Centres for Food Safety and Food-borne Zoonomics, UCD Veterinary Sciences Centre, University College Dublin, Belfield, Dublin, Ireland Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal Export Date: 3 June 2021 Correspondence Address: Amaral, L.; Unit of Mycobacteriology, Rua da Junqueira, 96, 1349-008 Lisboa, Portugal; email: lamaral@ihmt.unl.pt LA - English DB - MTMT ER - TY - JOUR AU - Amaral, L AU - Spengler, Gabriella AU - Martins, Ana AU - Armada, A AU - Handzlik, J AU - Kiec-Kononowicz, K AU - Molnár, József TI - Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 32 PY - 2012 IS - 7 SP - 2947 EP - 2957 PG - 12 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2168322 ID - 2168322 N1 - Megjegyzés-23086624 N1 : Chemicals/CASphenytoin, 57-41-0, 630-93-3; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; verapamil, 152-11-4, 52-53-9; ATP-Binding Cassette Transporters; Anti-Bacterial Agents; Antineoplastic Agents Megjegyzés-23167234 N1 : Chemicals/CASphenytoin, 57-41-0, 630-93-3; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; verapamil, 152-11-4, 52-53-9; ATP-Binding Cassette Transporters; Anti-Bacterial Agents; Antineoplastic Agents Group of Mycobacteriology, Unit of Medical Microbiologiy, Universidade Nova de Lisboa, Lisbon, Portugal Centre for Malaria and other Tropical Diseases, Universidade Nova de Lisboa, Lisbon, Portugal Unit of Parasitology and Medical Microbiology, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, Portugal Cost Action BM0701 of the European Commission/European Science Foundation, University of Szeged, Szeged, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Krakow, Poland Cited By :17 Export Date: 8 February 2020 CODEN: ANTRD Correspondence Address: Amaral, L.; Unidade de Microbiologia, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, 1349-008 Lisbon, Portugal; email: lamaral@ihmt.unl.pt Chemicals/CAS: phenytoin, 57-41-0, 630-93-3; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; verapamil, 152-11-4, 52-53-9; ATP-Binding Cassette Transporters; Anti-Bacterial Agents; Antineoplastic Agents Tradenames: dilantin; hy 84; mc 04 124; mc 207 110; sila 409; sila 421 Group of Mycobacteriology, Unit of Medical Microbiologiy, Universidade Nova de Lisboa, Lisbon, Portugal Centre for Malaria and other Tropical Diseases, Universidade Nova de Lisboa, Lisbon, Portugal Unit of Parasitology and Medical Microbiology, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, Portugal Cost Action BM0701 of the European Commission/European Science Foundation, University of Szeged, Szeged, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Krakow, Poland Cited By :21 Export Date: 3 June 2021 CODEN: ANTRD Correspondence Address: Amaral, L.; Unidade de Microbiologia, , 1349-008 Lisbon, Portugal; email: lamaral@ihmt.unl.pt AB - Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well. Control over the efflux pump that bestows multidrug resistance has been a goal of research during the past decade. As a consequence of this search for inhibitors of efflux pumps, it has been noted that many agents which affect the efflux pump system of bacteria also have similar activity against efflux pumps of drug-resistant cancer cells. This review aims to identify such agents. LA - English DB - MTMT ER - TY - CHAP AU - Amaral, Leonard AU - Martins, Ana AU - Spengler, Gabriella AU - Martins, Marta AU - Rodrigues, Liliana AU - McCusker, Matthew AU - Ntokou, Eleni AU - Cerca, Pedro AU - Machado, Lisa AU - Viveiros, Miguel AU - Couto, Isabel AU - Fanning, Seamus AU - Kristiansen, Jette AU - Molnár, József ED - Tegos, G ED - Mylonakis, E TI - Structure, Genetic Regulation, Physiology and Function of the AcrAB-TolC Efflux Pump of Escherichia coli and Salmonella T2 - Antimicrobial Drug Discovery: Emerging Strategies PB - CAB International CY - Wallingford SN - 9781845939434 T3 - Advances in Molecular and Cellular Microbiology ; 22. PY - 2012 SP - 44 EP - 61 PG - 18 DO - 10.1079/9781845939434.0044 UR - https://m2.mtmt.hu/api/publication/2444054 ID - 2444054 LA - English DB - MTMT ER - TY - JOUR AU - Dymek, A AU - Armada, A AU - Handzlik, J AU - Viveiros, M AU - Spengler, Gabriella AU - Molnár, József AU - Kiec-Kononowicz, K AU - Amaral, L TI - The Activity of 16 New Hydantoin Compounds on the Intrinsic and Overexpressed Efflux Pump System of Staphylococcus aureus JF - IN VIVO J2 - IN VIVO VL - 26 PY - 2012 IS - 2 SP - 223 EP - 229 PG - 7 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/1879153 ID - 1879153 N1 - Megjegyzés-22257244 Chemicals/CAS: ethidium bromide, 1239-45-8; oxacillin, 1173-88-2, 66-79-5, 7240-38-2 AB - Aim: To evaluate a new series of 16 hydantoin derivatives for activity against the intrinsic and overexpressed efflux pumps of the ATTC 25923 Staphylococcus aureus and the clinical Staphylococcus aureus HPV-107 strain, respectively. MATERIALS AND METHODS: The hydantoin compounds were evaluated for activity against the efflux pumps of the ATTC 25923 S. aureus and the clinical S. aureus HPV-107 strains by the aid of the automated ethidium bromide method. Compounds that inhibited the efflux pumps of either strain were evaluated for ability to reduce or reverse resistance of these strains to oxacillin. RESULTS: Although most of the hydantoins inhibited the efflux pumps of the ATTC strain, none reduced the resistance of this strain to oxacillin. In contrast, the inhibition of the Qac efflux pump present in HPV-107 was inhibited to some degree, by much higher concentrations of the hydantoin compounds than that needed for similar activity against the ATTC strain; only hydantoin PI8a significantly reduced the minimum inhibitory concentration of oxacillin against the HPV-107 strain. CONCLUSION: Hydantoin compound PI8a may have potential for therapy of a methicillin-resistant S. aureus infection whose multidrug-resistant phenotype is due to overexpression of an efflux pump. LA - English DB - MTMT ER - TY - CHAP AU - Spengler, Gabriella AU - Liliana, Rodrigues AU - Marta, Martins AU - Matthew, McCusker AU - Sofia, Santos Costa AU - Eleni, Ntokou AU - Szabó, Ágnes Míra AU - Horváth, Ádám AU - Varga, Zoltán Gábor AU - Séamus, Fanning AU - Molnár, József AU - Leonard, Amaral ED - 22, nd ECCMID TI - Stress response and resistance of Salmonella enterica serotype Enteritidis to the efflux pump inhibitor neuroleptic drug thioridazine T2 - Clinical Microbiology and Infection PB - Wiley-Blackwell CY - London PY - 2012 SP - 307 EP - 307 PG - 1 UR - https://m2.mtmt.hu/api/publication/1993467 ID - 1993467 LA - English DB - MTMT ER - TY - GEN AU - Spengler, Gabriella AU - L, Rodrigues AU - M, Martins AU - M, McCusker AU - S, Santos Costa AU - E, Ntokou AU - Szabó, Ágnes Míra AU - Horváth, Ádám AU - Varga, Zoltán Gábor AU - S, Fanning AU - Molnár, József AU - L, Amaral TI - Stress response and resistance of Salmonella enterica serotype Enteritidis to the efflux pump inhibitor neuroleptic drug thioridazine PY - 2012 UR - https://m2.mtmt.hu/api/publication/2901846 ID - 2901846 N1 - [Abstract (poster session)] LA - English DB - MTMT ER - TY - JOUR AU - Handzlik, J AU - Spengler, Gabriella AU - Mastek, B AU - Dela, A AU - Molnár, József AU - Amaral, L AU - Kieć-Kononowicz, K TI - 5-Arylidene(thio)hydantoin derivatives as modulators of cancer efflux pump JF - ACTA POLONIAE PHARMACEUTICA: DRUG RESEARCH J2 - ACTA POL PHARM VL - 69 PY - 2012 IS - 1 SP - 149 EP - 156 PG - 8 SN - 0001-6837 UR - https://m2.mtmt.hu/api/publication/1894951 ID - 1894951 N1 - 2nd Place Award in the Young Scientists Presentations Competition during LA - English DB - MTMT ER - TY - JOUR AU - Martins, Ana AU - Dymek, A AU - Handzlik, J AU - Spengler, Gabriella AU - Armada, A AU - Molnár, József AU - Kiec-Kononowicz, K AU - Amaral, L TI - Activity of Fourteen New Hydantoin Compounds on the Human ABCB1 Efflux Pump JF - IN VIVO J2 - IN VIVO VL - 26 PY - 2012 IS - 2 SP - 293 EP - 297 PG - 5 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/1879152 ID - 1879152 N1 - Megjegyzés-22316648 Chemicals/CAS: ethidium bromide, 1239-45-8 Megjegyzés-22406570 N1 Source: Scopus N1 Language of Original Document: English N1 Chemicals/CAS: ethidium bromide, 1239-45-8 N1 References: Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E., Forman, D., Ferlay, J., Forman, D., Global Cancer Statistics (2011) CA Cancer J Clin, 61, pp. 69-90; 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Synthesis, structures and evaluation of benzodiazepine receptor binding (2002) J Heterocycl Chem, 39, pp. 243-253; Handzlik, J., Maciag, D., Kubacka, M., Mogilski, S., Filipek, B., Stadnicka, K., Kiec-Kononowicz, K., Synthesis, 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin (2008) Bioorganic and Medicinal Chemistry, 16 (11), pp. 5982-5998. , DOI 10.1016/j.bmc.2008.04.058, PII S0968089608003866; Handzlik, J., Szymańska, E., Nȩdza, K., Kubacka, M., Siwek, A., Mogilski, S., Handzlik, J., Kieć-Kononowicz, K., Pharmacophore models based studies on the affinity and selectivity toward 5-HT1A with reference to α1-adrenergic receptors among arylpiperazine derivatives of phenytoin (2010) Bioorg Med Chem, 19, pp. 1349-1360; Handzlik, J., Szymańska, E., Chevalier, J., Otrȩbska, E., Kieć-Kononowicz, K., Pagès, J.