@article{MTMT:34643267, title = {Defining Standards for Hepatopancreatobiliary Cancer Surgery in Ontario, Canada: A Population-Based Cohort Study of Clinical Outcomes}, url = {https://m2.mtmt.hu/api/publication/34643267}, author = {Hirpara, Dhruvin H. and Irish, Jonathan and Rashid, Mohammed and Martin, Tharsiya and Zhu, Alice and Hunter, Amber and Jayaraman, Shiva and Wei, Alice C. and Coburn, Natalie G. and Wright, Frances C.}, doi = {10.1097/XCS.0000000000000885}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {238}, unique-id = {34643267}, issn = {1072-7515}, year = {2024}, eissn = {1879-1190}, pages = {157-165} } @article{MTMT:33780840, title = {Effects of Patient Sex on Neurocognitive Decline after Cardiac Surgery}, url = {https://m2.mtmt.hu/api/publication/33780840}, author = {Stanley, Madigan E and Kant, Shawn and Raker, Chris and Sabe, Sharif and Sodha, Neel R and Ehsan, Afshin and Sellke, Frank W}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {10}, unique-id = {33780840}, issn = {1072-7515}, year = {2023}, eissn = {1879-1190}, pages = {10-1097} } @article{MTMT:34366711, title = {Disparity in Breast Cancer Care: Current State of Access to Screening, Genetic Testing, Oncofertility, and Reconstruction}, url = {https://m2.mtmt.hu/api/publication/34366711}, author = {Crown, Angelena and Fazeli, Soudabeh and Kurian, Allison W. and Ochoa, Daniela A. and Joseph, Kathie-Ann}, doi = {10.1097/XCS.0000000000000647}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {236}, unique-id = {34366711}, issn = {1072-7515}, abstract = {Breast cancer is the most common cancer diagnosed in women, accounting for an estimated 30% of all new cancer diagnoses in women in 2022. Advances in breast cancer treatment have reduced the mortality rate over the past 25 years by up to 34% but not all groups have benefitted equally from these improvements. These disparities span the continuum of care from screening to the receipt of guideline-concordant therapy and survivorship. At the 2022 American College of Surgeons Clinical Congress, a panel session was dedicated to educating and discussing methods of addressing these disparities in a coordinated manner. While there are multilevel solutions to address these disparities, this article focuses on screening, genetic testing, reconstruction, and oncofertility.}, year = {2023}, eissn = {1879-1190}, pages = {1233-1239} } @article{MTMT:34345945, title = {Effect of Patient Sex on Neurocognitive Decline after Cardiac Surgery}, url = {https://m2.mtmt.hu/api/publication/34345945}, author = {Stanley, Madigan E. and Kant, Shawn and Raker, Christina and Sabe, Sharif and Sodha, Neel R. and Ehsan, Afshin and Sellke, Frank W.}, doi = {10.1097/XCS.0000000000000574}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {236}, unique-id = {34345945}, issn = {1072-7515}, abstract = {BACKGROUND: Neurocognitive decline (NCD) is a common complication of cardiac surgery. Understanding risk factors helps surgeons counsel patients pre-and perioperatively about risk, prevention, and treatment.STUDY DESIGN: Patients undergoing cardiac surgery using cardiopulmonary bypass underwent pre-and postoperative neurocognitive testing. Neurocognitive data are presented as a change from baseline to either postoperative day 4 or to 1 month. The score is standardized with respect to age.RESULTS: Eighty-four patients underwent surgery and completed postoperative neurocognitive testing. There was no significant difference in baseline neurocognitive function. NCD was more common in female patients (71%) than male patients (26.4%) on postoperative day 4. By 1 month, the incidence of NCD is similar between female (15.0%) and male patients (14.3%). Of note, female patients differed from male patients in preoperative hematocrit, preoperative creatinine, and type of surgery.CONCLUSIONS: In the acute postoperative period, female patients are both more likely to experience NCD and experience a more severe change from baseline cognitive function. This difference between male and female patients resolves by the 1 month follow-up point. Female patients had a lower preoperative hematocrit and were more likely to receive intraoperative and perioperative blood transfusion. Lower preoperative hematocrit appears to mediate the difference in NCD between male and female patients. (C) 2023 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.)