TY - JOUR AU - Fan, W. AU - Chen, J. AU - Cao, Y. AU - Tan, J. AU - Li, J. AU - Wang, S. AU - Jin, P. AU - Song, X. TI - A novel C-type lectin protein (BjCTL5) interacts with apoptosis stimulating proteins of p53 (ASPP) to activate NF-κB signaling pathway in primitive chordate JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 156 PY - 2024 SN - 0145-305X DO - 10.1016/j.dci.2024.105166 UR - https://m2.mtmt.hu/api/publication/34805436 ID - 34805436 N1 - School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, 266109, China Laboratory for Comparative Genomics and Bioinformatics & Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, 210046, China Export Date: 22 April 2024 CODEN: DCIMD Correspondence Address: Song, X.; School of Marine Science and Engineering, China; email: songxiaojun@qau.edu.cn Correspondence Address: Jin, P.; Laboratory for Comparative Genomics and Bioinformatics & Jiangsu Key Laboratory for Biodiversity and Biotechnology, China; email: jinping8312@163.com Chemicals/CAS: mannose, 31103-86-3; polyinosinic polycytidylic acid, 24939-03-5, 26301-44-0 Funding details: National Natural Science Foundation of China, NSFC, 31801969, 31970415 Funding details: National Natural Science Foundation of China, NSFC Funding details: Natural Science Foundation of Shandong Province, ZR2023MC141, 202210435003 Funding details: Natural Science Foundation of Shandong Province Funding text 1: This research was supported by the National Natural Science Foundation of China ( 31801969 and 31970415 ), the Natural Science Foundation of Shandong Province ( ZR2023MC141 ) and the Innovation and Entrepreneurship Training Program for college students ( 202210435003 ). This research was financially supported also by ‘First class fishery discipline’ programme and a special talent programme ‘One Thing One Decision (Yishi Yiyi)’ programme in Shandong Province, China. The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. AB - C-type lectin proteins (CTLs), a group of pattern recognition receptors (PRRs), play pivotal roles in immune responses. However, the signal transduction and regulation of CTLs in cephalochordates have yet to be explored. In this study, we examined the composition of CTLs in Branchiostoma japonicum, identifying a total of 272 CTLs. These CTLs underwent further analysis concerning domain arrangement, tandem and segmental duplication events. A multidomain C-type lectin gene, designated as BjCTL5, encompassing CLECT, KR, CUB, MAM, and SR domains, was the focal point of our investigation. BjCTL5 exhibits ubiquitous expression across all detected tissues and is responsive to stimulation by LPS, mannose, and poly (I:C). The recombinant protein of BjCTL5 can bind to Escherichia coli and Staphylococcus aureus, inducing their agglutination and inhibiting the proliferation of S. aureus. Yeast two-hybrid, CoIP, and confocal immunofluorescence experiments revealed the interaction between BjCTL5 and apoptosis-stimulating proteins of p53, BjASPP. Intriguingly, BjCTL5 was observed to induce the luciferase activity of the NF-κB promoter in HEK293T cells. These results suggested a potential interaction between BjCTL5 and BjASPP, implicating that they involve in the activation of the NF-κB signaling pathway, which provides an evolutionary viewpoint on NF-κB signaling pathway in primitive chordate. © 2024 Elsevier Ltd LA - English DB - MTMT ER - TY - JOUR AU - Melepat, Balraj AU - Li, Tao AU - Vinkler, Michal TI - Natural selection directing molecular evolution in vertebrate viral sensors JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 154 PY - 2024 SN - 0145-305X DO - 10.1016/j.dci.2024.105147 UR - https://m2.mtmt.hu/api/publication/34799243 ID - 34799243 LA - English DB - MTMT ER - TY - JOUR AU - Felipo-Benavent, Mar AU - O'Connor, Jose-Enrique AU - Alvaro-Alvarez, Teresa AU - Valls-Torres, Monica AU - Rojo, Carlos AU - Garcia-Parraga, Daniel AU - Martinez-Romero, Alicia AU - Rubio-Guerri, Consuelo TI - Monitoring platelet function in marine mammals: Intracellular Ca2+ mobilization as a biomarker of platelet activation JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 150 PY - 2024 PG - 13 SN - 0145-305X DO - 10.1016/j.dci.2023.105080 UR - https://m2.mtmt.hu/api/publication/34640819 ID - 34640819 LA - English DB - MTMT ER - TY - JOUR AU - Boidin-Wichlacz, Celine AU - Andersen, Ann C. AU - Jouy, Nathalie