-M., Alibert, S., Amine-alkyl derivatives of hydantoin: New tool to combat resistant bacteria (2011) Eur J Med Chem, 46, pp. 5807-5816 Megjegyzés-23167235 N1 : Chemicals/CASethidium bromide, 1239-45-8; ABCB1 protein, human; Ethidium, 3546-21-2; Fluorescent Dyes; Hydantoins; P-Glycoprotein Megjegyzés-26272204 Megjegyzés-23121986 : Ana/I-6432-2012; santos, sofia/I-1637-2012; molnar, joseph/D-4375-2013; : Amaral, Leonard/I-2112-2012 Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Faculty of Pharmacy, Jagiellonian University, Medical College, Cracow, Poland Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Unit of Microbiology, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisboa, Portugal Cost Action BM0701 (ATENS) of the European Commission, Brussels, Belgium Cited By :4 Export Date: 8 February 2020 CODEN: IVIVE Correspondence Address: Amaral, L.; Unidade de Microbiologia, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008 Lisboa, Portugal; email: lamaral@ihmt.unl.pt Chemicals/CAS: ethidium bromide, 1239-45-8; ABCB1 protein, human; Ethidium, 3546-21-2; Fluorescent Dyes; Hydantoins; P-Glycoprotein Funding Agency and Grant Number: European UnionEuropean Union (EU) [TAMOP-4.2.1/B-09/1/KONV-2010-0005]; European Regional Fund; BCC by the Fundacao para a Ciencia e a Tecnologia (FCT) of Portugal [SFRH/BCC/51099/2010]; Fundacao para a Ciencia e a Tecnologia (FCT) of PortugalPortuguese Foundation for Science and Technology [EU-FSE/FEDER-PTDC/BIA-MIC/105509/2008, EU-FSE/FEDERPTDC/ SAU-FCF/102807/2008]; Szeged Foundation for Cancer Research; [K/ZDS/001915]; [501/N-COST/2009/0]; [COST action BM0701 (K/PMN/000031)] Funding text: This study was partly supported by Program K/ZDS/001915 and 501/N-COST/2009/0; COST action BM0701 (K/PMN/000031). A. Martins and G. Spengler acknowledge TAMOP-4.2.1/B-09/1/KONV-2010-0005 - Creating the Center of Excellence at the University of Szeged supported by the European Union and co-financed by the European Regional Fund. L. Amaral was supported by BCC grant SFRH/BCC/51099/2010 provided by the Fundacao para a Ciencia e a Tecnologia (FCT) of Portugal. This work was supported by EU-FSE/FEDER-PTDC/BIA-MIC/105509/2008 and EU-FSE/FEDERPTDC/ SAU-FCF/102807/2008 from the Fundacao para a Ciencia e a Tecnologia of Portugal. This work was partially funded by the Szeged Foundation for Cancer Research. AB - BACKGROUND: Multidrug resistance (MDR) is one of the major concerns in the treatment of cancer and one of the major causes of therapy failure. The overexpression of an ABC transporter, the ABCB1, is often associated with MDR in cancer. Previously it was observed that hydantoin compounds can modulate the activity of the ABCB1 pump. MATERIALS AND METHODS: Fourteen hydantoin derivatives were synthesized and studied for their capacity to increase accumulation of ethidium bromide (EB) by mouse lymphoma cancer cells that were transfected with the human ABCB1 gene and overexpress the human ABCB1 pump. RESULTS: It was observed that the accumulation of EB by the cells in the presence of four of the newly synthesized hydantoins was strongly increased. Similar but milder effects were also observed for the other seven hydantoins; the remaining three had no activity. CONCLUSION: The 14 hydantoin compounds studied belong to three different structural groups. Structure-activity relationships were studied and important molecular substituents that were possibly responsible for increased the activity of the molecules were identified. This important information may lead to the continuation of our work and to the future synthesis of more active compounds. LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Rodrigues, L AU - Martins, Ana AU - Martins, M AU - McCusker, M AU - Cerca, P AU - Machado, L AU - Costa, SS AU - Ntokou, E AU - Couto, I AU - Viveiros, M AU - Fanning, S AU - Molnár, József AU - Amaral, L TI - Genetic response of Salmonella enterica serotype Enteritidis to thioridazine rendering the organism resistant to the agent JF - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS J2 - INT J ANTIMICROB AG VL - 39 PY - 2012 IS - 1 SP - 16 EP - 21 PG - 6 SN - 0924-8579 DO - 10.1016/j.ijantimicag.2011.08.013 UR - https://m2.mtmt.hu/api/publication/1854097 ID - 1854097 N1 - Megjegyzés-22237233 Chemicals/CAS: palmitic acid, 57-10-3; thioridazine, 130-61-0, 50-52-2 Megjegyzés-22287060 Chemicals/CAS: palmitic acid, 57-10-3; thioridazine, 130-61-0, 50-52-2; AcrB protein, Salmonella enterica; Anti-Bacterial Agents; Bacterial Proteins; Culture Media; Membrane Transport Proteins; Thioridazine, 50-52-2 Megjegyzés-23408453 Megjegyzés-22016396 : FN Thomson Reuters Web of Knowledge LA - English DB - MTMT ER - TY - JOUR AU - Amaral, L AU - Cerca, P AU - Spengler, Gabriella AU - Machado, L AU - Martins, Ana AU - Couto, I AU - Viveiros, M AU - Fanning, S AU - Pages, JM TI - Ethidium bromide efflux by Salmonella: modulation by metabolic energy, pH, ions and phenothiazines JF - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS J2 - INT J ANTIMICROB AG VL - 38 PY - 2011 IS - 2 SP - 140 EP - 145 PG - 6 SN - 0924-8579 DO - 10.1016/j.ijantimicag.2011.03.014 UR - https://m2.mtmt.hu/api/publication/1822630 ID - 1822630 N1 - Megjegyzés-22257251 Chemicals/CAS: carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; carrier protein, 80700-39-6; ethidium bromide, 1239-45-8; glucose, 50-99-7, 84778-64-3; orthovanadic acid, 14333-18-7; sodium, 7440-23-5; thioridazine, 130-61-0, 50-52-2; water, 7732-18-5; Culture Media; Ethidium, 3546-21-2; Ionophores; Phenothiazines LA - English DB - MTMT ER - TY - JOUR AU - Li, EC AU - Zhang, JH AU - Wang, JR AU - Gao, F AU - Yang, ZH AU - Meng, Q AU - Zhang, QQ AU - Li, N AU - Huang, M AU - Spengler, Gabriella AU - Molnár, József AU - Wang, Q TI - Prevention of VP-16 Resistance by a Disiloxane, SILA409: Effects of SILA409 on the Expression of GRP78 in NCI-H446 Human Small Cell Lung Cancer Cells JF - LETTERS IN DRUG DESIGN AND DISCOVERY J2 - LETT DRUG DES DISCOV VL - 8 PY - 2011 IS - 8 SP - 691 EP - 697 PG - 7 SN - 1570-1808 DO - 10.2174/157018011796575971 UR - https://m2.mtmt.hu/api/publication/1876459 ID - 1876459 LA - English DB - MTMT ER - TY - JOUR AU - Machado, L AU - Spengler, Gabriella AU - Evaristo, M AU - Handzlik, J AU - Molnár, József AU - Viveiros, M AU - Kiec-Kononowicz, K AU - Amaral, L TI - Biological Activity of Twenty-three Hydantoin Derivatives on Intrinsic Efflux Pump System of Salmonella enterica serovar Enteritidis NCTC 13349 JF - IN VIVO J2 - IN VIVO VL - 25 PY - 2011 IS - 5 SP - 769 EP - 772 PG - 4 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/1822629 ID - 1822629 N1 - Megjegyzés-22241904 Chemicals/CAS: ethidium bromide, 1239-45-8; Anti-Bacterial Agents; Bacterial Proteins; Ethidium, 3546-21-2; Fluorescent Dyes; Hydantoins; Membrane Transport Proteins LA - English DB - MTMT ER - TY - JOUR AU - Martins, Ana AU - Machado, L AU - Costa, S AU - Cerca, P AU - Spengler, Gabriella AU - Viveiros, M AU - Amaral, L TI - Role of calcium in the efflux system of Escherichia coli JF - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS J2 - INT J ANTIMICROB AG VL - 37 PY - 2011 IS - 5 SP - 410 EP - 414 PG - 5 SN - 0924-8579 DO - 10.1016/j.ijantimicag.2011.01.010 UR - https://m2.mtmt.hu/api/publication/1822631 ID - 1822631 N1 - Megjegyzés-22237173 Z9: 5 Megjegyzés-22287065 Chemicals/CAS: adenosine triphosphatase, 37289-25-1, 9000-83-3; calcium ion, 14127-61-8; chlorpromazine, 50-53-3, 69-09-0; edetic acid, 150-43-6, 60-00-4; ethidium bromide, 1239-45-8; proton, 12408-02-5, 12586-59-3; Anti-Bacterial Agents; Calcium, 7440-70-2; Chlorpromazine, 50-53-3; Culture Media; Edetic Acid, 60-00-4; Ethidium, 3546-21-2; Intercalating Agents Megjegyzés-22237456 Chemicals/CAS: adenosine triphosphatase, 37289-25-1, 9000-83-3; calcium ion, 14127-61-8; chlorpromazine, 50-53-3, 69-09-0; edetic acid, 150-43-6, 60-00-4; ethidium bromide, 1239-45-8; proton, 12408-02-5, 12586-59-3; Anti-Bacterial Agents; Calcium, 7440-70-2; Chlorpromazine, 50-53-3; Culture Media; Edetic Acid, 60-00-4; Ethidium, 3546-21-2; Intercalating Agents Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-008 Lisbon, Portugal UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349-008 Lisbon, Portugal COST Action BM0701 (ATENS) of the European Commission/ESF, Brussels, Belgium Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary Cited By :36 Export Date: 3 June 2021 CODEN: IAAGE Correspondence Address: Amaral, L.; Unit of Mycobacteriology, Rua da Junqueira 96, 1349-008 Lisbon, Portugal; email: lamaral@ihmt.unl.pt LA - English DB - MTMT ER - TY - JOUR AU - Ramalhete, C AU - Spengler, Gabriella AU - Martins, Ana AU - Martins, M AU - Viveiros, M AU - Mulhovo, S AU - Ferreira, MJU AU - Amaral, L TI - Inhibition of efflux pumps in meticillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina JF - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS J2 - INT J ANTIMICROB AG VL - 37 PY - 2011 IS - 1 SP - 70 EP - 74 PG - 5 SN - 0924-8579 DO - 10.1016/j.ijantimicag.2010.09.011 UR - https://m2.mtmt.hu/api/publication/1822633 ID - 1822633 N1 - Megjegyzés-22237116 Z9: 1 Megjegyzés-22263911 Z9: 1 Megjegyzés-22237070 Chemicals/CAS: ethidium bromide, 1239-45-8; Bacterial Proteins; Enzyme Inhibitors; Ethidium, 3546-21-2; Membrane Transport Proteins; Triterpenes Megjegyzés-22241902 Chemicals/CAS: ethidium bromide, 1239-45-8; Bacterial Proteins; Enzyme Inhibitors; Ethidium, 3546-21-2; Membrane Transport Proteins; Triterpenes Megjegyzés-22233771 Chemicals/CAS: ethidium bromide, 1239-45-8; Bacterial Proteins; Enzyme Inhibitors; Ethidium, 3546-21-2; Membrane Transport Proteins; Triterpenes LA - English DB - MTMT ER - TY - GEN AU - Spengler, Gabriella AU - Molnár, József AU - Serly, Julianna AU - Engi, H AU - Hohmann, Judit AU - Gang, G AU - Ferreira, MJU AU - Dumache, R AU - Pusztai, Rozália TI - Potential cancer chemopreventive agents isolated from medicinal herbs. PY - 2011 UR - https://m2.mtmt.hu/api/publication/3375000 ID - 3375000 N1 - előadás LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Molnár, József AU - Serly, Julianna AU - Engi, H AU - Hohmann, Judit AU - Gang, G AU - Ferreira, MJU AU - Dumache, R AU - Pusztai, Rozália TI - Potential cancer chemopreventive agents isolated from medical herbs JF - FIZIOLOGIA J2 - FIZIOLOGIA VL - Suppl. PY - 2011 SP - 28 SN - 1223-2076 UR - https://m2.mtmt.hu/api/publication/2405989 ID - 2405989 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Handzlik, J AU - Ocsovszki, Imre AU - Viveiros, M AU - Kiec-Kononowicz, K AU - Molnár, József AU - Amaral, L TI - Modulation of Multidrug Efflux Pump Activity by New Hydantoin Derivatives on Colon Adenocarcinoma Cells without Inducing Apoptosis JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 