TY  - JOUR
AU  - Sainburg, T.
AU  - McPherson, T.S.
AU  - Arneodo, E.M.
AU  - Rudraraju, S.
AU  - Turvey, M.
AU  - Theilman, B.H.
AU  - Tostado, Marcos P.
AU  - Thielk, M.
AU  - Gentner, T.Q.
TI  - Expectation-driven sensory adaptations support enhanced acuity during categorical perception
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
VL  - 28
PY  - 2025
SP  - 861
EP  - 872
PG  - 12
SN  - 1097-6256
DO  - 10.1038/s41593-025-01899-1
UR  - https://m2.mtmt.hu/api/publication/36105587
ID  - 36105587
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Mohar, Boaz
AU  - Michel, Gabriela
AU  - Wang, Yi-Zhi
AU  - Hernandez, Veronica
AU  - Grimm, Jonathan B.
AU  - Park, Jin-Yong
AU  - Patel, Ronak
AU  - Clarke, Morgan
AU  - Brown, Timothy A.
AU  - Bergmann, Cornelius
AU  - Gebis, Kamil K.
AU  - Wilen, Anika P.
AU  - Liu, Bian
AU  - Johnson, Richard
AU  - Graves, Austin
AU  - Tchumatchenko, Tatjana
AU  - Savas, Jeffrey N.
AU  - Fornasiero, Eugenio F.
AU  - Huganir, Richard L.
AU  - Tillberg, Paul W.
AU  - Lavis, Luke D.
AU  - Svoboda, Karel
AU  - Spruston, Nelson
TI  - DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
PY  - 2025
PG  - 37
SN  - 1097-6256
DO  - 10.1038/s41593-025-01923-4
UR  - https://m2.mtmt.hu/api/publication/36096032
ID  - 36096032
N1  - Funding Agency and Grant Number: Howard Hughes Medical Institute (HHMI); Howard Hughes Medical Institute [SFB1286]; PGA Foundation [S10 OD032464]; National Institutes of Health [945700]; European Research Council
            Funding text: We thank C.G. for the generation of the GluA2-HT and the MeCP2-HT lines; B. Foster, M. Copeland, A. Hu and S. Michael for histology; M. DeSantis and D. Alcor for help with imaging; G. Harris, M. Rose and S. Lindo for help with animal husbandry and surgery; A. Gutu, K. Ritola and H. A. Yi for viral reagents; A. Tkachuk, A. Osowski and K. Holland for help with JF-HTL dyes; E. Schreiter for the GFP-HT virus; J. Liu for the MeCP2-HT mouse; and S. Grant for the PSD-95-HT mouse. We thank A. Singh for assistance with dye ligand clearance imaging. We thank the Proteomics Core at Northwestern University for their help with the MS measurements. This research was funded by the Howard Hughes Medical Institute (to B.M., G.M., V.H., J.B.G., J.Y.P., R.P., M.C., T.A.B., P.W.T., L.D.L., K.S. and N.S.), the PGA Foundation (to K.S.), CZI Collaborative Pairs Pilot Project Awards (cycle 2; phase 1; to E.F.F.), SFB1286 (to E.F.F.), the National Institutes of Health Grant S10 OD032464 (to J.N.S.) and European Research Council grant MolDynForSyn number 945700 Horizon 2020 (to T.T.).
AB  - Synaptic plasticity alters neuronal connections in response to experience, which is thought to underlie learning and memory. However, the loci of learning-related synaptic plasticity, and the degree to which plasticity is localized or distributed, remain largely unknown. Here we describe a new method, DELTA, for mapping brain-wide changes in synaptic protein turnover with single-synapse resolution, based on Janelia Fluor dyes and HaloTag knock-in mice. During associative learning, the turnover of the ionotropic glutamate receptor subunit GluA2, an indicator of synaptic plasticity, was enhanced in several brain regions, most markedly hippocampal area CA1. More broadly distributed increases in the turnover of synaptic proteins were observed in response to environmental enrichment. In CA1, GluA2 stability was regulated in an input-specific manner, with more turnover in layers containing input from CA3 compared to entorhinal cortex. DELTA will facilitate exploration of the molecular and circuit basis of learning and memory and other forms of plasticity at scales ranging from single synapses to the entire brain.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Arkhipov, A.
AU  - da, Costa N.
AU  - de, Vries S.
AU  - Bakken, T.
AU  - Bennett, C.
AU  - Bernard, A.
AU  - Berg, J.
AU  - Buice, M.
AU  - Collman, F.
AU  - Daigle, T.
AU  - Garrett, M.
AU  - Gouwens, N.
AU  - Groblewski, P.A.
AU  - Harris, J.
AU  - Hawrylycz, M.
