@article{MTMT:34556458, title = {Comparative Solution Equilibrium Studies on Anticancer Estradiol-Based Conjugates and Their Copper Complexes}, url = {https://m2.mtmt.hu/api/publication/34556458}, author = {Enyedy, Éva Anna and Giricz, Anett and Petrasheuskaya, Tatsiana and Mészáros, János Péter and May, Nóra Veronika and Spengler, Gabriella and Kovács, Ferenc and Molnár, Barnabás and Nagyné Frank, Éva}, doi = {10.3390/inorganics12020049}, journal-iso = {INORGANICS}, journal = {INORGANICS}, volume = {12}, unique-id = {34556458}, abstract = {Steroids are often considered valuable molecular tools for the development of anticancer agents with improved pharmacological properties. Conjugation of metal chelating moieties with a lipophilic sterane backbone is a viable option to obtain novel anticancer compounds. In this work, two estradiol-based hybrid molecules (PMA-E2 and DMA-E2) with an (N,N,O) binding motif and their Cu(II) complexes were developed. The lipophilicity, solubility, and acid-base properties of the novel ligands were determined by the combined use of UV-visible spectrophotometry, pH-potentiometry, and 1H NMR spectroscopy. The solution speciation and redox activity of the Cu(II) complexes were also investigated by means of UV-visible and electron paramagnetic resonance spectroscopy. Two structurally analogous ligands (PMAP and DMAP) were also included in the studies for better interpretation of the solution chemical data obtained. Three pKa values were determined for all ligands, revealing the order of the deprotonation steps: pyridinium-NH+ or NH(CH3)2+, secondary NH2+, and OH. The dimethylamine derivatives (DMA-E2, DMAP) are found in their H2L+ forms in solution at pH 7.4, whereas the fraction of the neutral HL species is significant (34–37%) in the case of the pyridine nitrogen-containing derivatives (PMA-E2, PMAP). Both estradiol derivatives were moderately cytotoxic in human breast (MCF-7) and colon adenocarcinoma (Colo-205) cells (IC50 = 30–63 μM). They form highly stable complexes with Cu(II) ions capable of oxidizing ascorbate and glutathione. These Cu(II) complexes are somewhat more cytotoxic (IC50 = 15–45 μM) than their corresponding ligands and show a better selectivity profile.}, year = {2024}, eissn = {2304-6740}, orcid-numbers = {Enyedy, Éva Anna/0000-0002-8058-8128; Mészáros, János Péter/0000-0001-6301-5259; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Nagyné Frank, Éva/0000-0002-1332-0551} } @article{MTMT:34715381, title = {Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/34715381}, author = {Hegedűs, Dóra and Szemerédi, Nikoletta and Gábor, Maja and Sas, Judit and Belasri, Khadija and Szatmári, István and Spengler, Gabriella}, doi = {10.21873/anticanres.16910}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {44}, unique-id = {34715381}, issn = {0250-7005}, year = {2024}, eissn = {1791-7530}, pages = {1149-1160}, orcid-numbers = {Szatmári, István/0000-0002-8571-5229; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:34501021, title = {Chemical composition, antimicrobial and antiproliferative activity of the essential oil from Ambrosia artemisiifolia L}, url = {https://m2.mtmt.hu/api/publication/34501021}, author = {Kovács, Balázs and Szemerédi, Nikoletta and Csikós, Orsolya and Kiss, Tivadar and Veres, Katalin and Spengler, Gabriella and Csupor-Löffler, Boglárka and Csupor, Dezső}, doi = {10.1080/10412905.2024.2303449}, journal-iso = {J ESSENT OIL RES}, journal = {JOURNAL OF ESSENTIAL OIL RESEARCH}, volume = {36}, unique-id = {34501021}, issn = {1041-2905}, year = {2024}, eissn = {2163-8152}, pages = {30-42}, orcid-numbers = {Kiss, Tivadar/0000-0003-3538-377X; Veres, Katalin/0000-0001-7108-3622; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:34601216, title = {Organometallic Ru(II), Rh(III) and Re(I) complexes of sterane-based bidentate ligands: Synthesis, solution speciation, interaction with biomolecules and anticancer activity}, url = {https://m2.mtmt.hu/api/publication/34601216}, author = {Pivarcsik, Tamás and Kiss, Márton Attila and Rapuš, Uroš and Kljun, Jakob and Spengler, Gabriella and Nagyné Frank, Éva and Turel, Iztok and Enyedy, Éva Anna}, doi = {10.1039/D3DT04138G}, journal-iso = {DALTON T}, journal = {DALTON TRANSACTIONS}, volume = {53}, unique-id = {34601216}, issn = {1477-9226}, abstract = {In this study, we present the synthesis, characterization and in vitro cytotoxicity of six organometallic [Ru(II)(η6-p-cymene)(N,N)Cl]Cl, [Rh(III)(η5-C5Me5)(N,N)Cl]Cl and [Re(I)(CO)3(N,N)Cl] complexes, in which the (N,N) ligands are sterane-based 2,2’-bipyridine derivatives (4-Me-bpy-St-OH,...}, year = {2024}, eissn = {1477-9234}, pages = {4984-5000}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Nagyné Frank, Éva/0000-0002-1332-0551; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:34536068, title = {A Comparative Study on the Complexation of the Anticancer Iron Chelator VLX600 with Essential Metal Ions}, url = {https://m2.mtmt.hu/api/publication/34536068}, author = {Pósa, Vivien and Federa, Anja and Cseh, Klaudia and Wenisch, Dominik and Spengler, Gabriella and May, Nóra Veronika and Lihi, Norbert and Samu, Gergely Ferenc and Jakupec, Michael A. and Keppler, Bernhard K. and Kowol, Christian R. and Enyedy, Éva Anna}, doi = {10.1021/acs.inorgchem.3c03259}, journal-iso = {INORG CHEM}, journal = {INORGANIC CHEMISTRY}, volume = {63}, unique-id = {34536068}, issn = {0020-1669}, year = {2024}, eissn = {1520-510X}, pages = {2401-2417}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; May, Nóra Veronika/0000-0003-4770-4681; Lihi, Norbert/0000-0003-2986-2395; Samu, Gergely Ferenc/0000-0002-3239-9154; Jakupec, Michael A./0000-0001-7945-1426; Kowol, Christian R./0000-0002-8311-1632; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:34746290, title = {Antibacterial Potential of Symmetrical Twin-Drug 3,6-Diaminoxanthones}, url = {https://m2.mtmt.hu/api/publication/34746290}, author = {Resende, D.I.S.P. and Durães, F. and Zubarioglu, S. and Freitas-Silva, J. and Szemerédi, Nikoletta and Pinto, M. and Pinto, E. and Martins, da Costa P. and Spengler, Gabriella and Sousa, E.}, doi = {10.3390/ph17020209}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {17}, unique-id = {34746290}, abstract = {Global health faces a significant issue with the rise of infectious diseases caused by bacteria, fungi, viruses, and parasites. The increasing number of multi-drug resistant microbial pathogens severely threatens public health worldwide. Antibiotic-resistant pathogenic bacteria, in particular, present a significant challenge. Therefore, there is an urgent need to identify new potential antimicrobial targets and discover new chemical entities that can potentially reverse bacterial resistance. The main goal of this research work was to create and develop a library of 3,6-disubstituted xanthones based on twin drugs and molecular extension approaches to inhibit the activity of efflux pumps. The process involved synthesizing 3,6-diaminoxanthones through the reaction of 9-oxo-9H-xanthene-3,6-diyl bis(trifluoromethanesulfonate) with various primary and secondary amines. The resulting 3,6-disubstituted xanthone derivatives were then tested for their in vitro antimicrobial properties against a range of pathogenic strains and their efficacy in inhibiting the activity of efflux pumps, biofilm formation, and quorum-sensing. Several compounds have exhibited effective antibacterial properties against the Gram-positive bacterial species tested. Xanthone 16, in particular, has demonstrated exceptional efficacy with a remarkable MIC of 11 µM (4 µg/mL) against reference strains Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, and 25 µM (9 µg/mL) against methicillin-resistant S. aureus 272123. Furthermore, some derivatives have shown potential as antibiofilm agents in a crystal violet assay. The ethidium bromide accumulation assay pinpointed certain compounds inhibiting bacterial efflux pumps. The cytotoxic effect of the most promising compounds was examined in mouse fibroblast cell line NIH/3T3, and two monoamine substituted xanthone derivatives with a hydroxyl substituent did not exhibit any cytotoxicity. Overall, the nature of the substituent was critical in determining the antimicrobial spectra of aminated xanthones. © 2024 by the authors.}, keywords = {ARTICLE; MOUSE; CYTOTOXICITY; human; high performance liquid chromatography; controlled study; nonhuman; enzyme linked immunosorbent assay; quality control; Fluorometry; human cell; unclassified drug; minimum inhibitory concentration; crystal structure; particle size; chemical structure; CYCLIZATION; multidrug resistance; multidrug resistance; protein purification; Staphylococcus aureus; Serratia marcescens; Antifungal activity; antibacterial activity; antibacterial activity; Biofilm; Pseudomonas aeruginosa; Enterococcus faecalis; bacterial virulence; drug synthesis; Column chromatography; XANTHONES; efflux pump; chemical compound; Molecular docking; heteronuclear single quantum coherence; quadrupole mass spectrometry; quorum sensing; quorum sensing; xanthone derivative; cytotoxicity assay; Biofilm inhibition; 3,6 diaminoxanthone}, year = {2024}, eissn = {1424-8247}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:34753868, title = {Nitrogen-containing andrographolide derivatives with multidrug resistance reversal effects in cancer cells}, url = {https://m2.mtmt.hu/api/publication/34753868}, author = {Ribeiro, Joana R. L. and Szemerédi, Nikoletta and Gonçalves, Bruno M. F. and Spengler, Gabriella and Afonso, Carlos A. M. and Ferreira, Maria-José U.}, doi = {10.1039/D3MD00711A}, journal-iso = {RSC MED CHEM}, journal = {RSC MEDICINAL CHEMISTRY}, volume = {15}, unique-id = {34753868}, abstract = {A set of twenty-three new andrographolide derivatives, bearing a nitrogen-containing moiety, is reported. Several derivatives were found to be promising leads for reversing cancer multidrug resistance.}, year = {2024}, eissn = {2632-8682}, pages = {1348-1361}, orcid-numbers = {Gonçalves, Bruno M. F./0000-0002-3137-5329; Spengler, Gabriella/0000-0001-8085-0950; Afonso, Carlos A. M./0000-0002-7284-5948; Ferreira, Maria-José U./0000-0002-8742-1486} } @article{MTMT:34729015, title = {Új minimálinvazív kezelési lehetőségek jó- és rosszindulatú fül-orr-gégészeti betegségekben nanoszerkezetű hatóanyag-leadó rendszerek alkalmazásával = New minimally invasive treatment options in benign and malignant otorhinolaryngological diseases using nanostructured drug delivery systems}, url = {https://m2.mtmt.hu/api/publication/34729015}, author = {Szabó, Diána and Janovák, László and Abdelghafour, Mohamed M. and Takács, Tamás and Csanády, Miklós ifj. and Spengler, Gabriella and Szakács, László and Csanády, Miklós and Rovó, László}, doi = {10.1556/650.2024.32978}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34729015}, issn = {0030-6002}, year = {2024}, eissn = {1788-6120}, pages = {370-378}, orcid-numbers = {Janovák, László/0000-0002-2066-319X; Abdelghafour, Mohamed M./0000-0002-7895-4555; Spengler, Gabriella/0000-0001-8085-0950; Rovó, László/0000-0003-1782-1756} } @article{MTMT:34147029, title = {Furanonaphthoquinones, Diterpenes, and Flavonoids from Sweet Marjoram and Investigation of Antimicrobial, Bacterial Efflux, and Biofilm Formation Inhibitory Activities}, url = {https://m2.mtmt.hu/api/publication/34147029}, author = {Abu Ghazal, Tasneem and Veres, Katalin and Vidács, Lívia Melinda and Szemerédi, Nikoletta and Spengler, Gabriella and Berkecz, Róbert and Hohmann, Judit}, doi = {10.1021/acsomega.3c03982}, journal-iso = {ACS OMEGA}, journal = {ACS OMEGA}, volume = {8}, unique-id = {34147029}, issn = {2470-1343}, year = {2023}, eissn = {2470-1343}, pages = {34816-34825}, orcid-numbers = {Abu Ghazal, Tasneem/0000-0003-1574-5948; Veres, Katalin/0000-0001-7108-3622; Spengler, Gabriella/0000-0001-8085-0950; Berkecz, Róbert/0000-0002-9076-2177; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:34006534, title = {Effect of Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones in the Virulence of Resistant Bacteria}, url = {https://m2.mtmt.hu/api/publication/34006534}, author = {Almeida, M.C. and Szemerédi, Nikoletta and Durães, F. and Long, S. and Resende, D.I.S.P. and Martins, da Costa P. and Pinto, M. and Spengler, Gabriella and Sousa, E.}, doi = {10.3390/antibiotics12050922}, journal-iso = {ANTIBIOTICS-BASEL}, journal = {ANTIBIOTICS}, volume = {12}, unique-id = {34006534}, abstract = {Drug resistance is rising to alarming levels, constituting one of the major threats to global health. The overexpression of efflux pumps and the formation of biofilms constitute two of the most common resistance mechanisms, favoring the virulence of bacteria. Therefore, the research and development of effective antimicrobial agents that can also counteract resistance mechanisms are extremely important. Pyrazino[2,1-b]quinazoline-3,6-diones, from marine and terrestrial organisms and simpler synthetic analogues, were recently disclosed by us as having relevant antimicrobial properties. In this study, using a multi-step approach, it was possible to synthesize new pyrazino[2,1-b]quinazoline-3,6-diones focusing on compounds with fluorine substituents since, to the best of our knowledge, the synthesis of fluorinated fumiquinazoline derivatives had not been attempted before. The new synthesized derivatives were screened for antibacterial activity and, along with previously synthetized pyrazino[2,1-b]quinazoline-3,6-diones, were characterized for their antibiofilm and efflux-pump-inhibiting effects against representative bacterial species and relevant resistant clinical strains. Several compounds showed relevant antibacterial activity against the tested Gram-positive bacterial species with MIC values in the range of 12.5–77 μM. Furthermore, some derivatives showed promising results as antibiofilm agents in a crystal violet assay. The results of the ethidium bromide accumulation assay suggested that some compounds could potentially inhibit bacterial efflux pumps. © 2023 by the authors.}, keywords = {ARTICLE; MOUSE; ANTIBACTERIAL; high performance liquid chromatography; Escherichia coli; controlled study; nonhuman; animal experiment; animal cell; CRYSTALLIZATION; Mass spectrometry; unclassified drug; minimum inhibitory concentration; Thin layer chromatography; drug structure; doxorubicin; fluorine; antiinfective agent; Staphylococcus aureus; tripeptide; ANTIMICROBIAL ACTIVITY; antibacterial activity; Biofilm; Enterococcus faecalis; Antibiotic resistance; bacterial virulence; structure activity relation; drug synthesis; proton nuclear magnetic resonance; fluorescence analysis; disk diffusion; quinazoline derivative; indole derivative; carbonyl cyanide chlorophenylhydrazone; heteronuclear single quantum coherence; quadrupole mass spectrometry; Efflux pump inhibition; IC50; NIH 3T3 cell line; Antibiofilm; vancomycin resistant Enterococcus; antibiofilm activity; Zone of inhibition; chromatography by mobile phase; multidrug resistant bacterium; Acid chloride; crystal violet assay; pyrazino[2,1-b]quinazoline-3,6-diones; ((1s,4s) 8,10 dichloro 4 ((6 fluoro 1h indol 3 yl)methyl) 1 isobutyl 1,2 dihydro 6h pyrazino[2,1 b]quinazoline 3,6(4h) dione; (1s,4R) 4 ((1h indol 3 yl)methyl) 1 methyl 1,2 dihydro 6h pyrazino[2,1 b]quinazoline 3,6(4h) dione (2, fumiquinazoline f); (1s,4R) 4 ((1h Indol 3 yl)methyl) 8 fluoro 1 isobutyl 1,2 dihydro 6h pyrazino[2,1 b]quinazoline 3,6(4h) dione; (1s,4R) 4 ((1h indol 3 yl)methyl) 8 fluoro 1 isobutyl 1,2 dihydro 6h pyrazino[2,1 b] quinazoline 3,6(4h) dione; (1s,4R) 4 ((1h indol 3 yl)methyl) 9 fluoro 1 isobutyl 1,2 dihydro 6h pyrazino[2,1 b] quinazoline 3,6(4h) dione; (1s,4s) 8,10 dichloro 4 ((7 chloro 1h indol 3 yl)methyl) 1 isobutyl 1,2 dihydro 6h pyrazino[2,1 b]quinazoline 3,6(4h) dione; (R) 4 ((1h Indol 3 yl)methyl) 1,2 dihydro 6h pyrazino[2,1 b] quinazoline 3,6(4h) dione (1, glyantrypine); (R) 4 ((1h indol 3 yl)methyl) 1,2 dihydro 6h pyrazino[2,1 b]quinazoline 3,6(4h) dione (1, glyantrypine); (s) 2 (2 amino 3,5 dichlorobenzamido) 3 (6 fluoro 1h indol 3 yl)propanoate; (s) 2 (2 amino 3,5 dichlorobenzamido) 3 (7 chloro 1h indol 3 yl)propanoate; alkaloid ((1s,4s) 8,10 dichloro 4 ((6 fluoro 1h indol 3 yl)methyl) 1 isobutyl 1,2 dihydro 6h pyrazino[2,1 b]quinazoline 3,6(4h) dione; alkaloid (1s,4R) 4 ((1h Indol 3 yl)methyl) 9 fluoro 1 isobutyl 1,2 dihydro 6h pyrazino[2,1 b]quinazoline 3,6(4h) dione; dipeptide methyl (2 amino 4 fluorobenzoyl) d tryptophanate; dipeptide methyl (2 amino 5 fluorobenzoyl) d tryptophanate; fmoc gly cl; fmoc l ala cl; fmoc l leu cl; fumiquinazoline A; fumiquinazoline F; fumiquinazoline G; glyantrypine; indole containing pyrazino[2,1 b]quinazoline 3,6 diones; linear dipeptide; methyl (2 ((s) 2 ((((9h fluoren 9 yl)methoxy)carbonyl)amino) 4 methylpentanamido) 5 fluorobenzoyl) d tryptophanate; methyl (2 ((s) 2 ((((9h fluoren 9 yl)methoxy)carbonyl)amino) 4 methylpentanamido) 4 fluorobenzoyl) d tryptophanate; methyl (2 ((s) 2 ((((9h fluoren 9 yl)methoxy)carbonyl)amino) 4 methylpentanamido) 4 fluorobenzoyl) d tryptophanate; methyl (2 ((s) 2 ((((9h fluoren 9 yl)methoxy)carbonyl)amino)propanamido) benzoyl) d tryptophanate; methyl (2 ((s) 2 ((((9h fluoren 9 yl)methoxy)carbonyl)amino)propanamido) benzoyl) d tryptophanate; methyl (2 (2 ((((9h fluoren 9 yl)methoxy)carbonyl)amino)acetamido) benzoyl) d tryptophanate; methyl (2 amino 4 fluorobenzoyl) d tryptophanate; methyl (2 amino 5 fluorobenzoyl) d tryptophanate; methyl (2 aminobenzoyl) d tryptophanate; methyl (s) 2 (2 ((s) 2 ((((9h fluoren 9 yl)methoxy)carbonyl)amino) 4 methylpentanamido) 3,5 dichlorobenzamido) 3 (6 fluoro 1h indol 3 yl)propanoate; methyl (s) 2 (2 amino 3,5 dichlorobenzamido) 3 (7 chloro 1h indol 3 yl)propanoate; methyl (s) 2 amino 3 (7 chloro 1h indol 3 yl)propanoate; methyl (s)2 amino 3 (6 fluoro 1h indol 3 yl)propanoate; neofiscalin A; tripeptide methyl (s) 2 (2 ((s) 2 ((((9h fluoren 9 yl)methoxy)carbonyl) amino) 4 methylpentanamido) 3,5 dichlorobenzamido) 3 (7 chloro 1h indol 3 yl)propanoate; tryptophan methyl esters hydrochloride; ethidium bromide accumulation assay; vancomycin resistant Enterococcus faecalis}, year = {2023}, eissn = {2079-6382}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @book{MTMT:34747744, title = {ORVOSI MIKROBIOLÓGIA. Gyakorlati jegyzet I-II. kötet}, url = {https://m2.mtmt.hu/api/publication/34747744}, isbn = {9789633069332}, author = {Burián, Katalin and Endrész, Valéria and Megyeri, Klára and Mosolygó, Tímea and Orosz, László and Somogyvári, Ferenc and Spengler, Gabriella and Bogdanov, Anita and Virók, Dezső}, editor = {Burián, Katalin}, publisher = {SZTE SZAOK Orvosi Mikrobiológiai Intézet}, unique-id = {34747744}, year = {2023}, orcid-numbers = {Burián, Katalin/0000-0003-1300-2374; Endrész, Valéria/0000-0002-9402-3857; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950; Bogdanov, Anita/0000-0003-3067-8835; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:33208800, title = {Ruthenium(II) polypyridyl complexes with benzothiophene and benzimidazole derivatives: Synthesis, antitumor activity, solution studies and biospeciation}, url = {https://m2.mtmt.hu/api/publication/33208800}, author = {Dömötör, Orsolya and Teixeira, Ricardo G. and Spengler, Gabriella and Avecilla, Fernando and Marques, Fernanda and Lenis-Rojas, Oscar A. and Matos, Cristina P. and de Almeida, Rodrigo F.M. and Enyedy, Éva Anna and Tomaz, Ana Isabel}, doi = {10.1016/j.jinorgbio.2022.112058}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {238}, unique-id = {33208800}, issn = {0162-0134}, year = {2023}, eissn = {1873-3344}, orcid-numbers = {Dömötör, Orsolya/0000-0001-8736-3215; Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128} } @CONFERENCE{MTMT:33963567, title = {Investigation of antimicrobial and antitumor properties of selectedEuphorbiaceae species}, url = {https://m2.mtmt.hu/api/publication/33963567}, author = {Wirasisya, Dyke Gita and Barta, Anita and Spengler, Gabriella and Krystic, Gordana and Mertha, Gde and Hohmann, Judit}, booktitle = {4th Symposium of Young Researchers on Pharmacognosy}, doi = {10.14232/syrmpnpr.2023.13}, unique-id = {33963567}, year = {2023}, pages = {20-20}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Krystic, Gordana/0000-0001-6945-6178; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:34139861, title = {Polyporenic Acids from the Mushroom Buglossoporus quercinus Possess Chemosensitizing and Efflux Pump Inhibitory Activities on Colo 320 Adenocarcinoma Cells}, url = {https://m2.mtmt.hu/api/publication/34139861}, author = {Felegyi, Kristóf and Garádi, Zsófia and Rácz, Bálint and Tóth, Gábor and Papp, Viktor and Boldizsár, Imre and Dancsó, András and Spengler, Gabriella and Béni, Szabolcs and Ványolós, Attila}, doi = {10.3390/jof9090923}, journal-iso = {J FUNGI}, journal = {JOURNAL OF FUNGI}, volume = {9}, unique-id = {34139861}, year = {2023}, eissn = {2309-608X}, orcid-numbers = {Garádi, Zsófia/0000-0002-0152-2746; Rácz, Bálint/0000-0003-0088-3408; Boldizsár, Imre/0000-0001-7852-8364; Dancsó, András/0000-0001-8460-217X; Spengler, Gabriella/0000-0001-8085-0950; Béni, Szabolcs/0000-0001-7056-6825; Ványolós, Attila/0000-0002-4710-0004} } @article{MTMT:33742452, title = {Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines}, url = {https://m2.mtmt.hu/api/publication/33742452}, author = {Ferencz, Elek and Spengler, Gabriella and Zupkó, István and Vollár, Martin and Zomborszki, Zoltán Péter and Kúsz, Norbert and Hohmann, Judit and Kovács, Balázs and Csupor, Dezső and Laczkó-Zöld, Eszter and Csupor-Löffler, Boglárka}, doi = {10.1515/znc-2022-0239}, journal-iso = {Z NATURFORSCH C}, journal = {ZEITSCHRIFT FÜR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES}, volume = {78}, unique-id = {33742452}, issn = {0939-5075}, abstract = {Common ragweed (Ambrosia artemisiifolia L.) is an invasive plant in Europe with spreading use in the contemporary folk medicine. The chemical composition of the above-ground parts is extensively studied, however, the metabolites of the roots are less discovered. By multiple chromatographic purification of the root extracts, we isolated thiophene A (1), n-dodecene (2), taraxerol-3-O-acetate (3), α-linoleic acid (4), (+)-pinoresinol (5), and thiophene E (7,10-epithio-7,9-tridecadiene-3,5,11-triyne-1,2-diol) (6). The 1H NMR data published earlier for 1 were supplemented together with the assignment of 13C NMR data. Thiophene E (6), which is reported for the first time from this species, exerted cytotoxic and antiproliferative effects on A-431 epidermoid skin cancer cells, whereas taraxerol-3-O-acetate (3) and α-linoleic acid (4) had slight antiproliferative effect on gynecological cancer cell lines. Thiophene E (6) and taraxerol-3-O-acetate (3) displayed antiproliferative and cytotoxic effects on MRC-5 fibroblast cells. Thiophene E (6) exerted weak antibacterial activity (MIC 25 μg/mL) on MRSA ATCC 43300, on Staphylococcus aureus ATCC 25923, Escherichia coli AG100 and E. coli ATCC 25922 both thiophenes were inactive. Although the isolated compounds exerted no remarkable cytotoxic or antiproliferative activities, the effects on MRC-5 fibroblast cells highlight the necessity of further studies to support the safety of ragweed root.}, keywords = {lignan; RAGWEED; Thiophene; Ambrosia artemisiifolia; sterol}, year = {2023}, eissn = {1865-7125}, pages = {299-305}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Zupkó, István/0000-0003-3243-5300; Zomborszki, Zoltán Péter/0000-0002-7412-9793; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:34109620, title = {Organorhodium complexes of 8-hydroxyquinoline derivatives with antibacterial and antitumor effect}, url = {https://m2.mtmt.hu/api/publication/34109620}, author = {Spengler, Gabriella and Pivarcsik, Tamás and Gergő, Egri and Ugrai, Imre and Szatmári, István and Enyedy, Éva Anna}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {70}, unique-id = {34109620}, issn = {1217-8950}, year = {2023}, eissn = {1588-2640}, pages = {81-82}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Szatmári, István/0000-0002-8571-5229; Enyedy, Éva Anna/0000-0002-8058-8128} } @book{MTMT:34747796, title = {MEDICAL MICROBIOLOGY. Practical classes}, url = {https://m2.mtmt.hu/api/publication/34747796}, isbn = {9789633069325}, author = {Burián, Katalin and Endrész, Valéria and Megyeri, Klára and Mosolygó, Tímea and Orosz, László and Somogyvári, Ferenc and Spengler, Gabriella and Bogdanov, Anita and Virók, Dezső}, editor = {Burián, Katalin}, publisher = {SZTE SZAOK Orvosi Mikrobiológiai Intézet}, unique-id = {34747796}, year = {2023}, orcid-numbers = {Burián, Katalin/0000-0003-1300-2374; Endrész, Valéria/0000-0002-9402-3857; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950; Bogdanov, Anita/0000-0003-3067-8835; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:34109493, title = {Anticancer activity of symmetrical selenoesters on breast cancer cell lines}, url = {https://m2.mtmt.hu/api/publication/34109493}, author = {Kristóf, Erzsébet and Rácz, Bálint and Szemerédi, Nikoletta and Dominguez-Álvarez, Enrique and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {70}, unique-id = {34109493}, issn = {1217-8950}, year = {2023}, eissn = {1588-2640}, pages = {31-31}, orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:33946542, title = {Modulation of the bacterial virulence and resistance by well-known European medicinal herbs}, url = {https://m2.mtmt.hu/api/publication/33946542}, author = {Krizkovska, Bara and Hoang, Lan and Brdova, Daniela and Klementova, Kristyna and Szemerédi, Nikoletta and Louckova, Anna and Kronusova, Olga and Spengler, Gabriella and Kastanek, Petr and Hajslova, Jana and Viktorova, Jitka and Lipov, Jan}, doi = {10.1016/j.jep.2023.116484}, journal-iso = {J ETHNOPHARMACOL}, journal = {JOURNAL OF ETHNOPHARMACOLOGY}, volume = {312}, unique-id = {33946542}, issn = {0378-8741}, abstract = {Ethnopharmacological relevance: Salvia officinalis L., Sambucus nigra L., Matricaria chamomilla L., Agrimonia eupatoria L., Fragaria vesca L. and Malva sylvestris L. are plants that have a long tradition in European folk medicine. To this day, they are part of medicinal teas or creams that help with the healing of skin wounds and the treatment of respiratory or intestinal infections. However, so far these plants have not been investigated more deeply than in their direct antibacterial effect.Aim of the study: Our research is focused on adjuvants that inhibit the mechanism of antibiotic resistance or modulate bacterial virulence. Based on a preliminary screening of 52 European herbs, which commonly appear as part of tea blends or poultice. Six of them were selected for their ability to revert the resistant phenotype of nosocomial bacterial strains.Methods: Herbs selected for this study were obtained from commercially available sources. For the extraction of active compounds ethanol was used. Modulation of virulence was observed as an ability to inhibit bacterial cellto-cell communication using two mutant sensor strains of Vibrio campbellii. Biofilm formation, and planktonic cell adhesion was measured using a static antibiofilm test. Ethidium bromide assay was used to checked the potential of inhibition bacterial efflux pumps. The antibacterial activities of the herbs were evaluated against resistant bacterial strains using macro dilution methods.Results: Alcohol extracts had antibacterial properties mainly against Gram-positive bacteria. Of all of them, the highest antimicrobial activity demonstrated Malva sylvestris, killing both antibiotic resistant bacteria; Staphylococcus aureus with MIC of 0.8 g/L and Pseudomonas aeruginosa 0.7 g/L, respectively. Fragaria vesca extract (0.08 g/L) demonstrated strong synergism with colistin (4 mg/L) in modulating the resistant phenotype to colistin of Pseudomonas aeruginosa. Similarly, the extract of S. officinalis (0.21 g/L) reverted resistance to gentamicin (1 mg/ L) in S. aureus. However, Sambucus nigra and Matricaria chamomilla seem to be a very promising source of bacterial efflux pump inhibitors.Conclusion: The extract of F. vesca was the most active. It was able to reduce biofilm formation probably due to the ability to decrease bacterial quorum sensing. On the other hand, the activity of S. nigra or M. chamomilla in reducing bacterial virulence may be explained by the ability to inhibit bacterial efflux systems. All these plants have potential as an adjuvant for the antibiotic treatment.}, keywords = {herbs; multidrug resistance; medicinal plants; Biofilm; quorum sensing; Efflux pump inhibitors}, year = {2023}, eissn = {1872-7573}, orcid-numbers = {Krizkovska, Bara/0000-0002-9534-0037; Louckova, Anna/0000-0002-5675-961X; Kronusova, Olga/0000-0002-4269-8529; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:33744665, title = {A comparative study on the metal complexes of an anticancer estradiol-hydroxamate conjugate and salicylhydroxamic acid}, url = {https://m2.mtmt.hu/api/publication/33744665}, author = {Mészáros, János Péter and Kovács, Hilda and Spengler, Gabriella and Kovács, Ferenc and Nagyné Frank, Éva and Enyedy, Éva Anna}, doi = {10.1016/j.jinorgbio.2023.112223}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {244}, unique-id = {33744665}, issn = {0162-0134}, year = {2023}, eissn = {1873-3344}, orcid-numbers = {Mészáros, János Péter/0000-0001-6301-5259; Spengler, Gabriella/0000-0001-8085-0950; Nagyné Frank, Éva/0000-0002-1332-0551; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:33590772, title = {Half-Sandwich Rhodium Complexes with Releasable N-Donor Monodentate Ligands: Solution Chemical Properties and the Possibility for Acidosis Activation}, url = {https://m2.mtmt.hu/api/publication/33590772}, author = {Mészáros, János Péter and Kandioller, Wolfgang and Spengler, Gabriella and Prado-Roller, Alexander and Keppler, Bernhard K. and Enyedy, Éva Anna}, doi = {10.3390/pharmaceutics15020356}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {15}, unique-id = {33590772}, issn = {1999-4923}, abstract = {Cancer chemotherapeutics usually have serious side effects. Targeting the special properties of cancer and activation of the anticancer drug in the tumor microenvironment in situ may decrease the intensity of the side effects and improve the efficacy of therapy. In this study, half-sandwich Rh complexes are introduced, which may be activated at the acidic, extracellular pH of the tumor tissue. The synthesis and aqueous stability of mixed-ligand complexes with a general formula of [Rh(η5-Cp*)(N,N/O)(N)]2+/+ are reported, where (N,N/O) indicates bidentate 8-quinolate, ethylenediamine and 1,10-phenanthroline and (N) represents the releasable monodentate ligand with a nitrogen donor atom. UV-visible spectrophotometry, 1H NMR, and pH-potentiometry were used to determine the protonation constants of the monodentate ligands, the proton dissociation constants of the coordinated water molecules in the aqua complexes, and the formation constants of the mixed-ligand complexes. The obtained data were compared to those of the analogous Ru(η6-p-cymene) complexes. The developed mixed-ligand complexes were tested in drug-sensitive and resistant colon cancer cell lines (Colo205 and Colo320, respectively) and in four bacterial strains (Gram-positive and Gram-negative, drug-sensitive, and resistant) at different pH values (5–8). The mixed-ligand complexes with 1-methylimidazole displayed sufficient stability at pH 7.4, and their activation was found in cancer cells with decreasing pH; moreover, the mixed-ligand complexes demonstrated antimicrobial activity in Gram-positive and Gram-negative bacteria, including the resistant MRSA strain. This study proved the viability of incorporating releasable monodentate ligands into mixed-ligand half-sandwich complexes, which is supported by the biological assays.}, year = {2023}, eissn = {1999-4923}, orcid-numbers = {Mészáros, János Péter/0000-0001-6301-5259; Kandioller, Wolfgang/0000-0002-5630-712X; Spengler, Gabriella/0000-0001-8085-0950; Prado-Roller, Alexander/0000-0002-3719-801X; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:34109606, title = {Reversal of multidrug resistance by selenocompounds in 2D and 3D tumor cell cultures}, url = {https://m2.mtmt.hu/api/publication/34109606}, author = {Szemerédi, Nikoletta and Simona, Dobiasova and Jitka, Viktorova and Helena, Gbelcova and Enrique, Domingez-Álvarez and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {70}, unique-id = {34109606}, issn = {1217-8950}, year = {2023}, eissn = {1588-2640}, pages = {44-44}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:33416616, title = {Estradiol-Based Salicylaldehyde (Thio)semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities}, url = {https://m2.mtmt.hu/api/publication/33416616}, author = {Petrasheuskaya, Tatsiana and Kovács, Ferenc and Igaz, Nóra and Rónavári, Andrea and Hajdu, Bálint and Nagyné Bereczki, Laura and May, Nóra Veronika and Spengler, Gabriella and Gyurcsik, Béla and Csontné Kiricsi, Mónika and Nagyné Frank, Éva and Enyedy, Éva Anna}, doi = {10.3390/molecules28010054}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {28}, unique-id = {33416616}, issn = {1420-3049}, abstract = {A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and ¹³C nuclear magnetic resonance spectroscopy, UV–visible and electron paramagnetic resonance spectroscopy, electrospray ionization mass spectrometry and elemental analysis. The structure of the Cu(II)-estradiol-semicarbazone complex was revealed by X-ray crystallography. Proton dissociation constants of the ligands and stability constants of the metal complexes were determined in 30% (v/v) DMSO/H2O. Estradiol-(T)SCs form mono-ligand complexes with Cu(II) ions and exhibit high stability with the exception of estradiol-SC. The Cu(II) complexes of estradiol-TSC and its N,N-dimethyl derivative displayed the highest cytotoxicity among the tested compounds in MCF-7, MCF-7 KCR, DU-145, and A549 cancer cells. The complexes do not damage DNA according to both in vitro cell-free and cellular assays. All the Cu(II)-TSC complexes revealed significant activity against the Gram-positive Staphylococcus aureus bacteria strain. Estradiol-TSCs showed efficient antioxidant activity, which was decreased by complexation with Cu(II) ions. The exchange of estrone moiety to estradiol did not result in significant changes to physico-chemical and biological properties.}, year = {2023}, eissn = {1420-3049}, orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Gyurcsik, Béla/0000-0003-1894-7414; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Nagyné Frank, Éva/0000-0002-1332-0551; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:34192715, title = {Iron(II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: Ethylenebis(diphenylphosphane) vs. triphenylphosphane}, url = {https://m2.mtmt.hu/api/publication/34192715}, author = {Pilon, Adhan and Avecilla, Fernando and Rácz, Bálint and Gátszegi, Gerda T. and Spengler, Gabriella and Robalo, M. Paula and Enyedy, Éva Anna and Garcia, M. Helena and Valente, Andreia}, doi = {10.1016/j.jinorgbio.2023.112386}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {249}, unique-id = {34192715}, issn = {0162-0134}, year = {2023}, eissn = {1873-3344}, orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:33800320, title = {First iron(II) organometallic compound acting as ABCB1 inhibitor}, url = {https://m2.mtmt.hu/api/publication/33800320}, author = {Pilon, Adhan and Avecilla, Fernando and Mohai, Miklós Péter and Enyedy, Éva Anna and Rácz, Bálint and Spengler, Gabriella and Garcia, M. Helena and Valente, Andreia}, doi = {10.1016/j.ejmech.2023.115466}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {256}, unique-id = {33800320}, issn = {0223-5234}, abstract = {Appendix A. Supplementary data: Supplementary data to this article can be found online at https://doi. org/10.1016/j.ejmech.2023.115466}, year = {2023}, eissn = {1768-3254}, orcid-numbers = {Enyedy, Éva Anna/0000-0002-8058-8128; Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950; Valente, Andreia/0000-0002-3370-208X} } @article{MTMT:33532438, title = {Metal Complexes of a 5-Nitro-8-Hydroxyquinoline-Proline Hybrid with Enhanced Water Solubility Targeting Multidrug Resistant Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/33532438}, author = {Pivarcsik, Tamás and Pósa, Vivien and Kovács, Hilda and May, Nóra Veronika and Spengler, Gabriella and Pósa, Szonja P. and Tóth, Szilárd and Nezafat Yazdi, Zeinab and Laczka, Csilla and Ugrai, Imre and Szatmári, István and Szakács, Gergely and Enyedy, Éva Anna}, doi = {10.3390/ijms24010593}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {33532438}, issn = {1661-6596}, abstract = {Multidrug resistance (MDR) in cancer is one of the major obstacles of chemotherapy. We have recently identified a series of 8-hydroxyquinoline Mannich base derivatives with MDR-selective toxicity, however with limited solubility. In this work, a novel 5-nitro-8-hydroxyquinoline-proline hybrid and its Rh(η5-C5Me5) and Ru(η6-p-cymene) complexes with excellent aqueous solubility were developed, characterized, and tested against sensitive and MDR cells. Complex formation of the ligand with essential metal ions was also investigated using UV-visible, circular dichroism, 1H NMR (Zn(II)), and electron paramagnetic resonance (Cu(II)) spectroscopic methods. Formation of mono and bis complexes was found in all cases with versatile coordination modes, while tris complexes were also formed with Fe(II) and Fe(III) ions, revealing the metal binding affinity of the ligand at pH 7.4: Cu(II) > Zn(II) > Fe(II) > Fe(III). The ligand and its Rh(III) complex displayed enhanced cytotoxicity against the resistant MES-SA/Dx5 and Colo320 human cancer cell lines compared to their chemosensitive counterparts. Both organometallic complexes possess high stability in solution, however the Ru(II) complex has lower chloride ion affinity and slower ligand exchange processes, along with the readiness to lose the arene ring that is likely connected to its inactivity.