TY - JOUR AU - Guidet, Bertrand AU - Vallet, Helene AU - Flaatten, Hans AU - Joynt, Gavin AU - Bagshaw, Sean M. AU - Leaver, Susannah K. AU - Beil, Michael AU - Du, Bin AU - Forte, Daniel N. AU - Angus, Derek C. AU - Sviri, Sigal AU - de Lange, Dylan AU - Herridge, Margaret S. AU - Jung, Christian TI - The trajectory of very old critically ill patients JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED PY - 2024 PG - 14 SN - 0342-4642 DO - 10.1007/s00134-023-07298-z UR - https://m2.mtmt.hu/api/publication/34663792 ID - 34663792 LA - English DB - MTMT ER - TY - JOUR AU - Turella, Sara AU - Dankiewicz, Josef AU - Friberg, Hans AU - Jakobsen, Janus Christian AU - Leithner, Christoph AU - Levin, Helena AU - Lilja, Gisela AU - Moseby-Knappe, Marion AU - Nielsen, Niklas AU - Rossetti, Andrea O. AU - Sandroni, Claudio AU - Zubler, Frederic AU - Cronberg, Tobias AU - Westhall, Erik TI - The predictive value of highly malignant EEG patterns after cardiac arrest: evaluation of the ERC-ESICM recommendations JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED PY - 2024 PG - 13 SN - 0342-4642 DO - 10.1007/s00134-023-07280-9 UR - https://m2.mtmt.hu/api/publication/34660292 ID - 34660292 LA - English DB - MTMT ER - TY - JOUR AU - Robba, Chiara AU - Battaglini, Denise AU - Abbas, Abbas AU - Sarrio, Ezequiel AU - Cinotti, Raphael AU - Asehnoune, Karim AU - Taccone, Fabio S. AU - Rocco, Patricia R. AU - Schultz, Marcus J. AU - Citerio, Giuseppe AU - Stevens, Robert David AU - Badenes, Rafael TI - Clinical practice and effect of carbon dioxide on outcomes in mechanically ventilated acute brain-injured patients: a secondary analysis of the ENIO study JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED PY - 2024 PG - 13 SN - 0342-4642 DO - 10.1007/s00134-023-07305-3 UR - https://m2.mtmt.hu/api/publication/34640248 ID - 34640248 LA - English DB - MTMT ER - TY - JOUR AU - Kreitmann, Louis AU - Helms, Julie AU - Martin-Loeches, Ignacio AU - Salluh, Jorge AU - Poulakou, Garyphallia AU - Pene, Frederic AU - Nseir, Saad TI - ICU-acquired infections in immunocompromised patients JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED PY - 2024 PG - 18 SN - 0342-4642 DO - 10.1007/s00134-023-07295-2 UR - https://m2.mtmt.hu/api/publication/34604223 ID - 34604223 N1 - Export Date: 28 February 2024; CODEN: ICMED AB - Immunocompromised patients account for an increasing proportion of the typical intensive care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and auto-immune diseases, and improvement in the care of the most severely immunocompromised ICU patients (including those with hematologic malignancies), critically ill immunocompromised patients form a highly heterogeneous patient population. Furthermore, a large number of ICU patients with no apparent immunosuppression also harbor underlying conditions altering their immune response, or develop ICU-acquired immune deficiencies as a result of sepsis, trauma or major surgery. While infections are associated with significant morbidity and mortality in immunocompromised critically ill patients, little specific data are available on the incidence, microbiology, management and outcomes of ICU-acquired infections in this population. As a result, immunocompromised patients are usually excluded from trials and guidelines on the management of ICU-acquired infections. The most common ICU-acquired infections in immunocompromised patients are ventilator-associated lower respiratory tract infections (which include ventilator-associated pneumonia and tracheobronchitis) and bloodstream infections. Recently, several large observational studies have shed light on some of the epidemiological specificities of these infections-as well as on the dynamics of colonization and infection with multidrug-resistant bacteria-in these patients, and these will be discussed in this review. Immunocompromised patients are also at higher risk than non-immunocompromised hosts of fungal and viral infections, and