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Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA, United States
Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, United States
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Correspondence Address: Sehgal, A.; Department of Neuroscience, United States; email: amita@pennmedicine.upenn.edu
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<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, United States
Chronobiology and Sleep Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States
Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA, United States
Children’s Hos...</pre>
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;
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;
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;
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;
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;
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34615663" target="_blank">The logic of recurrent circuits in the primary visual cortex</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span>
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Episodic memories are encoded by experience-activated neuronal ensembles that remain necessary and sufficient for recall. However, the temporal evolution of memory engrams after initial encoding is unclear. In this study, we employed computational and experimental approaches to examine how the neural composition and selectivity of engrams change with memory consolidation. Our spiking neural network model yielded testable predictions: memories transition from unselective to selective as neurons drop out of and drop into engrams; inhibitory activity during recall is essential for memory selectivity; and inhibitory synaptic plasticity during memory consolidation is critical for engrams to become selective. Using activity-dependent labeling, longitudinal calcium imaging and a combination of optogenetic and chemogenetic manipulations in mouse dentate gyrus, we conducted contextual fear conditioning experiments that supported our model's predictions. Our results reveal that memory engrams are dynamic and that changes in engram composition mediated by inhibitory plasticity are crucial for the emergence of memory selectivity.This paper shows that memory engrams are dynamic: neurons drop in and out as engrams become selective during memory consolidation. Inhibition and inhibitory plasticity are crucial for the expression and emergence of memory selectivity, respectively.
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34614999" target="_blank">Dynamic and selective engrams emerge with memory consolidation</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span>
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<div class="lastModified">Utolsó módosítás: 2024.02.18. 03:49 Szuper Admin (admin)
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Rabies-virus-based monosynaptic tracing is a widely used technique for mapping neural circuitry, but its cytotoxicity has confined it primarily to anatomical applications. Here we present a second-generation system for labeling direct inputs to targeted neuronal populations with minimal toxicity, using double-deletion-mutant rabies viruses. Viral spread requires expression of both deleted viral genes in trans in postsynaptic source cells. Suppressing this expression with doxycycline following an initial period of viral replication reduces toxicity to postsynaptic cells. Longitudinal two-photon imaging in vivo indicated that over 90% of both presynaptic and source cells survived for the full 12-week course of imaging. Ex vivo whole-cell recordings at 5 weeks postinfection showed that the second-generation system perturbs input and source cells much less than the first-generation system. Finally, two-photon calcium imaging of labeled networks of visual cortex neurons showed that their visual response properties appeared normal for 10 weeks, the longest we followed them.Rabies-virus-based tracing is a widely used technique for mapping neural circuitry, but its cytotoxicity has limited its applications. Here Jin et al. present a second-generation system with minimal toxicity, using double-deletion-mutant rabies viruses.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Jin, Lei </span> <span class="author-type"> </span> ; <span class="author-name" > Sullivan, Heather A. </span> <span class="author-type"> </span> ; <span class="author-name" > Zhu, Mulangma </span> <span class="author-type"> </span> ; <span class="author-name" > Lavin, Thomas K. </span> <span class="author-type"> </span> ; <span class="author-name" > Matsuyama, Makoto </span> <span class="author-type"> </span> ; <span class="author-name" > Fu, Xin </span> <span class="author-type"> </span> ; <span class="author-name" > Lea, Nicholas E. </span> <span class="author-type"> </span> ; <span class="author-name" > Xu, Ran </span> <span class="author-type"> </span> ; <span class="author-name" > Hou, Yuanyuan </span> <span class="author-type"> </span> ; <span class="author-name" > Rutigliani, Luca </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34614705" mtid="34614705" target="_blank">Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses</a></div> <div class="pub-info"> <span class="journal-title">NATURE NEUROSCIENCE</span> <span class="journal-volume"></span> <span class="page"> , 33 p. </span> <span class="year">(2024)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1038/s41593-023-01545-8" target="_blank" href="https://doi.org/10.1038/s41593-023-01545-8"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001140852900002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001140852900002"> WoS </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:34614705 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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;
<span class="author-name" >Pruner Maxwell
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;
<span class="author-name" >Babcock Kelsey R.
