TY - JOUR AU - Awalt, S.L. AU - Boghean, L. AU - Klinkebiel, D. AU - Strasser, R. TI - A dog's life: Early life histories influence methylation of glucocorticoid (NR3C1) and oxytocin (OXTR) receptor genes, cortisol levels, and attachment styles JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 66 PY - 2024 IS - 3 SN - 0012-1630 DO - 10.1002/dev.22482 UR - https://m2.mtmt.hu/api/publication/34761820 ID - 34761820 N1 - Neuroscience & Behavior Program, Department of Psychology, University of Nebraska Omaha, Omaha, NE, United States Department of Biochemistry and Molecular Biology, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, United States Export Date: 28 March 2024 CODEN: DEPBA Correspondence Address: Strasser, R.; & Behavior Program, Neuroscience, 6001 Dodge St., United States; email: rstrasser@unomaha.edu Chemicals/CAS: hydrocortisone, 50-23-7; oxytocin, 50-56-6, 54577-94-5; Glucocorticoids; Hydrocortisone; NR3C1 protein, human; OXTR protein, human; Oxytocin; Receptors, Glucocorticoid; Receptors, Oxytocin AB - Early life deprivation and stress can contribute to life-long, problematic consequences, including epigenetic variations related to behavior and health. Domestic dogs share human environments and social–cognitive traits, making them a promising comparative model to examine developmental plasticity. We examined 47 owner–dog dyads, including dogs rescued from abusive or neglectful environments, and matched control dogs for changes in DNA methylation of glucocorticoid (NR3C1) and oxytocin (OXTR) receptor genes previously shown to be affected by early life stress in other species including humans. We used an attachment paradigm, which included a separation event to examine cortisol levels and owner–dog attachment styles. Overall, dogs with adverse histories had different NR3C1 methylation patterns as a function of age and less OXTR methylation than comparison dogs. Dogs with adverse histories did not differ in their cortisol change from baseline to poststressor from comparison dogs, but the change in cortisol was associated with NR3C1 methylation. In addition, dogs with a history of early life stress had more insecure attachment styles; for every unit increase of OXTR methylation, the odds increased for insecure attachment style. This study demonstrates that adverse life histories lead to methylation differences, resulting in the hypothalamic–pituitary–adrenal (HPA) axis's dysregulation and differences in behavioral phenotypes. © 2024 The Authors. Developmental Psychobiology published by Wiley Periodicals LLC. LA - English DB - MTMT ER - TY - JOUR AU - Rocha-Gomes, Arthur AU - Escobar Teixeira, Amanda AU - da Silva, Alexandre Alves AU - da Silva, Mariana Muniz AU - Santos, Tatielly Roberta AU - Castro, Tulio Pereira Alvarenga e AU - Lessa, Mayara Rodrigues AU - Villela, Daniel Campos AU - Riul, Tania Regina AU - Leite, Hercules Ribeiro TI - Maternal high-fat diet associated with LPS gestational injection induces hypothalamic inflammation and metabolic disorders in male Wistar rat offspring JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 66 PY - 2024 IS - 2 PG - 12 SN - 0012-1630 DO - 10.1002/dev.22462 UR - https://m2.mtmt.hu/api/publication/34662049 ID - 34662049 LA - English DB - MTMT ER - TY - JOUR AU - Ayala, Kathy AU - Voegtline, Kristin AU - Rutherford, Helena J. V TI - Letter to the Editor: Does fetal movement shape the maternal brain? JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 66 PY - 2024 IS - 2 PG - 3 SN - 0012-1630 DO - 10.1002/dev.22467 UR - https://m2.mtmt.hu/api/publication/34649213 ID - 34649213 LA - English DB - MTMT ER - TY - JOUR AU - Hunter, Sharon K. AU - Hoffman, M. Camille AU - D'Alessandro, Angelo AU - Freedman, Robert TI - Developmental windows for effects of choline and folate on excitatory and inhibitory neurotransmission during human gestation JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 66 PY - 2024 IS - 2 PG - 13 SN - 0012-1630 DO - 10.1002/dev.22453 UR - https://m2.mtmt.hu/api/publication/34611035 ID - 34611035 AB - Choline and folate are critical nutrients for fetal brain development, but the timing of their influence during gestation has not been previously characterized. At different periods during gestation, choline stimulation of alpha 7-nicotinic receptors facilitates the conversion of gamma-aminobutyric acid (GABA) receptors from excitatory to inhibitory and recruitment of GluR1-R2 receptors for faster excitatory responses to glutamate. The outcome of the fetal development of inhibition and excitation was assessed in 159 newborns by P50 cerebral auditory-evoked responses. Paired stimuli, S1 and S2, were presented 500 ms apart. Higher P50 amplitude in response to S1 (P50S1microV) assesses excitation, and lower P50S2microV assesses inhibition in this paired-stimulus paradigm. The development of inhibition was related solely to maternal