@article{MTMT:34619018, title = {Distinguishing multicystic from focal encephalomalacia on delayed MRI in children with term hypoxic ischemic injury}, url = {https://m2.mtmt.hu/api/publication/34619018}, author = {Alkhulaifat, Dana and Venkatakrishna, Shyam Sunder B. and Alves, Cesar Augusto Pinheiro Ferreira and Lerebo, Wondwossen and Tierradentro-Garcia, Luis Octavio and Elsingergy, Mohamed and Worede, Fikadu and Curic, Jelena and Andronikou, Savvas}, doi = {10.1111/jon.13190}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, unique-id = {34619018}, issn = {1051-2284}, abstract = {Background and Purpose: To define cystic patterns resulting from term hypoxic ischemic injury (HII) on delayed Magnetic Resonance Imaging (MRI) and determine associated HII patterns and lesions that reflect the severity of injury, from a database of African children with cerebral palsy.Methods: Retrospective review of 1175 children with cerebral palsy due to term HII diagnosed on late MRI, identifying those with cystic changes. These were classified as multicystic or (multi-) focal-cystic, and were evaluated for associated injuries-thalami, basal ganglia, hippocampi, cerebellum, and presence of ulegyria.Results: Three hundred and eighty-eight of 1175 (33%) children had cystic encephalomalacia. Two hundred and seven of 388 (53.3%) had focal-cystic and 181/388 (46.6%) had multicystic injury. The focal-cystic group comprised 87.9% (182/207) with thalamic injury, 25.6% (53/207) with basal ganglia injury, and 15% (31/207) with cerebellar involvement. Basal-ganglia-thalamus (BGT) pattern was present in 43.9% (91/207) and ulegyria in 69.6% (144/207). In the multicystic group, 88.9% (161/181) had thalamic injury, 30.9% (56/181) had basal ganglia injury, and 21% (38/181) had cerebellar involvement. BGT pattern was observed in 29.8% (54/181) and ulegyria in 28.7%. (52/181). Significant associations (p<.05) were found between multicystic injury and caudate/globus pallidus involvement, and between focal-cystic pattern of injury and ulegyria.Conclusions: Cystic encephalomalacia was seen in almost one-third of patients with term HII imaged with delayed MRI, with a similar prevalence of focal-cystic and multicystic injury. Multicystic injury was associated with caudate and globus pallidi involvement, typical of the BGT pattern of HII, whereas the focal-cystic pattern was associated with ulegyria, typical of watershed injury.}, keywords = {Magnetic Resonance Imaging; watershed; hypoxic ischemic injury; multicystic encephalomalacia}, year = {2024}, eissn = {1552-6569}, orcid-numbers = {Alkhulaifat, Dana/0000-0003-1066-5279} } @article{MTMT:34609512, title = {Sex differences in development of functional connections in the face processing network}, url = {https://m2.mtmt.hu/api/publication/34609512}, author = {Nowling, Duncan and Crum, Kathleen I. and Joseph, Jane}, doi = {10.1111/jon.13185}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, unique-id = {34609512}, issn = {1051-2284}, abstract = {Background and PurposeUnderstanding sex differences in typical development of the face processing network is important for elucidating disruptions during atypical development in sex-linked developmental disorders like autism spectrum disorder. Based on prior sex difference studies in other cognitive domains, this study examined whether females show increased integration of core and extended face regions with age for face viewing, while males would show increased segregation.MethodsThis study used a cross-sectional design with typically developing children and adults (n = 133) and a functional MRI face localizer task. Psychophysiological interaction (PPI) analysis examined functional connectivity between canonical and extended face processing network regions with age, with greater segregation indexed by decreased core-extended region connectivity with age and greater integration indexed by increased core-extended region connectivity with age.ResultsPPI analysis confirmed increased segregation for males-right fusiform face area (FFA) coupling to right inferior frontal gyrus (IFG) opercular when viewing faces and left amygdala when viewing objects decreased with age. Females showed increased integration with age (increased coupling of the right FFA to right IFG opercular region and right occipital face area [OFA] to right IFG orbital when viewing faces and objects, respectively) and increased segregation (decreased coupling with age of the right OFA with IFG opercular region when viewing faces).ConclusionsDevelopment of core and extended face processing network connectivity follows sexually dimorphic paths. These differential changes mostly occur across childhood and adolescence, with males experiencing segregation and females both segregation and integration changes in connectivity.