31 PY - 2011 IS - 10 SP - 3285 EP - 3288 PG - 4 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822628 ID - 1822628 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Molnár, József AU - Viveiros, M AU - Amaral, L TI - Thioridazine Induces Apoptosis of Multidrug-resistant Mouse Lymphoma Cells Transfected with the Human ABCB1 and Inhibits the Expression of P-Glycoprotein JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 31 PY - 2011 IS - 12 SP - 4201 EP - 4205 PG - 5 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822627 ID - 1822627 N1 - Megjegyzés-22307158 Chemicals/CAS: ethidium bromide, 1239-45-8; thioridazine, 130-61-0, 50-52-2; ABCB1 protein, human; Dopamine Antagonists; P-Glycoprotein; Thioridazine, 50-52-2 Manufacturers: Sigma Aldrich, Spain Megjegyzés-22241900 Chemicals/CAS: ethidium bromide, 1239-45-8; thioridazine, 130-61-0, 50-52-2; ABCB1 protein, human; Dopamine Antagonists; P-Glycoprotein; Thioridazine, 50-52-2 Manufacturers: Sigma Aldrich, Spain LA - English DB - MTMT ER - TY - JOUR AU - Yasui, H AU - Maoka, T AU - Molnár, József AU - Vincze, I AU - Molnár, Péter AU - Deli, József AU - Spengler, Gabriella AU - Zalatnai, A TI - Quenching effect on singlet oxygen, suppression against generation of reactive oxygen species and melanin synthesis in skin, and inhibition of multidrug resistance in cancer cells by capsorubin and capsanthin JF - ACTA BIOLOGICA CRACOVIENSIA SERIES BOTANICA J2 - ACTA BIOL CRACOV BOT VL - 53 PY - 2011 IS - S1 SP - 71 SN - 0001-5296 UR - https://m2.mtmt.hu/api/publication/1714772 ID - 1714772 LA - English DB - MTMT ER - TY - CHAP AU - Amaral, L AU - Fanning, S AU - McCusker, M AU - Spengler, Gabriella AU - Rodrigues, L AU - Iversen, C AU - Martins, M AU - Martins, A AU - Viveiros, M AU - Couto, I ED - Meszaros, A ED - Balogh, G TI - Genetic Regulation, Physiology, Assessment and Inhibition of Efflux Pumps Responsible for Multi-Drug Resistant Phenotypes of Bacterial Pathogens T2 - MULTIPLE DRUG RESISTANCE T3 - Pharmacology Research Safety Testing and Regulation PB - Nova Science Publishers PY - 2010 SP - 225 EP - 244 PG - 20 UR - https://m2.mtmt.hu/api/publication/22840041 ID - 22840041 N1 - Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira, 96, Lisboa, 1349-008, Portugal UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira, 96, Lisboa, 1349-008, Portugal COST ACTION BM0701 (ATENS) of the European Commission/ European Science Foundation, Belgium Centres for Food Safety and Food-borne Zoonomics, UCD Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, 2829-516, Portugal Transporteurs Membranaires, Chimiorésistance et Drug-Design, Facultés de Médecine et de Pharmacie, UMR-MD1, France Export Date: 10 February 2021 Correspondence Address: Amaral, L.; Unit of Mycobacteriology, Rua da Junqueira, 96, Portugal; email: lamaral@ihmt.unl.pt Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira, 96, Lisboa, 1349-008, Portugal UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira, 96, Lisboa, 1349-008, Portugal COST ACTION BM0701 (ATENS) of the European Commission/ European Science Foundation, Belgium Centres for Food Safety and Food-borne Zoonomics, UCD Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, 2829-516, Portugal Transporteurs Membranaires, Chimiorésistance et Drug-Design, Facultés de Médecine et de Pharmacie, UMR-MD1, France Export Date: 3 June 2021 Correspondence Address: Amaral, L.; Unit of Mycobacteriology, Rua da Junqueira, 96, Portugal; email: lamaral@ihmt.unl.pt LA - English DB - MTMT ER - TY - JOUR AU - Amaral, L AU - Martins, Ana AU - Molnár, József AU - Kristiansen, JE AU - Martins, M AU - Viveiros, M AU - Rodrigues, L AU - Spengler, Gabriella AU - Couto, I AU - Ramos, J AU - Dastidar, S AU - Fanning, S AU - Mccusker, M AU - Pages, JM TI - Phenothiazines, Bacterial Efflux Pumps and Targeting the Macrophage for Enhanced Killing of Intracellular XDRTB JF - IN VIVO J2 - IN VIVO VL - 24 PY - 2010 IS - 4 SP - 409 EP - 424 PG - 16 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/1822635 ID - 1822635 N1 - Megjegyzés-22237500 Z9: 3 Megjegyzés-22241906 Chemicals/CAS: chloramphenicol, 134-90-7, 2787-09-9, 56-75-7; chlorpromazine, 50-53-3, 69-09-0; erythromycin, 114-07-8, 70536-18-4; fusidic acid, 6990-06-3; lincosamide, 80738-43-8; penicillin G, 1406-05-9, 61-33-6; pristinamycin, 11132-90-4; rifampicin, 13292-46-1; sulfadiazine, 547-32-0, 68-35-9; Antipsychotic Agents; Antitubercular Agents; Chlorpromazine, 50-53-3; Phenothiazines Megjegyzés-22257260 Chemicals/CAS: chloramphenicol, 134-90-7, 2787-09-9, 56-75-7; chlorpromazine, 50-53-3, 69-09-0; erythromycin, 114-07-8, 70536-18-4; fusidic acid, 6990-06-3; lincosamide, 80738-43-8; penicillin G, 1406-05-9, 61-33-6; pristinamycin, 11132-90-4; rifampicin, 13292-46-1; sulfadiazine, 547-32-0, 68-35-9; Antipsychotic Agents; Antitubercular Agents; Chlorpromazine, 50-53-3; Phenothiazines Megjegyzés-22287071 Chemicals/CAS: chloramphenicol, 134-90-7, 2787-09-9, 56-75-7; chlorpromazine, 50-53-3, 69-09-0; erythromycin, 114-07-8, 70536-18-4; fusidic acid, 6990-06-3; lincosamide, 80738-43-8; penicillin G, 1406-05-9, 61-33-6; pristinamycin, 11132-90-4; rifampicin, 13292-46-1; sulfadiazine, 547-32-0, 68-35-9; Antipsychotic Agents; Antitubercular Agents; Chlorpromazine, 50-53-3; Phenothiazines Megjegyzés-22307067 Chemicals/CAS: chloramphenicol, 134-90-7, 2787-09-9, 56-75-7; chlorpromazine, 50-53-3, 69-09-0; erythromycin, 114-07-8, 70536-18-4; fusidic acid, 6990-06-3; lincosamide, 80738-43-8; penicillin G, 1406-05-9, 61-33-6; pristinamycin, 11132-90-4; rifampicin, 13292-46-1; sulfadiazine, 547-32-0, 68-35-9; Antipsychotic Agents; Antitubercular Agents; Chlorpromazine, 50-53-3; Phenothiazines Megjegyzés-23086671 N1 : Chemicals/CASchloramphenicol, 134-90-7, 2787-09-9, 56-75-7; chlorpromazine, 50-53-3, 69-09-0; erythromycin, 114-07-8, 70536-18-4; fusidic acid, 6990-06-3; lincosamide, 80738-43-8; penicillin G, 1406-05-9, 61-33-6; pristinamycin, 11132-90-4; rifampicin, 13292-46-1; sulfadiazine, 547-32-0, 68-35-9; Antipsychotic Agents; Antitubercular Agents; Chlorpromazine, 50-53-3; Phenothiazines Megjegyzés-22237463 Chemicals/CAS: chloramphenicol, 134-90-7, 2787-09-9, 56-75-7; chlorpromazine, 50-53-3, 69-09-0; erythromycin, 114-07-8, 70536-18-4; fusidic acid, 6990-06-3; lincosamide, 80738-43-8; penicillin G, 1406-05-9, 61-33-6; pristinamycin, 11132-90-4; rifampicin, 13292-46-1; sulfadiazine, 547-32-0, 68-35-9; Antipsychotic Agents; Antitubercular Agents; Chlorpromazine, 50-53-3; Phenothiazines Unit of Mycobacteriology, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Rua Junqueira 96, 1349-008 Lisbon, Portugal UPMM, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, Portugal COST ACTION BM0701 (ATENS), University of Szeged, Szeged, Hungary Institute of Medical Microbiology and Immunology, University of Szeged, Szeged, Hungary Department of Clinical Microbiology, Southern Danish University, Sonderborg, Denmark Centro de Recursos Microbiológicos, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisbon, Portugal Department of Microbiology, Herbicure Healthcare Bioherbal Research Foundation, Kolkata, India Centre for Food Safety, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin, Ireland UMR-MD-1, Facultés de Médecine et de Pharmacie, Université de la Méditerranée, Marseille, France Cited By :41 Export Date: 3 June 2021 CODEN: IVIVE Correspondence Address: Amaral, L.; Unit of Mycobacteriology, Rua Junqueira 96, 1349-008 Lisbon, Portugal; email: lamaral@ihmt.unl.pt LA - English DB - MTMT ER - TY - JOUR AU - Martins, Ana AU - Spengler, Gabriella AU - Martins, M AU - Rodrigues, L AU - Viveiros, M AU - Davin-Regli, A AU - Chevalier, J AU - Couto, I AU - Pages, JM AU - Amaral, L TI - Physiological characterisation of the efflux pump system of antibiotic-susceptible and multidrug-resistant Enterobacter aerogenes JF - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS J2 - INT J ANTIMICROB AG VL - 36 PY - 2010 IS - 4 SP - 313 EP - 318 PG - 6 SN - 0924-8579 DO - 10.1016/j.ijantimicag.2010.06.036 UR - https://m2.mtmt.hu/api/publication/1822634 ID - 1822634 N1 - Megjegyzés-22257259 Chemicals/CAS: carrier protein, 80700-39-6; cefepime, 88040-23-7; ceftazidime, 72558-82-8; chloramphenicol, 134-90-7, 2787-09-9, 56-75-7; ciprofloxacin, 85721-33-1; erythromycin, 114-07-8, 70536-18-4; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; glucose, 50-99-7, 84778-64-3; imipenem, 64221-86-9; nalidixic acid, 389-08-2; norfloxacin, 70458-96-7; ofloxacin, 82419-36-1; sparfloxacin, 111542-93-9; tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; ATP-Binding Cassette Transporters; Anti-Bacterial Agents; Bacterial Proteins; Ethidium, 3546-21-2; Glucose, 50-99-7 Megjegyzés-22242893 Chemicals/CAS: carrier protein, 80700-39-6; cefepime, 88040-23-7; ceftazidime, 72558-82-8; chloramphenicol, 134-90-7, 2787-09-9, 56-75-7; ciprofloxacin, 85721-33-1; erythromycin, 114-07-8, 70536-18-4; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; glucose, 50-99-7, 84778-64-3; imipenem, 64221-86-9; nalidixic acid, 389-08-2; norfloxacin, 70458-96-7; ofloxacin, 82419-36-1; sparfloxacin, 111542-93-9; tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; ATP-Binding Cassette Transporters; Anti-Bacterial Agents; Bacterial Proteins; Ethidium, 3546-21-2; Glucose, 50-99-7 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Evaristo, M AU - Handzlik, J AU - Serly, Julianna AU - Molnár, József AU - Viveiros, M AU - Kiec-Kononowicz, K AU - Amaral, L TI - Biological Activity of Hydantoin Derivatives on P-Glycoprotein (ABCB1) of Mouse Lymphoma Cells JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 30 PY - 2010 IS - 12 SP - 4867 EP - 4871 PG - 5 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822632 ID - 1822632 N1 - Megjegyzés-22244146 Z9: 3 LA - English DB - MTMT ER - TY - JOUR AU - Viveiros, M AU - Rodrigues, L AU - Martins, M AU - Couto, I AU - Spengler, Gabriella AU - Martins, Ana AU - Amaral, L TI - Evaluation of efflux