@article{MTMT:34743928,
	title = {Crocetin protects mouse brain from apoptosis in traumatic brain injury model through activation of autophagy},
	url = {https://m2.mtmt.hu/api/publication/34743928},
	author = {Chen, S. and Luo, X. and Yang, L. and Luo, L. and Hu, Z. and Wang, J.},
	doi = {10.1080/02699052.2024.2324022},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {34743928},
	issn = {0269-9052},
	year = {2024},
	eissn = {1362-301X}
}

@article{MTMT:34674832,
	title = {The epidemiological characteristics of pediatric head injury in Hangzhou, China: a retrospective study based on cranial CT examinations},
	url = {https://m2.mtmt.hu/api/publication/34674832},
	author = {Li, Haomin and Ding, Yushuang and Zhou, Haichun and Hu, Lei and Feng, Yuqing and Shen, Zhipeng and Zhang, Hongxi and Shu, Liqi and Tan, Linhua},
	doi = {10.1080/02699052.2024.2309545},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {34674832},
	issn = {0269-9052},
	keywords = {CHINA; EPIDEMIOLOGY; traumatic brain injury; CT scan; Pediatric head injury},
	year = {2024},
	eissn = {1362-301X},
	orcid-numbers = {Li, Haomin/0000-0002-6420-7719}
}

@article{MTMT:34660957,
	title = {The Participation Assessment with Recombined Tools-Objective (PART-O): measurement properties of the Norwegian version after traumatic brain injury},
	url = {https://m2.mtmt.hu/api/publication/34660957},
	author = {Roe, Cecilie and Borgen, Ida M. H. and Fure, Silje C. R. and Forslund, Marit V. and Kleffelgard, Ingerid and Andelic, Nada and Lovstad, Marianne and Hauger, Solveig L.},
	doi = {10.1080/02699052.2024.2304855},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {34660957},
	issn = {0269-9052},
	keywords = {PARTICIPATION; disability; brain injury; RASCH ANALYSIS; traumatic},
	year = {2024},
	eissn = {1362-301X}
}

@article{MTMT:34660249,
	title = {Timing of withdrawal of life-sustaining therapy in traumatic brain injury: exploring indicators of poor prognosis in adult and geriatric populations},
	url = {https://m2.mtmt.hu/api/publication/34660249},
	author = {Bath, Jennifer and Barylak, Martin and Kedda, Edward and Harvey, Ellen and Locklear, Tonja and Martinez, Melissa and Collier, Bryan and Weppner, Justin},
	doi = {10.1080/02699052.2024.2309656},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {34660249},
	issn = {0269-9052},
	keywords = {MORTALITY; Prognosis; Risk Factors; traumatic brain injury; prognostic indicators},
	year = {2024},
	eissn = {1362-301X}
}

@article{MTMT:34640757,
	title = {Sodium aescinate ameliorates chronic neuropathic pain in male mice via suppressing JNK/p38-mediated microglia activation},
	url = {https://m2.mtmt.hu/api/publication/34640757},
	author = {Xie, Wenqiang and Hou, Jie and Li, Changke and Zhang, Qiang},
	doi = {10.1080/02699052.2024.2307966},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {34640757},
	issn = {0269-9052},
	keywords = {Neuropathic pain; microglia; sodium aescinate; the JNK/p38 signaling pathway; chronic contraction injury},
	year = {2024},
	eissn = {1362-301X}
}

@article{MTMT:34619793,
	title = {MiR-221-5p regulates blood-brain barrier dysfunction through the angiopoietin-1/-2/Tie-2 signaling axis after subarachnoid hemorrhage},
	url = {https://m2.mtmt.hu/api/publication/34619793},
	author = {Gu, Hua and Zhong, Xing-Ming and Cai, Yong and Dong, Zhao-Hui},
	doi = {10.1080/02699052.2024.2309263},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {34619793},
	issn = {0269-9052},
	abstract = {AimTo explore the potential role of microRNA miR-221-5p on the angiopoietin-1 (Ang-1)/Ang-2/Tie-2 signaling axis after subarachnoid hemorrhage (SAH) in a rat model.MethodsAspects of the rat's behavior were measured using the Kaoutzanis scoring system to test neurological responses. This included feeding behavior, body contraction, motor, and eye-opening responses. Brain sections were studied using transmission electron microscopy and Evans blue extravasation. Levels of Ang-1, Ang-2, and Tie-2 were determined by Western blot, while miR-221-5p was quantified using stem-loop real-time quantitative PCR (RT-qPCR).ResultsThe SAH group responded worse to the neurological response test than the sham-operated group. The intercellular space was widened in the SAH group, but not in the sham-operated group. Evans blue dye leaked significantly more into brain tissue cells of the SAH group. Stem-loop qRT-PCR showed elevated miR-221-5p levels. Additionally, Ang-1 and Tie-2 were reduced but Ang-2 expression was increased after SAH. This led to a significant reduction of the Ang-1/Ang-2 ratio in the brain tissue, which was associated with the destruction of the blood-brain barrier.ConclusionThe data indicate that miR-221-5p might regulate blood-brain barrier dysfunction through the Ang-1/Ang-2/Tie-2 signaling axis, suggesting that it should be further investigated as a potential novel biomarker.},
	keywords = {SUBARACHNOID HEMORRHAGE; Tie-2; blood-brain barrier dysfunction; Ang-2; miR-221-5p; Ang-1},
	year = {2024},
	eissn = {1362-301X}
}

