TY  - JOUR
AU  - Lee, Yong-Joon
AU  - Lee, Seung-Jun
AU  - Kim, Jin Won
AU  - Lee, Sang-Hyup
AU  - Kim, Gwang-Sil
AU  - Park, Jae Hyoung
AU  - Cho, Jin-Man
AU  - Kang, Woong Chol
AU  - Yoon, Hyuck-Jun
AU  - Kim, Won Ho
AU  - Lee, Seung-Jin
AU  - Lee, Jin Bae
AU  - Jang, Ji-Yong
AU  - Shin, Sanghoon
AU  - Park, Ik Hyun
AU  - Kwon, Sung Uk
AU  - Kim, Sunwon
AU  - Hong, Sung-Jin
AU  - Ahn, Chul-Min
AU  - Kim, Jung-Sun
AU  - Ko, Young-Guk
AU  - Choi, Donghoon
AU  - Hong, Myeong-Ki
AU  - Jang, Yangsoo
AU  - Kim, Byeong-Keuk
TI  - Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
VL  - 394
PY  - 2026
SP  - 1365
EP  - 1375
PG  - 11
SN  - 0028-4793
DO  - 10.1056/NEJMoa2600283
UR  - https://m2.mtmt.hu/api/publication/37058755
ID  - 37058755
AB  - Background Despite guideline recommendations, evidence from randomized trials evaluating the appropriate low-density lipoprotein (LDL) cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease remains limited.Methods In this open-label superiority trial conducted in South Korea, we randomly assigned patients with atherosclerotic cardiovascular disease in a 1:1 ratio to a target LDL cholesterol level of less than 55 mg per deciliter (1.4 mmol per liter) (intensive-targeting group) or less than 70 mg per deciliter (1.8 mmol per liter) (conventional-targeting group). The primary end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, any revascularization, or hospitalization for unstable angina at 3 years. Safety was also assessed.Results Of 3048 patients who underwent randomization, 1526 were assigned to the intensive-targeting group and 1522 to the conventional-targeting group. The median follow-up was 3.0 years. The median LDL cholesterol level during the trial was 56 mg per deciliter (1.4 mmol per liter) in the intensive-targeting group and 66 mg per deciliter (1.7 mmol per liter) in the conventional-targeting group. A primary end-point event occurred in 100 patients (Kaplan-Meier estimate of cumulative incidence, 6.6%) in the intensive-targeting group and in 147 patients (Kaplan-Meier estimate of cumulative incidence, 9.7%) in the conventional-targeting group (hazard ratio, 0.67; 95% confidence interval, 0.52 to 0.86; P=0.002). The incidence of prespecified safety end points was similar in the two trial groups, except for a lower incidence of creatinine elevation in the intensive-targeting group.Conclusions Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level of less than 55 mg per deciliter resulted in a lower risk of cardiovascular events at 3 years than targeting a level of less than 70 mg per deciliter. (Funded by the Cardiovascular Research Center and Yuhan; Ez-PAVE ClinicalTrials.gov number, NCT04626973.) Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Furie, Richard A.
AU  - Dall'era, Maria
AU  - Vital, Edward M.
AU  - Garg, Jay P.
AU  - Irazoque, Palazuelos Fedra
AU  - Zuta, Santillan Adolfina E.
AU  - Ravelo-Hernandez, Jorge
AU  - Santiago, Mittermayer B.
AU  - Zazueta, Montiel Beatriz
AU  - Botha, Stella
AU  - Leszczynski, Piotr
AU  - de, Souza Viviane Angelina
AU  - Sicsik, Sandra A.
AU  - Bellatin, Luis
AU  - Naidoo, Asokan
AU  - Amoura, Zahir
AU  - D'Dgostino, Maria Antonietta
AU  - Kumar, Sunil
AU  - Workeneh, Biruh
AU  - Rae, Julie
AU  - Mao, Huiyan A.
AU  - Erblang, Felix
AU  - Meier, Oliver
AU  - Maller, Justine C.
AU  - Askanase, Anca D.
TI  - Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
PY  - 2026
SN  - 0028-4793
DO  - 10.1056/NEJMoa2516150
UR  - https://m2.mtmt.hu/api/publication/37071448
ID  - 37071448
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Doshi, S. K.
AU  - Kar, S.
AU  - Nair, D. G.
AU  - Waggoner, T.
AU  - Agarwal, H.
AU  - Moussavian, M.
AU  - Kashani, A.
AU  - Oza, S.
AU  - Feldman, L.
AU  - Sadhu, A.
AU  - DeLurgio, D.
AU  - Alli, O.
AU  - Nielsen-Kudsk, J. E.
AU  - Yamamoto, M.
AU  - Alkhouli, M.
AU  - Camm, A. J.
AU  - Coylewright, M.
AU  - Gibson, C. M.
AU  - Granger, C. B.
AU  - Gurol, M. E.
AU  - Huber, K. C.
AU  - Mansour, M.
AU  - Natale, A.
AU  - Pocock, S. J.
AU  - Reddy, V. Y.
AU  - Saliba, W. I.
AU  - Asch, F. M.
AU  - Wehrenberg, S.
AU  - Frost, K.
AU  - Christen, T.
AU  - Sutton, B. S.
AU  - Stein, K. M.
AU  - Leon, M. B.
AU  - Ellenbogen, K. A.
TI  - Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
PY  - 2026
PG  - 11
SN  - 0028-4793
DO  - 10.1056/NEJMoa2517213
UR  - https://m2.mtmt.hu/api/publication/37153712
ID  - 37153712
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Diletti, Roberto
AU  - Daemen, Joost
AU  - Faurie, Benjamin
AU  - Barbierato, Marco
AU  - Tchetche, Didier
AU  - Hovasse, Thomas
AU  - Teeuwen, Koen
AU  - Cheng, Jin M.
