@article{MTMT:34177727,
	title = {Abnormal basement membrane results in increased keratinocyte-derived periostin expression in psoriasis similar to wound healing},
	url = {https://m2.mtmt.hu/api/publication/34177727},
	author = {Flink, Lili Borbála and Ghaffarinia, Ameneh and Papp, Benjamin Tamás and Varga, Ákos and Vigh, András István and Vidács, Dániel László and Kui, Róbert and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna and Bozó, Renáta},
	doi = {10.1038/s41598-023-43396-0},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34177727},
	issn = {2045-2322},
	abstract = {The psoriatic skin resembles wound healing, and it shows abnormalities at the basement membrane (BM), also in the non-lesional skin. Fibroblast-derived dermal periostin has well-known functions in wound healing and Th2-mediated diseases, such as atopic dermatitis. Here we show that serum periostin level was elevated in psoriatic patients, remarkably in the systemically treated ones. Obvious periostin positivity was detected in basal keratinocytes of the non-lesional, lesional, and previously-lesional psoriatic vs. healthy skin. Ex vivo skin models were generated to examine how different skin injuries affect periostin expression during wound healing. Our newly developed cultured salt-split model demonstrated that BM-injury induced periostin expression in basal keratinocytes, and periostin levels in the supernatant were also increased upon healing. In wound healing models, β1-integrin expression was similarly induced. β1-integrin blocking caused reduced periostin expression in in vitro scratch assay, indicating that β1-integrin can mediate periostin production. In contrast to atopic dermatitis, psoriatic basal keratinocytes are in an activated state and show a stable wound healing-like phenotype with the overexpression of periostin. This abnormal BM-induced wound healing as a potential compensatory mechanism can be initiated already in the non-lesional skin present in the lesion and keratinocytes can remain activated in the healed skin.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Kui, Róbert/0000-0002-9448-4573; Kemény, Lajos/0000-0002-2119-9501; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Bozó, Renáta/0000-0003-4242-2474}
}

@article{MTMT:34478779,
	title = {The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo},
	url = {https://m2.mtmt.hu/api/publication/34478779},
	author = {Hernández-Quiles, Miguel and Martinez Campesino, Laura and Morris, Imogen and Ilyas, Zabran and Reynolds, Steve and Soon Tan, Nguan and Sobrevals Alcaraz, Paula and Stigter, Edwin C.A. and Varga, Ákos and Varga, János and van Es, Robert and Vos, Harmjan and Wilson, Heather L. and Kiss-Toth, Endre and Kalkhoven, Eric},
	doi = {10.1016/j.molmet.2023.101829},
	journal-iso = {MOL METAB},
	journal = {MOLECULAR METABOLISM},
	volume = {78},
	unique-id = {34478779},
	issn = {2212-8778},
	year = {2023},
	eissn = {2212-8778},
	orcid-numbers = {Kalkhoven, Eric/0000-0002-9713-7286}
}

@article{MTMT:34085614,
	title = {Herpes Simplex Virus Infection Alters the Immunological Properties of Adipose-Tissue-Derived Mesenchymal-Stem Cells},
	url = {https://m2.mtmt.hu/api/publication/34085614},
	author = {Kun-Varga, Anikó and Konczné Gubán, Barbara and Miklós, Vanda and Parvaneh, Shahram and Guba, Melinda and Szűcs, Diána and Monostori, Tamás and Varga, János and Varga, Ákos and Rázga, Zsolt and Csörgő Sándorné Bata, Zsuzsanna and Kemény, Lajos and Megyeri, Klára and Veréb, Zoltán},
	doi = {10.3390/ijms241511989},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34085614},
	issn = {1661-6596},
	abstract = {The proper functioning of mesenchymal stem cells (MSCs) is of paramount importance for the homeostasis of the body. Inflammation and infection can alter the function of MSCs, which can also affect the regenerative potential and immunological status of tissues. It is not known whether human herpes simplex viruses 1 and 2 (HSV1 and HSV2), well-known human pathogens that can cause lifelong infections, can induce changes in MSCs. In non-healing ulcers, HSV infection is known to affect deeper tissue layers. In addition, HSV infection can recur after initially successful cell therapies. Our aim was to study the response of adipose-derived MSCs (ADMSCs) to HSV infection in vitro. After confirming the phenotype and differentiation capacity of the isolated cells, we infected the cells in vitro with HSV1-KOS, HSV1-532 and HSV2 virus strains. Twenty-four hours after infection, we examined the gene expression of the cells via RNA-seq and RT-PCR; detected secreted cytokines via protein array; and determined autophagy via Western blot, transmission electron microscopy (TEM) and fluorescence microscopy. Infection with different HSV strains resulted in different gene-expression patterns. In addition to the activation of pathways characteristic of viral infections, distinct non-immunological pathways (autophagy, tissue regeneration and differentiation) were also activated according to analyses with QIAGEN Ingenuity Pathway Analysis, Kyoto Encyclopedia of Genes and Genome and Genome Ontology Enrichment. Viral infections increased autophagy, as confirmed via TEM image analysis, and also increased levels of the microtubule-associated protein light chain 3 (LC3B) II protein. We identified significantly altered accumulation for 16 cytokines involved in tissue regeneration and inflammation. Our studies demonstrated that HSV infection can alter the viability and immunological status of ADMSCs, which may have implications for ADMSC-based cell therapies. Alterations in autophagy can affect numerous processes in MSCs, including the inhibition of tissue regeneration as well as pathological differentiation.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Rázga, Zsolt/0000-0003-4717-8482; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Kemény, Lajos/0000-0002-2119-9501; Veréb, Zoltán/0000-0002-9518-2155}
}

