TY  - JOUR
AU  - Junttola, Ulla
AU  - Liisanantti, Janne
AU  - Isokangas, Juha-Matti
AU  - Kaakinen, Timo
AU  - Vakkala, Merja
AU  - Lahtinen, Sanna
TI  - Quality of Life After Endovascular Thrombectomy for Acute Ischemic Stroke in Northern Finland
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2024
PY  - 2024
PG  - 9
SN  - 0001-6314
DO  - 10.1155/2024/6684746
UR  - https://m2.mtmt.hu/api/publication/35270686
ID  - 35270686
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sempik, Izabela
AU  - Dziadkowiak, Edyta
AU  - Wieczorek, Malgorzata
AU  - Pokryszko-Dragan, Anna
TI  - Sleep Disturbance and Related Factors in the Patients with Relapsing-Remitting Multiple Sclerosis
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2024
PY  - 2024
PG  - 9
SN  - 0001-6314
DO  - 10.1155/2024/6656571
UR  - https://m2.mtmt.hu/api/publication/34977257
ID  - 34977257
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Takahashi, Kensuke
AU  - Kurihara, Masanori
AU  - Ishibashi, Kenji
AU  - Komori, Yuta
AU  - Goto, Ryoji
AU  - Higashihara, Mana
AU  - Kameyama, Masashi
AU  - Hirano, Hirohiko
AU  - Maeda, Meiko Hashimoto
AU  - Watanabe, Rie
AU  - Ishii, Kenji
AU  - Iwata, Atsushi
TI  - Increased <SUP>18</SUP>F-THK5351 Uptake at Bilateral Primary Motor Cortex in Patients with Progressive Pseudobulbar Palsy
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2024
PY  - 2024
PG  - 6
SN  - 0001-6314
DO  - 10.1155/2024/4310875
UR  - https://m2.mtmt.hu/api/publication/34965495
ID  - 34965495
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Feng, Zijuan
AU  - Chen, Ting
AU  - Liu, Peng
AU  - Zhang, Ziyi
AU  - Wang, Zhetao
AU  - Wang, Yanan
AU  - Song, Quhong
AU  - Ye, Chen
AU  - Liu, Ming
AU  - Zhang, Shuting
TI  - Joint Association of Low Nadir Serum Sodium and Potassium with Worse Outcomes after Ischemic Stroke
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2024
PY  - 2024
PG  - 8
SN  - 0001-6314
DO  - 10.1155/2024/5541608
UR  - https://m2.mtmt.hu/api/publication/34926784
ID  - 34926784
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Thapa, S.
AU  - Shah, S.
AU  - Bhattarai, A.
AU  - Yadav, R.
AU  - Yu, F.
AU  - Chand, S.
AU  - Li, J.
TI  - The Role of Biomarkers Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Vasoactive Intestinal Peptide (VIP) in Chronic and Episodic Migraines: A Meta-Analysis
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2024
PY  - 2024
SN  - 0001-6314
DO  - 10.1155/2024/2954374
UR  - https://m2.mtmt.hu/api/publication/34566742
ID  - 34566742
N1  - Department of Neurology, Westchester Medical Center, New York Medical CollegeNY, United States            
            Institute of Medicine, Tribhuvan University, Maharajgunj, 44600, Nepal            
            Department of Cardiology Westchester Medical Center, New York Medical CollegeNY, United States            
            Export Date: 8 February 2024            
            CODEN: ANRSA            
            Correspondence Address: Shah, S.; Institute of Medicine, Nepal; email: sangam.shah.1997@gmail.com            
            Chemicals/CAS: hypophysis adenylate cyclase activating polypeptide, 137061-48-4; vasoactive intestinal polypeptide, 37221-79-7
AB  - Background. Migraine is a neurological disorder that results in disability accumulation, and there are no blood-based markers for indicating migraine susceptibility. Here, we aimed to evaluate the possible biomarker role of neuropeptides, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating polypeptide (PACAP) in chronic (CM) and episodic migraine (EM). Method. PubMed, medRxiv, and Google Scholar databases were searched up to the 7th of September 2022 using the search syntax to define all relevant articles addressing the plasma and serum levels of VIP and PACAP in migraineurs and controls. Concerning bias assessment, the risk of bias in nonrandomized studies-I (ROBINS-I) was assessed. Also, the standardized mean difference (SMD) was measured with a random effects model. Results. Five case-control studies with 503 