TY - JOUR AU - Appel, Kurt AU - Rose, Thorsten AU - Zimmermann, Christian AU - Günnewich, Nils TI - In Vitro Anti-inflammatory Effects of Larch Turpentine, Turpentine Oil, Eucalyptus Oil, and Their Mixture as Contained in a Marketed Ointment JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 90 PY - 2024 SN - 0032-0943 DO - 10.1055/a-2388-7527 UR - https://m2.mtmt.hu/api/publication/35260990 ID - 35260990 AB - An ointment containing larch turpentine, turpentine oil, and eucalyptus oil has been used for almost a century for the symptomatic treatment of mild, localized, purulent inflammations of the skin. Its clinical efficacy in the treatment of skin infections has been shown in clinical trials, but the mode of action of the active ingredients on inflammation is not known. We studied the anti-inflammatory properties of the active ingredients of the ointment and their mixture in a human monocyte cell model, in which the cells were stimulated with lipopolysaccharide and incubated with the test substances. The cytotoxic threshold of each test substance and the mixture was identified using the alamarBlue assay, and their anti-inflammatory activity was assessed by measuring the release of interleukins IL-1β, IL-6, IL-8, monocyte chemoattractant protein-1, prostaglandin E2, and TNF-α. Cell toxicity was observed at a mixture concentration of 10 µg/mL. All immunological assays were carried out at nontoxic concentrations. Larch turpentine decreased IL-1β, monocyte chemoattractant protein-1, and prostaglandin E2 release at a concentration of 3.9 µg/mL and TNF-α at concentrations > 1.95 µg/mL, whereas eucalyptus oil and turpentine oil had no relevant inhibitory effects. The mixture dose-dependently inhibited IL-1β, IL-6, monocyte chemoattractant protein-1, prostaglandin E2, and TNF-α release at concentrations > 1 µg/mL. IL-8 release was only marginally affected. The anti-inflammatory activity of the herbal ingredients and their mixture was confirmed in this model. This effect seems to be mediated mainly by larch turpentine, with turpentine oil and eucalyptus oil exerting an additive or possibly synergistic function. LA - English DB - MTMT ER - TY - JOUR AU - Matin, Maima AU - Bin, Matin Farhan AU - Ksepka, Natalia AU - Wysocki, Kamil AU - Mickael, Michel-Edwar AU - Wieczorek, Marek AU - Horbanczuk, Jaroslaw Olav AU - Jozwik, Artur AU - Atanasov, Atanas G. TI - The Clinical Research on Ginger ( Zingiber officinale ): Insights from ClinicalTrials.gov analysis JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED PY - 2024 PG - 10 SN - 0032-0943 DO - 10.1055/a-2357-7064 UR - https://m2.mtmt.hu/api/publication/35202707 ID - 35202707 AB - Ginger ( Zingiber officinale ) has a rich history of traditional medicinal use and has attracted a global interest in its health benefits. This study aims to provide insights into the clinical research landscape on ginger, focusing on its pharmacological effects and studied health-related outcomes. The study design involves systematic analysis of data from clinical trials available on ClinicalTrials.gov and discussion of findings in the context of the existing scientific knowledge. A comprehensive analysis of clinical trials registered on ClinicalTrials.gov related to ginger was first conducted, and the scientific background related to specific ginger clinical research avenues was further evaluated through PubMed searches. A variety of trial designs were identified, including treatment, prevention, and supportive care objectives. A total of 188 studies were identified on ClinicalTrials.gov, of which 89 met the inclusion criteria. Among the 89 trials, treatment objectives were predominant (47.2%), and dietary supplements (40.4%) and drugs (27%) were the most prevalent intervention types. These trials covered various health outcomes, such as antiemetic activity, analgesic function, effects on health-related quality of life, blood pressure variation, energy expenditure, and reduction in xerostomia. This study analysis provides a comprehensive overview of the clinical trials landscape on ginger, focusing on its broad spectrum of potential health benefits. While individual trials show promising results, a significant gap in the available data with a low reporting rate of final results is identified, underscoring the need for further research to establish conclusive evidence of ginger's therapeutic potentials. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Barbara AU - Horváth, Attila AU - Jójártné Laczkovich, Orsolya AU - Biró, Dalma AU - Matuz, Mária AU - Csupor, Dezső TI - Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 90 PY - 2024 IS - 9 SP - 736 EP - 740 PG - 5 SN - 0032-0943 DO - 10.1055/a-2283-8147 UR - https://m2.mtmt.hu/api/publication/34728728 ID - 34728728 AB - Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, plastic container). 