TY - JOUR AU - Bagg, M.K. AU - Hellewell, S.C. AU - Keeves, J. AU - Antonic-Baker, A. AU - McKimmie, A. AU - Hicks, A.J. AU - Gadowski, A. AU - Newcombe, V.F.J. AU - Barlow, K.M. AU - Balogh, Z.J. AU - Ross, J.P. AU - Law, M. AU - Caeyenberghs, K. AU - Parizel, P.M. AU - Thorne, J. AU - Papini, M. AU - Gill, G. AU - Jefferson, A. AU - Ponsford, J.L. AU - Lannin, N.A. AU - O’Brien, T.J. AU - Cameron, P.A. AU - Jamie, Cooper D. AU - Rushworth, N. AU - Gabbe, B.J. AU - Fitzgerald, M. TI - The Australian Traumatic Brain Injury Initiative: Systematic Review of Predictive Value of Biological Markers for People With Moderate-Severe Traumatic Brain Injury JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM PY - 2024 SN - 0897-7151 DO - 10.1089/neu.2023.0464 UR - https://m2.mtmt.hu/api/publication/34788747 ID - 34788747 N1 - Curtin Health Innovation Research Institute, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia Centre for Pain IMPACT, Neuroscience Research Australia, Sydney, NSW, Australia School of Health Sciences, University of Notre Dame Australia, Fremantle, WA, Australia School of Public Health and Preventive Medicine Department of Neuroscience, Central Clinical School School of Psychological Sciences, Monash University, Melbourne, VIC, Australia Monash-Epworth Rehabilitation Research Centre, Epworth Healthcare, Melbourne, VIC, Australia School of Medicine, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia PACE Section, Department of Medicine, University of Cambridge, Cambridge, United Kingdom Acquired Brain Injury in Children Research Program, Queensland Children’s Hospital, Brisbane, QLD, Australia Centre for Children’s Health Research, University of Queensland, Brisbane, QLD, Australia Department of Traumatology, John Hunter Hospital, University of Newcastle, Newcastle, NSW, Australia Molecular Diagnostic Solutions, Health and Biosecurity, CSIRO, Australia Alzheimer’s Disease Research Center, United States Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States Department of Neuroscience and Radiology, Monash University, Alfred Health, Melbourne, VIC, Australia Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Australia University of Antwerp, Edegem, Belgium Department of Radiology, Royal Perth Hospital, University of Western Australia, Perth, WA, Australia West Australian National Imaging Facility Node, Nedlands, WA, Australia Alfred Health, Melbourne, VIC, Australia National Trauma Research Institute, Melbourne, VIC, Australia Emergency and Trauma Centre, The Alfred Hospital, Melbourne, VIC, Australia Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia Department of Intensive Care and Hyperbaric Medicine, The Alfred, Melbourne, VIC, Australia Brain Injury Australia, Sydney, NSW, Australia Health Data Research UK, Swansea University Medical School, Swansea University, Singleton Park, United Kingdom Export Date: 15 April 2024; Cited By: 1; Correspondence Address: M. Fitzgerald; Curtin University Neuroscience Laboratory, Ralph and Patricia Sarich Neuroscience Research Institute, Nedlands, 8 Verdun Street, Level 3, 6009, Australia; email: lindy.fitzgerald@curtin.edu.au; CODEN: JNEUE LA - English DB - MTMT ER - TY - JOUR AU - Lubbers, V.F. AU - van, den Hoven D.J. AU - van, der Naalt J. AU - Jellema, K. AU - van, den Brand C. AU - Backus, B. TI - Emergency Department Risk Factors for Post-Concussion Syndrome After Mild Traumatic Brain Injury: A Systematic Review JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM PY - 2024 SN - 0897-7151 DO - 10.1089/neu.2023.0302 UR - https://m2.mtmt.hu/api/publication/34786218 ID - 34786218 N1 - Franciscus Gasthuis and Vlietland Hospital, Rotterdam, Netherlands Erasmus University Medical Center, Rotterdam, Netherlands University of Groningen Medical Center, Groningen, Netherlands Haaglanden Medical Center, the Hague, Netherlands Elisabeth Tweesteden Ziekenhuis, Tilburg, Netherlands Export Date: 12 April 2024 CODEN: JNEUE Correspondence Address: Lubbers, V.F.; Erasmus University Medical CenterNetherlands; email: veerle.lubbers95@gmail.com AB - Approximately 16% of patients with mild traumatic brain injury (mTBI) develop a