the diagnostic and therapeutic management of these infections will be covered. Finally, we will suggest some important areas of future investigation. LA - English DB - MTMT ER - TY - JOUR AU - Maier, C.L. AU - Brohi, K. AU - Curry, N. AU - Juffermans, N.P. AU - Miquel, L.M. AU - Neal, M.D. AU - Shaz, B.H. AU - Vlaar, A.P.J. AU - Helms, J. TI - Contemporary management of major haemorrhage in critical care JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED VL - In press PY - 2024 SP - In press SN - 0342-4642 DO - 10.1007/s00134-023-07303-5 UR - https://m2.mtmt.hu/api/publication/34509518 ID - 34509518 N1 - Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA, United States Centre for Trauma Sciences, Queen Mary University of London, London, United Kingdom Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom Nuffield Department of Clinical and Laboratory Sciences, Radcliffe Department of Medicine, Oxford University, Oxford, United Kingdom Department of Intensive Care and Laboratory of Translational Intensive Care, Erasmus Medical Center, Rotterdam, Netherlands Department of Anaesthesiology, Intensive Care and Pain Clinic, Vall d’Hebron Trauma, Rehabilitation and Burns Hospital, Autonomous University of Barcelona, Passeig de La Vall d’Hebron 119-129, Barcelona, 08035, Spain Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, PA, United States Department of Pathology, Duke University School of Medicine, Durham, NC, United States Amsterdam University Medical Centers, Amsterdam, Netherlands Service de Médecine Intensive-Réanimation, Department of Intensive Care, Nouvel Hôpital Civil, Université de Strasbourg (UNISTRA), 1, Place de L’Hôpital, Strasbourg Cedex, 67091, France Export Date: 17 January 2024 CODEN: ICMED Correspondence Address: Helms, J.; Service de Médecine Intensive-Réanimation, Place de L’Hôpital, France; email: Julie.helms@chru-strasbourg.fr LA - English DB - MTMT ER - TY - JOUR AU - Pérez-Blanco, A. AU - Manara, A. TI - Intensive care admission aiming at organ donation. Pro JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED VL - 50 PY - 2024 IS - 3 SP - 437 EP - 439 PG - 3 SN - 0342-4642 DO - 10.1007/s00134-024-07334-6 UR - https://m2.mtmt.hu/api/publication/34775604 ID - 34775604 N1 - Export Date: 8 April 2024 CODEN: ICMED Correspondence Address: Pérez-Blanco, A.; Organización Nacional de Trasplantes, C/Sinesio Delgado, 6-8 Pabellón 3, Spain; email: aperezb@sanidad.gob.es LA - English DB - MTMT ER - TY - JOUR AU - Meersch, Melanie AU - Weiss, Raphael AU - Strauss, Christian AU - Albert, Felix AU - Booke, Hendrik AU - Forni, Lui AU - Pittet, Jean-Francois AU - Kellum, John A. AU - Rosner, Mitchell AU - Mehta, Ravindra AU - Bellomo, Rinaldo AU - Rosenberger, Peter AU - Zarbock, Alexander TI - Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED VL - 50 PY - 2024 IS - 2 SP - 247 EP - 257 PG - 11 SN - 0342-4642 DO - 10.1007/s00134-023-07314-2 UR - https://m2.mtmt.hu/api/publication/34649761 ID - 34649761 N1 - Export Date: 28 February 2024; CODEN: ICMED LA - English DB - MTMT ER - TY - JOUR AU - Dumas, G. AU - Arabi, Y.M. AU - Bartz, R. AU - Ranzani, O. AU - Scheibe, F. AU - Darmon, M. AU - Helms, J. TI - Diagnosis and management of autoimmune diseases in the ICU JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED VL - 50 PY - 2024 IS - 1 SP - 17 EP - 35 PG - 19 SN - 0342-4642 DO - 10.1007/s00134-023-07266-7 UR - https://m2.mtmt.hu/api/publication/34492974 ID - 34492974 N1 - Medical Intensive Care Unit, Service de Médecine Intensive-Réanimation, CHU Grenoble-Alpes, Université Grenoble-Alpes, INSERM, Grenoble, U1042-HP2, France Intensive Care Department, Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia King Abdullah International Medical Research Center, Riyadh, Saudi Arabia King Saud Bin Abdulaziz University for Health Sciences Riyadh, Riyadh, Saudi Arabia Department of Anesthesia, Perioperative, and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States Barcelona Institute for