activity of bacteria by a semi-automated fluorometric system. JF - METHODS IN MOLECULAR BIOLOGY J2 - METHODS MOL BIOL VL - 642 PY - 2010 SP - 159 EP - 172 PG - 14 SN - 1064-3745 DO - 10.1007/978-1-60327-279-7_12 UR - https://m2.mtmt.hu/api/publication/2442619 ID - 2442619 N1 - Megjegyzés-22840042 BE McHugh, TD Admin megjegyzés-22840042 10.1007/978-1-60327-279-7 AB - A semi-automated method that uses the common efflux pump (EP) substrate ethidium bromide (EB) is described for the assessment of EP systems of bacteria. The method employs the Rotor-Gene(TM) 3000 thermocycler (Corbett Research) for the real-time assessment of accumulation and efflux of EB in Phosphate-Buffered Solution (PBS) under varying physiological conditions, such as temperature, pH, presence and absence of the energy source, and presence of efflux pumps inhibitors (EPIs). The method is sufficiently sensitive to characterize intrinsic EP systems of reference strains, a prime necessity if there is a need for assessment of EP-mediated multi-drug resistance (MDR). The method has been successfully applied by us to characterize intrinsic and over-expressed EP systems of Escherichia coli, Salmonella Enteritidis, Enterobacter aerogenes, Enterococcus faecalis and Enterococcus faecium, Staphylococcus aureus, and Mycobacterium smegmatis and Mycobacterium avium, suggesting that if the organism can be maintained in PBS, the system described may suffice for the evaluation and assessment of its EP system. LA - English DB - MTMT ER - TY - CHAP AU - Amaral, L AU - Fanning, S AU - Spengler, Gabriella AU - Rodrigues, L AU - Iversen, C AU - Martins, M AU - Martins, Ana AU - Viveiros, M AU - Couto, I ED - Adriel, R Bonilla ED - Kaden, P Muniz TI - Genetic Regulation, Physiology, Assessment and Inhibition of Efflux Pumps Responsible for Multi-Drug Resistant Phenotypes of Bacterial Pathogens T2 - Antibiotic Resistance: Causes and Risk Factors, Mechanisms and Alternatives PB - Nova Science Publishers CY - Hauppauge, New York SN - 9781607416234 PY - 2009 SP - 313 EP - 332 PG - 20 UR - https://m2.mtmt.hu/api/publication/2445850 ID - 2445850 N1 - Unit of Mycobacteriology, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 96, 1349-008 Lisboa, Portugal UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 96, 1349-008 Lisboa, Portugal COST ACTION BM0701 (ATENS) of the European Commission, European Science Foundation, France Centres for Food Safety and Food-borne Zoonomics, UCD Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland Centro de Recursos Microbiológicos (CREM), Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal Cited By :3 Export Date: 10 February 2021 Correspondence Address: Amaral, L.; Unit of Mycobacteriology, Rua da Junqueira 96, 1349-008 Lisboa, Portugal; email: lamaral@ihmt.unl.pt Unit of Mycobacteriology, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 96, 1349-008 Lisboa, Portugal UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira 96, 1349-008 Lisboa, Portugal COST ACTION BM0701 (ATENS) of the European Commission, European Science Foundation, France Centres for Food Safety and Food-borne Zoonomics, UCD Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Ireland Centro de Recursos Microbiológicos (CREM), Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal Cited By :3 Export Date: 3 June 2021 Correspondence Address: Amaral, L.; Unit of Mycobacteriology, Rua da Junqueira 96, 1349-008 Lisboa, Portugal; email: lamaral@ihmt.unl.pt LA - English DB - MTMT ER - TY - JOUR AU - Martins, Ana AU - Iversen, C AU - Rodrigues, L AU - Spengler, Gabriella AU - Ramos, J AU - Kern, WV AU - Couto, I AU - Viveiros, M AU - Fanning, S AU - Pages, JM AU - Amaral, L TI - An AcrAB-mediated multidrug-resistant phenotype is maintained following restoration of wild-type activities by efflux pump genes and their regulators JF - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS J2 - INT J ANTIMICROB AG VL - 34 PY - 2009 IS - 6 SP - 602 EP - 604 PG - 3 SN - 0924-8579 DO - 10.1016/j.ijantimicag.2009.06.029 UR - https://m2.mtmt.hu/api/publication/1822637 ID - 1822637 N1 - Megjegyzés-22257269 Chemicals/CAS: antibiotic g 418, 49863-47-0, 83855-92-9; cefalotin, 153-61-7, 58-71-9; cefazolin, 25953-19-9, 27164-46-1; cefoperazone, 62893-19-0, 62893-20-3; cefotaxime, 63527-52-6, 64485-93-4; cefuroxime, 55268-75-2, 56238-63-2; chlortetracycline, 12691-62-2, 57-62-5, 64-72-2, 78794-02-2; cinoxacin, 28657-80-9; ciprofloxacin, 85721-33-1; demeclocycline, 127-33-3, 64-73-3; doxycycline, 10592-13-9, 17086-28-1, 564-25-0; enoxacin, 74011-58-8; kanamycin, 11025-66-4, 61230-38-4, 8063-07-8; lomefloxacin, 98079-51-7; nalidixic acid, 389-08-2; norfloxacin, 70458-96-7; ofloxacin, 82419-36-1; oxolinic acid, 14698-29-4; oxytetracycline, 2058-46-0, 56761-42-3, 79-57-2; pipemidic acid, 51940-44-4; rolitetracycline, 751-97-3; sisomicin, 32385-11-8; tetracycline, 23843-90-5, 60-54-8, 64-75-5; tobramycin, 32986-56-4; AcrA protein, E coli; AcrE protein, E coli; Anti-Bacterial Agents; Escherichia coli Proteins; Lipoproteins; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Quinolones; Tetracycline, 60-54-8; beta-Lactams Tradenames: g 418; geneticin LA - English DB - MTMT ER - TY - JOUR AU - Martins, Ana AU - Spengler, Gabriella AU - Rodrigues, L AU - Viveiros, M AU - Ramos, J AU - Martins, M AU - Couto, I AU - Fanning, S AU - Pages, JM AU - Bolla, JM AU - Molnár, József AU - Amaral, L TI - pH Modulation of Efflux Pump Activity of Multi-Drug Resistant Escherichia coli. Protection During Its Passage and Eventual Colonization of the Colon TS - Protection During Its Passage and Eventual Colonization of the Colon JF - PLOS ONE J2 - PLOS ONE VL - 4 PY - 2009 IS - 8 PG - 9 SN - 1932-6203 DO - 10.1371/journal.pone.0006656 UR - https://m2.mtmt.hu/api/publication/1822636 ID - 1822636 N1 - Megjegyzés-22257265 Chemicals/CAS: carrier protein, 80700-39-6; ethidium bromide, 1239-45-8; glucose, 50-99-7, 84778-64-3; tetracycline, 23843-90-5, 60-54-8, 64-75-5 Megjegyzés-22242895 Chemicals/CAS: carrier protein, 80700-39-6; ethidium bromide, 1239-45-8; glucose, 50-99-7, 84778-64-3; tetracycline, 23843-90-5, 60-54-8, 64-75-5 LA - English DB - MTMT ER - TY - JOUR AU - Ramalhete, C AU - Spengler, Gabriella AU - Serly, Julianna AU - Amaral, L AU - Molnár, József AU - Mulhovo, S AU - Ferreira, MJU TI - Efflux modulators from Momordica balsamina L. in multidrug resistant bacterial strains JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 75 PY - 2009 IS - 9 SP - 896 EP - 896 PG - 1 SN - 0032-0943 UR - https://m2.mtmt.hu/api/publication/1822639 ID - 1822639 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Martins, Ana AU - Schelz, Zsuzsanna AU - Rodrigues, L AU - Aagaard, L AU - Martins, M AU - Costa, SS AU - Couto, I AU - Viveiros, M AU - Fanning, S AU - Kristiansen, JE AU - Molnár, József AU - Amaral, L TI - Characterization of Intrinsic Efflux Activity of Enterococcus faecalis ATCC29212 by a Semi-automated Ethidium Bromide Method JF - IN VIVO J2 - IN VIVO VL - 23 PY - 2009 IS - 1 SP - 81 EP - 87 PG - 7 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/1822641 ID - 1822641 N1 - Megjegyzés-22243991 Chemicals/CAS: carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; ethidium bromide, 1239-45-8; proton, 12408-02-5, 12586-59-3; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; Carbonyl Cyanide m-Chlorophenyl Hydrazone, 555-60-2; Ethidium, 3546-21-2; Glucose, 50-99-7; Membrane Transport Proteins; Reserpine, 50-55-5; Thioridazine, 50-52-2; Uncoupling Agents Megjegyzés-22241910 Chemicals/CAS: carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; ethidium bromide, 1239-45-8; proton, 12408-02-5, 12586-59-3; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; Carbonyl Cyanide m-Chlorophenyl Hydrazone, 555-60-2; Ethidium, 3546-21-2; Glucose, 50-99-7; Membrane Transport Proteins; Reserpine, 50-55-5; Thioridazine, 50-52-2; Uncoupling Agents LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Viveiros, M AU - Martins, M AU - Rodrigues, L AU - Martins, Ana AU - Molnár, József AU - Couto, I AU - Amaral, L TI - Demonstration of the Activity of P-glycoprotein by a Semi-automated Fluorometric Method JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 29 PY - 2009 IS - 6 SP - 2173 EP - 2177 PG - 5 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822640 ID - 1822640 N1 - Megjegyzés-22271770 Z9: 8 Megjegyzés-21982318 Chemicals/CAS: ethidium bromide, 1239-45-8; reserpine, 50-55-5, 8001-95-4; verapamil, 152-11-4, 52-53-9; ABCB1 protein, human; Adrenergic Uptake Inhibitors; Calcium Channel Blockers; Ethidium, 3546-21-2; P-Glycoprotein; Reserpine, 50-55-5; Verapamil, 52-53-9 Megjegyzés-22307163 Chemicals/CAS: ethidium bromide, 1239-45-8; reserpine, 50-55-5, 8001-95-4; verapamil, 152-11-4, 52-53-9; ABCB1 protein, human; Adrenergic Uptake Inhibitors; Calcium Channel Blockers; Ethidium, 3546-21-2; P-Glycoprotein; Reserpine, 50-55-5; Verapamil, 52-53-9 Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), 1349-008 Lisboa, Portugal UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), 1349-008 Lisboa, Portugal Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, UNL, 2829-516 Caparica, Portugal Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary COST ACTION BM0701 (ATENS) Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira, 96, 1349-008 Lisboa, Portugal Cited By :17 Export Date: 8 February 2020 CODEN: ANTRD Correspondence Address: Amaral, L.; Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira, 96, 1349-008 Lisboa, Portugal; email: lamaral@ihmt.unl.pt Chemicals/CAS: ethidium bromide, 1239-45-8; reserpine, 50-55-5, 8001-95-4; verapamil, 152-11-4, 52-53-9; ABCB1 protein, human; Adrenergic Uptake Inhibitors; Calcium Channel Blockers; Ethidium, 3546-21-2; P-Glycoprotein; Reserpine, 50-55-5; Verapamil, 52-53-9 Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), 1349-008 Lisboa, Portugal UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), 1349-008 