@article{MTMT:34443653,
	title = {Elevated serum gastrin is associated with melanoma progression: putative role in increased migration and invasion of melanoma cells},
	url = {https://m2.mtmt.hu/api/publication/34443653},
	author = {Varga, Ákos and Németh, István Balázs and Kemény, Lajos and Varga, János and Tiszlavicz, László and Kumar, D. and Dodd, S. and Simpson, A.W.M. and Buknicz, Tünde and Beynon, R. and Simpson, D. and Krenács, Tibor and Dockray, G.J. and Varro, A.},
	doi = {10.3390/ijms242316851},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34443653},
	issn = {1661-6596},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Kemény, Lajos/0000-0002-2119-9501; Tiszlavicz, László/0000-0003-1134-6587; Krenács, Tibor/0000-0001-9164-065X}
}

@article{MTMT:33928935,
	title = {Az SZTE Bőrgyógyászati és Allergológiai Klinikán a melanoma malignum sebészi kezelésében történt változások az elmúlt évtizedben [Changes in the surgical treatment of melanoma malignum at the Department of Dermatology and Allergology University of Szeged over the last decade]},
	url = {https://m2.mtmt.hu/api/publication/33928935},
	author = {Varga, Ákos and Bende, Balázs and Baltás, Eszter and Németh, István Balázs and Varga, Erika and Vass, Gábor and Kis, Erika and Oláh, Judit Magdolna and Varga, János and Kocsis, Ádám László},
	doi = {10.7188/bvsz.2023.99.2.6},
	journal-iso = {BVSZ},
	journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE},
	volume = {99},
	unique-id = {33928935},
	issn = {0006-7768},
	year = {2023},
	eissn = {2064-261X},
	pages = {122-124},
	orcid-numbers = {Baltás, Eszter/0000-0003-0357-7393; Vass, Gábor/0000-0003-0787-8679}
}

@article{MTMT:33190247,
	title = {SVF cell therapy for the treatment of non-healing limb ulcers},
	url = {https://m2.mtmt.hu/api/publication/33190247},
	author = {Bende, Balázs and Degovics, Döníz and Varga, János and Varga, Ákos and Kocsis, Ádám László and Kis, Erika and Guba, Melinda and Szűcs, Diána and Monostori, Tamás and Kemény, Lajos and Veréb, Zoltán},
	journal-iso = {BVSZ},
	journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE},
	volume = {98},
	unique-id = {33190247},
	issn = {0006-7768},
	year = {2022},
	eissn = {2064-261X},
	pages = {179-180},
	orcid-numbers = {Kemény, Lajos/0000-0002-2119-9501; Veréb, Zoltán/0000-0002-9518-2155}
}

@article{MTMT:33261241,
	title = {The potential role of periostin in psoriasis},
	url = {https://m2.mtmt.hu/api/publication/33261241},
	author = {Flink, Lili Borbála and Bozó, Renáta and Ghaffarinia, Ameneh and Papp, Benjamin Tamás and Varga, Ákos and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna},
	doi = {10.1016/j.jid.2022.09.409},
	journal-iso = {J INVEST DERMATOL},
	journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
	volume = {142},
	unique-id = {33261241},
	issn = {0022-202X},
	year = {2022},
	eissn = {1523-1747},
	pages = {S248-S248},
	orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Kemény, Lajos/0000-0002-2119-9501; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743}
}

