@article{MTMT:34633388,
	title = {Monitoring galactolipid digestion and simultaneous changes in lipid-bile salt micellar organization by real-time NMR spectroscopy},
	url = {https://m2.mtmt.hu/api/publication/34633388},
	author = {Sahaka, M and Bornet, O and Marchand, A and Lafont, D and Gontero, B and Carrière, F and Launay, H},
	doi = {10.1016/j.chemphyslip.2023.105361},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {258},
	unique-id = {34633388},
	issn = {0009-3084},
	year = {2024},
	eissn = {1873-2941}
}

@article{MTMT:34616094,
	title = {The role of glucose and fructose on lipid droplet metabolism in human normal bronchial and cancer lung cells by Raman spectroscopy},
	url = {https://m2.mtmt.hu/api/publication/34616094},
	author = {Kopec, Monika and Beton-Mysur, Karolina},
	doi = {10.1016/j.chemphyslip.2023.105375},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {259},
	unique-id = {34616094},
	issn = {0009-3084},
	abstract = {Fructose is one of the most important monosaccharides in the human diet that the human body needs for proper metabolism. This paper presents an approach to study biochemical changes caused by sugars in human normal bronchial cells (BEpiC) and human cancer lung cells (A549) by Raman spectroscopy and Raman imaging. Results after supplementation of human bronchial and lung cells with fructose are also discussed and compared with results obtained for pure human bronchial and lung cells. Based on Raman techniques we have proved that peaks at 750 cm-1, 1126 cm-1, 1444 cm-1, 1584 cm-1 and 2845 cm- 1 can be treated as biomarkers to monitor fructose changes in cells. Results for fructose have been compared with results for glucose. Raman analysis of the bands at 750 cm-1, 1126 cm-1, 1584 cm-1 and 2845 cm- 1 for pure BEpiC and A549 cells and BEpiC and A549 after supplementation with fructose and glucose are higher after supplementation with fructose in comparison to glucose. The obtained results shed light on the uninvestigated influence of glucose and fructose on lipid droplet metabolism by Raman spectroscopy methods.},
	keywords = {Biomarkers; fructose; raman spectroscopy; lung cancer; Sugars; Raman imaging},
	year = {2024},
	eissn = {1873-2941}
}

@article{MTMT:34605086,
	title = {Structural changes in layers of lipid mixtures at low surface tensions},
	url = {https://m2.mtmt.hu/api/publication/34605086},
	author = {Bykov, A. G. and Panaeva, M. A. and Milyaeva, O. Y. and Michailov, A. V. and Rafikova, A. R. and Guzman, E. and Rubio, R. and Miller, R. and Noskov, B. A.},
	doi = {10.1016/j.chemphyslip.2023.105365},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {258},
	unique-id = {34605086},
	issn = {0009-3084},
	abstract = {Layers of pulmonary lipids on an aqueous substrate at non-equilibrium conditions can decrease the surface tension of water to quite low values. This is connected with different relaxation processes occurring at the interface and the associated changes in the surface layer structure. Results of measurements by the combination of methods like surface rheology, ellipsometry, Brewster angle microscopy, and IRRAS for spread layers of lipid mixtures open a possibility to specify the dynamics of structural changes at conditions close to the physiological state. At sufficiently low surface tension values (below 5 mN/m) significant changes in the ellipsometric signal were observed for pure DPPC layers, which can be related to a transition from 2D to 3D structures caused by the layer folding. The addition of other lipids can accelerate the relaxation processes connected with squeezing-out of molecules or multilayer stacks formation hampering thereby a decrease of surface tension down to low values corresponding to the folding of the monolayer.},
	keywords = {Ellipsometry; DPPC; Surface elasticity; pulmonary lipids; Monolayer collapse},
	year = {2024},
	eissn = {1873-2941}
}