Lisboa, Portugal Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, UNL, 2829-516 Caparica, Portugal Institute of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary COST ACTION BM0701 (ATENS) Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira, 96, 1349-008 Lisboa, Portugal Cited By :19 Export Date: 19 January 2021 CODEN: ANTRD Correspondence Address: Amaral, L.; Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa (IHMT/UNL), Rua da Junqueira, 96, 1349-008 Lisboa, Portugal; email: lamaral@ihmt.unl.pt Chemicals/CAS: ethidium bromide, 1239-45-8; reserpine, 50-55-5, 8001-95-4; verapamil, 152-11-4, 52-53-9; ABCB1 protein, human; Adrenergic Uptake Inhibitors; Calcium Channel Blockers; Ethidium, 3546-21-2; P-Glycoprotein; Reserpine, 50-55-5; Verapamil, 52-53-9 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Ramalhete, C AU - Martins, M AU - Martins, Ana AU - Serly, Julianna AU - Viveiros, M AU - Molnár, József AU - Duarte, N AU - Mulhovo, S AU - Ferreira, MJU AU - Amaral, L TI - Evaluation of Cucurbitane-type Triterpenoids from Momordica balsamina on P-Glycoprotein (ABCB1) by Flow Cytometry and Real-time Fluorometry JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 29 PY - 2009 IS - 10 SP - 3989 EP - 3993 PG - 5 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822638 ID - 1822638 N1 - Megjegyzés-22237076 Chemicals/CAS: dimethyl sulfoxide, 67-68-5; ethidium bromide, 1239-45-8; rhodamine 123, 62669-70-9; verapamil, 152-11-4, 52-53-9; Glycosides; P-Glycoprotein; Terpenes; Triterpenes; cucurbitane Megjegyzés-20999857 Chemicals/CAS: dimethyl sulfoxide, 67-68-5; ethidium bromide, 1239-45-8; rhodamine 123, 62669-70-9; verapamil, 152-11-4, 52-53-9 LA - English DB - MTMT ER - TY - JOUR AU - Amaral, L AU - Spengler, Gabriella AU - Viveiros, M AU - Rodrigues, L AU - Martins, Ana AU - Couto, I AU - Martins, M AU - Fanning, S AU - Pages, JM AU - Molnár, József TI - ASSESSMENT AND COMPARISON OF EFFLUX PUMPS OF CANCER CELLS AND MDR BACTERIA UNDER PHYSIOLOGICAL CONDITIONS BY A REAL-TIME SEMI-AUTOMATED SYSTEM JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 28 PY - 2008 IS - 5C SP - 3193 EP - 3194 PG - 2 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822642 ID - 1822642 N1 - WoS:hiba:000260555300019 2019-03-04 01:19 cikkazonosító nem egyezik LA - English DB - MTMT ER - TY - JOUR AU - Martins, Ana AU - Vasas, Andrea AU - Schelz, Zsuzsanna AU - Viveiros, M AU - Molnár, József AU - Hohmann, Judit AU - Spengler, Gabriella AU - Amaral, L TI - CONSTITUENTS OF CARPOBROTUS EDULIS INHIBIT P-GLYCOPROTEIN OF HUMAN MDR1 GENE TRANSFECTED MOUSE LYMPHOMA CELLS JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 28 PY - 2008 IS - 5C SP - 3397 EP - 3397 PG - 1 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822643 ID - 1822643 N1 - : Leonard/I-2112-2012 WoS:hiba:000260555300439 2019-03-04 01:19 cikkazonosító nem egyezik LA - English DB - MTMT ER - TY - JOUR AU - Martins, M AU - Dastidar, SG AU - Fanning, S AU - Kristiansen, JE AU - Molnár, József AU - Pages, JM AU - Schelz, Zsuzsanna AU - Spengler, Gabriella AU - Viveiros, M AU - Amaral, L TI - Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities JF - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS J2 - INT J ANTIMICROB AG VL - 31 PY - 2008 IS - 3 SP - 198 EP - 208 PG - 11 SN - 0924-8579 DO - 10.1016/j.ijantimicag.2007.10.025 UR - https://m2.mtmt.hu/api/publication/1822646 ID - 1822646 N1 - Megjegyzés-22063855 DI: 10.1016/j.ijantimicag.2007.10.025 Megjegyzés-22237511 Z9: 34 Megjegyzés-21006145 PubMed ID: 18180147 Chemicals/CAS: alimemazine, 84-96-8; amlodipine, 88150-42-9; bromodiphenhydramine, 118-23-0, 1808-12-4; carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; chlorpromazine, 50-53-3, 69-09-0; diclofenac, 15307-79-6, 15307-86-5; dicycloverine, 50815-09-3, 67-92-5, 77-19-0; diphenhydramine, 147-24-0, 58-73-1; dobutamine, 34368-04-2, 52663-81-7; flupentixol, 2413-38-9, 2709-56-0; fluphenazine, 146-56-5, 69-23-8; lacidipine, 103890-78-4; methdilazine, 1229-35-2, 1982-37-2; methyldopa, 555-29-3, 555-30-6; nifedipine, 21829-25-4; oxyfedrine, 15687-41-9, 16777-42-7; prochlorperazine, 58-38-8; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; trifluoperazine, 117-89-5, 440-17-5; triflupromazine, 1098-60-8, 146-54-3; Anti-Bacterial Agents; Enzyme Inhibitors Megjegyzés-22238145 Chemicals/CAS: alimemazine, 84-96-8; amlodipine, 88150-42-9; bromodiphenhydramine, 118-23-0, 1808-12-4; carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; chlorpromazine, 50-53-3, 69-09-0; diclofenac, 15307-79-6, 15307-86-5; dicycloverine, 50815-09-3, 67-92-5, 77-19-0; diphenhydramine, 147-24-0, 58-73-1; dobutamine, 34368-04-2, 52663-81-7; flupentixol, 2413-38-9, 2709-56-0; fluphenazine, 146-56-5, 69-23-8; lacidipine, 103890-78-4; methdilazine, 1229-35-2, 1982-37-2; methyldopa, 555-29-3, 555-30-6; nifedipine, 21829-25-4; oxyfedrine, 15687-41-9, 16777-42-7; prochlorperazine, 58-38-8; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; trifluoperazine, 117-89-5, 440-17-5; triflupromazine, 1098-60-8, 146-54-3; Anti-Bacterial Agents; Enzyme Inhibitors Megjegyzés-22242880 Chemicals/CAS: alimemazine, 84-96-8; amlodipine, 88150-42-9; bromodiphenhydramine, 118-23-0, 1808-12-4; carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; chlorpromazine, 50-53-3, 69-09-0; diclofenac, 15307-79-6, 15307-86-5; dicycloverine, 50815-09-3, 67-92-5, 77-19-0; diphenhydramine, 147-24-0, 58-73-1; dobutamine, 34368-04-2, 52663-81-7; flupentixol, 2413-38-9, 2709-56-0; fluphenazine, 146-56-5, 69-23-8; lacidipine, 103890-78-4; methdilazine, 1229-35-2, 1982-37-2; methyldopa, 555-29-3, 555-30-6; nifedipine, 21829-25-4; oxyfedrine, 15687-41-9, 16777-42-7; prochlorperazine, 58-38-8; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; trifluoperazine, 117-89-5, 440-17-5; triflupromazine, 1098-60-8, 146-54-3; Anti-Bacterial Agents; Enzyme Inhibitors Megjegyzés-22243992 Chemicals/CAS: alimemazine, 84-96-8; amlodipine, 88150-42-9; bromodiphenhydramine, 118-23-0, 1808-12-4; carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; chlorpromazine, 50-53-3, 69-09-0; diclofenac, 15307-79-6, 15307-86-5; dicycloverine, 50815-09-3, 67-92-5, 77-19-0; diphenhydramine, 147-24-0, 58-73-1; dobutamine, 34368-04-2, 52663-81-7; flupentixol, 2413-38-9, 2709-56-0; fluphenazine, 146-56-5, 69-23-8; lacidipine, 103890-78-4; methdilazine, 1229-35-2, 1982-37-2; methyldopa, 555-29-3, 555-30-6; nifedipine, 21829-25-4; oxyfedrine, 15687-41-9, 16777-42-7; prochlorperazine, 58-38-8; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; trifluoperazine, 117-89-5, 440-17-5; triflupromazine, 1098-60-8, 146-54-3; Anti-Bacterial Agents; Enzyme Inhibitors Megjegyzés-22257270 Chemicals/CAS: alimemazine, 84-96-8; amlodipine, 88150-42-9; bromodiphenhydramine, 118-23-0, 1808-12-4; carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; chlorpromazine, 50-53-3, 69-09-0; diclofenac, 15307-79-6, 15307-86-5; dicycloverine, 50815-09-3, 67-92-5, 77-19-0; diphenhydramine, 147-24-0, 58-73-1; dobutamine, 34368-04-2, 52663-81-7; flupentixol, 2413-38-9, 2709-56-0; fluphenazine, 146-56-5, 69-23-8; lacidipine, 103890-78-4; methdilazine, 1229-35-2, 1982-37-2; methyldopa, 555-29-3, 555-30-6; nifedipine, 21829-25-4; oxyfedrine, 15687-41-9, 16777-42-7; prochlorperazine, 58-38-8; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; trifluoperazine, 117-89-5, 440-17-5; triflupromazine, 1098-60-8, 146-54-3; Anti-Bacterial Agents; Enzyme Inhibitors Megjegyzés-22287081 Chemicals/CAS: alimemazine, 84-96-8; amlodipine, 88150-42-9; bromodiphenhydramine, 118-23-0, 1808-12-4; carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; chlorpromazine, 50-53-3, 69-09-0; diclofenac, 15307-79-6, 15307-86-5; dicycloverine, 50815-09-3, 67-92-5, 77-19-0; diphenhydramine, 147-24-0, 58-73-1; dobutamine, 34368-04-2, 52663-81-7; flupentixol, 2413-38-9, 2709-56-0; fluphenazine, 146-56-5, 69-23-8; lacidipine, 103890-78-4; methdilazine, 1229-35-2, 1982-37-2; methyldopa, 555-29-3, 555-30-6; nifedipine, 21829-25-4; oxyfedrine, 15687-41-9, 16777-42-7; prochlorperazine, 58-38-8; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; trifluoperazine, 117-89-5, 440-17-5; triflupromazine, 1098-60-8, 146-54-3; Anti-Bacterial Agents; Enzyme Inhibitors Megjegyzés-22307089 Chemicals/CAS: alimemazine, 84-96-8; amlodipine, 88150-42-9; bromodiphenhydramine, 118-23-0, 1808-12-4; carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; chlorpromazine, 50-53-3, 69-09-0; diclofenac, 15307-79-6, 15307-86-5; dicycloverine, 50815-09-3, 67-92-5, 77-19-0; diphenhydramine, 147-24-0, 58-73-1; dobutamine, 34368-04-2, 52663-81-7; flupentixol, 2413-38-9, 2709-56-0; fluphenazine, 146-56-5, 69-23-8; lacidipine, 103890-78-4; methdilazine, 1229-35-2, 1982-37-2; methyldopa, 555-29-3, 555-30-6; nifedipine, 21829-25-4; oxyfedrine, 15687-41-9, 16777-42-7; prochlorperazine, 58-38-8; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; trifluoperazine, 117-89-5, 440-17-5; triflupromazine, 1098-60-8, 146-54-3; Anti-Bacterial Agents; Enzyme Inhibitors Megjegyzés-23086674 N1 : Chemicals/CASalimemazine, 84-96-8; amlodipine, 88150-42-9; bromodiphenhydramine, 118-23-0, 1808-12-4; carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; chlorpromazine, 50-53-3, 69-09-0; diclofenac, 15307-79-6, 15307-86-5; dicycloverine, 50815-09-3, 67-92-5, 77-19-0; diphenhydramine, 147-24-0, 58-73-1; dobutamine, 34368-04-2, 52663-81-7; flupentixol, 2413-38-9, 2709-56-0; fluphenazine, 146-56-5, 69-23-8; lacidipine, 103890-78-4; methdilazine, 1229-35-2, 1982-37-2; methyldopa, 555-29-3, 555-30-6; nifedipine, 21829-25-4; oxyfedrine, 15687-41-9, 16777-42-7; prochlorperazine, 58-38-8; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; reserpine, 50-55-5, 8001-95-4; thioridazine, 130-61-0, 50-52-2; trifluoperazine, 117-89-5, 440-17-5; triflupromazine, 1098-60-8, 146-54-3; Anti-Bacterial Agents; Enzyme Inhibitors LA - English DB - MTMT ER - TY - CHAP AU - Molnár, József AU - Engi, Helga AU - Gyémánt, N AU - Schelz, Zsuzsanna AU - Spengler, Gabriella