@article{MTMT:34566742, title = {The Role of Biomarkers Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Vasoactive Intestinal Peptide (VIP) in Chronic and Episodic Migraines: A Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/34566742}, author = {Thapa, S. and Shah, S. and Bhattarai, A. and Yadav, R. and Yu, F. and Chand, S. and Li, J.}, doi = {10.1155/2024/2954374}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, volume = {2024}, unique-id = {34566742}, issn = {0001-6314}, abstract = {Background. Migraine is a neurological disorder that results in disability accumulation, and there are no blood-based markers for indicating migraine susceptibility. Here, we aimed to evaluate the possible biomarker role of neuropeptides, vasoactive intestinal peptide (VIP), and pituitary adenylate cyclase-activating polypeptide (PACAP) in chronic (CM) and episodic migraine (EM). Method. PubMed, medRxiv, and Google Scholar databases were searched up to the 7th of September 2022 using the search syntax to define all relevant articles addressing the plasma and serum levels of VIP and PACAP in migraineurs and controls. Concerning bias assessment, the risk of bias in nonrandomized studies-I (ROBINS-I) was assessed. Also, the standardized mean difference (SMD) was measured with a random effects model. Results. Five case-control studies with 503 migraine cases were included. CM patients had elevated VIP levels compared to controls (SMD=0.44, 95% CI 0.25-0.62, p<0.00001). In contrast, PACAP levels were lower in EM patients (SMD=-0.30, 95% CI -0.48 to -0.11, p=0.002). Overall, migraine cases had higher VIP levels (SMD=0.25, 95% CI 0.11-0.39, p=0.0006) but lower PACAP levels (SMD=-0.16, 95% CI -0.30 to -0.03, p=0.020) than controls. Conclusion. The results support the role of VIP and PACAP neuropeptides in migraine pathophysiology. CM patients have significantly higher serum VIP levels, while EM patients have lower serum PACAP levels compared to controls. Further studies should confirm these findings. © 2024 Sangharsha Thapa et al.}, keywords = {Adult; Female; Male; NEUROPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE; review; human; controlled study; protein blood level; meta analysis; hypophysis adenylate cyclase activating polypeptide; EPISODIC MIGRAINE; transformed migraine}, year = {2024}, eissn = {1600-0404} } @article{MTMT:34628768, title = {Effect of Dual- versus Single-Antiplatelet Therapy on Early Neurological Deterioration in Minor Stroke of Undetermined Cause}, url = {https://m2.mtmt.hu/api/publication/34628768}, author = {Xu, Bingdong and Xin, Xiufeng and Ding, Yan and Xu, Anding and Zhang, Yusheng}, doi = {10.1155/2023/5532467}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, volume = {2023}, unique-id = {34628768}, issn = {0001-6314}, year = {2023}, eissn = {1600-0404} } @article{MTMT:34585999, title = {Candidate Selection for Implantation: Noninvasive Predictors of Seizure Onset Zone Focality and Surgical Outcome in People with Drug-Resistant Epilepsy Evaluated by Intracranial Video-EEG Monitoring-A Retrospective Cohort Study}, url = {https://m2.mtmt.hu/api/publication/34585999}, author = {Jannone-Pedro, Nicolas and Hampel, Kevin G. and Garces-Sanchez, Mercedes and Conde-Sardon, Rebeca and Gutierrez-Martin, Antonio and Villanueva, Vicente}, doi = {10.1155/2023/3455061}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, volume = {2023}, unique-id = {34585999}, issn = {0001-6314}, abstract = {Objectives. People with drug-resistant epilepsy are potential candidates for epilepsy surgery, a subset of whom requires intracranial video-EEG monitoring (IVEM) to determine the seizure onset zone (SOZ). The purpose of this study is to investigate noninvasive predictors of SOZ focality and surgical outcome in order to optimise case selection for this procedure. Materials and Methods. We performed a retrospective cohort study of patients who underwent IVEM at our centre from January 2006 to July 2021. We applied a multivariate logistic regression model to estimate the effect of potential noninvasive data as influencing factors for both SOZ focality and surgical outcome. A focal SOZ included a sublobar onset on IVEM, and a good surgical outcome was defined as Engel class I. Results. A total of 783 underwent a presurgical evaluation, 102 of them with IVEM. Ninety-seven patients were included in the SOZ focality analysis, and 64 were included in the surgical outcome analysis. The presence of focal to bilateral tonic-clonic seizures (p=0.03) and generalised interictal epileptiform discharges (IEDs) during scalp EEG (p=0.02) predicted a nonfocal SOZ. A weekly (p=0.01) or daily seizure frequency (p<0.01), focal to bilateral tonic-clonic seizures (p=0.01), nonlesional MRI (p<0.01), and multifocal (p=0.02) or generalised IEDs (p<0.01) were associated with a poor surgical outcome. Conclusions. A high seizure frequency, positive history of focal to bilateral tonic-clonic seizures, nonlesional MRI, and generalised and multifocal IEDs are noninvasive factors that may aid in selecting candidates for IVEM.