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease of 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy. LA - English DB - MTMT ER - TY - JOUR AU - Eichenauer, E. AU - Saukel, J. AU - Glasl, S. TI - VOLKSMED Database: A Source for Forgotten Wound Healing Plants in Austrian Folk Medicine # JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 90 PY - 2024 IS - 7-8 SP - 498 EP - 511 PG - 14 SN - 0032-0943 DO - 10.1055/a-2225-7545 UR - https://m2.mtmt.hu/api/publication/35088101 ID - 35088101 N1 - Division of Pharmacognosy, Department of Pharmaceutical Sciences, University of Vienna, Austria Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Austria Export Date: 8 July 2024 CODEN: PLMEA Correspondence Address: Glasl, S.; Division of Pharmacognosy, Josef-Holaubek-Platz 2, Austria; email: sabine.glasl@univie.ac.at LA - English DB - MTMT ER - TY - JOUR AU - Dalavaye, N. AU - Nicholas, M. AU - Pillai, M. AU - Erridge, S. AU - Sodergen, M.H. TI - The Clinical Translation of α-humulene - A Scoping Review JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 90 PY - 2024 IS - 09 SP - 664 EP - 674 PG - 11 SN - 0032-0943 DO - 10.1055/a-2307-8183 UR - https://m2.mtmt.hu/api/publication/34859278 ID - 34859278 LA - English DB - MTMT ER - TY - JOUR AU - Pandey, Pankaj AU - Idrisi, Mantasha AU - Ali, Zulfiqar AU - Husain, Islam AU - Neal, William M. AU - Khan, Shabana I AU - Ferreira, Daneel AU - Chittiboyina, Amar G. AU - Khan, Ikhlas A. TI - iso -Guttiferone J and Structure Revision of Guttiferone J from Garcinia gummi-gutta : A Combined Experimental and Integrated QM/NMR Approach JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 90 PY - 2024 IS - 07/08 SP - 631 EP - 640 PG - 10 SN - 0032-0943 DO - 10.1055/a-2232-4755 UR - https://m2.mtmt.hu/api/publication/35341217 ID - 35341217 LA - English DB - MTMT ER - TY - JOUR AU - Bahiraii, Sheyda AU - Braunboeck-Mueller, Barbara AU - Heiss, Elke H. TI - Increased Glycolytic Activity Is Part of Impeded M1(LPS) Macrophage Polarization in the Presence of Urolithin A JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 90 PY - 2024 IS - 07/08 SP - 546 EP - 553 PG - 8 SN - 0032-0943 DO - 10.1055/a-2240-7462 UR - https://m2.mtmt.hu/api/publication/35333438 ID - 35333438 LA - English DB - MTMT ER - TY - JOUR AU - Zwerger, Michael AU - Boeck, Lynda AU - Manzl, Julia AU - Schwaiger, Stefan AU - Ganzera, Markus TI - Novel Approaches for the Analysis and Isolation of Benzylisoquinoline Alkaloids in Chelidonium majus JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 90 PY - 2024 IS - 07/08 SP - 523 EP - 533 PG - 11 SN - 0032-0943 DO - 10.1055/a-2204-5686 UR - https://m2.mtmt.hu/api/publication/35284595 ID - 35284595 LA - English DB - MTMT ER - TY - JOUR AU - Prosche, Sinah AU - Stappen, Iris TI - Flower Power: An Overview on Chemistry and Biological Impact of Selected Essential Oils from Blossoms JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 90 PY - 2024 IS - 07/08 SP - 595 EP - 626 PG - 32 SN - 0032-0943 DO - 10.1055/a-2215-2791 UR - https://m2.mtmt.hu/api/publication/35055386 ID - 35055386 N1 - Export Date: 14 September 2024 CODEN: PLMEA AB - Natural raw materials such as essential oils have received more and more attention in recent decades, whether in the food industry, as flavorings and preservatives, or as insecticides and insect repellents. They are, furthermore, very popular as fragrances in perfumes, cosmetics, and household products. In addition, aromatherapy is widely used to complement conventional medicine. This review summarizes investigations on the chemical composition and the most important biological impacts of essential oils and volatile compounds extracted from selected aromatic blossoms, including Lavandula angustifolia, Matricaria recutita, Rosa x damascena, Jasminum grandiflorum, Citrus x aurantium, Cananga odorata, and Michelia alba. The literature was collected from PubMed, Google Scholar, and Science Direct. Blossom essential oils discussed in this work are used in a wide variety of clinical issues. The application is consistently described as safe in studies and meta-analyses, although there are notes that using essential oils can also have side effects, especially dermatologically. However, it can be considered as confirmed that essential oils have positive influences on humans and can improve quality of life in patients with psychiatric disorders, critically ill patients, and patients in other exceptional situations. Although the positive effect of essential oils from blossoms has repeatedly been reported, evidence-based clinical investigations are still underrepresented, and the need for research is demanded. LA - English DB - MTMT ER - TY - JOUR AU - Son, Ninh The AU - Gianibbi, Beatrice AU - Panti, Alice AU - Spiga, Ottavia AU - Bastos, Jairo Kenupp AU - Fusi, Fabio TI - Vasorelaxant Activity of (2S)-Sakuranetin and Other Flavonoids Isolated from the Green Propolis of the Caatinga Mimosa tenuiflora JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED VL - 90 PY - 2024 IS - 06 SP - 454 EP - 468 PG - 15 SN - 0032-0943 DO - 10.1055/a-2294-7042 UR - https://m2.mtmt.hu/api/publication/34923857 ID - 34923857 LA - English DB - MTMT ER -