migraine cases were included. CM patients had elevated VIP levels compared to controls (SMD=0.44, 95% CI 0.25-0.62, p<0.00001). In contrast, PACAP levels were lower in EM patients (SMD=-0.30, 95% CI -0.48 to -0.11, p=0.002). Overall, migraine cases had higher VIP levels (SMD=0.25, 95% CI 0.11-0.39, p=0.0006) but lower PACAP levels (SMD=-0.16, 95% CI -0.30 to -0.03, p=0.020) than controls. Conclusion. The results support the role of VIP and PACAP neuropeptides in migraine pathophysiology. CM patients have significantly higher serum VIP levels, while EM patients have lower serum PACAP levels compared to controls. Further studies should confirm these findings. © 2024 Sangharsha Thapa et al.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tufvesson, Hanna
AU  - Hamrefors, Viktor
AU  - Roth, Bodil
AU  - Fedorowski, Artur
AU  - Ohlsson, Bodil
TI  - Sociodemographic Factors, Nutritional Status, and Inflammatory Markers in Patients with Postural Orthostatic Tachycardia Syndrome
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2023
PY  - 2023
PG  - 9
SN  - 0001-6314
DO  - 10.1155/2023/3992718
UR  - https://m2.mtmt.hu/api/publication/34877687
ID  - 34877687
N1  - Funding Agency and Grant Number: Development Foundation of Region Skane
            Funding text: The study is funded by grants from the Development Foundation of Region Skane.
AB  - Objectives. Postural orthostatic tachycardia syndrome (POTS) is characterized by cardiovascular autonomic dysfunction of unknown etiology with high a prevalence of gastrointestinal symptoms. The aim of the present study was to examine sociodemographic, lifestyle, and nutritional factors as well as inflammatory markers in patients with POTS. Materials and Methods. Forty-three patients with POTS and 61 healthy controls completed questionnaires about sociodemographic factors, lifestyle habits, and gastrointestinal symptoms. Blood samples were analyzed for serum levels of cobalamins, folic acid, iron, total iron-binding capacity (TIBC), ferritin, sodium, potassium, magnesium, phosphorus, albumin, high-sensitive C-reactive protein (CRP), and 25-hydroxyvitamin D (25-OH vitamin D). Results. POTS patients were predominantly women with a lower education level and were more often working part-time, on sick leave, and living alone compared with healthy controls. They reported lower alcohol intake and physical activity levels than controls. The nutrient intake was in general similar in both groups, but POTS patients had a higher intake of different drinks and reported more gastrointestinal symptoms than controls. POTS was associated with higher CRP levels (beta: 1.370; 95% CI: 0.004-2.737; p=0.049), lower albumin levels (beta: -1.443; 95% CI: -2.648-(-0.238); p=0.019), and higher sodium levels (beta: 1.392; 95% CI: 0.559-2.225; p=0.001). Abdominal pain (p=0.004) and intestinal symptoms' influence on daily life (p=0.025) were negatively associated with albumin levels. Abdominal pain (p=0.011), vomiting and nausea (p=0.003), and intestinal symptoms' influence on daily life (p=0.026) were associated with higher sodium levels. Serum levels representing iron and vitamin metabolism were equal between groups. Conclusions. POTS is associated with poorer sociodemographic status, but malnutrition cannot explain POTS or related gastrointestinal symptoms. Higher CRP and lower albumin levels suggest low-grade inflammation as one possible etiological factor.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Xu, Bingdong
AU  - Xin, Xiufeng
AU  - Ding, Yan
AU  - Xu, Anding
AU  - Zhang, Yusheng
TI  - Effect of Dual- versus Single-Antiplatelet Therapy on Early Neurological Deterioration in Minor Stroke of Undetermined Cause
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2023
PY  - 2023
PG  - 7
SN  - 0001-6314
DO  - 10.1155/2023/5532467
UR  - https://m2.mtmt.hu/api/publication/34628768
ID  - 34628768
N1  - Export Date: 28 February 2024; CODEN: ANRSA
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jannone-Pedro, Nicolas
AU  - Hampel, Kevin G.