AU  - Landt, Martin
AU  - Campo, Gianluca
AU  - Bennett, Johan
AU  - Alfonso, Fernando
AU  - Mashayekhi, Kambis
AU  - Moreno, Raul
AU  - Abdelwahed, Youssef S.
AU  - Heestermans, Ton
AU  - de la Torre Hernandez, Jose M.
AU  - Murphy, John C.
AU  - Amat-Santos, Ignacio
AU  - Dens, Joseph
AU  - Franze, Alfonso
AU  - Leistner, David M.
AU  - Ghattas, Angie
AU  - Spratt, James C.
AU  - Banning, Adrian P.
AU  - Tijssen, Jan G. P.
AU  - Spitzer, Ernest
AU  - Van Mieghem, Nicolas M.
TI  - Intravascular Ultrasound-Guided or Angiography-Guided Complex High-Risk PCI
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
PY  - 2026
PG  - 12
SN  - 0028-4793
DO  - 10.1056/NEJMoa2601521
UR  - https://m2.mtmt.hu/api/publication/37179184
ID  - 37179184
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Testa, Luca
AU  - Hernandez, Jose Maria De la Torre
AU  - De Maria, Giovanni Luigi
AU  - Jones, Daniel A.
AU  - Pinon-Esteban, Pablo
AU  - Campo, Gianluca
AU  - del Blanco, Bruno Garcia
AU  - Pan, Manuel
AU  - Garcia-Camarero, Tamara
AU  - Sardella, Gennaro
AU  - O'kane, Peter
AU  - Greenwood, John P.
AU  - Ribichini, Flavio L.
AU  - Pescetelli, Irene
AU  - Ielasi, Alfonso
AU  - Lozano, Inigo
AU  - Cockburn, James
AU  - Oreglia, Jacopo A.
AU  - Zaman, Azfar G.
AU  - Bedogni, Francesco
AU  - Lindeboom, Wietze
AU  - Tijssen, Jan G. P.
AU  - Spitzer, Ernest
AU  - Banning, Adrian P.
TI  - IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
PY  - 2026
PG  - 11
SN  - 0028-4793
DO  - 10.1056/NEJMoa2600440
UR  - https://m2.mtmt.hu/api/publication/37179187
ID  - 37179187
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fearon, William F.
AU  - Jeremias, Allen
AU  - Witberg, Guy
AU  - Al-Lamee, Rasha
AU  - Cohen, David J.
AU  - Kaki, Amir
AU  - Sharma, Rahul P.
AU  - Yeh, Robert W.
AU  - Chehab, Bassem M.
AU  - Kim, Michael C.
AU  - Otake, Hiromasa
AU  - Tayal, Rajiv
AU  - Matsuo, Hitoshi
AU  - Mcentegart, Margaret
AU  - Patel, Ankitkumar K.
AU  - Sandoval, Yader
AU  - Al-Azizi, Karim M.
AU  - Dan, Kazuhiro
AU  - Razzouk, Louai
AU  - Fournier, Stephane
AU  - Popma, Alexandra
AU  - Popma, Jeffrey J.
AU  - Zhao, Duzhi
AU  - Redfors, Bjorn
AU  - Madhavan, Mahesh V.
AU  - Kornowski, Ran
AU  - Leon, Martin B.
AU  - Kirtane, Ajay J.
TI  - Angiography-Derived Fractional Flow Reserve to Guide PCI
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
PY  - 2026
PG  - 11
SN  - 0028-4793
DO  - 10.1056/NEJMoa2600949
UR  - https://m2.mtmt.hu/api/publication/37190328
ID  - 37190328
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Chatzizisis, Yiannis S.
TI  - Redefining Physiology in the Cardiac Catheterization Laboratory
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
PY  - 2026
PG  - 2
SN  - 0028-4793
DO  - 10.1056/NEJMe2603714
UR  - https://m2.mtmt.hu/api/publication/37190370
ID  - 37190370
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Marcus, Gregory M.
TI  - Left Atrial Appendage Closure - Should Recommendations Be Expanded?
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
PY  - 2026
PG  - 2
SN  - 0028-4793
DO  - 10.1056/NEJMe2603846
UR  - https://m2.mtmt.hu/api/publication/37206755
ID  - 37206755
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Welt, Frederick
TI  - Seeing the Left Main Coronary Artery Clearly - Is IVUS Always Necessary?
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
PY  - 2026
PG  - 2
SN  - 0028-4793
DO  - 10.1056/NEJMe2602959
UR  - https://m2.mtmt.hu/api/publication/37218602
ID  - 37218602
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Barco, Stefano
AU  - Engelberger, Rolf P.
AU  - Held, Ulrike
AU  - Fumagalli, Riccardo M.
AU  - Grigorean, Alexandru
AU  - Hayoz, Daniel
AU  - Munger, Mario
AU  - Sebastian, Tim
AU  - Stadler, Roman
AU  - Voci, Davide
AU  - Wolf, Simon
AU  - Baumann, Frederic
AU  - Tritschler, Tobias
AU  - von Stempel, Conrad
AU  - Periard, Daniel
AU  - Kucher, Nils
TI  - Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
PY  - 2026
PG  - 10
SN  - 0028-4793
DO  - 10.1056/NEJMoa2600360
UR  - https://m2.mtmt.hu/api/publication/37270512
ID  - 37270512
LA  - English
DB  - MTMT
ER  -