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Pósa, Szonja P./0000-0002-7535-9689; Szatmári, István/0000-0002-8571-5229; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:34231319, title = {Antitumor Activity of Symmetrical Selenoesters in Doxorubicin Resistant Breast Cancer}, url = {https://m2.mtmt.hu/api/publication/34231319}, author = {Rácz, Bálint and Kristof, Erzsebet and Kincses, Annamária and Dominguez-Alvarez, Enrique and Spengler, Gabriella}, doi = {10.21873/anticanres.16683}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {43}, unique-id = {34231319}, issn = {0250-7005}, year = {2023}, eissn = {1791-7530}, pages = {4865-4872}, orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:33641641, title = {Reversal of Multidrug Resistance by Symmetrical Selenoesters in Colon Adenocarcinoma Cells}, url = {https://m2.mtmt.hu/api/publication/33641641}, author = {Rácz, Bálint and Kincses, Annamária and Laczi, Krisztián and Rákhely, Gábor and Domínguez-Álvarez, Enrique and Spengler, Gabriella}, doi = {10.3390/pharmaceutics15020610}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {15}, unique-id = {33641641}, issn = {1999-4923}, abstract = {Recently, selenium containing derivatives have attracted more attention in medicinal chemistry. In the present work, the anticancer activity of symmetrical selenoesters was investigated by studying the reversal of efflux pump-related and apoptosis resistance in sensitive and resistant human colon adenocarcinoma cells expressing the ABCB1 protein. The combined effect of the compounds with doxorubicin was demonstrated with a checkerboard assay. The ABCB1 inhibitory and the apoptosis-inducing effects of the derivatives were measured with flow cytometry. Whole transcriptome sequencing was carried out on Illumina platform upon the treatment of resistant cells with the most potent derivatives. One ketone and three methyl ester selenoesters showed synergistic or weak synergistic interaction with doxorubicin, respectively. Ketone selenoesters were the most potent ABCB1 inhibitors and apoptosis inducers. Nitrile selenoesters could induce moderate early and late apoptotic processes that could be explained by their ABCB1 modulating properties. The transcriptome analysis revealed that symmetrical selenoesters may influence the redox state of the cells and interfere with metastasis formation. It can be assumed that these symmetrical selenocompounds possess toxic, DNA-damaging effects due to the presence of two selenium atoms in the molecule, which may be augmented by the presence of symmetrical groups.}, year = {2023}, eissn = {1999-4923}, orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Kincses, Annamária/0000-0002-1591-1419; Laczi, Krisztián/0000-0002-9399-7406; Rákhely, Gábor/0000-0003-2557-3641; Domínguez-Álvarez, Enrique/0000-0003-2655-1575; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:33558152, title = {Repurposing Antidepressants and Phenothiazine Antipsychotics as Efflux Pump Inhibitors in Cancer and Infectious Diseases}, url = {https://m2.mtmt.hu/api/publication/33558152}, author = {Rácz, Bálint and Spengler, Gabriella}, doi = {10.3390/antibiotics12010137}, journal-iso = {ANTIBIOTICS-BASEL}, journal = {ANTIBIOTICS}, volume = {12}, unique-id = {33558152}, abstract = {Multidrug resistance (MDR) is a major obstacle in the therapy of infectious diseases and cancer. One of the major mechanisms of MDR is the overexpression of efflux pumps (EPs) that are responsible for extruding antimicrobial and anticancer agents. EPs have additional roles of detoxification that may aid the development of bacterial infection and the progression of cancer. Therefore, targeting EPs may be an attractive strategy to treat bacterial infections and cancer. The development and discovery of a new drug require a long timeline and may come with high development costs. A potential alternative to reduce the time and costs of drug development is to repurpose already existing drugs. Antidepressants and antipsychotic agents are widely used in clinical practice in the treatment of psychiatric disorders and some somatic diseases. Antidepressants and antipsychotics have demonstrated various beneficial activities that may be utilized in the treatment of infections and cancer. This review aims to provide a brief overview of antibacterial and anticancer effects of selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs) and phenothiazine antipsychotics, while focusing on EPs. However, it should be noted that the antimicrobial activity of a traditionally non-antibiotic drug may have clinical implications regarding dysbiosis and bacterial MDR.}, year = {2023}, eissn = {2079-6382}, orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:33708889, title = {Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) complexes}, url = {https://m2.mtmt.hu/api/publication/33708889}, author = {Ribeiro, Nádia and Bulut, Ipek and Sergi, Baris and Pósa, Vivien and Spengler, Gabriella and Sciortino, Giuseppe and André, Vânia and Ferreira, Liliana P. and Biver, Tarita and Ugone, Valeria and Garribba, Eugenio and Costa-Pessoa, João and Enyedy, Éva Anna and Acilan, Ceyda and Correia, Isabel}, doi = {10.3389/fchem.2023.1106349}, journal-iso = {FRONT CHEM}, journal = {FRONTIERS IN CHEMISTRY}, volume = {11}, unique-id = {33708889}, issn = {2296-2646}, abstract = {We report the synthesis and characterization of a group of benzoylhydrazones (L n ) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH 3 , OCH 3 , OH and NH 2 , for L 1-7 , respectively; in L 8 isonicotinohydrazide was used instead of benzylhydrazide). Cu(II) complexes were prepared by reaction of each benzoylhydrazone with Cu(II) acetate. All compounds were characterized by elemental analysis and mass spectrometry as well as by FTIR, UV-visible absorption, NMR or electron paramagnetic resonance spectroscopies. Complexes isolated in the solid state ( 1–8 ) are either formulated as [Cu(HL)acetate] (with L 1 and L 4 ) or as [Cu(L n )] 3 ( n = 2, 3, 5, 6, 7 and 8). Single crystal X-ray diffraction studies were done for L 5 and [Cu(L 5 )] 3 , confirming the trinuclear formulation of several complexes. Proton dissociation constants, lipophilicity and solubility were determined for all free ligands by UV-Vis spectrophotometry in 30% (v/v) DMSO/H 2 O. Formation constants were determined for [Cu(LH)], [Cu(L)] and [Cu(LH −1 )] for L = L 1 , L 5 and L 6 , and also [Cu(LH −2 )] for L = L 6 , and binding modes are proposed, [Cu(L)] predominating at physiological pH. The redox properties of complexes formed with L 1 , L 5 and L 6 are investigated by cyclic voltammetry; the formal redox potentials fall in the range of +377 to +395 mV vs. NHE. The binding of the Cu(II)-complexes to bovine serum albumin was evaluated by fluorescence spectroscopy, showing moderate-to-strong interaction and suggesting formation of a ground state complex. The interaction of L 1 , L 3 , L 5 and L 7 , and of the corresponding complexes with calf thymus DNA was evaluated by thermal denaturation. The antiproliferative activity of all compounds was evaluated in malignant melanoma (A-375) and lung (A-549) cancer cells. The complexes show higher activity than the corresponding free ligand, and most complexes are more active than cisplatin. Compounds 1, 3, 5 , and 8 were selected for additional studies: while these complexes induce reactive oxygen species and double-strand breaks in both cancer cells, their ability to induce cell-death by apoptosis varies. Within the set of compounds tested, 8 emerges as the most promising one, presenting low IC 50 values, and high induction of oxidative stress and DNA damage, which eventually lead to high rates of apoptosis.}, year = {2023}, eissn = {2296-2646}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:33578997, title = {Lycorine Carbamate Derivatives for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Human Colon Adenocarcinoma Cells}, url = {https://m2.mtmt.hu/api/publication/33578997}, author = {Sancha, Shirley A. R. and Szemerédi, Nikoletta and Spengler, Gabriella and Ferreira, Maria-José U.}, doi = {10.3390/ijms24032061}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {33578997}, issn = {1661-6596}, abstract = {Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. Aiming at generating a small library of anticancer compounds for overcoming MDR, lycorine (1), a major Amaryllidaceae alkaloid isolated from Pancratium maritimum, was derivatized. Thirty-one new compounds (2–32) were obtained by chemical transformation of the hydroxyl groups of lycorine into mono- and di-carbamates. Compounds 1–32 were evaluated as MDR reversers, through the rhodamine-123 accumulation assay by flow cytometry and chemosensitivity assays, in resistant human colon adenocarcinoma cancer cells (Colo 320), overexpressing P-glycoprotein (P-gp, ABCB1). Significant inhibition of P-gp efflux activity was observed for the di-carbamate derivatives, mainly those containing aromatic substituents, at non-cytotoxic concentrations. Compound 5, bearing a benzyl substituent, and compounds 9 and 25, with phenethyl moieties, were among the most active, exhibiting strong inhibition at 2 µM, being more active than verapamil at 10-fold higher concentration. In drug combination assays, most compounds were able to synergize doxorubicin. Moreover, some derivatives showed a selective antiproliferative effect toward resistant cells, having a collateral sensitivity effect. In the ATPase assay, selected compounds (2, 5, 9, 19, 25, and 26) were shown to behave as inhibitors.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Sancha, Shirley A. R./0000-0003-3333-7729; Spengler, Gabriella/0000-0001-8085-0950; Ferreira, Maria-José U./0000-0002-8742-1486} } @article{MTMT:34231130, title = {Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies}, url = {https://m2.mtmt.hu/api/publication/34231130}, author = {Teixeira, Ricardo G. and Mészáros, János Péter and Matos, Beatriz and Côrte-Real, Leonor and Xavier, Cristina P.R. and Fontrodona, Xavier and Garcia, M. Helena and Romero, Isabel and Spengler, Gabriella and Vasconcelos, M. Helena and Tomaz, Ana Isabel and Enyedy, Éva Anna and Valente, Andreia}, doi = {10.1016/j.ejmech.2023.115922}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {262}, unique-id = {34231130}, issn = {0223-5234}, year = {2023}, eissn = {1768-3254}, orcid-numbers = {Teixeira, Ricardo G./0000-0002-1028-0486; Mészáros, János Péter/0000-0001-6301-5259; Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128; Valente, Andreia/0000-0002-3370-208X} } @article{MTMT:34328388, title = {Indonesian Euphorbiaceae: Ethnobotanical Survey, In Vitro Antibacterial, Antitumour Screening and Phytochemical Analysis of Euphorbia atoto}, url = {https://m2.mtmt.hu/api/publication/34328388}, author = {Wirasisya, Dyke Gita and Kincses, Annamária and Vidács, Lívia Melinda and Szemerédi, Nikoletta and Spengler, Gabriella and Barta, Anita and Mertha, I Gde and Hohmann, Judit}, doi = {10.3390/plants12223836}, journal-iso = {PLANTS-BASEL}, journal = {PLANTS-BASEL}, volume = {12}, unique-id = {34328388}, abstract = {Indonesia is among the countries with the most significant biodiversity globally. Jamu, the traditional medicine of Indonesia, predominantly uses herbal materials and is an integral component of the Indonesian healthcare system. The present study reviewed the ethnobotanical data of seven Indonesian Euphorbiaceae species, namely Euphorbia atoto, E. hypericifolia, Homalanthus giganteus, Macaranga tanarius, Mallotus mollissimus, M. rufidulus, and Shirakiopsis indica, based on the RISTOJA database and other literature sources. An antimicrobial screening of the plant extracts was performed in 15 microorganisms using the disk diffusion and broth microdilution methods, and the antiproliferative effects were examined in drug-sensitive Colo 205 and resistant Colo 320 cells by the MTT assay. The antimicrobial testing showed a high potency of M. tanarius, H. giganteus, M. rufidulus, S. indica, and E. atoto extracts (MIC = 12.5–500 µg/mL) against different bacteria. In the antitumour screening, remarkable activities (IC50 0.23–2.60 µg/mL) were demonstrated for the extracts of H. giganteus, M. rufidulus, S. indica, and E. atoto against Colo 205 cells. The n-hexane extract of E. atoto, with an IC50 value of 0.24 ± 0.06 µg/mL (Colo 205), was subjected to multistep chromatographic separation, and 24-methylene-cycloartan-3β-ol, jolkinolide E, tetra-tert-butyl-diphenyl ether, α-tocopherol, and β-sitosterol were isolated.}, year = {2023}, eissn = {2223-7747}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:34046103, title = {Indolo[2,3-e]benzazocines and indolo[2,3-f]benzazonines and their copper(II) complexes as microtubule destabilizing agents}, url = {https://m2.mtmt.hu/api/publication/34046103}, author = {Wittmann, Christopher and Dömötör, Orsolya and Kuznetcova, Irina and Spengler, Gabriella and Reynisson, Johannes and Holder, Lauren and Miller, Gavin John and Enyedy, Éva Anna and Bai, Ruoli and Hamel, Ernest and Arion, Vladimir}, doi = {10.1039/D3DT01632C}, journal-iso = {J CHEM SOC DALTON TRANS}, journal = {JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS}, volume = {52}, unique-id = {34046103}, issn = {1472-7773}, abstract = {A series of four indolo[2,3-e]benzazocines HL1–HL4 and two indolo[2,3-f]benzazonines HL5–and HL6, as well as their respective copper(II) complexes 1–6 were synthesized and characterized by 1H and 13C NMR spectroscopy, ESI...}, year = {2023}, pages = {9964-9982}, orcid-numbers = {Dömötör, Orsolya/0000-0001-8736-3215; Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:33552540, title = {Isolation of the Lanostane Triterpenes Pholiols L–S from Pholiota populnea and Evaluation of Their Antiproliferative and Cytotoxic Activities}, url = {https://m2.mtmt.hu/api/publication/33552540}, author = {Yazdani, Morteza and Barta, Anita and Hetényi, Anasztázia and Berkecz, Róbert and Spengler, Gabriella and Ványolós, Attila and Hohmann, Judit}, doi = {10.3390/ph16010104}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {16}, unique-id = {33552540}, year = {2023}, eissn = {1424-8247}, orcid-numbers = {Hetényi, Anasztázia/0000-0001-8080-6992; Berkecz, Róbert/0000-0002-9076-2177; Spengler, Gabriella/0000-0001-8085-0950; Ványolós, Attila/0000-0002-4710-0004; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:32910919, title = {Antimicrobial, Multidrug Resistance Reversal and Biofilm Formation Inhibitory Effect of Origanum majorana Extracts, Essential Oil and Monoterpenes}, url = {https://m2.mtmt.hu/api/publication/32910919}, author = {Abu Ghazal, Tasneem and Schelz, Zsuzsanna and Vidács, Lívia Melinda and Szemerédi, Nikoletta and Veres, Katalin and Spengler, Gabriella and Hohmann, Judit}, doi = {10.3390/plants11111432}, journal-iso = {PLANTS-BASEL}, journal = {PLANTS-BASEL}, volume = {11}, unique-id = {32910919}, abstract = {Origanum majorana L. is a widely used medicinal plant; its distilled oil and preparations are extensively utilised in the phytotherapy and food industries. The objective of this study is to evaluate the extracts and the essential oil (EO) of Origanum majorana L, and its monoterpenes for antimicrobial, bacterial multidrug resistance reversing, and biofilm formation inhibitory potency. The composition of EO and n-hexane extract was characterized by GC-MS. In the essential oil terpinen-4-ol (24.92%), trans-sabinene hydrate (25.18%), gamma-terpinene (6.48%), cis-sabinene hydrate (5.44%), p-cymene (4.72%), sabinene (4.53%), alpha-terpineol (4.43%), and alpha-terpinene (3.00%) were found as the main constituents while trans-sabinene hydrate (1.43%), and terpinen-4-ol (0.19%) were detected in the n-hexane extract besides a series of hydrocarbons. The antibacterial activity of EO and terpinen-4-ol, alpha-terpinene, and linalool was also assessed against sensitive and drug-resistant S. aureus, and E. coli strains with MIC values of 0.125-0.250% and 30-61 mu M, respectively. In the efflux pump (EP) inhibitory assay, made by the ethidium bromide accumulation method in E. coli ATCC 25922, and AG100 and S. aureus ATCC 25923, and MRSA ATCC 43300 strains, EO exhibited substantial activity, especially in the E. coli ATCC 25922 strain. Among the EO constituents, only sabinene was an EP inhibitor in sensitive Escherichia strain. In the case of S. aureus strains, EO and sabinene hydrate exhibited moderate potency on the drug-resistant phenotype. The antibiofilm effects of the samples were tested by crystal violet staining at sub-MIC concentration. gamma-Terpinene, terpinen-4-ol, sabinene, sabinene hydrate and linalool were found to be effective inhibitors of biofilm formation (inhibition 36-86%) on E. coli ATCC 25922 and S. aureus MRSA ATCC 43300, while EO was ineffective on these strains. In contrast to this, biofilms formed by E. coli AG100 and S. aureus ATCC 25923 were significantly inhibited by the EO; however, it was not affected by any of the monoterpenes. This observation suggests that the antibiofilm effect might be altered by the synergism between the components of the essential oil.}, keywords = {COMPONENTS; ANTIOXIDANT; Lamiaceae; Essential oil; CHEMICAL-COMPOSITION; ANTIBIOTIC-RESISTANCE; antimicrobial effect; efflux pump inhibitor; Origanum majorana}, year = {2022}, eissn = {2223-7747}, orcid-numbers = {Abu Ghazal, Tasneem/0000-0003-1574-5948; Schelz, Zsuzsanna/0000-0002-8519-4830; Veres, Katalin/0000-0001-7108-3622; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:33150816, title = {Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma}, url = {https://m2.mtmt.hu/api/publication/33150816}, author = {Ali, Wesam and Garbo, Sabrina and Kincses, Annamária and Nové, Márta and Spengler, Gabriella and Di Bello, Elisabetta and Honkisz-Orzechowska, Ewelina and Karcz, Tadeusz and Szymańska, Ewa and Żesławska, Ewa and Starek, Małgorzata and Dąbrowska, Monika and Nitek, Wojciech and Kucwaj-Brysz, Katarzyna and Pyka, Patryk and Fioravanti, Rossella and Jacob, Claus and Battistelli, Cecilia and Zwergel, Clemens and Handzlik, Jadwiga}, doi = {10.1016/j.ejmech.2022.114761}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {243}, unique-id = {33150816}, issn = {0223-5234}, year = {2022}, eissn = {1768-3254}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Zwergel, Clemens/0000-0002-3097-0003} } @article{MTMT:33070315, title = {Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents}, url = {https://m2.mtmt.hu/api/publication/33070315}, author = {Csuvik, Oszkár and Szemerédi, Nikoletta and Spengler, Gabriella and Szatmári, István}, doi = {10.3390/ijms23179688}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {33070315}, issn = {1661-6596}, abstract = {The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1H,3H)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (mMr) applying formaldehyde and piperidine, but a second paraformaldehyde molecule was incorporated into the Mannich product. The reaction also afforded the formation of bisquinoline derivatives. A new 1H-azeto [1,2-a]quinoline derivative was synthesised in two different ways; namely starting from the aminomethylated product or from the ester-hydrolysed 4HQ. When the aldehyde component was replaced with aromatic aldehydes, Knoevenagel condensation took place affording the formation of the corresponding benzylidene derivatives, with the concomitant generation of bisquinolines. The reactivity of salicylaldehyde and hydroxynaphthaldehydes was tested; under these conditions, partially saturated lactones were formed through spontaneous ring closure. The activity of the derivatives was assessed using doxorubicin-sensitive and -resistant colon adenocarcinoma cell lines and normal human fibroblasts. Some derivatives possessed selective toxicity towards resistant cancer cells compared to doxorubicin-sensitive cancer cells and normal fibroblasts. Cytotoxic activity of the benzylidene derivatives and the corresponding Hammett–Brown substituent were correlated.}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Szatmári, István/0000-0002-8571-5229} } @article{MTMT:32820325, title = {Ketone-selenoesters as potential anticancer and multidrug resistance modulation agents in 2D and 3D ovarian and breast cancer in vitro models}, url = {https://m2.mtmt.hu/api/publication/32820325}, author = {Dobiasová, Simona and Szemerédi, Nikoletta and Kučerová, Denisa and Koucká, Kamila and Václavíková, Radka and Gbelcová, Helena and Ruml, Tomáš and Domínguez-Álvarez, Enrique and Spengler, Gabriella and Viktorová, Jitka}, doi = {10.1038/s41598-022-10311-y}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {12}, unique-id = {32820325}, issn = {2045-2322}, year = {2022}, eissn = {2045-2322}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32832029, title = {Selenium and tellurium in the development of novel small molecules and nanoparticles as cancer multidrug resistance reversal agents}, url = {https://m2.mtmt.hu/api/publication/32832029}, author = {Domínguez-Álvarez, Enrique and Rácz, Bálint and Marć, Małgorzata Anna and Nasim, Muhammad Jawad and Szemerédi, Nikoletta and Viktorová, Jitka and Jacob, Claus and Spengler, Gabriella}, doi = {10.1016/j.drup.2022.100844}, journal-iso = {DRUG RESIST UPDATE}, journal = {DRUG RESISTANCE UPDATES}, volume = {63}, unique-id = {32832029}, issn = {1368-7646}, year = {2022}, eissn = {1532-2084}, orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32753521, title = {Solution Equilibrium Studies on Salicylidene Aminoguanidine Schiff Base Metal Complexes: Impact of the Hybridization with L-Proline on Stability, Redox Activity and Cytotoxicity}, url = {https://m2.mtmt.hu/api/publication/32753521}, author = {Dömötör, Orsolya and May, Nóra Veronika and Gál, Gyula Tamás and Spengler, Gabriella and Dobrova, Aliona and Arion, Vladimir B. and Enyedy, Éva Anna}, doi = {10.3390/molecules27072044}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {27}, unique-id = {32753521}, issn = {1420-3049}, year = {2022}, eissn = {1420-3049}, orcid-numbers = {Dömötör, Orsolya/0000-0001-8736-3215; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Arion, Vladimir B./0000-0002-1895-6460; Enyedy, Éva Anna/0000-0002-8058-8128} } @CONFERENCE{MTMT:32912155, title = {Triterpén vegyületek a tölgyfa-kérgestaplóból (Buglossoporus quercinus): izolálás, szerkezetmeghatározás és biológiai aktivitás}, url = {https://m2.mtmt.hu/api/publication/32912155}, author = {Felegyi, Kristóf and Garádi, Zsófia and Rácz, Bálint and Boldizsár, Imre and Papp, Viktor and Spengler, Gabriella and Béni, Szabolcs and Ványolós, Attila}, booktitle = {Fiatal Gyógynövénykutatók Fóruma: a Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztályának rendezvénye}, doi = {10.14232/fgykf.2022.a14}, unique-id = {32912155}, year = {2022}, pages = {22-22}, orcid-numbers = {Garádi, Zsófia/0000-0002-0152-2746; Rácz, Bálint/0000-0003-0088-3408; Boldizsár, Imre/0000-0001-7852-8364; Papp, Viktor/0000-0001-6994-8156; Spengler, Gabriella/0000-0001-8085-0950; Béni, Szabolcs/0000-0001-7056-6825; Ványolós, Attila/0000-0002-4710-0004} } @article{MTMT:32824304, title = {Polyoxypregnane Ester Derivatives and Lignans from Euphorbia gossypina var. coccinea Pax.}, url = {https://m2.mtmt.hu/api/publication/32824304}, author = {Hammadi, Reham and Kúsz, Norbert and Dávid, Csilla Zsuzsanna and Mwangi, Peter Waweru and Berkecz, Róbert and Szemerédi, Nikoletta and Spengler, Gabriella and Hohmann, Judit and Vasas, Andrea}, doi = {10.3390/plants11101299}, journal-iso = {PLANTS-BASEL}, journal = {PLANTS-BASEL}, volume = {11}, unique-id = {32824304}, year = {2022}, eissn = {2223-7747}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Berkecz, Róbert/0000-0002-9076-2177; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} } @article{MTMT:32790854, title = {Application of partially aromatic ortho-quionone-methides for the synthesis of novel naphthoxazines with improved antibacterial activity}, url = {https://m2.mtmt.hu/api/publication/32790854}, author = {Hegedűs, Dóra and Szemerédi, Nikoletta and Spengler, Gabriella and Szatmári, István}, doi = {10.1016/j.ejmech.2022.114391}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {237}, unique-id = {32790854}, issn = {0223-5234}, year = {2022}, eissn = {1768-3254}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Szatmári, István/0000-0002-8571-5229} } @article{MTMT:32820336, title = {BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections}, url = {https://m2.mtmt.hu/api/publication/32820336}, author = {Jesus, Ana and Durães, Fernando and Szemerédi, Nikoletta and Freitas-Silva, Joana and da Costa, Paulo Martins and Pinto, Eugénia and Pinto, Madalena and Spengler, Gabriella and Sousa, Emília and Cidade, Honorina}, doi = {10.3390/md20050315}, journal-iso = {MAR DRUGS}, journal = {MARINE DRUGS}, volume = {20}, unique-id = {32820336}, issn = {1660-3397}, year = {2022}, eissn = {1660-3397}, orcid-numbers = {Jesus, Ana/0000-0001-7425-9750; Durães, Fernando/0000-0003-4201-2774; da Costa, Paulo Martins/0000-0001-6115-8811; Pinto, Eugénia/0000-0003-2948-5809; Pinto, Madalena/0000-0002-4676-1409; Spengler, Gabriella/0000-0001-8085-0950; Sousa, Emília/0000-0002-5397-4672; Cidade, Honorina/0000-0003-0715-1779} } @article{MTMT:33135629, title = {Coumarins, furocoumarins and limonoids of Citrus trifoliata and their effects on human colon adenocarcinoma cell lines}, url = {https://m2.mtmt.hu/api/publication/33135629}, author = {Kerekes, Diána and Horváth, Attila and Kúsz, Norbert and Borcsa, Botond Lajos and Szemerédi, Nikoletta and Spengler, Gabriella and Csupor, Dezső}, doi = {10.1016/j.heliyon.2022.e10453}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {8}, unique-id = {33135629}, year = {2022}, eissn = {2405-8440}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:33684363, title = {Antiproliferative sesquiterpene lactones from Ambrosia artemisiifolia L}, url = {https://m2.mtmt.hu/api/publication/33684363}, author = {Kovács, Balázs and Szemerédi, Nikoletta and Kúsz, Norbert and Kiss, Tivadar and Csupor-Löffler, Boglárka and Tsai, Y-C and Spengler, Gabriella and Csupor, Dezső}, doi = {10.1055/s-0042-1759242}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {88}, unique-id = {33684363}, issn = {0032-0943}, year = {2022}, eissn = {1439-0221}, pages = {1533-1533}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Kiss, Tivadar/0000-0003-3538-377X; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:33049439, title = {Antiproliferative and cytotoxic effects of sesquiterpene lactones isolated from Ambrosia artemisiifolia on human adenocarcinoma and normal cell lines}, url = {https://m2.mtmt.hu/api/publication/33049439}, author = {Kovács, Balázs and Szemerédi, Nikoletta and Kúsz, Norbert and Kiss, Tivadar and Csupor-Löffler, Boglárka and Tsai, Yu-Chi and Rácz, Bálint and Spengler, Gabriella and Csupor, Dezső}, doi = {10.1080/13880209.2022.2103574}, journal-iso = {PHARM BIOL}, journal = {PHARMACEUTICAL BIOLOGY}, volume = {60}, unique-id = {33049439}, issn = {1388-0209}, abstract = {Ambrosia artemisiifolia L. (Asteraceae) contains sesquiterpene lactones as characteristic secondary metabolites. Many of these compounds exert antiproliferative and cytotoxic effects.To isolate the sesquiterpene lactones from the aerial part of A. artemisiifolia and to elucidate their cytotoxic, antiproliferative and antibacterial effects.The compounds were identified by one-dimensional (1D) and 2D NMR, HR-MS spectroscopy from the methanol extract. Isolated compounds were investigated for their cytotoxic and antiproliferative effects on human colonic adenocarcinoma cell lines and human embryonal lung fibroblast cell line using MTT assay. The selectivity of the sesquiterpenes was calculated towards the normal cell line. To check the effect of drug interactions between compounds and doxorubicin, multidrug-resistant Colo 320 cells were used.A new seco-psilostachyinolide derivative, 1,10-dihydro-1'-noraltamisin, and seven known compounds were isolated from the methanol extract. Acetoxydihydrodamsin had the most potent cytotoxic effect on sensitive (Colo205) cell line (IC50 = 7.64 µM), also the strongest antiproliferative effect on Colo205 (IC50 = 5.14 µM) and Colo320 (IC50 = 3.67 µM) cell lines. 1'-Noraltamisin (IC50 = 8.78 µM) and psilostachyin (IC50 = 5.29 µM) showed significant antiproliferative effects on the multidrug-resistant Colo320 cell line and had moderate selectivity against human embryonal lung fibroblast cell line. Psilostachyin C exhibited cytotoxic effects on Colo205 cells (IC50 = 26.60 µM). None of the isolated compounds inhibited ABCB1 efflux pump (EP; P-glycoprotein) or the bacterial EPs.Acetoxydihydrodamsin, 1'-noraltamisin, and psilostachyin showed the most remarkable cytotoxic and antiproliferative activity on tumour cell lines and exerted selectivity towards MRC-5 cell line.}, keywords = {ASTERACEAE; RAGWEED; 1,10-dihydro-1′-noraltamisin; human colonic}, year = {2022}, eissn = {1744-5116}, pages = {1511-1519}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Kiss, Tivadar/0000-0003-3538-377X; Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:32554878, title = {Discovery of a novel class of small-molecule antibacterial agents against Staphylococcus aureus}, url = {https://m2.mtmt.hu/api/publication/32554878}, author = {Kreutzer, David and Gehrmann, Robin and Kincses, Annamária and Szemerédi, Nikoletta and Spengler, Gabriella and Molnár, József and Hilgeroth, Andreas}, doi = {10.4155/fmc-2021-0272}, journal-iso = {FUTURE MED CHEM}, journal = {FUTURE MEDICINAL CHEMISTRY}, volume = {14}, unique-id = {32554878}, issn = {1756-8919}, year = {2022}, eissn = {1756-8927}, pages = {299-305}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31605492, title = {Synthesis, characterization, thermal properties and biological activity of diazine-ring containing hydrazones and their metal complexes}, url = {https://m2.mtmt.hu/api/publication/31605492}, author = {Magyari, Józef and Barta Holló, Berta and Rodić, Marko V. and Jovanović, Ljiljana S. and Mészáros Szécsényi, Katalin and Ferenc, Wiesława and Osypiuk, Dariusz and Mosolygó, Tímea and Kincses, Annamária and Spengler, Gabriella}, doi = {10.1007/s10973-020-10194-z}, journal-iso = {J THERM ANAL CALORIM}, journal = {JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY}, volume = {147}, unique-id = {31605492}, issn = {1388-6150}, year = {2022}, eissn = {1572-8943}, pages = {229-242}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:33727591, title = {Xanthene Derivatives Targeting Bacterial Efflux Pumps, Quorum-Sensing, and Biofilm Formation}, url = {https://m2.mtmt.hu/api/publication/33727591}, author = {Maia, Miguel and Durães, Fernando and Resende, Diana I. S. P. and Szemerédi, Nikoletta and Gales, Luís and Martins-da-Costa, Paulo and Pinto, Madalena and Spengler, Gabriella and Sousa, Emília}, doi = {10.3390/ddc1010004}, journal-iso = {DRUGS DRUG CANDIDATES}, journal = {DRUGS AND DRUG CANDIDATES}, volume = {1}, unique-id = {33727591}, abstract = {The rise of multidrug resistance (MDR) bacteria in nosocomial and health-care institutions is widespread and is currently recognized as a major medical challenge. Mechanisms of bacterial resistance, namely, quorum sensing (QS), biofilm formation, and efflux pumps, have been identified as critical biological processes in MDR bacteria. Following previous reports on the activity of phenothiazines against mechanisms of bacterial resistance, in this work we focus on the synthesis of xanthene derivatives aiming to discover phenothiazine bioisosteres with improved activity. Four compounds were obtained from the conjugation of xanthydrol with sulfonamides and aniline and were fully characterized. Their antibacterial activity was assessed considering their minimum inhibitory concentration (MIC) against Gram-positive and Gram-negative strains, efflux pump inhibition, influence on biofilm formation and quorum-sensing (QS) inhibition. It was observed that the MIC of all the tested compounds was above 64 µg/mL The four 9-xanthenyl derivatives obtained, particularly the xanthene sulfonamide derivatives 3b and 3c, showed promising results on QS inhibition with a reduction of pigment production of 48 and 41 mm, and on biofilm formation with a reduction of 78 and 79%, respectively.}, year = {2022}, eissn = {2813-2998}, pages = {29-42}, orcid-numbers = {Durães, Fernando/0000-0003-4201-2774; Resende, Diana I. S. P./0000-0002-4077-6060; Gales, Luís/0000-0002-8352-6539; Martins-da-Costa, Paulo/0000-0001-6115-8811; Pinto, Madalena/0000-0002-4676-1409; Spengler, Gabriella/0000-0001-8085-0950; Sousa, Emília/0000-0002-5397-4672} } @article{MTMT:32682935, title = {Pharmaceutical and Safety Profile Evaluation of Novel Selenocompounds with Noteworthy Anticancer Activity}, url = {https://m2.mtmt.hu/api/publication/32682935}, author = {Marć, Małgorzata Anna and Domínguez-Álvarez, Enrique and Latacz, Gniewomir and Doroz-Płonka, Agata and Sanmartín, Carmen and Spengler, Gabriella and Handzlik, Jadwiga}, doi = {10.3390/pharmaceutics14020367}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32682935}, issn = {1999-4923}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Marć, Małgorzata Anna/0000-0002-5183-801X; Domínguez-Álvarez, Enrique/0000-0003-2655-1575; Latacz, Gniewomir/0000-0001-9247-2598; Sanmartín, Carmen/0000-0003-3431-7826; Spengler, Gabriella/0000-0001-8085-0950; Handzlik, Jadwiga/0000-0002-3674-3581} } @article{MTMT:32845488, title = {New diarylpentanoids and chalcones as potential antimicrobial adjuvants}, url = {https://m2.mtmt.hu/api/publication/32845488}, author = {Moreira, Joana and Durães, Fernando and Freitas-Silva, Joana and Szemerédi, Nikoletta and Resende, Diana I.S.P. and Pinto, Eugenia and da Costa, Paulo Martins and Pinto, Madalena and Spengler, Gabriella and Cidade, Honorina and Sousa, Emília}, doi = {10.1016/j.bmcl.2022.128743}, journal-iso = {BIOORG MED CHEM LETT}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, volume = {67}, unique-id = {32845488}, issn = {0960-894X}, year = {2022}, eissn = {1464-3405}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32609648, title = {A Practical Approach for Quantitative Polymerase Chain Reaction, the Gold Standard in Microbiological Diagnosis}, url = {https://m2.mtmt.hu/api/publication/32609648}, author = {Mosolygó, Tímea and Laczi, Krisztián and Spengler, Gabriella and Burián, Katalin}, doi = {10.3390/sci4010004}, journal-iso = {SCI}, journal = {SCI}, volume = {4}, unique-id = {32609648}, year = {2022}, eissn = {2413-4155}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Laczi, Krisztián/0000-0002-9399-7406; Spengler, Gabriella/0000-0001-8085-0950; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:33288701, title = {Derivatives of Trimethoxybenzoic Acid and Gallic Acid as Potential Efflux Pump Inhibitors: In Silico and In Vitro Studies}, url = {https://m2.mtmt.hu/api/publication/33288701}, author = {Neves, Ana Rita and Durães, Fernando and Freitas-Silva, Joana and Szemerédi, Nikoletta and Martins-da-Costa, Paulo and Pinto, Eugénia and Correia-da-Silva, Marta and Spengler, Gabriella and Sousa, Emília}, doi = {10.3390/ijms232214468}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {33288701}, issn = {1661-6596}, abstract = {The overexpression of efflux pumps is one of the strategies used by bacteria to resist antibiotics and could be targeted to circumvent the antibiotic crisis. In this work, a series of trimethoxybenzoic acid derivatives previously described as antifouling compounds was explored for potential antimicrobial activity and efflux pump (EP) inhibition. First, docking studies on the acridine resistance proteins A and B coupled to the outer membrane channel TolC (AcrAB-TolC) efflux system and a homology model of the quinolone resistance protein NorA EP were performed on 11 potential bioactive trimethoxybenzoic acid and gallic acid derivatives. The synthesis of one new trimethoxybenzoic acid derivative (derivative 13) was accomplished. To investigate the potential of this series of 11 derivatives as antimicrobial agents, and in reverting drug resistance, the minimum inhibitory concentration was determined on several strains (bacteria and fungi), and synergy with antibiotics and EP inhibition were investigated. Derivative 10 showed antibacterial activity against the studied strains, derivatives 5 and 6 showed the ability to inhibit EPs in the acrA gene inactivated mutant Salmonella enterica serovar Typhimurium SL1344, and 6 also inhibited EPs in Staphylococcus aureus 272123. Structure-activity relationships highlighted trimethoxybenzoic acid as important for EP inhibitory activity. Although further studies are necessary, these results show the potential of simple trimethoxybenzoic acid derivatives as a source of feasible EP inhibitors.}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Neves, Ana Rita/0000-0002-2766-8436; Durães, Fernando/0000-0003-4201-2774; Martins-da-Costa, Paulo/0000-0001-6115-8811; Pinto, Eugénia/0000-0003-2948-5809; Correia-da-Silva, Marta/0000-0003-4150-8532; Spengler, Gabriella/0000-0001-8085-0950; Sousa, Emília/0000-0002-5397-4672} } @article{MTMT:33288735, title = {New Chalcone–Triazole Hybrids with Promising Antimicrobial Activity in Multidrug Resistance Strains}, url = {https://m2.mtmt.hu/api/publication/33288735}, author = {Pereira, Daniela and Durães, Fernando and Szemerédi, Nikoletta and Freitas-da-Silva, Joana and Pinto, Eugénia and Martins-da-Costa, Paulo and Pinto, Madalena and Correia-da-Silva, Marta and Spengler, Gabriella and Sousa, Emília and Cidade, Honorina}, doi = {10.3390/ijms232214291}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {33288735}, issn = {1661-6596}, abstract = {Resistance to antibiotics is an emerging problem worldwide, which leads to an increase in morbidity and mortality rates. Several mechanisms are attributed to bacterial resistance, overexpression of efflux pumps being one of the most prominent. As an attempt to develop new effective antimicrobial drugs, which could be able to act against resistant bacterial strains and considering the antimicrobial potential of flavonoids and triazolyl flavonoid derivatives, in particular chalcones, a small library of chalcone derivatives was synthesized and evaluated for its potential to act as antimicrobials and/or adjuvants in combination with antibiotics towards resistant bacteria. Although only compound 7 was able to act as antibacterial, compounds 1, 2, 4, 5, 7, and 9 revealed to be able to potentiate the activity of antibiotics in resistant bacteria. Moreover, five compounds (3, 5–8) demonstrated to be effective inhibitors of efflux pumps in Salmonella enterica serovar Typhimurium SL1344, and four compounds (1, 3, 7, and 10) showed higher ability than reserpine to inhibit biofilm formation of resistant Staphylococcus aureus 272123. Together, our results showed the potential of these compounds regarding reversion of bacterial resistance.