@article{MTMT:34602701,
	title = {Interactions between macrophage membrane and lipid mediators during cardiovascular diseases with the implications of scavenger receptors},
	url = {https://m2.mtmt.hu/api/publication/34602701},
	author = {Ravi, Sangeetha and Martin, Livya Catherene and Krishnan, Mahalakshmi and Kumaresan, Manikandan and Manikandan, Beulaja and Ramar, Manikandan},
	doi = {10.1016/j.chemphyslip.2023.105362},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {258},
	unique-id = {34602701},
	issn = {0009-3084},
	abstract = {The onset and progression of cardiovascular diseases with the major underlying cause being atherosclerosis, occur during chronic inflammatory persistence in the vascular system, especially within the arterial wall. Such prolonged maladaptive inflammation is driven by macrophages and their key mediators are generally attributed to a disparity in lipid metabolism. Macrophages are the primary cells of innate immunity, endowed with expansive membrane domains involved in immune responses with their signalling systems. During atherosclerosis, the membrane domains and receptors control various active organisations of macrophages. Their scavenger/endocytic receptors regulate the trafficking of intracellular and extracellular cargo. Corresponding influence on lipid metabolism is mediated by their dynamic interaction with scavenger membrane receptors and their integrated mechanisms such as pinocytosis, phagocytosis, cholesterol export/import, etc. This interaction not only results in the functional differentiation of macrophages but also modifies their structural configurations. Here, we reviewed the association of macrophage membrane biomechanics and their scavenger receptor families with lipid metabolites during the event of atherogenesis. In addition, the membrane structure of macrophages and the signalling pathways involved in endocytosis integrated with lipid metabolism are detailed. This article establishes future insights into the scavenger receptors as potential targets for cardiovascular disease prevention and treatment.},
	keywords = {ATHEROSCLEROSIS; MACROPHAGES; MEMBRANE; lipid; Scavenger receptors},
	year = {2024},
	eissn = {1873-2941}
}

@article{MTMT:34584163,
	title = {The small-molecule kinase inhibitor ceritinib, unlike imatinib, causes a significant disturbance of lipid membrane integrity: A combined experimental and MD study},
	url = {https://m2.mtmt.hu/api/publication/34584163},
	author = {Fischer, Markus and Luck, Meike and Werle, Max and Vogel, Alexander and Bashawat, Mohammad and Ludwig, Kai and Scheidt, Holger A. and Mueller, Peter},
	doi = {10.1016/j.chemphyslip.2023.105351},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {257},
	unique-id = {34584163},
	issn = {0009-3084},
	abstract = {Ceritinib and imatinib are small-molecule protein kinase inhibitors which are applied as therapeutic agents against various diseases. The fundamentals of their clinical use, i.e. their pharmacokinetics as well as the mechanisms of the inhibition of the respective kinases, are relatively well studied. However, the interaction of the drugs with membranes, which can be a possible cause of side effects, has hardly been investigated so far. Therefore, we have characterized the interaction of both drugs with lipid membranes consisting of 1-palmitoyl-2oleoyl-sn-glycero-3-phosphocholine (POPC) in the absence and in the presence of cholesterol. For determining the membrane impact of both drugs on a molecular level, different experimental (NMR, ESR, fluorescence) and theoretical (MD simulations) approaches were applied. The data show that ceritinib, in contrast to imatinib, interacts more effectively with membranes significantly affecting various physico-chemical membrane parameters like membrane order and transmembrane permeation of polar solutes. The pronounced membrane impact of ceritinib can be explained by a strong affinity of the drug towards POPC which competes with the POPCcholesterol interaction by that attenuating the ordering effect of cholesterol. The data are relevant for understanding putative toxic and cytotoxic side effects of these drugs such as the triggering of cell lysis or apoptosis.},
	keywords = {molecular dynamics; imatinib; membrane structure; Lipid membranes; ceritinib; Small-molecule kinase inhibitors},
	year = {2023},
	eissn = {1873-2941},
	orcid-numbers = {Ludwig, Kai/0000-0001-6808-8107}
}

@article{MTMT:34337434,
	title = {Effect of cholesterol on the ion-membrane interaction: Zeta potential and dynamic light scattering study},
	url = {https://m2.mtmt.hu/api/publication/34337434},
	author = {Banerjee, Kalyan Kumar and Maity, Pabitra and Das, Surajit and Karmakar, Sanat},
	doi = {10.1016/j.chemphyslip.2023.105307},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {254},
	unique-id = {34337434},
	issn = {0009-3084},
	abstract = {Cholesterol in a bio-membrane plays a significant role in many cellular event and is known to regulate the functional activity of protein and ion channel. In this study we report a significant effect of cholesterol on the ionmembrane interaction. We prepare large unilamellar vesicles, composed of zwitterionic lipid DOPC and anionic lipid DOPG with different cholesterol concentration. Electrostatics of anionic membranes containing cholesterol in the presence of NaCl has systematically been explored using dynamic light scattering and zeta potential. Negative zeta potential of the membrane decreases its negative value with increasing ion concentration for all cholesterol concentrations. However, zeta potential itself decreases with increasing cholesterol content even in the absence of monovalent ions. Electrostatic behaviour of the membrane is determined from well-known Gouy Chapmann model. Negative surface charge density of the membrane decreases with increasing cholesterol content. Binding constant, estimated from the electrostatic double layer theory, is found to increase significantly in the presence of cholesterol. Comparison of electrostatic parameters of the membrane in the presence and absence of cholesterol suggests that cholesterol significantly alter the electrostatic behaviour of the membrane.},
	keywords = {phospholipids; cholesterol; DLS; alkali metal ions; zeta potential; bio-membrane},
	year = {2023},
	eissn = {1873-2941}
}