}, keywords = {FMRI; FUSIFORM FACE AREA; occipital face area; inferior frontal opercular cortex}, year = {2024}, eissn = {1552-6569} } @article{MTMT:34601865, title = {Self-expanding versus balloon expandable stent for intracranial arterial stenosis: A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34601865}, author = {Qureshi, Adnan I. and Lodhi, Abdullah and Ma, Xiaoyu and Ahmed, Rehan and Kwok, Chun Shing and Maqsood, Hamza and Liaqat, Jahanzeb and Hassan, Ameer E. and Siddiq, Farhan and Gomez, Camilo R. and Suri, M. Fareed K.}, doi = {10.1111/jon.13188}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, unique-id = {34601865}, issn = {1051-2284}, abstract = {Background and Purpose: There are limited data regarding the comparison of balloon expandable stents (BES) and self-expanding stents (SES) for the treatment of intracranial arterial stenosis.Methods: We conducted a systematic review to identify studies that compared SES and BES in patients with symptomatic intracranial arterial stenosis. Data were extracted from relevant studies found through a search of PubMed, Scopus, and Web of Science until from January 1, 2010 to September 28, 2023. Statistical pooling with random-effects meta-analysis was undertaken to compare the rates/severity of postprocedure stenosis, technical success, 30-day stroke and/or death, cumulative clinical endpoints, and restenosis rates.Results: A total of 20 studies were included. The standardized mean difference (SMD) for postprocedure stenosis (%) was significantly lower (SMD: -0.52, 95% confidence interval [CI]: -0.79 to -0.24, p < .001, 10 studies involving 1515 patients) with BES. The odds for 30-day stroke and/or death were significantly lower (odds ratio [OR] 0.68, 95% CI: 0.50-0.94, p = .019, 15 studies involving 2431 patients), and cumulative clinical endpoints on follow-up were nonsignificantly lower (OR 0.64, 95% CI: 0.30-1.37, p = .250, 10 studies involving 947 patients) with BES. The odds for restenosis during follow-up were significantly lower (OR 0.50, 95% CI: 0.31-0.80, p = .004, 13 studies involving 1115 patients) with BES.Conclusions: Compared with SES, BES were associated with lower rates of postprocedure 30-day stroke and/or death with lower rates of restenosis during follow up and the treatment of symptomatic intracranial arterial stenosis.}, keywords = {Restenosis; Intracranial stenosis; Intracranial atherosclerosis; self-expanding stents; balloon expandable stents}, year = {2024}, eissn = {1552-6569}, orcid-numbers = {Lodhi, Abdullah/0000-0002-8180-7855; Maqsood, Hamza/0000-0001-5721-9511} } @article{MTMT:34603755, title = {A longitudinal analysis of brain volume changes in myelin oligodendrocyte glycoprotein antibody-associated disease}, url = {https://m2.mtmt.hu/api/publication/34603755}, author = {Amin, Mohammad and Al-iedani, Oun and Lea, Rodney A. and Brilot, Fabienne and Maltby, Vicki E. and Lechner-Scott, Jeannette}, doi = {10.1111/jon.13175}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, volume = {34}, unique-id = {34603755}, issn = {1051-2284}, abstract = {Background and Purpose: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a relapsing demyelinating condition. There are several cross-sectional studies showing evidence of brain atrophy in people with MOGAD (pwMOGAD), but longitudinal brain volumetric assessment is still an unmet need. Current recommendations do not include monitoring with MRI and assume distinct attacks. Evidence of ongoing axon loss will have diagnostic and therapeutic implications. In this study, we assessed brain volume changes in pwMOGAD over a mean follow-up period of 2 years and compared this to changes in people with multiple sclerosis (pwMS).Methods: This is a retrospective single-center study over a 7-year period from 2014 to 2021. MRI brain scans at the time of diagnosis and follow-up in remission were collected from 14 Caucasian pwMOGAD, confirmed