}, year = {2023}, eissn = {1600-0404} } @article{MTMT:34572643, title = {Neurofilament and Brain Atrophy and Their Association with Cognition in Multiple Sclerosis: A 10-Year Follow-Up Study}, url = {https://m2.mtmt.hu/api/publication/34572643}, author = {Bhan, A. and Jacobsen, C. and Dalen, I. and Alves, G. and Bergsland, N. and Myhr, K.-M. and Zetterberg, H. and Zivadinov, R. and Farbu, E.}, doi = {10.1155/2023/7136599}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, volume = {2023}, unique-id = {34572643}, issn = {0001-6314}, abstract = {Introduction. Cognitive impairment is an important contributor to disability in multiple sclerosis (MS). Disconnection of neuronal circuits due to axonal injury is probably an important underlying mechanism for this disability. Neurofilament light chain (NfL) is a neuron-specific constituent of axons and has gained increasing attention as a biomarker of axonal injury. Objective. To assess the association between NfL in serum (sNfL) and cerebrospinal fluid (cNfL) and cognitive function over 10 years and compare these associations with volumetric brain magnetic resonance imaging (MRI) measurements. Methods. Newly diagnosed MS patients were followed prospectively with baseline NfL and MRI as well as with clinical and cognitive assessments for up to 10 years. Results. Forty-one patients were included. Baseline sNfL correlated negatively with symbol digit modalities test (SDMT) at baseline (r=-0.45, p=0.005), year 5 (r=-0.41, p=0.017), and at year 10 (r=-0.52, p=0.008). Baseline cNfL correlated with baseline SDMT (r=-0.34, p=0.030) and SDMT at year 10 (r=-0.44, p=0.037). Baseline volumes of whole brain (r=0.476, p=0.002), gray matter (r=0.467, p=0.002), T1 (r=-0.627, p<0.001), and T2 lesion volumes (r=-0.475, p=0.002) correlated significantly with baseline SDMT. Longitudinal analyses showed that both MRI volumes and EDSS were associated with the rate of SDMT decline, whereas sNfL and cNfL were not. Conclusion. NfL levels measured in serum and cerebrospinal fluid were both associated with cognitive functioning in MS patients over a 10-year period from diagnosis. However, MRI volumes correlated strongly in addition to the rate of cognitive decline. © 2023 Alok Bhan et al.}, keywords = {Adult; Female; Male; SERUM; ARTICLE; human; comparative study; disease association; controlled study; cohort analysis; clinical feature; nuclear magnetic resonance imaging; clinical article; cognition; cerebrospinal fluid; prospective study; MULTIPLE SCLEROSIS; BRAIN ATROPHY; follow up; Neurofilament; clinical assessment; cognitive defect; MILD COGNITIVE IMPAIRMENT; gray matter; nerve cell network; Demographics; AXONAL INJURY; neurofilament light chain; Symbol Digit Modalities Test; lesion volume; T1 weighted imaging; T2 weighted imaging}, year = {2023}, eissn = {1600-0404} } @article{MTMT:34309252, title = {Understanding the Cross-Talk between the Ceramide Biosynthetic Pathway and Mitochondrial Function in Multiple Sclerosis and Demyelinating Disorders}, url = {https://m2.mtmt.hu/api/publication/34309252}, author = {Amarjeet, Abhipsa and Babu, Raja and Mohapatra, Abhipsa and Pancholi, Bhaskaranand and Garabadu, Debapriya and Sharma, Anjali and Sharma, Ashwani and Azad, Md. A. K.}, doi = {10.1155/2023/7398037}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, volume = {2023}, unique-id = {34309252}, issn = {0001-6314}, abstract = {Myelin is a spiral compilation of uniformly thick membranes around the axon in an alternating fashion, and it is formed by a complicated process known as myelination. Myelin sheaths are responsible for various physiological functions such as metabolism, rapid nerve conduction, and maintaining ionic and water homeostasis in the brain. Lipid is one of the major components in the myelin, which includes cholesterol, ceramide, and their derivatives, such as galactosylceramide, sulfatide, and gangliosides. Ceramide and its derivatives are synthesised by various ceramide biosynthetic pathways such as de novo, salvage, sphingomyelinase, and recycling of exogenous ceramide. At an appropriate level, ceramide facilitates the