post-concussion syndrome (PCS) with persistent physical, neurological, and behavioral complaints. PCS has a great impact on a patient’s quality of life, often decreases the ability to return to work, and henceforth has a great economic impact. Recent studies suggest that early treatment can greatly improve prognosis and prevent long-term effects in these patients. However, early recognition of patients at high risk of PCS remains difficult. The objective of this systematic review is to assess risk factors associated with the development of PCS, primarily aimed at the group of non-hospitalized patients who were seen with mTBI at the emergency department (ED). We searched PubMed/MEDLINE, Cochrane Library and EMBASE on September 23, 2022, for prospective studies that assessed the risk factors for the development of PCS. Exclusion criteria were: retrospective studies; > 20% computed tomography (CT) abnormalities, <18 years of age, follow-up <4 weeks, severe trauma, and study population <100 patients. The search strategy identified 1628 articles, of which 17 studies met eligibility criteria. Risk factors found in this systematic review are pre-existing psychiatric history, headache at the ED, neurological symptoms at the ED, female sex, CT abnormalities, pre-existent sleeping problems, and neck pain at the ED. This systematic review identified seven risk factors for development of PCS in patients with mTBI. Future research should assess if implementation of these risk factors into a risk stratification tool will assist the emergency physician in the identification of patients at high risk of PCS. © Mary Ann Liebert, Inc. LA - English DB - MTMT ER - TY - JOUR AU - Kennedy, E. AU - Ozmen, M. AU - Bouldin, E.D. AU - Panahi, S. AU - Mobasher, H. AU - Troyanskaya, M. AU - Martindale, S.L. AU - Merritt, V.C. AU - O’Neil, M. AU - Sponheim, S.R. AU - Remigio-Baker, R.A. AU - Presson, A. AU - Swan, A.A. AU - Kent, Werner J. AU - Greene, T.H. AU - Wilde, E.A. AU - Tate, D.F. AU - Walker, W.C. AU - Pugh, M.J. TI - Phenotyping Depression After Mild Traumatic Brain Injury: Evaluating the Impact of Multiple Injury, Gender, and Injury Context JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - in press PY - 2024 SN - 0897-7151 DO - 10.1089/neu.2023.0381 UR - https://m2.mtmt.hu/api/publication/34774211 ID - 34774211 N1 - VA Salt Lake City Health Care System, Informatics, Decision-Enhancement and Analytic Sciences Center, Salt Lake City, UT, United States Division of Epidemiology, University of Utah School of Medicine, Salt Lake City, UT, United States Department of Electrical and Electronics Engineering, Antalya Bilim University, Döxsemealtı, Antalya, Turkey H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, United States Michael E. DeBakey Veterans Affairs Medical Center, Houston, Holcombe Boulevard, Houston, TX, United States Mid-Atlantic Mental Illness Research, Education, Clinical Center, Research and Academic Affairs Service Line, W. G. (Bill) Hefner VA Healthcare System, Salisbury, NC, United States Department of Physiology & Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States VA San Diego Healthcare System, San Diego, CA, United States Department of Psychiatry, University of California San Diego, La JollaCA, United States Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, United States VA Portland Health Care System, Portland, OR, United States Department of Psychiatry, Oregon Health & Science University, Portland, OR, United States Department of Medical Informatics & Clinical Epidemiology, Oregon Health & Science University, Portland, OR, United States Minneapolis VA Health Care System, Minneapolis, MN, United States Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States Traumatic Brain Injury Center of Excellence (TBICoE), Silver Spring, MD, United States Compass Government Solutions, Annapolis, MD, United States Department of Psychology, The University of Texas at San Antonio, San Antonio, TX, United States Uniformed Services University of the Health Sciences, Bethesda, MD, United States Division of Biostatistics, Department of Population Health Sciences, University of Utah, Salt Lake