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;
<span class="author-name" >Ip Jacque Pak Kan
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;
<span class="author-name" >Hu Ming
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;
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;
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;
<span class="author-name" >Sur Mriganka
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;
<span class="author-name" >Feng Guoping
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;
<span class="author-name" >Wickersham Ian R. ✉
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34614705" target="_blank">Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span>
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Oligodendrocyte-axon metabolic coupling is mediated by extracellular K<SUP>+</SUP> and maintains axonal health
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The integrity of myelinated axons relies on homeostatic support from oligodendrocytes (OLs). To determine how OLs detect axonal spiking and how rapid axon-OL metabolic coupling is regulated in the white matter, we studied activity-dependent calcium (Ca2+) and metabolite fluxes in the mouse optic nerve. We show that fast axonal spiking triggers Ca2+ signaling and glycolysis in OLs. OLs detect axonal activity through increases in extracellular potassium (K+) concentrations and activation of Kir4.1 channels, thereby regulating metabolite supply to axons. Both pharmacological inhibition and OL-specific inactivation of Kir4.1 reduce the activity-induced axonal lactate surge. Mice lacking oligodendroglial Kir4.1 exhibit lower resting lactate levels and altered glucose metabolism in axons. These early deficits in axonal energy metabolism are associated with late-onset axonopathy. Our findings reveal that OLs detect fast axonal spiking through K+ signaling, making acute metabolic coupling possible and adjusting the axon-OL metabolic unit to promote axonal health.
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<span class="author-name" >Zanker Henri S.
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;
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;
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</span>
;
<span class="author-name" >Nave Klaus-Armin
</span>
;
<span class="author-name" >Weber Bruno
</span>
;
<span class="author-name" >Saab Aiman S. ✉
</span>
</div>
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34614702" target="_blank">Oligodendrocyte-axon metabolic coupling is mediated by extracellular K<SUP>+</SUP> and maintains axonal health</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span>
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The cerebellar cortex has a key role in generating predictive sensorimotor associations. To do so, the granule cell layer is thought to establish unique sensorimotor representations for learning. However, how this is achieved and how granule cell population responses contribute to behavior have remained unclear. To address these questions, we have used in vivo calcium imaging and granule cell-specific pharmacological manipulation of synaptic inhibition in awake, behaving mice. These experiments indicate that inhibition sparsens and thresholds sensory responses, limiting overlap between sensory ensembles and preventing spiking in many granule cells that receive excitatory input. Moreover, inhibition can be recruited in a stimulus-specific manner to powerfully decorrelate multisensory ensembles. Consistent with these results, granule cell inhibition is required for accurate cerebellum-dependent sensorimotor behavior. These data thus reveal key mechanisms for granule cell layer pattern separation beyond those envisioned by classical models.Using in vivo calcium imaging and cell-type-specific pharmacology, we reveal that synaptic inhibition in the cerebellar granule cell layer supports pattern separation and cerebellum-dependent behavior.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Fleming, Elizabeth A. </span> <span class="author-type"> </span> ; <span class="author-name" > Field, Greg D. </span> <span class="author-type"> </span> ; <span class="author-name" > Tadross, Michael R. </span> <span class="author-type"> </span> ; <span class="author-name" > Hull, Court ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34610473" mtid="34610473" target="_blank">Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations</a></div> <div class="pub-info"> <span class="journal-title">NATURE NEUROSCIENCE</span> <span class="journal-volume"></span> <span class="page"> , 20 p. </span> <span class="year">(2024)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1038/s41593-023-01565-4" target="_blank" href="https://doi.org/10.1038/s41593-023-01565-4"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001157612700002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001157612700002"> WoS </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:34610473 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Fleming Elizabeth A.
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;
<span class="author-name" >Field Greg D.
</span>
;
<span class="author-name" >Tadross Michael R.