development of the nervous system, cell proliferation, autophagy, and apoptosis, which are responsible for normal functioning, but when the level is altered from normal, it results in mitochondrial dysfunction or cell death through autophagy and apoptosis. The ceramide level increases, especially in the mitochondria. Ceramide level increases in response to oxidative stress which is mediated by inflammatory cytokines. Due to mitochondrial dysfunction, an energy-deficient condition is created because of disruption in the electron transport chain, which results in the death of neurons and glial cells, which subsequently cause demyelination and degeneration of axon. Losing myelin while axons remain relatively intact is the characteristic feature of demyelinating diseases. The primary element of demyelinating disorder is damage, malfunction, failure, or death of mitochondria. These disturbances may occur due to direct or indirect interaction of ceramide with mitochondria. There are several risk factors for demyelination, such as viruses, bacteria, fungi, trauma, obesity, vitamin D deficiency, and genetic and environmental factors. Thus, the review is mainly aimed towards the interaction between ceramide and mitochondria during demyelination.}, year = {2023}, eissn = {1600-0404} } @article{MTMT:34187035, title = {Multiple Sclerosis and Suicide Attempts: A Review including a Meta-Analysis of Prevalence}, url = {https://m2.mtmt.hu/api/publication/34187035}, author = {D'Andrade, T.B. and Larsen, C.P. and Stenager, E. and Stenager, E.N. and Christiansen, E.}, doi = {10.1155/2023/1067257}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, volume = {2023}, unique-id = {34187035}, issn = {0001-6314}, year = {2023}, eissn = {1600-0404} } @article{MTMT:33876707, title = {Verified Parental Cardiovascular Events for Young and Middle-Aged Ischaemic Stroke Patients and Controls}, url = {https://m2.mtmt.hu/api/publication/33876707}, author = {Boland, Solveig and Nawaz, Beenish and Oygarden, Halvor and Fromm, Annette and Naess, Halvor and Waje-Andreassen, Ulrike}, doi = {10.1155/2023/3864506}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, volume = {2023}, unique-id = {33876707}, issn = {0001-6314}, abstract = {Introduction. Nonmodifiable cardiovascular risk factors, like age and sex, are easily quantifiable. Due to immense technical progress in diagnostics and medical data storage, the aim of this study was to quantify, verify, and to compare parental cardiovascular events (CVE) as an additional nonmodifiable risk factor for young and middle-aged ischaemic stroke patients and controls. Methods. Information about parental CVE was first obtained by standardized questionnaires answered by 385 acute ischaemic stroke patients (15-60 years of age) and 260 controls. After consent to contact living and include deceased parents, patients and controls provided necessary personal identification of their parents. Thereafter, CVE were verified by standardized questionnaires answered by parents or medical records in case of deceased parents. Results. One hundred-and-nine (14.2%) of 770 patient parents vs. 128 (24.6%) of 520 control parents were not available for verification. Active participation was obtained for 229 (73.9%) of 310 patient parents vs.113 (58.2%) of 194 control parents. Medical record verification was obtained for 192 (54.7%) of 351 deceased patient parents, vs.103 (52.0%) of 198 deceased control parents. This study showed highest death rates of fathers (65.3% patient fathers and 57.6% control fathers) and highest numbers of CVE, especially myocardial infarction among patient fathers of patients aged 50-60 years. Discussion and Conclusion. Obtaining verified parental CVE as a nonmodifiable risk factor is still challenging, despite widely available digital medical information. To attain more accurate information on parental CVE, we recommend active involvement of family members in addition to medical record verification, especially for patients aged Trial Registration.}, year = {2023}, eissn = {1600-0404} } @article{MTMT:33188617, title = {Seizure detection based on wearable devices: A review of device, mechanism, and algorithm}, url = {https://m2.mtmt.hu/api/publication/33188617}, author = {Li, W. and Wang, G. and Lei, X. and Sheng, D. and Yu, T. and Wang, G.