}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Pereira, Daniela/0000-0002-5711-7598; Durães, Fernando/0000-0003-4201-2774; Pinto, Eugénia/0000-0003-2948-5809; Martins-da-Costa, Paulo/0000-0001-6115-8811; Pinto, Madalena/0000-0002-4676-1409; Correia-da-Silva, Marta/0000-0003-4150-8532; Spengler, Gabriella/0000-0001-8085-0950; Sousa, Emília/0000-0002-5397-4672; Cidade, Honorina/0000-0003-0715-1779} } @article{MTMT:32747057, title = {A comparative study on the complex formation of 2-aminoestradiol and 2-aminophenol with divalent metal ions: solution chemistry and anticancer activity}, url = {https://m2.mtmt.hu/api/publication/32747057}, author = {Petrasheuskaya, Tatsiana and Kovács, Ferenc and Spengler, Gabriella and May, Nóra Veronika and Nagyné Frank, Éva and Enyedy, Éva Anna}, doi = {10.1016/j.molstruc.2022.132858}, journal-iso = {J MOL STRUCT}, journal = {JOURNAL OF MOLECULAR STRUCTURE}, volume = {1261}, unique-id = {32747057}, issn = {0022-2860}, year = {2022}, eissn = {1872-8014}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; May, Nóra Veronika/0000-0003-4770-4681; Nagyné Frank, Éva/0000-0002-1332-0551; Enyedy, Éva Anna/0000-0002-8058-8128} } @CONFERENCE{MTMT:33661605, title = {Investigation of the interaction of a water-soluble 8-hydroxyquinoline amino acid hybrid with essential metal ions}, url = {https://m2.mtmt.hu/api/publication/33661605}, author = {Pósa, Vivien and May, V. Nóra and Spengler, Gabriella and Pósa, Szonja and Tóth, Szilárd and Szakács, Gergely and Ugrai, Imre and Szatmári, István and Nagy, Petra and Enyedy, Éva Anna}, booktitle = {Acta of the International Symposia on Thermodynamics of Metal Complexes}, unique-id = {33661605}, year = {2022}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Szatmári, István/0000-0002-8571-5229} } @article{MTMT:32729344, title = {The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity}, url = {https://m2.mtmt.hu/api/publication/32729344}, author = {Pósa, Vivien and Hajdu, Bálint and Tóth, Gábor and Dömötör, Orsolya and Kowol, Christian R. and Keppler, Bernhard K. and Spengler, Gabriella and Gyurcsik, Béla and Enyedy, Éva Anna}, doi = {10.1016/j.jinorgbio.2022.111786}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {231}, unique-id = {32729344}, issn = {0162-0134}, year = {2022}, eissn = {1873-3344}, orcid-numbers = {Dömötör, Orsolya/0000-0001-8736-3215; Spengler, Gabriella/0000-0001-8085-0950; Gyurcsik, Béla/0000-0003-1894-7414; Enyedy, Éva Anna/0000-0002-8058-8128} } @misc{MTMT:32845756, title = {Targeting bacteria and their virulence with phenothiazine-type antipsychotics}, url = {https://m2.mtmt.hu/api/publication/32845756}, author = {Rácz, Bálint and Kincses, Annamária and Szemerédi, Nikoletta and Bo Young, Huh and Borbély, Bence and Mosolygó, Tímea and Spengler, Gabriella}, unique-id = {32845756}, year = {2022}, orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:33049861, title = {Ingol, ent-atisane, and stachane-type diterpenoids from Euphorbia deightonii with multidrug resistance reversing activity}, url = {https://m2.mtmt.hu/api/publication/33049861}, author = {Saidu, Muhammad Bello and Kúsz, Norbert and Berkecz, Róbert and Rácz, Bálint and Spengler, Gabriella and Hohmann, Judit and Rédei, Dóra}, doi = {10.1016/j.phytochem.2022.113344}, journal-iso = {PHYTOCHEMISTRY}, journal = {PHYTOCHEMISTRY}, volume = {204}, unique-id = {33049861}, issn = {0031-9422}, abstract = {Nine previously undescribed ingol-type diterpenoid polyesters with eighteen known ingol esters, two ent-atisane, and one stachane diterpenoid were isolated from the methanol extract of Euphorbia deightonii Croizat. The structures were established by extensive spectroscopic analysis involving 1D (1H, 13C J-modulation) and 2D NMR experiments, HRESIMS measurements, and the comparison of the spectroscopic data with reported literature values. The cytotoxic concentrations of 13 isolated compounds were determined, and the compounds were investigated for multidrug resistance modulating activity on an L5178 mouse lymphoma cell line using a rho-damin 123 accumulation assay. Six ingol esters demonstrated the significant inhibition of P-glycoprotein, while the two ent-atisane diterpenoids were found to be inactive. The measured activities allowed to establish some structure-activity relationships. Notably, lower and higher-type diterpenoids simultaneously occurred in E. deightonii.}, year = {2022}, eissn = {1873-3700}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Berkecz, Róbert/0000-0002-9076-2177; Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392; Rédei, Dóra/0000-0002-5013-247X} } @article{MTMT:33077788, title = {Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells}, url = {https://m2.mtmt.hu/api/publication/33077788}, author = {Silva, Cristina Duarte and Ramalhete, Cátia and Spengler, Gabriella and Mulhovo, Silva and Molnár, József and Ferreira, Maria-José U.}, doi = {10.1016/j.phytochem.2022.113354}, journal-iso = {PHYTOCHEMISTRY}, journal = {PHYTOCHEMISTRY}, volume = {203}, unique-id = {33077788}, issn = {0031-9422}, year = {2022}, eissn = {1873-3700}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32768189, title = {Evaluation of the Antimicrobial and Antivirulent Potential of Essential Oils Isolated from Juniperus oxycedrus L. ssp. macrocarpa Aerial Parts}, url = {https://m2.mtmt.hu/api/publication/32768189}, author = {Spengler, Gabriella and Gajdács, Márió and Donadu, Matthew Gavino and Usai, Marianna and Marchetti, Mauro and Ferrari, Marco and Mazzarello, Vittorio and Zanetti, Stefania and Nagy, Fruzsina and Kovács, Renátó}, doi = {10.3390/microorganisms10040758}, journal-iso = {MICROORGANISMS}, journal = {MICROORGANISMS}, volume = {10}, unique-id = {32768189}, issn = {2076-2607}, abstract = {As a consequence of the worsening situation with multidrug-resistant (MDR) pathogens and a disparity in the commercialization of novel antimicrobial agents, scientists have been prompted to seek out new compounds with antimicrobial activity from a wide range of sources, including medicinal plants. In the present study, the antibacterial, antifungal, anti-virulence, and resistance-modulating properties of the essential oil from the Sardinian endemic Juniperus oxycedrus L. ssp. macrocarpa aerial parts were evaluated. The GC/MS analysis showed that the main compounds in the oil were alpha-pinene (56.63 +/- 0.24%), limonene (14.66 +/- 0.11%), and beta-pinene (13.42 +/- 0.09%). The essential oil showed potent antibacterial activity against Gram-positive bacteria (0.25-2 v/v%) and Salmonella spp. (4 v/v%). The strongest fungicidal activity was recorded against Candida auris sessile cells (median FICI was 0.088) but not against C. albicans biofilms (median FICI was 1). The oil showed potent efflux pump inhibitory properties in the case of Staphylococcus aureus and Escherichia coli. The therapeutic potential of Juniperus may be promising for future more extensive research and in vivo tests to develop new drugs against antibiotic and antifungal resistance.}, keywords = {IN-VITRO; SUSCEPTIBILITY; ANTIBACTERIAL; multidrug resistance; ANTIFUNGAL; CONSTITUENTS; extracts; antibacterial activity; Biofilm; Candida; Essential oil; efflux pump; ANTIBIOTIC-RESISTANCE; combinations; C; Juniperus oxycedrus; CANDIDA-AURIS; auris}, year = {2022}, eissn = {2076-2607}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Gajdács, Márió/0000-0003-1270-0365; Donadu, Matthew Gavino/0000-0001-7681-6194; Ferrari, Marco/0000-0001-7331-0032; Kovács, Renátó/0000-0003-3946-2424} } @article{MTMT:32793306, title = {Unique Phenanthrenes from Juncus ensifolius and Their Antiproliferative and Synergistic Effects with the Conventional Anticancer Agent Doxorubicin against Human Cancer Cell Lines}, url = {https://m2.mtmt.hu/api/publication/32793306}, author = {Stefkó, Dóra and Kúsz, Norbert and Szemerédi, Nikoletta and Barta, Anita and Spengler, Gabriella and Berkecz, Róbert and Hohmann, Judit and Vasas, Andrea}, doi = {10.3390/pharmaceutics14030608}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32793306}, issn = {1999-4923}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X; Kúsz, Norbert/0000-0002-9973-6442; Spengler, Gabriella/0000-0001-8085-0950; Berkecz, Róbert/0000-0002-9076-2177; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} } @article{MTMT:32770194, title = {Diversity-Oriented Synthesis Catalyzed by Diethylaminosulfur-Trifluoride—Preparation of New Antitumor Ecdysteroid Derivatives}, url = {https://m2.mtmt.hu/api/publication/32770194}, author = {Vágvölgyi, Máté and Kocsis, Endre and Nové, Márta and Szemerédi, Nikoletta and Spengler, Gabriella and Kele, Zoltán and Berkecz, Róbert and Gáti, Tamás and Tóth, Gábor and Hunyadi, Attila}, doi = {10.3390/ijms23073447}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {32770194}, issn = {1661-6596}, abstract = {Fluorine represents a privileged building block in pharmaceutical chemistry. Diethylaminosulfur-trifluoride (DAST) is a reagent commonly used for replacement of alcoholic hydroxyl groups with fluorine and is also known to catalyze water elimination and cyclic Beckmann-rearrangement type reactions. In this work we aimed to use DAST for diversity-oriented semisynthetic transformation of natural products bearing multiple hydroxyl groups to prepare new bioactive compounds. Four ecdysteroids, including a new constituent of Cyanotis arachnoidea, were selected as starting materials for DAST-catalyzed transformations. The newly prepared compounds represented combinations of various structural changes DAST was known to catalyze, and a unique cyclopropane ring closure that was found for the first time. Several compounds demonstrated in vitro antitumor properties. A new 17-N-acetylecdysteroid (13) exerted potent antiproliferative activity and no cytotoxicity on drug susceptible and multi-drug resistant mouse T-cell lymphoma cells. Further, compound 13 acted in significant synergism with doxorubicin without detectable direct ABCB1 inhibition. Our results demonstrate that DAST is a versatile tool for diversity-oriented synthesis to expand chemical space towards new bioactive compounds.}, keywords = {NMR; FLUORINATION; structure elucidation; natural product; ecdysteroid; Anticancer}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Spengler, Gabriella/0000-0001-8085-0950; Kele, Zoltán/0000-0002-4401-0302; Berkecz, Róbert/0000-0002-9076-2177; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:32851553, title = {The Release of a Highly Cytotoxic Paullone Bearing a TEMPO Free Radical from the HSA Hydrogel: An EPR Spectroscopic Characterization}, url = {https://m2.mtmt.hu/api/publication/32851553}, author = {Vesković, Ana and Nakarada, Đura and Vasiljević, Olga and Dobrov, Anatolie and Spengler, Gabriella and Enyedy, Éva Anna and Arion, Vladimir B. and Popović Bijelić, Ana}, doi = {10.3390/pharmaceutics14061174}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32851553}, issn = {1999-4923}, year = {2022}, eissn = {1999-4923}, pages = {1174-1193}, orcid-numbers = {Vesković, Ana/0000-0002-2070-6305; Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128; Arion, Vladimir B./0000-0002-1895-6460; Popović Bijelić, Ana/0000-0003-3121-2391} } @article{MTMT:32639268, title = {Highly Antiproliferative Latonduine and Indolo[2,3- c ]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile}, url = {https://m2.mtmt.hu/api/publication/32639268}, author = {Wittmann, Christopher and Bacher, Felix and Enyedy, Éva Anna and Dömötör, Orsolya and Spengler, Gabriella and Madejski, Christian and Reynisson, Jóhannes and Arion, Vladimir B.}, doi = {10.1021/acs.jmedchem.1c01740}, journal-iso = {J MED CHEM}, journal = {JOURNAL OF MEDICINAL CHEMISTRY}, volume = {65}, unique-id = {32639268}, issn = {0022-2623}, year = {2022}, eissn = {1520-4804}, pages = {2238-2261}, orcid-numbers = {Enyedy, Éva Anna/0000-0002-8058-8128; Dömötör, Orsolya/0000-0001-8736-3215; Spengler, Gabriella/0000-0001-8085-0950; Reynisson, Jóhannes/0000-0003-4174-9512; Arion, Vladimir B./0000-0002-1895-6460} } @article{MTMT:32746758, title = {Triterpenes from Pholiota populnea as Cytotoxic Agents and Chemosensitizers to Overcome Multidrug Resistance of Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/32746758}, author = {Yazdani, Morteza and Béni, Zoltán and Dékány, Miklós and Szemerédi, Nikoletta and Spengler, Gabriella and Hohmann, Judit and Ványolós, Attila}, doi = {10.1021/acs.jnatprod.1c01024}, journal-iso = {J NAT PROD}, journal = {JOURNAL OF NATURAL PRODUCTS}, volume = {85}, unique-id = {32746758}, issn = {0163-3864}, year = {2022}, eissn = {1520-6025}, pages = {910-916}, orcid-numbers = {Béni, Zoltán/0000-0002-1275-4155; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392; Ványolós, Attila/0000-0002-4710-0004} } @article{MTMT:33179818, title = {5-Arylidenerhodanines as P-gp Modulators: An Interesting Effect of the Carboxyl Group on ABCB1 Function in Multidrug-Resistant Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/33179818}, author = {Zeslawska, Ewa and Tejchman, Waldemar and Kincses, Annamária and Spengler, Gabriella and Nitek, Wojciech and Zuchowski, Grzegorz and Szymanska, Ewa}, doi = {10.3390/ijms231810812}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {33179818}, issn = {1661-6596}, abstract = {Multidrug resistance (MDR) is considered one of the major mechanisms responsible for the failure of numerous anticancer and antiviral chemotherapies. Various strategies to overcome the MDR phenomenon have been developed, and one of the most attractive research directions is focused on the inhibition of MDR transporters, membrane proteins that extrude cytotoxic drugs from living cells. Here, we report the results of our studies on a series newly synthesized of 5-arylidenerhodanines and their ability to inhibit the ABCB1 efflux pump in mouse T-lymphoma cancer cells. In the series, compounds possessing a triphenylamine moiety and the carboxyl group in their structure were of particular interest. These amphiphilic compounds showed over 17-fold stronger efflux pump inhibitory effects than verapamil. The cytotoxic and antiproliferative effects of target rhodanines on T-lymphoma cells were also investigated. A putative binding mode for 11, one of the most potent P-gp inhibitors tested here, was predicted by molecular docking studies and discussed with regard to the binding mode of verapamil.}, keywords = {P-GLYCOPROTEIN; crystal structure; Molecular docking; Efflux pump inhibition; Cancer multidrug resistance; rhodanine; T-lymphoma cancer cells}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32471515, title = {Symmetric Selenoesters as Potent Efflux Pump Inhibitors in Colon Adenocarcinoma Cells}, url = {https://m2.mtmt.hu/api/publication/32471515}, author = {Rácz, Bálint and Kincses, Annamária and Miguel, Benito-Lama and Ana, Gonzalez-Prádena and Enrique, Dominguez-Álvarez and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {68}, unique-id = {32471515}, issn = {1217-8950}, year = {2021}, eissn = {1588-2640}, pages = {34-34}, orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31930155, title = {Triterpenes and Phenolic Compounds from the Fungus Fuscoporia torulosa: Isolation, Structure Determination and Biological Activity}, url = {https://m2.mtmt.hu/api/publication/31930155}, author = {Béni, Zoltán and Dékány, Miklós and Sárközy, András and Kincses, Annamária and Spengler, Gabriella and Papp, Viktor and Hohmann, Judit and Ványolós, Attila}, doi = {10.3390/molecules26061657}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {26}, unique-id = {31930155}, issn = {1420-3049}, year = {2021}, eissn = {1420-3049}, orcid-numbers = {Béni, Zoltán/0000-0002-1275-4155; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392; Ványolós, Attila/0000-0002-4710-0004} } @article{MTMT:32112075, title = {Triapine Analogues and Their Copper(II) Complexes: Synthesis, Characterization, Solution Speciation, Redox Activity, Cytotoxicity, and mR2 RNR Inhibition}, url = {https://m2.mtmt.hu/api/publication/32112075}, author = {Besleaga, Iuliana and Stepanenko, Iryna and Petrasheuskaya, Tatsiana and Darvasiova, Denisa and Breza, Martin and Hammerstad, Marta and Marć, Małgorzata A. and Prado-Roller, Alexander and Spengler, Gabriella and Popović-Bijelić, Ana and Enyedy, Éva Anna and Rapta, Peter and Shutalev, Anatoly D. and Arion, Vladimir B.}, doi = {10.1021/acs.inorgchem.1c01275}, journal-iso = {INORG CHEM}, journal = {INORGANIC CHEMISTRY}, volume = {60}, unique-id = {32112075}, issn = {0020-1669}, year = {2021}, eissn = {1520-510X}, pages = {11297-11319}, orcid-numbers = {Breza, Martin/0000-0001-5995-0279; Spengler, Gabriella/0000-0001-8085-0950; Popović-Bijelić, Ana/0000-0003-3121-2391; Enyedy, Éva Anna/0000-0002-8058-8128; Shutalev, Anatoly D./0000-0002-8038-8230; Arion, Vladimir B./0000-0002-1895-6460} } @article{MTMT:32287706, title = {Exploring the Monoterpene Indole Alkaloid Scaffold for Reversing P-Glycoprotein-Mediated Multidrug Resistance in Cancer}, url = {https://m2.mtmt.hu/api/publication/32287706}, author = {Cardoso, David and Szemerédi, Nikoletta and Spengler, Gabriella and Mulhovo, Silva and dos Santos, Daniel and Ferreira, Maria-José}, doi = {10.3390/ph14090862}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {14}, unique-id = {32287706}, abstract = {Dregamine (1), a major monoterpene indole alkaloid isolated from Tabernaemontana elegans, was submitted to chemical transformation of the ketone function, yielding 19 azines (3-21) and 11 semicarbazones (22-32) bearing aliphatic or aromatic substituents. Their structures were assigned mainly by 1D and 2D NMR (COSY, HMQC, and HMBC) experiments. Compounds 3-32 were evaluated as multidrug resistance (MDR) reversers through functional and chemosensitivity assays in a human ABCB1-transfected mouse T-lymphoma cell model, overexpressing P-glycoprotein. A significant increase of P-gp inhibitory activity was observed for most derivatives, mainly those containing azine moieties with aromatic substituents. Compounds with trimethoxyphenyl (17) or naphthyl motifs (18, 19) were among the most active, exhibiting strong inhibition at 0.2 mu M. Moreover, most of the derivatives showed selective antiproliferative effects toward resistant cells, having a collateral sensitivity effect. In drug combination assays, all compounds showed to interact synergistically with doxorubicin. Selected compounds (12, 17, 18, 20, and 29) were evaluated in the ATPase activity assay, in which all compounds but 12 behaved as inhibitors. To gather further insights on drug-receptor interactions, in silico studies were also addressed. A QSAR model allowed us to deduce that compounds bearing bulky and lipophilic substituents were stronger P-gp inhibitors.}, keywords = {multidrug resistance; INDOLE ALKALOIDS; Molecular docking; ATPASE ACTIVITY; Tabernaemontana elegans; QSAR MODELS}, year = {2021}, eissn = {1424-8247}, orcid-numbers = {Cardoso, David/0000-0002-8270-4276; Spengler, Gabriella/0000-0001-8085-0950; Ferreira, Maria-José/0000-0002-8742-1486} } @article{MTMT:31656647, title = {Alkylated monoterpene indole alkaloid derivatives as potent P-glycoprotein inhibitors in resistant cancer cells}, url = {https://m2.mtmt.hu/api/publication/31656647}, author = {Cardoso, David S.P. and Kincses, Annamária and Nové, Márta and Spengler, Gabriella and Mulhovo, Silva and Aires-de-Sousa, João and dos Santos, Daniel J.V. A. and Ferreira, Maria-José U.}, doi = {10.1016/j.ejmech.2020.112985}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {210}, unique-id = {31656647}, issn = {0223-5234}, year = {2021}, eissn = {1768-3254}, orcid-numbers = {Cardoso, David S.P./0000-0002-8270-4276; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32491607, title = {Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria}, url = {https://m2.mtmt.hu/api/publication/32491607}, author = {Durães, Fernando and Cravo, Sara and Freitas-Silva, Joana and Szemerédi, Nikoletta and Martins-da-Costa, Paulo and Pinto, Eugénia and Tiritan, Maria Elizabeth and Spengler, Gabriella and Fernandes, Carla and Sousa, Emília and Pinto, Madalena}, doi = {10.3390/ph14111141}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {14}, unique-id = {32491607}, year = {2021}, eissn = {1424-8247}, orcid-numbers = {Cravo, Sara/0000-0001-9314-8669; Martins-da-Costa, Paulo/0000-0001-6115-8811; Pinto, Eugénia/0000-0003-2948-5809; Tiritan, Maria Elizabeth/0000-0003-3320-730X; Spengler, Gabriella/0000-0001-8085-0950; Fernandes, Carla/0000-0003-0940-9163; Sousa, Emília/0000-0002-5397-4672; Pinto, Madalena/0000-0002-4676-1409} } @article{MTMT:32157094, title = {Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants}, url = {https://m2.mtmt.hu/api/publication/32157094}, author = {Durães, Fernando and Szemerédi, Nikoletta and Kumla, Decha and Pinto, Madalena and Kijjoa, Anake and Spengler, Gabriella and Sousa, Emília}, doi = {10.3390/md19090475}, journal-iso = {MAR DRUGS}, journal = {MARINE DRUGS}, volume = {19}, unique-id = {32157094}, issn = {1660-3397}, year = {2021}, eissn = {1660-3397}, orcid-numbers = {Kumla, Decha/0000-0002-1434-3958; Pinto, Madalena/0000-0002-4676-1409; Kijjoa, Anake/0000-0002-3321-1061; Spengler, Gabriella/0000-0001-8085-0950; Sousa, Emília/0000-0002-5397-4672} } @article{MTMT:32025517, title = {Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria}, url = {https://m2.mtmt.hu/api/publication/32025517}, author = {Durães, Fernando and Resende, Diana I. S. P. and Palmeira, Andreia and Szemerédi, Nikoletta and Pinto, Madalena M. M. and Spengler, Gabriella and Sousa, Emília}, doi = {10.3390/antibiotics10050600}, journal-iso = {ANTIBIOTICS-BASEL}, journal = {ANTIBIOTICS}, volume = {10}, unique-id = {32025517}, year = {2021}, eissn = {2079-6382}, orcid-numbers = {Durães, Fernando/0000-0003-4201-2774; Resende, Diana I. S. P./0000-0002-4077-6060; Palmeira, Andreia/0000-0002-1391-2143; Szemerédi, Nikoletta/0000-0002-8638-5815; Pinto, Madalena M. M./0000-0002-4676-1409; Spengler, Gabriella/0000-0001-8085-0950; Sousa, Emília/0000-0002-5397-4672} } @article{MTMT:31989135, title = {Complex formation of an estrone-salicylaldehyde semicarbazone hybrid with copper(II) and gallium(III): Solution equilibria and biological activity}, url = {https://m2.mtmt.hu/api/publication/31989135}, author = {Enyedy, Éva Anna and Petrasheuskaya, Tatsiana and Kiss, Márton Attila and Wernitznig, Debora and Wenisch, Dominik and Keppler, Bernhard K. and Spengler, Gabriella and May, Nóra Veronika and Nagyné Frank, Éva and Dömötör, Orsolya}, doi = {10.1016/j.jinorgbio.2021.111468}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {220}, unique-id = {31989135}, issn = {0162-0134}, year = {2021}, eissn = {1873-3344}, orcid-numbers = {Enyedy, Éva Anna/0000-0002-8058-8128; Spengler, Gabriella/0000-0001-8085-0950; May, Nóra Veronika/0000-0003-4770-4681; Nagyné Frank, Éva/0000-0002-1332-0551; Dömötör, Orsolya/0000-0001-8736-3215} } @article{MTMT:32072454, title = {Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors}, url = {https://m2.mtmt.hu/api/publication/32072454}, author = {Fernando, Durães and Andreia, Palmeira and Bárbara, Cruz and Joana, Freitas-Silva and Szemerédi, Nikoletta and Luís, Gales and Paulo, Martins da Costa and Fernando, Remião and Renata, Silva and Madalena, Pinto and Spengler, Gabriella and Emília, Sousa}, doi = {10.3390/ph14060572}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {32072454}, issn = {1999-4923}, year = {2021}, eissn = {1999-4923}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31790652, title = {Pedrolane, a Polycyclic Diterpene Scaffold Containing a Bicyclo[2.2.1]heptane System, from Euphorbia pedroi}, url = {https://m2.mtmt.hu/api/publication/31790652}, author = {Ferreira, Ricardo J. and Spengler, Gabriella and Orthaber, Andreas and dos Santos, Daniel J. V. A. and Ferreira, Maria-José U.}, doi = {10.1021/acs.orglett.0c03647}, journal-iso = {ORG LETT}, journal = {ORGANIC LETTERS}, volume = {23}, unique-id = {31790652}, issn = {1523-7060}, year = {2021}, eissn = {1523-7052}, pages = {274-278}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32021264, title = {Computer‐aided search for 5‐arylideneimidazolone anticancer agents able to overcome ABCB1‐based multidrug resistance}, url = {https://m2.mtmt.hu/api/publication/32021264}, author = {Kaczor, Aneta and Szemerédi, Nikoletta and Kucwaj-Brysz, Katarzyna and Dąbrowska, Monika and Starek, Małgorzata and Latacz, Gniewomir and Spengler, Gabriella and Handzlik, Jadwiga}, doi = {10.1002/cmdc.202100252}, journal-iso = {CHEMMEDCHEM}, journal = {CHEMMEDCHEM}, volume = {16}, unique-id = {32021264}, issn = {1860-7179}, year = {2021}, eissn = {1860-7187}, pages = {2386-2401}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32507776, title = {The Relationship between Antibiotic Susceptibility and pH in the Case of Uropathogenic Bacteria}, url = {https://m2.mtmt.hu/api/publication/32507776}, author = {Kincses, Annamária and Rácz, Bálint and Baaity, Zain and Vásárhelyi, Orsolya and Kristóf, Erzsébet and Somogyvári, Ferenc and Spengler, Gabriella}, doi = {10.3390/antibiotics10121431}, journal-iso = {ANTIBIOTICS-BASEL}, journal = {ANTIBIOTICS}, volume = {10}, unique-id = {32507776}, year = {2021}, eissn = {2079-6382}, pages = {1431-1441}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Rácz, Bálint/0000-0003-0088-3408; Baaity, Zain/0000-0001-6411-382X; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31921807, title = {Juncaceae Species as Promising Sources of Phenanthrenes: Antiproliferative Compounds from Juncus maritimus Lam}, url = {https://m2.mtmt.hu/api/publication/31921807}, author = {Kúsz, Norbert and Stefkó, Dóra and Barta, Anita and Kincses, Annamária and Szemerédi, Nikoletta and Spengler, Gabriella and Hohmann, Judit and Vasas, Andrea}, doi = {10.3390/molecules26040999}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {26}, unique-id = {31921807}, issn = {1420-3049}, abstract = {Juncaceae family represents an abundant source of phenanthrenes. In continuation of our work aiming at the isolation of biologically active compounds from Juncaceae species, Juncus maritimus Lam. was subjected to phytochemical and pharmacological investigations. The isolation process was carried out by using combined extraction and chromatographic methods. The structures of the obtained chemical compounds were elucidated by spectroscopic analysis, including HRESIMS, 1D (H-1, C-13-JMOD), and 2D (H-1-H-1-COSY, HSQC, HMBC, NOESY) NMR spectra. Four new [maritins A-D (1-4)] and seven known phenanthrenes (5-11) were isolated from the plant, of which two (4 and 11) are phenanthrene dimers composed of effusol monomers. Maritin C (3) has an unusual 4,5-ethanophenanthrene skeleton most likely produced by biosynthetic incorporation of a vinyl group into a cyclohexadiene ring. Compounds 1-11 were tested for their antiproliferative activity on seven human tumor cell lines (HeLa, HTM-26, T-47D, A2780, A2780cis, MCF-7, KCR) and one normal cell line (MRC-5) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The dimeric phenanthrenes showed strong antiproliferative activity against T-47D cells with IC50 values of 9.1 and 6.2 mu M, respectively.}, keywords = {d; Biochemistry & Molecular Biology; Juncus maritimus; maritins A–; phenanthrene dimers}, year = {2021}, eissn = {1420-3049}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Stefkó, Dóra/0000-0002-5435-546X; Kincses, Annamária/0000-0002-1591-1419; Szemerédi, Nikoletta/0000-0002-8638-5815; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} } @article{MTMT:32471631, title = {Selenoesters as Efflux Pump Inhibitors in Bacteria and Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/32471631}, author = {Szemerédi, Nikoletta and Kincses, Annamária and Gábor, Tóth and Enrique, Domingez-Alvarez and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {68}, unique-id = {32471631}, issn = {1217-8950}, year = {2021}, eissn = {1588-2640}, pages = {116-116}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32471622, title = {Inhibition of Quorum Sensing by Conventional Antibiotics and Resistance Modifiers}, url = {https://m2.mtmt.hu/api/publication/32471622}, author = {Szemerédi, Nikoletta and Bo, Young Huh and Rácz, Bálint and Spengler, Gabriella and Kincses, Annamária}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {68}, unique-id = {32471622}, issn = {1217-8950}, year = {2021}, eissn = {1588-2640}, pages = {115-115}, orcid-numbers = {Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419} } @article{MTMT:32471526, title = {Selenoesters as Potential Quorum Sensing-Inhibiting and Anti-biofilm Compounds in Bacteria}, url = {https://m2.mtmt.hu/api/publication/32471526}, author = {Szemerédi, Nikoletta and Kincses, Annamária and Jitka, Viktorova and Enrique, Dominguez-Álvarez and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {68}, unique-id = {32471526}, issn = {1217-8950}, year = {2021}, eissn = {1588-2640}, pages = {40-40}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:32463170, title = {8-Hydroxyquinoline-Amino Acid Hybrids and Their Half-Sandwich Rh and Ru Complexes: Synthesis, Anticancer Activities, Solution Chemistry and Interaction with Biomolecules}, url = {https://m2.mtmt.hu/api/publication/32463170}, author = {Pivarcsik, Tamás and Dömötör, Orsolya and Mészáros, János Péter and May, Nóra Veronika and Spengler, Gabriella and Csuvik, Oszkár and Szatmári, István and Enyedy, Éva Anna}, doi = {10.3390/ijms222011281}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {32463170}, issn = {1661-6596}, year = {2021}, eissn = {1422-0067}, orcid-numbers = {Dömötör, Orsolya/0000-0001-8736-3215; Mészáros, János Péter/0000-0001-6301-5259; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Szatmári, István/0000-0002-8571-5229; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:32039543, title = {Comparison of Solution Chemical Properties and Biological Activity of Ruthenium Complexes of Selected β-Diketone, 8-Hydroxyquinoline and Pyrithione Ligands}, url = {https://m2.mtmt.hu/api/publication/32039543}, author = {Pivarcsik, Tamás and Tóth, Gábor and Szemerédi, Nikoletta and Bogdanov, Anita and Spengler, Gabriella and Kljun, Jakob and Kladnik, Jerneja and Turel, Iztok and Enyedy, Éva Anna}, doi = {10.3390/ph14060518}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {14}, unique-id = {32039543}, year = {2021}, eissn = {1424-8247}, orcid-numbers = {Bogdanov, Anita/0000-0003-3067-8835; Spengler, Gabriella/0000-0001-8085-0950; Kljun, Jakob/0000-0002-1986-4840; Turel, Iztok/0000-0001-6776-4062; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:31984388, title = {Increased antibacterial properties of indoline-derived phenolic Mannich bases}, url = {https://m2.mtmt.hu/api/publication/31984388}, author = {Rimpilauinen, Tatu and Nunes, Alexandra and Calado, Rita and Fernandes, Ana S. and Andrade, Joana and Ntungwe, Epole and Spengler, Gabriella and Szemerédi, Nikoletta and Rodrigues, Joao and Gomes, Joao Paulo and Rijo, Patricia and Candeias, Nuno R.}, doi = {10.1016/j.ejmech.2021.113459}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {220}, unique-id = {31984388}, issn = {0223-5234}, year = {2021}, eissn = {1768-3254}, orcid-numbers = {Nunes, Alexandra/0000-0001-6449-8053; Calado, Rita/0000-0002-2519-7917; Fernandes, Ana S./0000-0001-6350-0641; Andrade, Joana/0000-0002-2088-4451; Ntungwe, Epole/0000-0001-6596-8985; Spengler, Gabriella/0000-0001-8085-0950; Candeias, Nuno R./0000-0003-2414-9064} } @article{MTMT:31696470, title = {In vitro adjuvant antitumor activity of various classes of semi-synthetic poststerone derivatives}, url = {https://m2.mtmt.hu/api/publication/31696470}, author = {Savchenko, Rimma G. and Nové, Márta and Spengler, Gabriella and Hunyadi, Attila and Parfenova, Lyudmila V.}, doi = {10.1016/j.bioorg.2020.104485}, journal-iso = {BIOORG CHEM}, journal = {BIOORGANIC CHEMISTRY}, volume = {106}, unique-id = {31696470}, issn = {0045-2068}, year = {2021}, eissn = {1090-2120}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:33041581, title = {Biologically active phenanthrenes from four Juncus species native to Hungary}, url = {https://m2.mtmt.hu/api/publication/33041581}, author = {Stefkó, Dóra and Kúsz, Norbert and Szemerédi, Nikoletta and Spengler, Gabriella and Hohmann, Judit and Vasas, Andrea}, doi = {10.1055/s-0041-1736786}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {87}, unique-id = {33041581}, issn = {0032-0943}, year = {2021}, eissn = {1439-0221}, pages = {1251-1251}, orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X; Kúsz, Norbert/0000-0002-9973-6442; Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} } @article{MTMT:32096604, title = {Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity}, url = {https://m2.mtmt.hu/api/publication/32096604}, author = {Stepanenko, Iryna and Babak, Maria V. and Spengler, Gabriella and Hammerstad, Marta and Popovic-Bijelic, Ana and Shova, Sergiu and Buchel, Gabriel E. and Darvasiova, Denisa and Rapta, Peter and Arion, Vladimir B.}, doi = {10.3390/biom11060862}, journal-iso = {BIOMOLECULES}, journal = {BIOMOLECULES}, volume = {11}, unique-id = {32096604}, issn = {2218-273X}, abstract = {A series of thiosemicarbazone-coumarin hybrids (HL1-HL3 and H2L4) has been synthesised in 12 steps and used for the preparation of mono- and dinuclear copper(II) complexes, namely Cu(HL1)Cl-2 (1), Cu(HL2)Cl-2 (2), Cu(HL3)Cl-2 (3) and Cu-2(H2L4)Cl-4 (4), isolated in hydrated or solvated forms. Both the organic hybrids and their copper(II) and dicopper(II) complexes were comprehensively characterised by analytical and spectroscopic techniques, i.e., elemental analysis, ESI mass spectrometry, 1D and 2D NMR, IR and UV-vis spectroscopies, cyclic voltammetry (CV) and spectroelectrochemistry (SEC). Re-crystallisation of 1 from methanol afforded single crystals of copper(II) complex with monoanionic ligand Cu(L-1)Cl, which could be studied by single crystal X-ray diffraction (SC-XRD). The prepared copper(II) complexes and their metal-free ligands revealed antiproliferative activity against highly resistant cancer cell lines, including triple negative breast cancer cells MDA-MB-231, sensitive COLO-205 and multidrug resistant COLO-320 colorectal adenocarcinoma cell lines, as well as in healthy human lung fibroblasts MRC-5 and compared to those for triapine and doxorubicin. In addition, their ability to reduce the tyrosyl radical in mouse R2 protein of ribonucleotide reductase has been ascertained by EPR spectroscopy and the results were compared with those for triapine.}, keywords = {COMBINATION; IN-VITRO; copper(II); Electrochemistry; PHASE-I; DNA cleavage; ANTIPROLIFERATIVE ACTIVITY; coumarin; Thiosemicarbazones; ribonucleotide reductase; Piperazine; Triapine; TOPOISOMERASE-II; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE 3-AP; ANTICANCER THIOSEMICARBAZONES}, year = {2021}, eissn = {2218-273X}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Buchel, Gabriel E./0000-0002-5055-7099} } @article{MTMT:32201163, title = {Cyano- and Ketone-Containing Selenoesters as Multi-Target Compounds against Resistant Cancers}, url = {https://m2.mtmt.hu/api/publication/32201163}, author = {Szemerédi, Nikoletta and Dobiasová, Simona and Salardón-Jiménez, Noemi and Kincses, Annamária and Nové, Márta and Habibullah, Giyaullah and Sevilla-Hernández, Clotilde and Benito-Lama, Miguel and Alonso-Martínez, Francisco-Javier and Viktorová, Jitka and Spengler, Gabriella and Domínguez-Álvarez, Enrique}, doi = {10.3390/cancers13184563}, journal-iso = {CANCERS}, journal = {CANCERS}, volume = {13}, unique-id = {32201163}, year = {2021}, eissn = {2072-6694}, orcid-numbers = {Salardón-Jiménez, Noemi/0000-0002-2215-804X; Kincses, Annamária/0000-0002-1591-1419; Habibullah, Giyaullah/0000-0001-9455-655X; Sevilla-Hernández, Clotilde/0000-0002-0745-5281; Viktorová, Jitka/0000-0003-0857-153X; Spengler, Gabriella/0000-0001-8085-0950; Domínguez-Álvarez, Enrique/0000-0003-2655-1575} } @article{MTMT:33041580, title = {Pholiols A-D and other triterpenes from Pholiota populnea and their activity against colon carcinoma}, url = {https://m2.mtmt.hu/api/publication/33041580}, author = {Yazdani, Morteza and Hohmann, Judit and Kincses, Annamária and Spengler, Gabriella and Béni, Zoltán and Dékány, Miklós and Ványolós, Attila}, doi = {10.1055/s-0041-1736949}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {87}, unique-id = {33041580}, issn = {0032-0943}, year = {2021}, eissn = {1439-0221}, pages = {1302-1302}, orcid-numbers = {Hohmann, Judit/0000-0002-2887-6392; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Ványolós, Attila/0000-0002-4710-0004} } @article{MTMT:31933965, title = {An insight into the structure of 5-spiro aromatic derivatives of imidazolidine-2,4-dione, a new group of very potent inhibitors of tumor multidrug resistance in T-lymphoma cells}, url = {https://m2.mtmt.hu/api/publication/31933965}, author = {Żesławska, Ewa and Kucwaj-Brysz, Katarzyna and Kincses, Annamária and Spengler, Gabriella and Szymańska, Ewa and Czopek, Anna and Marć, Małgorzata Anna and Kaczor, Aneta and Nitek, Wojciech and Domínguez-Álvarez, Enrique and Latacz, Gniewomir and Kieć-Kononowicz, Katarzyna and Handzlik, Jadwiga}, doi = {10.1016/j.bioorg.2021.104735}, journal-iso = {BIOORG CHEM}, journal = {BIOORGANIC CHEMISTRY}, volume = {109}, unique-id = {31933965}, issn = {0045-2068}, year = {2021}, eissn = {1090-2120}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31315051, title = {Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma}, url = {https://m2.mtmt.hu/api/publication/31315051}, author = {Ali, Wesam and Spengler, Gabriella and Kincses, Annamária and Nové, Márta and Battistelli, Cecilia and Latacz, Gniewomir and Starek, Małgorzata and Dąbrowska, Monika and Honkisz-Orzechowska, Ewelina and Romanelli, Annalisa and Rasile, Manuela Monica and Szymańska, Ewa and Jacob, Claus and Zwergel, Clemens and Handzlik, Jadwiga}, doi = {10.1016/j.ejmech.2020.112435}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {200}, unique-id = {31315051}, issn = {0223-5234}, year = {2020}, eissn = {1768-3254}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419} } @article{MTMT:31392948, title = {2-oxo-1,2-dihydroquinoline-4-carboxylic acid derivatives as potent modulators of ABCB1-related drug resistance of mouse T-lymphoma cells}, url = {https://m2.mtmt.hu/api/publication/31392948}, author = {Baba, Yassir Filali and Misbahi, Houria and Rodi, Youssef Kandri and Ouzidan, Younes and Essassi, El Mokhtar and Vincze, Klaudia and Nové, Márta and Gajdács, Márió and Molnár, József and Spengler, Gabriella and Mazzah, Ahmed}, doi = {10.1016/j.cdc.2020.100501}, journal-iso = {CHEM DATA COLLECT}, journal = {CHEMICAL DATA COLLECTIONS}, volume = {29}, unique-id = {31392948}, year = {2020}, eissn = {2405-8300}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31783358, title = {Antiproliferative Phenanthrenes from Juncus tenuis: Isolation and Diversity-Oriented Semisynthetic Modification}, url = {https://m2.mtmt.hu/api/publication/31783358}, author = {Bús, Csaba and Kúsz, Norbert and Kincses, Annamária and Szemerédi, Nikoletta and Spengler, Gabriella and Bakacsy, László and Purger, Dragica and Berkecz, Róbert and Hohmann, Judit and Hunyadi, Attila and Vasas, Andrea}, doi = {10.3390/molecules25245983}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {25}, unique-id = {31783358}, issn = {1420-3049}, year = {2020}, eissn = {1420-3049}, orcid-numbers = {Bús, Csaba/0000-0002-4515-8317; Kúsz, Norbert/0000-0002-9973-6442; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Bakacsy, László/0000-0003-2593-1795; Purger, Dragica/0000-0003-2480-0777; Berkecz, Róbert/0000-0002-9076-2177; Hohmann, Judit/0000-0002-2887-6392; Hunyadi, Attila/0000-0003-0074-3472; Vasas, Andrea/0000-0002-1818-7702} } @article{MTMT:31392313, title = {Repurposing old drugs to fight multidrug resistant cancers}, url = {https://m2.mtmt.hu/api/publication/31392313}, author = {Dinić, J. and Efferth, T. and García-Sosa, A.T. and Grahovac, J. and Padrón, J.M. and Pajeva, I. and Rizzolio, F. and Saponara, S. and Spengler, Gabriella and Tsakovska, I.