AU  - Hodge, R.
AU  - Jarsky, T.
AU  - Kalmbach, B.
AU  - Lecoq, J.
AU  - Lee, B.
AU  - Lein, E.
AU  - Levi, B.
AU  - Mihalas, S.
AU  - Ng, L.
AU  - Olsen, S.
AU  - Reid, C.
AU  - Siegle, J.H.
AU  - Sorensen, S.
AU  - Tasic, B.
AU  - Thompson, C.
AU  - Ting, J.T.
AU  - van, Velthoven C.
AU  - Yao, S.
AU  - Yao, Z.
AU  - Koch, C.
AU  - Zeng, H.
TI  - Integrating multimodal data to understand cortical circuit architecture and function
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
PY  - 2025
SN  - 1097-6256
DO  - 10.1038/s41593-025-01904-7
UR  - https://m2.mtmt.hu/api/publication/36084590
ID  - 36084590
N1  - Allen Institute, Seattle, WA, United States            
            The Kavli Foundation, Los Angeles, CA, United States            
            Cure Alzheimer’s Fund, Wellesley Hills, MA, United States            
            Export Date: 10 April 2025; Cited By: 0; Correspondence Address: A. Arkhipov; Allen Institute, Seattle, United States; email: antona@alleninstitute.org; N. da Costa; Allen Institute, Seattle, United States; email: nunod@alleninstitute.org; S. de Vries; Allen Institute, Seattle, United States; email: saskiad@alleninstitute.org; CODEN: NANEF
AB  - In recent years there has been a tremendous growth in new technologies that allow large-scale investigation of different characteristics of the nervous system at an unprecedented level of detail. There is a growing trend to use combinations of these new techniques to determine direct links between different modalities. In this Perspective, we focus on the mouse visual cortex, as this is one of the model systems in which much progress has been made in the integration of multimodal data to advance understanding. We review several approaches that allow integration of data regarding various properties of cortical cell types, connectivity at the level of brain areas, cell types and individual cells, and functional neural activity in vivo. The increasingly crucial contributions of computation and theory in analyzing and systematically modeling data are also highlighted. Together with open sharing of data, tools and models, integrative approaches are essential tools in modern neuroscience for improving our understanding of the brain architecture, mechanisms and function. © Springer Nature America, Inc. 2025.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bernier, Louis-Philippe
AU  - Hefendehl, Jasmin K.
AU  - Scott, R. Wilder
AU  - Tung, Lin Wei
AU  - Lewis, Coral-Ann
AU  - Soliman, Hesham
AU  - Simm, Stefan
AU  - Dissing-Olesen, Lasse
AU  - Hofmann, Jan
AU  - Guo, David
AU  - Demeglio, Murphy
AU  - Rossi, Fabio M.
AU  - Underhill, T. Michael
AU  - Macvicar, Brian A.
TI  - Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
PY  - 2025
PG  - 47
SN  - 1097-6256
DO  - 10.1038/s41593-025-01872-y
UR  - https://m2.mtmt.hu/api/publication/36014730
ID  - 36014730
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Abellanas, Miguel A.
AU  - Purnapatre, Maitreyee
AU  - Burgaletto, Chiara
AU  - Schwartz, Michal
TI  - Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer's disease
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
PY  - 2025
PG  - 10
SN  - 1097-6256
DO  - 10.1038/s41593-024-01847-5
UR  - https://m2.mtmt.hu/api/publication/35984807
ID  - 35984807
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Yano, Sarasa
AU  - Asami, Natsu
AU  - Kishi, Yusuke
AU  - Takeda, Ikuko
AU  - Kubotani, Hikari
AU  - Hattori, Yuki
AU  - Kitazawa, Ayako
AU  - Hayashi, Kanehiro
AU  - Kubo, Ken-ichiro
AU  - Saeki, Mai
AU  - Maeda, Chihiro
AU  - Hiraki, Chihiro
AU  - Teruya, Rin-ichiro
AU  - Taketomi, Takumi
AU  - Akiyama, Kaito
AU  - Okajima-Takahashi, Tomomi
AU  - Sato, Ban
AU  - Wake, Hiroaki
AU  - Gotoh, Yukiko
AU  - Nakajima, Kazunori
AU  - Ichinohe, Takeshi
AU  - Nagata, Takeshi
AU  - Chiba, Tomoki
AU  - Tsuruta, Fuminori
TI  - Propagation of neuronal micronuclei regulates microglial characteristics
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
PY  - 2025
PG  - 32
SN  - 1097-6256
DO  - 10.1038/s41593-024-01863-5
UR  - https://m2.mtmt.hu/api/publication/35984803
ID  - 35984803
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Izzy, Saef
AU  - Yahya, Taha
AU  - Albastaki, Omar
AU  - Abou-El-Hassan, Hadi
AU  - Aronchik, Michael
AU  - Cao, Tian
AU  - De Oliveira, Marilia Garcia
AU  - Lu, Kuan-Jung
AU  - Moreira, Thais G.