AU  - Garces-Sanchez, Mercedes
AU  - Conde-Sardon, Rebeca
AU  - Gutierrez-Martin, Antonio
AU  - Villanueva, Vicente
TI  - Candidate Selection for Implantation: Noninvasive Predictors of Seizure Onset Zone Focality and Surgical Outcome in People with Drug-Resistant Epilepsy Evaluated by Intracranial Video-EEG Monitoring-A Retrospective Cohort Study
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2023
PY  - 2023
PG  - 11
SN  - 0001-6314
DO  - 10.1155/2023/3455061
UR  - https://m2.mtmt.hu/api/publication/34585999
ID  - 34585999
N1  - Refractory Epilepsy Unit, Neurology Service, Member of ERN EpiCARE, University Hospital la Fe, Valencia, Spain            
            Refractory Epilepsy Unit, Neurosurgery Service, Member of ERN EpiCARE, University Hospital la Fe, Valencia, Spain            
            Export Date: 26 July 2024            
            CODEN: ANRSA            
            Correspondence Address: Jannone-Pedro, N.; Refractory Epilepsy Unit, Spain; email: nijanpe@gmail.com
AB  - Objectives. People with drug-resistant epilepsy are potential candidates for epilepsy surgery, a subset of whom requires intracranial video-EEG monitoring (IVEM) to determine the seizure onset zone (SOZ). The purpose of this study is to investigate noninvasive predictors of SOZ focality and surgical outcome in order to optimise case selection for this procedure. Materials and Methods. We performed a retrospective cohort study of patients who underwent IVEM at our centre from January 2006 to July 2021. We applied a multivariate logistic regression model to estimate the effect of potential noninvasive data as influencing factors for both SOZ focality and surgical outcome. A focal SOZ included a sublobar onset on IVEM, and a good surgical outcome was defined as Engel class I. Results. A total of 783 underwent a presurgical evaluation, 102 of them with IVEM. Ninety-seven patients were included in the SOZ focality analysis, and 64 were included in the surgical outcome analysis. The presence of focal to bilateral tonic-clonic seizures (p=0.03) and generalised interictal epileptiform discharges (IEDs) during scalp EEG (p=0.02) predicted a nonfocal SOZ. A weekly (p=0.01) or daily seizure frequency (p<0.01), focal to bilateral tonic-clonic seizures (p=0.01), nonlesional MRI (p<0.01), and multifocal (p=0.02) or generalised IEDs (p<0.01) were associated with a poor surgical outcome. Conclusions. A high seizure frequency, positive history of focal to bilateral tonic-clonic seizures, nonlesional MRI, and generalised and multifocal IEDs are noninvasive factors that may aid in selecting candidates for IVEM.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bhan, A.
AU  - Jacobsen, C.
AU  - Dalen, I.
AU  - Alves, G.
AU  - Bergsland, N.
AU  - Myhr, K.-M.
AU  - Zetterberg, H.
AU  - Zivadinov, R.
AU  - Farbu, E.
TI  - Neurofilament and Brain Atrophy and Their Association with Cognition in Multiple Sclerosis: A 10-Year Follow-Up Study
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2023
PY  - 2023
SN  - 0001-6314
DO  - 10.1155/2023/7136599
UR  - https://m2.mtmt.hu/api/publication/34572643
ID  - 34572643
N1  - Neuroscience Research Group, Department of Neurology, Stavanger University Hospital, Stavanger, Norway            
            Department of Clinical Medicine, University of Bergen, Bergen, Norway            
            Section of Biostatistics, Department of Research, Stavanger University Hospital, Stavanger, Norway            
            Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States            
            Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway            
            Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden            
            Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom            
            Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden            
            UK Dementia Research Institute, UCL, London, United Kingdom            
            Hong Kong Center for Neurodegenerative Diseases, Hong Kong, Hong Kong            
            Center for Biomedical Imaging, Clinical Translational Science Institute, University at Buffalo, Buffalo, NY, United States            
            Export Date: 12 February 2024            
            CODEN: ANRSA            
            Correspondence Address: Bhan, A.; Neuroscience Research Group, Norway; email: alok.bhan@gmail.com            
            Tradenames: NF light Elisa kit, uman diagnostics ab, Sweden; simoa, Quanterix, United States; SPSS Statistics for Windows Version 26.0, IBM, United States; StataCorp 2021, StataCorp, United States            