}, doi = {10.1016/j.drup.2020.100713}, journal-iso = {DRUG RESIST UPDATE}, journal = {DRUG RESISTANCE UPDATES}, volume = {52}, unique-id = {31392313}, issn = {1368-7646}, abstract = {Overcoming multidrug resistance represents a major challenge for cancer treatment. In the search for new chemotherapeutics to treat malignant diseases, drug repurposing gained a tremendous interest during the past years. Repositioning candidates have often emerged through several stages of clinical drug development, and may even be marketed, thus attracting the attention and interest of pharmaceutical companies as well as regulatory agencies. Typically, drug repositioning has been serendipitous, using undesired side effects of small molecule drugs to exploit new disease indications. As bioinformatics gain increasing popularity as an integral component of drug discovery, more rational approaches are needed. Herein, we show some practical examples of in silico approaches such as pharmacophore modelling, as well as pharmacophore- and docking-based virtual screening for a fast and cost-effective repurposing of small molecule drugs against multidrug resistant cancers. We provide a timely and comprehensive overview of compounds with considerable potential to be repositioned for cancer therapeutics. These drugs are from diverse chemotherapeutic classes. We emphasize the scope and limitations of anthelmintics, antibiotics, antifungals, antivirals, antimalarials, antihypertensives, psychopharmaceuticals and antidiabetics that have shown extensive immunomodulatory, antiproliferative, pro-apoptotic, and antimetastatic potential. These drugs, either used alone or in combination with existing anticancer chemotherapeutics, represent strong candidates to prevent or overcome drug resistance. We particularly focus on outcomes and future perspectives of drug repositioning for the treatment of multidrug resistant tumors and discuss current possibilities and limitations of preclinical and clinical investigations. © 2020 Elsevier Ltd}, keywords = {DEXAMETHASONE; review; human; priority journal; valproic acid; prednisone; antidiabetic agent; antivirus agent; antineoplastic agent; unindexed drug; docetaxel; chloroquine; multidrug resistance; THALIDOMIDE; rituximab; antibiotic agent; Temozolomide; antifungal agent; capecitabine; hydroxychloroquine; antimalarial agent; cost effectiveness analysis; computer model; metformin; antihypertensive agent; hydralazine; itraconazole; sorafenib; psychotropic agent; Molecular docking; vorinostat; pharmacophore; Virtual screening; lenalidomide; anthelmintic agent; pomalidomide; drug repositioning; malignant neoplasm; drug repurposing; abiraterone; niclosamide; Artesunate; Pharmacophore modelling; Clinical cancer trials; Multidrug resistant cancer}, year = {2020}, eissn = {1532-2084}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:31670828, title = {Phytochemical and pharmacological investigation of sea rush}, url = {https://m2.mtmt.hu/api/publication/31670828}, author = {Stefkó, Dóra and Barta, Anita and Kúsz, Norbert and Berkecz, Róbert and Spengler, Gabriella and Annamária, Kincses and Bakacsy, László and Hohmann, Judit and Vasas, Andrea}, booktitle = {Medical Conference for PhD Students and Experts of Clinical Sciences}, unique-id = {31670828}, year = {2020}, pages = {57-58}, orcid-numbers = {Stefkó, Dóra/0000-0002-5435-546X; Kúsz, Norbert/0000-0002-9973-6442; Berkecz, Róbert/0000-0002-9076-2177; Spengler, Gabriella/0000-0001-8085-0950; Bakacsy, László/0000-0003-2593-1795; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} } @article{MTMT:30858898, title = {Solution equilibrium, structural and cytotoxicity studies on Ru(η6-p-cymene) and copper complexes of pyrazolyl thiosemicarbazones}, url = {https://m2.mtmt.hu/api/publication/30858898}, author = {Dömötör, Orsolya and Kiss, Márton Attila and Gál, Gyula Tamás and May, Nóra Veronika and Spengler, Gabriella and Nové, Márta and Gašparović, Ana Čipak and Nagyné Frank, Éva and Enyedy, Éva Anna}, doi = {10.1016/j.jinorgbio.2019.110883}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {202}, unique-id = {30858898}, issn = {0162-0134}, year = {2020}, eissn = {1873-3344}, orcid-numbers = {Dömötör, Orsolya/0000-0001-8736-3215; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Nagyné Frank, Éva/0000-0002-1332-0551; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:31619509, title = {Nitrogen-containing Naringenin Derivatives for Reversing Multidrug Resistance in Cancer}, url = {https://m2.mtmt.hu/api/publication/31619509}, author = {Ferreira, Ricardo J. and Gajdács, Márió and Kincses, Annamária and Spengler, Gabriella and J. V. A. dos Santos, Daniel and Ferreira, Maria-José U.}, doi = {10.1016/j.bmc.2020.115798}, journal-iso = {BIOORGAN MED CHEM}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, volume = {28}, unique-id = {31619509}, issn = {0968-0896}, year = {2020}, eissn = {1464-3391}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31564848, title = {Phenothiazines and Selenocompounds. A Potential Novel Combination Therapy of Multidrug Resistant Cancer}, url = {https://m2.mtmt.hu/api/publication/31564848}, author = {Gajdács, Márió and Nové, Márta and Csonka, Ákos and Varga, Borisz and SANMARTÍN, CARMEN and DOMÍNGUEZ-ÁLVAREZ, ENRIQUE and Spengler, Gabriella}, doi = {10.21873/anticanres.14495}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {40}, unique-id = {31564848}, issn = {0250-7005}, year = {2020}, eissn = {1791-7530}, pages = {4921-4928}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31314654, title = {Search for ABCB1 Modulators Among 2-Amine-5-Arylideneimidazolones as a New Perspective to Overcome Cancer Multidrug Resistance}, url = {https://m2.mtmt.hu/api/publication/31314654}, author = {Kaczor, Aneta and Nové, Márta and Kincses, Annamária and Spengler, Gabriella and Szymańska, Ewa and Latacz, Gniewomir and Handzlik, Jadwiga}, doi = {10.3390/molecules25092258}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {25}, unique-id = {31314654}, issn = {1420-3049}, year = {2020}, eissn = {1420-3049}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31612933, title = {Benzoxazole-Based Metal Complexes to Reverse Multidrug Resistance in Bacteria}, url = {https://m2.mtmt.hu/api/publication/31612933}, author = {Kincses, Annamária and Szabó, Stefánia and Rácz, Bálint and Szemerédi, Nikoletta and Watanabe, Genki and Saijo, Ryosuke and Sekiya, Hiroshi and Tamai, Eiji and Molnár, József and Kawase, Masami and Spengler, Gabriella}, doi = {10.3390/antibiotics9100649}, journal-iso = {ANTIBIOTICS-BASEL}, journal = {ANTIBIOTICS}, volume = {9}, unique-id = {31612933}, year = {2020}, eissn = {2079-6382}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31138211, title = {Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts}, url = {https://m2.mtmt.hu/api/publication/31138211}, author = {Kovács, Dávid and Igaz, Nóra and Marton, Annamária and Rónavári, Andrea and Bélteky, Péter and Bodai, László and Spengler, Gabriella and Tiszlavicz, László and Rázga, Zsolt and Hegyi, Péter and Vizler, Csaba and Boros, Imre Miklós and Kónya, Zoltán and Csontné Kiricsi, Mónika}, doi = {10.1186/s12951-020-0576-x}, journal-iso = {J NANOBIOTECHNOL}, journal = {JOURNAL OF NANOBIOTECHNOLOGY}, volume = {18}, unique-id = {31138211}, year = {2020}, eissn = {1477-3155}, orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; Bodai, László/0000-0001-8411-626X; Spengler, Gabriella/0000-0001-8085-0950; Tiszlavicz, László/0000-0003-1134-6587; Rázga, Zsolt/0000-0003-4717-8482; Hegyi, Péter/0000-0003-0399-7259; Boros, Imre Miklós/0000-0001-8504-9687; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:31749584, title = {Antimicrobial, Anticancer and Multidrug-Resistant Reversing Activity of Novel Oxygen-, Sulfur- and Selenoflavones and Bioisosteric Analogues}, url = {https://m2.mtmt.hu/api/publication/31749584}, author = {Małgorzata, Anna Marć and Kincses, Annamária and Rácz, Bálint and Muhammad, Jawad Nasim and Muhammad, Sarfraz and Carlos, Lázaro-Milla and Enrique, Domínguez-Álvarez and Claus, Jacob and Spengler, Gabriella and Pedro, Almendros}, doi = {10.3390/ph13120453}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {13}, unique-id = {31749584}, year = {2020}, eissn = {1424-8247}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:31386114, title = {Non-Antibiotic Pharmaceuticals as Quorum Sensing Inhibitors: Results from a Disk Diffusion-Based In Vitro Study}, url = {https://m2.mtmt.hu/api/publication/31386114}, author = {Gajdács, Márió and Spengler, Gabriella}, booktitle = {21st Iinternational Medical Esperanto Congress: COVID-19 pandemic : history, current status and consequences}, unique-id = {31386114}, year = {2020}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:31303690, title = {Drug repositioning as a possible strategy to combat bacterial infections: evaluation of non-antibiotic human therapeutics as quorum-sensing inhibitors}, url = {https://m2.mtmt.hu/api/publication/31303690}, author = {Gajdács, Márió and Spengler, Gabriella}, booktitle = {30th European Congress of Clinical Microbiology and Infectious Diseases: Abstract Book 2020}, unique-id = {31303690}, year = {2020}, pages = {1115-1115}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31313563, title = {An 8-hydroxyquinoline-proline hybrid with multidrug resistance reversal activity and the solution chemistry of its half-sandwich organometallic Ru and Rh complexes}, url = {https://m2.mtmt.hu/api/publication/31313563}, author = {Mészáros, János Péter and Poljarević, Jelena and Szatmári, István and Csuvik, Oszkár and Fülöp, Ferenc and Szoboszlai, Norbert and Spengler, Gabriella and Enyedy, Éva Anna}, doi = {10.1039/d0dt01256d}, journal-iso = {J CHEM SOC DALTON TRANS}, journal = {JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS}, volume = {49}, unique-id = {31313563}, issn = {1472-7773}, year = {2020}, pages = {7977-7992}, orcid-numbers = {Mészáros, János Péter/0000-0001-6301-5259; Szatmári, István/0000-0002-8571-5229; Fülöp, Ferenc/0000-0003-1066-5287; Szoboszlai, Norbert/0000-0002-3991-3996; Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:31407523, title = {Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters}, url = {https://m2.mtmt.hu/api/publication/31407523}, author = {Milunović, Miljan N. M. and Palamarciuc, Oleg and Sirbu, Angela and Shova, Sergiu and Dumitrescu, Dan and Dvoranová, Dana and Rapta, Peter and Petrasheuskaya, Tatsiana and Enyedy, Éva Anna and Spengler, Gabriella and Ilic, Marija and Sitte, Harald H. and Lubec, Gert and Arion, Vladimir B.}, doi = {10.3390/biom10091213}, journal-iso = {BIOMOLECULES}, journal = {BIOMOLECULES}, volume = {10}, unique-id = {31407523}, issn = {2218-273X}, year = {2020}, eissn = {2218-273X}, pages = {1213-1243}, orcid-numbers = {Enyedy, Éva Anna/0000-0002-8058-8128; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31281334, title = {Biofilm Eradication by Symmetrical Selenoesters for Food-Borne Pathogens}, url = {https://m2.mtmt.hu/api/publication/31281334}, author = {Nové, Márta and Kincses, Annamária and Szalontai, Beatrix and Rácz, Bálint and Blair, Jessica M. A. and González-Prádena, Ana and Benito-Lama, Miguel and Domínguez-Álvarez, Enrique and Spengler, Gabriella}, doi = {10.3390/microorganisms8040566}, journal-iso = {MICROORGANISMS}, journal = {MICROORGANISMS}, volume = {8}, unique-id = {31281334}, issn = {2076-2607}, year = {2020}, eissn = {2076-2607}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31033042, title = {The Role of Efflux Pumps and Environmental pH in Bacterial Multidrug Resistance}, url = {https://m2.mtmt.hu/api/publication/31033042}, author = {Nové, Márta and Kincses, Annamária and Molnár, József and Amaral, Leonard and Spengler, Gabriella}, doi = {10.21873/invivo.11746}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {34}, unique-id = {31033042}, issn = {0258-851X}, year = {2020}, eissn = {1791-7549}, pages = {65-71}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31367278, title = {Salicylaldehyde thiosemicarbazone copper complexes: impact of hybridization with estrone on cytotoxicity, solution stability and redox activity}, url = {https://m2.mtmt.hu/api/publication/31367278}, author = {Petrasheuskaya, Tatsiana and Kiss, Márton Attila and Dömötör, Orsolya and Holczbauer, Tamás and May, Nóra Veronika and Spengler, Gabriella and Kincses, Annamária and Čipak Gašparović, Ana and Nagyné Frank, Éva and Enyedy, Éva Anna}, doi = {10.1039/d0nj01070g}, journal-iso = {NEW J CHEM}, journal = {NEW JOURNAL OF CHEMISTRY}, volume = {44}, unique-id = {31367278}, issn = {1144-0546}, year = {2020}, eissn = {1369-9261}, pages = {12154-12168}, orcid-numbers = {Dömötör, Orsolya/0000-0001-8736-3215; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419; Nagyné Frank, Éva/0000-0002-1332-0551; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:31856961, title = {N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H3 receptor and cancer resistance proteins}, url = {https://m2.mtmt.hu/api/publication/31856961}, author = {Szczepańska, K. and Kincses, Annamária and Vincze, K. and Szymańska, E. and Latacz, G. and Kuder, K.J. and Stark, H. and Spengler, Gabriella and Handzlik, J. and Kieć-Kononowicz, K.}, doi = {10.1016/j.bmcl.2020.127522}, journal-iso = {BIOORG MED CHEM LETT}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, volume = {30}, unique-id = {31856961}, issn = {0960-894X}, abstract = {Taking into account that multidrug resistance (MDR) is the main cause for chemotherapeutic failure in cancer treatment, the ability of novel histamine H3 receptor ligands to reverse the cancer MDR was evaluated, using the ABCB1 efflux pump inhibition assay in mouse MDR T-lymphoma cells. The most active compounds displayed significant cytotoxic and antiproliferative effects as well as a very potent MDR efflux pump inhibitory action, 3–5-fold stronger than that of reference inhibitor verapamil. Although these compounds possess weak antagonistic properties against histamine H3 receptors, they are valuable pharmacological tools in the search for novel anticancer molecules. Furthermore, for the most active compounds, an insight into mechanisms of action using either, the luminescent Pgp-Glo™ Assay in vitro or docking studies to human Pgp, was performed. © 2020 Elsevier Ltd}, keywords = {LIPOPHILICITY; GENE; CANCER; ARTICLE; MOUSE; controlled study; nonhuman; animal experiment; animal cell; in vitro study; verapamil; piperazine derivative; concentration response; unclassified drug; drug efficacy; drug mechanism; drug cytotoxicity; drug transport; Drug targeting; drug structure; multidrug resistance; oncoprotein; ANTIPROLIFERATIVE ACTIVITY; structure activity relation; cancer resistance; drug synthesis; rhodamine; drug potency; drug binding site; drug purity; MTT assay; thioridazine; Molecular docking; histamine H3 receptor; lymphoma cell; ABCB1; Antiproliferative; CANCER RESISTANCE PROTEIN; Piperazine; MDR efflux pumps; IC50; cytotoxicity assay; ABC transporter subfamily B; ABCB1 gene; Histamine H3 receptor ligands; T-Lymphoma; pyrazin 2 yl; pyridin 2 yl; pyridin 3 yl}, year = {2020}, eissn = {1464-3405}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31780199, title = {Ketone- and Cyano-Selenoesters to Overcome Efflux Pump, Quorum-Sensing, and Biofilm-Mediated Resistance}, url = {https://m2.mtmt.hu/api/publication/31780199}, author = {Szemerédi, Nikoletta and Kincses, Annamária and Rehorova, Katerina and Hoang, Lan and Salardón-Jiménez, Noemi and Sevilla-Hernández, Clotilde and Viktorová, Jitka and Domínguez-Álvarez, Enrique and Spengler, Gabriella}, doi = {10.3390/antibiotics9120896}, journal-iso = {ANTIBIOTICS-BASEL}, journal = {ANTIBIOTICS}, volume = {9}, unique-id = {31780199}, year = {2020}, eissn = {2079-6382}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31602087, title = {Squalenoylated Nanoparticle Pro-Drugs of Adjuvant Antitumor 11α-Hydroxyecdysteroid 2,3-Acetonides Act as Cytoprotective Agents Against Doxorubicin and Paclitaxel}, url = {https://m2.mtmt.hu/api/publication/31602087}, author = {Vágvölgyi, Máté and Bélteky, Péter and Bogdán, Dóra and Nové, Márta and Spengler, Gabriella and Latif, Ahmed Dhahir and Zupkó, István and Gáti, Tamás and Tóth, Gábor and Kónya, Zoltán and Hunyadi, Attila}, doi = {10.3389/fphar.2020.552088}, journal-iso = {FRONT PHARMACOL}, journal = {FRONTIERS IN PHARMACOLOGY}, volume = {11}, unique-id = {31602087}, year = {2020}, eissn = {1663-9812}, orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Bogdán, Dóra/0000-0003-4455-8914; Spengler, Gabriella/0000-0001-8085-0950; Zupkó, István/0000-0003-3243-5300; Gáti, Tamás/0000-0003-4455-8914; Kónya, Zoltán/0000-0002-9406-8596; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:30706172, title = {Selenoesters and Selenoanhydrides as Novel Agents Against Resistant Breast Cancer}, url = {https://m2.mtmt.hu/api/publication/30706172}, author = {Csonka, Andrea and Kincses, Annamária and Nové, Márta and Zsófia, Vadas and Carmen, Sanmartín and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, doi = {10.21873/anticanres.13526}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {39}, unique-id = {30706172}, issn = {0250-7005}, year = {2019}, eissn = {1791-7530}, pages = {3777-3783}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:30807017, title = {Biofilm inhibiting activity of selenium compounds}, url = {https://m2.mtmt.hu/api/publication/30807017}, author = {Kincses, Annamária and Enrique, Domínguez-Álvarez and Carmen, Sanmartín and Helen, E. Smith and Jessica, M. A. Blair and Nové, Márta and Spengler, Gabriella}, unique-id = {30807017}, year = {2019}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30734143, title = {THE ROLE OF PH REGARDING ANTIBIOTIC SUSCEPTIBILITY OF URINARY TRACT PATHOGENS}, url = {https://m2.mtmt.hu/api/publication/30734143}, author = {Kincses, Annamária and Orsolya, Vásárhelyi and Nové, Márta and Zsoldiné Urbán, Edit and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {Suppl.1.}, unique-id = {30734143}, issn = {1217-8950}, year = {2019}, eissn = {1588-2640}, pages = {49-50}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30671750, title = {Novel latonduine derived proligands and their copper(II) complexes show cytotoxicity in the nanomolar range in human colon adenocarcinoma cells and in vitro cancer selectivity}, url = {https://m2.mtmt.hu/api/publication/30671750}, author = {Bacher, Felix and Wittmann, Christopher and Nové, Márta and Spengler, Gabriella and Marć, Małgorzata Anna and Enyedy, Éva Anna and Darvasiova, Denisa and Rapta, P. and Reiner, Thomas and Arion, Vladimir}, doi = {10.1039/c9dt01238a}, journal-iso = {J CHEM SOC DALTON TRANS}, journal = {JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS}, volume = {48}, unique-id = {30671750}, issn = {1472-7773}, year = {2019}, pages = {10464-10478}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:30981329, title = {New Chalcone Derivative Inhibits ABCB1 in Multidrug Resistant T-cell Lymphoma and Colon Adenocarcinoma Cells}, url = {https://m2.mtmt.hu/api/publication/30981329}, author = {ČIŽMÁRIKOVÁ, MARTINA and TAKÁČ, PETER and Spengler, Gabriella and Kincses, Annamária and Nové, Márta and VILKOVÁ, MÁRIA and MOJŽIŠ, JÁN}, doi = {10.21873/anticanres.13864}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {39}, unique-id = {30981329}, issn = {0250-7005}, year = {2019}, eissn = {1791-7530}, pages = {6499-6505}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419} } @article{MTMT:30826705, title = {The Search for Histamine H 4 Receptor Ligands with Anticancer Activity among Novel (Thio)urea Derivatives}, url = {https://m2.mtmt.hu/api/publication/30826705}, author = {Domínguez‐Álvarez, Enrique and Łażewska, Dorota and Szabó, Zsanett and Hagenow, Stefanie and Reiner, David and Gajdács, Márió and Spengler, Gabriella and Stark, Holger and Handzlik, Jadwiga and Kieć‐Kononowicz, Katarzyna}, doi = {10.1002/slct.201902747}, journal-iso = {CHEMISTRYSELECT}, journal = {CHEMISTRYSELECT}, volume = {4}, unique-id = {30826705}, issn = {2365-6549}, year = {2019}, eissn = {2365-6549}, pages = {10943-10952}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:32893957, title = {Pirazolo- és szaliciladehid-tioszemikarbazon ligandumok Cu(II) és Ru(II)(p-cimol) komplexei: szintézis, rákellenes aktivitás, stabilitás és szerkezet}, url = {https://m2.mtmt.hu/api/publication/32893957}, author = {Dömötör, Orsolya and Tatsiana, Petrasheuskaya and Gál, G. Tamás and May, Nóra Veronika and Nové, Márta and Kincses, Annamária and Spengler, Gabriella and Ana, Čipak Gašparović and Kiss, Márton Attila and Nagyné Frank, Éva and Enyedy, Éva A.}, booktitle = {53. Komplexkémiai Kollokvium Az MKE Komplexkémiai Szakcsoportjának és az MTA Koordinációs Kémiai Munkabizottságának a rendezvénye Részletes programfüzet, Előadás-összefoglalók}, unique-id = {32893957}, year = {2019}, pages = {E6}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Nagyné Frank, Éva/0000-0002-1332-0551} } @article{MTMT:30409871, title = {Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents}, url = {https://m2.mtmt.hu/api/publication/30409871}, author = {Duca, Gheorghe and Aricu, Aculina and Kuchkova, Kaleria and Secara, Elena and Barba, Alic and Dragalin, Ion and Ungur, Nicon and Spengler, Gabriella}, doi = {10.1080/14786419.2018.1516658}, journal-iso = {NAT PROD RES}, journal = {NATURAL PRODUCT RESEARCH}, volume = {33}, unique-id = {30409871}, issn = {1478-6419}, abstract = {Using sclareol and sclareolide as starting materials, the guanidine derivatives of 12-amino-11-dihomodrimane-8α-ol and 13-amino-14,15-bis-dinorlabd-8(9)-ene were synthesized by the reaction of the corresponding amines with sodium hydrogencyanamide in ethanol - water solution. Monoacyl- and diacylguanidines were prepared from activated with N,N-carbonyldiimidazole Δ8,9-bicyclohomofarnesenoic acid by the reaction with guanidine. Their structures were confirmed by the 1H and 13C NMR, IR spectral and elemental analysis data. The compounds 12, 13 and 15 were screened for their antiproliferative and cytotoxicity activities against Colo 205, Colo 320 and MRC 5 human lung fibroblasts with respect to standard drug, Cisplatin. The compounds 12 and 15 exhibits excellent results than positive control. Hence these two compounds may be act as drug lead molecules in cancer chemotherapy.}, keywords = {synthesis; ANTIPROLIFERATIVE ACTIVITY; Guanidines; Terpenoids; 14,15-Bis-norlabdane; dihomodrimane}, year = {2019}, eissn = {1478-6427}, pages = {3052-3056}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30637624, title = {Comparative solution studies and cytotoxicity of gallium(III) and iron(III) complexes of 3-hydroxy-2(1H)-pyridinones}, url = {https://m2.mtmt.hu/api/publication/30637624}, author = {Enyedy, Éva Anna and Mészáros, János Péter and Spengler, Gabriella and Hanif, Muhammad and Hartinger, Christian G.}, doi = {10.1016/j.poly.2019.04.010}, journal-iso = {POLYHEDRON}, journal = {POLYHEDRON}, volume = {172}, unique-id = {30637624}, issn = {0277-5387}, year = {2019}, eissn = {1873-3719}, pages = {141-147}, orcid-numbers = {Enyedy, Éva Anna/0000-0002-8058-8128; Mészáros, János Péter/0000-0001-6301-5259; Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:30759162, title = {Solution equilibria of various antitumor half-sandwich organometallic complexes of 8-hydroxyquinolines and 2-picolinates: structure, stability and activity}, url = {https://m2.mtmt.hu/api/publication/30759162}, author = {Enyedy, Éva Anna and János, P. Mészáros and Dömötör, Orsolya and Jelena, M. Poljarević and May, Nóra Veronika and G., Tamás Gál and István, Szatmári and Ferenc, Fülöp and Spengler, Gabriella}, unique-id = {30759162}, year = {2019}, orcid-numbers = {Enyedy, Éva Anna/0000-0002-8058-8128; Dömötör, Orsolya/0000-0001-8736-3215; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30760585, title = {Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine}, url = {https://m2.mtmt.hu/api/publication/30760585}, author = {Fabian, Lentz and Norbert, Reiling and Spengler, Gabriella and Kincses, Annamária and Csonka, Andrea and Molnár, József and Andreas, Hilgeroth}, doi = {10.3390/molecules24162873}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {24}, unique-id = {30760585}, issn = {1420-3049}, year = {2019}, eissn = {1420-3049}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419} } @CONFERENCE{MTMT:31192702, title = {Natural product inspired chemical approaches against MDR cancer}, url = {https://m2.mtmt.hu/api/publication/31192702}, author = {Fási, Laura and Vágvölgyi, Máté and Latif, Ahmed Dhahir and Issaadi, Halima Meriem and Zoofishan, Zoofishan and Zupkó, István and Spengler, Gabriella and Martins, Ana and Hunyadi, Attila}, booktitle = {New Diagnostic and Therapeutic Tools against Multidrug-Resistant Tumours}, unique-id = {31192702}, year = {2019}, pages = {12-13}, orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Zupkó, István/0000-0003-3243-5300; Spengler, Gabriella/0000-0001-8085-0950; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:30929822, title = {Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and Selenoanhydrides}, url = {https://m2.mtmt.hu/api/publication/30929822}, author = {Spengler, Gabriella and Kincses, Annamária and Mosolygó, Tímea and Małgorzata, Anna Marć and Nové, Márta and Gajdács, Márió and Carmen, Sanmartín and Helen, E McNeil and Jessica, MA Blair and Enrique, Domínguez-Álvarez}, doi = {10.3390/molecules24234264}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {24}, unique-id = {30929822}, issn = {1420-3049}, year = {2019}, eissn = {1420-3049}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Gajdács, Márió/0000-0003-1270-0365} } @article{MTMT:30734126, title = {NIGELLA SATIVA ESSENTIAL OIL AS POTENTIAL SOURCE OF ANTIMICROBIAL AGENTS AGAINST STAPHYLOCOCCUS AUREUS}, url = {https://m2.mtmt.hu/api/publication/30734126}, author = {Spengler, Gabriella and Mouwakeh, Ahmad and Kincses, Annamária and Nové, Márta and Mosolygó, Tímea and Mohácsiné Farkas, Csilla and Kiskó, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {Suppl.1.}, unique-id = {30734126}, issn = {1217-8950}, year = {2019}, eissn = {1588-2640}, pages = {188-189}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X} } @article{MTMT:31182366, title = {Standard operating procedure (SOP) for disk diffusion-based quorum sensing inhibition assays}, url = {https://m2.mtmt.hu/api/publication/31182366}, author = {Gajdács, Márió and Spengler, Gabriella}, doi = {10.33892/aph.2019.89.117-125}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {89}, unique-id = {31182366}, issn = {0001-6659}, year = {2019}, eissn = {1587-1495}, pages = {117-125}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:33153883, title = {Phytochemical and pharmacological analysis of two Iranian plants, Ducrosia anethifolia and Eremurus persicus}, url = {https://m2.mtmt.hu/api/publication/33153883}, author = {Mottaghipisheh, Javad and Márta, Nové and Spengler, Gabriella and Kúsz, Norbert and Hohmann, Judit and Csupor, Dezső}, booktitle = {Proceedings of the 25th International Symposium on Analytical and Environmental Problems}, unique-id = {33153883}, year = {2019}, pages = {63-64}, orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189; Spengler, Gabriella/0000-0001-8085-0950; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:30709696, title = {Reversal of multi-drug resistance and Anti-proliferative activities in mouse lymphoma cells by extracts/fractions of Picea smithiana (wall) boiss}, url = {https://m2.mtmt.hu/api/publication/30709696}, author = {Kashif, Bashir and Bashir, Ahmad and Abdur, Rauf and Amjad, Hussain and Gajdács, Márió and Molnár, József and Spengler, Gabriella and Yahia, N. Mabkhot and Abdul Rhman, Asayari and H., Algarni}, journal-iso = {BIOCELL}, journal = {BIOCELL}, volume = {43}, unique-id = {30709696}, issn = {0327-9545}, year = {2019}, eissn = {1667-5746}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:30706107, title = {Metal complexes as novel antibacterial agents against Staphylococcus aureus}, url = {https://m2.mtmt.hu/api/publication/30706107}, author = {Kincses, Annamária and Szabó, Stefánia and Mosolygó, Tímea and Saijo, Ryosuke and Kawase, Masami and Spengler, Gabriella}, unique-id = {30706107}, year = {2019}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950} } @inbook{MTMT:30717898, title = {Szelénvegyületek efflux pumpa és biofilm gátló hatásának vizsgálata Salmonella Typhimurium törzseken}, url = {https://m2.mtmt.hu/api/publication/30717898}, author = {Kincses, Annamária and Spengler, Gabriella}, booktitle = {Tudományos eredmények a nagyvilágból - bővített kiadás}, unique-id = {30717898}, year = {2019}, pages = {74-79}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:31011847, title = {The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors}, url = {https://m2.mtmt.hu/api/publication/31011847}, author = {Gajdács, Márió and Spengler, Gabriella}, doi = {10.3390/antibiotics8040270}, journal-iso = {ANTIBIOTICS-BASEL}, journal = {ANTIBIOTICS}, volume = {8}, unique-id = {31011847}, year = {2019}, eissn = {2079-6382}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30865339, title = {Establishing standard operating procedures (SOP) for disk diffusion quorum sensing inhibition assay}, url = {https://m2.mtmt.hu/api/publication/30865339}, author = {Gajdács, Márió and Molnár, József and Spengler, Gabriella}, journal-iso = {J Infec Dis Treat}, journal = {Journal of Infectious Diseases and Treatment}, volume = {5}, unique-id = {30865339}, year = {2019}, eissn = {2472-1093}, pages = {40-40}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30731348, title = {Metal-Based Antimicrobial Strategies: An In Vitro Study on the Efficacy of Hydrazone-Based Transition Metal Complexes}, url = {https://m2.mtmt.hu/api/publication/30731348}, author = {Gajdács, Márió and József, Magyari and Kincses, Annamária and Nové, Márta and Mosolygó, Tímea and Berta, Barta Holló and Katalin, Mészáros Szécsényi and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {66}, unique-id = {30731348}, issn = {1217-8950}, year = {2019}, eissn = {1588-2640}, pages = {134-135}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30731239, title = {Pharmaceutical Compounds as Quorum Sensing (Qs) Inhibitors}, url = {https://m2.mtmt.hu/api/publication/30731239}, author = {Gajdács, Márió and Szegedi, Ernő and Molnár, József and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {66}, unique-id = {30731239}, issn = {1217-8950}, year = {2019}, eissn = {1588-2640}, pages = {30-31}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30731232, title = {Quorum Sensing Inhibition by Sulfur and Selenium-Containing Organochalcogens: A Comparative In Vitro Study}, url = {https://m2.mtmt.hu/api/publication/30731232}, author = {Gajdács, Márió and Dorota, Lazevska and Katarzyna, Kiec-Kononowicz and Carmen, Sanmartín and Jadwiga, Handzlik and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {66}, unique-id = {30731232}, issn = {1217-8950}, year = {2019}, eissn = {1588-2640}, pages = {29-30}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30734081, title = {Antibacterial effect of diazine-ring containing hydrazones and their metal complexes}, url = {https://m2.mtmt.hu/api/publication/30734081}, author = {Nové, Márta and Kincses, Annamária and Mosolygó, Tímea and Ayman, El-Farouki and József, Magyari and Berta, Holló Barta and Burián, Katalin and Katalin, Szécsényi Mészáros and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {66}, unique-id = {30734081}, issn = {1217-8950}, year = {2019}, eissn = {1588-2640}, pages = {75-76}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Burián, Katalin/0000-0003-1300-2374; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30483477, title = {Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone}, url = {https://m2.mtmt.hu/api/publication/30483477}, author = {Mészáros, János Péter and Poljarevic, Jelena M. and Gál, Gyula Tamás and May, Nóra Veronika and Spengler, Gabriella and Enyedy, Éva Anna}, doi = {10.1016/j.jinorgbio.2019.02.015}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {195}, unique-id = {30483477}, issn = {0162-0134}, abstract = {Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η 5 -C 5 Me 5 )(H 2 O) 3 ] 2+ . Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η 6 ‑p‑cymene), Ru(η 6 ‑toluene) complexes were also studied. 1 H NMR, UV–visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η 6 ‑p‑cymene) > Ru(η 6 ‑toluene) > Rh(η 5 -C 5 Me 5 ). Despite this order, the highest extent of complex formation is seen for the Rh(η 5 -C 5 Me 5 ) complexes at pH 7.4. Formation constant of [Rh(η 5 -C 5 Me 5 )(H 2 curcumin)(H 2 O)] + reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic cations. © 2019}, keywords = {CYTOTOXICITY; Solution stability; CURCUMIN; Half-sandwich complexes; x-ray crystal structures}, year = {2019}, eissn = {1873-3344}, pages = {91-100}, orcid-numbers = {Mészáros, János Péter/0000-0001-6301-5259; May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:30777928, title = {Cucurbalsaminones A–C, Rearranged Triterpenoids with a 5/6/3/6/5-Fused Pentacyclic Carbon Skeleton from Momordica balsamina , as Multidrug Resistance Reversers}, url = {https://m2.mtmt.hu/api/publication/30777928}, author = {Mónico, Andreia and Ramalhete, Cátia and André, Vânia and Spengler, Gabriella and Mulhovo, Silva and Duarte, M. Teresa and Ferreira, Maria-José U.