TY  - JOUR
AU  - Tóth, Barbara
AU  - Horváth, Attila
AU  - Jójártné Laczkovich, Orsolya
AU  - Biró, Dalma
AU  - Matuz, Mária
AU  - Csupor, Dezső
TI  - Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
PY  - 2024
SN  - 0032-0943
DO  - 10.1055/a-2283-8147
UR  - https://m2.mtmt.hu/api/publication/34728728
ID  - 34728728
N1  - Funding Agency and Grant Number: Ministry of Innovation and Technology of Hungary [TKP2021-EGA, TKP2021-EGA-32]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund
            Funding text: This work was supported by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme; project No. TKP2021-EGA-32 has been implemented with the support provided.
AB  - Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, plastic container). 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease of 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Li, Y.
AU  - Ji, N.
AU  - Wang, M.
AU  - Pugh, N.D.
AU  - Khan, I.A.
AU  - Tan, C.
TI  - Immulina as an Immunostimulatory Supplement: Formulation and Pharmacological Studies
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
PY  - 2023
SN  - 0032-0943
DO  - 10.1055/a-2156-4653
UR  - https://m2.mtmt.hu/api/publication/34170092
ID  - 34170092
N1  - Department of Pharmaceutics and Drug Delivery, University of Mississippi, UniversityMS, United States            
            National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, UniversityMS, United States            
            Department of BioMolecular Sciences, University of Mississippi, UniversityMS, United States            
            Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, TN, United States            
            Export Date: 3 October 2023            
            CODEN: PLMEA            
            Correspondence Address: Tan, C.; Department of Pharmaceutical Sciences, 881 Madison Avenue, United States; email: ctan5@uthsc.edu
AB  - Immulina is a commercially available extract of Arthrospira platensis enriched with bacterial lipoproteins that acts as a potent Toll-like receptor 2 agonist. However, the immunostimulatory effect of Immulina is not well understood in vivo. Here, to devise an Immulina formulation suitable for in vivo oral gavage dosing, Immulina nanosuspension was prepared and freeze-dried to yield lyophilized nano-Immulina, which had an average particle size of around 300 nm and fully retained the bioactivity as a Toll-like receptor 2 agonist. Compared to the regular Immulina powder, lyophilized nano-Immulina notably accelerated the dissolution in aqueous media. Immulina nanosuspension was found to stimulate the production of proinflammatory cytokines in murine bone marrow-derived dendritic cells and macrophages. The immune response to Immulina was investigated in healthy mice by longitudinally monitoring the phagocytic activity of circulating neutrophils as a surrogate marker. Following daily oral ingestion of Immulina nanosuspension (10 mg/mouse/day), the phagocytic activity of circulating neutrophils was significantly elevated, suggesting an important mechanism for Immulina to enhance innate immunity. © 2023 Georg Thieme Verlag. All rights reserved.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Wawrosch, C.
AU  - Oberhofer, M.
AU  - Steinbrecher, S.
AU  - Zotchev, S.B.
TI  - Impact of Phylogenetically Diverse Bacterial Endophytes of Bergenia pacumbis on Bergenin Production in the Plant Cell Suspension Cultures
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
PY  - 2023
SN  - 0032-0943
DO  - 10.1055/a-2162-4018
UR  - https://m2.mtmt.hu/api/publication/34149122
ID  - 34149122
AB  - Plant in vitro cultures are potential sources for secondary metabolites. However, low productivity is often a major drawback for industrial application. Elicitation is an important strategy to improve product formation in vitro. In this context, endophytes are of special interest as biotic elicitors due to their possible interaction with the metabolism of the host plant. A total of 128 bacterial endophytes were isolated from the medicinal plant Bergenia pacumbis and taxonomically classified using 16S rRNA gene sequencing. Five strains belonging to different genera were grown in lysogeny broth and tryptic soy broth medium and cells as well as spent media were used as elicitors in cell suspension cultures of B. pacumbis. Production of the main bioactive compound bergenin was enhanced 3-fold (964 μg/g) after treatment with cells of Moraxella sp. or spent tryptic soy broth medium of Micrococcus sp. These results indicate that elicitation of plant cell suspension cultures with endophytic bacteria is a promising strategy for enhancing the production of desired plant metabolites. © 2023 Georg Thieme Verlag. All rights reserved.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Grifoni, L.