AU - Ocsovszki, Imre AU - Szücs, M AU - Hohmann, Judit AU - Szabó, M AU - Tanács, Lajos AU - Molnár, Péter AU - Deli, József AU - Krenn, L AU - Kawase, M AU - Wakabayashi, H AU - Kurihara, T AU - Shirataki, Y AU - Sakagami, H AU - Motohashi, N AU - Didiziapetris, R ED - Noboru, Motohashi TI - Multidrug Resistance Reversal on Cancer Cells by Selected Carotenoids, Flavonoids and Anthocyanins T2 - Bioactive Heterocycles VI PB - Springer Netherlands CY - Berlin CY - Heidelberg T3 - Topics in Heterocyclic Chemistry ; 15. PY - 2008 SP - 133 EP - 159 PG - 27 DO - 10.1007/7081_2008_120 UR - https://m2.mtmt.hu/api/publication/1140757 ID - 1140757 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Viveiros, M AU - Martins, A AU - Rodrigues, L AU - Martins, M AU - Molnár, József AU - Couto, I AU - Amaral, L TI - DEMONSTRATION OF THE ACTIVITY OF P-GLYCOPROTEIN BY A FULLY AUTOMATED ETHIDIUM BROMIDE METHOD JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 28 PY - 2008 IS - 5C SP - 3493 EP - 3493 PG - 1 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/2756099 ID - 2756099 LA - English DB - MTMT ER - TY - JOUR AU - Viveiros, M AU - Martins, M AU - Couto, I AU - Rodrigues, L AU - Spengler, Gabriella AU - Martins, Ana AU - Kristiansen, JE AU - Molnár, József AU - Amaral, L TI - New Methods for the Identification of Efflux Mediated MDR Bacteria, Genetic Assessment of Regulators and Efflux Pump Constituents, Characterization of Efflux Systems and Screening for Inhibitors of Efflux Pumps JF - CURRENT DRUG TARGETS J2 - CURR DRUG TARGETS VL - 9 PY - 2008 IS - 9 SP - 760 EP - 778 PG - 19 SN - 1389-4501 DO - 10.2174/138945008785747734 UR - https://m2.mtmt.hu/api/publication/1822645 ID - 1822645 N1 - Megjegyzés-22242899 Chemicals/CAS: carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; carrier protein, 80700-39-6; chlorpromazine, 50-53-3, 69-09-0; tetracycline, 23843-90-5, 60-54-8, 64-75-5; thioridazine, 130-61-0, 50-52-2; Anti-Bacterial Agents; Bacterial Proteins; Membrane Transport Proteins Tradenames: mc 207110 Megjegyzés-22243993 Chemicals/CAS: carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; carrier protein, 80700-39-6; chlorpromazine, 50-53-3, 69-09-0; tetracycline, 23843-90-5, 60-54-8, 64-75-5; thioridazine, 130-61-0, 50-52-2; Anti-Bacterial Agents; Bacterial Proteins; Membrane Transport Proteins Tradenames: mc 207110 Megjegyzés-22257271 Chemicals/CAS: carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; carrier protein, 80700-39-6; chlorpromazine, 50-53-3, 69-09-0; tetracycline, 23843-90-5, 60-54-8, 64-75-5; thioridazine, 130-61-0, 50-52-2; Anti-Bacterial Agents; Bacterial Proteins; Membrane Transport Proteins Tradenames: mc 207110 Megjegyzés-22241912 Chemicals/CAS: carbonyl cyanide chlorophenylhydrazone, 32389-86-9, 555-60-2; carrier protein, 80700-39-6; chlorpromazine, 50-53-3, 69-09-0; tetracycline, 23843-90-5, 60-54-8, 64-75-5; thioridazine, 130-61-0, 50-52-2; Anti-Bacterial Agents; Bacterial Proteins; Membrane Transport Proteins Tradenames: mc 207110 Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Rua da Junqueira 96, 1349-008 Lisboa, Portugal UPMM, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Rua da Junqueira 96, 1349-008 Lisboa, Portugal Centro de Recursos Microbiológicos (CREM), Faculdade de Ciências e Tecnologia, UNL, 2829-516 Caparica, Portugal Department of Clinical Microbiology, Sønderborg Southern Danish University, Sydvang 1, 6400 Sønderborg, Denmark Department of Medical Microbiology and Immunology, Institute of Medical Microbiology, University of Szeged, Szeged, Hungary Cited By :43 Export Date: 3 June 2021 CODEN: CDTUA Correspondence Address: Amaral, L.; Unit of Mycobacteriology, Rua da Junqueira 96, 1349-008 Lisboa, Portugal; email: lamaral@ihmt.unl.pt LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella TI - Attempts to Reduce Drug Resistance of Bacteria and Cancer Cells [PhD Thesis] JF - HUNGARIAN MEDICAL JOURNAL J2 - HUNG MED J VL - 1 PY - 2007 IS - 1 SP - 109 EP - 125 PG - 17 SN - 1788-6139 DO - 10.1556/OH-HMJ.2007.28016 UR - https://m2.mtmt.hu/api/publication/3241008 ID - 3241008 N1 - PhD Thesis LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella TI - Kísérletek baktériumok és tumorsejtek gyógyszer-rezisztenciájának csökkentésére [Attempts to reduce drug resistance of bacteria and cancer cells] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 148 PY - 2007 IS - 22 SP - 1037 EP - 1040 PG - 4 SN - 0030-6002 DO - 10.1556/OH.2007.28016 UR - https://m2.mtmt.hu/api/publication/1822543 ID - 1822543 N1 - Megjegyzés-21006150 PubMed ID: 17526448 Chemicals/CAS: doxycycline, 10592-13-9, 17086-28-1, 564-25-0; promethazine, 58-33-3, 60-87-7; trifluoperazine, 117-89-5, 440-17-5; aminoacridine, 134-50-9, 27254-80-4, 90-45-9; propane, 74-98-6; 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone; Aminacrine, 90-45-9; Anti-Bacterial Agents; Antineoplastic Agents; Benzoxazoles; Promethazine, 60-87-7; Propane, 74-98-6; Proton Pumps; Trifluoperazine, 117-89-5 Megjegyzés-21140022 PubMed ID: 17526448 Chemicals/CAS: doxycycline, 10592-13-9, 17086-28-1, 564-25-0; promethazine, 58-33-3, 60-87-7; trifluoperazine, 117-89-5, 440-17-5; aminoacridine, 134-50-9, 27254-80-4, 90-45-9; propane, 74-98-6; 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone; Aminacrine, 90-45-9; Anti-Bacterial Agents; Antineoplastic Agents; Benzoxazoles; Promethazine, 60-87-7; Propane, 74-98-6; Proton Pumps; Trifluoperazine, 117-89-5 Megjegyzés-24312511 PubMed ID: 17526448 Chemicals/CAS: doxycycline, 10592-13-9, 17086-28-1, 564-25-0; promethazine, 58-33-3, 60-87-7; trifluoperazine, 117-89-5, 440-17-5; aminoacridine, 134-50-9, 27254-80-4, 90-45-9; propane, 74-98-6; 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone; Aminacrine, 90-45-9; Anti-Bacterial Agents; Antineoplastic Agents; Benzoxazoles; Promethazine, 60-87-7; Propane, 74-98-6; Proton Pumps; Trifluoperazine, 117-89-5 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Baráth, Zoltán Lajos AU - Radics, R AU - Spengler, Gabriella AU - Ocsovszki, Imre AU - Kawase, M AU - Motohashi, N AU - Shirataki, Y AU - Shah, A AU - Molnár, József TI - Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells JF - IN VIVO J2 - IN VIVO VL - 20 PY - 2006 IS - 5 SP - 645 EP - 649 PG - 5 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/1822649 ID - 1822649 N1 - Chemicals/CAS: chromone, 491-38-3; coumarin 3 carboxylic acid, 531-81-7; Chromones; formylchromone Manufacturers: Aldrich, United States Megjegyzés-22286496 Chemicals/CAS: chromone, 491-38-3; coumarin 3 carboxylic acid, 531-81-7; Chromones; formylchromone Manufacturers: Aldrich, United States Institute of Medical Microbiology and Immunobiology, Faculty of General Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary Institute of Biochemistry, Albert Szent-Györgyi Medical University, Szeged, Hungary Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan Department of Medicinal Chemistry, Meiji Pharmaceutical University, Tokyo, Japan Department of Chemistry, Saurashtra University, Rajkot, India Cited By :23 Export Date: 8 February 2020 CODEN: IVIVE Correspondence Address: Molnár, J.; Institute of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary; email: molnarj@comser.szote.u-szeged.hu Chemicals/CAS: chromone, 491-38-3; coumarin 3 carboxylic acid, 531-81-7; Chromones; formylchromone Manufacturers: Aldrich, United States Institute of Medical Microbiology and Immunobiology, Faculty of General Medicine, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary Institute of Biochemistry, Albert Szent-Györgyi Medical University, Szeged, Hungary Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan Department of Medicinal Chemistry, Meiji Pharmaceutical University, Tokyo, Japan Department of Chemistry, Saurashtra University, Rajkot, India Cited By :23 Export Date: 19 January 2021 CODEN: IVIVE Correspondence Address: Molnár, J.; Institute of Medical Microbiology and Immunobiology, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary; email: molnarj@comser.szote.u-szeged.hu Chemicals/CAS: chromone, 491-38-3; coumarin 3 carboxylic acid, 531-81-7; Chromones; formylchromone Manufacturers: Aldrich, United States LA - English DB - MTMT ER - TY - JOUR AU - Luo, LF AU - Molnár, József AU - Ding, H AU - Lv, XG AU - Spengler, Gabriella TI - Ultrasound absorption and entropy production in biological tissue: a novel approach to anticancer therapy JF - DIAGNOSTIC PATHOLOGY J2 - DIAGN PATHOL VL - 1 PY - 2006 PG - 6 SN - 1746-1596 DO - 10.1186/1746-1596-1-35 UR - https://m2.mtmt.hu/api/publication/1822648 ID - 1822648 N1 - Megjegyzés-22263894 Z9: 9 LA - English DB - MTMT ER - TY - JOUR AU - Luo, LF AU - Molnár, József AU - Ding, H AU - Lv, XG AU - Spengler, Gabriella TI - Physicochemical attack against solid tumors based on the reversal of direction of entropy flow: an attempt to introduce thermodynamics in anticancer therapy JF - DIAGNOSTIC PATHOLOGY J2 - DIAGN PATHOL VL - 1 PY - 2006 SN - 1746-1596 DO - 10.1186/1746-1596-1-43 UR - https://m2.mtmt.hu/api/publication/1822647 ID - 1822647 N1 - Megjegyzés-22263895 Z9: 5 LA - English DB - MTMT ER - TY - CONF AU - Molnár, J AU - Demirel-Kars, M AU - Engi, H AU - Spengler, Gabriella AU - Gyémánt, N AU - Molnár, Péter AU - Schuhmacher, U AU - Makoviczky, J TI - Reversal of Resistance of Cancer Cells by Inhibition of Efflux Pump T2 - János Fischer Memorial Symposium, Biological Research Center of the Hungarian Academy of Sciences PY - 2006 SP - 13 UR - https://m2.mtmt.hu/api/publication/2121384 ID - 2121384 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Molnár, Annamária AU - Schelz, Zsuzsanna AU - Amaral, L AU - Sharples, D AU - Molnár, József TI - The mechanism of plasmid curing in bacteria JF - CURRENT DRUG TARGETS J2 - CURR DRUG TARGETS VL - 7 PY - 2006 IS - 7 SP - 823 EP - 841 PG - 19 SN - 1389-4501 DO - 10.2174/138945006777709601 UR - https://m2.mtmt.hu/api/publication/1822650 ID - 1822650 N1 - Megjegyzés-21808187 : FN Thomson Reuters