AU - Hourdez, Stephane AU - Tasiemski, Aurelie TI - A single coelomic cell type is involved in both immune and respiratory functions of the coastal bioindicator annelid: Capitella C-Channel1 from the English Channel JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 153 PY - 2024 PG - 16 SN - 0145-305X DO - 10.1016/j.dci.2024.105132 UR - https://m2.mtmt.hu/api/publication/34630130 ID - 34630130 N1 - Export Date: 28 February 2024; CODEN: DCIMD LA - English DB - MTMT ER - TY - JOUR AU - Mushtaq, Zahoor AU - Prasad, Kurcheti Pani AU - Jeena, K. AU - Gireesh-Babu, P. TI - Short peptidoglycan recognition protein 5 modulates immune response to bacteria in Indian major carp, Cirrhinus mrigala JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 152 PY - 2024 PG - 11 SN - 0145-305X DO - 10.1016/j.dci.2023.105104 UR - https://m2.mtmt.hu/api/publication/34627055 ID - 34627055 LA - English DB - MTMT ER - TY - JOUR AU - Huang, Yu AU - Wang, Tan AU - Jiang, Chun AU - Li, Shengjie AU - Zhou, Hongjian AU - Li, Ruimin TI - Relish-facilitated lncRNA-CR11538 suppresses Drosophila Imd immune response and maintains immune homeostasis via decoying Relish away from antimicrobial peptide promoters JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 151 PY - 2024 PG - 12 SN - 0145-305X DO - 10.1016/j.dci.2023.105098 UR - https://m2.mtmt.hu/api/publication/34597478 ID - 34597478 AB - Innate immunity plays a crucial role in host defense against pathogen invasion and its strength and duration requires precise control. Long non-coding RNAs (lncRNAs) have become important regulators of innate immunity, yet their roles in Drosophila immune responses remain largely unknown. In this study, we identified that the overexpression of lncRNA-CR11538 inhibits the expression of antimicrobial peptides (AMPs) Dpt and AttA in Drosophila upon Escherichia coli (E. coli) infection, and influences the survival rate of flies after E. cloacae infection. Mechanically, lncRNA-CR11538 decoys Relish away from AMPs promoter region. We further revealed that Relish can promote the transcription of lncRNA-CR11538. After analyzing the dynamic expression profile of lncRNA-CR11538 during Imd immune response, we put forward a hypothesis that in the late stage of Imd immune response, lncRNA-CR11538 can be activated by Relish and further decoy Relish away from the AMPs promoter to suppress excessive immune signal and maintain immune homeostasis. This mechanism we proposed provides insights into the complex regulatory networks controlling immune responses in Drosophila and suggests potential targets for therapeutic intervention in diseases involving dysregulated immune responses. LA - English DB - MTMT ER - TY - JOUR AU - Zeinali, Safieh AU - Sutton, Kate AU - Vervelde, Lonneke TI - Distribution and spatiotemporal development of organised lymphoid tissues in the chicken intestinal tract JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 151 PY - 2024 PG - 8 SN - 0145-305X DO - 10.1016/j.dci.2023.105096 UR - https://m2.mtmt.hu/api/publication/34593130 ID - 34593130 AB - Chickens exhibit a distinct immune architecture characterised by the absence of draining lymph nodes and the presence of a well-developed mucosa-associated lymphoid tissue. The structure and spatiotemporal development of chicken lymphoid tissues in the intestine are poorly documented. The macroscopically indistinct structure of chicken Peyer's patches has impeded studies into their development. The generation of CSF1R-eGFP reporter transgenic chickens enables visualisation of the development, organisation and extent of chicken lymphoid tissues by unique macroscopic views. CSF1R-eGFP reporter transgenic chickens were used to investigate the distribution and spatiotemporal development of PP and caecal tonsils in embryonic day 18 to 8-week-old chickens. Peyer's patch anlagen are present at ED18 with a similar frequency and distribution pattern observed in 2- and 8week-old chickens. These findings can support in ovo and post-hatch mucosal vaccination strategies and the development of vaccine delivery systems targeted to the specialized epithelium overlying the Peyer's patches. LA - English DB - MTMT ER - TY - JOUR AU - Niemand, Rikus R. AU - Stafford, James L. TI - Counteracting immunotyrosine-based signaling motifs augment zebrafish leukocyte immune-type receptor-mediated phagocytic activity JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 153 PY - 2024 PG - 18 SN - 0145-305X DO - 10.1016/j.dci.2023.105121 UR - https://m2.mtmt.hu/api/publication/34581806 ID - 34581806 AB - Leukocyte immune-type receptors (LITRs) represent a polymorphic and polygenic family of immunoregulatory proteins originally discovered in channel catfish (Ictalurus punctatus; IpLITRs). Belonging to the immunoglobulin superfamily (IgSF), IpLITRs are generally classified as stimulatory or inhibitory types based on their utilization of various intracellular tyrosine-based signaling motifs. While research has shown that IpLITRs can activate as well as abrogate different immune cell effector responses including phagocytosis, recent identification of LITRs within the zebrafish genome (Danio rerio; DrLITRs) revealed the existence of fish LITR-types uniquely containing counteracting stimulatory and inhibitory cytoplasmic tail (CYT) region motifs (i.e., an immunoreceptor tyrosinebased activation motif; ITAM, and immunoreceptor tyrosine-based inhibitory motif; ITIM) within the same receptor. This arrangement is unusual as these motifs typically exist on separate stimulatory (i.e., ITAMcontaining) or inhibitory (i.e., ITIM-containing) immunoregulatory receptors that then co-engage to fine-tune cellular signaling and effector responses. Using a flow cytometric-based phagocytosis assay, we show here that engagement of DrLITR 1.2-expressing cells with antibody coated 4.5 mu m beads causes a robust ITAMdependent phagocytic response and reveal that its tandem ITIM motif surprisingly enhances the DrLITR 1.2induced phagocytic activity while simultaneously decreasing the receptors ability to bind the beads. Confocal microscopy studies also revealed that the ITIM-associated inhibitory signaling molecule SHP-2 is localized to the phagocytic synapse during the phagocytic response. Overall, these results provide the first functional characterization of teleost immune receptors containing a tandem ITAM and ITIM and allow for the proposal of an intracytoplasmic tail signaling model for ITIM-mediated enhancement of ITAM-dependent cellular activation. LA - English DB - MTMT ER - TY - JOUR AU - Kuttiyarthu, Veetil N. AU - Cedraz, de Oliveira H. AU - Gomez-Samblas, M. AU - Divín, D. AU - Melepat, B. AU - Voukali, E. AU - Świderská, Z. AU - Krajzingrová, T. AU - Těšický, M. AU - Jung, F. AU - Beneš, V. AU - Madsen, O. AU - Vinkler, M. TI - Peripheral inflammation-induced changes in songbird brain gene expression: 3’ mRNA transcriptomic approach JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 151 PY - 2024 SN - 0145-305X DO - 10.1016/j.dci.2023.105106 UR - https://m2.mtmt.hu/api/publication/34559175 ID - 34559175 N1 - Charles University, Faculty of Science, Department of Zoology, Viničná 7, Prague, 128 43, Czech Republic Wageningen University and Research, Department of Animal Sciences, Animal Breeding and Genomics, Droevendaalsesteeg 1, Wageningen, 6708PB, Netherlands Federal University of Viçosa, MG, Viçosa, 36570-900, Brazil Granada University, Science faculty, Department of Parasitology, Granada, Granada, CP:18071, Spain EMBL, Genomics Core Facility, Meyerhofstraße 1, Heidelberg, 69117, Germany Export Date: 6 February 2024 CODEN: DCIMD Correspondence Address: Vinkler, M.; Charles University, Viničná 7, Czech Republic; email: michal.vinkler@natur.cuni.cz LA - English DB - MTMT ER - TY - JOUR AU - Jin, H. AU - Tu, M. AU - Meng, Z. AU - Jiang, B. AU - Yang, Q. AU - Li, Y. AU - Zhang, Z. TI - Identification and structural analysis of dimeric chicken complement component 3d and its binding with chicken complement receptor 2 JF - DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY J2 - DEV COMP IMMUNOL VL - 152 PY - 2024 SN - 0145-305X DO - 10.1016/j.dci.2023.105109 UR - https://m2.mtmt.hu/api/publication/34551573 ID - 34551573 N1 - Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China Animal Science and Technology College, Beijing University of Agriculture, Beijing, China Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China Export Date: 1 February 2024 CODEN: DCIMD Correspondence Address: Li, Y.; Institute of Animal Husbandry and Veterinary Medicine, China; email: chunyudady@sina.com Correspondence Address: Zhang, Z.; Institute of Animal Husbandry and Veterinary Medicine, China; email: zhangzhenhua304@163.com LA - English DB - MTMT ER -