</span>
;
<span class="author-name" >Hull Court ✉
</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34610473" target="_blank">Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span>
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Using in vivo imaging in zebrafish, we unveiled critical components (PSD-95, gephyrin and neuroligin-3) and dynamic properties of synapses between neurons and oligodendrocyte precursor cells (OPC). Furthermore, we showed that neuron-OPC synapses have a pivotal role in regulating OPC development and CNS myelination.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Li, Jiaxing ✉ </span> <span class="author-type"> </span> ; <span class="author-name" > Monk, Kelly R. </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34602281" mtid="34602281" target="_blank">Synapses shape oligodendrocyte precursor cell development and predict myelination location</a></div> <div class="pub-info"> <span class="journal-title">NATURE NEUROSCIENCE</span> <span class="journal-volume"></span> <span class="page"> , 2 p. </span> <span class="year">(2024)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1038/s41593-023-01555-6" target="_blank" href="https://doi.org/10.1038/s41593-023-01555-6"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001152768000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001152768000001"> WoS </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:34602281 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Li Jiaxing ✉
</span>
;
<span class="author-name" >Monk Kelly R.
</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34602281" target="_blank">Synapses shape oligodendrocyte precursor cell development and predict myelination location</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-6256">1097-6256</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1546-1726">1546-1726</a>)</span>:
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2 p.
</span> <span class="year">(2024)</span>
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Angol
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DOI
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<div class="lastModified">Utolsó módosítás: 2024.02.16. 20:50 Szuper Admin (admin)
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Head-direction (HD) neurons are thought to exclusively encode directional heading. In awake mice, we found that sensory stimuli evoked robust short-latency responses in thalamic HD cells, but not in non-HD neurons. The activity of HD cells, but not that of non-HD neurons, was tightly correlated to brain-state fluctuations and dynamically modulated during social interactions. These data point to a new role for the thalamic compass in relaying sensory and behavioral-state information.In this study the authors show that in the mouse anterior thalamus, the activity of head-direction cells is selectively modulated by sensory stimuli and by the animal's behavioral state.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Blanco-Hernandez, Eduardo </span> <span class="author-type"> </span> ; <span class="author-name" > Balsamo, Giuseppe </span> <span class="author-type"> </span> ; <span class="author-name" > Preston-Ferrer, Patricia ✉ </span> <span class="author-type"> </span> ; <span class="author-name" > Burgalossi, Andrea ✉ </span> <span class="author-type"> </span> </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34602262" mtid="34602262" target="_blank">Sensory and behavioral modulation of thalamic head-direction cells</a></div> <div class="pub-info"> <span class="journal-title">NATURE NEUROSCIENCE</span> <span class="journal-volume"></span> <span class="page"> , 22 p. </span> <span class="year">(2024)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41593-023-01506-1" target="_blank" href="https://doi.org/10.1038/s41593-023-01506-1"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001136721300004" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001136721300004"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85181442219" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85181442219"> Scopus </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:34602262 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
<div class="authors">
<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png">
<div class="autype autype0"> <span class="author-name" >Blanco-Hernandez Eduardo
</span>
;
<span class="author-name" >Balsamo Giuseppe
</span>
;
<span class="author-name" >Preston-Ferrer Patricia ✉
</span>
;
<span class="author-name" >Burgalossi Andrea ✉
</span>
</div>
</div>
<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34602262" target="_blank">Sensory and behavioral modulation of thalamic head-direction cells</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-6256">1097-6256</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1546-1726">1546-1726</a>)</span>:
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22 p.
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<span class="language" xmlns="http://www.w3.org/1999/html">Nyelv:
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<div class="lastModified">Utolsó módosítás: 2024.02.16. 20:48 Szuper Admin (admin)
</div>
<pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 28 February 2024; CODEN: NANEF</pre>
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Neurovascular coupling (NVC) is important for brain function and its dysfunction underlies many neuropathologies. Although cell-type specificity has been implicated in NVC, how active neural information is conveyed to the targeted arterioles in the brain remains poorly understood. Here, using two-photon focal optogenetics in the mouse cerebral cortex, we demonstrate that single glutamatergic axons dilate their innervating arterioles via synaptic-like transmission between neural-arteriolar smooth muscle cell junctions (NsMJs). The presynaptic parental-daughter bouton makes dual innervations on postsynaptic dendrites and on arteriolar smooth muscle cells (aSMCs), which express many types of neuromediator receptors, including a low level of glutamate NMDA receptor subunit 1 (Grin1). Disruption of NsMJ transmission by aSMC-specific knockout of GluN1 diminished optogenetic and whisker stimulation-caused functional hyperemia. Notably, the absence of GluN1 subunit in aSMCs reduced brain atrophy following cerebral ischemia by preventing Ca2+ overload in aSMCs during arteriolar constriction caused by the ischemia-induced spreading depolarization. Our findings reveal that NsMJ transmission drives NVC and open up a new avenue for studying stroke.In the CNS, glutamatergic neurons directly control functional hyperemia via synaptic-like transmission onto arteriolar smooth muscle cells. Inhibiting this process reduces brain atrophy following cerebral ischemia.