}, doi = {10.1111/ane.13716}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, unique-id = {33188617}, issn = {0001-6314}, year = {2022}, eissn = {1600-0404} } @article{MTMT:32945546, title = {Prehospital triage optimization of patients with large vessel occlusion by Austrian Prehospital Stroke Scale}, url = {https://m2.mtmt.hu/api/publication/32945546}, author = {Krebs, Stefan and Sykora, Marek and Krammel, Mario and Girsa, Michael and Auer, Alexander and Greisenegger, Stefan and Neumann, Christian and Beisteiner, Roland and Lang, Wilfried and Roth, Dominik}, doi = {10.1111/ane.13654}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, unique-id = {32945546}, issn = {0001-6314}, abstract = {Objectives The Austrian Prehospital Stroke Scale (APSS) score was developed to predict large vessel occlusion (LVO) and improve prehospital transportation triage. Its accuracy has been previously analyzed retrospectively. We now aimed to investigate the accuracy, as well as the impact of the implementation of a triage strategy using this score on treatment times and outcome in a prospective study. Matherial & Methods Prospective diagnostic test accuracy and before-after interventional study. EMS prospectively evaluated APSS in patients suspected of stroke. Accuracy was compared with other LVO scores. Patients with APSS >= 4 points were brought directly to the comprehensive stroke center. Treatment time frames, neurological, and radiological outcome before and after the APSS implementation were compared. Results A total of 307 patients with suspected stroke were included from October 2018 to February 2020. Treatable LVO was present in 79 (26%). Sensitivity of APSS to detect those was 90%, specificity 79%, positive predictive value 66%, negative predictive value 95%, and area under the curve 0.87 (95% CI 0.83-0.91). This was similar to in-hospital NIHSS (AUC 0.89 95% CI 0.89-0.92, p = .06) and superior to CPSS (AUC 0.83 95% CI 0.78-0.87, p = .01). Implementation of APSS triage increased direct transportation rate for LVO patients (21% before vs. 52% after; p < .001) with a significant time benefit (alert to groin puncture time benefit: 51 min (95% CI 28-74; p < .001). Neurological and radiological outcome did not differ significantly. Conclusions Austrian Prehospital Stroke Scale triage showed an accuracy comparable with in-hospital NIHSS, and lead to a significant optimization of prehospital workflows in patients with potential LVO.}, keywords = {Acute ischaemic stroke; prehospital stroke care; FAST test; LVO screen}, year = {2022}, eissn = {1600-0404} } @article{MTMT:32945536, title = {Methodological survey of missing outcome data in an alteplase for ischemic stroke meta-analysis}, url = {https://m2.mtmt.hu/api/publication/32945536}, author = {Garg, Ravi}, doi = {10.1111/ane.13656}, journal-iso = {ACTA NEUROL SCAND}, journal = {ACTA NEUROLOGICA SCANDINAVICA}, unique-id = {32945536}, issn = {0001-6314}, abstract = {Objective Recent national guidelines recommend alteplase treatment for ischemic stroke within 4.5 h of symptom-onset based on meta-analyses of randomized controlled clinical trials (RCT). A detailed description of missing outcome data (MOD) due to participant loss to follow-up has never been published. The objective of this study was to perform a methodlogical survey on missing outcome data in an alteplase for ischemic stroke meta-analysis. Materials and Methods A methodological survey was performed on a chosen meta-analysis of alteplase for ischemic stroke RCTs that most closely aligns with recent national guideline recommendations. Data were collected to assess the number of participants lost to follow-up; differential lost to follow-up between allocation groups; baseline characteristics of those lost to follow-up; and the imputation methods used by individual trials and the chosen meta-analysis. The number of participants lost to follow-up was compared with the fragility index; and repeated for individually positive RCTs in the meta-analysis. Results The methodological survey revealed a substantial degree of missing information regarding MOD in the chosen meta-analysis and in individual RCTs. Single imputation was exclusively used in all RCTs and in the meta-analysis. The number of participants lost to follow-up was greater than the fragility index in the chosen meta-analysis and individually positive component RCTs suggesting that MOD may impact the direction of the reported effect or effect size. Conclusion This methodological survey of an alteplase for ischemic stroke meta-analysis revealed MOD may be an important source of unrecognized bias. This survey highlights the need for sensitivity analyses using more robust methods of imputation.}, keywords = {Meta-analysis; ischemic stroke; BIAS; alteplase; missing outcome data}, year = {2022}, eissn = {1600-0404}, orcid-numbers = {Garg, Ravi/0000-0001-9864-8443} }