}, doi = {10.1021/acs.jnatprod.9b00019}, journal-iso = {J NAT PROD}, journal = {JOURNAL OF NATURAL PRODUCTS}, volume = {82}, unique-id = {30777928}, issn = {0163-3864}, year = {2019}, eissn = {1520-6025}, pages = {2138-2143}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:30706104, title = {Antibacterial effect of diazine-ring containing hydrazones and their metal complexes}, url = {https://m2.mtmt.hu/api/publication/30706104}, author = {Mosolygó, Tímea and Kincses, Annamária and Nové, Márta and El-Farouki, Ayman and Magyari, József and Barta, Holló Berta and Mészáros, Szécsényi Katalin and Spengler, Gabriella}, unique-id = {30706104}, year = {2019}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:30706100, title = {Antimicrobial effect of phenothiazines alone, and in combination with antibiotics in cases of Chlamydia infection}, url = {https://m2.mtmt.hu/api/publication/30706100}, author = {Mosolygó, Tímea and Borbély, Bence and Szatmári, Marion and Varga, Borisz and Kincses, Annamária and Spengler, Gabriella}, unique-id = {30706100}, year = {2019}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30811942, title = {Bioactive Compounds of Nigella sativa Essential Oil as Antibacterial Agents against Chlamydia trachomatis D}, url = {https://m2.mtmt.hu/api/publication/30811942}, author = {Mosolygó, Tímea and Mouwakeh, Ahmad and Hussein Ali, Munira and Kincses, Annamária and Mohácsiné Farkas, Csilla and Kiskó, Gabriella and Spengler, Gabriella}, doi = {10.3390/microorganisms7090370}, journal-iso = {MICROORGANISMS}, journal = {MICROORGANISMS}, volume = {7}, unique-id = {30811942}, issn = {2076-2607}, year = {2019}, eissn = {2076-2607}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30645681, title = {Selenocompounds as Novel Antibacterial Agents and Bacterial Efflux Pump Inhibitors}, url = {https://m2.mtmt.hu/api/publication/30645681}, author = {Mosolygó, Tímea and Kincses, Annamária and Csonka, Andrea and Tönki, Ádám Szabó and Witek, Karolina and Sanmartín, Carmen and Marć, Małgorzata Anna and Handzlik, Jadwiga and Kieć-Kononowicz, Katarzyna and Domínguez-Álvarez, Enrique and Spengler, Gabriella}, doi = {10.3390/molecules24081487}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {24}, unique-id = {30645681}, issn = {1420-3049}, year = {2019}, eissn = {1420-3049}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:30811833, title = {Antibiotic resistance inhibitors of Nigella sativa essential oil against Listeria monocytogenes}, url = {https://m2.mtmt.hu/api/publication/30811833}, author = {Ahmad, MOUWAKEH and Telbisz, Á. and Spengler, Gabriella and Mohácsiné Farkas, Csilla and Kiskó, Gabriella}, booktitle = {The Science of Food Safety – What’s our Future? FSAI SCIENCE CONFERENCE 2019}, unique-id = {30811833}, year = {2019}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30409867, title = {Nigella sativa essential oil and its bioactive compounds as resistance modifiers against Staphylococcus aureus}, url = {https://m2.mtmt.hu/api/publication/30409867}, author = {Mouwakeh, Ahmad and Kincses, Annamária and Nové, Márta and Mosolygó, Tímea and Mohácsiné Farkas, Csilla and Kiskó, Gabriella and Spengler, Gabriella}, doi = {10.1002/ptr.6294}, journal-iso = {PHYTOTHER RES}, journal = {PHYTOTHERAPY RESEARCH}, volume = {33}, unique-id = {30409867}, issn = {0951-418X}, abstract = {Nigella sativa essential oil (EO) and its compounds (thymoquinone, carvacrol, and p-cymene) have a broad antimicrobial spectrum. The aim of this study was to investigate the antimicrobial and resistance modifying activity of N. sativa EO, thymoquinone, carvacrol, and p-cymene against one methicillin susceptible and one methicillin resistant Staphylococcus aureus strain. N. sativa EO, thymoquinone, carvacrol, and p-cymene were assessed for antimicrobial activity and modulation of antimicrobial resistance (by broth microdilution), inhibition of antimicrobial efflux (by ethidium bromide [EtBr] accumulation assay), relative expression of mepA gene (by real-time reverse transcriptase quantitative polymerase chain reaction), membrane disrupting effect (by LIVE/DEAD BacLight™ Kit), and finally antibiofilm activity (by the crystal violet assay). Both strains of S. aureus were susceptible to N. sativa EO, thymoquinone, and carvacrol. N. sativa EO and carvacrol induced the increase of EtBr accumulated by both S. aureus strains. Membrane integrity of ATCC strain was disrupted by carvacrol and p-cymene, whereas for the methicillin resistant S. aureus (MRSA) strain the membrane integrity was disrupted by each compound. N. sativa EO and its bioactive compounds such as carvacrol and p-cymene could be applied as resistance modifiers in MRSA strains.}, keywords = {ANTIBACTERIAL; Staphylococcus aureus; Biofilm; Nigella sativa essential oil; efflux pump inhibitor (EPI)}, year = {2019}, eissn = {1099-1573}, pages = {1010-1018}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30626034, title = {Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria}, url = {https://m2.mtmt.hu/api/publication/30626034}, author = {Nasim, Muhammad Jawad and Witek, Karolina and Kincses, Annamária and Abdin, Ahmad Yaman and Żesławska, Ewa and Marć, Małgorzata Anna and Gajdács, Márió and Spengler, Gabriella and Nitek, Wojciech and Latacz, Gniewomir and Karczewska, Elżbieta and Kieć-Kononowicz, Katarzyna and Handzlik, Jadwiga and Jacob, Claus}, doi = {10.1039/c9nj00563c}, journal-iso = {NEW J CHEM}, journal = {NEW JOURNAL OF CHEMISTRY}, volume = {43}, unique-id = {30626034}, issn = {1144-0546}, year = {2019}, eissn = {1369-9261}, pages = {6021-6031}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30777937, title = {Effective MDR reversers through phytochemical study of Euphorbia boetica}, url = {https://m2.mtmt.hu/api/publication/30777937}, author = {Neto, Sara and Duarte, Noélia and Pedro, Cecília and Spengler, Gabriella and Molnár, József and Ferreira, Maria‐José U.}, doi = {10.1002/pca.2841}, journal-iso = {PHYTOCHEM ANALYSIS}, journal = {PHYTOCHEMICAL ANALYSIS}, volume = {30}, unique-id = {30777937}, issn = {0958-0344}, year = {2019}, eissn = {1099-1565}, pages = {498-511}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Ferreira, Maria‐José U./0000-0002-8742-1486} } @article{MTMT:31192713, title = {Bio-guided phytochemical study of Plectranthus mutabilis Codd.}, url = {https://m2.mtmt.hu/api/publication/31192713}, author = {Ntungwe, E and Isca, V and Vágvölgyi, Máté and Spengler, Gabriella and Hunyadi, Attila and Rijo, P}, doi = {10.1055/s-0039-3399860}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {18}, unique-id = {31192713}, issn = {0032-0943}, year = {2019}, eissn = {1439-0221}, pages = {1474-1474}, orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Spengler, Gabriella/0000-0001-8085-0950; Hunyadi, Attila/0000-0003-0074-3472} } @CONFERENCE{MTMT:32893996, title = {Studies on copper(II) and organoruthenium(II) complexes of pyrazolo-thiosemicarbazones: anticancer activity, structure and stability}, url = {https://m2.mtmt.hu/api/publication/32893996}, author = {Orsolya, Dömötör and G., Tamás Gál and Nóra, V. May and Spengler, Gabriella and Kiss, Márton Attila and Nagyné Frank, Éva and Éva, A. Enyedy}, booktitle = {ISMEC 2019 International Symposium on Metal Complexes BOOK OF ABSTRACTS}, unique-id = {32893996}, year = {2019}, pages = {101}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Nagyné Frank, Éva/0000-0002-1332-0551} } @article{MTMT:30614994, title = {A rák elleni modern immunterápia}, url = {https://m2.mtmt.hu/api/publication/30614994}, author = {Spengler, Gabriella}, journal-iso = {MAGY KEM LAP}, journal = {MAGYAR KÉMIKUSOK LAPJA}, volume = {74}, unique-id = {30614994}, issn = {0025-0163}, year = {2019}, eissn = {1588-1199}, pages = {42-43}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30409868, title = {Organoselenium Compounds as Novel Adjuvants of Chemotherapy Drugs-A Promising Approach to Fight Cancer Drug Resistance}, url = {https://m2.mtmt.hu/api/publication/30409868}, author = {Spengler, Gabriella and Gajdács, Márió and Marć, Małgorzata Anna and Domínguez-Álvarez, Enrique and Sanmartín, Carmen}, doi = {10.3390/molecules24020336}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {24}, unique-id = {30409868}, issn = {1420-3049}, abstract = {Malignant diseases present a serious public health burden and their treatment with traditional chemotherapy cannot be considered an all-round solution, due to toxic side effects. Selenium compounds (Se-compounds) have received substantial attention in medicinal chemistry, especially in experimental chemotherapy, both as cytotoxic agents and adjuvants in chemotherapy. A checkerboard microplate method was applied to study the drug interactions of Se-compounds and clinically relevant chemotherapeutic drugs against the multidrug-resistant (MDR) subtype of mouse t-lymphoma cells overexpressing the ABCB1 transporter. Se-compounds showed synergistic interactions with chemotherapeutic agents targeting the topoisomerase enzymes or the microtubule apparatus. The ketone-containing selenoesters showed synergism at lower concentrations (1.25 µM). Most of the tested compounds interacted antagonistically with alkylating agents and verapamil. A thiophene-containing Se-compound showed synergism with all tested drugs, except cisplatin. While the exact mechanism of drug interactions is yet unknown, the potency of the selenocompounds as efflux pump inhibitors or the potentiation of their efficacy as reactive oxygen species modulators may play a role in their complementary activity against the tested MDR lymphoma cell line.}, keywords = {COMBINATION; doxorubicin; Selenium; LYMPHOMA; Anticancer; topotecan; checkerboard}, year = {2019}, eissn = {1420-3049}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Gajdács, Márió/0000-0003-1270-0365} } @article{MTMT:30405220, title = {Antifibrotic effect of mitomycin-C on human vocal cord fibroblasts}, url = {https://m2.mtmt.hu/api/publication/30405220}, author = {Szabó, Diána and Kovács, Dávid and Endrész, Valéria and Igaz, Nóra and Jenovai, Kitti and Spengler, Gabriella and Tiszlavicz, László and Molnár, József and Burián, Katalin and Csontné Kiricsi, Mónika and Rovó, László}, doi = {10.1002/lary.27657}, journal-iso = {LARYNGOSCOPE}, journal = {LARYNGOSCOPE}, volume = {129}, unique-id = {30405220}, issn = {0023-852X}, year = {2019}, eissn = {1531-4995}, pages = {E255-E262}, orcid-numbers = {Endrész, Valéria/0000-0002-9402-3857; Igaz, Nóra/0000-0003-1580-4397; Spengler, Gabriella/0000-0001-8085-0950; Tiszlavicz, László/0000-0003-1134-6587; Burián, Katalin/0000-0003-1300-2374; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Rovó, László/0000-0003-1782-1756} } @CONFERENCE{MTMT:32894008, title = {Copper(II) complexes of salicylaldehyde thiosemicarbazone and its sterane-based conjugate: solution stability, redox properties and cytotoxicity}, url = {https://m2.mtmt.hu/api/publication/32894008}, author = {Tatsiana, Petrasheuskaya and Orsolya, Dömötör and Spengler, Gabriella and Annamária, Kincses and Kiss, Márton Attila and Nagyné Frank, Éva and Éva, A. Enyedy}, booktitle = {ISMEC 2019 International Symposium on Metal Complexes BOOK OF ABSTRACTS}, unique-id = {32894008}, year = {2019}, pages = {161}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Nagyné Frank, Éva/0000-0002-1332-0551} } @article{MTMT:30409869, title = {Pharmacophoric features for a very potent 5-spirofluorenehydantoin inhibitor of cancer efflux pump ABCB1, based on X-ray analysis}, url = {https://m2.mtmt.hu/api/publication/30409869}, author = {Żesławska, Ewa and Kincses, Annamária and Spengler, Gabriella and Nitek, Wojciech and Tejchman, Waldemar and Handzlik, Jadwiga}, doi = {10.1111/cbdd.13473}, journal-iso = {CHEM BIOL DRUG DES}, journal = {CHEMICAL BIOLOGY & DRUG DESIGN}, volume = {93}, unique-id = {30409869}, issn = {1747-0277}, abstract = {In order to extend knowledge about pharmacophoric features responsible for ABCB1 inhibitory properties of imidazolidin-2,4-dione derivatives, 1'-[4-(4-(o-methoxyphenyl)-piperazin-1-yl)butyl]-3'-methyl-spiro(fluoren-9,5'-imidazolidine)-2',4'-dione (3) and its salt (4) with rhodanine-3-acetic acid (RA) were prepared and investigated by X-ray diffraction method, as well as their efflux modulating effects in cancer cells (mouse T-lymphoma), cytotoxic and antiproliferative activities were evaluated in vitro. The molecular geometry, intermolecular interactions and crystal packing of base and acid forms of 3 were analyzed to see, if conformational changes influence the biological activities. The geometry of 2-methoxyphenylpiperazine and 5-spirofluorenehydantoin moieties was compared with other crystal structures containing these fragments. Our results indicated a very potent inhibitory action on ABCB1 pump, and significant cytotoxic and antiproliferative properties of 3 in T-lymphoma, even more potent in the case of MDR cells. Furthermore, the compound 3 converted into the salt 4 of inactive acid (RA) has maintained both, the efflux pump inhibitory and antiproliferative activities, showing strong synergism with doxorubicin. A comparison of geometry of 3 in both crystal structures (3 and 4) shows a significant difference in the arrangement of piperazine ring with respect to the aliphatic linker. This article is protected by copyright. All rights reserved.}, keywords = {crystal structure; arylpiperazine derivative of hydantoin; efflux pump inhibitor; pharmacophor; rhodanine-3-acetic acid}, year = {2019}, eissn = {1747-0285}, pages = {844-853}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3389574, title = {Antibacterial and Resistance Modifying Activities of Nigella sativa Essential Oil and its Active Compounds Against Listeria monocytogenes}, url = {https://m2.mtmt.hu/api/publication/3389574}, author = {Ahmad, Mouwakeh and Telbisz, Ágnes Mária and Spengler, Gabriella and Mohácsiné Farkas, Csilla and Kiskó, Gabriella}, doi = {10.21873/invivo.11302}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {32}, unique-id = {3389574}, issn = {0258-851X}, year = {2018}, eissn = {1791-7549}, pages = {737-743}, orcid-numbers = {Telbisz, Ágnes Mária/0000-0003-0972-4606; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:3375678, title = {Evaluation of antibiotic susceptibility of urinary tract pathogens depending on the pH}, url = {https://m2.mtmt.hu/api/publication/3375678}, author = {Kincses, Annamária and Orsolya, Vásárhelyi and Nové, Márta and Klaudia, Vincze and Zsoldiné Urbán, Edit and Spengler, Gabriella}, booktitle = {28th European Congress of Clinical Microbiology and Infectious Diseases (28th ECCMID)}, unique-id = {3375678}, year = {2018}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:30424629, title = {THE ROLE OF PH REGARDING ANTIBIOTIC SUSCEPTIBILITY OF URINARY TRACT PATHOGENS}, url = {https://m2.mtmt.hu/api/publication/30424629}, author = {Kincses, Annamária and ORSOLYA, VÁSÁRHELYI and Nové, Márta and Zsoldiné Urbán, Edit and Spengler, Gabriella}, booktitle = {A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium}, unique-id = {30424629}, year = {2018}, pages = {31}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3393151, title = {In Vitro Evaluation of the Multidrug Resistance Reversing Activity of Novel Imidazo[4,5-b]pyridine Derivatives.}, url = {https://m2.mtmt.hu/api/publication/3393151}, author = {Bourichi, S and Misbahi, H and Rodi, YK and Chahdi, FO and Essassi, EM and Szabo, S and Szalontai, B and Gajdács, Márió and Molnár, József and Spengler, Gabriella}, doi = {10.21873/anticanres.12687}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {38}, unique-id = {3393151}, issn = {0250-7005}, abstract = {BACKGROUND/AIM: Malignant diseases present a significant public health burden worldwide and their treatment is further complicated by the phenomenon of multidrug resistance. Derivatives of imidazopyridine exhibit several remarkable pharmacological activities and they could reverse the multidrug resistance of cancer cells due to overexpressing P-glycoprotein. MATERIALS AND METHODS: A series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their biological activities were evaluated in vitro using parental (PAR) and multidrug resistant (MDR; ABCB1-overexpressing) mouse T-lymphoma cells. The cytotoxic activity and selectivity of the tested compounds were assessed by the thiazolyl blue tetrazolium bromide (MTT) assay, the ABCB1 modulating activity was measured by rhodamine 123 accumulation assay using flow cytometry. RESULTS: Six compounds (b, c, d, f, h and i) showed moderate-to-high cytotoxic activity on the tested cell lines, while derivative i presented with promising selectivity towards the MDR cell line. Derivatives a, d, f, g and i were proven to be effective modulators of the ABCB1 multidrug efflux pump, with two compounds showing efflux pump modulatory activity at 2 muM concentration. CONCLUSION: Based on our experimental results, compounds that showed potent activity are those with a short carbon side chain; a methoxy group on the benzene ring; a heterocyclic (triazole) side chain and the presence of an alkylated N-atom at position 4.}, year = {2018}, eissn = {1791-7530}, pages = {3999-4003}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30434556, title = {A szexuális úton átvihető, szisztémás megbetegedést okozó mikroorganizmusok ismerete középiskolai pedagógusok számára 2. rész Knowledge of the sexually transmitted microorganisms causing systemic diseases for high school teachers}, url = {https://m2.mtmt.hu/api/publication/30434556}, author = {Burián, Katalin and Spengler, Gabriella and Mosolygó, Tímea}, doi = {10.24365/ef.v59i6.353}, journal-iso = {EGÉSZSÉGFEJLESZTÉS}, journal = {EGÉSZSÉGFEJLESZTÉS}, volume = {59}, unique-id = {30434556}, issn = {1786-2434}, year = {2018}, eissn = {2498-6666}, pages = {14-20}, orcid-numbers = {Burián, Katalin/0000-0003-1300-2374; Spengler, Gabriella/0000-0001-8085-0950; Mosolygó, Tímea/0000-0002-4499-388X} } @article{MTMT:30378624, title = {Terpenoids from Euphorbia pedroi as Multidrug-Resistance Reversers}, url = {https://m2.mtmt.hu/api/publication/30378624}, author = {Ferreira, Ricardo J. and Kincses, Annamária and Gajdács, Márió and Spengler, Gabriella and dos, Santos Daniel J. V. A. and Molnár, József and Ferreira, Maria-Jose U.}, doi = {10.1021/acs.jnatprod.8b00326}, journal-iso = {J NAT PROD}, journal = {JOURNAL OF NATURAL PRODUCTS}, volume = {81}, unique-id = {30378624}, issn = {0163-3864}, year = {2018}, eissn = {1520-6025}, pages = {2032-2040}, orcid-numbers = {Ferreira, Ricardo J./0000-0003-2590-8229; Kincses, Annamária/0000-0002-1591-1419; Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:3375888, title = {Hydrazone-based transition metal complexes as novel antiviral agents and antibiotic adjuvants: an in vitro study}, url = {https://m2.mtmt.hu/api/publication/3375888}, author = {Spengler, Gabriella and Gajdács, Márió and Kincses, Annamária and Nové, Márta and Berta, Barta Holló and Mosolygó, Tímea and Burián, Katalin and Katalin, Mészáros Szécsényi}, booktitle = {28th European Congress of Clinical Microbiology and Infectious Diseases (28th ECCMID)}, unique-id = {3375888}, year = {2018}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Gajdács, Márió/0000-0003-1270-0365; Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:3399647, title = {Rákellenes és efflux pumpa gátló hatású szelénvegyületek ADME tulajdonságainak becslése számítógépes módszerrel [Prediction of ADME properties for selenocompounds with anticancer and efflux pump inhibitory activity using preliminary computational methods]}, url = {https://m2.mtmt.hu/api/publication/3399647}, author = {Gajdács, Márió and Jadwiga, Handzlik and Carmen, Sanmartín and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {88}, unique-id = {3399647}, issn = {0001-6659}, year = {2018}, eissn = {1587-1495}, pages = {67-73}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3399645, title = {Szerves szelénvegyületek mint daganatellenes szerek: kísérleti eredmények in vitro vastagbél adenokarcinóma modellen [Organoselenium compounds as antitumor agents: In vitro evaluation on a colon cancer model system]}, url = {https://m2.mtmt.hu/api/publication/3399645}, author = {Gajdács, Márió and Jadwiga, Handzlik and Carmen, Sanmartín and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {88}, unique-id = {3399645}, issn = {0001-6659}, year = {2018}, eissn = {1587-1495}, pages = {59-65}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:3376303, title = {Antitumor activity of organoselenium compounds against specific tumor types with significant mortality in Hungary}, url = {https://m2.mtmt.hu/api/publication/3376303}, author = {Gajdács, Márió and Domínguez-Álvarez, Enrique and Spengler, Gabriella}, booktitle = {Tavaszi Szél 2018 Konferencia. Nemzetközi Multidiszciplináris Konferencia}, unique-id = {3376303}, year = {2018}, pages = {389-389}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:3376302, title = {Schiff-bázis típusú ligandokkal rendelkező átmenetifém-komplexek daganatellenes hatásának vizsgálata}, url = {https://m2.mtmt.hu/api/publication/3376302}, author = {Gajdács, Márió and Kincses, Annamária and Nové, Márta and Unger, Vivien and Tóth, Viktor and Barta, Holló Berta and Magyari, József and Molnár, József and Mészáros, Szécsényi Katalin and Spengler, Gabriella}, booktitle = {Tavaszi Szél 2018 Konferencia. Nemzetközi Multidiszciplináris Konferencia}, unique-id = {3376302}, year = {2018}, pages = {388-388}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:3396274, title = {Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia}, url = {https://m2.mtmt.hu/api/publication/3396274}, author = {Mottaghipisheh, Javad and Spengler, Gabriella and Nové, Márta and Kúsz, Norbert and Hohmann, Judit and Csupor, Dezső}, booktitle = {Young Scientists' Meeting on Advances in Phytochemical Analysis}, unique-id = {3396274}, year = {2018}, orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189; Spengler, Gabriella/0000-0001-8085-0950; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:3368729, title = {Interactions of Schiff base compounds and their coordination complexes with the drug cisplatin}, url = {https://m2.mtmt.hu/api/publication/3368729}, author = {József, Magyari and Berta, Barta Holló and Ljiljana, S Vojinović-Ješić and Mirjana, M Radanović and Stevan, Armaković and Sanja, J Armaković and Molnár, József and Kincses, Annamária and Gajdács, Márió and Spengler, Gabriella and Katalin, Mészáros Szécsényi}, doi = {10.1039/c8nj00357b}, journal-iso = {NEW J CHEM}, journal = {NEW JOURNAL OF CHEMISTRY}, volume = {42}, unique-id = {3368729}, issn = {1144-0546}, year = {2018}, eissn = {1369-9261}, pages = {5834-5843}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3340031, title = {Bioactive compounds from the African medicinal plant Cleistochlamys kirkii as resistance modifiers in bacteria}, url = {https://m2.mtmt.hu/api/publication/3340031}, author = {Kincses, Annamária and Varga, Borisz and Csonka, Ákos and Sancha, S and Mulhovo, S and Madureira, AM and Ferreira, MU and Spengler, Gabriella}, doi = {10.1002/ptr.6042}, journal-iso = {PHYTOTHER RES}, journal = {PHYTOTHERAPY RESEARCH}, volume = {32}, unique-id = {3340031}, issn = {0951-418X}, abstract = {Cleistochlamys kirkii (Benth) Oliv. (Annonaceae) is a medicinal plant traditionally used in Mozambique to treat infectious diseases. The aim of this study was to find resistance modifiers in C. kirkii for Gram-positive and Gram-negative model bacterial strains. One of the most important resistance mechanisms in bacteria is the efflux pump-related multidrug resistance. Therefore, polycarpol (1), three C-benzylated flavanones (2-4), and acetylmelodorinol (5) were evaluated for their multidrug resistance-reverting activity on methicillin-susceptible and methicillin-resistant Staphylococcus aureus and Escherichia coli AG100 and AG100 A strains overexpressing and lacking the AcrAB-TolC efflux pump system. The combined effects of antibiotics and compounds (2 and 4) were also assessed by using the checkerboard microdilution method in both S. aureus strains. The relative gene expression of the efflux pump genes was determined by real-time reverse transcriptase quantitative polymerase chain reaction. The inhibition of quorum sensing was also investigated. The combined effect of the antibiotics and compound 2 or 4 on the methicillin-sensitive S. aureus resulted in synergism. The most active compounds 2 and 4 increased the expression of the efflux pump genes. These results suggested that C. kirkii constituents could be effective adjuvants in the antibiotic treatment of infections.}, year = {2018}, eissn = {1099-1573}, pages = {1039-1046}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:3426792, title = {Semi-synthetic preparation of antitumor p-coumaric acid derivatives}, url = {https://m2.mtmt.hu/api/publication/3426792}, author = {Fási, Laura and Gyovai, András and Zupkó, István and Nové, Márta and Spengler, Gabriella and Fang-Rong, Chang and Hunyadi, Attila}, booktitle = {GA2018: The 66th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA); S-TCM 2018 : The 11th Shanghai International Conference on Traditional Chinese Medicine and Natural Medicine}, unique-id = {3426792}, year = {2018}, orcid-numbers = {Gyovai, András/0000-0003-2316-2160; Zupkó, István/0000-0003-3243-5300; Spengler, Gabriella/0000-0001-8085-0950; Hunyadi, Attila/0000-0003-0074-3472} } @CONFERENCE{MTMT:30424623, title = {Pharmaceutical Compounds as Quorum Sensing (QS) Inhibitors}, url = {https://m2.mtmt.hu/api/publication/30424623}, author = {Gajdács, Márió and Szegedi, Ernő and Molnár, József and Spengler, Gabriella}, booktitle = {A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium}, unique-id = {30424623}, year = {2018}, pages = {19-19}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:30424613, title = {Quorum Sensing Inhibition by Sulfur and Selenium-Containing Organochalcogens: A Comparative In Vitro Study}, url = {https://m2.mtmt.hu/api/publication/30424613}, author = {Gajdács, Márió and Dorota, Łażewska and Katarzyna, Kieć-Kononowicz and Carmen, Sanmartín and Jadwiga, Handzlik and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, booktitle = {A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium}, unique-id = {30424613}, year = {2018}, pages = {18-19}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:30424635, title = {ANTIBACTERIAL EFFECT OF DIAZINE-RING CONTAINING HYDRAZONES AND THEIR METAL COMPLEXES}, url = {https://m2.mtmt.hu/api/publication/30424635}, author = {Nové, Márta and Kincses, Annamária and Mosolygó, Tímea and AYMAN, EL-FAROUKI and Magyari, József and BERTA, HOLLÓ BARTA and Burián, Katalin and KATALIN, SZÉCSÉNYI MÉSZÁROS and Spengler, Gabriella}, booktitle = {A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium}, unique-id = {30424635}, year = {2018}, pages = {47}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Burián, Katalin/0000-0003-1300-2374; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:30426802, title = {Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia}, url = {https://m2.mtmt.hu/api/publication/30426802}, author = {Mottaghipisheh, Javad and Nové, Márta and Spengler, Gabriella and Kúsz, Norbert and Hohmann, Judit and Csupor, Dezső}, doi = {10.1080/13880209.2018.1548625}, journal-iso = {PHARM BIOL}, journal = {PHARMACEUTICAL BIOLOGY}, volume = {56}, unique-id = {30426802}, issn = {1388-0209}, year = {2018}, eissn = {1744-5116}, pages = {658-664}, orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189; Spengler, Gabriella/0000-0001-8085-0950; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333} } @CONFERENCE{MTMT:30344882, title = {Antiproliferative and cytotoxic activities of furocoumarins of Ducrosia anethifolia}, url = {https://m2.mtmt.hu/api/publication/30344882}, author = {Mottaghipisheh, Javad and Nové, Márta and Spengler, Gabriella and Kúsz, Norbert and Hohmann, Judit and Csupor, Dezső}, booktitle = {Fiatal Gyógynövénykutatók Fóruma: A Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztályának tudományos konferenciája}, doi = {10.14232/fgykf.2018.b1}, unique-id = {30344882}, year = {2018}, pages = {10-10}, orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189; Spengler, Gabriella/0000-0001-8085-0950; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333} } @CONFERENCE{MTMT:3375914, title = {Antimicrobial activity and mode of action of Nigella sativa against L. monocytogenes}, url = {https://m2.mtmt.hu/api/publication/3375914}, author = {Ahmad, MOUWAKEH and Telbisz, A and Spengler, Gabriella and Mohácsiné Farkas, Csilla and Kiskó, Gabriella}, booktitle = {Book of Abstracts}, unique-id = {3375914}, year = {2018}, pages = {94-95}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:30811859, title = {The antimicrobial and resistance modifying activities of Nigella sativa oil}, url = {https://m2.mtmt.hu/api/publication/30811859}, author = {Mouwakeh, A. and Kincses, Annamária and Nové, Márta and Mosolygó, Tímea and Spengler, Gabriella and Telbisz, Á. and Mohácsiné Farkas, Csilla and Kiskó, Gabriella}, booktitle = {Third International Conference on Food Science and Technology}, unique-id = {30811859}, year = {2018}, pages = {66}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3415888, title = {Synthesis and characterization of Sr and Mg-doped hydroxyapatite by a simple precipitation method}, url = {https://m2.mtmt.hu/api/publication/3415888}, author = {Nagyné Kovács, Teodóra and Studnicka, L and Kincses, Annamária and Spengler, Gabriella and Molnár, Mónika and Tolner, Mária and Lukács, István Endre and Szilágyi, Imre Miklós and Pokol, György}, doi = {10.1016/j.ceramint.2018.09.096}, journal-iso = {CERAM INT}, journal = {CERAMICS INTERNATIONAL}, volume = {44}, unique-id = {3415888}, issn = {0272-8842}, year = {2018}, eissn = {1873-3956}, pages = {22976-22982}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Molnár, Mónika/0000-0001-5296-7924; Lukács, István Endre/0000-0002-4985-4475; Pokol, György/0000-0003-1597-9808} } @article{MTMT:3311971, title = {Comparative solution equilibrium and structural studies of half-sandwich ruthenium(II)(η6-toluene) complexes of picolinate derivatives}, url = {https://m2.mtmt.hu/api/publication/3311971}, author = {Poljarević, Jelena M and Gál, Gyula Tamás and May, Nóra Veronika and Spengler, Gabriella and Dömötör, Orsolya and Savić, Aleksandar R and Grgurić-Šipka, Sanja and Enyedy, Éva Anna}, doi = {10.1016/j.jinorgbio.2017.12.017}, journal-iso = {J INORG BIOCHEM}, journal = {JOURNAL OF INORGANIC BIOCHEMISTRY}, volume = {181}, unique-id = {3311971}, issn = {0162-0134}, year = {2018}, eissn = {1873-3344}, pages = {74-85}, orcid-numbers = {May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Dömötör, Orsolya/0000-0001-8736-3215; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:3351673, title = {Bioactive Segetane, Ingenane, and Jatrophane Diterpenes from Euphorbia taurinensis}, url = {https://m2.mtmt.hu/api/publication/3351673}, author = {Rédei, Dóra and Kúsz, Norbert and Sátori, Gréta and Kincses, Annamária and Spengler, Gabriella and Burián, Katalin and Barina, Zoltán and Hohmann, Judit}, doi = {10.1055/a-0589-0525}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {84}, unique-id = {3351673}, issn = {0032-0943}, year = {2018}, eissn = {1439-0221}, pages = {729-735}, orcid-numbers = {Rédei, Dóra/0000-0002-5013-247X; Kúsz, Norbert/0000-0002-9973-6442; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Burián, Katalin/0000-0003-1300-2374; Barina, Zoltán/0000-0003-3117-7186; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:30378623, title = {Benzoxazole-based Zn(II) and Cu(II) Complexes Overcome Multidrug-resistance in Cancer}, url = {https://m2.mtmt.hu/api/publication/30378623}, author = {Spengler, Gabriella and Kincses, Annamária and Rácz, Bálint and Varga, Borisz and Watanabe, Genki and Saijo, Ryosuke and Sekiya, Hiroshi and Tamai, Eiji and Maki, Jun and Molnár, József and Kawase, Masami}, doi = {10.21873/anticanres.12971}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {38}, unique-id = {30378623}, issn = {0250-7005}, year = {2018}, eissn = {1791-7530}, pages = {6181-6187}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419; Rácz, Bálint/0000-0003-0088-3408} } @article{MTMT:31402136, title = {Mitomycin-C fibrosisgátló hatása humán primer hangszalag-fibrolastokon - felső légúti hegesedések kezelésének új lehetősége}, url = {https://m2.mtmt.hu/api/publication/31402136}, author = {Szabó, Diána and Kovács, Dávid and Endrész, Valéria and Igaz, Nóra and Spengler, Gabriella and Csontné Kiricsi, Mónika and Tiszlavicz, László and Rovó, László}, journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, volume = {64}, unique-id = {31402136}, issn = {0016-237X}, year = {2018}, pages = {110-110}, orcid-numbers = {Endrész, Valéria/0000-0002-9402-3857; Igaz, Nóra/0000-0003-1580-4397; Spengler, Gabriella/0000-0001-8085-0950; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Tiszlavicz, László/0000-0003-1134-6587; Rovó, László/0000-0003-1782-1756} } @article{MTMT:3411679, title = {Exocyclic Sulfur and Selenoorganic Compounds Towards Their Anticancer Effects: Crystallographic and Biological Studies}, url = {https://m2.mtmt.hu/api/publication/3411679}, author = {Zeslawska, E and Kincses, Annamária and Unger, V and Toth, V and Spengler, Gabriella and Nitek, W and Tejchman, W}, doi = {10.21873/anticanres.12762}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {38}, unique-id = {3411679}, issn = {0250-7005}, abstract = {BACKGROUND/AIM: Multidrug resistance leads to therapeutic difficulties. There is great interest in experimental chemotherapy regarding multidrug resistance inhibitors and new anticancer agents. The aim of this study was to evaluate the anticancer activity of exocyclic sulfur and selenoorganic compounds on mouse T-lymphoma cell lines. MATERIALS AND METHODS: A series of eighteen sulfur and selenium analogues of 2[1H]-pyrimidinone and hydantoin derivatives were evaluated towards their efflux modulating, cytotoxic and antiproliferative effects in mouse T-lymphoma cells. The combination assay with doxorubicin on multidrug resistant mouse T-lymphoma cells was performed in order to see the nature of drug interactions. Crystal structures were determined for two selected compounds with the highest efflux-modulating activity. RESULTS: The sulfur analogues with aromatic rings almost perpendicular to pyrimidinethione ring at positions 1 and 6 showed the highest efflux inhibitory action, while all selenium analogues showed good antiproliferative and cytotoxic activities. CONCLUSION: The sulfur analogues can be modified towards improving their efflux inhibitory activity, whereas the selenium towards antiproliferative and cytotoxic activities.}, keywords = {Animals; MICE; Cell Proliferation/drug effects; Cell Line, Tumor; Doxorubicin/pharmacology; Drug Resistance, Neoplasm/drug effects; Drug Resistance, Multiple/drug effects; Antineoplastic Agents/*chemistry/*pharmacology; Lymphoma, T-Cell/*drug therapy; Sulfur/*chemistry/*pharmacology; Selenium/*chemistry/*pharmacology; Cytotoxins/chemistry/pharmacology}, year = {2018}, eissn = {1791-7530}, pages = {4577-4584}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3283956, title = {SELENOCOMPOUNDS AS PROMISING ANTIBACTRIAL AGENTS}, url = {https://m2.mtmt.hu/api/publication/3283956}, author = {Csonka, Andrea and Kincses, Annamária and Mosolygó, Tímea and Ádám, Szabó Tönki and Carmen, Sanmartín and Jadwiga, Handzlik and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3283956}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {118-119}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3284060, title = {Anticancer activity of diterpenes isolated from euphorbia taurinensis}, url = {https://m2.mtmt.hu/api/publication/3284060}, author = {Kincses, Annamária and Sátori, Gréta and Kúsz, Norbert and Mosolygó, Tímea and Burián, Katalin and Hohmann, Judit and Rédei, Dóra and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3284060}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {135-136}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Kúsz, Norbert/0000-0002-9973-6442; Mosolygó, Tímea/0000-0002-4499-388X; Burián, Katalin/0000-0003-1300-2374; Hohmann, Judit/0000-0002-2887-6392; Rédei, Dóra/0000-0002-5013-247X; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3284046, title = {CONSTITUENTS OF CLEISTOCHLAMYS KIRKII AS ANTIBACTERIALS AND EFFLUX PUMP INHIBITORS}, url = {https://m2.mtmt.hu/api/publication/3284046}, author = {Kincses, Annamária and Spengler, Gabriella and Szilvia, Varga and Varga, Borisz and Csonka, Ákos and Shirley, Sancha and Silva, Mulhovo and Ana, Margarida Madureira and Maria-José, U Ferreira}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3284046}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {134-135}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3283415, title = {Fluorinated Phosphorus Ylides as Inhibitors of Bacterial Efflux Pumps}, url = {https://m2.mtmt.hu/api/publication/3283415}, author = {Kincses, Annamária and Szabó, Ágnes Míra and Ryosuke, Saijo and Genki, Watanabe and Masami, Kawase and Molnár, József and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3283415}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {43}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:3228067, title = {Selenocompounds as novel antibacterial agents and efflux pump inhibitors in Gram-negative bacteria}, url = {https://m2.mtmt.hu/api/publication/3228067}, author = {Kincses, Annamária and Spengler, Gabriella and Mosolygó, Tímea and Ádám, Szabó-Tönki and Carmen, Sanmartin and Jadwiga, Handzlik and Enrique, Dominguez-Álvarez}, unique-id = {3228067}, year = {2017}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Mosolygó, Tímea/0000-0002-4499-388X} } @article{MTMT:3283951, title = {Antibacterial Activity of Hydrazone-Based Transition Metal Complexes}, url = {https://m2.mtmt.hu/api/publication/3283951}, author = {Berta, Barta Holló and József, Magyari and Kincses, Annamária and Gajdács, Márió and Nové, Márta and Varga, Borisz and Csonka, Ákos and Spengler, Gabriella and Katalin, Mészáros Szécsényi}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3283951}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {112-112}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3271829, title = {Possible Biological and Clinical Applications of Phenothiazines}, url = {https://m2.mtmt.hu/api/publication/3271829}, author = {Varga, Borisz and Csonka, Ákos and Csonka, Andrea and Molnár, József and Leonard, Amaral and Spengler, Gabriella}, doi = {10.21873/anticanres.12045}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {37}, unique-id = {3271829}, issn = {0250-7005}, keywords = {Animals; Humans; Antineoplastic Agents/*pharmacology; Infection/drug therapy; Neoplasms/drug therapy; Anti-Infective Agents/*pharmacology; Phenothiazines/*pharmacology; Antipsychotic Agents/*pharmacology; Mental Disorders/drug therapy}, year = {2017}, eissn = {1791-7530}, pages = {5983-5993}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3280072, title = {A leggyakoribb nemi betegségekre vonatkozó ismeretek középiskolai pedagógusok számára I. rész. Knowledge of the most common genital diseases for high school teachers Part I}, url = {https://m2.mtmt.hu/api/publication/3280072}, author = {Burián, Katalin and Spengler, Gabriella}, doi = {10.24365/ef.v58i3.175}, journal-iso = {EGÉSZSÉGFEJLESZTÉS}, journal = {EGÉSZSÉGFEJLESZTÉS}, volume = {58}, unique-id = {3280072}, issn = {1786-2434}, year = {2017}, eissn = {2498-6666}, pages = {18-25}, orcid-numbers = {Burián, Katalin/0000-0003-1300-2374; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:3212796, title = {Metallic nanoparticles in the tumor microenvironment disrupt tumor-stroma crosstalk and inhibit metastasis}, url = {https://m2.mtmt.hu/api/publication/3212796}, author = {Kovács, Dávid and Igaz, Nóra and Annamária, Marton and Bélteky, Péter and Spengler, Gabriella and Csaba, Vizler and Bodai, László and Boros, Imre Miklós and Zoltán, Kónya and Csontné Kiricsi, Mónika}, booktitle = {Hungarian Molecular Life Sciences 2017}, unique-id = {3212796}, year = {2017}, pages = {219-220}, orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Spengler, Gabriella/0000-0001-8085-0950; Bodai, László/0000-0001-8411-626X; Boros, Imre Miklós/0000-0001-8504-9687; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @misc{MTMT:3341246, title = {4th Congress of European ORL- HNS. Antifibrotic effect of Mitomycin-C human vocal cord fibroblast - impact on upper airway stenosis treatment}, url = {https://m2.mtmt.hu/api/publication/3341246}, author = {Szabó, Diána and Endrész, Valéria and Dávid, Kovács and Igaz, Nóra and Spengler, Gabriella and Molnár, József and Burián, Katalin and Csontné Kiricsi, Mónika and Rovó, László}, unique-id = {3341246}, year = {2017}, pages = {110-110}, orcid-numbers = {Endrész, Valéria/0000-0002-9402-3857; Igaz, Nóra/0000-0003-1580-4397; Spengler, Gabriella/0000-0001-8085-0950; Burián, Katalin/0000-0003-1300-2374; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Rovó, László/0000-0003-1782-1756} } @article{MTMT:3289256, title = {Identification and antimicrobial susceptibility testing of anaerobic bacteria: Rubik's cube of clinical microbiology?