@article{MTMT:34356349,
	title = {Olfactory training effects in children after mild traumatic brain injury},
	url = {https://m2.mtmt.hu/api/publication/34356349},
	author = {Pieniak, Michal and Seidel, Katharina and Oleszkiewicz, Anna and Gellrich, Janine and Karpinski, Christian and Fitze, Guido and Schriever, Valentin A.},
	doi = {10.1080/02699052.2023.2237889},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {34356349},
	issn = {0269-9052},
	abstract = {ObjectiveMild traumatic brain injury (mTBI) might impair the sense of smell and cognitive functioning. Repeated, systematic exposure to odors, i.e., olfactory training (OT) has been proposed for treatment of olfactory dysfunctions, including post-traumatic smell loss. Additionally, OT has been shown to mitigate cognitive deterioration in older population and enhance selected cognitive functions in adults. We aimed to investigate olfactory and cognitive effects of OT in the pediatric population after mTBI, likely to exhibit cognitive and olfactory deficits.MethodsOur study comprised 159 children after mTBI and healthy controls aged 6-16 years (M = 9.68 & PLUSMN; 2.78 years, 107 males), who performed 6-months-long OT with a set of 4 either high- or low-concentrated odors. Before and after OT we assessed olfactory functions, fluid intelligence, and executive functions.ResultsOT with low-concentrated odors increased olfactory sensitivity in children after mTBI. Regardless of health status, children who underwent OT with low-concentrated odors had higher fluid intelligence scores at post-training measurement, whereas scores of children performing OT with high-concentrated odors did not change.ConclusionOur study suggests that OT with low-concentrated odors might accelerate rehabilitation of olfactory sensitivity in children after mTBI and support cognitive functions in the area of fluid intelligence regardless of head trauma.},
	keywords = {cognition; head injury; executive functions; olfaction; fluid intelligence},
	year = {2023},
	eissn = {1362-301X},
	orcid-numbers = {Pieniak, Michal/0000-0002-2991-7109; Gellrich, Janine/0000-0002-7336-5815}
}

@article{MTMT:34036238,
	title = {The relationship between cognitive reserve and outcome after controlling for psychological status and sex following mild traumatic brain injury},
	url = {https://m2.mtmt.hu/api/publication/34036238},
	author = {Anderson, Jacqueline F. I. and Martin, Laura},
	doi = {10.1080/02699052.2023.2222642},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {34036238},
	issn = {0269-9052},
	abstract = {ObjectiveCognitive reserve is the brain's ability to optimize performance by differentially recruiting brain networks. It is easily measured and is reportedly associated with post-concussion symptom (PCS) reporting in the post-acute period after mild traumatic brain injury (mTBI). Past studies have not examined whether this relationship exists when the influence of psychological status is removed, despite this factor being strongly associated with symptom reporting. This study investigated whether cognitive reserve predicts PCS reporting or cognitive complaint in the post-acute period after mTBI, independently from psychological status and sex.MethodNinety-four pre-morbidly healthy adults were assessed on three measures of cognitive reserve, as well as measures of post-concussion symptoms, cognitive complaint, and psychological status.ResultsBivariate analyses revealed significant relationships between measures of cognitive reserve and both PCS reporting (p < 0.01) and cognitive complaint (<.05). After removing the influence of psychological distress and sex, however, no measure of cognitive reserve significantly predicted any type of symptom reporting.ConclusionThese findings indicate that cognitive reserve does not independently predict symptom reporting 9 weeks after mTBI, and clinicians should not incorporate this factor into their decision-making regarding likelihood of ongoing symptom reporting and the consequent need for intervention in the post-acute period after mTBI.},
	keywords = {RECOVERY; Health; symptomatology; Mild traumatic brain injury; QUALITY-OF-LIFE; COMPLAINTS; Neurosciences; post-concussion symptoms; post-concussion symptoms; Cognitive Reserve; Cognitive symptoms},
	year = {2023},
	eissn = {1362-301X},
	orcid-numbers = {Anderson, Jacqueline F. I./0000-0003-4996-8189; Martin, Laura/0000-0001-6679-7700}
}