City, UT, United States Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, United States Physical Medicine and Rehabilitation Service, Richmond Veterans Affairs Medical Center, Richmond, VA, United States Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, United States Export Date: 6 April 2024 CODEN: JNEUE Correspondence Address: Kennedy, E.; Division of Epidemiology, 295 Chipeta Way, United States; email: eamonn.kennedy@utah.edu Funding details: W81XWH-13-2-0095, W81XWH1920067 Funding details: U.S. Department of Defense, DOD Funding details: U.S. Department of Veterans Affairs, VA, I01 CX001135, I01 CX001246, I01 CX001820, I01 CX002096, I01 CX002097, I01 HX003155, I01 RX 001135, I01 RX 001880, I01 RX 002076, I01 RX 002170, I01 RX 002171, I01 RX 002172, I01 RX 002173, I01 RX 002174, I01 RX001774, I01 RX003442, I01 RX003443, I01 RX003444 Funding text 1: This work was supported by the Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, through the Psychological Health/Traumatic Brain Injury Research Program Long-Term Impact of Military-Relevant Brain Injury Consortium (LIMBIC) Award/W81XWH-18-PH/TBIRP-LIMBIC under Awards Numbers W81XWH1920067 and W81XWH-13-2-0095, and by the United States Department of Veterans Affairs Awards Numbers I01 CX001820, I01 CX002097, I01 CX002096, I01 HX003155, I01 RX003444, I01 RX003443, I01 RX003442, I01 CX001135, I01 CX001246, I01 RX001774, I01 RX 001135, I01 RX 002076, I01 RX 001880, I01 RX 002172, I01 RX 002173, I01 RX 002171, I01 RX 002174, and I01 RX 002170. The United States Army Medical Research Acquisition Activity, 839 Chandler Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. AB - The chronic mental health consequences of mild traumatic brain injury (TBI) are a leading cause of disability. This is surprising given the expectation of significant recovery after mild TBI, which suggests that other injury-related factors may contribute to long-term adverse outcomes. The objective of this study was to determine how number of prior injuries, gender, and environment/context of injury may contribute to depressive symptoms after mild TBI among deployed United States service members and veterans (SMVs). Data from the Long-term Impact of Military-Relevant Brain Injury Consortium Prospective Longitudinal Study was used to assess TBI injury characteristics and depression scores previously measured on the Patient Health Questionnaire-9 (PHQ-9) among a sample of 1456 deployed SMVs. Clinical diagnosis of mild TBI was defined via a multi-step process centered on a structured face-to-face interview. Logistical and linear regressions stratified by gender and environment of injury were used to model depressive symptoms controlling for sociodemographic and combat deployment covariates. Relative to controls with no history of mild TBI (n = 280), the odds ratios (OR) for moderate/severe depression (PHQ-9 ‡ 10) were higher for SMVs with one mild TBI (n = 358) OR: 1.62 (95% confidence interval [CI] 1.09–2.40, p = 0.016) and two or more mild TBIs (n = 818) OR: 1.84 (95% CI 1.31–2.59, p < 0.001). Risk differences across groups were assessed in stratified linear models, which found that depression symptoms were elevated in those with a history of multiple mild TBIs compared with those who had a single mild TBI (p < 0.001). Combat deployment-related injuries were also associated with higher depression scores than injuries occurring in non-combat or civilian settings (p < 0.001). Increased rates of depression after mild TBI persisted in the absence of post-traumatic stress disorder. Both men and women SMVs separately exhibited significantly increased depressive symptom scores if they had had combat-related mild TBI. These results suggest that contextual information, gender, and prior injury history may influence long-term mental health outcomes among SMVs with mild TBI exposure. © Mary Ann Liebert, Inc. LA - English DB - MTMT ER - TY - JOUR AU - Mikolic, Ana AU - Brasher, Penelope M. A. AU - Brubacher, Jeffrey R. AU - Panenka, William AU - Scheuermeyer, Frank X. AU - Archambault, Patrick AU - Khazei, Afshin AU - Silverberg, Noah D. TI - External Validation of the