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<div class="JournalArticle Publication short-list"> <div class="authors"> <span class="author-name" > Zhang, Dongdong </span> <span class="author-type"> </span> ; <span class="author-name" > Ruan, Jiayu </span> <span class="author-type"> </span> ; <span class="author-name" > Peng, Shiyu </span> <span class="author-type"> </span> ; <span class="author-name" > Li, Jinze </span> <span class="author-type"> </span> ; <span class="author-name" > Hu, Xu </span> <span class="author-type"> </span> ; <span class="author-name" > Zhang, Yiyi </span> <span class="author-type"> </span> ; <span class="author-name" > Zhang, Tianrui </span> <span class="author-type"> </span> ; <span class="author-name" > Ge, Yaping </span> <span class="author-type"> </span> ; <span class="author-name" > Zhu, Zhu </span> <span class="author-type"> </span> ; <span class="author-name" > Xiao, Xian </span> <span class="author-type"> </span> et al. </div ><div class="title"><a href="/gui2/?mode=browse¶ms=publication;34586022" mtid="34586022" target="_blank">Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling</a></div> <div class="pub-info"> <span class="journal-title">NATURE NEUROSCIENCE</span> <span class="journal-volume"></span> <span class="page"> , 41 p. </span> <span class="year">(2024)</span> </div> <div class="pub-end"><div class="identifier-list"> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41593-023-01515-0" target="_blank" href="https://doi.org/10.1038/s41593-023-01515-0"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001135025000002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001135025000002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="85181211921" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85181211921"> Scopus </a> </span> </span> </div> <div class="short-pub-prop-list"> <span class="short-pub-mtid"> Közlemény:34586022 </span> <span class="status-holder"><span class="status-data status-VALIDATED"> Egyeztetett </span></span> <span class="pub-core"> Idéző </span> <span class="pub-type">Folyóiratcikk (Szakcikk ) </span> <!-- && !record.category.scientific --> <span class="pub-category">Tudományos</span> </div> </div> </div><div class="JournalArticle Publication long-list">
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<div class="autype autype0"> <span class="author-name" >Zhang Dongdong
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<span class="author-name" >Ruan Jiayu
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<span class="author-name" >Li Jinze
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<span class="author-name" >Hu Xu
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<span class="author-name" >Zhu Yunxu
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<span class="author-name" >Li Xuzhao
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<span class="author-name" >Li Tingbo
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<span class="author-name" >Zhou Lili
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;
<span class="author-name" >Gao Qingzhu
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;
<span class="author-name" >Zheng Guoxiao
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;
<span class="author-name" >Zhao Bingrui
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;
<span class="author-name" >Li Xiangqing
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;
<span class="author-name" >Zhu Yanming
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;
<span class="author-name" >Wu Jinsong
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;
<span class="author-name" >Li Wensheng
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;
<span class="author-name" >Zhao Jingwei
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;
<span class="author-name" >Ge Woo-Ping
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;
<span class="author-name" >Xu Tian
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;
<span class="author-name" >Jia Jie-Min ✉
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<div class="title"><a href="/gui2/?mode=browse¶ms=publication;34586022" target="_blank">Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span>
<span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-6256">1097-6256</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1546-1726">1546-1726</a>)</span>:
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<span class="page">
41 p.
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Idézett közlemények száma: 1
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<div class="mtid"><span class="long-pub-mtid">Közlemény: 34586022</span>
| <span class="status-data status-VALIDATED"> Egyeztetett
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Idéző
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<div class="lastModified">Utolsó módosítás: 2024.02.15. 01:10 Szuper Admin (admin)
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