}, year = {2023}, eissn = {1879-1190}, pages = {1112-1124} } @article{MTMT:34248653, title = {Effectiveness of Single Chest Tube vs Double Chest Tube Application Postdecortication: Prospective Randomized Controlled Study}, url = {https://m2.mtmt.hu/api/publication/34248653}, author = {Hart, Jonathan Minagogo and Hussien, Anwar Mohammed and Tesfaye, Samuel and Nadamo, Siyasebew Mamo and Senbu, Mekonnen Feyissa and Wadaja, Desalegn Fekadu and Bacha, Isreal Tadesse and Tebeje, Hiwot Gebeyehu}, doi = {10.1097/XCS.0000000000000661}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {236}, unique-id = {34248653}, issn = {1072-7515}, abstract = {BACKGROUND: Draining the chest cavity with 2 tubes is a common practice among thoracic surgeons. This research was conducted in Addis Ababa from March 2021 to May 2022. A total of 62 patients were included. STUDY DESIGN: This study was conducted to investigate the superiority of either single or double tube insertion after decortication. Patients were randomized in a ratio of 1:1. In group A, 2 tubes were inserted; in group B, single 32F tubes were inserted. Statistical analyses were performed using Statistical Package for Social Sciences version 27.0, Student's t test and Pearson chi-square test. RESULTS: The age range of patients was 18 to 70 years, with a mean of 44 +/- 14.4434 years; the male to female ratio was 2.9:1. The dominant underlying pathologies were tuberculosis and trauma (45.2% vs 35.5%); the right side was more involved (62.3%). Drain output was 1,465 +/- 1,887.9751 mL in group A vs 1,018 +/- 802.5662 mL in group B (p value = 0.00001); the duration of drains was 7.5498 +/- 11.3137 days in group A vs 3.8730 +/- 1.4142 days in group B (p value = 0.000042). The degree of pain was 2.6458 +/- 4.2426 vs 2.000 +/- 2.1213 in group A and group B, respectively (p value = 0.326757). The length of hospital stay was 21.5818 +/- 11.9791 days in group A vs 13.6091 +/- 6.2048 days in group B (p value = 0.00001). Group A had air leak of 90.3% vs 74.2% in group B; subcutaneous emphysema was 9.7% in group A and 12.9% in group B. There was no fluid recollection, and no patients required tube reinsertion. CONCLUSIONS: The placement of a single tube after decortication is effective in reducing drain output, time of drain, and hospital stay. There was no association with pain, and there was no effect on other endpoints. ( J Am Coll Surg 2023;236:1217-1231. (c) 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Surgeons. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 [CCBY-NC-ND], where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.)}, year = {2023}, eissn = {1879-1190}, pages = {1217-1231} } @article{MTMT:34391845, title = {Angioembolization and Adding Insult to Operative Hepatic Injury}, url = {https://m2.mtmt.hu/api/publication/34391845}, author = {Dilday, Joshua and Martin, Matthew J.}, doi = {10.1097/XCS.0000000000000803}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {237}, unique-id = {34391845}, issn = {1072-7515}, year = {2023}, eissn = {1879-1190}, pages = {703-705} } @article{MTMT:34352342, title = {Disparity and Variation in Esophageal Cancer Surgery}, url = {https://m2.mtmt.hu/api/publication/34352342}, author = {Wang, Kevin J. and Worrell, Stephanie G.}, doi = {10.1097/XCS.0000000000000805}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {237}, unique-id = {34352342}, issn = {1072-7515}, year = {2023}, eissn = {1879-1190}, pages = {785-787} } @article{MTMT:34311816, title = {There Is No Such Thing as Too Soon: Long-Term Outcomes of Early Cholecystectomy for Frail Geriatric Patients with Acute Biliary Pancreatitis}, url = {https://m2.mtmt.hu/api/publication/34311816}, author = {Nelson, Adam C. and Bhogadi, Sai Krishna and Hosseinpour, Hamidreza and Stewart, Collin and Anand, Tanya and Spencer, Audrey L. and Colosimo, Christina and Magnotti, Louis J. and Joseph, Bellal}, doi = {10.1097/XCS.0000000000000790}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {237}, unique-id = {34311816}, issn = {1072-7515}, abstract = {BACKGROUND: Early cholecystectomy (CCY) for acute biliary pancreatitis (ABP) is recommended but there is a paucity of data assessing this approach in frail geriatric patients. This study compares outcomes of frail geriatric ABP patients undergoing index admission CCY vs nonoperative management (NOM) with endoscopic retrograde cholangiopancreatography (ERCP).STUDY DESIGN: Retrospective analysis of the Nationwide Readmissions Database (2017). All frail geriatric (65 years or older) patients with ABP were included. Patients were grouped by treatment at index admission: CCY vs NOM with endoscopic retrograde cholangiopancreatography. Propensity score matching was