@article{MTMT:37058755, title = {Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease}, url = {https://m2.mtmt.hu/api/publication/37058755}, author = {Lee, Yong-Joon and Lee, Seung-Jun and Kim, Jin Won and Lee, Sang-Hyup and Kim, Gwang-Sil and Park, Jae Hyoung and Cho, Jin-Man and Kang, Woong Chol and Yoon, Hyuck-Jun and Kim, Won Ho and Lee, Seung-Jin and Lee, Jin Bae and Jang, Ji-Yong and Shin, Sanghoon and Park, Ik Hyun and Kwon, Sung Uk and Kim, Sunwon and Hong, Sung-Jin and Ahn, Chul-Min and Kim, Jung-Sun and Ko, Young-Guk and Choi, Donghoon and Hong, Myeong-Ki and Jang, Yangsoo and Kim, Byeong-Keuk}, doi = {10.1056/NEJMoa2600283}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, volume = {394}, unique-id = {37058755}, issn = {0028-4793}, abstract = {Background Despite guideline recommendations, evidence from randomized trials evaluating the appropriate low-density lipoprotein (LDL) cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease remains limited.Methods In this open-label superiority trial conducted in South Korea, we randomly assigned patients with atherosclerotic cardiovascular disease in a 1:1 ratio to a target LDL cholesterol level of less than 55 mg per deciliter (1.4 mmol per liter) (intensive-targeting group) or less than 70 mg per deciliter (1.8 mmol per liter) (conventional-targeting group). The primary end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, any revascularization, or hospitalization for unstable angina at 3 years. Safety was also assessed.Results Of 3048 patients who underwent randomization, 1526 were assigned to the intensive-targeting group and 1522 to the conventional-targeting group. The median follow-up was 3.0 years. The median LDL cholesterol level during the trial was 56 mg per deciliter (1.4 mmol per liter) in the intensive-targeting group and 66 mg per deciliter (1.7 mmol per liter) in the conventional-targeting group. A primary end-point event occurred in 100 patients (Kaplan-Meier estimate of cumulative incidence, 6.6%) in the intensive-targeting group and in 147 patients (Kaplan-Meier estimate of cumulative incidence, 9.7%) in the conventional-targeting group (hazard ratio, 0.67; 95% confidence interval, 0.52 to 0.86; P=0.002). The incidence of prespecified safety end points was similar in the two trial groups, except for a lower incidence of creatinine elevation in the intensive-targeting group.Conclusions Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level of less than 55 mg per deciliter resulted in a lower risk of cardiovascular events at 3 years than targeting a level of less than 70 mg per deciliter. (Funded by the Cardiovascular Research Center and Yuhan; Ez-PAVE ClinicalTrials.gov number, NCT04626973.) Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter.}, keywords = {MANAGEMENT; OUTCOMES; ATORVASTATIN; ezetimibe; statin therapy}, year = {2026}, eissn = {1533-4406}, pages = {1365-1375} } @article{MTMT:37071448, title = {Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus}, url = {https://m2.mtmt.hu/api/publication/37071448}, author = {Furie, Richard A. and Dall'era, Maria and Vital, Edward M. and Garg, Jay P. and Irazoque, Palazuelos Fedra and Zuta, Santillan Adolfina E. and Ravelo-Hernandez, Jorge and Santiago, Mittermayer B. and Zazueta, Montiel Beatriz and Botha, Stella and Leszczynski, Piotr and de, Souza Viviane Angelina and Sicsik, Sandra A. and Bellatin, Luis and Naidoo, Asokan and Amoura, Zahir and D'Dgostino, Maria Antonietta and Kumar, Sunil and Workeneh, Biruh and Rae, Julie and Mao, Huiyan A. and Erblang, Felix and Meier, Oliver and Maller, Justine C. and Askanase, Anca D.}, doi = {10.1056/NEJMoa2516150}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, unique-id = {37071448}, issn = {0028-4793}, year = {2026}, eissn = {1533-4406} } @article{MTMT:37153712, title = {Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation}, url = {https://m2.mtmt.hu/api/publication/37153712}, author = {Doshi, S. K. and Kar, S. and Nair, D. G. and Waggoner, T. and Agarwal, H. and Moussavian, M. and Kashani, A. and Oza, S. and Feldman, L. and Sadhu, A. and DeLurgio, D. and Alli, O. and Nielsen-Kudsk, J. E. and Yamamoto, M. and Alkhouli, M. and Camm, A. J. and Coylewright, M. and Gibson, C. M. and Granger, C. B. and Gurol, M. E. and Huber, K. C. and Mansour, M. and Natale, A. and Pocock, S. J. and Reddy, V. Y. and Saliba, W. I. and Asch, F. M. and Wehrenberg, S. and Frost, K. and Christen, T. and Sutton, B. S. and Stein, K. M. and Leon, M. B. and Ellenbogen, K. A.