@article{MTMT:34728728,
	title = {Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials},
	url = {https://m2.mtmt.hu/api/publication/34728728},
	author = {Tóth, Barbara and Horváth, Attila and Jójártné Laczkovich, Orsolya and Biró, Dalma and Matuz, Mária and Csupor, Dezső},
	doi = {10.1055/a-2283-8147},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	unique-id = {34728728},
	issn = {0032-0943},
	abstract = {Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, plastic container). 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease of 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy.},
	year = {2024},
	eissn = {1439-0221},
	orcid-numbers = {Tóth, Barbara/0000-0002-6086-8819; Matuz, Mária/0000-0002-7877-2399; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:34170092,
	title = {Immulina as an Immunostimulatory Supplement: Formulation and Pharmacological Studies},
	url = {https://m2.mtmt.hu/api/publication/34170092},
	author = {Li, Y. and Ji, N. and Wang, M. and Pugh, N.D. and Khan, I.A. and Tan, C.},
	doi = {10.1055/a-2156-4653},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	unique-id = {34170092},
	issn = {0032-0943},
	abstract = {Immulina is a commercially available extract of Arthrospira platensis enriched with bacterial lipoproteins that acts as a potent Toll-like receptor 2 agonist. However, the immunostimulatory effect of Immulina is not well understood in vivo. Here, to devise an Immulina formulation suitable for in vivo oral gavage dosing, Immulina nanosuspension was prepared and freeze-dried to yield lyophilized nano-Immulina, which had an average particle size of around 300 nm and fully retained the bioactivity as a Toll-like receptor 2 agonist. Compared to the regular Immulina powder, lyophilized nano-Immulina notably accelerated the dissolution in aqueous media. Immulina nanosuspension was found to stimulate the production of proinflammatory cytokines in murine bone marrow-derived dendritic cells and macrophages. The immune response to Immulina was investigated in healthy mice by longitudinally monitoring the phagocytic activity of circulating neutrophils as a surrogate marker. Following daily oral ingestion of Immulina nanosuspension (10 mg/mouse/day), the phagocytic activity of circulating neutrophils was significantly elevated, suggesting an important mechanism for Immulina to enhance innate immunity. © 2023 Georg Thieme Verlag. All rights reserved.},
	keywords = {PHAGOCYTOSIS; neutrophil; DISSOLUTION; TLR2; Arthrospira platensis; Immulina; Phormidiaceae},
	year = {2023},
	eissn = {1439-0221}
}

@article{MTMT:34149122,
	title = {Impact of Phylogenetically Diverse Bacterial Endophytes of Bergenia pacumbis on Bergenin Production in the Plant Cell Suspension Cultures},
	url = {https://m2.mtmt.hu/api/publication/34149122},
	author = {Wawrosch, C. and Oberhofer, M. and Steinbrecher, S. and Zotchev, S.B.},
	doi = {10.1055/a-2162-4018},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	unique-id = {34149122},
	issn = {0032-0943},
	abstract = {Plant in vitro cultures are potential sources for secondary metabolites. However, low productivity is often a major drawback for industrial application. Elicitation is an important strategy to improve product formation in vitro. In this context, endophytes are of special interest as biotic elicitors due to their possible interaction with the metabolism of the host plant. A total of 128 bacterial endophytes were isolated from the medicinal plant Bergenia pacumbis and taxonomically classified using 16S rRNA gene sequencing. Five strains belonging to different genera were grown in lysogeny broth and tryptic soy broth medium and cells as well as spent media were used as elicitors in cell suspension cultures of B. pacumbis. Production of the main bioactive compound bergenin was enhanced 3-fold (964 μg/g) after treatment with cells of Moraxella sp. or spent tryptic soy broth medium of Micrococcus sp. These results indicate that elicitation of plant cell suspension cultures with endophytic bacteria is a promising strategy for enhancing the production of desired plant metabolites. © 2023 Georg Thieme Verlag. All rights reserved.},
	keywords = {Elicitation; Saxifragaceae; Endophytes; cell suspension culture; Bergenin; Bergenia pacumbis},
	year = {2023},
	eissn = {1439-0221}
}

@article{MTMT:33675095,
	title = {Development and Evaluation of Khellin-loaded Microemulgel for Dermatological Applications},
	url = {https://m2.mtmt.hu/api/publication/33675095},
	author = {Grifoni, L. and Vanti, G. and Vannucchi, M.G. and Bergonzi, M.C. and Bilia, A.R.},
	doi = {10.1055/a-1789-3112},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {89},
	unique-id = {33675095},
	issn = {0032-0943},
	year = {2023},
	eissn = {1439-0221},
	pages = {848-855}
}

@article{MTMT:33041483,
	title = {Binary Synergistic Combinations of Lavender and Fennel Essential Oils with Amoxicillin},
	url = {https://m2.mtmt.hu/api/publication/33041483},
	author = {Karadağ, Ayşe Esra and Çaşkurlu, Ayşegül and Demirci, Betül and Demirci, Fatih},
	doi = {10.1055/a-1891-1119},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {89},
	unique-id = {33041483},
	issn = {0032-0943},
	abstract = {Microbial resistance is an important problem in modern healthcare systems. In addition to drug resistance, the side effects of current antibiotic applications are also known issues. In this present study, binary combinations of amoxicillin with European Pharmacopoeia quality lavender (Lavandula angustifolia) and fennel (Foeniculum vulgare) essential oils were evaluated against human pathogenic microbial strains. The checkerboard method was used to quantify the efficacy of essential oils in combination with amoxicillin. As an initial result, remarkable in vitro antimicrobial activity was observed at relatively low amoxicillin concentrations using different oil combinations against Staphylococcus aureus ATCC 6538, Enterococcus faecalis ATCC 29212, Bacillus cereus ATCC 14579, and Escherichia coli NRRL B-3008, Salmonella typhi (Clinical isolate), respectively. Fractional inhibitory concentrations (FIC) were calculated and interpreted in terms of addition, synergy, antagonism, or indifferent, respectively. A synergistic interaction was shown for E. faecalis and E. coli with the combination F. vulgare essential oil and amoxicillin (FICI= 8.05 x 10-4). Both essential oils together, and in combination with amoxicillin showed a synergistic effect as well.},
	year = {2023},
	eissn = {1439-0221},
	pages = {800-807}
}

