@article{MTMT:36105587, title = {Expectation-driven sensory adaptations support enhanced acuity during categorical perception}, url = {https://m2.mtmt.hu/api/publication/36105587}, author = {Sainburg, T. and McPherson, T.S. and Arneodo, E.M. and Rudraraju, S. and Turvey, M. and Theilman, B.H. and Tostado, Marcos P. and Thielk, M. and Gentner, T.Q.}, doi = {10.1038/s41593-025-01899-1}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, volume = {28}, unique-id = {36105587}, issn = {1097-6256}, year = {2025}, eissn = {1546-1726}, pages = {861-872} } @article{MTMT:36096032, title = {DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning}, url = {https://m2.mtmt.hu/api/publication/36096032}, author = {Mohar, Boaz and Michel, Gabriela and Wang, Yi-Zhi and Hernandez, Veronica and Grimm, Jonathan B. and Park, Jin-Yong and Patel, Ronak and Clarke, Morgan and Brown, Timothy A. and Bergmann, Cornelius and Gebis, Kamil K. and Wilen, Anika P. and Liu, Bian and Johnson, Richard and Graves, Austin and Tchumatchenko, Tatjana and Savas, Jeffrey N. and Fornasiero, Eugenio F. and Huganir, Richard L. and Tillberg, Paul W. and Lavis, Luke D. and Svoboda, Karel and Spruston, Nelson}, doi = {10.1038/s41593-025-01923-4}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, unique-id = {36096032}, issn = {1097-6256}, abstract = {Synaptic plasticity alters neuronal connections in response to experience, which is thought to underlie learning and memory. However, the loci of learning-related synaptic plasticity, and the degree to which plasticity is localized or distributed, remain largely unknown. Here we describe a new method, DELTA, for mapping brain-wide changes in synaptic protein turnover with single-synapse resolution, based on Janelia Fluor dyes and HaloTag knock-in mice. During associative learning, the turnover of the ionotropic glutamate receptor subunit GluA2, an indicator of synaptic plasticity, was enhanced in several brain regions, most markedly hippocampal area CA1. More broadly distributed increases in the turnover of synaptic proteins were observed in response to environmental enrichment. In CA1, GluA2 stability was regulated in an input-specific manner, with more turnover in layers containing input from CA3 compared to entorhinal cortex. DELTA will facilitate exploration of the molecular and circuit basis of learning and memory and other forms of plasticity at scales ranging from single synapses to the entire brain.}, keywords = {CELL; MEMORY; DEGRADATION; AMPA RECEPTORS; TRAFFICKING; GLUTAMATE RECEPTORS; GENERAL-METHOD; RETT-SYNDROME; ACTIVITY-DEPENDENT REGULATION}, year = {2025}, eissn = {1546-1726} } @article{MTMT:36084590, title = {Integrating multimodal data to understand cortical circuit architecture and function}, url = {https://m2.mtmt.hu/api/publication/36084590}, author = {Arkhipov, A. and da, Costa N. and de, Vries S. and Bakken, T. and Bennett, C. and Bernard, A. and Berg, J. and Buice, M. and Collman, F. and Daigle, T. and Garrett, M. and Gouwens, N. and Groblewski, P.A. and Harris, J. and Hawrylycz, M. and Hodge, R. and Jarsky, T. and Kalmbach, B. and Lecoq, J. and Lee, B. and Lein, E. and Levi, B. and Mihalas, S. and Ng, L. and Olsen, S. and Reid, C. and Siegle, J.H. and Sorensen, S. and Tasic, B. and Thompson, C. and Ting, J.T. and van, Velthoven C. and Yao, S. and Yao, Z. and Koch, C. and Zeng, H.}, doi = {10.1038/s41593-025-01904-7}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, unique-id = {36084590}, issn = {1097-6256}, abstract = {In recent years there has been a tremendous growth in new technologies that allow large-scale investigation of different characteristics of the nervous system at an unprecedented level of detail. There is a growing trend to use combinations of these new techniques to determine direct links between different modalities. In this Perspective, we focus on the mouse visual cortex, as this is one of the model systems in which much progress has been made in the integration of multimodal data to advance understanding. We review several approaches that allow integration of data regarding various properties of cortical cell types, connectivity at the level of brain areas, cell types and individual cells, and functional neural activity in vivo. The increasingly crucial contributions of computation and theory in analyzing and systematically modeling data are also highlighted. Together with open sharing of data, tools and models, integrative approaches are essential tools in modern neuroscience for improving our understanding of the brain architecture, mechanisms and function. © Springer Nature America, Inc. 2025.}, keywords = {ARTICLE; MOUSE; human; nonhuman; visual cortex; Nervous System}, year = {2025}, eissn = {1546-1726} } @article{MTMT:36014730, title = {Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke}, url = {https://m2.mtmt.hu/api/publication/36014730}, author = {Bernier, Louis-Philippe and Hefendehl, Jasmin K. and Scott, R. Wilder and Tung, Lin Wei and Lewis, Coral-Ann and Soliman, Hesham and Simm, Stefan and Dissing-Olesen, Lasse and Hofmann, Jan and Guo, David and Demeglio, Murphy and Rossi, Fabio M. and Underhill, T. Michael and Macvicar, Brian A.