Web of Knowledge Z9: 12 WC: Pharmacology & Pharmacy Megjegyzés-21006151 PubMed ID: 16842214 Chemicals/CAS: 7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents Megjegyzés-21140023 PubMed ID: 16842214 Chemicals/CAS: 7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents Megjegyzés-22286552 Chemicals/CAS: 7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents Megjegyzés-22286572 Chemicals/CAS: 7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents Megjegyzés-22287098 Chemicals/CAS: 7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents Megjegyzés-22307114 Chemicals/CAS: 7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents Megjegyzés-22316634 Chemicals/CAS: 7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents Megjegyzés-23086383 N1 : Chemicals/CAS7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents Megjegyzés-23086618 N1 : Chemicals/CAS7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents Megjegyzés-22406635 N1 Source: Scopus N1 doi: 10.2174/138945006777709601 N1 PubMed ID: 16842214 N1 Language of Original Document: English N1 Chemicals/CAS: 7 hydroxychlorpromazine, 2095-62-7; amitriptyline, 50-48-6, 549-18-8; chlorphenethazine, 2095-24-1, 22632-00-4; chlorpromazine n oxide, 1672-76-0; chlorpromazine n,s dioxide, 10404-90-7; chlorpromazine sulfoxide, 969-99-3; chlorpromazine, 50-53-3, 69-09-0; desipramine, 50-47-5, 58-28-6; diethazine, 341-70-8, 60-91-3; imipramine, 113-52-0, 50-49-7; lactose, 10039-26-6, 16984-38-6, 63-42-3, 64044-51-5; levomepromazine, 1236-99-3, 60-99-1, 7104-38-3; maprotiline, 10262-69-8, 10347-81-6; norchlorpromazine, 1225-64-5; promazine, 53-60-1, 58-40-2; promethazine, 58-33-3, 60-87-7; protriptyline, 1225-55-4, 438-60-8; thiethylperazine, 1420-55-9; thioridazine, 130-61-0, 50-52-2; Heterocyclic Compounds; Intercalating Agents N1 References: Carlos, F., Cuevas, A., Chicure, M.E., (1992) Cell, 70, pp. 189-199; Amaral, L., Viveiros, M., Molnar, J., (2004) In Vivo, 18 (6), pp. 725-731; Ordway, D., Viveiros, M., Leandro, C., Amaral, L., (2003) Antimicrob. 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Agents Chemother., 41, pp. 2067-2075 LA - English DB - MTMT ER - TY - THES AU - Spengler, Gabriella TI - Attempts to reduce drug resistance of bacteria and cancer cells PB - Szegedi Tudományegyetem (SZTE) PY - 2006 SP - 53 UR - https://m2.mtmt.hu/api/publication/2241107 ID - 2241107 LA - English DB - MTMT ER - TY - JOUR AU - Wolfart, K AU - Spengler, Gabriella AU - Kawase, M AU - Motohashi, N AU - Molnár, József AU - Viveiros, M AU - Amaral, L TI - Synergistic interaction between proton pump inhibitors and resistance modifiers: Promoting effects of antibiotics and plasmid curing JF - IN VIVO J2 - IN VIVO VL - 20 PY - 2006 IS - 3 SP - 367 EP - 372 PG - 6 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/1822651 ID - 1822651 N1 - Megjegyzés-22257284 Chemicals/CAS: aminoacridine, 134-50-9, 27254-80-4, 90-45-9; ampicillin, 69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0; erythromycin, 114-07-8, 70536-18-4; imipramine, 113-52-0, 50-49-7; promethazine, 58-33-3, 60-87-7; tetracycline, 23843-90-5, 60-54-8, 64-75-5; verapamil, 152-11-4, 52-53-9; Aminacrine, 90-45-9; Ampicillin, 69-53-4; Anti-Bacterial Agents; Erythromycin, 114-07-8; Promethazine, 60-87-7; Proton Pumps; Tetracycline, 60-54-8; Verapamil, 52-53-9 Tradenames: melipramin, Egis; penbritin, Beecham, Hungary; pipolphen, Egis; verapamil, Chinoin, Hungary Manufacturers: Beecham, Hungary; Chimimport, Hungary; Chinoin, Hungary; Egis Megjegyzés-22287100 Chemicals/CAS: aminoacridine, 134-50-9, 27254-80-4, 90-45-9; ampicillin, 69-52-3, 69-53-4, 7177-48-2, 74083-13-9, 94586-58-0; erythromycin, 114-07-8, 70536-18-4; imipramine, 113-52-0, 50-49-7; promethazine, 58-33-3, 60-87-7; tetracycline, 23843-90-5, 60-54-8, 64-75-5; verapamil, 152-11-4, 52-53-9; Aminacrine, 90-45-9; Ampicillin, 69-53-4; Anti-Bacterial Agents; Erythromycin, 114-07-8; Promethazine, 60-87-7; Proton Pumps; Tetracycline, 60-54-8; Verapamil, 52-53-9 Tradenames: melipramin, Egis; penbritin, Beecham, Hungary; pipolphen, Egis; verapamil, Chinoin, Hungary Manufacturers: Beecham, Hungary; Chimimport, Hungary; Chinoin, Hungary; Egis LA - English DB - MTMT ER - TY - JOUR AU - Kawase, M AU - Sakagami, H AU - Motohashi, N AU - Hauer, H AU - Chatterjee, SS AU - Spengler, Gabriella AU - Vigyikanne, AV AU - Molnár, Annamária AU - Molnár, József TI - Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity JF - IN VIVO J2 - IN VIVO VL - 19 PY - 2005 IS - 4 SP - 705 EP - 711 PG - 7 SN - 0258-851X UR - https://m2.mtmt.hu/api/publication/1822653 ID - 1822653 LA - English DB - MTMT ER - TY - JOUR AU - Sharples, D AU - Spengler, Gabriella AU - Molnár, József AU - Antal, Z AU - Molnár, A AU - Kiss T., János AU - Szabó, JA AU - Hilgeroth, A AU - Gallo, S AU - Mahamoud, A AU - Barbe, J TI - Erratum: The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA (European Journal of Medicinal Chemistry (2005) 40 (195-202) DOI: 10.1016/j.ejmech.2004.10.011) JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 40 PY - 2005 IS - 10 SP - 1070 SN - 0223-5234 DO - 10.1016/j.ejmech.2005.04.001 UR - https://m2.mtmt.hu/api/publication/2738424 ID - 2738424 LA - English DB - MTMT ER - TY - JOUR AU - Sharples, D AU - Spengler, Gabriella AU - Molnár, József AU - Antal, Zsuzsanna AU - Molnár, Annamária AU - Kiss T., János AU - Szabó, JA AU - Hilgeroth, A AU - Gallo, S AU - Mahamoud, A AU - Barbe, JB TI - The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA. JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 40 PY - 2005 IS - 2 SP - 195 EP - 202 PG - 8 SN - 0223-5234 DO - 10.1016/j.ejmech.2004.10.011 UR - https://m2.mtmt.hu/api/publication/247310 ID - 247310 N1 - Corrigendum: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 40 (10), 1070 (2005) LA - English DB - MTMT ER - TY - JOUR AU - Gyemant, N AU - Molnár, Annamária AU - Spengler, Gabriella AU - Mándi, Yvette AU - Szabo, M AU - Molnár, József TI - Bacterial models for tumor development JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 51 PY - 2004 IS - 3 SP - 321 EP - 332 PG - 12 SN - 1217-8950 DO - 10.1556/AMicr.51.2004.3.10 UR - https://m2.mtmt.hu/api/publication/1915151 ID - 1915151 LA - English DB - MTMT ER - TY - JOUR AU - Madureira, AM AU - Spengler, Gabriella AU - Molnár, Annamária AU - Varga, A AU - Molnár, József AU - Abreu, PM AU - Ferreira, MJU TI - Effect of cycloartanes on reversal of multidrug resistance and apoptosis induction on mouse lymphoma cells JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 24 PY - 2004 IS - 2B SP - 859 EP - 864 PG - 6 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822656 ID - 1822656 N1 - Megjegyzés-22316668 Chemicals/CAS: fluorescein isothiocyanate, 25168-13-2, 27072-45-3, 3326-32-7; lipocortin 5, 111237-10-6; propidium iodide, 25535-16-4; rhodamine 123, 62669-70-9; trihexyphenidyl, 144-11-6, 52-49-3; cycloartane, 511-64-8; Plant Extracts; Triterpenes Megjegyzés-22406583 N1 Source: Scopus N1 PubMed ID: 15161038 N1 Language of Original Document: English N1 Chemicals/CAS: fluorescein isothiocyanate, 25168-13-2, 27072-45-3, 3326-32-7; lipocortin 5, 111237-10-6; propidium iodide, 25535-16-4; rhodamine 123, 62669-70-9; trihexyphenidyl, 144-11-6, 52-49-3; cycloartane, 511-64-8; Plant Extracts; Triterpenes N1 References: Kim, S.E., Hong, Y.S., Kim, Y.C., Lee, J.J., Mode of action of torilin in multidrug-resistance cancer cell lines (1998) Planta Med, 64, pp. 335-338; Wiese, M., Pajeva, I.K., Structure-activity relationships of multidrug resistance reversers (2001) Curr Med Chem, 8, pp. 685-713; Wesolowska, O., Molnár, J., Motohashi, N., Michalak, K., Inhibition of P-glycoprotein transport function by N-acylphenothiazines (2002) Anticancer Res, 22, pp. 2863-2868; Tolomeo, M., Simoni, D., Drug resistance and apoptosis in cancer treatment: Development of new apoptosis-inducing agents active in drug resistant malignancies (2002) Curr Med Chem, 2, pp. 387-401; Hartwell, J.L., Plants used against cancer. 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lipocortin 5, 111237-10-6; propidium iodide, 25535-16-4; rhodamine 123, 62669-70-9; trihexyphenidyl, 144-11-6, 52-49-3; cycloartane, 511-64-8; Plant Extracts; Triterpenes LA - English DB - MTMT ER - TY - JOUR AU - Molnár, József AU - Molnár, Annamária AU - Spengler, Gabriella AU - Mándi, Yvette TI - Infectious plasmid resistance and efflux pump mediated resistance JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 51 PY - 2004 IS - 3 SP - 333 EP - 349 PG - 17 SN - 1217-8950 DO - 10.1556/AMicr.51.2004.3.11 UR - https://m2.mtmt.hu/api/publication/1915152 ID - 1915152 N1 - Megjegyzés-21005768 PubMed ID: 15571073 Chemicals/CAS: alimemazine, 84-96-8; chlorprothixene, 113-59-7, 6469-93-8; desipramine, 50-47-5, 58-28-6; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; noxiptiline, 3362-45-6, 4985-15-3; procaine, 51-05-8, 59-46-1; profenamine, 1094-08-2, 522-00-9; promazine, 53-60-1, 58-40-2; protriptyline, 1225-55-4, 438-60-8; thiazinamium, 2338-21-8; tolonium chloride, 92-31-9; trimipramine, 25332-13-2, 739-71-9; Anti-Bacterial Agents; Proton Pumps Megjegyzés-21005772 PubMed ID: 15571073 Chemicals/CAS: alimemazine, 84-96-8; chlorprothixene, 113-59-7, 6469-93-8; desipramine, 50-47-5, 58-28-6; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; noxiptiline, 3362-45-6, 4985-15-3; procaine, 51-05-8, 59-46-1; profenamine, 1094-08-2, 522-00-9; promazine, 53-60-1, 58-40-2; protriptyline, 1225-55-4, 438-60-8; thiazinamium, 2338-21-8; tolonium chloride, 92-31-9; trimipramine, 25332-13-2, 739-71-9; Anti-Bacterial Agents; Proton Pumps Megjegyzés-21005791 PubMed ID: 15571073 Chemicals/CAS: alimemazine, 84-96-8; chlorprothixene, 113-59-7, 6469-93-8; desipramine, 50-47-5, 58-28-6; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; noxiptiline, 3362-45-6, 4985-15-3; procaine, 51-05-8, 59-46-1; profenamine, 1094-08-2, 522-00-9; promazine, 53-60-1, 58-40-2; protriptyline, 1225-55-4, 438-60-8; thiazinamium, 