AU  - da Silva, Patrick
AU  - Boucher, Masen L.
AU  - Beauchamp, Leah C.
AU  - S. LeServe, Danielle
AU  - Brandao, Wesley Nogueira
AU  - Carolina Durao, Ana
AU  - Lanser, Toby
AU  - Montini, Federico
AU  - Lee, Joon-Hyuk
AU  - Bernstock, Joshua D.
AU  - Kaul, Megha
AU  - Pasquarelli-do-Nascimento, Gabriel
AU  - Chopra, Kusha
AU  - Krishnan, Rajesh
AU  - Mannix, Rebekah
AU  - Rezende, Rafael M.
AU  - Quintana, Francisco J.
AU  - Butovsky, Oleg
AU  - Weiner, Howard L.
TI  - Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent T<sub>reg</sub>-microglia crosstalk
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
PY  - 2025
PG  - 42
SN  - 1097-6256
DO  - 10.1038/s41593-025-01877-7
UR  - https://m2.mtmt.hu/api/publication/35960339
ID  - 35960339
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - DeSpenza Jr, Tyrone
AU  - Kiziltug, Emre
AU  - Allington, Garrett
AU  - Barson, Daniel G.
AU  - Mcgee, Stephen
AU  - O'Connor, David
AU  - Robert, Stephanie M.
AU  - Mekbib, Kedous Y.
AU  - Nanda, Pranav
AU  - Greenberg, Ana B. W.
AU  - Singh, Amrita
AU  - Duy, Phan Q.
AU  - Mandino, Francesca
AU  - Zhao, Shujuan
AU  - Lynn, Anna
AU  - Reeves, Benjamin C.
AU  - Marlier, Arnaud
AU  - Getz, Stephanie A.
AU  - Nelson-Williams, Carol
AU  - Shimelis, Hermela
AU  - Walsh, Lauren K.
AU  - Zhang, Junhui
AU  - Wang, Wei
AU  - Prina, Mackenzi L.
AU  - Ouyang, Annaliese
AU  - Abdulkareem, Asan F.
AU  - Smith, Hannah
AU  - Shohfi, John
AU  - Mehta, Neel H.
AU  - Dennis, Evan
AU  - Reduron, Laetitia R.
AU  - Hong, Jennifer
AU  - Butler, William
AU  - Carter, Bob S.
AU  - Deniz, Engin
AU  - Lake, Evelyn M. R.
AU  - Constable, R. Todd
AU  - Sahin, Mustafa
AU  - Srivastava, Siddharth
AU  - Winden, Kellen
AU  - Hoffman, Ellen J.
AU  - Carlson, Marina
AU  - Gunel, Murat
AU  - Lifton, Richard P.
AU  - Alper, Seth L.
AU  - Jin, Sheng Chih
AU  - Crair, Michael C.
AU  - Moreno-De-Luca, Andres
AU  - Luikart, Bryan W.
AU  - Kahle, Kristopher T.
TI  - PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
PY  - 2025
PG  - 41
SN  - 1097-6256
DO  - 10.1038/s41593-024-01865-3
UR  - https://m2.mtmt.hu/api/publication/35874251
ID  - 35874251
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Del Rosario, Joseph
AU  - Coletta, Stefano
AU  - Kim, Soon Ho
AU  - Mobille, Zach
AU  - Peelman, Kayla
AU  - Williams, Brice
AU  - Otsuki, Alan J.
AU  - Valerio, Alejandra Del Castillo
AU  - Worden, Kendell
AU  - Blanpain, Lou T.
AU  - Lovell, Lyndah
AU  - Choi, Hannah
AU  - Haider, Bilal
TI  - Lateral inhibition in V1 controls neural and perceptual contrast sensitivity
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
PY  - 2025
PG  - 29
SN  - 1097-6256
DO  - 10.1038/s41593-025-01888-4
UR  - https://m2.mtmt.hu/api/publication/35857854
ID  - 35857854
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kedia, Shreeya
AU  - Simons, Mikael
TI  - Oligodendrocytes in Alzheimer's disease pathophysiology
JF  - NATURE NEUROSCIENCE
J2  - NAT NEUROSCI
PY  - 2025
PG  - 11
SN  - 1097-6256
DO  - 10.1038/s41593-025-01873-x
UR  - https://m2.mtmt.hu/api/publication/35842659
ID  - 35842659
LA  - English
DB  - MTMT
ER  -