}, url = {https://m2.mtmt.hu/api/publication/3289256}, author = {Gajdács, Márió and Spengler, Gabriella and Zsoldiné Urbán, Edit}, doi = {10.3390/antibiotics6040025}, journal-iso = {ANTIBIOTICS-BASEL}, journal = {ANTIBIOTICS}, volume = {6}, unique-id = {3289256}, abstract = {Anaerobic bacteria have pivotal roles in the microbiota of humans and they are significant infectious agents involved in many pathological processes, both in immunocompetent and immunocompromised individuals. Their isolation, cultivation and correct identification differs significantly from the workup of aerobic species, although the use of new technologies (e.g., matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, whole genome sequencing) changed anaerobic diagnostics dramatically. In the past, antimicrobial susceptibility of these microorganisms showed predictable patterns and empirical therapy could be safely administered but recently a steady and clear increase in the resistance for several important drugs (beta-lactams, clindamycin) has been observed worldwide. For this reason, antimicrobial susceptibility testing of anaerobic isolates for surveillance purposes or otherwise is of paramount importance but the availability of these testing methods is usually limited. In this present review, our aim was to give an overview of the methods currently available for the identification (using phenotypic characteristics, biochemical testing, gas-liquid chromatography, MALDI-TOF MS and WGS) and antimicrobial susceptibility testing (agar dilution, broth microdilution, disk diffusion, gradient tests, automated systems, phenotypic and molecular resistance detection techniques) of anaerobes, when should these methods be used and what are the recent developments in resistance patterns of anaerobic bacteria.}, year = {2017}, eissn = {2079-6382}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950; Zsoldiné Urbán, Edit/0000-0002-9602-7552} } @article{MTMT:3179770, title = {Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line}, url = {https://m2.mtmt.hu/api/publication/3179770}, author = {Gajdács, Márió and Spengler, Gabriella and Sanmartin, C and Marc, MA and Handzlik, J and Dominguez-Alvarez, E}, doi = {10.1016/j.bmcl.2017.01.033}, journal-iso = {BIOORG MED CHEM LETT}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, volume = {27}, unique-id = {3179770}, issn = {0960-894X}, abstract = {Taking into account that multidrug resistance (MDR) is the main cause for chemotherapeutic failure in cancer treatment and as a continuation of our efforts to overcome this problem we report the evaluation of one cyclic selenoanhydride (1) and ten selenoesters (2-11) in MDR human colon adenocarcinoma Colo 320 cell line. The most potent derivatives (1, 9-11) inhibited the ABCB1 efflux pump much stronger than the reference compound verapamil. Particularly, the best one (9) was 4-fold more potent than verapamil at a 10-fold lower concentration. Furthermore, the evaluated derivatives exerted a potent and selective cytotoxic activity. In addition, they were strong apoptosis inducers as the four derivatives triggered apoptotic events in a 64-72% of the examined MDR Colo 320 human adenocarcinoma cells.}, year = {2017}, eissn = {1464-3405}, pages = {797-802}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:3285973, title = {Rákellenes hatású szelenoészterek a kombinációs kemoterápiában}, url = {https://m2.mtmt.hu/api/publication/3285973}, author = {Gajdács, Márió and Handzlik, Jadwiga and Sanmartín, Carmen and Domínguez-Álvarez, Enrique and Spengler, Gabriella}, booktitle = {DKK17-Doktoranduszok a Klinikai Kutatásokban absztraktkötet}, unique-id = {3285973}, year = {2017}, pages = {45-45}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:3237695, title = {Selenocompounds as combinational agents in cancer chemotherapy: An in vitro perspective}, url = {https://m2.mtmt.hu/api/publication/3237695}, author = {Gajdács, Márió and Jadwiga, Handzlik and Carmen, Sanmartín and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, booktitle = {19th DKMT Euroregional Conference on Environment and Health}, unique-id = {3237695}, year = {2017}, pages = {40-40}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:3207896, title = {Szelenoanhidrid és szelenoészter típusú vegyületek multidrog rezisztencia visszafordító hatása vastagbél adenokarcinóma sejteken}, url = {https://m2.mtmt.hu/api/publication/3207896}, author = {Gajdács, Márió and Domínguez-Álvarez, Enrique and Handzlik, Jadwiga and Spengler, Gabriella}, booktitle = {Tavaszi Szél 2017 Konferencia. Nemzetközi Multidiszciplináris Konferencia}, unique-id = {3207896}, year = {2017}, pages = {365-366}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:3239469, title = {Synthesis, solution equilibria and antitumor activity of Ru(II)(η6-toluene) complexes of various picolinates}, url = {https://m2.mtmt.hu/api/publication/3239469}, author = {Jelena, M. Poljarevic and May, Nóra Veronika and Spengler, Gabriella and Dömötör, Orsolya and Milica, Orlovic and Aleksandar, R. Savic and Sanja, Grguric-Sipka and Éva, A. Enyedy}, booktitle = {14th International Conference on Applied Bioinorganic Chemistry}, unique-id = {3239469}, year = {2017}, pages = {245-245}, orcid-numbers = {May, Nóra Veronika/0000-0003-4770-4681; Spengler, Gabriella/0000-0001-8085-0950; Dömötör, Orsolya/0000-0001-8736-3215} } @{MTMT:3287447, title = {Szelénvegyületek biológiai hatásának vizsgálata baktérium modelleken}, url = {https://m2.mtmt.hu/api/publication/3287447}, author = {Kincses, Annamária and Spengler, Gabriella and Szabó, Tönki Ádám and Domínguez-Álvarez, Enrique}, booktitle = {DKK17-Doktoranduszok a Klinikai Kutatásokban absztraktkötet}, unique-id = {3287447}, year = {2017}, pages = {61-61}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3287853, title = {Novel MDR-modulating Diterpenes from Euphorbia taurinensis}, url = {https://m2.mtmt.hu/api/publication/3287853}, author = {Kúsz, Norbert and Sátori, Gréta and Kincses, Annamária and Spengler, Gabriella and Barina, Zoltán and Hohmann, Judit and Rédei, Dóra}, doi = {10.1055/s-0037-1608146}, journal-iso = {PLANTA MEDICA INT OPEN}, journal = {PLANTA MEDICA INTERNATIONAL OPEN}, volume = {4}, unique-id = {3287853}, year = {2017}, eissn = {2509-6656}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Barina, Zoltán/0000-0003-3117-7186; Hohmann, Judit/0000-0002-2887-6392; Rédei, Dóra/0000-0002-5013-247X} } @article{MTMT:3284004, title = {Selenoester Derivatives as Novel Antifungal and Antiviral Agents}, url = {https://m2.mtmt.hu/api/publication/3284004}, author = {Gajdács, Márió and Mosolygó, Tímea and Zsoldiné Urbán, Edit and Carmen, Sanmartín and Jadwiga, Handzlik and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3284004}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {122-123}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Mosolygó, Tímea/0000-0002-4499-388X; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Spengler, Gabriella/0000-0001-8085-0950} } @inproceedings{MTMT:3280164, title = {In vitro and in silico assessment of urea/thiourea derivatives in antimicrobial therapy}, url = {https://m2.mtmt.hu/api/publication/3280164}, author = {Gajdács, Márió and Mosolygó, Tímea and Zsoldiné Urbán, Edit and Dorota, Łażewska and Jadwiga, Handzlik and Katarzyna, Kieć-Kononowicz and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, booktitle = {XL Kémiai Előadói Napok}, unique-id = {3280164}, year = {2017}, pages = {116-118}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Mosolygó, Tímea/0000-0002-4499-388X; Zsoldiné Urbán, Edit/0000-0002-9602-7552; Spengler, Gabriella/0000-0001-8085-0950} } @inproceedings{MTMT:3280162, title = {Evaluation of urea/thiourea derivatives as adjuvants in cancer chemotherapy}, url = {https://m2.mtmt.hu/api/publication/3280162}, author = {Gajdács, Márió and Zsanett, Szabó and Dorota, Łażewska and Jadwiga, Handzlik and Katarzyna, Kieć-Kononowicz and Enrique, Domínguez-Álvarez and Spengler, Gabriella}, booktitle = {XL Kémiai Előadói Napok}, unique-id = {3280162}, year = {2017}, pages = {113-115}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:3215185, title = {The attitude of healthcare professionals towards antibiotic resistance}, url = {https://m2.mtmt.hu/api/publication/3215185}, author = {Gajdács, Márió and Spengler, Gabriella and Markó-Kucsera, Mária and Szabó, Andrea and Paulik, Edit}, booktitle = {27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)}, unique-id = {3215185}, year = {2017}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950; Paulik, Edit/0000-0002-3446-4327} } @article{MTMT:3284117, title = {THE ROLE OF EFFLUX PUMPS AND ENVIRONMENTAL pH IN BACTERIAL MULTIDRUG RESISTANCE}, url = {https://m2.mtmt.hu/api/publication/3284117}, author = {Nové, Márta and Kincses, Annamária and Orsolya, Vásárhelyi and Vivien, Unger and Viktor, Tóth and Molnár, József and Leonard, Amaral and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3284117}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {155-156}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3183602, title = {Dregamine and tabernaemontanine derivatives as ABCB1 modulators on resistant cancer cells}, url = {https://m2.mtmt.hu/api/publication/3183602}, author = {Paterna, A and Kincses, Annamária and Spengler, Gabriella and Mulhovo, S and Molnár, József and Ferreira, Maria-Jose U.}, doi = {10.1016/j.ejmech.2017.01.044}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {128}, unique-id = {3183602}, issn = {0223-5234}, abstract = {Dregamine (1) and tabernaemontanine (2), two epimeric monoterpene indole alkaloids isolated in large amount from the roots of the African plant Tabernaemontana elegans, were derivatized, yielding ten imine derivatives, as previously described (3-12). In the present study, aiming at increasing the pool of analogues for establishing structure-activity relationships (SAR), compounds 1 and 2 were further submitted to several chemical transformations, yielding thirteen new derivatives (13-25). Their structures were assigned by spectroscopic methods, including 1D and 2D NMR experiments. Compounds 1-25 were evaluated for their effects on the reversion of multidrug resistance (MDR) in cancer cells mediated by P-glycoprotein (P-gp/ABCB1), through combination of functional and chemosensitivity assays, using a human ABCB1-transfected mouse T-lymphoma cell model. SAR analysis showed that different substituents at C-3 and at the indole nitrogen led to different ABCB1 modulatory effects. When compared to the parent compounds, a remarkable enhancement in MDR reversal activity was found for derivatives sharing a new aromatic moiety. Thus, the strongest ability as MDR reversers, and a manifold activity when compared to verapamil, was found for compound 8, the epimeric compounds 9 and 10, and compound 15, bearing pyrazine, bromo-pyridine, and methoxybenzyloxycarbonyl moieties, respectively. In drug combination assays, all compounds tested were revealed to interact synergistically with doxorubicin. Collectively, the results indicate that some of these derivatives may be promising leads for overcoming MDR in cancer.}, year = {2017}, eissn = {1768-3254}, pages = {247-257}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3227556, title = {Exploring Jolkinol D Derivatives To Overcome Multidrug Resistance in Cancer}, url = {https://m2.mtmt.hu/api/publication/3227556}, author = {Reis, MA and Ahmed, OB and Spengler, Gabriella and Molnár, József and Lage, H and Ferreira, MU}, doi = {10.1021/acs.jnatprod.6b01084}, journal-iso = {J NAT PROD}, journal = {JOURNAL OF NATURAL PRODUCTS}, volume = {80}, unique-id = {3227556}, issn = {0163-3864}, abstract = {Macrocyclic monoacyl lathyrane derivatives bearing a benzoyl moiety were previously found to be strong ABCB1 modulators. To explore the effects of different substituents of the aromatic moiety, 14 new compounds (1.1-1.7, 1.10, and 2.1-2.4) were prepared from jolkinol D (1), obtained from Euphorbia piscatoria, and from jolkinodiol (2), its hydrolysis derivative. Compounds 1.8 and 1.9, having aliphatic moieties, were also obtained. The reversal of ABCB1-mediated MDR was evaluated through functional and chemosensitivity assays on the human ABCB1-gene-transfected L5178Y mouse T-lymphoma cell line. Structure-activity relationships showed that addition of electron-donating groups to the aromatic moiety improved the activity. The effects on the ATPase activity of the strongest modulator (1.3) and the inactive jolkinol D (1) were also investigated and compared. Moreover, in the chemosensitivity assay, most of the compounds interacted synergistically with doxorubicin. Compounds 1.1-1.10 and 2.1-2.4 were further assessed for their collateral sensitivity effect against the human cancer cells: EPG85-257 (gastric) and EPP85-181 (pancreatic), and the matching drug-selected cells EPG85-257RDB, EPG85-257RNOV, EPP85-181RDB, and EPP85-181RNOV. The most promising ones (1.8 and 1.10) along with compound 3, previously selected, were investigated as apoptosis inducers. The compounds were able to induce apoptosis through caspase-3 activation, with significant differences being observed between the parental and resistant cells.}, year = {2017}, eissn = {1520-6025}, pages = {1411-1420}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3201553, title = {New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria}, url = {https://m2.mtmt.hu/api/publication/3201553}, author = {Spengler, Gabriella and Kincses, Annamária and Gajdács, Márió and Amaral, L}, doi = {10.3390/molecules22030468}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {22}, unique-id = {3201553}, issn = {1420-3049}, abstract = {Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorrect use of antibiotics and other antimicrobials. This inappropriate application and mismanagement of antibiotics have led to serious problems in the therapy of infectious diseases. Bacteria can develop resistance by various mechanisms and one of the most important factors resulting in MDR is efflux pump-mediated resistance. Because of the importance of the efflux-related multidrug resistance the development of new therapeutic approaches aiming to inhibit bacterial efflux pumps is a promising way to combat bacteria having over-expressed MDR efflux systems. The definition of an efflux pump inhibitor (EPI) includes the ability to render the bacterium increasingly more sensitive to a given antibiotic or even reverse the multidrug resistant phenotype. In the recent years numerous EPIs have been developed, although so far their clinical application has not yet been achieved due to their in vivo toxicity and side effects. In this review, we aim to give a short overview of efflux mediated resistance in bacteria, EPI compounds of plant and synthetic origin, and the possible methods to investigate and screen EPI compounds in bacterial systems.}, year = {2017}, eissn = {1420-3049}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419; Gajdács, Márió/0000-0003-1270-0365} } @CONFERENCE{MTMT:3287590, title = {Synthesis and biological activity of oxidized chalcone derivatives}, url = {https://m2.mtmt.hu/api/publication/3287590}, author = {Gonda, Tímea and Spengler, Gabriella and Kincses, Annamária and Csorba, Attila and Kúsz, Norbert and Hunyadi, Attila}, booktitle = {COST ACTION CM1407 4th Meeting}, unique-id = {3287590}, year = {2017}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Kincses, Annamária/0000-0002-1591-1419; Csorba, Attila/0000-0002-4032-1605; Kúsz, Norbert/0000-0002-9973-6442; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:3284103, title = {Antibacterial effect of arylmethyl selenocyanates with various aromatic moieties}, url = {https://m2.mtmt.hu/api/publication/3284103}, author = {Mosolygó, Tímea and Yunsu, Jang and Muhammad, Jawad Nasim and Kincses, Annamária and Spengler, Gabriella and Burián, Katalin and Jadwiga, Handzlik and Claus, Jacob}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {64}, unique-id = {3284103}, issn = {1217-8950}, year = {2017}, eissn = {1588-2640}, pages = {148-149}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:3096947, title = {Structure-antiproliferative activity studies on L-proline- and homoproline-4-N-pyrrolidine-3-thiosemicarbazone hybrids and their nickel(II), palladium(II) and copper(II) complexes}, url = {https://m2.mtmt.hu/api/publication/3096947}, author = {Aliona, Dobrova and Sonja, Platzer and Felix, Bacher and Miljan, N M Milunovic and Anatolie, Dobrov and Spengler, Gabriella and Enyedy, Éva Anna and Ghenadie, Novitchi and Vladimir, B Arion}, doi = {10.1039/C6DT02784A}, journal-iso = {J CHEM SOC DALTON TRANS}, journal = {JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS}, volume = {45}, unique-id = {3096947}, issn = {1472-7773}, year = {2016}, pages = {13427-13439}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Enyedy, Éva Anna/0000-0002-8058-8128} } @article{MTMT:3135013, title = {Identification of Important Compounds Isolated from Natural Sources that Have Activity Against Multidrug-resistant Cancer Cell Lines: Effects on Proliferation, Apoptotic Mechanism and the Efflux Pump Responsible for Multi-resistance Phenotype}, url = {https://m2.mtmt.hu/api/publication/3135013}, author = {Amaral, L and Spengler, Gabriella and Molnár, József}, doi = {10.21873/anticanres.11149}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {36}, unique-id = {3135013}, issn = {0250-7005}, abstract = {The focus of this mini-review is to identify non-toxic compounds isolated from natural sources (plants) that exhibit specific activity against efflux pumps of specific multidrug-resistant (MDR) cancer cell lines, inhibit proliferation of the MDR cancer cell lines and inhibit the activity of overexpressed efflux pumps of the MDR cancer cell line.}, year = {2016}, eissn = {1791-7530}, pages = {5665-5672}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:3114913, title = {Efflux pump inhibiting properties of selenocompounds in bacteria}, url = {https://m2.mtmt.hu/api/publication/3114913}, author = {Kincses, Annamária and Ádám, Szabó Tönki and Marion, Szatmári and Mosolygó, Tímea and Enrique, Domínguez-Álvarez and Carmen, Sanmartín and Jadwiga, Handzlik and Spengler, Gabriella}, booktitle = {The meeting of "Bio-Selenium People in Europe"}, unique-id = {3114913}, year = {2016}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:3026841, title = {Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter}, url = {https://m2.mtmt.hu/api/publication/3026841}, author = {Armada, A and Martins, C and Spengler, Gabriella and Molnár, József and Amaral, L and Rodrigues, AS and Viveiros, M}, booktitle = {Cancer Drug Resistance}, doi = {10.1007/978-1-4939-3347-1_7}, unique-id = {3026841}, abstract = {The cell membrane P-glycoprotein (P-gp; MDR1, ABCB1) is an energy-dependent efflux pump that belongs to the ATP-binding cassette (ABC) family of transporters, and has been associated with drug resistance in eukaryotic cells. Multidrug resistance (MDR) is related to an increased expression and function of the ABCB1 (P-gp) efflux pump that often causes chemotherapeutic failure in cancer. Modulators of this efflux pump, such as the calcium channel blocker verapamil (VP) and cyclosporine A (CypA), can reverse the MDR phenotype but in vivo studies have revealed disappointing results due to adverse side effects. Currently available methods are unable to visualize and assess in a real-time basis the effectiveness of ABCB1 inhibitors on the uptake and efflux of ABCB1 substrates. However, predicting and testing ABCB1 modulation activity using living cells during drug development are crucial. The use of ABCB1-transfected mouse T-lymphoma cell line to study the uptake/efflux of fluorescent probes like ethidium bromide (EB), rhodamine 123 (Rh-123), and carbocyanine dye DiOC2, in the presence and absence of potential inhibitors, is currently used in our laboratories to evaluate the ability of a drug to inhibit ABCB1-mediated drug accumulation and efflux. Here we describe and compare three in vitro methods, which evaluate the permeability, transport kinetics of fluorescent substrates, and inhibition of the ABCB1 efflux pump by drugs of chemical synthesis or extracted from natural sources, using model cancer cell lines overexpressing this transporter, namely (1) real-time fluorimetry that assesses the accumulation of ethidium bromide, (2) flow cytometry, and (3) fluorescent microscopy using rhodamine 123 and DiOC2.}, year = {2016}, pages = {87-103}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3102607, title = {Coordination compounds of a hydrazone derivative with Co(III), Ni(II), Cu(II) and Zn(II): Synthesis, characterization, reactivity assessment and biological evaluation}, url = {https://m2.mtmt.hu/api/publication/3102607}, author = {Barta, Holló B and Magyari, József and Armaković, S and Bogdanović, GA and Rodić, MV and Armaković, SJ and Molnár, József and Spengler, Gabriella and Leovac, VM and Meszaros, Szecsenyi K}, doi = {10.1039/c6nj00560h}, journal-iso = {NEW J CHEM}, journal = {NEW JOURNAL OF CHEMISTRY}, volume = {40}, unique-id = {3102607}, issn = {1144-0546}, abstract = {A new hydrazone-type ligand with a five N-donor set and its coordination compounds with Co(iii), Ni(ii), Cu(ii) and Zn(ii) metal centres were synthesized. The crystal and molecular structure of the Co(iii) complex was determined by X-ray structural analysis. All the compounds were characterized by elemental analysis, molar conductivity and FT-IR spectral data. The cobalt(iii) compound is a neutral binuclear complex formed by coordination of two, doubly deprotonated ligand anions as bridges between the Co(iii) centres. The metal centres are additionally connected by a peroxido bridge, which was observed for the first time in Co(iii) complexes with similar ligands. The other coordination compounds are mononuclear complexes wherein only one doubly deprotonated ligand is coordinated to the central ion in a tetradentate fashion. The structures were theoretically investigated employing density functional theory (DFT) calculations with B3LYP exchange-correlation functional and LACV3P+(d,p) basis sets for the coordination compounds and 6-31+G(d,p) basis set for the ligand. Molecular electrostatic potential (MEP) and average local ionization energy (ALIE) surfaces were calculated to study the reactive properties of the compounds. The thermal behaviour of the compounds was determined by simultaneous thermogravimetric-differential scanning calorimetric (TG-DSC) measurements and the results were correlated to the proposed structures and to calculated MEP/ALIE surfaces. The compounds were tested in vitro for antiproliferative effects on parental (L5178Y) mouse T-cell lymphoma cells, on L5178Y transfected with pHa ABCB1/A retrovirus and for reversal of multidrug resistance (MDR) in tumor cells by flow cytometry. The preliminary measurements showed that the cobalt(iii) compound was an effective inhibitor of the ABC transporter PGP drug efflux pump. The ligand was somewhat less effective, the zinc complex had a moderate inhibition activity, whereas the nickel(ii) and copper(ii) compounds were inactive. © 2016 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.}, year = {2016}, eissn = {1369-9261}, pages = {5885-5895}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3076161, title = {Identification of selenocompounds with promising properties to reverse cancer multidrug resistance}, url = {https://m2.mtmt.hu/api/publication/3076161}, author = {Domínguez-Álvarez, E and Gajdács, Márió and Spengler, Gabriella and Palop, JA and Marć, MA and Kieć-Kononowicz, K and Amaral, L and Molnár, József and Jacob, C and Handzlik, J and Sanmartín, C}, doi = {10.1016/j.bmcl.2016.04.064}, journal-iso = {BIOORG MED CHEM LETT}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, volume = {26}, unique-id = {3076161}, issn = {0960-894X}, abstract = {In previous studies, 56 novel selenoesters and one cyclic selenoanhydride with chemopreventive, antiproliferative and cytotoxic activity were described. Herein, the selenoanhydride and selected selenoesters were evaluated for their ability to reverse the cancer multidrug resistance (MDR) using the ABCB1 efflux pump inhibition assay in mouse MDR T-lymphoma cells. Results showed that the selenoanhydride (1) and the selenoesters with ketone terminal fragments (9-11) exerted (1.7-3.6)-fold stronger efflux pump inhibitory action than the reference verapamil. In addition, those four derivatives triggered apoptotic events in more than 80% of the examined MDR mouse cells. © 2016 Elsevier Ltd.}, keywords = {APOPTOSIS; CANCER; Selenium; Multidrug resistance (MDR); MDR efflux pumps; UNFRMGHXKQDGNL-UHFFFAOYSA-N; Selenoesters; PHPMYXRXYSBCIU-UHFFFAOYSA-N; NVPAUJKABHDGEI-UHFFFAOYSA-N; AWLOFFRFIIJHKA-UHFFFAOYSA-N; ABCB1 efflux pump (P-glycoprotein)}, year = {2016}, eissn = {1464-3405}, pages = {2821-2824}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:3114911, title = {An overview of the different biological activities shown by selenoesters and selenoanhydrides}, url = {https://m2.mtmt.hu/api/publication/3114911}, author = {Enrique, Dominguez-Álvarez and Gajdács, Márió and Celia, Prior and Juan, Antonio Palop and Daniel, Plano and Carmen, Sanmartín and Karolina, Witek and Malgorzata, Anna Marc and Gniewormir, Latacz and Katarzyna, Kiec-Kononowicz and Jadwiga, Handzlik and Claus, Jacob and Spengler, Gabriella}, booktitle = {The meeting of "Bio-Selenium People in Europe"}, unique-id = {3114911}, year = {2016}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:3127394, title = {Redox-aktív szerves szelénvegyületek antitumor hatásának vizsgálata}, url = {https://m2.mtmt.hu/api/publication/3127394}, author = {Gajdács, Márió and Enrique, Domínguez-Álvarez and Jadwiga, Handzlik and Spengler, Gabriella}, booktitle = {XXXIX Kémiai Előadói Napok}, unique-id = {3127394}, year = {2016}, pages = {100-101}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3135011, title = {Fluorinated Beta-diketo Phosphorus Ylides Are Novel Efflux Pump Inhibitors in Bacteria}, url = {https://m2.mtmt.hu/api/publication/3135011}, author = {Kincses, Annamária and Szabó, Ágnes Míra and Saijo, R and Watanabe, G and Kawase, M and Molnár, József and Spengler, Gabriella}, doi = {10.21873/invivo.10999}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {30}, unique-id = {3135011}, issn = {0258-851X}, abstract = {BACKGROUND: One of the most important resistance mechanisms in bacteria is the increased expression of multidrug efflux pumps. To combat efflux-related resistance, the development of new efflux pump inhibitors is essential. MATERIALS AND METHODS: Ten phosphorus ylides were compared based on their MDR-reverting activity in multidrug efflux pump system consisting of the subunits acridine-resistance proteins A and B (AcrA and AcrB) and the multidrug efflux pump outer membrane factor TolC (TolC) of Escherichia coli K-12 AG100 strain and its AcrAB-TolC-deleted strain. Efflux inhibition was assessed by real-time fluorimetry and the inhibition of quorum sensing (QS) was also investigated. The relative gene expression of efflux QS genes was determined by real-time reverse transcriptase quantitative polymerase chain reaction. RESULTS: The most potent derivative was Ph3P=C(COC2F5)CHO and its effect was more pronounced on the AcrAB-TolC-expressing E. coli strain, furthermore the most active compounds, Ph3P=C(COCF3)OMe, Ph3P=C(COC2F5)CHO and Ph3P=C(COCF3)COMe, reduced the expression of efflux pump and QS genes. CONCLUSION: Phosphorus ylides might be valuable EPI compounds to reverse efflux related MDR in bacteria.}, year = {2016}, eissn = {1791-7549}, pages = {813-817}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2990683, title = {Silver nanoparticles modulate ABC transporter activity and enhance chemotherapy in multidrug resistant cancer}, url = {https://m2.mtmt.hu/api/publication/2990683}, author = {Kovács, Dávid and Szőke, Krisztina and Igaz, Nóra and Spengler, Gabriella and Molnár, József and Tóth, Tímea and Madarász, Dániel and Rázga, Zsolt and Kónya, Zoltán and Boros, Imre Miklós and Csontné Kiricsi, Mónika}, doi = {10.1016/j.nano.2015.10.015}, journal-iso = {NANOMED: NANOTECHNOL}, journal = {NANOMEDICINE: NANOTECHNOLOGY BIOLOGY AND MEDICINE}, volume = {12}, unique-id = {2990683}, issn = {1549-9634}, abstract = {Abstract The emergence of multidrug resistant (MDR) cancer phenotypes dramatically attenuates the efficiency of antineoplastic drug treatments often leading to the failure of chemotherapy. Therefore there is an urgent need to engineer new therapeutically useful agents and propose innovative approaches able to defeat resistant cancer cells. Although the remarkable anti-cancer features of silver nanoparticles (AgNPs) have already been delineated their impact on MDR cancer has never been investigated. Herein, we report that AgNPs have a notable anti-proliferative effect and induce apoptosis mediated cell death both in drug sensitive and in MDR cancer cells. Furthermore we show evidence that AgNPs exert an inhibitory action on the efflux activity of MDR cancer cells which feature could be exploited to enhance drug accumulation. We verified synergistic interactions of AgNPs with six different antineoplastic agents on drug resistant cells which emphasizes the excellent potential of AgNPs as combinational partners in the chemotherapy of MDR cancer.}, keywords = {multidrug resistance; Silver nanoparticles; combinational therapy}, year = {2016}, eissn = {1549-9642}, pages = {601-610}, orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Spengler, Gabriella/0000-0001-8085-0950; Rázga, Zsolt/0000-0003-4717-8482; Kónya, Zoltán/0000-0002-9406-8596; Boros, Imre Miklós/0000-0001-8504-9687; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @CONFERENCE{MTMT:3114912, title = {Evaluation of selenoester derivatives with potential efflux pump inhibiting and apoptosis inducing properties on cancer cells}, url = {https://m2.mtmt.hu/api/publication/3114912}, author = {Gajdács, Márió and Enrique, Domínguez-Álvarez and Jadwiga, Handzlik and Carmen, Sanmartín and Spengler, Gabriella}, booktitle = {The meeting of "Bio-Selenium People in Europe"}, unique-id = {3114912}, year = {2016}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3102606, title = {Jatrophane diterpenes and cancer multidrug resistance - ABCB1 efflux modulation and selective cell death induction}, url = {https://m2.mtmt.hu/api/publication/3102606}, author = {Reis, MA and Ahmed, OB and Spengler, Gabriella and Molnár, József and Lage, H and Ferreira, M-JU}, doi = {10.1016/j.phymed.2016.05.007}, journal-iso = {PHYTOMEDICINE}, journal = {PHYTOMEDICINE: INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY}, volume = {23}, unique-id = {3102606}, issn = {0944-7113}, abstract = {Background Modulation of P-glycoprotein (ABCB1) and evaluation of the collateral sensitivity effect are among the most promising approaches to overcome multidrug resistance (MDR) in cancer. In a previous study, two rare 12,17-cyclojatrophanes (1-2) and other novel jatrophanes (3-4), isolated from Euphorbia welwitschii, were screened for collateral sensitivity effect. Herein, the isolation of another jatrophane (5) is presented, being the broader goal of this work to investigate the role of euphowelwitschines A (1) and B (2), welwitschene (3), epoxywelwitschene (4) and esulatin M (5) as ABCB1 modulators and/or collateral sensitivity agents. Methods Compounds 1-5 were evaluated for ABCB1 modulation ability through combination of transport and chemosensitivity assays, using a mouse T-lymphoma MDR1-transfected cell model. Moreover, the nature of interaction of compound 4 with ABCB1 was studied, using an ATPase assay. The MDR-selective antiproliferative activity of compound 5 was evaluated against gastric (EPG85-257) and pancreatic (EPP85-181) human cancer cells and their drug-selected counterparts (EPG85-257RDB, EPG85-257RNOV, EPP85-181RDB, EPP85-181RNOV). The drug induced cell death was investigated for compounds 4 and 5, using the annexin V/PI staining and the active caspase-3 assay. Results The jatrophanes 1-5 were able to modulate the efflux activity of ABCB1, and at 2 μM, 3-5 maintained the strong modulator profile. Structure activity results indicated that high conformational flexibility of the twelve-membered ring of compounds 3-5 favored ABCB1 modulation, in contrast to the tetracyclic scaffold of compounds 1 and 2. The effects of epoxywelwitschene (4) on the ATPase activity of ABCB1 showed it to interact with the transporter and to be able to reduce the transport of a second subtrate. Drug combination experiments also corroborated the anti-MDR potential of these diterpenes due to their synergistic interaction with doxorubicin (combination index < 0.7). Esulatin M (5) showed a strong MDR-selective antiproliferative activity against EPG85-257RDB and EPP85-181RDB cells, with IC50 of 1.8 and 4.8 μM, respectively. Compounds 4 and 5 induced apoptosis via caspase-3 activation. A significant discrimination was observed between the resistant cell lines and parental cells. Conclusions This study strengthens the role of jatrophane diterpenes as lead candidates for the development of MDR reversal agents, higlighting the action of compounds 4 and 5. © 2016 Elsevier GmbH.}, keywords = {APOPTOSIS; multidrug resistance; COLLATERAL SENSITIVITY; JATROPHANE; ABCB1; 12,17-cyclojatrophane}, year = {2016}, eissn = {1618-095X}, pages = {968-978}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3135012, title = {The Anticancer Activity of the Old Neuroleptic Phenothiazine-type Drug Thioridazine}, url = {https://m2.mtmt.hu/api/publication/3135012}, author = {Spengler, Gabriella and Csonka, Ákos and Molnár, József and Amaral, L}, doi = {10.21873/anticanres.11153}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {36}, unique-id = {3135012}, issn = {0250-7005}, abstract = {Thioridazine (TZ), an antipsychotic drug, renders multidrug-resistant (MDR) cancer cells susceptible to cytotoxic agents to which they were initially resistant, has anti-prolilferative activity and apoptosis-inducing properties in various tumor cell lines and cancer stem cells. Whereas the anti-proliferative activity takes place at high concentrations that ensure the intercalation of the compound between nucleic bases (especially rich in G/C bases), much lower concentrations inhibit the export function of the ABCB1 (P-glycoprotein), which is responsible for the MDR phenotype of the cancer cell. The co-administration of TZ with doxorubicin inhibits efflux of doxorubicin and, hence, increases the intracellular concentration of anticancer drug. The (+) and (-) enantiomers of TZ have the same activities as TZ. The main focus of this review is to present extensive evidence provided by our work, confirmed by much later studies, as it supports adjuvant use of TZ with an anticancer drug for MDR cancer therapy.}, year = {2016}, eissn = {1791-7530}, pages = {5701-5706}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3083954, title = {The 5-aromatic hydantoin-3-acetate derivatives as inhibitors of the tumour multidrug resistance efflux pump P-glycoprotein (ABCB1): Synthesis, crystallographic and biological studies}, url = {https://m2.mtmt.hu/api/publication/3083954}, author = {Zeslawska, E and Kincses, Annamária and Spengler, Gabriella and Nitek, W and Wyrzuc, K and Kiec-Kononowicz, K and Handzlik, J}, doi = {10.1016/j.bmc.2016.04.055}, journal-iso = {BIOORGAN MED CHEM}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, volume = {24}, unique-id = {3083954}, issn = {0968-0896}, abstract = {A series of arylpiperazine derivatives of hydantoin-3-acetate, including previously obtained 5,5-diphenylhydantoin (1-7) and new-synthesized spirofluorene-hydantoin derivatives (8-12), were investigated in the search for new inhibitors of the tumour multidrug resistance (MDR) efflux pump P-glycoprotein (P-gp, ABCB1) overexpressed in mouse T-lymphoma cells. Synthesis of new compounds (8-12) was performed. Crystal structures of two compounds (8 and 11) were determined by X-ray diffraction method. The conformations of the investigated molecules (8 and 11) in the crystalline samples are different. The bent conformation seems to be more favourable for biological activity than the extended one. The efflux pump inhibitory properties of the compounds 1-12 were evaluated in the fluorescence uptake assay using rhodamine 123 dye in mouse T-lymphoma model in vitro. Their cytotoxic action was examined, too. All compounds with methyl acetate moiety displayed high potency to inhibit the MDR efflux pump. The most active compound, methyl 2-(1-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-5,5-diphenylhydantoin-3-yl)a cetate (5), tested at 1/10 of verapamil concentration displayed the 9-fold higher P-gp inhibitory action.