choline plasma concentration and folate supplementation at 16 weeks' gestation. The development of excitation was related only to maternal choline at 28 weeks. Higher maternal choline concentrations later in gestation did not compensate for earlier lower concentrations. At 4 years of age, increased behavior problems on the Child Behavior Checklist 1.5-5 years were related to both newborn inhibition and excitation. The incomplete development of inhibition and excitation associated with lower choline and folate during relatively brief periods of gestation thus has enduring effects on child development. LA - English DB - MTMT ER - TY - JOUR AU - Manzotti, Andrea AU - Panisi, Cristina AU - Pivotto, Micol AU - Vinciguerra, Federico AU - Benedet, Matteo AU - Brazzoli, Federica AU - Zanni, Silvia AU - Comassi, Alberto AU - Caputo, Sara AU - Cerritelli, Francesco AU - Chiera, Marco TI - An in-depth analysis of the polyvagal theory in light of current findings in neuroscience and clinical research JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 66 PY - 2024 IS - 2 PG - 19 SN - 0012-1630 DO - 10.1002/dev.22450 UR - https://m2.mtmt.hu/api/publication/34594227 ID - 34594227 AB - The polyvagal theory has led to the understanding of the functions of the autonomic nervous system in biological development in humans, since the vagal system, a key structure within the polyvagal theory, plays a significant role in addressing challenges of the mother-child dyad. This article aims to summarize the neurobiological aspects of the polyvagal theory, highlighting some of its strengths and limitations through the lens of new evidence emerging in several research fields-including comparative anatomy, embryology, epigenetics, psychology, and neuroscience-in the 25 years since the theory's inception. Rereading and incorporating the polyvagal idea in light of modern scientific findings helps to interpret the role of the vagus nerve through the temporal dimension (beginning with intrauterine life) and spatial dimension (due to the numerous connections of the vagus with various structures and systems) in the achievement and maintenance of biopsychosocial well-being, from the uterus to adulthood. LA - English DB - MTMT ER - TY - JOUR AU - Jansen, Elena AU - Marceau, Kristine AU - Sellers, Ruth AU - Chen, Tong AU - Garfield, Craig F. AU - Leve, Leslie D. AU - Neiderhiser, Jenae M. AU - Spotts, Erica L. AU - Roary, Mary TI - The role of fathers in child development from preconception to postnatal influences: Opportunities for the National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) program JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 66 PY - 2024 IS - 2 PG - 18 SN - 0012-1630 DO - 10.1002/dev.22451 UR - https://m2.mtmt.hu/api/publication/34593912 ID - 34593912 AB - A growing body of literature highlights the important role of paternal health and socioemotional characteristics in child development, from preconception through adolescence. Much of this research addresses the indirect effects of fathers, for instance, their influence on maternal behaviors during the prenatal period or via the relationship with their partner. However, emerging evidence also recognizes the direct role of paternal health and behavior for child health and adjustment across development. This critical review presents evidence of biological and sociocultural influences of fathers on preconception, prenatal, and postnatal contributions to child development. The National Institutes of Health Environmental influences on Child Health Outcomes (ECHO) program incorporates in its central conceptualization the impact of fathers on family and child outcomes. This critical synthesis of the literature focuses on three specific child outcomes in the ECHO program: health outcomes (e.g., obesity), neurodevelopmental outcomes (e.g., emotional, behavioral, psychopathological development), and positive health. We highlight the unique insights gained from the literature to date and provide next steps for future studies on paternal influences. LA - English DB - MTMT ER - TY - JOUR AU - Oak, Sasha AU - Nguyen, Christine AU - Rodney-Hernandez, Paolaenid AU - Rincon-Cortes, Millie TI - Behavioral responses to natural rewards in developing male and female rats JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 66 PY - 2024 IS - 1 PG - 8 SN - 0012-1630 DO - 10.1002/dev.22448 UR - https://m2.mtmt.hu/api/publication/34627419 ID - 34627419 N1 - Export Date: 28 February 2024; CODEN: DEPBA LA - English DB - MTMT ER - TY - JOUR AU - Bounoua, Nadia AU - Tabachnick, Alexandra R. AU - Eiden, Rina D. AU - Labella, Madelyn H. AU - Dozier, Mary TI - Emotion dysregulation and reward responsiveness as predictors of autonomic reactivity to an infant cry task among substance-using pregnant and postpartum women JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 66 PY - 2024 IS - 1 PG - 