AU  - Vanti, G.
AU  - Vannucchi, M.G.
AU  - Bergonzi, M.C.
AU  - Bilia, A.R.
TI  - Development and Evaluation of Khellin-loaded Microemulgel for Dermatological Applications
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
VL  - 89
PY  - 2023
SP  - 848
EP  - 855
PG  - 8
SN  - 0032-0943
DO  - 10.1055/a-1789-3112
UR  - https://m2.mtmt.hu/api/publication/33675095
ID  - 33675095
N1  - Department of Chemistry, University of Florence, Florence, Italy            
            Section of Histology and Embryology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy            
            Cited By :1            
            Export Date: 1 March 2023            
            CODEN: PLMEA            
            Correspondence Address: Bilia, A.R.; Department of Chemistry, via U. Schiff 6, Sesto Fiorentino, Italy; email: ar.bilia@unifi.it
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Karadağ, Ayşe Esra
AU  - Çaşkurlu, Ayşegül
AU  - Demirci, Betül
AU  - Demirci, Fatih
TI  - Binary Synergistic Combinations of Lavender and Fennel Essential Oils with Amoxicillin
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
VL  - 89
PY  - 2023
IS  - 8
SP  - 800
EP  - 807
PG  - 8
SN  - 0032-0943
DO  - 10.1055/a-1891-1119
UR  - https://m2.mtmt.hu/api/publication/33041483
ID  - 33041483
AB  - Microbial resistance is an important problem in modern healthcare systems. In addition to drug resistance, the side effects of current antibiotic applications are also known issues. In this present study, binary combinations of amoxicillin with European Pharmacopoeia quality lavender (Lavandula angustifolia) and fennel (Foeniculum vulgare) essential oils were evaluated against human pathogenic microbial strains. The checkerboard method was used to quantify the efficacy of essential oils in combination with amoxicillin. As an initial result, remarkable in vitro antimicrobial activity was observed at relatively low amoxicillin concentrations using different oil combinations against Staphylococcus aureus ATCC 6538, Enterococcus faecalis ATCC 29212, Bacillus cereus ATCC 14579, and Escherichia coli NRRL B-3008, Salmonella typhi (Clinical isolate), respectively. Fractional inhibitory concentrations (FIC) were calculated and interpreted in terms of addition, synergy, antagonism, or indifferent, respectively. A synergistic interaction was shown for E. faecalis and E. coli with the combination F. vulgare essential oil and amoxicillin (FICI= 8.05 x 10-4). Both essential oils together, and in combination with amoxicillin showed a synergistic effect as well.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hong, Zhou
AU  - Zhou, Li-Shuang
AU  - Zhao, Zhi-Zhi
AU  - Yuan, Guo-Qi
AU  - Wang, Xiao-Jiang
AU  - Lu, Yan
AU  - Chen, Dao-Feng
TI  - Structural Characterization and Anticomplement Activity of an Acidic Heteropolysaccharide from Lysimachia christinae Hance
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
VL  - 89
PY  - 2023
IS  - 15
SP  - 1457
EP  - 1467
PG  - 11
SN  - 0032-0943
DO  - 10.1055/a-2148-7163
UR  - https://m2.mtmt.hu/api/publication/34313835
ID  - 34313835
