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            Funding text: The authors were supported by grants from Noncommunicable Chronic Diseases-National Science and Technology Major Project (No. 2025ZD0547800), National Natural Science Foundation of China (No. 82222007, 82170281, 82300395, and U2004203), Henan Province Key R&amp;D Program (No.241111313300), Henan Province Science and Technology Research Joint Project (No. 222301420054), Innovation Scientists and Technicians Troop Construction Projects of Henan Province (No. 254000510006), Henan Provincial Clinical Medical Scientist Training Project (HNCMS202418), Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University (No. ZYCXTD2023008 and QNCXTD2023001).</comment>
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							&lt;span class=&quot;author-name&quot; &gt;Fu Tinglan
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							&lt;span class=&quot;author-name&quot; &gt;Tang Junnan
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&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;36896562&quot; target=&quot;_blank&quot;&gt;Pathological mechanisms and treatment strategies for immune checkpoint inhibitor-associated myocarditis: insights from single-cell sequencing&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;BASIC RESEARCH IN CARDIOLOGY&lt;/span&gt;

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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.04.19. 20:07 Tichy Rita (SE_KK_Admin5_TR, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Funding Agency and Grant Number: Henan Province Science and Technology Research Joint Project [222301420054]; Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University [ZYCXTD2023008, QNCXTD2023001]; Innovation Scientists and Technicians Troop Construction Projects of Henan Province [254000510006]; Noncommunicable Chronic Diseases-National Scie...&lt;/pre&gt;

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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 20 March 2026; Cited By: 0; Correspondence Address: M. Totzeck; Clinic for Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital Essen, Essen, Hufelandstr. 55, 45147, Germany; email: matthias.totzeck@uk-essen.de; CODEN: BRCAB;&lt;/pre&gt;

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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 22 April 2026; Cited By: 0; CODEN: BRCAB;&lt;/pre&gt;

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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.04.22. 19:05 Tichy Rita (SE_KK_Admin5_TR, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 22 April 2026; Cited By: 0; CODEN: BRCAB;&lt;/pre&gt;
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&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;37013928&quot; target=&quot;_blank&quot;&gt;Remote ischemic conditioning protects against anthracycline cardiotoxicity without impairing its antitumor activity&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;BASIC RESEARCH IN CARDIOLOGY&lt;/span&gt;

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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.04.19. 20:43 Tichy Rita (SE_KK_Admin5_TR, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 19 March 2026; Cited By: 0; Correspondence Address: B. Ibáñez; Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain; email: bibanez@cnic.es; CODEN: BRCAB;&lt;/pre&gt;

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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.05.13. 11:04 Szuper Admin (admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 19 April 2026; Cited By: 0; CODEN: BRCAB;&lt;/pre&gt;

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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.04.22. 19:05 Tichy Rita (SE_KK_Admin5_TR, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 22 April 2026; Cited By: 0; CODEN: BRCAB;&lt;/pre&gt;

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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.04.19. 18:39 Tichy Rita (SE_KK_Admin5_TR, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 19 April 2026; Cited By: 0; CODEN: BRCAB;&lt;/pre&gt;

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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.04.19. 20:43 Tichy Rita (SE_KK_Admin5_TR, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 19 April 2026; Cited By: 1; CODEN: BRCAB;&lt;/pre&gt;

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      <abstractText>Therapeutic strategies to limit doxorubicin (DOX)-induced cardiomyopathy are still limited due to incomplete characterization of the underlying molecular mechanisms. The exogenous activation of autophagy was reported to exert cardioprotective effects in preclinical models of cardiovascular diseases. We tested whether restoration of autophagy by different pharmacological approaches can reduce DOX-induced cardiomyopathy. A validated preclinical murine model of DOX-induced cardiotoxicity (final cumulative dose of 15 mg/kg) was used to test the cardiac effects of both natural (trehalose and spermidine) and synthetic (Tat-Beclin 1 D11) activators of autophagy. Cardiac function was evaluated by echocardiographic analyses. We performed histological analyses (Masson trichrome staining, TUNEL assay) to investigate fibrosis and apoptosis. Biomolecular analyses, confocal and transmission electron microscopy were used to assess levels of autophagy, autophagic flux, mitophagy and mitochondrial alterations. We also evaluated the effects of autophagy activators in a validated syngeneic model with subcutaneous injection of breast cancer cells treated with DOX. We found that DOX-induced cardiotoxicity is associated with impaired autophagic flux (accumulation of LC3-II and p62). Reactivation of autophagic flux by trehalose or spermidine rescues cardiac function and cardiomyocyte survival in mice treated with DOX, along with an overall amelioration of mitochondrial health and mitophagy. Selective reactivation of autophagy by Tat-Beclin 1 D11 also recapitulates the protective effects exerted by trehalose and spermidine. Autophagy activators preserve cardiac function without affecting the antineoplastic effects of DOX in mice with cancer. Boosting autophagic flux is a suitable therapeutic approach to prevent cardiotoxicity induced by anthracyclines.</abstractText>
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PubMed &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;div class=&quot;publication-citation&quot;&gt; &lt;a target=&quot;_blank&quot; href=&quot;/api/publication?cond=citations.related;eq;37082148&amp;sort=publishedYear,desc&amp;sort=title&quot;&gt; Idézett közlemények száma: 1 &lt;/a&gt; &lt;/div&gt; &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 37082148&lt;/span&gt; | &lt;span class=&quot;status-data status-APPROVED&quot;&gt; Nyilvános &lt;/span&gt; Idéző | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk ( Szakcikk ) &lt;/span&gt; | &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt; | &lt;span class=&quot;publication-sourceOfData&quot;&gt;WOS TAGGED&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.04.19. 20:55 Tichy Rita (SE_KK_Admin5_TR, admin) &lt;/div&gt; &lt;/div&gt;&lt;/div&gt;</template2>
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