@article{MTMT:33190341,
	title = {A periostin lehetséges szerepe a pikkelysömör patogenezisében},
	url = {https://m2.mtmt.hu/api/publication/33190341},
	author = {Flink, Lili Borbála and Ghaffarinia, Ameneh and Papp, Benjamin Tamás and Varga, Ákos and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna and Bozó, Renáta},
	journal-iso = {IMMUNOLÓGIAI SZEMLE},
	journal = {IMMUNOLÓGIAI SZEMLE},
	volume = {14},
	unique-id = {33190341},
	issn = {2061-0203},
	year = {2022},
	pages = {29-29},
	orcid-numbers = {Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Bozó, Renáta/0000-0003-4242-2474}
}

@article{MTMT:33190052,
	title = {The potential role of periostin in the pathogenesis of psoriasis},
	url = {https://m2.mtmt.hu/api/publication/33190052},
	author = {Flink, Lili Borbála and Bozó, Renáta and Ghaffarinia, Ameneh and Papp, Benjamin Tamás and Varga, Ákos and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna},
	journal-iso = {BVSZ},
	journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE},
	volume = {98},
	unique-id = {33190052},
	issn = {0006-7768},
	year = {2022},
	eissn = {2064-261X},
	pages = {176-176},
	orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743}
}

@article{MTMT:31067970,
	title = {Is it Necessary to Perform Sentinel Lymph Node Biopsy in Thin Melanoma?. A Retrospective Single Center Analysis},
	url = {https://m2.mtmt.hu/api/publication/31067970},
	author = {Kocsis, Ádám László and Karsko, L and Kurgyis, Zsuzsanna and Besenyi, Zsuzsanna and Pávics, László and Viharosné Dósa-Rácz, Éva and Kis, Erika and Baltás, Eszter and Ócsai, Henriette and Varga, Erika and Bende, Balázs and Varga, Ákos and Mohos, Gábor and Korom, Irma and Varga, János and Kemény, Lajos and Németh, István Balázs and Oláh, Judit Magdolna},
	doi = {10.1007/s12253-019-00769-z},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {26},
	unique-id = {31067970},
	issn = {1219-4956},
	abstract = {Sentinel lymph node biopsy (SLNB) is a standard procedure for regional lymph node staging and still has the most important prognostic value for the outcome of patients with thin melanoma. In addition to ulceration, SLNB had to be considered even for a single mitotic figure in thin (<1 mm) melanoma according to AJCC7th guideline, therefore, a retrospective review was conducted involving 403 pT1 melanoma patients. Among them, 152 patients suffered from pT1b ulcerated or mitotic rate ≥ 1/ mm2 melanomas according to the AJCC7th staging system. SLNB was performed in 78 cases, of which nine (11.5%) showed SLN positivity. From them, interestingly, we found a relatively high positive sentinel rate (6/78-8%) in the case of thin primary melanomas ˂0.8 mm. Moreover, the presence of regression increased the probability of sentinel positivity by 5.796 fold. After reassessing pT stage based on the new AJCC8th, 37 pT1b cases were reordered into pT1a category. There was no significant relation between other characteristics examined (age, gender, Breslow, Clark level, and mitosis index) and sentinel node positivity. Based on our data, we suggest that mitotic rate alone is not a sufficiently powerful predictor of SLN status in thin melanomas. If strict histopathological definition criteria are applied, regression might be an additional adverse feature that aids in identifying T1 patients most likely to be SLN-positive. After reassessing of pT1b cases according to AJCC8th regression proved to be independent prognostic factor on sentinel lymph node positivity. Our results propose that sentinel lymph node biopsy might also be considered at patients with regressive thin (˂0.8 mm) melanomas.},
	keywords = {STAGE; Regression; Melanoma; Sentinel Lymph Node Biopsy; Mitotic rate},
	year = {2020},
	eissn = {1532-2807},
	pages = {1861-1868},
	orcid-numbers = {Besenyi, Zsuzsanna/0000-0001-9115-9620; Pávics, László/0000-0002-7319-1667; Baltás, Eszter/0000-0003-0357-7393; Kemény, Lajos/0000-0002-2119-9501}
}