AB  - A novel acidic heteropolysaccharide (LCP-90-1) was isolated and purified from a traditional "heat-clearing" Chinese medicine, Lysimachia christinae Hance. LCP-90-1 ( Mw , 20.65 kDa) was composed of Man, Rha, GlcA, Glc, Gal, and Ara, with relative molar ratios of 1.00: 3.00: 11.62: 1.31: 1.64: 5.24. The backbone consisted of 1,4- alpha -D-Glc p A, 1,4- alpha -D-Glc p , 1,4- beta -L-Rhap , and 1,3,5- alpha -L-Ara f , with three branches of beta -D-Gal p -(1 -> 4)- beta -L-Rha p -(1 ->, alpha -L-Ara f -(1 -> and alpha -D-Man p -(1 -> attached to the C-5 position of 1,3,5- alpha -L-Ara f . LCP-90-1 exhibited potent anticomplement activity (CH 50 : 135.01 +/- 0.68 mu g/mL) in vitro , which was significantly enhanced with increased glucuronic acid (GlcA) content in its degradation production (LCP-90-1-A, CH50 : 28.26 +/- 0.39 mu g/mL). However, both LCP-90-1 and LCP90-1-A were inactivated after reduction or complete acid hydrolysis. These observations indicated the important role of GlcA in LCP-90-1 and associated derivatives with respect to anticomplement activity. Similarly, compared with LCP-90-1, the antioxidant activity of LCP-90-1-A was also enhanced. Thus, polysaccharides with a high content of GlcA might be important and effective substances of L. christinae .
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zold, Eszter Laczko
AU  - Koreh, Beata
AU  - Jakab-Farkas, Laszlo
AU  - Domokos, Erzsébet
TI  - Analysis of pollen in "handmade" honey samples from the central microregion of Romania by scanning electron microscopy
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
VL  - 89
PY  - 2023
IS  - 14
SP  - 1401
EP  - 1401
PG  - 1
SN  - 0032-0943
DO  - 10.1055/s-0043-1774199
UR  - https://m2.mtmt.hu/api/publication/34741172
ID  - 34741172
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zold, Eszter Laczko
AU  - Stefanescu, Ruxandra
AU  - Vancea, Szende
AU  - Domokos, Erzsébet
TI  - Volatile compounds from Heracleum sphondylium L. Leaves and Fruits as identified by GC/MS
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
VL  - 89
PY  - 2023
IS  - 14
SP  - 1357
EP  - 1357
PG  - 1
SN  - 0032-0943
DO  - 10.1055/s-0043-1774058
UR  - https://m2.mtmt.hu/api/publication/34741171
ID  - 34741171
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zold, Eszter Laczko
AU  - Darko, Bela
AU  - Domokos, Erzsébet
TI  - Secretory tissues from Heracleum sphondylium L. fruits in different maturity stages
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
VL  - 89
PY  - 2023
IS  - 14
SP  - 1352
EP  - 1352
PG  - 1
SN  - 0032-0943
DO  - 10.1055/s-0043-1774040
UR  - https://m2.mtmt.hu/api/publication/34741167
ID  - 34741167
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kragl, Martin
AU  - Neubauer, Christine
AU  - Moritz, Kathrin
AU  - Ziegler, Ramona
AU  - Maehler, Nicole
AU  - Soeberdt, Michael
AU  - Bonyadirad, Ehsan
AU  - Braun, Theodor
AU  - Filipek, Przemyslaw
AU  - Jakschitz, Thomas
AU  - Koeberle, Andreas
AU  - Bonn, Gunther
AU  - Abels, Christoph
TI  - A combination of Zingiber officinale root extract and cannabidiol exhibits potent antiinflammatory effects and ameliorates clinical symptoms of atopic dermatitis
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
VL  - 89
PY  - 2023
IS  - 14
SP  - 1382
EP  - 1382
PG  - 1
SN  - 0032-0943
DO  - 10.1055/s-0043-1774140
UR  - https://m2.mtmt.hu/api/publication/34617346
ID  - 34617346
LA  - English
DB  - MTMT
ER  -