@article{MTMT:33950838,
	title = {Effectiveness of exercise in improving quality of life in patients with traumatic brain injury: A systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/33950838},
	author = {Chang, Chia-Wen and Tzeng, Hsin-Ya and Ma, Ching-Yuan and Li, Shih-Ting and Chen, Kuan-Jung and Chiang, Hui-Hsun},
	doi = {10.1080/02699052.2023.2165155},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {33950838},
	issn = {0269-9052},
	abstract = {BackgroundTraumatic brain injury (TBI) is a major cause of disability and mortality worldwide. People with TBI exhibit poor quality of life (QOL). Exercise is considered a possible intervention for improving cognitive function and mood, helping improve QOL in patients with TBI. According to our review of the relevant literature, meta-analyses have yet to explore the effect of exercise on QOL in patients with TBI.ObjectivesTo determine by meta-analysis of relevant studies whether physical exercise could promote QOL in patients with TBI.MethodsA systematic review and meta-analysis of intervention studies involving physical exercise for improving QOL outcomes in TBI populations were conducted according to the PRISMA guideline. Our inclusion criteria were as follows: being randomized or nonrandomized controlled trials with quantitative designs that included patients diagnosed with TBI.ResultsThus, six studies met the inclusion criteria. The interventions in four of the six studies had statistically significant effects on QOL improvement. Our meta-analysis revealed a moderate effect size of physical exercise on QOL promotion in patients with TBI.ConclusionFor TBI, exercise seems to improve QOL. More research with long-term follow-up should be conducted to assess the effect of exercise on patients with TBI.},
	keywords = {Quality of Life; physical activity; Exercise; traumatic brain injury; Aerobic training},
	year = {2023},
	eissn = {1362-301X},
	orcid-numbers = {Chiang, Hui-Hsun/0000-0001-7193-5653}
}

@article{MTMT:33941500,
	title = {Hyperosmolar therapies for neurological deterioration in mild and moderate traumatic brain injury: A scoping review},
	url = {https://m2.mtmt.hu/api/publication/33941500},
	author = {Marchesini, Nicolo and Londono, Laura Lucia Fernandez and Boaro, Alessandro and Kuhn, Isla and Griswold, Dylan and Sala, Francesco and Rubiano, Andres M.},
	doi = {10.1080/02699052.2023.2191010},
	journal-iso = {BRAIN INJURY},
	journal = {BRAIN INJURY},
	unique-id = {33941500},
	issn = {0269-9052},
	abstract = {ObjectiveTo explore the available evidence on hyperosmolar therapies(HT) in mild and moderate traumatic brain injury(TBI) and to evaluate the effects on outcomes.A scoping review was conducted according to the Joanna Briggs Institute methodology. Inclusion criteria: (a)randomized controlled trials(RCTs), prospective and retrospective cohort studies and case-control studies; (b)all-ages mild and moderate TBIs; (c)HT administration; (d)functional outcomes recorded; (e)comparator group.ResultsFrom 4424 records, only 3 respected the inclusion criteria. In a retrospective cohort study of adult moderate TBIs, the Glasgow Coma Scale(GCS) remained the same at 48 hours in those treated with hypertonic saline(HTS) while it worsened in the non-treated. A trend toward increased pulmonary infections and length of stay was found. In an RCT of adult severe and moderate TBIs, moderate TBIs treated with HTS showed a trend toward better secondary outcomes than standard care alone, with similar odds of adverse effects. An RCT enrolling children with mild TBI found a significant improvement in concussive pain immediately after HTS administration and after 2-3 days. No adverse events occurred.ConclusionsA gap in the literature about HTs' role in mild and moderate TBI was found. Some benefits may exist with limited side effects and further studies are desirable.},
	keywords = {Brain Injuries; outcome; TBI; Neurotrauma; hyperosmolar},
	year = {2023},
	eissn = {1362-301X},
	orcid-numbers = {Griswold, Dylan/0000-0003-0291-8360}
}