Post-Concussion Symptoms Rule for Predicting Mild Traumatic Brain Injury Outcome JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM PY - 2024 PG - 8 SN - 0897-7151 DO - 10.1089/neu.2023.0484 UR - https://m2.mtmt.hu/api/publication/34668120 ID - 34668120 LA - English DB - MTMT ER - TY - JOUR AU - Clarke, Gerard Janez Brett AU - Skandsen, Toril AU - Zetterberg, Henrik AU - Follestad, Turid AU - Einarsen, Cathrine Elisabeth AU - Vik, Anne AU - Mollnes, Tom Eirik AU - Pischke, Soren Erik AU - Blennow, Kaj AU - Haberg, Asta Kristine TI - Longitudinal Associations Between Persistent Post-Concussion Symptoms and Blood Biomarkers of Inflammation and CNS-Injury After Mild Traumatic Brain Injury JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM PY - 2024 PG - 17 SN - 0897-7151 DO - 10.1089/neu.2023.0419 UR - https://m2.mtmt.hu/api/publication/34615957 ID - 34615957 N1 - Export Date: 28 February 2024; CODEN: JNEUE AB - The aim of our study was to investigate the biological underpinnings of persistent post-concussion symptoms (PPCS) at 3 months following mild traumatic brain injury (mTBI). Patients (n = 192, age 16-60 years) with mTBI, defined as Glasgow Coma Scale (GCS) score between 13 and 15, loss of consciousness (LOC) <30 min, and post-traumatic amnesia (PTA) <24 h were included. Blood samples were collected at admission (within 72 h), 2 weeks, and 3 months. Concentrations of blood biomarkers associated with central nervous system (CNS) damage (glial fibrillary acidic protein [GFAP], neurofilament light [NFL], and tau) and inflammation (interferon gamma [IFN gamma], interleukin [IL]-8, eotaxin, macrophage inflammatory protein-1-beta [MIP]-1 beta, monocyte chemoattractant protein [MCP]-1, interferon-gamma-inducible protein [IP]-10, IL-17A, IL-9, tumor necrosis factor [TNF], basic fibroblast growth factor [FGF]-basic platelet-derived growth factor [PDGF], and IL-1 receptor antagonist [IL-1ra]) were obtained. Demographic and injury-related factors investigated were age, sex, GCS score, LOC, PTA duration, traumatic intracranial finding on magnetic resonance imaging (MRI; within 72 h), and extracranial injuries. Delta values, that is, time-point differences in biomarker concentrations between 2 weeks minus admission and 3 months minus admission, were also calculated. PPCS was assessed with the British Columbia Post-Concussion Symptom Inventory (BC-PSI). In single variable analyses, longer PTA duration and a higher proportion of intracranial findings on MRI were found in the PPCS group, but no single biomarker differentiated those with PPCS from those without. In multi-variable models, female sex, longer PTA duration, MRI findings, and lower GCS scores were associated with increased risk of PPCS. Inflammation markers, but not GFAP, NFL, or tau, were associated with PPCS. At admission, higher concentrations of IL-8 and IL-9 and lower concentrations of TNF, IL-17a, and MCP-1 were associated with greater likelihood of PPCS; at 2 weeks, higher IL-8 and lower IFN gamma were associated with PPCS; at 3 months, higher PDGF was associated with PPCS. Higher delta values of PDGF, IL-17A, and FGF-basic at 2 weeks compared with admission, MCP-1 at 3 months compared with admission, and TNF at 2 weeks and 3 months compared with admission were associated with greater likelihood of PPCS. Higher IL-9 delta values at both time-point comparisons were negatively associated with PPCS. Discriminability of individual CNS-injury and inflammation biomarkers for PPCS was around chance level, whereas the optimal combination of biomarkers yielded areas under the curve (AUCs) between 0.62 and 0.73. We demonstrate a role of biological factors on PPCS, including both positive and negative effects of inflammation biomarkers that differed based on sampling time-point after mTBI. PPCS was associated more with acute inflammatory processes, rather than ongoing inflammation or CNS-injury biomarkers. However, the modest discriminative ability of the models suggests other factors are more important in the development of PPCS. LA - English DB - MTMT ER - TY - JOUR AU - Abutarboush, Rania AU - Reed, Eileen AU - Chen, Ye AU - Gu, Ming AU - Watson, Cameron AU - Kawoos, Usmah AU - Statz, Jonathan K. AU - Tschiffely, Anna E. AU - Ciarlone, Stephanie AU - Perez-Garcia, Georgina AU - Gama Sosa, Miguel A. AU - de Gasperi, Rita AU - Stone, James R. AU - Elder, Gregory A. AU - Ahlers, Stephen T. TI - Exposure to Low-Intensity Blast Increases Clearance of Brain Amyloid Beta JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM PY - 2024 PG - 20 SN - 0897-7151 DO - 10.1089/neu.2023.0284 UR - https://m2.mtmt.hu/api/publication/34610764 ID - 34610764 N1 - Export Date: 28 February 2024; CODEN: JNEUE AB - The long-term effects of exposure to blast overpressure are an important health concern in military personnel. Increase in amyloid beta (A beta) has been documented after non-blast traumatic brain injury (TBI) and may contribute to neuropathology and an increased risk for Alzheimer's disease. We have shown that A beta levels decrease following exposure to a low-intensity blast overpressure event. To further explore this observation, we examined the effects of a single 37 kPa (5.4 psi) blast exposure on brain A beta levels, production, and clearance mechanisms in the acute (24 h) and delayed (28 days) phases post-blast exposure in an experimental rat model. A beta and, notably, the highly neurotoxic detergent soluble A beta 42 form, was reduced at 24 h but not 28 days after blast exposure. This reduction was not associated with changes in the levels of A beta oligomers, expression levels of amyloid precursor protein (APP), or increase in enzymes involved in the amyloidogenic cleavage of APP, the beta- and Gamma-secretases BACE1 and presenilin-1, respectively. The levels of ADAM17 alpha-secretase (also known as tumor necrosis factor alpha-converting enzyme) decreased, concomitant with the reduction in brain A beta. Additionally, significant increases in brain levels of the endothelial transporter, low-density related protein 1 (LRP1), and enhancement in co-localization of aquaporin-4 (AQP4) to perivascular astrocytic end-feet were observed 24 h after blast exposure. These findings suggest that exposure to low-intensity blast may enhance endothelial clearance of A beta by LRP1-mediated transcytosis and alter AQP4-aided glymphatic clearance. Collectively, the data demonstrate that low-intensity blast alters enzymatic, transvascular, and perivascular clearance of A beta. LA - English DB - MTMT ER - TY - JOUR AU - Bouchard, H.C. AU - Higgins, K.L. AU - Amadon, G.K. AU - Laing-Young, J.M. AU - Maerlender, A. AU - Al-Momani, S. AU - Neta, M. AU - Savage, C.R. AU - Schultz, D.H. TI - Concussion-Related Disruptions to Hub Connectivity in the Default Mode Network Are Related to Symptoms and Cognition JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM PY - 2024 SN - 0897-7151 DO - 10.1089/neu.2023.0089 UR - https://m2.mtmt.hu/api/publication/34561074 ID - 34561074 N1 - Center for Brain, Biology and Behavior, University of Nebraska-Lincoln, Lincoln, NE, United States Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, United States Department of Athletics, University of Nebraska-Lincoln, Lincoln, NE, United States Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States Export Date: 6 February 2024 CODEN: JNEUE Correspondence Address: Bouchard, H.C.; University of Nebraska-Lincoln, 328 Burnett Hall, United States; email: bbouchard2@huskers.unl.edu LA - English DB - MTMT ER - TY - JOUR AU - Tashiro, Akimasa AU - Bereiter, David A. AU - Ohta, Hiroyuki AU - Kawauchi, Satoko AU - Sato, Shunichi AU - Morimoto, Yuji TI - Trigeminal Sensitization in a Closed Head Model for Mild Traumatic Brain Injury JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 2024-1 PY - 2024 SN - 0897-7151 DO - 10.1089/neu.2023.0328 UR - https://m2.mtmt.hu/api/publication/34482706 ID - 34482706 N1 - Export Date: 28 February 2024; CODEN: JNEUE LA - English DB - MTMT ER - TY - JOUR AU - Trivedi, Dhanisha Trivedi AU - Forssten, Maximilian Peter AU - Cao, Yang AU - Mohammad Ismail, Ahmad AU - Czeiter, Endre AU - Amrein, Krisztina AU - Kobeissy, Firas AU - Wang, Kevin K W AU - DeSoucy, Erik AU - Büki, András AU - Mohseni, Shahin TI - Screening Performance of S100B, GFAP