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class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Savvidou Antri ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sofou Kalliopi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Thunstrom Sofia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ygberg Sofia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Eklund Erik A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Naess Karin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kollberg Gittan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Darin Niklas </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37164127" target="_blank">A Nationwide Study of Pyruvate Dehydrogenase Complex Deficiency in Sweden: Epidemiology, Genotype-Phenotype Correlations, and Survival</a></div> <div> <span class="journal-title">NEUROLOGY</span> <span 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class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Queen Silvia Children's Hospital Research Foundation; Linnea and Josef Carlssons Research Foundation; Swedish state [ALFGBG-1005213, ALFGBG-70150] Funding text: The study was supported by the Queen Silvia Children's Hospital Research Foundation (A.S.), Linnea and Josef Carlssons Research Foundation (N.D., A.S.), and the Swedish state under the agreem...</pre> </div></div> JournalArticle 37218982 VALIDATED true 0 false 2026-05-19T12:12:04.173+0000 2026-05-19T12:10:31.329+0000 2026-05-19T12:10:30.127+0000 true 521 Szuper Admin /api/admin/521 Admin true 2026-05-19T12:10:30.005+0000 2026-05-19T12:10:30.005+0000 2026-05-19T12:10:30.413+0000 true 521 Szuper Admin /api/admin/521 Admin true false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle 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(40) </div> <div><a target="_blank" href="/api/publication/37292880?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37292880" target="_blank">Effect of Cognitive Reserve on Age at Symptom Onset and Cognitive Decline in Individuals With Dominantly Inherited Alzheimer Disease</a></div> <div> <span class="journal-title">NEUROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-3878">0028-3878</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1526-632X">1526-632X</a>)</span>: <span class="journal-volume">106</span> <span class="journal-issue">8</span> <span class="page"> Paper e214804. 12 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1212/WNL.0000000000214804" target="_blank" href="https://doi.org/10.1212/WNL.0000000000214804"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001755688700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001755688700001"> WoS </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;37292880&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 37292880</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.12. 20:20 Pécsi Éva (MTMT Közp 2,3, admin) </div> </div></div> JournalArticle 37029359 VALIDATED true 0 false 2026-05-24T05:19:57.767+0000 2026-04-20T08:12:27.904+0000 2026-03-25T08:23:51.556+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-05-24T05:18:46.619+0000 2026-03-25T08:49:55.514+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Siriratnam, Pakeeran Impact of Age at Onset on Relapse and Disability in AQP4-IgG Neuromyelitis Optica Spectrum Disorder true true /api/journal/3355 REVIEWED true false 3355 false 3355 true 0028-3878 1526-632X Journal FOREIGN 106 7 e214707 e214707 12 2026 Background and Objectives Previous studies have reported inconsistent findings regarding the impact of age at onset on relapse risk in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-IgG NMOSD), although older disease onset has been linked to more rapid disability accrual. This is in contrast to multiple sclerosis, where advancing age and older onset are associated with reduced relapse activity, allowing for treatment de-escalation or discontinuation in some older patients. The aim of this study was to clarify the influence of age at onset on relapse risk as well as disability accrual in a large, international cohort of patients with NMOSD. Methods We conducted a retrospective, multicenter cohort study using the MSBase data registry to evaluate annualized relapse rates (ARRs), time to first relapse, and time to Expanded Disability Status Scale (EDSS) scores of 4 and 6. For inclusion, a diagnosis of AQP4-IgG NMOSD according to the latest iteration of the criteria and availability of the minimum data set were required. Patients were stratified as pediatric onset (<18 years of age), early onset (18-55 years inclusive) or late onset (>55 years of age). Analyses included patients on high-efficacy therapy (HET), those on low-efficacy therapy (LET), and an incident cohort with the first clinical visit within 12 months from disease onset. Predictors of first relapse and EDSS 4/6 thresholds were analyzed using Cox proportional models. Results Data from 539 patients (42 pediatric, 421 with early onset, 76 with late onset; 85.2% female) with a median age at onset of 35 years (Q1 25.10, Q3 47.60) and a disease duration of 7.42 years (Q1 3.23, Q3 13.10) were analyzed. ARR and time to first relapse were not influenced by age at disease onset. Patients on HET had fewer relapses than those on LET (p < 0.001). Older age was linked to faster disability accumulation. In addition, higher baseline EDSS scores and delayed treatment were independent predictors of future disability. Discussion Our study demonstrates that while age at onset does not affect relapse risk, older patients experience more rapid disability accrual. These findings underscore the importance of early initiation of effective preventive immunotherapy in all age groups. 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Magdolna (<span class="authorship-author-name">Simó Magdolna</span> <span class="authorAux-mtmt"> Neuroimmonológia, Izombetegségek, Elektrofiziol...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; et al. (34) </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">MSBase Investigators</span> </div> <div><a target="_blank" href="/api/publication/37029359?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37029359" target="_blank">Impact of Age at Onset on Relapse and Disability in AQP4-IgG Neuromyelitis Optica Spectrum Disorder</a></div> <div> <span class="journal-title">NEUROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-3878">0028-3878</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1526-632X">1526-632X</a>)</span>: <span class="journal-volume">106</span> <span class="journal-issue">7</span> <span class="page"> Paper e214707. 12 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1212/WNL.0000000000214707" target="_blank" href="https://doi.org/10.1212/WNL.0000000000214707"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001707898300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001707898300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105032342070" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105032342070"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41785437" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41785437&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology (clinical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;37029359&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 37029359</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.04.20. 10:12 Tóth Andrea (SZTE admin5 ÁOK Neurológiai Klinika) </div> </div></div>