@article{MTMT:34082735,
	title = {Recent advances in regulating lipid metabolism to prevent coronary heart disease},
	url = {https://m2.mtmt.hu/api/publication/34082735},
	author = {Du, J. and Wu, W. and Zhu, B. and Tao, W. and Liu, L. and Cheng, X. and Zhao, M. and Wu, J. and Li, Y. and Pei, K.},
	doi = {10.1016/j.chemphyslip.2023.105325},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {255},
	unique-id = {34082735},
	issn = {0009-3084},
	abstract = {The pathogenesis of coronary heart disease is a highly complex process, with lipid metabolism disorders being closely linked to its development. Therefore, this paper analyzes the various factors that influence lipid metabolism, including obesity, genes, intestinal microflora, and ferroptosis, through a comprehensive review of basic and clinical studies. Additionally, this paper delves deeply into the pathways and patterns of coronary heart disease. Based on these findings, it proposes various intervention pathways and therapeutic methods, such as the regulation of lipoprotein enzymes, lipid metabolites, and lipoprotein regulatory factors, as well as the modulation of intestinal microflora and the inhibition of ferroptosis. Ultimately, this paper aims to offer new ideas for the prevention and treatment of coronary heart disease. © 2023 Elsevier B.V.},
	keywords = {ATHEROSCLEROSIS; lipid metabolism; Coronary heart disease; PREVENTIVE TREATMENT; influencing factors},
	year = {2023},
	eissn = {1873-2941}
}

@article{MTMT:33967892,
	title = {Ionizable lipids penetrate phospholipid bilayers with high phase transition temperatures: perspectives from free energy calculations},
	url = {https://m2.mtmt.hu/api/publication/33967892},
	author = {Ermilova, Inna and Swenson, Jan},
	doi = {10.1016/j.chemphyslip.2023.105294},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {253},
	unique-id = {33967892},
	issn = {0009-3084},
	abstract = {The efficacies of modern gene-therapies strongly depend on their contents. At the same time the most potent formulations might not contain the best compounds. In this work we investigated the effect of phospholipids and their saturation on the binding ability of (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethyla-mino) butanoate (DLin-MC3-DMA) to model membranes at the neutral pH. We discovered that DLin-MC3-DMA has affinity to the most saturated monocomponent lipid bilayer 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and an aversion to the unsaturated one 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC). The prefer-ence to a certain membrane was also well-correlated to the phase transition temperatures of phospholipid bi-layers, and to their structural and dynamical properties. Additionally, in the case of the presence of DLin-MC3-DMA in the membrane with DOPC the ionizable lipid penetrated it, which indicates possible synergistic effects. Comparisons with other ionizable lipids were performed using a model lipid bilayer of 1-palmitoyl-2-oleoyl-glyc-ero-3-phosphocholine (POPC). Particularly, the lipids heptadecan-9-yl 8-[2-hydroxyethyl-(6-oxo-6-undecoxy-hexyl)amino]octanoate (SM-102) and [(4-hydroxybutyl) azanediyl] di(hexane-6,1-diyl) bis(2-hexyldecanoate) (ALC-0315) from modern mRNA-vaccines against COVID-19 were investigated and force fields parameters were derived for those new lipids. It was discovered that ALC-0315 binds strongest to the membrane, while DLin-MC3-DMA is not able to reside in the bilayer center. The ability to penetrate the membrane POPC by SM-102 and ALC-0315 can be related to their saturation, comparing to DLin-MC3-DMA.},
	keywords = {lipid bilayer; phase transition; ionizable lipids; SM-102; ALC-0315; DLin-MC3-DMA},
	year = {2023},
	eissn = {1873-2941},
	orcid-numbers = {Ermilova, Inna/0000-0001-7371-8644}
}