}, year = {2016}, eissn = {1464-3391}, pages = {2815-2822}, orcid-numbers = {Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2879234, title = {Substituted steroidal compounds containing amino and amido groups reverse multidrug resistance of mouse T-lymphoma and two human prostate cancer cell lines in vitro}, url = {https://m2.mtmt.hu/api/publication/2879234}, author = {Csonka, Ákos and Hamdoun, S and Spengler, Gabriella and Martins, Ana and Vincze, I and Efferth, T and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {35}, unique-id = {2879234}, issn = {0250-7005}, abstract = {BACKGROUND: Resistance to chemotherapy is a main problem in cancer. The search for new effective compounds that can increase sensitivity of resistant cells to existing chemotherapeutics is an urgent need. In previous studies, it has been demonstrated that steroid derivatives showed promising results concerning their capacity to modulate resistance of multidrug-resistant cell lines. MATERIALS AND METHODS: Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multidrug resistance, apoptosis induction, and interaction with doxorubicin on multidrug resistant human ATP-binding cassette, sub-family B, member 1 (ABCB1) gene-transfected mouse T-lymphoma cell line, and human PC-3 and LNCaP prostate cancer cell lines in vitro. The steroidal interaction with P-glycoprotein (ABCB1) was investigated by molecular docking. RESULTS: Both the activity of steroid derivatives on inhibition of the ABCB1 pump and their interaction with doxorubicin are dependent on the substituent groups of the investigated steroidal structures. Even though the investigated steroid derivatives were found to have limited antiproliferative effect on the three different cancer cell lines, in combination with doxorubicin, most of them acted as good potentiators. The binding energies from molecular docking ranged from -6.43 to -9.88 kcal/mol. The predicted inhibition constants ranged from 0.1 to 10.1 muM. A significant negative correlation was found between binding energy and fluorescence activity ratio (R=-0.5, p=0.015). CONCLUSION: The effective compounds can be candidates of model molecules for possible application in the treatment of multidrug resistant cancer in rational drug design.}, year = {2015}, eissn = {1791-7530}, pages = {2105-2112}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:2879380, title = {Resistance Mechanisms in Silver-Citrate Nanoparticle Treated Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/2879380}, author = {Kovács, Dávid and Igaz, Nóra and Keskeny, Csilla and Szőke, Krisztina and Rigó, Réka and Tóth, Tímea and Spengler, Gabriella and Kónya, Zoltán and Boros, Imre Miklós and Csontné Kiricsi, Mónika}, booktitle = {Hungarian Molecular Life Sciences 2015}, unique-id = {2879380}, year = {2015}, pages = {175-175}, orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Spengler, Gabriella/0000-0001-8085-0950; Kónya, Zoltán/0000-0002-9406-8596; Boros, Imre Miklós/0000-0001-8504-9687; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:3063460, title = {REVERSAL OF MULTIDRUG RESISTANCE BY SELENOESTER DERIVATIVES}, url = {https://m2.mtmt.hu/api/publication/3063460}, author = {Gajdács, Márió and ENRIQUE, DOMÍNGUEZ-ÁLVAREZ and JADWIGA, HANDZLIK and Burián, Katalin and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {62}, unique-id = {3063460}, issn = {1217-8950}, year = {2015}, eissn = {1588-2640}, pages = {154-154}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Burián, Katalin/0000-0003-1300-2374; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3040889, title = {Exploring epoxylathyrane derivatives to overcome ABCB1-mediated multidrug resistance in human colon adenocarcinoma cells}, url = {https://m2.mtmt.hu/api/publication/3040889}, author = {Matos, AM and Reis, M and Spengler, Gabriella and Molnár, József and Duarte, N and Ferreira, MJU}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {81}, unique-id = {3040889}, issn = {0032-0943}, year = {2015}, eissn = {1439-0221}, pages = {1454-1455}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2951177, title = {Epoxylathyrol Derivatives: Modulation of ABCB1-Mediated Multidrug Resistance in Human Colon Adenocarcinoma and Mouse T-Lymphoma Cells}, url = {https://m2.mtmt.hu/api/publication/2951177}, author = {Matos, AM and Reis, M and Duarte, N and Spengler, Gabriella and Molnár, József and Ferreira, MJ}, doi = {10.1021/acs.jnatprod.5b00370}, journal-iso = {J NAT PROD}, journal = {JOURNAL OF NATURAL PRODUCTS}, volume = {78}, unique-id = {2951177}, issn = {0163-3864}, abstract = {Epoxyboetirane A (1), a macrocyclic diterpene that was found to be inactive as an ABCB1 modulator, was submitted to several chemical transformations, aimed at generating a series of compounds with improved multidrug resistance (MDR)-modifying activity. Overall, 23 new derivatives were prepared, in addition to the already reported epoxylathyrol (2) and methoxyboetirol (3). Their anti-MDR potential was assessed through both functional and chemosensitivity assays on resistant human colon adenocarcinoma and human ABCB1-gene transfected L5178Y mouse lymphoma cells. Structure-activity relationship analysis showed that different substitution patterns led to distinct ABCB1 inhibitory activities, although intrinsic cellular characteristics seemed to influence the modulatory behavior. A considerable enhancement in MDR-modifying activity was observed for aromatic compounds in both cell lines, particularly in 3,17-disubstituted esters derived from 3, a Payne-rearranged Michael adduct of 2. All compounds tested were revealed to interact synergistically with doxorubicin, and ATPase inhibition by three representative MDR-modifying compounds was also investigated. On account of its outstanding ABCB1 inhibitory activity at 0.2 muM and overall remarkable bioactive profile, methoxyboetirane B (22) was found to be a new promising lead for MDR-reversing anticancer drug development.}, year = {2015}, eissn = {1520-6025}, pages = {2215-2228}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2962208, title = {Fluorinated beta-Diketo Phosphorus Ylides Are Novel Inhibitors of the ABCB1 Efflux Pump of Cancer Cells.}, url = {https://m2.mtmt.hu/api/publication/2962208}, author = {Spengler, Gabriella and Ocsovszki, Imre and Tonki, AS and Saijo, R and Watanabe, G and Kawase, M and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {35}, unique-id = {2962208}, issn = {0250-7005}, abstract = {Efflux pump inhibitors are attractive compounds that reverse multidrug resistance (MDR) in cancer cells. In the present study, 10 phosphorus ylides (P-ylides) were compared based on their MDR-reverting activity in human ATP-binding cassette sub-family B member 1 (ABCB1; P-glycoprotein) gene-transfected L5178Y mouse T-lymphoma cells. Among them, three P-ylides, Ph3P=C(COCF3)COPh, Ph3P=C(COC2F5)COPh and Ph3P=C(COC3F7)COPh were identified as selectively modulating the ABCB1 pump. These compounds, with low cytotoxicity against mouse T-lymphoma cells, exhibited more potency than the positive control ABCB1 inhibitor verapamil.}, year = {2015}, eissn = {1791-7530}, pages = {5915-5919}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Ocsovszki, Imre/0000-0003-1290-996X} } @misc{MTMT:2901849, title = {The anti-chlamydial effect of phenothiazines and disiloxane derivatives}, url = {https://m2.mtmt.hu/api/publication/2901849}, author = {Spengler, Gabriella and Mosolygó, Tímea and Molnár, József and Csonka, Andrea and Csonka, Ákos and Amaral, Leonard and Burián, Katalin}, unique-id = {2901849}, year = {2015}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Mosolygó, Tímea/0000-0002-4499-388X; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:2901785, title = {Reversal of ABCB1-related Multidrug Resistance of Colonic Adenocarcinoma Cells by Phenothiazines.}, url = {https://m2.mtmt.hu/api/publication/2901785}, author = {Takács, Daniella and Csonka, Ákos and Horváth, Ádám and Windt, Tímea and Gajdács, Márió and Riedl, Zsuzsanna and Hajós, György and Amaral, L and Molnár, József and Spengler, Gabriella}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {35}, unique-id = {2901785}, issn = {0250-7005}, abstract = {BACKGROUND: The most common mechanism that reduces the efficacy of anticancer agents is overexpression of ATP-binding cassette (ABC) drug transporters. Phenothiazines and structurally-related compounds can sensitize multidrug-resistant (MDR) cells to chemotherapeutics. MATERIALS AND METHODS: Phenothiazine derivatives were investigated regarding their anticancer and MDR-reversing effect on colonic adenocarcinoma cells. The anti-proliferative and cytotoxic effects of the derivatives were assessed by the thiazolyl blue tetrazolium bromide (MTT) method, the modulation of the ABCB1 activity was measured by rhodamine 123 accumulation assay using flow cytometry. RESULTS: All phenothiazines exhibited potent cytotoxic effect on the sensitive and MDR colon adenocarcinoma cell lines. The inhibition of the ABCB1 transporter was greater in the presence of the phenothiazine derivatives than for the known ABCB1 inhibitor verapamil. CONCLUSION: It can be concluded that these derivatives show synergism in the presence of doxorubicin and could have potential as ABCB1 inhibitors.}, year = {2015}, eissn = {1791-7530}, pages = {3245-3251}, orcid-numbers = {Windt, Tímea/0000-0001-9913-3337; Gajdács, Márió/0000-0003-1270-0365; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3063503, title = {NEW PERSPECTIVES IN THE TREATMENT OF CHLAMYDIA TRACHOMATIS INFECTIONS: PHENOTHIAZINES AND DISILOXANE DERIVATIVES AS POTENTIAL ANTI-CHLAMYDIAL AGENTS}, url = {https://m2.mtmt.hu/api/publication/3063503}, author = {Mosolygó, Tímea and MARION, SZATMÁRI and Molnár, József and Csonka, Andrea and Csonka, Ákos and LEONARD, AMARAL and Burián, Katalin and Spengler, Gabriella}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {62}, unique-id = {3063503}, issn = {1217-8950}, year = {2015}, eissn = {1588-2640}, pages = {182-183}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Burián, Katalin/0000-0003-1300-2374; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2757032, title = {COMPARISON OF CYTOTOXICITY OF BUTYL-OXI-CARBONYL SUBSTITUTED STEROIDAL COMPOUNDS ON DIFFERENT CANCER CELL LINES IN VITRO}, url = {https://m2.mtmt.hu/api/publication/2757032}, author = {Csonka, Ákos and Spengler, Gabriella and Martins, Ana and Irén, Vincze and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {34}, unique-id = {2757032}, issn = {0250-7005}, year = {2014}, eissn = {1791-7530}, pages = {5870-5871}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2497680, title = {Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them}, url = {https://m2.mtmt.hu/api/publication/2497680}, author = {Amaral, Leonard and Martins, Ana and Spengler, Gabriella and Molnár, József}, doi = {10.3389/fphar.2013.00168}, journal-iso = {FRONT PHARMACOL}, journal = {FRONTIERS IN PHARMACOLOGY}, volume = {4}, unique-id = {2497680}, year = {2014}, eissn = {1663-9812}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2757039, title = {Multidrug resistance reversal by phenothiazines on p glycoprotein-related resistance of colon adenocarcinoma cells}, url = {https://m2.mtmt.hu/api/publication/2757039}, author = {Szabó, Ágnes Míra and Spengler, Gabriella and D, Takács and Zs, Riedl and Gy, Hajós and L, Amaral and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {34}, unique-id = {2757039}, issn = {0250-7005}, year = {2014}, eissn = {1791-7530}, pages = {6196-6197}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2769946, title = {Improving the MDR reversal activity of 6,17-epoxylathyrane diterpenes}, url = {https://m2.mtmt.hu/api/publication/2769946}, author = {Cátia, Vieira and Noélia, Duarte and Mariana, A Reis and Spengler, Gabriella and Ana, Margarida Madureira and Molnár, József and Maria-José, U Ferreira}, doi = {10.1016/j.bmc.2014.09.041}, journal-iso = {BIOORGAN MED CHEM}, journal = {BIOORGANIC & MEDICINAL CHEMISTRY}, volume = {22}, unique-id = {2769946}, issn = {0968-0896}, year = {2014}, eissn = {1464-3391}, pages = {6392-6400}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:2526922, title = {Anticancer activity of thioridazine stereoisomers}, url = {https://m2.mtmt.hu/api/publication/2526922}, author = {Csonka, Ákos and Spengler, Gabriella and Martins, Ana and Ocsovszki, Imre and Chritsten, Jorn B and Hendricks, Oliver and Kristiansen, Jette E and Amaral, Leonard and Molnár, József}, booktitle = {ICACT 2014}, unique-id = {2526922}, year = {2014}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Ocsovszki, Imre/0000-0003-1290-996X} } @article{MTMT:2757043, title = {Analysis of the interaction of normal human fibroblasts and different cancer cells in mixed cultures by xcelligence studies}, url = {https://m2.mtmt.hu/api/publication/2757043}, author = {Szabó, Diána and Spengler, Gabriella and Molnár, József and Gábor, Tax and Kornélia, Szabó and Rovó, László}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {34}, unique-id = {2757043}, issn = {0250-7005}, year = {2014}, eissn = {1791-7530}, pages = {6197-6197}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Rovó, László/0000-0003-1782-1756} } @CONFERENCE{MTMT:2820018, title = {The role of chirality in the efflux pump inhibiting properties of phenothiazine derivatives on the bacterial AcrAB-TolC system}, url = {https://m2.mtmt.hu/api/publication/2820018}, author = {Spengler, Gabriella and Daniella, Takács and Horváth, Ádám and Zsuzsanna, Riedl and György, Hajós and Molnár, József and Burián, Katalin}, booktitle = {International Congress of Bacteriology and Applied Microbiology during the International Union of Microbiological Societies General Assembly}, unique-id = {2820018}, year = {2014}, pages = {1216-1216}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:2757059, title = {Thioxanthone compounds to reduce tumor growth, cancer cachexia and cancer treatment-related bone marrow toxicity}, url = {https://m2.mtmt.hu/api/publication/2757059}, author = {Spengler, Gabriella and Ilona, Mucsi and Ferenc, Uher and Peter, Hegyes and Orsolya, Csuka and Molnár, József and Zoltán, Kiss}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {34}, unique-id = {2757059}, issn = {0250-7005}, year = {2014}, eissn = {1791-7530}, pages = {6180-6180}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2817308, title = {Resistance mechanisms in silver-citrate nanoparticles treated colon cancer cells}, url = {https://m2.mtmt.hu/api/publication/2817308}, author = {Kovács, Dávid and Igaz, Nóra and Keskeny, C and Toth, T and Spengler, Gabriella and Kónya, Zoltán and Boros, Imre Miklós and Csontné Kiricsi, Mónika}, journal-iso = {FEBS J}, journal = {FEBS JOURNAL}, volume = {281}, unique-id = {2817308}, issn = {1742-464X}, year = {2014}, eissn = {1742-4658}, pages = {161-162}, orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Spengler, Gabriella/0000-0001-8085-0950; Kónya, Zoltán/0000-0002-9406-8596; Boros, Imre Miklós/0000-0001-8504-9687; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:3049294, title = {Synergism between Antiplasmid Promethazine and Antibiotics In Vitro and In Vivo}, url = {https://m2.mtmt.hu/api/publication/3049294}, author = {Molnár, József and Mándi, Yvette and Spengler, Gabriella and Haszon, I and Turi, S and Kásler, Miklós and Amaral, L}, doi = {10.4172/2167-0501.1000139}, journal-iso = {BIOCHEM PHARMACOL}, journal = {BIOCHEMISTRY AND PHARMACOLOGY}, volume = {3}, unique-id = {3049294}, year = {2014}, eissn = {2167-0501}, orcid-numbers = {Mándi, Yvette/0000-0003-4729-2445; Spengler, Gabriella/0000-0001-8085-0950; Kásler, Miklós/0000-0002-7235-8787} } @article{MTMT:2866957, title = {Lathyrane diterpenes from Euphorbia boetica and Euphorbia pedroi: Promising ABCB1 modulators for overcoming multidrug resistance}, url = {https://m2.mtmt.hu/api/publication/2866957}, author = {Neto, S and Vieira, C and Matos, A M and Monico, A and Ferreira, R and Reis, M and Pedro, C and Madureira, A M and Spengler, Gabriella and Molnár, József and Duarte, N and Ferreira, M J U}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {80}, unique-id = {2866957}, issn = {0032-0943}, year = {2014}, eissn = {1439-0221}, pages = {1412-1412}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:2821479, title = {Resistance Mechanisms in Silver-Citrate Nanoparticle Treated Colon Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/2821479}, author = {Igaz, Nóra and Kovács, Dávid and Csilla, Keskeny and Tímea, Tóth and Spengler, Gabriella and Kónya, Zoltán and Boros, Imre Miklós and Csontné Kiricsi, Mónika}, booktitle = {SIWAN6: 6th Szeged International Workshop on Advances in Nanoscience}, unique-id = {2821479}, year = {2014}, pages = {97-98}, orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Spengler, Gabriella/0000-0001-8085-0950; Kónya, Zoltán/0000-0002-9406-8596; Boros, Imre Miklós/0000-0001-8504-9687; Csontné Kiricsi, Mónika/0000-0002-8416-2052} } @article{MTMT:2774700, title = {Efflux Pump Inhibiting Properties of Racemic Phenothiazine Derivatives and their Enantiomers on the Bacterial AcrAB-TolC System.}, url = {https://m2.mtmt.hu/api/publication/2774700}, author = {Spengler, Gabriella and Takács, Daniella and Horváth, Ádám and Szabó, Ágnes Míra and Riedl, Zsuzsanna and Hajós, György and Molnár, József and Burián, Katalin}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {28}, unique-id = {2774700}, issn = {0258-851X}, abstract = {Background/Aim: Bacterial resistance to antibiotics has become a serious problem in antibacterial chemotherapy and resistance of bacteria to chemically-unrelated anti-microbial agents can be associated with the over-expression of efflux pumps. The simultaneous therapy with efflux pump inhibitors (EPIs) could be a solution to improve the effectiveness of antibiotics. The response of an organism to an EPI often depends on how that molecule fits a particular site of a protein. Because enantiomers of a given compound rotate plane-polarized light in a solution by the same angle but in opposite directions, the rational drug design should take the chirality into account if there is a difference between the racemic compound and its enantiomers. Materials and Methods: The main goal of the present study was to elucidate the role of chirality of N-hydroxyalkyl-2-aminophenothiazines as effective EPIs by an automated method that uses the general efflux pump substrate ethidium bromide (EB) for the assessment of AcrAB-TolC system of wild-type Escherichia coli K-12 AG100. It has been shown that the most active EPIs among the N-hydroxyalkyl-2-aminophenothiazines were the compounds rac-3i, (+)-3i, and (-)-3i by modulating the AcrAB-TolC efflux pump. Conclusion: Comparison of effects of enantiomeric pairs revealed that their activities were similar to that of racemic derivatives. Moreover, there was no significant difference between the racemic compounds and their enantiomers related to their antibacterial and efflux pump inhibiting effects.}, year = {2014}, eissn = {1791-7549}, pages = {1071-1075}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:2583773, title = {Multidrug Resistance Reversing Activity of Newly Developed Phenothiazines on P-glycoprotein (ABCB1)-related Resistance of Mouse T-Lymphoma Cells.}, url = {https://m2.mtmt.hu/api/publication/2583773}, author = {Spengler, Gabriella and Takács, Daniella and Horváth, Ádám and Riedl, Zsuzsanna and Hajós, György and Amaral, L and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {34}, unique-id = {2583773}, issn = {0250-7005}, abstract = {BACKGROUND: Phenothiazines have anticancer properties and are able to reverse the multidrug resistance of neoplastic cells by inhibiting the ATP-binding cassette, sub-family B (MDR/TAP), member 1 protein (ABCB1 or P-glycoprotein) activity. MATERIALS AND METHODS: A series of new phenothiazine derivatives was investigated regarding their ABCB1-modulating effect on multidrug resistant mouse T-lymphoma cells by rhodamine 123 accumulation assay and real-time ethidium bromide accumulation assay. RESULTS: The phenothiazine derivatives exhibited a potent anticancer effect on the parental cell line and on its multidrug-resistant mouse T-lymphoma subline overexpressing the ABCB1 transporter. The inhibition of the ABCB1 transporter in the presence of the newly-developed phenothiazines was greater than that for the known ABCB1 inhibitors thioridazine and verapamil. CONCLUSION: Based on the chemical structures and biological activity, compounds with bivalent sulfur atom in the phenothiazine ring demonstrated marked ABCB1-modulating effect, however, other derivatives with halogen or amide substitutions were ineffective.}, keywords = {Animals; metabolism; MICE; GENETICS; ARTICLE; MOUSE; P-GLYCOPROTEIN; animal; Chemistry; cell proliferation; drug effect; Cell Line, Tumor; verapamil; Drug Resistance; Gene Expression; antineoplastic agent; multidrug resistance; Antineoplastic Agents; T cell lymphoma; Drug Resistance, Multiple; Drug Resistance, Neoplasm; phenothiazine derivative; Phenothiazines; phenothiazine; rhodamine 123; tumor cell line; thioridazine; Lymphoma, T-Cell; P-Glycoproteins; multidrug resistance protein; ABCB1; Ethidium bromide; mouse T-lymphoma cell lines; ATP-binding cassette protein B1}, year = {2014}, eissn = {1791-7530}, pages = {1737-1741}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2779840, title = {Multidrug resistance reversing activity of newly developed phenothiazines on p glycoprotein (abcb1)-related resistance in different cancer models}, url = {https://m2.mtmt.hu/api/publication/2779840}, author = {Spengler, Gabriella and Takacs, Daniella and Riedl, Zsuzsanna and Hajos, György and Amaral, Leonard and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {34}, unique-id = {2779840}, issn = {0250-7005}, year = {2014}, eissn = {1791-7530}, pages = {6180-6181}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:2583760, title = {INHIBITORS OF EFFLUX PUMPS IN GRAM-NEGATIVE BACTERIA TO COMBAT MULTIDRUG RESISTANCE}, url = {https://m2.mtmt.hu/api/publication/2583760}, author = {Spengler, Gabriella and Takács, Daniella and Handzlik, Jadwiga and Kiec-Kononowicz, Katarzyna and Amaral, Leonard}, booktitle = {I. Innovation in Science - Doctoral Student Conference 2014}, unique-id = {2583760}, year = {2014}, pages = {165-166}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:2526895, title = {Studies of phenylpiperazine derivatives of 5,5-dimethylhydantion on the modulation of multidrug efflux pumps of cancer cells}, url = {https://m2.mtmt.hu/api/publication/2526895}, author = {Spengler, Gabriella and Handzlik, Jadwiga and Szabó, Ágnes Míra and Karcz, Tadeusz and Olejarz, Agnieszka and Amaral, Leonard and Molnár, József and Kiec-Kononowicz, Katarzyna}, booktitle = {ICACT 2014}, unique-id = {2526895}, year = {2014}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2755751, title = {Efflux Pumps that Bestow Multi-Drug Resistance of Pathogenic Gramnegative Bacteria}, url = {https://m2.mtmt.hu/api/publication/2755751}, author = {Amaral, L and Spengler, Gabriella and Martins, Ana and Molnár, József}, doi = {10.4172/2167-0501.1000119}, journal-iso = {BIOCHEM PHARMACOL}, journal = {BIOCHEMISTRY AND PHARMACOLOGY}, volume = {2}, unique-id = {2755751}, year = {2013}, eissn = {2167-0501}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2475746, title = {The mechanism by which the phenothiazine thioridazine contributes to cure problematic drug-resistant forms of pulmonary tuberculosis: Recent patents for "new use"}, url = {https://m2.mtmt.hu/api/publication/2475746}, author = {Amaral, Leonard and Martins, Ana and Spengler, Gabriella and Hunyadi, Attila and Molnár, József}, doi = {10.2174/1574891X08666131210141521}, journal-iso = {REC PATENTS ANTI-INFECT DRUG DISCOV}, journal = {RECENT PATENTS ON ANTI-INFECITVE DRUG DISCOVERY}, volume = {8}, unique-id = {2475746}, issn = {1574-891X}, abstract = {At this moment, over half million patients suffer from multi-drug resistant tuberculosis (MDRTB) according to the data from the WHO. A large majority is terminally ill with essentially incurable pulmonary tuberculosis. This herein mini-review provides the experimental and observational evidence that a specific phenothiazine, thioridazine, will contribute to cure any form of drug-resistant tuberculosis. This antipsychotic agent is no longer under patent protection for its initial use. The reader is informed on the recent developments in patenting this compound for "new use" with a special emphasis on the aspects of drug-resistance, and, given that economic motivation can stimulate the use of this drug as an antitubercular agent, future prospects are also discussed.}, year = {2013}, eissn = {2212-4071}, pages = {206-212}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:2470103, title = {Effect of thioridazine stereoisomers on the drug accumulation of mouse lymphoma and human prostate cancer cell lines in vitro.}, url = {https://m2.mtmt.hu/api/publication/2470103}, author = {Csonka, Ákos and Spengler, Gabriella and Martins, Ana and Ocsovszki, Imre and Christensen, JB and Hendricks, O and Kristiansen, JE and Amaral, L and Molnár, József}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {27}, unique-id = {2470103}, issn = {0258-851X}, abstract = {BACKGROUND: Cancer cells become refractory to chemotherapy as a consequence of their overexpression of multidrug transporters. MATERIALS AND METHODS: The anticancer and multidrug resistance (MDR) reversal effects of the racemic form and the two enantiomers of thoridazine were investigated on a mouse T-lymphoma cell line over-expressing the ATP-binding cassette, subfamily-B (MDR/TAP), member 1 (ABCB1) transporter (also known as P-glycoprotein) and on human PC3 prostate cancer cell line by 3-(4.5-dimethylthiazolyl-2)-2.5-diphenyl tetrazolium bromide (MTT) assay. The modulation of ABCB1 transporter activity was studied by rhodamine123 accumulation, the apoptosis-inducing effect was investigated using fluorescein isothiocyanate (FITC)-labeled annexin V and propidium iodide. RESULTS: The thioridazine racemic and (+) and (-) enantiomers were similarly effective. Drug accumulation by MDR mouse T-lymphoma cells was moderately modified in the presence of thioridazine derivatives. Thioridazine induced apoptosis of the MDR cancer cell line, but there was no significant apoptotic effect on the PC3 cell line. CONCLUSION: Apparently, the chirality of thioridazine has no importance in the inhibition of MDR phenotype of cancer cells.}, year = {2013}, eissn = {1791-7549}, pages = {815-820}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Ocsovszki, Imre/0000-0003-1290-996X} } @article{MTMT:2470652, title = {The Role of Stroma in Tumour-Host Co-Existence: Some Perspectives in Stroma-Targeted Therapy of Cancer}, url = {https://m2.mtmt.hu/api/publication/2470652}, author = {Molnár, József and Mucsi, Ilona and Engi, Helga and Spengler, Gabriella and Amaral, Leonard and Zalatnai, Attila and Wang, Qi and Shlomo, Ben Efraim}, doi = {10.4172/2167-0501.1000107}, journal-iso = {BIOCHEM PHARMACOL}, journal = {BIOCHEMISTRY AND PHARMACOLOGY}, volume = {2}, unique-id = {2470652}, year = {2013}, eissn = {2167-0501}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Zalatnai, Attila/0000-0001-6334-8336} } @article{MTMT:2473515, title = {IL-17E Production Is Elevated in the Lungs of Balb/c Mice in the Later Stages of Chlamydia muridarum Infection and Re-infection}, url = {https://m2.mtmt.hu/api/publication/2473515}, author = {Mosolygó, Tímea and Spengler, Gabriella and Endrész, Valéria and Laczi, Krisztián and Perei, Katalin and Burián, Katalin}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {27}, unique-id = {2473515}, issn = {0258-851X}, year = {2013}, eissn = {1791-7549}, pages = {787-792}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950; Endrész, Valéria/0000-0002-9402-3857; Laczi, Krisztián/0000-0002-9399-7406; Perei, Katalin/0000-0001-8989-2284; Burián, Katalin/0000-0003-1300-2374} } @article{MTMT:2465663, title = {IL-17E production is elevated in the lungs of BALB/C mice in the later stages of Chlamydia muridarum infection and reinfection}, url = {https://m2.mtmt.hu/api/publication/2465663}, author = {Mosolygó, Tímea and Spengler, Gabriella and Balogh, Emese Petra and Endrész, Valéria and Laczi, Krisztián and Perei, Katalin and Burián, Katalin}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {60}, unique-id = {2465663}, issn = {1217-8950}, year = {2013}, eissn = {1588-2640}, pages = {189-190}, orcid-numbers = {Mosolygó, Tímea/0000-0002-4499-388X; Spengler, Gabriella/0000-0001-8085-0950; Endrész, Valéria/0000-0002-9402-3857; Laczi, Krisztián/0000-0002-9399-7406; Perei, Katalin/0000-0001-8989-2284; Burián, Katalin/0000-0003-1300-2374} } @{MTMT:24452948, title = {Genetic regulation, physiology, assessment and inhibition of efflux pumps responsible for multi-drug resistant phenotypes of bacterial pathogens}, url = {https://m2.mtmt.hu/api/publication/24452948}, author = {Amaral, L and Fanning, S and Spengler, Gabriella and Rodrigues, L and Iversen, C and Martins, M and Martins, A and Viveiros, M and Couto, I}, booktitle = {Bacterial Pathogens: Virulence Mechanisms, Diagnosis and Management}, publisher = {Nova Science Publishers Inc.; Nova Publishers}, unique-id = {24452948}, year = {2012}, pages = {91-116}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2168322, title = {Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells}, url = {https://m2.mtmt.hu/api/publication/2168322}, author = {Amaral, L and Spengler, Gabriella and Martins, Ana and Armada, A and Handzlik, J and Kiec-Kononowicz, K and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {32}, unique-id = {2168322}, issn = {0250-7005}, abstract = {Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well. Control over the efflux pump that bestows multidrug resistance has been a goal of research during the past decade. As a consequence of this search for inhibitors of efflux pumps, it has been noted that many agents which affect the efflux pump system of bacteria also have similar activity against efflux pumps of drug-resistant cancer cells. This review aims to identify such agents.}, keywords = {Animals; Humans; CANCER; BACTERIA; review; human; ATP-Binding Cassette Transporters; multidrug resistance protein 1; priority journal; nonhuman; phenytoin; verapamil; unclassified drug; chlorpromazine; drug mechanism; Neoplasms; Cancer chemotherapy; hydantoins; RESERPINE; multidrug resistance; Antineoplastic Agents; ANTINEOPLASTIC ACTIVITY; antibacterial activity; anti-bacterial agents; Drug Resistance, Bacterial; structure activity relation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; phenothiazine derivative; Phenothiazines; ketone derivative; chemical modification; cancer resistance; drug potency; hydantoin derivative; thioridazine; EFFLUX PUMPS; silicon derivative; sila 421; sila 409; Inhibition of efflux pumps; 1,3 dimethyl 1,3 bis(4 fluorophenyl) 1,3 bis[3 [1 (4 butylpiperazinyl)]propyl]disiloxan; 1,3 dimethyl 1,3 bis(4 fluorophenyl) 1,3 bis(3 morpholinopropyl)disiloxan; Trifluoromethyl ketones; mc 207 110; mc 04 124; hy 84; 5 benzylhydantoin}, year = {2012}, eissn = {1791-7530}, pages = {2947-2957}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:2444054, title = {Structure, Genetic Regulation, Physiology and Function of the AcrAB-TolC Efflux Pump of Escherichia coli and Salmonella}, url = {https://m2.mtmt.hu/api/publication/2444054}, author = {Amaral, Leonard and Martins, Ana and Spengler, Gabriella and Martins, Marta and Rodrigues, Liliana and McCusker, Matthew and Ntokou, Eleni and Cerca, Pedro and Machado, Lisa and Viveiros, Miguel and Couto, Isabel and Fanning, Seamus and Kristiansen, Jette and Molnár, József}, booktitle = {Antimicrobial Drug Discovery: Emerging Strategies}, doi = {10.1079/9781845939434.0044}, unique-id = {2444054}, year = {2012}, pages = {44-61}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1879153, title = {The Activity of 16 New Hydantoin Compounds on the Intrinsic and Overexpressed Efflux Pump System of Staphylococcus aureus}, url = {https://m2.mtmt.hu/api/publication/1879153}, author = {Dymek, A and Armada, A and Handzlik, J and Viveiros, M and Spengler, Gabriella and Molnár, József and Kiec-Kononowicz, K and Amaral, L}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {26}, unique-id = {1879153}, issn = {0258-851X}, abstract = {Aim: To evaluate a new series of 16 hydantoin derivatives for activity against the intrinsic and overexpressed efflux pumps of the ATTC 25923 Staphylococcus aureus and the clinical Staphylococcus aureus HPV-107 strain, respectively. MATERIALS AND METHODS: The hydantoin compounds were evaluated for activity against the efflux pumps of the ATTC 25923 S. aureus and the clinical S. aureus HPV-107 strains by the aid of the automated ethidium bromide method. Compounds that inhibited the efflux pumps of either strain were evaluated for ability to reduce or reverse resistance of these strains to oxacillin. RESULTS: Although most of the hydantoins inhibited the efflux pumps of the ATTC strain, none reduced the resistance of this strain to oxacillin. In contrast, the inhibition of the Qac efflux pump present in HPV-107 was inhibited to some degree, by much higher concentrations of the hydantoin compounds than that needed for similar activity against the ATTC strain; only hydantoin PI8a significantly reduced the minimum inhibitory concentration of oxacillin against the HPV-107 strain. CONCLUSION: Hydantoin compound PI8a may have potential for therapy of a methicillin-resistant S. aureus infection whose multidrug-resistant phenotype is due to overexpression of an efflux pump.}, keywords = {ARTICLE; nonhuman; minimum inhibitory concentration; drug structure; oxacillin; Staphylococcus aureus; bacterial strain; Antibiotic resistance; drug activity; hydantoin derivative; Ethidium bromide; Inhibition of efflux pumps; Hydantoin derivatives; Staphylococcus aureus HPV-107; Staphylococcus aureus ATCC 25923 wild-type; Reversal of resistance to oxacillin; Qac efflux pump; Intrinsic efflux pump}, year = {2012}, eissn = {1791-7549}, pages = {223-229}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:1993467, title = {Stress response and resistance of Salmonella enterica serotype Enteritidis to the efflux pump inhibitor neuroleptic drug thioridazine}, url = {https://m2.mtmt.hu/api/publication/1993467}, author = {Spengler, Gabriella and Liliana, Rodrigues and Marta, Martins and Matthew, McCusker and Sofia, Santos Costa and Eleni, Ntokou and Szabó, Ágnes Míra and Horváth, Ádám and Varga, Zoltán Gábor and Séamus, Fanning and Molnár, József and Leonard, Amaral}, booktitle = {Clinical Microbiology and Infection}, unique-id = {1993467}, year = {2012}, pages = {307-307}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:2901846, title = {Stress response and resistance of Salmonella enterica serotype Enteritidis to the efflux pump inhibitor neuroleptic drug thioridazine}, url = {https://m2.mtmt.hu/api/publication/2901846}, author = {Spengler, Gabriella and L, Rodrigues and M, Martins and M, McCusker and S, Santos Costa and E, Ntokou and Szabó, Ágnes Míra and Horváth, Ádám and Varga, Zoltán Gábor and S, Fanning and Molnár, József and L, Amaral}, unique-id = {2901846}, year = {2012}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1894951, title = {5-Arylidene(thio)hydantoin derivatives as modulators of cancer efflux pump}, url = {https://m2.mtmt.hu/api/publication/1894951}, author = {Handzlik, J and Spengler, Gabriella and Mastek, B and Dela, A and Molnár, József and Amaral, L and Kieć-Kononowicz, K}, journal-iso = {ACTA POL PHARM}, journal = {ACTA POLONIAE PHARMACEUTICA: DRUG RESEARCH}, volume = {69}, unique-id = {1894951}, issn = {0001-6837}, keywords = {ARTICLE; MOUSE; CANCER CELLS; nonhuman; animal cell; Flow Cytometry; unclassified drug; antineoplastic agent; neoplasm; structure activity relation; cancer cell culture; drug synthesis; proton nuclear magnetic resonance; Column chromatography; hydantoin derivative; thiohydantoin derivative; 5 benzylidene 2 [4 (2 hydroxyethyl)piperazin 1 yl] 1h imidazol 4 (5h)one; 5 (4 nitrobenzylidene) 2 [4 (2 hydroxyethyl)piperazin 1 yl] 1h imidazol 4 (5h)one; 5 (4 chlorobenzylidene) 2 [4 (2 hydroxyethyl)piperazin 1 yl] 1h imidazol 4 (5h)one; 5 (3 chlorobenzylidene) 2 [4 (2 hydroxyethyl)piperazin 1 yl] 1h imidazol 4 (5h)one; 5 (2,4 dichlorobenzylidene) 2 [4 (2 hydroxyethyl)piperazin 1 yl] 1h imidazol 4 (5h)one; 5 (2 chlorobenzylidene) 2 [4 (2 hydroxyethyl)piperazin 1 yl] 1h imidazol 4 (5h)one; 2 [4 (2 hydroxyethyl)piperazin 1 yl] 5 (naphthalen 2 ylmethylene) 1h imidazol 4 (5h)one; Piperazine; P-glycoprotein (ABCB1) modulators; Arylidenethiohydantoin; Arylideneimidazolones}, year = {2012}, eissn = {2353-5288}, pages = {149-156}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1879152, title = {Activity of Fourteen New Hydantoin Compounds on the Human ABCB1 Efflux Pump}, url = {https://m2.mtmt.hu/api/publication/1879152}, author = {Martins, Ana and Dymek, A and Handzlik, J and Spengler, Gabriella and Armada, A and Molnár, József and Kiec-Kononowicz, K and Amaral, L}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {26}, unique-id = {1879152}, issn = {0258-851X}, abstract = {BACKGROUND: Multidrug resistance (MDR) is one of the major concerns in the treatment of cancer and one of the major causes of therapy failure. The overexpression of an ABC transporter, the ABCB1, is often associated with MDR in cancer. Previously it was observed that hydantoin compounds can modulate the activity of the ABCB1 pump. MATERIALS AND METHODS: Fourteen hydantoin derivatives were synthesized and studied for their capacity to increase accumulation of ethidium bromide (EB) by mouse lymphoma cancer cells that were transfected with the human ABCB1 gene and overexpress the human ABCB1 pump. RESULTS: It was observed that the accumulation of EB by the cells in the presence of four of the newly synthesized hydantoins was strongly increased. Similar but milder effects were also observed for the other seven hydantoins; the remaining three had no activity. CONCLUSION: The 14 hydantoin compounds studied belong to three different structural groups. Structure-activity relationships were studied and important molecular substituents that were possibly responsible for increased the activity of the molecules were identified. This important information may lead to the continuation of our work and to the future synthesis of more active compounds.