9 SN - 0012-1630 DO - 10.1002/dev.22449 UR - https://m2.mtmt.hu/api/publication/34601136 ID - 34601136 AB - Maternal substance use may interfere with optimal parenting, lowering maternal responsiveness during interactions with their children. Previous work has identified maternal autonomic nervous system (ANS) reactivity to parenting-relevant stressors as a promising indicator of real-world parenting behaviors. However, less is known about the extent to which individual differences in emotion dysregulation and reward processing, two mechanisms of substance use, relate to maternal ANS reactivity in substance-using populations. The current study examined associations among emotion dysregulation, reward responsiveness, and ANS reactivity to an infant cry task among 77 low-income and substance-using women who were either pregnant (n = 63) or postpartum (n = 14). Two indicators of ANS functioning were collected during a 9 min computerized infant cry task (Crybaby task): respiratory sinus arrhythmia (RSA) and pre-ejection period. Mothers also completed self-reported measures of emotion dysregulation and reward responsiveness. Analyses revealed that trait emotion regulation was associated with RSA reactivity to the Crybaby task, such that greater emotion dysregulation was associated with greater RSA reduction during the infant cry task than lower emotion dysregulation. Reward responsiveness was not significantly associated with either indicator of ANS reactivity to the task. Findings revealed distinct patterns of associations linking emotion dysregulation with ANS reactivity during a parenting-related computerized task, suggesting that emotion regulation may be a key intervention target for substance-using mothers. LA - English DB - MTMT ER - TY - JOUR AU - Wall, K.M. AU - Penner, F. AU - Dell, J. AU - Lowell, A. AU - Potenza, M.N. AU - Mayes, L.C. AU - Rutherford, H.J.V. TI - Maternal psychological risk and the neural correlates of infant face processing: A latent profile analysis JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 66 PY - 2024 IS - 1 SN - 0012-1630 DO - 10.1002/dev.22445 UR - https://m2.mtmt.hu/api/publication/34510676 ID - 34510676 N1 - Yale Child Study Center, Yale University School of Medicine, New Haven, CT, United States Interdepartmental Neuroscience Program, Yale University, New Haven, CT, United States Department of Psychology, University of South Florida St Petersburg, St. Petersburg, FL, United States Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States Department of Neuroscience, Yale School of Medicine, New Haven, CT, United States The Connecticut Mental Health Center, New Haven, CT, United States The Connecticut Council on Problem Gambling, Wethersfield, CT, United States The Wu Tsai Institute, Yale University, New Haven, CT, United States Export Date: 17 January 2024 CODEN: DEPBA Correspondence Address: Rutherford, H.J.V.; Yale Child Study Center, 230 South Frontage Rd, United States; email: helena.rutherford@yale.edu LA - English DB - MTMT ER - TY - JOUR AU - Myers, A.M. AU - Bowen, S.E. AU - Brummelte, S. TI - Maternal care behavior and physiology moderate offspring outcomes following gestational exposure to opioids JF - DEVELOPMENTAL PSYCHOBIOLOGY J2 - DEV PSYCHOBIOL VL - 65 PY - 2023 IS - 8 PG - 21 SN - 0012-1630 DO - 10.1002/dev.22433 UR - https://m2.mtmt.hu/api/publication/34556707 ID - 34556707 AB - The opioid epidemic has resulted in a drastic increase in gestational exposure to opioids. Opioid-dependent pregnant women are typically prescribed medications for opioid use disorders (“MOUD”; e.g., buprenorphine [BUP]) to mitigate the harmful effects of abused opioids. However, the consequences of exposure to synthetic opioids, particularly BUP, during gestation on fetal neurodevelopment and long-term outcomes are poorly understood. Further, despite the known adverse effects of opioids on maternal care, many preclinical and clinical studies investigating the effects of gestational opioid exposure on offspring outcomes fail to report on maternal care behaviors. Considering that offspring outcomes are heavily dependent upon the quality of maternal care, it is important to evaluate the effects of gestational opioid exposure in the context of the mother−infant dyad. This review compares offspring outcomes after prenatal opioid exposure and after reduced maternal care and integrates this information to potentially identify common underlying mechanisms. We explore whether adverse outcomes after gestational BUP exposure are due to direct effects of opioids in utero, deficits in maternal care, or a combination of both factors. Finally, suggestions for improving preclinical models of prenatal opioid exposure are provided to promote more translational studies that can help to improve clinical outcomes for opioid-dependent mothers. © 2023 Wiley Periodicals LLC. LA - English DB - MTMT ER -