@article{MTMT:33626231,
	title = {Challenges and emerging strategies for next generation liposomal based drug delivery: An account of the breast cancer conundrum},
	url = {https://m2.mtmt.hu/api/publication/33626231},
	author = {Moudgil, A. and Salve, R. and Gajbhiye, V. and Chaudhari, B.P.},
	doi = {10.1016/j.chemphyslip.2022.105258},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {250},
	unique-id = {33626231},
	issn = {0009-3084},
	abstract = {The global cancer burden is witnessing an upsurge with breast cancer surpassing other cancers worldwide. Furthermore, an escalation in the breast cancer caseload is also expected in the coming years. The conventional therapeutic regimens practiced routinely are associated with many drawbacks to which nanotechnological interventions offer a great advantage. But how eminent could liposomes and their advantages be in superseding these existing therapeutic modalities? A solution is reflected in this review that draws attention to a decade-long journey embarked upon by researchers in this wake. This text is a comprehensive discussion of liposomes, the front runners of the drug delivery systems, and their active and passive targeting approaches for breast cancer management. Active targeting has been studied over the decade by many receptors overexpressed on the breast cancer cells and passive targeting with many drug combinations. The results converge on the fact that the actively targeted formulations exhibit a superior efficacy over their non-targeted counterparts and the all liposomal formulations are efficacious over the free drugs. This undoubtedly underlines the dominion of liposomal formulations over conventional chemotherapy. These investigations have led to the development of different liposomal formulations with active and passive targeting capacities that could be explored in depth. Acknowledging and getting a deeper insight into the liposomal evolution through time also unveiled many imperfections and unchartered territories that can be explored to deliver dexterous liposomal formulations against breast cancer and more in the clinical trial pipeline. © 2022 Elsevier B.V.},
	keywords = {Female; Female; Humans; human; Breast Neoplasms; drug delivery system; Drug Delivery Systems; Liposomes; Liposome; breast tumor; breast cancer; Nanotechnology; Nanotechnology; Targeted drug delivery; Liposomal metamorphosis; Receptor-ligand dynamics},
	year = {2023},
	eissn = {1873-2941}
}

@article{MTMT:33623389,
	title = {Interaction of psychedelic tryptamine derivatives with a lipid bilayer},
	url = {https://m2.mtmt.hu/api/publication/33623389},
	author = {Zohairi, F. and Khandelia, H. and Hakami, Zanjani A.A.},
	doi = {10.1016/j.chemphyslip.2023.105279},
	journal-iso = {CHEM PHYS LIPIDS},
	journal = {CHEMISTRY AND PHYSICS OF LIPIDS},
	volume = {251},
	unique-id = {33623389},
	issn = {0009-3084},
	abstract = {Naturally occurring psychedelics have been used for a long time as remedies or in religious ceremonies and recreational activities. Recent studies have proven the therapeutic potential of some psychedelic compounds to safely treat a wide range of diseases such as anxiety, depression, migraine, and addiction. It is hypothesized that psychedelic compounds like tryptamines can exert their effects by two possible mechanisms: binding to the transmembrane serotonin receptor and/or modifying the properties of the neuronal membrane that can alter the conformational equilibrium and desensitize receptors. The impact of three different tryptamine class compounds with a tertiary amine (dimethyltryptamine, bufotenine, and 5-MeO-DMT) in both neutral and charged forms on a model bilayer lipid membrane are studied using all-atom MD simulations. All compounds partition into the bilayer, and change membrane properties, but to different extents. We determine the tendency of compounds to partition into the membrane by free energy calculations. Neutral tryptamines partition into the bilayer almost completely. Dimethyltryptamine and 5-MeO-DMT cross the membrane spontaneously during the simulation time, but bufotenine does not, although it has the maximum effect on the structural properties of the membrane. However, protonated compounds partition partially into the bilayer and cannot pass through the middle of the membrane during the simulation time. In this way, subtle alteration of chemical structure can play a significant role in the improvement or deterioration of partitioning of these compounds into the bilayer and their passage across the membrane. © 2023 The Authors},
	keywords = {SEROTONIN; tryptamine; DMT; molecular dynamics (MD) simulations; 5-MeO-DMT; psilocin; Bufotenine; Lipid-compound interactions; Psychedelic compounds},
	year = {2023},
	eissn = {1873-2941}
}