Global Health, ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain Pulmonary Division, Faculdade de Medicina, Heart Institute, InCor, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil Department of Neurology and Experimental Neurology, Charité– Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany NeuroCure Clinical Research Center, Charité–Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany Medical Intensive Care Unit, APHP, Hôpital Saint-Louis, Famirea Study Group, ECSTRA Team, and Clinical EpidemiologyUMR 1153, Center of Epidemiology and Biostatistics, Sorbonne Paris Cité, CRESS, INSERM, Université Paris Cité, Paris, France Faculté de Médecine, Service de Médecine Intensive-Réanimation, Université de Strasbourg (UNISTRA), Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, 1 Place de L’Hôpital, Strasbourg, France Export Date: 30 January 2024 CODEN: ICMED Correspondence Address: Dumas, G.; Medical Intensive Care Unit, France; email: Dumas.guillaume1@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Rossetti, Andrea O. AU - Claassen, Jan AU - Gaspard, Nicolas TI - Status epilepticus in the ICU JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED PY - 2023 PG - 16 SN - 0342-4642 DO - 10.1007/s00134-023-07263-w UR - https://m2.mtmt.hu/api/publication/34637539 ID - 34637539 LA - English DB - MTMT ER - TY - JOUR AU - Burns, Karen E. A. AU - Cook, Deborah J. AU - Xu, Keying AU - Dodek, Peter AU - Villar, Jesus AU - Jones, Andrew AU - Kapadia, Farhad N. AU - Gattas, David J. AU - Epstein, Scott K. AU - Pelosi, Paolo AU - Kefala, Kallirroi AU - Meade, Maureen O. AU - Rizvi, Leena AU - Canadian Critical Care Trials Grp, . TI - Differences in directives to limit treatment and discontinue mechanical ventilation between elderly and very elderly patients: a substudy of a multinational observational study JF - INTENSIVE CARE MEDICINE J2 - INTENS CARE MED PY - 2023 PG - 10 SN - 0342-4642 DO - 10.1007/s00134-023-07188-4 UR - https://m2.mtmt.hu/api/publication/34362267 ID - 34362267 AB - Purpose: The aim of this study was to characterize differences in directives to limit treatments and discontinue invasive mechanical ventilation (IMV) in elderly (65-80 years) and very elderly (> 80 years) intensive care unit (ICU) patients.Methods: We prospectively described new written orders to limit treatments, IMV discontinuation strategies [direct extubation, direct tracheostomy, spontaneous breathing trial (SBT), noninvasive ventilation (NIV) use], and associations between initial failed SBT and outcomes in 142 ICUs from 6 regions (Canada, India, United Kingdom, Europe, Australia/New Zealand, United States).Results: We evaluated 788 (586 elderly; 202 very elderly) patients. Very elderly (vs. elderly) patients had similar withdrawal orders but significantly more withholding orders, especially cardiopulmonary resuscitation and dialysis, after ICU admission [67 (33.2%) vs. 128 (21.9%); p = 0.002]. Orders to withhold reintubation were written sooner in very elderly (vs. elderly) patients [4 (2-8) vs. 7 (4-13) days, p = 0.02]. Very elderly and elderly patients had similar rates of direct extubation [39 (19.3%) vs. 113 (19.3%)], direct tracheostomy [10 (5%) vs. 40 (6.8%)], initial SBT [105 (52%) vs. 302 (51.5%)] and initial successful SBT [84 (80%) vs. 245 (81.1%)]. Very elderly patients experienced similar ICU outcomes (mortality, length of stay, duration of ventilation) but higher hospital mortality [26 (12.9%) vs. 38 (6.5%)]. Direct tracheostomy and initial failed SBT were associated with worse outcomes. Regional differences existed in withholding orders at ICU admission and in withholding and withdrawal orders after ICU admission.Conclusions: Very elderly (vs. elderly) patients had more orders to withhold treatments after ICU admission and higher hospital mortality, but similar ICU outcomes and IMV discontinuation. Significant regional differences existed in withholding and withdrawal practices. LA - English DB - MTMT ER -