}, keywords = {ARTICLE; MOUSE; multidrug resistance protein 1; nonhuman; animal cell; unclassified drug; protein expression; drug structure; multidrug resistance; structure activity relation; drug synthesis; drug activity; gene overexpression; cancer cell; genetic transfection; hydantoin derivative; hydantoin; lymphoma cell; ABCB1; Ethidium bromide; phenylpiperazine 5,5 dimethylhydantoin derivative; ethyl 2 [3 [2 hydroxy 3 [4 (2 hydroxyethyl)piperazin 1 yl]propyl] 2,5 dioxo 4,4 diphenylimidazolidin 1 yl]acetate; Pg-P1}, year = {2012}, eissn = {1791-7549}, pages = {293-297}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1854097, title = {Genetic response of Salmonella enterica serotype Enteritidis to thioridazine rendering the organism resistant to the agent}, url = {https://m2.mtmt.hu/api/publication/1854097}, author = {Spengler, Gabriella and Rodrigues, L and Martins, Ana and Martins, M and McCusker, M and Cerca, P and Machado, L and Costa, SS and Ntokou, E and Couto, I and Viveiros, M and Fanning, S and Molnár, József and Amaral, L}, doi = {10.1016/j.ijantimicag.2011.08.013}, journal-iso = {INT J ANTIMICROB AG}, journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS}, volume = {39}, unique-id = {1854097}, issn = {0924-8579}, year = {2012}, eissn = {1872-7913}, pages = {16-21}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822630, title = {Ethidium bromide efflux by Salmonella: modulation by metabolic energy, pH, ions and phenothiazines}, url = {https://m2.mtmt.hu/api/publication/1822630}, author = {Amaral, L and Cerca, P and Spengler, Gabriella and Machado, L and Martins, Ana and Couto, I and Viveiros, M and Fanning, S and Pages, JM}, doi = {10.1016/j.ijantimicag.2011.03.014}, journal-iso = {INT J ANTIMICROB AG}, journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS}, volume = {38}, unique-id = {1822630}, issn = {0924-8579}, year = {2011}, eissn = {1872-7913}, pages = {140-145}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1876459, title = {Prevention of VP-16 Resistance by a Disiloxane, SILA409: Effects of SILA409 on the Expression of GRP78 in NCI-H446 Human Small Cell Lung Cancer Cells}, url = {https://m2.mtmt.hu/api/publication/1876459}, author = {Li, EC and Zhang, JH and Wang, JR and Gao, F and Yang, ZH and Meng, Q and Zhang, QQ and Li, N and Huang, M and Spengler, Gabriella and Molnár, József and Wang, Q}, doi = {10.2174/157018011796575971}, journal-iso = {LETT DRUG DES DISCOV}, journal = {LETTERS IN DRUG DESIGN AND DISCOVERY}, volume = {8}, unique-id = {1876459}, issn = {1570-1808}, keywords = {INHIBITOR; APOPTOSIS; INDUCTION; CHEMOTHERAPY; ARTICLE; human; Cell Survival; Up-Regulation; comparative study; reverse transcription polymerase chain reaction; priority journal; controlled study; GLUCOSE; drug effect; Western blotting; Down-Regulation; calcium ionophore; human cell; protein blood level; unclassified drug; protein expression; messenger rna; antineoplastic agent; DRUG-RESISTANCE; multidrug resistance; calcimycin; immunofluorescence; etoposide; cisplatin; Cell viability; upregulation; down regulation; drug sensitivity; cancer resistance; cancer cell culture; IC 50; immunofluorescence test; calcium antagonist; glucose regulated protein 78; cancer cell; GRP78; lung small cell cancer; 3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide; SCLC; sila 409; hexamethyldisiloxane; 4',6 diamidino 2 phenylindole; VP-16; SILA409; Disiloxane; SILICON-COMPOUNDS}, year = {2011}, eissn = {1875-628X}, pages = {691-697}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822629, title = {Biological Activity of Twenty-three Hydantoin Derivatives on Intrinsic Efflux Pump System of Salmonella enterica serovar Enteritidis NCTC 13349}, url = {https://m2.mtmt.hu/api/publication/1822629}, author = {Machado, L and Spengler, Gabriella and Evaristo, M and Handzlik, J and Molnár, József and Viveiros, M and Kiec-Kononowicz, K and Amaral, L}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {25}, unique-id = {1822629}, issn = {0258-851X}, keywords = {INHIBITION; ARTICLE; nonhuman; Microbial Sensitivity Tests; Fluorescent Dyes; unclassified drug; hydantoins; biological activity; Salmonella enteritidis; P3; antibacterial activity; anti-bacterial agents; Membrane Transport Proteins; Bacterial Proteins; hydantoin derivative; Ethidium; EFFLUX PUMPS; Ethidium bromide; rw 15b; rw 13; pdph 3; mn 3; ll 9; kk xv; kf 2; gg 5k; bs 1; ad 29; ad 26; Salmonella enterica; Thioam 1; TD 7k; SZ7; SZ2; P7; Mor 1; JHP 1; JHF 1; JHC 2; JH 63; Fur 2; Salmonella enterica serovar enteritidis NCTC 13349; Metabolic dependent; Hydantoin compounds; Automated real-time fluorimetry}, year = {2011}, eissn = {1791-7549}, pages = {769-772}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822631, title = {Role of calcium in the efflux system of Escherichia coli}, url = {https://m2.mtmt.hu/api/publication/1822631}, author = {Martins, Ana and Machado, L and Costa, S and Cerca, P and Spengler, Gabriella and Viveiros, M and Amaral, L}, doi = {10.1016/j.ijantimicag.2011.01.010}, journal-iso = {INT J ANTIMICROB AG}, journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS}, volume = {37}, unique-id = {1822631}, issn = {0924-8579}, year = {2011}, eissn = {1872-7913}, pages = {410-414}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822633, title = {Inhibition of efflux pumps in meticillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina}, url = {https://m2.mtmt.hu/api/publication/1822633}, author = {Ramalhete, C and Spengler, Gabriella and Martins, Ana and Martins, M and Viveiros, M and Mulhovo, S and Ferreira, MJU and Amaral, L}, doi = {10.1016/j.ijantimicag.2010.09.011}, journal-iso = {INT J ANTIMICROB AG}, journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS}, volume = {37}, unique-id = {1822633}, issn = {0924-8579}, year = {2011}, eissn = {1872-7913}, pages = {70-74}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @misc{MTMT:3375000, title = {Potential cancer chemopreventive agents isolated from medicinal herbs.}, url = {https://m2.mtmt.hu/api/publication/3375000}, author = {Spengler, Gabriella and Molnár, József and Serly, Julianna and Engi, H and Hohmann, Judit and Gang, G and Ferreira, MJU and Dumache, R and Pusztai, Rozália}, unique-id = {3375000}, year = {2011}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:2405989, title = {Potential cancer chemopreventive agents isolated from medical herbs}, url = {https://m2.mtmt.hu/api/publication/2405989}, author = {Spengler, Gabriella and Molnár, József and Serly, Julianna and Engi, H and Hohmann, Judit and Gang, G and Ferreira, MJU and Dumache, R and Pusztai, Rozália}, journal-iso = {FIZIOLOGIA}, journal = {FIZIOLOGIA}, volume = {Suppl.}, unique-id = {2405989}, issn = {1223-2076}, year = {2011}, eissn = {2247-2061}, pages = {28}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:1822628, title = {Modulation of Multidrug Efflux Pump Activity by New Hydantoin Derivatives on Colon Adenocarcinoma Cells without Inducing Apoptosis}, url = {https://m2.mtmt.hu/api/publication/1822628}, author = {Spengler, Gabriella and Handzlik, J and Ocsovszki, Imre and Viveiros, M and Kiec-Kononowicz, K and Molnár, József and Amaral, L}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {31}, unique-id = {1822628}, issn = {0250-7005}, year = {2011}, eissn = {1791-7530}, pages = {3285-3288}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Ocsovszki, Imre/0000-0003-1290-996X} } @article{MTMT:1822627, title = {Thioridazine Induces Apoptosis of Multidrug-resistant Mouse Lymphoma Cells Transfected with the Human ABCB1 and Inhibits the Expression of P-Glycoprotein}, url = {https://m2.mtmt.hu/api/publication/1822627}, author = {Spengler, Gabriella and Molnár, József and Viveiros, M and Amaral, L}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {31}, unique-id = {1822627}, issn = {0250-7005}, year = {2011}, eissn = {1791-7530}, pages = {4201-4205}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1714772, title = {Quenching effect on singlet oxygen, suppression against generation of reactive oxygen species and melanin synthesis in skin, and inhibition of multidrug resistance in cancer cells by capsorubin and capsanthin}, url = {https://m2.mtmt.hu/api/publication/1714772}, author = {Yasui, H and Maoka, T and Molnár, József and Vincze, I and Molnár, Péter and Deli, József and Spengler, Gabriella and Zalatnai, A}, journal-iso = {ACTA BIOL CRACOV BOT}, journal = {ACTA BIOLOGICA CRACOVIENSIA SERIES BOTANICA}, volume = {53}, unique-id = {1714772}, issn = {0001-5296}, year = {2011}, eissn = {1898-0295}, pages = {71}, orcid-numbers = {Deli, József/0000-0002-0625-6117; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:22840041, title = {Genetic Regulation, Physiology, Assessment and Inhibition of Efflux Pumps Responsible for Multi-Drug Resistant Phenotypes of Bacterial Pathogens}, url = {https://m2.mtmt.hu/api/publication/22840041}, author = {Amaral, L and Fanning, S and McCusker, M and Spengler, Gabriella and Rodrigues, L and Iversen, C and Martins, M and Martins, A and Viveiros, M and Couto, I}, booktitle = {MULTIPLE DRUG RESISTANCE}, publisher = {Nova Science Publishers Inc.; Nova Publishers}, unique-id = {22840041}, year = {2010}, pages = {225-244}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822635, title = {Phenothiazines, Bacterial Efflux Pumps and Targeting the Macrophage for Enhanced Killing of Intracellular XDRTB}, url = {https://m2.mtmt.hu/api/publication/1822635}, author = {Amaral, L and Martins, Ana and Molnár, József and Kristiansen, JE and Martins, M and Viveiros, M and Rodrigues, L and Spengler, Gabriella and Couto, I and Ramos, J and Dastidar, S and Fanning, S and Mccusker, M and Pages, JM}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {24}, unique-id = {1822635}, issn = {0258-851X}, year = {2010}, eissn = {1791-7549}, pages = {409-424}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822634, title = {Physiological characterisation of the efflux pump system of antibiotic-susceptible and multidrug-resistant Enterobacter aerogenes}, url = {https://m2.mtmt.hu/api/publication/1822634}, author = {Martins, Ana and Spengler, Gabriella and Martins, M and Rodrigues, L and Viveiros, M and Davin-Regli, A and Chevalier, J and Couto, I and Pages, JM and Amaral, L}, doi = {10.1016/j.ijantimicag.2010.06.036}, journal-iso = {INT J ANTIMICROB AG}, journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS}, volume = {36}, unique-id = {1822634}, issn = {0924-8579}, year = {2010}, eissn = {1872-7913}, pages = {313-318}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822632, title = {Biological Activity of Hydantoin Derivatives on P-Glycoprotein (ABCB1) of Mouse Lymphoma Cells}, url = {https://m2.mtmt.hu/api/publication/1822632}, author = {Spengler, Gabriella and Evaristo, M and Handzlik, J and Serly, Julianna and Molnár, József and Viveiros, M and Kiec-Kononowicz, K and Amaral, L}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {30}, unique-id = {1822632}, issn = {0250-7005}, year = {2010}, eissn = {1791-7530}, pages = {4867-4871}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2442619, title = {Evaluation of efflux activity of bacteria by a semi-automated fluorometric system.}, url = {https://m2.mtmt.hu/api/publication/2442619}, author = {Viveiros, M and Rodrigues, L and Martins, M and Couto, I and Spengler, Gabriella and Martins, Ana and Amaral, L}, doi = {10.1007/978-1-60327-279-7_12}, journal-iso = {METHODS MOL BIOL}, journal = {METHODS IN MOLECULAR BIOLOGY}, volume = {642}, unique-id = {2442619}, issn = {1064-3745}, abstract = {A semi-automated method that uses the common efflux pump (EP) substrate ethidium bromide (EB) is described for the assessment of EP systems of bacteria. The method employs the Rotor-Gene(TM) 3000 thermocycler (Corbett Research) for the real-time assessment of accumulation and efflux of EB in Phosphate-Buffered Solution (PBS) under varying physiological conditions, such as temperature, pH, presence and absence of the energy source, and presence of efflux pumps inhibitors (EPIs). The method is sufficiently sensitive to characterize intrinsic EP systems of reference strains, a prime necessity if there is a need for assessment of EP-mediated multi-drug resistance (MDR). The method has been successfully applied by us to characterize intrinsic and over-expressed EP systems of Escherichia coli, Salmonella Enteritidis, Enterobacter aerogenes, Enterococcus faecalis and Enterococcus faecium, Staphylococcus aureus, and Mycobacterium smegmatis and Mycobacterium avium, suggesting that if the organism can be maintained in PBS, the system described may suffice for the evaluation and assessment of its EP system.}, keywords = {metabolism; ARTICLE; methodology; physiology; Biological Transport; Fluorometry; transport at the cellular level; multidrug resistance; Membrane Transport Proteins; carrier protein; Bacterial Proteins; bacterial protein; Ethidium; Drug Resistance, Multiple, Bacterial}, year = {2010}, eissn = {1940-6029}, pages = {159-172}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:2445850, title = {Genetic Regulation, Physiology, Assessment and Inhibition of Efflux Pumps Responsible for Multi-Drug Resistant Phenotypes of Bacterial Pathogens}, url = {https://m2.mtmt.hu/api/publication/2445850}, author = {Amaral, L and Fanning, S and Spengler, Gabriella and Rodrigues, L and Iversen, C and Martins, M and Martins, Ana and Viveiros, M and Couto, I}, booktitle = {Antibiotic Resistance: Causes and Risk Factors, Mechanisms and Alternatives}, unique-id = {2445850}, year = {2009}, pages = {313-332}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822637, title = {An AcrAB-mediated multidrug-resistant phenotype is maintained following restoration of wild-type activities by efflux pump genes and their regulators}, url = {https://m2.mtmt.hu/api/publication/1822637}, author = {Martins, Ana and Iversen, C and Rodrigues, L and Spengler, Gabriella and Ramos, J and Kern, WV and Couto, I and Viveiros, M and Fanning, S and Pages, JM and Amaral, L}, doi = {10.1016/j.ijantimicag.2009.06.029}, journal-iso = {INT J ANTIMICROB AG}, journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS}, volume = {34}, unique-id = {1822637}, issn = {0924-8579}, year = {2009}, eissn = {1872-7913}, pages = {602-604}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822636, title = {pH Modulation of Efflux Pump Activity of Multi-Drug Resistant Escherichia coli. Protection During Its Passage and Eventual Colonization of the Colon}, url = {https://m2.mtmt.hu/api/publication/1822636}, author = {Martins, Ana and Spengler, Gabriella and Rodrigues, L and Viveiros, M and Ramos, J and Martins, M and Couto, I and Fanning, S and Pages, JM and Bolla, JM and Molnár, József and Amaral, L}, doi = {10.1371/journal.pone.0006656}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {4}, unique-id = {1822636}, issn = {1932-6203}, keywords = {Hydrogen-Ion Concentration; Biological Transport; Microbial Sensitivity Tests; Escherichia coli/growth & development/*metabolism; *Drug Resistance, Multiple; Colon/*microbiology}, year = {2009}, eissn = {1932-6203}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822639, title = {Efflux modulators from Momordica balsamina L. in multidrug resistant bacterial strains}, url = {https://m2.mtmt.hu/api/publication/1822639}, author = {Ramalhete, C and Spengler, Gabriella and Serly, Julianna and Amaral, L and Molnár, József and Mulhovo, S and Ferreira, MJU}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {75}, unique-id = {1822639}, issn = {0032-0943}, year = {2009}, eissn = {1439-0221}, pages = {896-896}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822641, title = {Characterization of Intrinsic Efflux Activity of Enterococcus faecalis ATCC29212 by a Semi-automated Ethidium Bromide Method}, url = {https://m2.mtmt.hu/api/publication/1822641}, author = {Spengler, Gabriella and Martins, Ana and Schelz, Zsuzsanna and Rodrigues, L and Aagaard, L and Martins, M and Costa, SS and Couto, I and Viveiros, M and Fanning, S and Kristiansen, JE and Molnár, József and Amaral, L}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {23}, unique-id = {1822641}, issn = {0258-851X}, year = {2009}, eissn = {1791-7549}, pages = {81-87}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Schelz, Zsuzsanna/0000-0002-8519-4830} } @article{MTMT:1822640, title = {Demonstration of the Activity of P-glycoprotein by a Semi-automated Fluorometric Method}, url = {https://m2.mtmt.hu/api/publication/1822640}, author = {Spengler, Gabriella and Viveiros, M and Martins, M and Rodrigues, L and Martins, Ana and Molnár, József and Couto, I and Amaral, L}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {29}, unique-id = {1822640}, issn = {0250-7005}, year = {2009}, eissn = {1791-7530}, pages = {2173-2177}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822638, title = {Evaluation of Cucurbitane-type Triterpenoids from Momordica balsamina on P-Glycoprotein (ABCB1) by Flow Cytometry and Real-time Fluorometry}, url = {https://m2.mtmt.hu/api/publication/1822638}, author = {Spengler, Gabriella and Ramalhete, C and Martins, M and Martins, Ana and Serly, Julianna and Viveiros, M and Molnár, József and Duarte, N and Mulhovo, S and Ferreira, MJU and Amaral, L}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {29}, unique-id = {1822638}, issn = {0250-7005}, year = {2009}, eissn = {1791-7530}, pages = {3989-3993}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822642, title = {ASSESSMENT AND COMPARISON OF EFFLUX PUMPS OF CANCER CELLS AND MDR BACTERIA UNDER PHYSIOLOGICAL CONDITIONS BY A REAL-TIME SEMI-AUTOMATED SYSTEM}, url = {https://m2.mtmt.hu/api/publication/1822642}, author = {Amaral, L and Spengler, Gabriella and Viveiros, M and Rodrigues, L and Martins, Ana and Couto, I and Martins, M and Fanning, S and Pages, JM and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {28}, unique-id = {1822642}, issn = {0250-7005}, year = {2008}, eissn = {1791-7530}, pages = {3193-3194}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822643, title = {CONSTITUENTS OF CARPOBROTUS EDULIS INHIBIT P-GLYCOPROTEIN OF HUMAN MDR1 GENE TRANSFECTED MOUSE LYMPHOMA CELLS}, url = {https://m2.mtmt.hu/api/publication/1822643}, author = {Martins, Ana and Vasas, Andrea and Schelz, Zsuzsanna and Viveiros, M and Molnár, József and Hohmann, Judit and Spengler, Gabriella and Amaral, L}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {28}, unique-id = {1822643}, issn = {0250-7005}, year = {2008}, eissn = {1791-7530}, pages = {3397-3397}, orcid-numbers = {Vasas, Andrea/0000-0002-1818-7702; Schelz, Zsuzsanna/0000-0002-8519-4830; Hohmann, Judit/0000-0002-2887-6392; Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822646, title = {Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections: mechanisms for their direct and indirect activities}, url = {https://m2.mtmt.hu/api/publication/1822646}, author = {Martins, M and Dastidar, SG and Fanning, S and Kristiansen, JE and Molnár, József and Pages, JM and Schelz, Zsuzsanna and Spengler, Gabriella and Viveiros, M and Amaral, L}, doi = {10.1016/j.ijantimicag.2007.10.025}, journal-iso = {INT J ANTIMICROB AG}, journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS}, volume = {31}, unique-id = {1822646}, issn = {0924-8579}, year = {2008}, eissn = {1872-7913}, pages = {198-208}, orcid-numbers = {Schelz, Zsuzsanna/0000-0002-8519-4830; Spengler, Gabriella/0000-0001-8085-0950} } @{MTMT:1140757, title = {Multidrug Resistance Reversal on Cancer Cells by Selected Carotenoids, Flavonoids and Anthocyanins}, url = {https://m2.mtmt.hu/api/publication/1140757}, author = {Molnár, József and Engi, Helga and Gyémánt, N and Schelz, Zsuzsanna and Spengler, Gabriella and Ocsovszki, Imre and Szücs, M and Hohmann, Judit and Szabó, M and Tanács, Lajos and Molnár, Péter and Deli, József and Krenn, L and Kawase, M and Wakabayashi, H and Kurihara, T and Shirataki, Y and Sakagami, H and Motohashi, N and Didiziapetris, R}, booktitle = {Bioactive Heterocycles VI}, doi = {10.1007/7081_2008_120}, unique-id = {1140757}, year = {2008}, pages = {133-159}, orcid-numbers = {Schelz, Zsuzsanna/0000-0002-8519-4830; Spengler, Gabriella/0000-0001-8085-0950; Ocsovszki, Imre/0000-0003-1290-996X; Hohmann, Judit/0000-0002-2887-6392; Deli, József/0000-0002-0625-6117} } @article{MTMT:2756099, title = {DEMONSTRATION OF THE ACTIVITY OF P-GLYCOPROTEIN BY A FULLY AUTOMATED ETHIDIUM BROMIDE METHOD}, url = {https://m2.mtmt.hu/api/publication/2756099}, author = {Spengler, Gabriella and Viveiros, M and Martins, A and Rodrigues, L and Martins, M and Molnár, József and Couto, I and Amaral, L}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {28}, unique-id = {2756099}, issn = {0250-7005}, year = {2008}, eissn = {1791-7530}, pages = {3493-3493}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822645, title = {New Methods for the Identification of Efflux Mediated MDR Bacteria, Genetic Assessment of Regulators and Efflux Pump Constituents, Characterization of Efflux Systems and Screening for Inhibitors of Efflux Pumps}, url = {https://m2.mtmt.hu/api/publication/1822645}, author = {Viveiros, M and Martins, M and Couto, I and Rodrigues, L and Spengler, Gabriella and Martins, Ana and Kristiansen, JE and Molnár, József and Amaral, L}, doi = {10.2174/138945008785747734}, journal-iso = {CURR DRUG TARGETS}, journal = {CURRENT DRUG TARGETS}, volume = {9}, unique-id = {1822645}, issn = {1389-4501}, year = {2008}, eissn = {1873-5592}, pages = {760-778}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:3241008, title = {Attempts to Reduce Drug Resistance of Bacteria and Cancer Cells [PhD Thesis]}, url = {https://m2.mtmt.hu/api/publication/3241008}, author = {Spengler, Gabriella}, doi = {10.1556/OH-HMJ.2007.28016}, journal-iso = {HUNG MED J}, journal = {HUNGARIAN MEDICAL JOURNAL}, volume = {1}, unique-id = {3241008}, issn = {1788-6139}, year = {2007}, pages = {109-125}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822543, title = {Kísérletek baktériumok és tumorsejtek gyógyszer-rezisztenciájának csökkentésére [Attempts to reduce drug resistance of bacteria and cancer cells]}, url = {https://m2.mtmt.hu/api/publication/1822543}, author = {Spengler, Gabriella}, doi = {10.1556/OH.2007.28016}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {148}, unique-id = {1822543}, issn = {0030-6002}, year = {2007}, eissn = {1788-6120}, pages = {1037-1040}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822649, title = {Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells}, url = {https://m2.mtmt.hu/api/publication/1822649}, author = {Baráth, Zoltán Lajos and Radics, R and Spengler, Gabriella and Ocsovszki, Imre and Kawase, M and Motohashi, N and Shirataki, Y and Shah, A and Molnár, József}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {20}, unique-id = {1822649}, issn = {0258-851X}, year = {2006}, eissn = {1791-7549}, pages = {645-649}, orcid-numbers = {Baráth, Zoltán Lajos/0000-0003-0636-6313; Spengler, Gabriella/0000-0001-8085-0950; Ocsovszki, Imre/0000-0003-1290-996X} } @article{MTMT:1822648, title = {Ultrasound absorption and entropy production in biological tissue: a novel approach to anticancer therapy}, url = {https://m2.mtmt.hu/api/publication/1822648}, author = {Luo, LF and Molnár, József and Ding, H and Lv, XG and Spengler, Gabriella}, doi = {10.1186/1746-1596-1-35}, journal-iso = {DIAGN PATHOL}, journal = {DIAGNOSTIC PATHOLOGY}, volume = {1}, unique-id = {1822648}, issn = {1746-1596}, year = {2006}, eissn = {1746-1596}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822647, title = {Physicochemical attack against solid tumors based on the reversal of direction of entropy flow: an attempt to introduce thermodynamics in anticancer therapy}, url = {https://m2.mtmt.hu/api/publication/1822647}, author = {Luo, LF and Molnár, József and Ding, H and Lv, XG and Spengler, Gabriella}, doi = {10.1186/1746-1596-1-43}, journal-iso = {DIAGN PATHOL}, journal = {DIAGNOSTIC PATHOLOGY}, volume = {1}, unique-id = {1822647}, issn = {1746-1596}, year = {2006}, eissn = {1746-1596}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @CONFERENCE{MTMT:2121384, title = {Reversal of Resistance of Cancer Cells by Inhibition of Efflux Pump}, url = {https://m2.mtmt.hu/api/publication/2121384}, author = {Molnár, J and Demirel-Kars, M and Engi, H and Spengler, Gabriella and Gyémánt, N and Molnár, Péter and Schuhmacher, U and Makoviczky, J}, booktitle = {János Fischer Memorial Symposium, Biological Research Center of the Hungarian Academy of Sciences}, unique-id = {2121384}, year = {2006}, pages = {13}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822650, title = {The mechanism of plasmid curing in bacteria}, url = {https://m2.mtmt.hu/api/publication/1822650}, author = {Spengler, Gabriella and Molnár, Annamária and Schelz, Zsuzsanna and Amaral, L and Sharples, D and Molnár, József}, doi = {10.2174/138945006777709601}, journal-iso = {CURR DRUG TARGETS}, journal = {CURRENT DRUG TARGETS}, volume = {7}, unique-id = {1822650}, issn = {1389-4501}, year = {2006}, eissn = {1873-5592}, pages = {823-841}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Schelz, Zsuzsanna/0000-0002-8519-4830} } @mastersthesis{MTMT:2241107, title = {Attempts to reduce drug resistance of bacteria and cancer cells}, url = {https://m2.mtmt.hu/api/publication/2241107}, author = {Spengler, Gabriella}, publisher = {SZTE}, unique-id = {2241107}, year = {2006}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822651, title = {Synergistic interaction between proton pump inhibitors and resistance modifiers: Promoting effects of antibiotics and plasmid curing}, url = {https://m2.mtmt.hu/api/publication/1822651}, author = {Wolfart, K and Spengler, Gabriella and Kawase, M and Motohashi, N and Molnár, József and Viveiros, M and Amaral, L}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {20}, unique-id = {1822651}, issn = {0258-851X}, year = {2006}, eissn = {1791-7549}, pages = {367-372}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822653, title = {Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity}, url = {https://m2.mtmt.hu/api/publication/1822653}, author = {Kawase, M and Sakagami, H and Motohashi, N and Hauer, H and Chatterjee, SS and Spengler, Gabriella and Vigyikanne, AV and Molnár, Annamária and Molnár, József}, journal-iso = {IN VIVO}, journal = {IN VIVO}, volume = {19}, unique-id = {1822653}, issn = {0258-851X}, year = {2005}, eissn = {1791-7549}, pages = {705-711}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:2738424, title = {Erratum: The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA (European Journal of Medicinal Chemistry (2005) 40 (195-202) DOI: 10.1016/j.ejmech.2004.10.011)}, url = {https://m2.mtmt.hu/api/publication/2738424}, author = {Sharples, D and Spengler, Gabriella and Molnár, József and Antal, Z and Molnár, A and Kiss T., János and Szabó, JA and Hilgeroth, A and Gallo, S and Mahamoud, A and Barbe, J}, doi = {10.1016/j.ejmech.2005.04.001}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {40}, unique-id = {2738424}, issn = {0223-5234}, keywords = {erratum; retracted article}, year = {2005}, eissn = {1768-3254}, pages = {1070}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:247310, title = {The interaction between resistance modifiers such as pyrido[3,2-g]quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA.}, url = {https://m2.mtmt.hu/api/publication/247310}, author = {Sharples, D and Spengler, Gabriella and Molnár, József and Antal, Zsuzsanna and Molnár, Annamária and Kiss T., János and Szabó, JA and Hilgeroth, A and Gallo, S and Mahamoud, A and Barbe, JB}, doi = {10.1016/j.ejmech.2004.10.011}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {40}, unique-id = {247310}, issn = {0223-5234}, year = {2005}, eissn = {1768-3254}, pages = {195-202}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1915151, title = {Bacterial models for tumor development}, url = {https://m2.mtmt.hu/api/publication/1915151}, author = {Gyemant, N and Molnár, Annamária and Spengler, Gabriella and Mándi, Yvette and Szabo, M and Molnár, József}, doi = {10.1556/AMicr.51.2004.3.10}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {51}, unique-id = {1915151}, issn = {1217-8950}, year = {2004}, eissn = {1588-2640}, pages = {321-332}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Mándi, Yvette/0000-0003-4729-2445} } @article{MTMT:1822656, title = {Effect of cycloartanes on reversal of multidrug resistance and apoptosis induction on mouse lymphoma cells}, url = {https://m2.mtmt.hu/api/publication/1822656}, author = {Madureira, AM and Spengler, Gabriella and Molnár, Annamária and Varga, A and Molnár, József and Abreu, PM and Ferreira, MJU}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {24}, unique-id = {1822656}, issn = {0250-7005}, year = {2004}, eissn = {1791-7530}, pages = {859-864}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1915152, title = {Infectious plasmid resistance and efflux pump mediated resistance}, url = {https://m2.mtmt.hu/api/publication/1915152}, author = {Molnár, József and Molnár, Annamária and Spengler, Gabriella and Mándi, Yvette}, doi = {10.1556/AMicr.51.2004.3.11}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {51}, unique-id = {1915152}, issn = {1217-8950}, year = {2004}, eissn = {1588-2640}, pages = {333-349}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Mándi, Yvette/0000-0003-4729-2445} } @article{MTMT:1822657, title = {Biological activity of Barbados cherry (Acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions}, url = {https://m2.mtmt.hu/api/publication/1822657}, author = {Motohashi, N and Wakabayashi, H and Kurihara, T and Fukushima, H and Yamada, T and Kawase, M and Sohara, Y and Tani, S and Shirataki, Y and Sakagami, H and Satoh, K and Nakashima, H and Molnár, Annamária and Spengler, Gabriella and Gyemant, N and Ugocsai, Katalin and Molnár, József}, doi = {10.1002/ptr.1426}, journal-iso = {PHYTOTHER RES}, journal = {PHYTOTHERAPY RESEARCH}, volume = {18}, unique-id = {1822657}, issn = {0951-418X}, year = {2004}, eissn = {1099-1573}, pages = {212-223}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822655, title = {BIOLOGICAL ACTIVITY OF BARBADOS CHERRY (ACEROLA FRUITS, FRUIT OF MALPIGHIA EMARGINATA DC.) EXTRACTS AND FRACTIONS}, url = {https://m2.mtmt.hu/api/publication/1822655}, author = {Motohashi, N and Wakabayashi, H and Kurihara, T and Fukushima, H and Yamada, T and Kawase, M and Sohara, Y and Tani, S and Shirataki, Y and Sakagam, H and Satoh, K and Nakashima, H and Molnar, A and Spengler, Gabriella and Gyemant, N and Ugocsai, Katalin and Molnár, József}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {24}, unique-id = {1822655}, issn = {0250-7005}, year = {2004}, eissn = {1791-7530}, pages = {3569-3570}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1359982, title = {The antimotility action of trifluoromethyl ketone on some Gram-negative bacteria}, url = {https://m2.mtmt.hu/api/publication/1359982}, author = {Spengler, Gabriella and Molnár, Annamária and Klausz, Gergely and Mándi, Yvette and Kawase, N and Motohashi, N and Molnár, József}, doi = {10.1556/AMicr.51.2004.3.12}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {51}, unique-id = {1359982}, issn = {1217-8950}, year = {2004}, eissn = {1588-2640}, pages = {351-358}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Mándi, Yvette/0000-0003-4729-2445} } @CONFERENCE{MTMT:1158127, title = {Plasmid elimination and antimotility studies in the presence of a trifluoroketone proton pump inhibitor on Escherichia coli and Helicobacter pylori strains}, url = {https://m2.mtmt.hu/api/publication/1158127}, author = {Spengler, Gabriella and Molnar, A and Klausz, Gergely and Mándi, Yvette and Kawase, M and Amaral, L and Molnár, József}, booktitle = {6th European Congress of Chemotherapy and Infection, 24th Interdisciplinary Meeting Chemotherapy Anti-infections}, unique-id = {1158127}, year = {2004}, pages = {S199-S199}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Mándi, Yvette/0000-0003-4729-2445} } @article{MTMT:1158125, title = {Inhibitory action of a new proton pump inhibitor, trifluoromethyl ketone derivative, against the motility of clarithromycin-susceptible and-resistant Helicobacter pylori}, url = {https://m2.mtmt.hu/api/publication/1158125}, author = {Spengler, Gabriella and Molnár, Annamária and Klausz, Gergely and Mándi, Yvette and Kawase, M and Motohashi, N and Molnár, József}, doi = {10.1016/j.ijantimicag.2003.11.010}, journal-iso = {INT J ANTIMICROB AG}, journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS}, volume = {23}, unique-id = {1158125}, issn = {0924-8579}, abstract = {In the process of endourological development a variety of foreign bodies have been invented besides urinary catheters, on which biofilm can be formed. Bacteria in the biofilm are less susceptible to antibiotics. An additional problem of medical biomaterials in the urinary tract environment is the development of encrustation and consecutive obstruction. The most promising prevention strategy for bacterial biofilms is the production of materials with anti-adhesive surfaces such as heparin. Although heparin-coated ureteral stents are expensive, they justify their cost. Our studies show that such devices are protected against incrustation and biofilm formation for a longer period of time: 6-12 months, both in vitro and in vivo. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.}, year = {2004}, eissn = {1872-7913}, pages = {631-633}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Mándi, Yvette/0000-0003-4729-2445} } @article{MTMT:1822659, title = {Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells}, url = {https://m2.mtmt.hu/api/publication/1822659}, author = {Alibert, S and Santelli-Rouvier, C and Castaing, M and Berthlot, M and Spengler, Gabriella and Molnár, József and Barbe, J}, doi = {10.1016/S0223-5234(03)00018-7}, journal-iso = {EUR J MED CHEM}, journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, volume = {38}, unique-id = {1822659}, issn = {0223-5234}, year = {2003}, eissn = {1768-3254}, pages = {253-263}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822658, title = {Biological activity of persimmon (Diospyros kaki) peel extracts}, url = {https://m2.mtmt.hu/api/publication/1822658}, author = {Kawase, M and Motohashi, N and Satoh, K and Sakagami, H and Nakashima, H and Tani, S and Shirataki, Y and Kurihara, T and Spengler, Gabriella and Wolfard, K and Molnár, József}, doi = {10.1002/ptr.1183}, journal-iso = {PHYTOTHER RES}, journal = {PHYTOTHERAPY RESEARCH}, volume = {17}, unique-id = {1822658}, issn = {0951-418X}, year = {2003}, eissn = {1099-1573}, pages = {495-500}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1351209, title = {Enhancement of plasmid curing by 9-aminoacridine and two phenothiazines in the presence of proton pump inhibitor 1-(2-benzoxazolyl)-3,3,3-trifluoro-2-propanone}, url = {https://m2.mtmt.hu/api/publication/1351209}, author = {Spengler, Gabriella and Miczák, András and Hajdú, Edit and Kawase, M and Amaral, L and Molnár, József}, doi = {10.1016/S0924-8579(03)00207-3}, journal-iso = {INT J ANTIMICROB AG}, journal = {INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS}, volume = {22}, unique-id = {1351209}, issn = {0924-8579}, abstract = {Plasmid-containing bacteria often cause serious therapeutic failure during the treatment of infectious diseases. The selection of resistant-mutant strains and the transfer of mobile genetic determinants (such as plasmids and transposons) of resistance promote increased antibiotic resistance. In the last 30 years the antiplasmid effect of acridine dyes, ethidium bromide, sodium dodecyl sulphate and phenothiazines was described. The main aim of this study was to test the mechanism of the antiplasmid effect of promethazine and 9-aminoacridine on doxycycline-resistant enteric bacteria. The antiplasmid effects of promethazine and 9-aminoacridine were studied on plasmid elimination of native plasmid DNA and plasmid DNA isolated from drug-treated cells of plasmid-containing Escherichia coli, Citrobacter freundii and Enterobacter cloacae. The effects of some phenothiazines on plasmid profiles of bacterial strains isolated from urinary tract infections were analysed by agarose gel electrophoresis. Various complex of plasmid DNA were identified in the presence of promethazine, trifluoperazine and 9-aminoacridine in the agarose gel electrophoresis. Doxycycline resistance of tested enteric bacteria was the target of 'curing' in the presence of promethazine and trifluoperazine. The frequency of elimination of tetracycline resistance was low despite the formation of antiplasmid compounds complex with isolated plasmid DNA. Tetracycline resistance plasmid was isolated and re-transformed. The plasmid curing effects of promethazine, trifluoperazine and 9-aminoacridine were increased in the presence of a trifluoroketone proton pump inhibitor on E. coli K12 LE140 strain in a model experiment. We propose that the inefficient penetration of antiplasmid compounds could be responsible for the weak plasmid-curing effect in some clinical isolates and that membrane active, calmodulin- and proton pump inhibitors may be combined for plasmid curing in antibiotic-resistant bacteria. © 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.}, year = {2003}, eissn = {1872-7913}, pages = {223-227}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} } @article{MTMT:1822660, title = {Benzo[b]-1,8-naphthyridine derivatives: Synthesis and reversal activity on multidrug resistance}, url = {https://m2.mtmt.hu/api/publication/1822660}, author = {Misbahi, H and Brouant, P and Hever, Anikó and Molnár, Annamária and Wolfard, Krisztina and Spengler, Gabriella and Mefetah, H and Molnár, József and Barbe, J}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {22}, unique-id = {1822660}, issn = {0250-7005}, year = {2002}, eissn = {1791-7530}, pages = {2097-2101}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950} }