            Manufacturers: IBM; IBM, United States; Quanterix; Quanterix, United States; Siemens; StataCorp; uman diagnostics ab, Sweden; StataCorp, United States; uman diagnostics ab
AB  - Introduction. Cognitive impairment is an important contributor to disability in multiple sclerosis (MS). Disconnection of neuronal circuits due to axonal injury is probably an important underlying mechanism for this disability. Neurofilament light chain (NfL) is a neuron-specific constituent of axons and has gained increasing attention as a biomarker of axonal injury. Objective. To assess the association between NfL in serum (sNfL) and cerebrospinal fluid (cNfL) and cognitive function over 10 years and compare these associations with volumetric brain magnetic resonance imaging (MRI) measurements. Methods. Newly diagnosed MS patients were followed prospectively with baseline NfL and MRI as well as with clinical and cognitive assessments for up to 10 years. Results. Forty-one patients were included. Baseline sNfL correlated negatively with symbol digit modalities test (SDMT) at baseline (r=-0.45, p=0.005), year 5 (r=-0.41, p=0.017), and at year 10 (r=-0.52, p=0.008). Baseline cNfL correlated with baseline SDMT (r=-0.34, p=0.030) and SDMT at year 10 (r=-0.44, p=0.037). Baseline volumes of whole brain (r=0.476, p=0.002), gray matter (r=0.467, p=0.002), T1 (r=-0.627, p<0.001), and T2 lesion volumes (r=-0.475, p=0.002) correlated significantly with baseline SDMT. Longitudinal analyses showed that both MRI volumes and EDSS were associated with the rate of SDMT decline, whereas sNfL and cNfL were not. Conclusion. NfL levels measured in serum and cerebrospinal fluid were both associated with cognitive functioning in MS patients over a 10-year period from diagnosis. However, MRI volumes correlated strongly in addition to the rate of cognitive decline. © 2023 Alok Bhan et al.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Amarjeet, Abhipsa
AU  - Babu, Raja
AU  - Mohapatra, Abhipsa
AU  - Pancholi, Bhaskaranand
AU  - Garabadu, Debapriya
AU  - Sharma, Anjali
AU  - Sharma, Ashwani
AU  - Azad, Md. A. K.
TI  - Understanding the Cross-Talk between the Ceramide Biosynthetic Pathway and Mitochondrial Function in Multiple Sclerosis and Demyelinating Disorders
JF  - ACTA NEUROLOGICA SCANDINAVICA
J2  - ACTA NEUROL SCAND
VL  - 2023
PY  - 2023
PG  - 17
SN  - 0001-6314
DO  - 10.1155/2023/7398037
UR  - https://m2.mtmt.hu/api/publication/34309252
ID  - 34309252
N1  - Export Date: 28 November 2023; CODEN: ANRSA
AB  - Myelin is a spiral compilation of uniformly thick membranes around the axon in an alternating fashion, and it is formed by a complicated process known as myelination. Myelin sheaths are responsible for various physiological functions such as metabolism, rapid nerve conduction, and maintaining ionic and water homeostasis in the brain. Lipid is one of the major components in the myelin, which includes cholesterol, ceramide, and their derivatives, such as galactosylceramide, sulfatide, and gangliosides. Ceramide and its derivatives are synthesised by various ceramide biosynthetic pathways such as de novo, salvage, sphingomyelinase, and recycling of exogenous ceramide. At an appropriate level, ceramide facilitates the development of the nervous system, cell proliferation, autophagy, and apoptosis, which are responsible for normal functioning, but when the level is altered from normal, it results in mitochondrial dysfunction or cell death through autophagy and apoptosis. The ceramide level increases, especially in the mitochondria. Ceramide level increases in response to oxidative stress which is mediated by inflammatory cytokines. Due to mitochondrial dysfunction, an energy-deficient condition is created because of disruption in the electron transport chain, which results in the death of neurons and glial cells, which subsequently cause demyelination and degeneration of axon. Losing myelin while axons remain relatively intact is the characteristic feature of demyelinating diseases. The primary element of demyelinating disorder is damage, malfunction, failure, or death of mitochondria. These disturbances may occur due to direct or indirect interaction of ceramide with mitochondria. There are several risk factors for demyelination, such as viruses, bacteria, fungi, trauma, obesity, vitamin D deficiency, and genetic and environmental factors. Thus, the review is mainly aimed towards the interaction between ceramide and mitochondria during demyelination.
LA  - English
DB  - MTMT
ER  -