}, doi = {10.1056/NEJMoa2517213}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, unique-id = {37153712}, issn = {0028-4793}, year = {2026}, eissn = {1533-4406} } @article{MTMT:37179184, title = {Intravascular Ultrasound-Guided or Angiography-Guided Complex High-Risk PCI}, url = {https://m2.mtmt.hu/api/publication/37179184}, author = {Diletti, Roberto and Daemen, Joost and Faurie, Benjamin and Barbierato, Marco and Tchetche, Didier and Hovasse, Thomas and Teeuwen, Koen and Cheng, Jin M. and Landt, Martin and Campo, Gianluca and Bennett, Johan and Alfonso, Fernando and Mashayekhi, Kambis and Moreno, Raul and Abdelwahed, Youssef S. and Heestermans, Ton and de la Torre Hernandez, Jose M. and Murphy, John C. and Amat-Santos, Ignacio and Dens, Joseph and Franze, Alfonso and Leistner, David M. and Ghattas, Angie and Spratt, James C. and Banning, Adrian P. and Tijssen, Jan G. P. and Spitzer, Ernest and Van Mieghem, Nicolas M.}, doi = {10.1056/NEJMoa2601521}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, unique-id = {37179184}, issn = {0028-4793}, year = {2026}, eissn = {1533-4406} } @article{MTMT:37179187, title = {IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease}, url = {https://m2.mtmt.hu/api/publication/37179187}, author = {Testa, Luca and Hernandez, Jose Maria De la Torre and De Maria, Giovanni Luigi and Jones, Daniel A. and Pinon-Esteban, Pablo and Campo, Gianluca and del Blanco, Bruno Garcia and Pan, Manuel and Garcia-Camarero, Tamara and Sardella, Gennaro and O'kane, Peter and Greenwood, John P. and Ribichini, Flavio L. and Pescetelli, Irene and Ielasi, Alfonso and Lozano, Inigo and Cockburn, James and Oreglia, Jacopo A. and Zaman, Azfar G. and Bedogni, Francesco and Lindeboom, Wietze and Tijssen, Jan G. P. and Spitzer, Ernest and Banning, Adrian P.}, doi = {10.1056/NEJMoa2600440}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, unique-id = {37179187}, issn = {0028-4793}, year = {2026}, eissn = {1533-4406} } @article{MTMT:37190328, title = {Angiography-Derived Fractional Flow Reserve to Guide PCI}, url = {https://m2.mtmt.hu/api/publication/37190328}, author = {Fearon, William F. and Jeremias, Allen and Witberg, Guy and Al-Lamee, Rasha and Cohen, David J. and Kaki, Amir and Sharma, Rahul P. and Yeh, Robert W. and Chehab, Bassem M. and Kim, Michael C. and Otake, Hiromasa and Tayal, Rajiv and Matsuo, Hitoshi and Mcentegart, Margaret and Patel, Ankitkumar K. and Sandoval, Yader and Al-Azizi, Karim M. and Dan, Kazuhiro and Razzouk, Louai and Fournier, Stephane and Popma, Alexandra and Popma, Jeffrey J. and Zhao, Duzhi and Redfors, Bjorn and Madhavan, Mahesh V. and Kornowski, Ran and Leon, Martin B. and Kirtane, Ajay J.}, doi = {10.1056/NEJMoa2600949}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, unique-id = {37190328}, issn = {0028-4793}, year = {2026}, eissn = {1533-4406} } @article{MTMT:37190370, title = {Redefining Physiology in the Cardiac Catheterization Laboratory}, url = {https://m2.mtmt.hu/api/publication/37190370}, author = {Chatzizisis, Yiannis S.}, doi = {10.1056/NEJMe2603714}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, unique-id = {37190370}, issn = {0028-4793}, year = {2026}, eissn = {1533-4406} } @article{MTMT:37206755, title = {Left Atrial Appendage Closure - Should Recommendations Be Expanded?}, url = {https://m2.mtmt.hu/api/publication/37206755}, author = {Marcus, Gregory M.}, doi = {10.1056/NEJMe2603846}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, unique-id = {37206755}, issn = {0028-4793}, year = {2026}, eissn = {1533-4406} } @article{MTMT:37218602, title = {Seeing the Left Main Coronary Artery Clearly - Is IVUS Always Necessary?}, url = {https://m2.mtmt.hu/api/publication/37218602}, author = {Welt, Frederick}, doi = {10.1056/NEJMe2602959}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, unique-id = {37218602}, issn = {0028-4793}, year = {2026}, eissn = {1533-4406} } @article{MTMT:37270512, title = {Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease}, url = {https://m2.mtmt.hu/api/publication/37270512}, author = {Barco, Stefano and Engelberger, Rolf P. and Held, Ulrike and Fumagalli, Riccardo M. and Grigorean, Alexandru and Hayoz, Daniel and Munger, Mario and Sebastian, Tim and Stadler, Roman and Voci, Davide and Wolf, Simon and Baumann, Frederic and Tritschler, Tobias and von Stempel, Conrad and Periard, Daniel and Kucher, Nils}, doi = {10.1056/NEJMoa2600360}, journal-iso = {NEW ENGL J MED}, journal = {NEW ENGLAND JOURNAL OF MEDICINE}, unique-id = {37270512}, issn = {0028-4793}, year = {2026}, eissn = {1533-4406}, orcid-numbers = {Tritschler, Tobias/0000-0002-8775-0511; von Stempel, Conrad/0000-0002-3088-2775} }