@article{MTMT:34313835,
	title = {Structural Characterization and Anticomplement Activity of an Acidic Heteropolysaccharide from Lysimachia christinae Hance},
	url = {https://m2.mtmt.hu/api/publication/34313835},
	author = {Hong, Zhou and Zhou, Li-Shuang and Zhao, Zhi-Zhi and Yuan, Guo-Qi and Wang, Xiao-Jiang and Lu, Yan and Chen, Dao-Feng},
	doi = {10.1055/a-2148-7163},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {89},
	unique-id = {34313835},
	issn = {0032-0943},
	abstract = {A novel acidic heteropolysaccharide (LCP-90-1) was isolated and purified from a traditional "heat-clearing" Chinese medicine, Lysimachia christinae Hance. LCP-90-1 ( Mw , 20.65 kDa) was composed of Man, Rha, GlcA, Glc, Gal, and Ara, with relative molar ratios of 1.00: 3.00: 11.62: 1.31: 1.64: 5.24. The backbone consisted of 1,4- alpha -D-Glc p A, 1,4- alpha -D-Glc p , 1,4- beta -L-Rhap , and 1,3,5- alpha -L-Ara f , with three branches of beta -D-Gal p -(1 -> 4)- beta -L-Rha p -(1 ->, alpha -L-Ara f -(1 -> and alpha -D-Man p -(1 -> attached to the C-5 position of 1,3,5- alpha -L-Ara f . LCP-90-1 exhibited potent anticomplement activity (CH 50 : 135.01 +/- 0.68 mu g/mL) in vitro , which was significantly enhanced with increased glucuronic acid (GlcA) content in its degradation production (LCP-90-1-A, CH50 : 28.26 +/- 0.39 mu g/mL). However, both LCP-90-1 and LCP90-1-A were inactivated after reduction or complete acid hydrolysis. These observations indicated the important role of GlcA in LCP-90-1 and associated derivatives with respect to anticomplement activity. Similarly, compared with LCP-90-1, the antioxidant activity of LCP-90-1-A was also enhanced. Thus, polysaccharides with a high content of GlcA might be important and effective substances of L. christinae .},
	keywords = {STRUCTURAL CHARACTERIZATION; polysaccharide; Primulaceae; Anticomplement; Lysimachia christinae},
	year = {2023},
	eissn = {1439-0221},
	pages = {1457-1467}
}

@article{MTMT:34741172,
	title = {Analysis of pollen in "handmade" honey samples from the central microregion of Romania by scanning electron microscopy},
	url = {https://m2.mtmt.hu/api/publication/34741172},
	author = {Zold, Eszter Laczko and Koreh, Beata and Jakab-Farkas, Laszlo and Domokos, Erzsébet},
	doi = {10.1055/s-0043-1774199},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {89},
	unique-id = {34741172},
	issn = {0032-0943},
	year = {2023},
	eissn = {1439-0221},
	pages = {1401-1401},
	orcid-numbers = {Domokos, Erzsébet/0000-0002-0736-5243}
}

@article{MTMT:34741171,
	title = {Volatile compounds from Heracleum sphondylium L. Leaves and Fruits as identified by GC/MS},
	url = {https://m2.mtmt.hu/api/publication/34741171},
	author = {Zold, Eszter Laczko and Stefanescu, Ruxandra and Vancea, Szende and Domokos, Erzsébet},
	doi = {10.1055/s-0043-1774058},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {89},
	unique-id = {34741171},
	issn = {0032-0943},
	year = {2023},
	eissn = {1439-0221},
	pages = {1357-1357},
	orcid-numbers = {Stefanescu, Ruxandra/0000-0002-3346-3867; Domokos, Erzsébet/0000-0002-0736-5243}
}

@article{MTMT:34741167,
	title = {Secretory tissues from Heracleum sphondylium L. fruits in different maturity stages},
	url = {https://m2.mtmt.hu/api/publication/34741167},
	author = {Zold, Eszter Laczko and Darko, Bela and Domokos, Erzsébet},
	doi = {10.1055/s-0043-1774040},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {89},
	unique-id = {34741167},
	issn = {0032-0943},
	year = {2023},
	eissn = {1439-0221},
	pages = {1352-1352},
	orcid-numbers = {Domokos, Erzsébet/0000-0002-0736-5243}
}

@article{MTMT:34617346,
	title = {A combination of Zingiber officinale root extract and cannabidiol exhibits potent antiinflammatory effects and ameliorates clinical symptoms of atopic dermatitis},
	url = {https://m2.mtmt.hu/api/publication/34617346},
	author = {Kragl, Martin and Neubauer, Christine and Moritz, Kathrin and Ziegler, Ramona and Maehler, Nicole and Soeberdt, Michael and Bonyadirad, Ehsan and Braun, Theodor and Filipek, Przemyslaw and Jakschitz, Thomas and Koeberle, Andreas and Bonn, Gunther and Abels, Christoph},
	doi = {10.1055/s-0043-1774140},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {89},
	unique-id = {34617346},
	issn = {0032-0943},
	year = {2023},
	eissn = {1439-0221},
	pages = {1382-1382}
}