and UCH-L1 For Intracranial Injury Within 6 hours of Injury and beyond JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 41 PY - 2024 IS - 3-4 SP - 349 EP - 358 PG - 10 SN - 0897-7151 DO - 10.1089/neu.2023.0322 UR - https://m2.mtmt.hu/api/publication/34477399 ID - 34477399 N1 - * Megosztott szerzőség AB - The Scandinavian NeuroTrauma Committee (SNC) guidelines recommend S100B as a screening tool for early detection of Traumatic brain injury (TBI) in patients presenting with an initial Glasgow coma scale (GCS) of 14-15. The objective of the current study was to compare S100B's diagnostic performance within the recommended 6-hour window after injury, compared to GFAP and UCH-L1. The secondary outcome of interest was the ability of these biomarkers in detecting traumatic intracranial pathology beyond the 6-hour mark.The Center-TBI core database (2014-2017) was queried for data pertaining to all TBI patients with an initial GCS of 14-15 who had a blood sample taken within 6 hours of injury in which the levels of S100B, GFAP, and UCH-L1 were measured. As a subgroup analysis, data involving patients with blood samples taken within 6-9 hours, and 9-12 hours were analyzed separately for diagnostic ability. The diagnostic ability of these biomarkers for detecting any intracranial injury was evaluated based on the area under the receiver operating characteristic curve (AUC). Each biomarker's sensitivity, specificity, and accuracy were also reported at the cutoff that maximized Youden's index.A total of 531 TBI patients with GCS 14-15 on admission had a blood sample taken within 6 hours, of whom 24.9% (N = 132) had radiologically confirmed intracranial injury. The AUCs of GFAP (0.86, 95% confidence interval (CI): 0.82-0.90) and UCH-L1 (0.81, 95% CI: 0.76-0.85) were statistically significantly higher than that of S100B (0.74, 95% CI: 0.69-0.79) during this time. There was no statistically significant difference in the predictive ability of S100B when sampled within 6 hours, 6-9 hours, and 9-12 hours of injury, as the p-values were >0.05 when comparing the AUCs. Overlapping AUC 95% CI suggests no benefit of a combined GFAP and UCH-L1 screening tool over GFAP during the time periods studied [ 0.87 (0.83-0.90) vs 0.86 (0.82-0.90) when sampled within 6 hours of injury, 0.83 (0.78-0.88) vs 0.83 (0.78-0.89) within 6-to-9 hours and 0.81 (0.73-0.88) vs 0.79 (0.72-0.87) within 9-12 hours].Targeted analysis of the CENTER-TBI core database, with focus on the patient category for which biomarker testing is recommended by the SNC guidelines, revealed that GFAP and UCH-L1 perform superior to S100B in predicting CT-positive intracranial lesions within 6 hours of injury. GFAP continued to exhibit superior predictive ability to S100B during the time periods studied. S100B displayed relatively unaltered screening performance beyond the diagnostic timeline provided by SNC guidelines. These findings suggest the need for a re-evaluation of the current SNC TBI guidelines. LA - English DB - MTMT ER - TY - JOUR AU - Gusdon, A.M. AU - Savarraj, J.P.J. AU - Redell, J.B. AU - Paz, A. AU - Hinds, S. AU - Burkett, A. AU - Torres, G. AU - Ren, X. AU - Badjatia, N. AU - Hergenroeder, G.W. AU - Moore, A.N. AU - Choi, H.A. AU - Dash, P.K. TI - Lysophospholipids Are Associated With Outcomes in Hospitalized Patients With Mild Traumatic Brain Injury JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 41 PY - 2024 IS - 1-2 SP - 59 EP - 72 PG - 14 SN - 0897-7151 DO - 10.1089/neu.2023.0046 UR - https://m2.mtmt.hu/api/publication/34562183 ID - 34562183 N1 - Division of Neurocritical Care, Department of Neurosurgery, McGovern School of Medicine, University of Texas, Health Science Center, Houston, TX, United States Department of Neurobiology and Anatomy, McGovern School of Medicine, University of Texas, Health Science Center, Houston, TX, United States Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States Cited By :1 Export Date: 6 February 2024 CODEN: JNEUE Correspondence Address: Dash, P.K.; Department of Neurobiology and Anatomy, 6431 Fannin Street, MSB 7.046, United States; email: P.Dash@uth.tmc.edu LA - English DB - MTMT ER -