2338-21-8; tolonium chloride, 92-31-9; trimipramine, 25332-13-2, 739-71-9; Anti-Bacterial Agents; Proton Pumps Megjegyzés-23086386 N1 : Chemicals/CASalimemazine, 84-96-8; chlorprothixene, 113-59-7, 6469-93-8; desipramine, 50-47-5, 58-28-6; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; noxiptiline, 3362-45-6, 4985-15-3; procaine, 51-05-8, 59-46-1; profenamine, 1094-08-2, 522-00-9; promazine, 53-60-1, 58-40-2; protriptyline, 1225-55-4, 438-60-8; thiazinamium, 2338-21-8; tolonium chloride, 92-31-9; trimipramine, 25332-13-2, 739-71-9; Anti-Bacterial Agents; Proton Pumps Megjegyzés-23086619 N1 : Chemicals/CASalimemazine, 84-96-8; chlorprothixene, 113-59-7, 6469-93-8; desipramine, 50-47-5, 58-28-6; lidocaine, 137-58-6, 24847-67-4, 56934-02-2, 73-78-9; noxiptiline, 3362-45-6, 4985-15-3; procaine, 51-05-8, 59-46-1; profenamine, 1094-08-2, 522-00-9; promazine, 53-60-1, 58-40-2; protriptyline, 1225-55-4, 438-60-8; thiazinamium, 2338-21-8; tolonium chloride, 92-31-9; trimipramine, 25332-13-2, 739-71-9; Anti-Bacterial Agents; Proton Pumps LA - English DB - MTMT ER - TY - JOUR AU - Motohashi, N AU - Wakabayashi, H AU - Kurihara, T AU - Fukushima, H AU - Yamada, T AU - Kawase, M AU - Sohara, Y AU - Tani, S AU - Shirataki, Y AU - Sakagami, H AU - Satoh, K AU - Nakashima, H AU - Molnár, Annamária AU - Spengler, Gabriella AU - Gyemant, N AU - Ugocsai, Katalin AU - Molnár, József TI - Biological activity of Barbados cherry (Acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions JF - PHYTOTHERAPY RESEARCH J2 - PHYTOTHER RES VL - 18 PY - 2004 IS - 3 SP - 212 EP - 223 PG - 12 SN - 0951-418X DO - 10.1002/ptr.1426 UR - https://m2.mtmt.hu/api/publication/1822657 ID - 1822657 N1 - Megjegyzés-22316566 Z9: 19 LA - English DB - MTMT ER - TY - JOUR AU - Motohashi, N AU - Wakabayashi, H AU - Kurihara, T AU - Fukushima, H AU - Yamada, T AU - Kawase, M AU - Sohara, Y AU - Tani, S AU - Shirataki, Y AU - Sakagam, H AU - Satoh, K AU - Nakashima, H AU - Molnar, A AU - Spengler, Gabriella AU - Gyemant, N AU - Ugocsai, Katalin AU - Molnár, József TI - BIOLOGICAL ACTIVITY OF BARBADOS CHERRY (ACEROLA FRUITS, FRUIT OF MALPIGHIA EMARGINATA DC.) EXTRACTS AND FRACTIONS JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 24 PY - 2004 IS - 5D SP - 3569 EP - 3570 PG - 2 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822655 ID - 1822655 N1 - WoS:hiba:000205415300332 2019-03-04 01:20 cikkazonosító nem egyezik LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Molnár, Annamária AU - Klausz, Gergely AU - Mándi, Yvette AU - Kawase, N AU - Motohashi, N AU - Molnár, József TI - The antimotility action of trifluoromethyl ketone on some Gram-negative bacteria JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 51 PY - 2004 IS - 3 SP - 351 EP - 358 PG - 8 SN - 1217-8950 DO - 10.1556/AMicr.51.2004.3.12 UR - https://m2.mtmt.hu/api/publication/1359982 ID - 1359982 N1 - Megjegyzés-23086676 N1 : Chemicals/CASclarithromycin, 81103-11-9; proton, 12408-02-5, 12586-59-3; Anti-Infective Agents; Ketones; Proton Pumps LA - English DB - MTMT ER - TY - CONF AU - Spengler, Gabriella AU - Molnar, A AU - Klausz, Gergely AU - Mándi, Yvette AU - Kawase, M AU - Amaral, L AU - Molnár, József TI - Plasmid elimination and antimotility studies in the presence of a trifluoroketone proton pump inhibitor on Escherichia coli and Helicobacter pylori strains T2 - 6th European Congress of Chemotherapy and Infection, 24th Interdisciplinary Meeting Chemotherapy Anti-infections PY - 2004 SP - S199 EP - S199 UR - https://m2.mtmt.hu/api/publication/1158127 ID - 1158127 LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Molnár, Annamária AU - Klausz, Gergely AU - Mándi, Yvette AU - Kawase, M AU - Motohashi, N AU - Molnár, József TI - Inhibitory action of a new proton pump inhibitor, trifluoromethyl ketone derivative, against the motility of clarithromycin-susceptible and-resistant Helicobacter pylori JF - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS J2 - INT J ANTIMICROB AG VL - 23 PY - 2004 IS - 6 SP - 631 EP - 633 PG - 3 SN - 0924-8579 DO - 10.1016/j.ijantimicag.2003.11.010 UR - https://m2.mtmt.hu/api/publication/1158125 ID - 1158125 AB - In the process of endourological development a variety of foreign bodies have been invented besides urinary catheters, on which biofilm can be formed. Bacteria in the biofilm are less susceptible to antibiotics. An additional problem of medical biomaterials in the urinary tract environment is the development of encrustation and consecutive obstruction. The most promising prevention strategy for bacterial biofilms is the production of materials with anti-adhesive surfaces such as heparin. Although heparin-coated ureteral stents are expensive, they justify their cost. Our studies show that such devices are protected against incrustation and biofilm formation for a longer period of time: 6-12 months, both in vitro and in vivo. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Alibert, S AU - Santelli-Rouvier, C AU - Castaing, M AU - Berthlot, M AU - Spengler, Gabriella AU - Molnár, József AU - Barbe, J TI - Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells JF - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY J2 - EUR J MED CHEM VL - 38 PY - 2003 IS - 3 SP - 253 EP - 263 PG - 11 SN - 0223-5234 DO - 10.1016/S0223-5234(03)00018-7 UR - https://m2.mtmt.hu/api/publication/1822659 ID - 1822659 N1 - Megjegyzés-24278164 N1 CAPLUS AN 2003:236102(Journal) LA - English DB - MTMT ER - TY - JOUR AU - Kawase, M AU - Motohashi, N AU - Satoh, K AU - Sakagami, H AU - Nakashima, H AU - Tani, S AU - Shirataki, Y AU - Kurihara, T AU - Spengler, Gabriella AU - Wolfard, K AU - Molnár, József TI - Biological activity of persimmon (Diospyros kaki) peel extracts JF - PHYTOTHERAPY RESEARCH J2 - PHYTOTHER RES VL - 17 PY - 2003 IS - 5 SP - 495 EP - 500 PG - 6 SN - 0951-418X DO - 10.1002/ptr.1183 UR - https://m2.mtmt.hu/api/publication/1822658 ID - 1822658 N1 - Megjegyzés-23216331 N1 : Chemicals/CASacetone, 67-64-1; hexane, 110-54-3; oxygen, 7782-44-7; verapamil, 152-11-4, 52-53-9; xanthine oxidase, 9002-17-9; Antineoplastic Agents, Phytogenic; Plant Extracts LA - English DB - MTMT ER - TY - JOUR AU - Spengler, Gabriella AU - Miczák, András AU - Hajdú, Edit AU - Kawase, M AU - Amaral, L AU - Molnár, József TI - Enhancement of plasmid curing by 9-aminoacridine and two phenothiazines in the presence of proton pump inhibitor 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone JF - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS J2 - INT J ANTIMICROB AG VL - 22 PY - 2003 IS - 3 SP - 223 EP - 227 PG - 5 SN - 0924-8579 DO - 10.1016/S0924-8579(03)00207-3 UR - https://m2.mtmt.hu/api/publication/1351209 ID - 1351209 N1 - Tradenames: pipolphen, Egis, Hungary Manufacturers: Chinoin, Hungary; Egis, Hungary; Sigma, United States; Aldrich Megjegyzés-23086575 N1 : Chemicals/CASaminoacridine, 134-50-9, 27254-80-4, 90-45-9; doxycycline, 10592-13-9, 17086-28-1, 564-25-0; promethazine, 58-33-3, 60-87-7; trifluoperazine, 117-89-5, 440-17-5; Acetone, 67-64-1; Aminacrine, 90-45-9; Promethazine, 60-87-7; Proton Pumps; Trifluoperazine, 117-89-5 Megjegyzés-23086630 N1 : Chemicals/CASaminoacridine, 134-50-9, 27254-80-4, 90-45-9; doxycycline, 10592-13-9, 17086-28-1, 564-25-0; promethazine, 58-33-3, 60-87-7; trifluoperazine, 117-89-5, 440-17-5; Acetone, 67-64-1; Aminacrine, 90-45-9; Promethazine, 60-87-7; Proton Pumps; Trifluoperazine, 117-89-5 AB - Plasmid-containing bacteria often cause serious therapeutic failure during the treatment of infectious diseases. The selection of resistant-mutant strains and the transfer of mobile genetic determinants (such as plasmids and transposons) of resistance promote increased antibiotic resistance. In the last 30 years the antiplasmid effect of acridine dyes, ethidium bromide, sodium dodecyl sulphate and phenothiazines was described. The main aim of this study was to test the mechanism of the antiplasmid effect of promethazine and 9-aminoacridine on doxycycline-resistant enteric bacteria. The antiplasmid effects of promethazine and 9-aminoacridine were studied on plasmid elimination of native plasmid DNA and plasmid DNA isolated from drug-treated cells of plasmid-containing Escherichia coli, Citrobacter freundii and Enterobacter cloacae. The effects of some phenothiazines on plasmid profiles of bacterial strains isolated from urinary tract infections were analysed by agarose gel electrophoresis. Various complex of plasmid DNA were identified in the presence of promethazine, trifluoperazine and 9-aminoacridine in the agarose gel electrophoresis. Doxycycline resistance of tested enteric bacteria was the target of 'curing' in the presence of promethazine and trifluoperazine. The frequency of elimination of tetracycline resistance was low despite the formation of antiplasmid compounds complex with isolated plasmid DNA. Tetracycline resistance plasmid was isolated and re-transformed. The plasmid curing effects of promethazine, trifluoperazine and 9-aminoacridine were increased in the presence of a trifluoroketone proton pump inhibitor on E. coli K12 LE140 strain in a model experiment. We propose that the inefficient penetration of antiplasmid compounds could be responsible for the weak plasmid-curing effect in some clinical isolates and that membrane active, calmodulin- and proton pump inhibitors may be combined for plasmid curing in antibiotic-resistant bacteria. © 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. LA - English DB - MTMT ER - TY - JOUR AU - Misbahi, H AU - Brouant, P AU - Hever, Anikó AU - Molnár, Annamária AU - Wolfard, Krisztina AU - Spengler, Gabriella AU - Mefetah, H AU - Molnár, József AU - Barbe, J TI - Benzo[b]-1,8-naphthyridine derivatives: Synthesis and reversal activity on multidrug resistance JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 22 PY - 2002 IS - 4 SP - 2097 EP - 2101 PG - 5 SN - 0250-7005 UR - https://m2.mtmt.hu/api/publication/1822660 ID - 1822660 LA - English DB - MTMT ER -