by serum myelin oligodendrocyte glycoprotein immunoglobulin G antibody presence, detected by live cell-based assays. Total brain volume (TBV), white matter (WM), gray matter (GM), and demyelinating lesion volumes were assessed automatically using the Statistical Parametric Mapping and FMRIB automated segmentation tools. MRI brain scans at diagnosis and follow-up on remission were collected from 32-matched pwMS for comparison. Statistical analysis was done using analysis of variance.Results: There is evidence of TBV loss, affecting particularly GM, over an approximately 2-year follow-up period in pwMOGAD (p < .05), comparable to pwMS. WM and lesion volume change over the same period were not statistically significant (p > .1).Conclusion: We found evidence of loss of GM and TBV over time in pwMOGAD, similar to pwMS, although the WM and lesion volumes were unchanged.}, keywords = {MULTIPLE SCLEROSIS; cell-based assay; volumetric MRI; statistical parametric mapping (SPM12); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); FMRIB Automated Segmentation Tool (FSL-FAST)}, year = {2024}, eissn = {1552-6569}, pages = {78-85}, orcid-numbers = {Al-iedani, Oun/0000-0002-3112-4482} } @article{MTMT:34586014, title = {Concordance of verbal memory and language fMRI lateralization in people with epilepsy}, url = {https://m2.mtmt.hu/api/publication/34586014}, author = {Kokkinos, Vasileios and Seimenis, Ioannis}, doi = {10.1111/jon.13171}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, volume = {34}, unique-id = {34586014}, issn = {1051-2284}, abstract = {Background and Purpose: This work investigates verbal memory functional MRI (fMRI) versus language fMRI in terms of lateralization, and assesses the validity of performing word recognition during the functional scan.Methods: Thirty patients with a diagnosis of epilepsy underwent verbal memory, visuospatial memory, and language fMRI. We used word encoding, word recognition, image encoding, and image recognition memory tasks, and semantic description, reading comprehension, and listening comprehension language tasks. We used three common lateralization metrics: network spatial distribution, maximum statistical value, and laterality index (LI).Results: Lateralization of signal spatial distribution resulted in poor similarity between verbal memory and language fMRI tasks. Signal maximum lateralization showed significant (>.8) but not perfect (1) similarity. Word encoding LI showed significant correlation only with listening comprehension LI (p = .016). Word recognition LI was significantly correlated with expressive language semantic description LI (p = .024) and receptive language reading and listening comprehension LIs (p = .015 and p = .019, respectively). There was no correlation between LIs of the visuospatial tasks and LIs of the language tasks.Conclusions: Our results support the association between language and verbal memory lateralization, optimally determined by LI quantification, and the introduction of quantitative means for language fMRI interpretation in clinical settings where verbal memory lateralization is imperative.}, keywords = {EPILEPSY; Functional Neuroimaging; presurgical evaluation; memory fMRI}, year = {2024}, eissn = {1552-6569}, pages = {95-107}, orcid-numbers = {Kokkinos, Vasileios/0000-0002-4309-5455} } @article{MTMT:34265243, title = {The distribution pattern of nerve enlargement in clinical subtypes of chronic inflammatory demyelinating polyneuropathy}, url = {https://m2.mtmt.hu/api/publication/34265243}, author = {Niu, Jingwen and Zhang, Lei and Hu, Nan and Cui, Liying and Liu, Mingsheng}, doi = {10.1111/jon.13162}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, volume = {34}, unique-id = {34265243}, issn = {1051-2284}, abstract = {Background and PurposeWe aim to investigate nerve enlargement patterns and their correlation with clinical subtypes and treatment response using nerve ultrasound in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).MethodsBetween March 2015 and December 2021, 135 CIDP patients were recruited. Nerve ultrasound and electrophysiological studies were performed on the median and ulnar nerves. The responses to intravenous immunoglobulin (IVIg) or prednisone were evaluated with the disability score.ResultsThere were 99 typical CIDP cases, 10 Lewis-Sumner syndrome (LSS) cases, 15 distal acquired