https://m2.mtmt.hu/ hun 2026-07-19 23:38 false true 366 3656 3656 3300 10 1 10 DESC publishedYear false DESC issue false JournalArticle 37058755 VALIDATED true 0 false 2026-07-09T09:02:14.726+0000 2026-06-13T13:59:19.412+0000 2026-04-02T09:21:18.765+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-07-09T08:58:43.566+0000 2026-05-20T20:32:14.025+0000 true 521 Szuper Admin /api/admin/521 Admin true false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Lee, Yong-Joon Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 394 1365 1375 1365 11 2026 Background Despite guideline recommendations, evidence from randomized trials evaluating the appropriate low-density lipoprotein (LDL) cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease remains limited.Methods In this open-label superiority trial conducted in South Korea, we randomly assigned patients with atherosclerotic cardiovascular disease in a 1:1 ratio to a target LDL cholesterol level of less than 55 mg per deciliter (1.4 mmol per liter) (intensive-targeting group) or less than 70 mg per deciliter (1.8 mmol per liter) (conventional-targeting group). The primary end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, any revascularization, or hospitalization for unstable angina at 3 years. Safety was also assessed.Results Of 3048 patients who underwent randomization, 1526 were assigned to the intensive-targeting group and 1522 to the conventional-targeting group. The median follow-up was 3.0 years. The median LDL cholesterol level during the trial was 56 mg per deciliter (1.4 mmol per liter) in the intensive-targeting group and 66 mg per deciliter (1.7 mmol per liter) in the conventional-targeting group. A primary end-point event occurred in 100 patients (Kaplan-Meier estimate of cumulative incidence, 6.6%) in the intensive-targeting group and in 147 patients (Kaplan-Meier estimate of cumulative incidence, 9.7%) in the conventional-targeting group (hazard ratio, 0.67; 95% confidence interval, 0.52 to 0.86; P=0.002). The incidence of prespecified safety end points was similar in the two trial groups, except for a lower incidence of creatinine elevation in the intensive-targeting group.Conclusions Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level of less than 55 mg per deciliter resulted in a lower risk of cardiovascular events at 3 years than targeting a level of less than 70 mg per deciliter. (Funded by the Cardiovascular Research Center and Yuhan; Ez-PAVE ClinicalTrials.gov number, NCT04626973.) Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter. 2026 true true true false false NONE 2026-07-09 false 0 0 0 0 0 0 0 0 0 0 0 0 6 6 D1 false false false false 2026-06-12T13:59:19.283+0000 14 84 0 25 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 136867954 /api/authorship/136867954 1 0.04 true false false Lee Yong-Joon true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867955 /api/authorship/136867955 2 0.04 false false false Lee Seung-Jun true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867956 /api/authorship/136867956 3 0.04 false false false Kim Jin Won true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867957 /api/authorship/136867957 4 0.04 false false false Lee Sang-Hyup true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867958 /api/authorship/136867958 5 0.04 false false false Kim Gwang-Sil true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867959 /api/authorship/136867959 6 0.04 false false false Park Jae Hyoung true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867960 /api/authorship/136867960 7 0.04 false false false Cho Jin-Man true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867961 /api/authorship/136867961 8 0.04 false false false Kang Woong Chol true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867962 /api/authorship/136867962 9 0.04 false false false Yoon Hyuck-Jun true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867963 /api/authorship/136867963 10 0.04 false false false Kim Won Ho true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867964 /api/authorship/136867964 11 0.04 false false false Lee Seung-Jin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867965 /api/authorship/136867965 12 0.04 false false false Lee Jin Bae true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867966 /api/authorship/136867966 13 0.04 false false false Jang Ji-Yong true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867967 /api/authorship/136867967 14 0.04 false false false Shin Sanghoon true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867968 /api/authorship/136867968 15 0.04 false false false Park Ik Hyun true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867969 /api/authorship/136867969 16 0.04 false false false Kwon Sung Uk true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867970 /api/authorship/136867970 17 0.04 false false false Kim Sunwon true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867971 /api/authorship/136867971 18 0.04 false false false Hong Sung-Jin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867972 /api/authorship/136867972 19 0.04 false false false Ahn Chul-Min true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867973 /api/authorship/136867973 20 0.04 false false false Kim Jung-Sun true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136867974 /api/authorship/136867974 21 0.04 false false 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FROM_LAST_YEAR true true /api/publication/37058755 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Lee Yong-Joon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lee Seung-Jun </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kim Jin Won </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lee Sang-Hyup </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kim Gwang-Sil </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Park Jae Hyoung </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cho Jin-Man </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kang Woong Chol </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yoon Hyuck-Jun </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kim Won Ho </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lee Seung-Jin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lee Jin Bae </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jang Ji-Yong </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shin Sanghoon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Park Ik Hyun </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kwon Sung Uk </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kim Sunwon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hong Sung-Jin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ahn Chul-Min </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kim Jung-Sun </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ko Young-Guk </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Choi Donghoon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hong Myeong-Ki </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jang Yangsoo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kim Byeong-Keuk ✉ </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">Ez-PAVE Investigators</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37058755" target="_blank">Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">394</span> <span class="page"> pp 1365-1375 </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa2600283" target="_blank" href="https://doi.org/10.1056/NEJMoa2600283"> DOI </a> </span> 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;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ravelo-Hernandez Jorge </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Santiago Mittermayer B. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zazueta Montiel Beatriz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Botha Stella </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Leszczynski Piotr </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >de Souza Viviane Angelina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sicsik Sandra A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bellatin Luis </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Naidoo Asokan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Amoura Zahir </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >D'Dgostino Maria Antonietta </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kumar Sunil </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Workeneh Biruh </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rae Julie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mao Huiyan A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Erblang Felix </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Meier Oliver </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maller Justine C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Askanase Anca D. </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">ALLEGORY Trial Investigators</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37071448" target="_blank">Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span 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