}, doi = {10.1038/s41593-025-01872-y}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, unique-id = {36014730}, issn = {1097-6256}, year = {2025}, eissn = {1546-1726}, orcid-numbers = {Bernier, Louis-Philippe/0000-0001-5063-2338} } @article{MTMT:35984807, title = {Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer's disease}, url = {https://m2.mtmt.hu/api/publication/35984807}, author = {Abellanas, Miguel A. and Purnapatre, Maitreyee and Burgaletto, Chiara and Schwartz, Michal}, doi = {10.1038/s41593-024-01847-5}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, unique-id = {35984807}, issn = {1097-6256}, year = {2025}, eissn = {1546-1726}, orcid-numbers = {Burgaletto, Chiara/0000-0002-5517-8223} } @article{MTMT:35984803, title = {Propagation of neuronal micronuclei regulates microglial characteristics}, url = {https://m2.mtmt.hu/api/publication/35984803}, author = {Yano, Sarasa and Asami, Natsu and Kishi, Yusuke and Takeda, Ikuko and Kubotani, Hikari and Hattori, Yuki and Kitazawa, Ayako and Hayashi, Kanehiro and Kubo, Ken-ichiro and Saeki, Mai and Maeda, Chihiro and Hiraki, Chihiro and Teruya, Rin-ichiro and Taketomi, Takumi and Akiyama, Kaito and Okajima-Takahashi, Tomomi and Sato, Ban and Wake, Hiroaki and Gotoh, Yukiko and Nakajima, Kazunori and Ichinohe, Takeshi and Nagata, Takeshi and Chiba, Tomoki and Tsuruta, Fuminori}, doi = {10.1038/s41593-024-01863-5}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, unique-id = {35984803}, issn = {1097-6256}, year = {2025}, eissn = {1546-1726}, orcid-numbers = {Kishi, Yusuke/0000-0003-2846-5400; Kubo, Ken-ichiro/0000-0003-4023-5069} } @article{MTMT:35960339, title = {Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg-microglia crosstalk}, url = {https://m2.mtmt.hu/api/publication/35960339}, author = {Izzy, Saef and Yahya, Taha and Albastaki, Omar and Abou-El-Hassan, Hadi and Aronchik, Michael and Cao, Tian and De Oliveira, Marilia Garcia and Lu, Kuan-Jung and Moreira, Thais G. and da Silva, Patrick and Boucher, Masen L. and Beauchamp, Leah C. and S. LeServe, Danielle and Brandao, Wesley Nogueira and Carolina Durao, Ana and Lanser, Toby and Montini, Federico and Lee, Joon-Hyuk and Bernstock, Joshua D. and Kaul, Megha and Pasquarelli-do-Nascimento, Gabriel and Chopra, Kusha and Krishnan, Rajesh and Mannix, Rebekah and Rezende, Rafael M. and Quintana, Francisco J. and Butovsky, Oleg and Weiner, Howard L.}, doi = {10.1038/s41593-025-01877-7}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, unique-id = {35960339}, issn = {1097-6256}, year = {2025}, eissn = {1546-1726}, orcid-numbers = {Abou-El-Hassan, Hadi/0000-0002-2765-291X} } @article{MTMT:35874251, title = {PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors}, url = {https://m2.mtmt.hu/api/publication/35874251}, author = {DeSpenza Jr, Tyrone and Kiziltug, Emre and Allington, Garrett and Barson, Daniel G. and Mcgee, Stephen and O'Connor, David and Robert, Stephanie M. and Mekbib, Kedous Y. and Nanda, Pranav and Greenberg, Ana B. W. and Singh, Amrita and Duy, Phan Q. and Mandino, Francesca and Zhao, Shujuan and Lynn, Anna and Reeves, Benjamin C. and Marlier, Arnaud and Getz, Stephanie A. and Nelson-Williams, Carol and Shimelis, Hermela and Walsh, Lauren K. and Zhang, Junhui and Wang, Wei and Prina, Mackenzi L. and Ouyang, Annaliese and Abdulkareem, Asan F. and Smith, Hannah and Shohfi, John and Mehta, Neel H. and Dennis, Evan and Reduron, Laetitia R. and Hong, Jennifer and Butler, William and Carter, Bob S. and Deniz, Engin and Lake, Evelyn M. R. and Constable, R. Todd and Sahin, Mustafa and Srivastava, Siddharth and Winden, Kellen and Hoffman, Ellen J. and Carlson, Marina and Gunel, Murat and Lifton, Richard P. and Alper, Seth L. and Jin, Sheng Chih and Crair, Michael C. and Moreno-De-Luca, Andres and Luikart, Bryan W. and Kahle, Kristopher T.}, doi = {10.1038/s41593-024-01865-3}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, unique-id = {35874251}, issn = {1097-6256}, year = {2025}, eissn = {1546-1726}, orcid-numbers = {O'Connor, David/0000-0002-8885-518X} } @article{MTMT:35857854, title = {Lateral inhibition in V1 controls neural and perceptual contrast sensitivity}, url = {https://m2.mtmt.hu/api/publication/35857854}, author = {Del Rosario, Joseph and Coletta, Stefano and Kim, Soon Ho and Mobille, Zach and Peelman, Kayla and Williams, Brice and Otsuki, Alan J. and Valerio, Alejandra Del Castillo and Worden, Kendell and Blanpain, Lou T. and Lovell, Lyndah and Choi, Hannah and Haider, Bilal}, doi = {10.1038/s41593-025-01888-4}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, unique-id = {35857854}, issn = {1097-6256}, year = {2025}, eissn = {1546-1726} } @article{MTMT:35842659, title = {Oligodendrocytes in Alzheimer's disease pathophysiology}, url = {https://m2.mtmt.hu/api/publication/35842659}, author = {Kedia, Shreeya and Simons, Mikael}, doi = {10.1038/s41593-025-01873-x}, journal-iso = {NAT NEUROSCI}, journal = {NATURE NEUROSCIENCE}, unique-id = {35842659}, issn = {1097-6256}, year = {2025}, eissn = {1546-1726} }