demyelinating symmetric neuropathy (DADS) cases, nine pure motor CIDP cases, and two pure sensory CIDP cases. Sixty (61%) typical CIDP and seven (78%) pure motor CIDP patients had moderately increased or normal cross-sectional area (CSA), and 10 (67%) DADS and seven (70%) LSS patients had significantly increased CSA. The peripheral nerve showed a diffuse enlargement pattern in 46 (51%) typical CIDP, five (50%) LSS, three (25%) DADS, and three (33%) pure motor CIDP patients and a proximal regional enlargement pattern in 11 (12%) typical CIDP, one (10%) LSS, six (50%) DADS, and four (44%) pure motor CIDP patients. Patients with diffusely moderate enlargement patterns and those with proximal regional enlargement showed a higher response rate to glucocorticoids than to IVIg.ConclusionsVarious distribution patterns of nerve enlargement existed in CIDP. Although almost all patterns could be detected in each CIDP subtype, diffusely moderate enlargement was more common in typical CIDP and LSS, while proximal regional enlargement was more common in DADS and pure motor CIDP. Different enlargement patterns might indicate different treatment responses.}, keywords = {treatment response; Nerve ultrasound; chronic inflammatory demyelinating polyradiculoneuropathy; clinical subtype of CIDP; nerve enlargement pattern}, year = {2024}, eissn = {1552-6569}, pages = {127-137} } @article{MTMT:34264314, title = {An imaging review of the hippocampus and its common pathologies}, url = {https://m2.mtmt.hu/api/publication/34264314}, author = {Lang, Min and Colby, Samantha and Ashby-Padial, Christian and Bapna, Monika and Jaimes, Camilo and Rincon, Sandra P. and Buch, Karen}, doi = {10.1111/jon.13165}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, volume = {34}, unique-id = {34264314}, issn = {1051-2284}, year = {2024}, eissn = {1552-6569}, pages = {5-25} } @article{MTMT:34270451, title = {Short-term brain atrophy evolution after initiation of immunotherapy in a real-world multiple sclerosis cohort}, url = {https://m2.mtmt.hu/api/publication/34270451}, author = {Nold, Ann-Kathrin and Wittayer, Matthias and Weber, Claudia E. and Platten, Michael and Gass, Achim and Eisele, Philipp}, doi = {10.1111/jon.13146}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, unique-id = {34270451}, issn = {1051-2284}, abstract = {Background and PurposeIn multiple sclerosis (MS), brain atrophy measurements have emerged as an important biomarker reflecting neurodegeneration and disability progression. However, due to several potential confounders, investigation of brain atrophy in clinical routine and even in controlled clinical studies can be challenging. The aim of this study was to investigate the short-term dynamics of brain atrophy development after initiation of disease-modifying therapy (DMT) in a "real-world setting." MethodsIn this retrospective study, we included MS patients starting DMT (natalizumab, fingolimod, dimethyl fumarate, or interferon-ss1a) or without DMT, availability of a baseline MRI, and two annual follow-up scans on the same MRI system. Two-timepoint percentage brain volume changes (PBVCs) were calculated. ResultsFifty-five MS patients (12 patients starting DMT with natalizumab, 7 fingolimod, 14 dimethyl fumarate, 11 interferon-ss1a, and 11 patients without DMT) were included. We found the highest PBVCs in the first 12 months after initiation of natalizumab treatment. Furthermore, the PBVCs in our study were very much comparable to the results observed by other groups, as well as for fingolimod, dimethyl fumarate, and interferon-ss1a. ConclusionWe found PBVCs that are comparable to the results of previous studies, suggesting that brain atrophy, assessed on 3D MRI data sets acquired on the same 3T MRI, provides a robust MS biomarker.}, keywords = {MULTIPLE SCLEROSIS; BRAIN ATROPHY; MRI}, year = {2023}, eissn = {1552-6569}, orcid-numbers = {Platten, Michael/0000-0002-4746-887X; Eisele, Philipp/0000-0001-6831-4282} } @article{MTMT:34087571, title = {Impact of postnatal weight gain on brain white matter maturation in very preterm infants}, url = {https://m2.mtmt.hu/api/publication/34087571}, author = {Bobba, P.S. and Weber, C.F. and Higaki, A.R.A. and Mukherjee, P. and Scheinost, D. and Constable, R.T. and Ment, L. and Taylor, S.N. and Payabvash, S.