TY - JOUR AU - Wang, S. AU - Ma, S. AU - Li, H. AU - Dao, M. AU - Li, X. AU - Karniadakis, G.E. TI - Two-component macrophage model for active phagocytosis with pseudopod formation JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J PY - 2024 SN - 0006-3495 DO - 10.1016/j.bpj.2024.03.026 UR - https://m2.mtmt.hu/api/publication/34813233 ID - 34813233 N1 - Department of Engineering Mechanics and Center for X-Mechanics, Zhejiang University, Zhejiang, Hangzhou, China School of Chemical, Materials and Biomedical Engineering, University of Georgia, Georgia, Athens, Georgia Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States Division of Applied Mathematics, Brown University, Providence, Rhode Island, United States Cited By :1 Export Date: 23 April 2024 CODEN: BIOJA Correspondence Address: Li, X.; Department of Engineering Mechanics and Center for X-Mechanics, Zhejiang, China; email: xuejin_li@zju.edu.cn AB - Macrophage phagocytosis is critical for the immune response, homeostasis regulation, and tissue repair. This intricate process involves complex changes in cell morphology, cytoskeletal reorganization, and various receptor-ligand interactions controlled by mechanical constraints. However, there is a lack of comprehensive theoretical and computational models that investigate the mechanical process of phagocytosis in the context of cytoskeletal rearrangement. To address this issue, we propose a novel coarse-grained mesoscopic model that integrates a fluid-like cell membrane and a cytoskeletal network to study the dynamic phagocytosis process. The growth of actin filaments results in the formation of long and thin pseudopods, and the initial cytoskeleton can be disassembled upon target entry and reconstructed after phagocytosis. Through dynamic changes in the cytoskeleton, our macrophage model achieves active phagocytosis by forming a phagocytic cup utilizing pseudopods in two distinct ways. We have developed a new algorithm for modifying membrane area to prevent membrane rupture and ensure sufficient surface area during phagocytosis. In addition, the bending modulus, shear stiffness, and cortical tension of the macrophage model are investigated through computation of the axial force for the tubular structure and micropipette aspiration. With this model, we simulate active phagocytosis at the cytoskeletal level and investigate the mechanical process during the dynamic interplay between macrophage and target particles. © 2024 Biophysical Society LA - English DB - MTMT ER - TY - JOUR AU - Satalkar, V. AU - Degaga, G.D. AU - Li, W. AU - Pang, Y.T. AU - McShan, A.C. AU - Gumbart, J.C. AU - Mitchell, J.C. AU - Torres, M.P. TI - Generative β-hairpin design using a residue-based physicochemical property landscape JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J PY - 2024 SN - 0006-3495 DO - 10.1016/j.bpj.2024.01.029 UR - https://m2.mtmt.hu/api/publication/34740708 ID - 34740708 N1 - School of Biological Sciences, Georgia Institute of Technology, Georgia, Atlanta, Georgia Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States School of Physics, Georgia Institute of Technology, Georgia, Atlanta, Georgia School of Chemistry and Biochemistry, Georgia Institute of Technology, Georgia, Atlanta, Georgia Export Date: 14 March 2024 CODEN: BIOJA Correspondence Address: Mitchell, J.C.; Biosciences Division, United States; email: mitchelljc@ornl.gov Correspondence Address: Torres, M.P.; School of Biological Sciences, Georgia, Georgia; email: mtorres35@gatech.edu LA - English DB - MTMT ER - TY - JOUR AU - Bannish, Brittany E. AU - Paynter, Bradley AU - Risman, Rebecca AU - Shroff, Mitali AU - Tutwiler, Valerie TI - The effect of plasmin-mediated degradation on fibrinolysis and tissue plasminogen activator diffusion JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J VL - 123 PY - 2024 SN - 0006-3495 DO - 10.1016/j.bpj.2024.02.002 UR - https://m2.mtmt.hu/api/publication/34608490 ID - 34608490 LA - English DB - MTMT ER - TY - JOUR AU - Weakly, H.M.J. AU - Keller, S.L. TI - Coupling liquid phases in 3D condensates and 2D membranes: Successes, challenges, and tools JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J VL - in press PY - 2024 SP - in press SN - 0006-3495 DO - 10.1016/j.bpj.2023.12.023 UR - https://m2.mtmt.hu/api/publication/34567316 ID - 34567316 LA - English DB - MTMT ER - TY - JOUR AU - Uppal, G. AU - Vural, D.C. TI - On the possibility of engineering social evolution in microfluidic environments JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J VL - 123 PY - 2024 IS - 3 SP - 407 EP - 419 PG - 13 SN - 0006-3495 DO - 10.1016/j.bpj.2024.01.007 UR - https://m2.mtmt.hu/api/publication/34716387 ID - 34716387 LA - English DB - MTMT ER - TY - JOUR AU - Pálinkás, János AU - Harami, Gábor AU - Kovács, Zoltán AU - Jezsó, Bálint AU - Tárnok, Krisztián AU - Harami-Papp, Hajnalka AU - Hegedüs, József AU - Mahmudova, Lamiya AU - Házy, Eszter AU - Ecsédi, Péter AU - Kucsma, Nóra AU - Tóth, Szilárd AU - Szakács, Gergely AU - Kovács, Mihály TI - Redox-dependent phase separation and cytoplasmic granulation by human single-stranded DNA binding protein 1 (HSSB1) point to new mechanisms of cellular stress response JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J VL - 123 PY - 2024 IS - 3 SP - 41a SN - 0006-3495 DO - 10.1016/j.bpj.2023.11.329 UR - https://m2.mtmt.hu/api/publication/34685876 ID - 34685876 LA - English DB - MTMT ER - TY - JOUR AU - Ecsédi, Péter AU - Pálinkás, János AU - Kovács, Zoltán AU - Harami, Gábor AU - Juhasz, Tunde AU - Jezsó, Bálint AU - Erfalvy, David AU - Mahmudova, Lamiya AU - Házy, Eszter AU - Beke-Somfai, Tamas AU - Kovács, Mihály TI - Functional contribution of condensate formation by single-stranded DNA binding protein (SSB) to bacterial genome maintenance JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J VL - 123 PY - 2024 IS - 3 SP - 79a EP - 80a SN - 0006-3495 DO - 10.1016/j.bpj.2023.11.547 UR - https://m2.mtmt.hu/api/publication/34685848 ID - 34685848 LA - English DB - MTMT ER - TY - JOUR AU - Keshavanarayana, P. AU - Spill, F. TI - A mechanical modeling framework to study endothelial permeability JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J VL - 123 PY - 2024 IS - 3 SP - 334 EP - 348 PG - 15 SN - 0006-3495 DO - 10.1016/j.bpj.2023.12.026 UR - https://m2.mtmt.hu/api/publication/34685723 ID - 34685723 N1 - Export Date: 26 February 2024 CODEN: BIOJA Correspondence Address: Keshavanarayana, P.; School of Mathematics, United Kingdom; email: p.keshavanarayana@bham.ac.uk Correspondence Address: Spill, F.; School of Mathematics, United Kingdom; email: f.spill@bham.ac.uk LA - English DB - MTMT ER - TY - JOUR AU - Brown, W.H. AU - Potoyan, D.A. TI - Phase separation of multicomponent peptide mixtures into dehydrated clusters with hydrophilic cores JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J VL - 123 PY - 2024 IS - 3 SP - 349 EP - 360 PG - 12 SN - 0006-3495 DO - 10.1016/j.bpj.2023.12.027 UR - https://m2.mtmt.hu/api/publication/34657764 ID - 34657764 N1 - Export Date: 21 February 2024 CODEN: BIOJA Correspondence Address: Potoyan, D.A.; Department of Chemistry, United States; email: potoyan@iastate.edu LA - English DB - MTMT ER - TY - JOUR AU - Banerjee, Puja AU - Qu, Kun AU - Briggs, John A.G. AU - Voth, Gregory A. TI - Molecular dynamics simulations of HIV-1 matrix-membrane interactions at different stages of viral maturation JF - BIOPHYSICAL JOURNAL J2 - BIOPHYS J VL - 123 PY - 2024 IS - 3 SP - 389 EP - 406 PG - 18 SN - 0006-3495 DO - 10.1016/j.bpj.2024.01.006 UR - https://m2.mtmt.hu/api/publication/34645981 ID - 34645981 N1 - Department of Chemistry, Chicago Center for Theoretical Chemistry, Institute for Biophysical Dynamics, and James Franck Institute, The University of Chicago, Chicago, Illinois, United States Infectious Diseases Translational Research Programme, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Department of Cell and Virus Structure, Max Planck Institute of Biochemistry, Planegg, Germany Cited By :1 Export Date: 24 April 2024 CODEN: BIOJA Correspondence Address: Voth, G.A.; Department of Chemistry, United States; email: gavoth@uchicago.edu LA - English DB - MTMT ER -