performed in a 1:2 ratio. Primary outcomes were 6-month readmissions, mortality, and length of stay. Secondary outcomes were 6-month failure of NOM defined as readmission for recurrent ABP, unplanned pancreas-related procedures, or unplanned CCY. Subanalysis was performed to compare outcomes of unplanned CCY vs early CCY.RESULTS: A total of 29,130 frail geriatric patients with ABP were identified and 7,941 were matched (CCY 5,294; NOM 2,647). Patients in the CCY group had lower 6-month rates of readmission for pancreas-related complications, unplanned readmissions for pancreas-related procedures, overall readmissions, and mortality, as well as fewer hospitalized days (p < 0.05). NOM failed in 12% of patients and 7% of NOM patients were readmitted within 6 months to undergo CCY, of which 56% were unplanned. Patients who underwent unplanned CCY had higher complication rates and hospital costs, longer hospital lengths of stay, and increased mortality compared with early CCY (p < 0.05).CONCLUSIONS: For frail geriatric patients with ABP, early CCY was associated with lower 6-month rates of complications, readmissions, mortality, and fewer hospitalized days. NOM was unsuccessful in nearly 1 of 7 within 6 months; of these, one-third required unplanned CCY. Early CCY should be prioritized for frail geriatric ABP patients when feasible.}, year = {2023}, eissn = {1879-1190}, pages = {712-718} } @article{MTMT:34206550, title = {Increased Variation in Esophageal Cancer Treatment and Geographic Healthcare Disparity in Michigan}, url = {https://m2.mtmt.hu/api/publication/34206550}, author = {Lee, John H and Arora, Akul and Bergman, Rachel and Gomez-Rexrode, Amalia and Sidhom, David and Reddy, Rishindra M}, doi = {10.1097/XCS.0000000000000819}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {237}, unique-id = {34206550}, issn = {1072-7515}, year = {2023}, eissn = {1879-1190}, pages = {779-785} } @article{MTMT:33848231, title = {PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory Response and Cardiac Function}, url = {https://m2.mtmt.hu/api/publication/33848231}, author = {Wen, Jake J. and Dejesus, Jana E. and Radhakrishnan, Geetha L. and Radhakrishnan, Ravi S.}, doi = {10.1097/XCS.0000000000000546}, journal-iso = {J AM COLL SURGEONS}, journal = {JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS}, volume = {236}, unique-id = {33848231}, issn = {1072-7515}, abstract = {BACKGROUND: Burn injury induces multiple signaling pathways leading to a significant inflammatory storm that adversely affects multiple organs, including the heart. Poly (ADP-ribose) polymerase inhibitor 1 (PARP1) inhibition, with specific agents such as N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide (PJ34), is effective in reducing oxidative stress and cytokine expression in the heart. We hypothesized that PARP1 inhibition would reduce inflammatory signaling and protect against burn injury-induced cardiac dysfunction.STUDY DESIGN: Male Sprague-Dawley rats (8 weeks old, 300 to 350 g) were randomly assigned to sham injury (Sham), 60% total body surface area burn (24 hours post burn), or 60% total body surface area burn with intraperitoneal administration of PJ34 (20 mg/kg, 24 hours post burn + PJ34) and sacrificed 24 hours after injury. Cardiac function was determined using Vevo 2100 echocardiography. Genetic expression of 84 specific toll-like receptor-mediated signal transduction and innate immunity genes were examined using microarray to evaluate cardiac tissue. Qiagen GeneGlobe Data Analysis Center was used to analyze expression, and genetic clustering was performed using TreeView V2.0.8 software. Real-time quantitative polymerase chain reaction was used to validate identified differentially expressed genes.RESULTS: Burn injury significantly altered multiple genes in the toll-like receptor signaling, inter-leukin-17 signaling, tumor necrosis factor signaling, and nuclear factor-kappa B signaling path-ways and led to significant cardiac dysfunction. PARP1 inhibition with PJ34 normalized these signaling pathways to sham levels as well as improved cardiac function to sham levels.CONCLUSIONS: PARP1 inhibition normalizes multiple inflammatory pathways that are altered after burn injury and improves cardiac dysfunction. PARP1 pathway inhibition may provide a novel methodology to normalize multiple burn injury-induced inflammatory pathways in the heart. (J Am Coll Surg 2023;236:783-802. (c) 2023 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved. )}, year = {2023}, eissn = {1879-1190}, pages = {783-802} }