}, doi = {10.1111/jon.13145}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, volume = {In press}, unique-id = {34087571}, issn = {1051-2284}, abstract = {Background and Purpose: Very preterm infants (VPIs, <32 weeks gestational age at birth) are prone to long-term neurological deficits. While the effects of birth weight and postnatal growth on VPIs’ neurological outcome are well established, the neurobiological mechanism behind these associations remains elusive. In this study, we utilized diffusion tensor imaging (DTI) to characterize how birth weight and postnatal weight gain influence VPIs’ white matter (WM) maturation. Methods: We included VPIs with complete birth and postnatal weight data in their health record, and DTI scan as part of their predischarge Magnetic Resonance Imaging (MRI). We conducted voxel-wise general linear model and tract-based regression analyses to explore the impact of birth weight and postnatal weight gain on WM maturation. Results: We included 91 VPIs in our analysis. After controlling for gestational age at birth and time between birth and scan, higher birth weight Z-scores were associated with DTI markers of more mature WM tracts, most prominently in the corpus callosum and sagittal striatum. The postnatal weight Z-score changes over the first 4 weeks of life were also associated with increased maturity in these WM tracts, when controlling for gestational age at birth, birth weight Z-score, and time between birth and scan. Conclusions: In VPIs, birth weight and post-natal weight gain are associated with markers of brain WM maturation, particularly in the corpus callosum, which can be captured on discharge MRI. These neuroimaging metrics can serve as potential biomarkers for the early effects of nutritional interventions on VPIs’ brain development. © 2023 American Society of Neuroimaging.}, keywords = {PRETERM INFANTS; Diffusion imaging; White matter maturation}, year = {2023}, eissn = {1552-6569}, pages = {In press} } @article{MTMT:33967874, title = {Neuroimaging features of FOXR2-activated CNS neuroblastoma: A case series and systematic review}, url = {https://m2.mtmt.hu/api/publication/33967874}, author = {Shimazaki, Kenichiro and Kurokawa, Ryo and Franson, Andrea and Kurokawa, Mariko and Baba, Akira and Bou-Maroun, Laura and Kim, John and Moritani, Toshio}, doi = {10.1111/jon.13095}, journal-iso = {J NEUROIMAGING}, journal = {JOURNAL OF NEUROIMAGING}, unique-id = {33967874}, issn = {1051-2284}, abstract = {Background and PurposeCNS neuroblastoma, FOXR2-activated (CNS NB-FOXR2) is a newly recognized tumor type in the 2021 World Health Organization classification of central nervous system (CNS) tumors. We aimed to investigate the clinical and neuroimaging findings of CNS NB-FOXR2 and systematically review previous publications and three new cases. MethodsWe searched PubMed, SCOPUS, and Embase databases for patients with pathologically proven CNS NB-FOXR2 with sufficient information for preoperative CT and MRI findings. Two board-certified radiologists reviewed the studies and imaging data. ResultsThirty-one patients from six previous publications and 3 patients from our hospital comprised the study population (median age, 4.2 [range: 1.4-16] years; 19 girls). Clinically, CNS NB-FOXR2 mainly affected children between 2 and 6 years (24/34, 67.6%). Nausea/vomiting and seizures were reported as the main presenting symptoms (100% in total). The tumors frequently showed hyperdensity compared to the cortex on nonenhanced CT (4/5, 80%) with calcification along the inner rim of the tumor (4/5, 80%). More than half of patients showed susceptibility artifacts indicating intratumoral hemorrhage and/or calcification (15/28, 53.6%) on T2*- and/or susceptibility-weighted imaging. Elevated relative cerebral blood volume and flow and percentile signal recovery were observed in one case with dynamic susceptibility contrast MRI. ConclusionsCharacteristic imaging features including hyperdense attenuation of the solid components and calcification along the inner rim on CT and susceptibility-weighted imaging may assist with preoperative diagnosis of CNS NB-FOXR2 in pediatric patients.}, keywords = {Magnetic Resonance Imaging; NEUROBLASTOMA; computed tomography; systematic review; FOXR2}, year = {2023}, eissn = {1552-6569}, orcid-numbers = {Franson, Andrea/0000-0002-5361-7683; Kurokawa, Mariko/0000-0002-3907-9188; Baba, Akira/0000-0001-6913-5307} }