TY - JOUR AU - Losso, L. AU - Carollo, M. AU - Ricci, G. TI - Gap junction modulators: Prospects in bupropion cardiotoxicity JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 185 PY - 2024 SN - 0306-9877 DO - 10.1016/j.mehy.2024.111296 UR - https://m2.mtmt.hu/api/publication/34720715 ID - 34720715 N1 - USD Poison Control Center, Azienda Ospedaliera Universitaria Integrata, Verona, Italy Department of Diagnostics and Public Health, University of Verona, Verona, Italy Export Date: 5 March 2024 CODEN: MEHYD Correspondence Address: Carollo, M.; Department of Diagnostics and Public Health, Italy; email: massimo.carollo@univr.it Chemicals/CAS: amfebutamone, 31677-93-7, 34911-55-2, 144445-76-1; danegaptide, 943134-39-2 AB - Bupropion, a multifaceted antidepressant, is associated with serious cardiotoxicity when misused. Recently, there has been a noticeable increase in cases of intentional poisoning and current therapeutic interventions for bupropion overdose remain insufficient. The cardiotoxic effects of the drug are primarily linked to its influence on cardiac gap junctions. Small-molecule drugs enhancing gap junction conductance, such as rotigaptide and danegaptide, present potential as antidotal agents. Testing these molecules under conditions of bupropion overdose could address the urgent need for innovative approaches to mitigate bupropion-induced cardiotoxicity. © 2024 The Author(s) LA - English DB - MTMT ER - TY - JOUR AU - Pourhajibagher, M. AU - Bahrami, R. AU - Bahador, A. TI - Revolution of artificial intelligence in antimicrobial, anti-biofilm, and anti-inflammatory techniques: Smart photo-sonodynamic appliance in the internet of dental things (IoDT) JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 184 PY - 2024 SN - 0306-9877 DO - 10.1016/j.mehy.2024.111270 UR - https://m2.mtmt.hu/api/publication/34719955 ID - 34719955 N1 - Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran Dental Sciences Research Center, Department of Orthodontics, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Fellowship in Clinical Laboratory Sciences, BioHealth Lab, Tehran, Iran Export Date: 4 March 2024 CODEN: MEHYD Correspondence Address: Bahrami, R.; Dental Sciences Research Center, Iran; email: bahramirashin@yahoo.com AB - Antimicrobial photo-sonodynamic therapy (aPSDT) is a promising treatment for microbial infections, but it faces challenges such as bacterial resistance, limited anti-inflammatory effects, and a doctor-centered approach. We hypothesize that the integration of artificial intelligence (AI), Internet of Dental Things (IoDT), and aPSDT to enhance the efficiency and effectiveness of aPSDT by focusing on four crucial aspects—patients' usage, antimicrobial efficacy, biofilm prevention, and inflammation reduction. By leveraging IoDT, patients can utilize specialized dental devices outside of the traditional clinic setting, enabling remote access to treatment information, monitoring disinfection and progress, receiving guidance, and making necessary adjustments remotely. This integration enhances convenience and efficiency for both patients and dental professionals. Additionally, AI plays a crucial role in combating antimicrobial resistance and improving the efficacy of aPSDT. Through data analysis, AI can predict the development of resistance, simulate microbial evolution, monitor treatment responses, recommend combination therapies, and personalize treatment plans. Furthermore, AI has the potential to augment the effectiveness of aPSDT in treating inflammation by employing image analysis, personalized treatment planning, real-time monitoring, and therapeutic discovery. © 2024 Elsevier Ltd LA - English DB - MTMT ER - TY - JOUR AU - Lakshmanan, M. Divya AU - Ali, H. Shabeer TI - Remdesivir may hinder the function of Recombination Activating Gene-1 (RAG1) JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 182 PY - 2024 PG - 9 SN - 0306-9877 DO - 10.1016/j.mehy.2023.111228 UR - https://m2.mtmt.hu/api/publication/34666660 ID - 34666660 LA - English DB - MTMT ER - TY - JOUR AU - Poullis, Michael TI - Central vs peripheral vascular factors determining risk of aortic dissection JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 182 PY - 2024 PG - 8 SN - 0306-9877 DO - 10.1016/j.mehy.2023.111235 UR - https://m2.mtmt.hu/api/publication/34659814 ID - 34659814 LA - English DB - MTMT ER - TY - JOUR AU - Targonski, Ryszard AU - Kowacz, Magdalena AU - Oraczewski, Rafal AU - Thoene, Michael AU - Targonski, Radoslaw TI - The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 182 PY - 2024 PG - 7 SN - 0306-9877 DO - 10.1016/j.mehy.2023.111234 UR - https://m2.mtmt.hu/api/publication/34636156 ID - 34636156 LA - English DB - MTMT ER - TY - JOUR AU - Noulsri, Egarit AU - Lerdwana, Surada TI - MALAT1: A novel hypothesis on the pathology of vascular injury in patients with β-thalassemia JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 182 PY - 2024 PG - 4 SN - 0306-9877 DO - 10.1016/j.mehy.2023.111232 UR - https://m2.mtmt.hu/api/publication/34628095 ID - 34628095 LA - English DB - MTMT ER - TY - JOUR AU - Wang, Jiaqi AU - Chang, Raymond Chuen Chung AU - Chu, John Man Tak AU - Wong, Gordon Tin Chun TI - Is adiponectin deficiency a critical factor for sevoflurane induced neurocognitive dysfunction? JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 182 PY - 2024 PG - 4 SN - 0306-9877 DO - 10.1016/j.mehy.2023.111241 UR - https://m2.mtmt.hu/api/publication/34622548 ID - 34622548 LA - English DB - MTMT ER - TY - JOUR AU - Boros, László G. AU - Seneff, Stephanie AU - Lech, James C. AU - Túri, Marianna AU - Répás, Zoltán TI - Summiting Mount Everest in deuterium depleting nutritional ketosis without supplemental oxygen JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 184 PY - 2024 PG - 5 SN - 0306-9877 DO - 10.1016/j.mehy.2024.111290 UR - https://m2.mtmt.hu/api/publication/34610917 ID - 34610917 AB - During climbing seasons in the Himalaya only a few sportsmen attempt an ascent to and descent from the 8848 m top of the Earth without supplemental oxygen. This short report describes such successful summiting of the Mount Everest that rested with the nutritional, metabolic and exercise ketosis state, i.e., the burning of long chain saturated fat as the source of cellular energy after six failed attempts by the same athlete using carbohydratebased nutrition. We herein describe the advantage of ketosis from the medical biochemistry angle by characterizing peroxisomal and mitochondrial cross talk as deuterium (heavy hydrogen) depleting principles in natural ketosis. We emphasize the importance of proton (hydrogen) and oxygen recycling via fatty acid deriving hydrogen peroxide produced in peroxisomes, followed by its conversion to metabolic water and O2 by catalase in mitochondria. Metabolic adaptation to natural ketosis maintains reduced NAD+ and ATP pools even in severely oxygen deprived environments. We hypothesize that severely decreased atmospheric oxygen pressure above 7000 m compromises alveolar gas exchange so much that biological oxidation becomes dependent on natural hydrocarbon (fat) based nutritional and consequent metabolic adaptation to natural ketosis. Such substrate level coupling of peroxisomal and mitochondrial metabolism via fatty acid breakdown aids oxygen recycling in muscles and tissues as a lifesaving option for the extreme climber. LA - English DB - MTMT ER - TY - JOUR AU - Cheng, T. AU - Chen, Z. AU - Qin, Y. AU - Zhu, X. AU - Chen, H. AU - Xu, Z. AU - Ma, X. TI - Alleviating morphine-induced itching while sustaining its analgesic efficacy: Esketamine as a potential co-administrating choice JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 182 PY - 2024 SN - 0306-9877 DO - 10.1016/j.mehy.2023.111211 UR - https://m2.mtmt.hu/api/publication/34568698 ID - 34568698 N1 - Export Date: 9 February 2024 CODEN: MEHYD Correspondence Address: Xu, Z.; Department of Anesthesiology, China; email: xuzling_ntmed@163.com Chemicals/CAS: esketamine, 33643-46-8, 33643-47-9; morphine, 52-26-6, 57-27-2 Funding details: BSH202221, Tdb2119 Funding details: QN2022001 Funding details: National Natural Science Foundation of China, NSFC, 82201366 Funding text 1: This work was supported by grant from the Young Scholarship Program of the National Natural Science Foundation of China to Xiaqing Ma (82201366), the Young Scholarship Program of Nantong Health Commission (QN2022001), and the Natural Science Foundation of Affiliated Hospital of Nantong University to Xiaqing Ma (Tdb2119 and BSH202221). AB - Morphine is one of the most commonly used and effective analgesic drugs in clinical practice. Morphine injected directly into the epidural and subarachnoid space acts directly on the central nervous system compared to oral or intravenous administration. This route of morphine delivery requires only a small dose to achieve satisfactory analgesia and greatly reduces the risk of adverse effects. However, morphine-induced itching significantly limits the clinical use of morphine and the maximization of its analgesic effects. Drugs commonly used worldwide to treat morphine-induced pruritus have different degrees of limitations. N-Methyl-D-aspartate (NMDA) receptors are involved in the mechanisms associated with morphine-induced itching. Theoretically, esketamine, an NMDA antagonist, which is commonly used in clinical practice to exert analgesic and sedative effects and contributes to circulatory stability, has the potential to effectively relieve morphine-induced itching without compromising its analgesic effects. In this paper, we discuss the possibility of co-administration of esketamine in cases of morphine-induced pruritus based on the current clinical situation and relevant mechanisms, with the intention of developing novel therapeutic options for morphine-induced pruritus. © 2023 Elsevier Ltd LA - English DB - MTMT ER - TY - JOUR AU - Bateman, G.A. AU - Bateman, A.R. TI - Chronic fatigue syndrome and multiple sclerosis have reduced craniospinal compliance and dilated pressurized bridging cortical veins JF - MEDICAL HYPOTHESES J2 - MED HYPOTHESES VL - 182 PY - 2024 SN - 0306-9877 DO - 10.1016/j.mehy.2023.111243 UR - https://m2.mtmt.hu/api/publication/34525861 ID - 34525861 N1 - Department of Medical Imaging, John Hunter Hospital, Newcastle, NSW, Australia Newcastle University, Faculty of Health, Callaghan Campus, Newcastle, NSW, Australia School of Mechanical Engineering, University of New South Wales, Sydney, NSW, Australia Export Date: 23 January 2024 CODEN: MEHYD Correspondence Address: Bateman, G.A.; Department of Medical Imaging, Locked Bag 1, Newcastle Region Mail Center, 2310, Australia; email: grant.bateman@health.nsw.gov.au AB - Chronic fatigue syndrome (CFS) and multiple sclerosis (MS) share similarities regarding their epidemiology, symptomatology and craniospinal physiology. Indeed, the cardinal feature of CFS, fatigue, is also a major factor in the symptomatology of the majority of MS patients. Recently, we have found that there is a significant reduction in the craniospinal compliance in MS which affects both the stiffness of the walls of the spinal canal and the walls of the cerebral venous system. This change in compliance brings about an alteration in the effectiveness of the pulse wave dampening in the craniospinal system. The result is an impedance mismatch between the cortical veins and their draining sinuses, leading to dilatation of these upstream veins. We deduce this dilatation can only be brought about by an increase in the pressure gradient between the vein lumen and the subarachnoid space (i.e. the transmural pressure gradient). We hypothesise that given the similarities between MS and CFS, a similar mechanism underlies the physiology of CFS. We present two case studies to highlight the expected findings in CFS patients if this hypothesis were proven to be correct. © 2023 LA - English DB - MTMT ER -