@article{MTMT:34805436,
	title = {A novel C-type lectin protein (BjCTL5) interacts with apoptosis stimulating proteins of p53 (ASPP) to activate NF-κB signaling pathway in primitive chordate},
	url = {https://m2.mtmt.hu/api/publication/34805436},
	author = {Fan, W. and Chen, J. and Cao, Y. and Tan, J. and Li, J. and Wang, S. and Jin, P. and Song, X.},
	doi = {10.1016/j.dci.2024.105166},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {156},
	unique-id = {34805436},
	issn = {0145-305X},
	abstract = {C-type lectin proteins (CTLs), a group of pattern recognition receptors (PRRs), play pivotal roles in immune responses. However, the signal transduction and regulation of CTLs in cephalochordates have yet to be explored. In this study, we examined the composition of CTLs in Branchiostoma japonicum, identifying a total of 272 CTLs. These CTLs underwent further analysis concerning domain arrangement, tandem and segmental duplication events. A multidomain C-type lectin gene, designated as BjCTL5, encompassing CLECT, KR, CUB, MAM, and SR domains, was the focal point of our investigation. BjCTL5 exhibits ubiquitous expression across all detected tissues and is responsive to stimulation by LPS, mannose, and poly (I:C). The recombinant protein of BjCTL5 can bind to Escherichia coli and Staphylococcus aureus, inducing their agglutination and inhibiting the proliferation of S. aureus. Yeast two-hybrid, CoIP, and confocal immunofluorescence experiments revealed the interaction between BjCTL5 and apoptosis-stimulating proteins of p53, BjASPP. Intriguingly, BjCTL5 was observed to induce the luciferase activity of the NF-κB promoter in HEK293T cells. These results suggested a potential interaction between BjCTL5 and BjASPP, implicating that they involve in the activation of the NF-κB signaling pathway, which provides an evolutionary viewpoint on NF-κB signaling pathway in primitive chordate. © 2024 Elsevier Ltd},
	keywords = {GENE; APOPTOSIS; ARTICLE; signal transduction; LIPOPOLYSACCHARIDE; C-TYPE LECTIN; human; protein analysis; Escherichia coli; innate immunity; controlled study; nonhuman; enzyme activity; Gene Expression; human cell; unclassified drug; mannose; lectin; immunofluorescence; protein domain; protein protein interaction; Staphylococcus aureus; immunoglobulin enhancer binding protein; NF-κB; protein interaction; protein p53; Chordata; polyinosinic polycytidylic acid; Pattern recognition receptors; HEK293T cell line; amphioxus; ASPP; NF kB signaling; BjCTL5 protein},
	year = {2024},
	eissn = {1879-0089}
}

@article{MTMT:34799243,
	title = {Natural selection directing molecular evolution in vertebrate viral sensors},
	url = {https://m2.mtmt.hu/api/publication/34799243},
	author = {Melepat, Balraj and Li, Tao and Vinkler, Michal},
	doi = {10.1016/j.dci.2024.105147},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {154},
	unique-id = {34799243},
	issn = {0145-305X},
	year = {2024},
	eissn = {1879-0089},
	orcid-numbers = {Vinkler, Michal/0000-0003-3572-9494}
}

@article{MTMT:34640819,
	title = {Monitoring platelet function in marine mammals: Intracellular Ca<SUP>2+</SUP> mobilization as a biomarker of platelet activation},
	url = {https://m2.mtmt.hu/api/publication/34640819},
	author = {Felipo-Benavent, Mar and O'Connor, Jose-Enrique and Alvaro-Alvarez, Teresa and Valls-Torres, Monica and Rojo, Carlos and Garcia-Parraga, Daniel and Martinez-Romero, Alicia and Rubio-Guerri, Consuelo},
	doi = {10.1016/j.dci.2023.105080},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {150},
	unique-id = {34640819},
	issn = {0145-305X},
	keywords = {Flow Cytometry; platelet; ADP; Pinnipeds; Cetaceans; haemostasia; Fluo-4 AM},
	year = {2024},
	eissn = {1879-0089},
	orcid-numbers = {Rubio-Guerri, Consuelo/0000-0001-9001-0437}
}

@article{MTMT:34630130,
	title = {A single coelomic cell type is involved in both immune and respiratory functions of the coastal bioindicator annelid: Capitella C-Channel1 from the English Channel},
	url = {https://m2.mtmt.hu/api/publication/34630130},
	author = {Boidin-Wichlacz, Celine and Andersen, Ann C. and Jouy, Nathalie and Hourdez, Stephane and Tasiemski, Aurelie},
	doi = {10.1016/j.dci.2024.105132},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {153},
	unique-id = {34630130},
	issn = {0145-305X},
	keywords = {ERYTHROCYTES; Antimicrobial peptide; Immune function; globin; Capitella capitata},
	year = {2024},
	eissn = {1879-0089},
	orcid-numbers = {Tasiemski, Aurelie/0000-0003-3559-5115}
}

@article{MTMT:34627055,
	title = {Short peptidoglycan recognition protein 5 modulates immune response to bacteria in Indian major carp, Cirrhinus mrigala},
	url = {https://m2.mtmt.hu/api/publication/34627055},
	author = {Mushtaq, Zahoor and Prasad, Kurcheti Pani and Jeena, K. and Gireesh-Babu, P.},
	doi = {10.1016/j.dci.2023.105104},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {152},
	unique-id = {34627055},
	issn = {0145-305X},
	keywords = {Aeromonas hydrophila; Innate immune response; PGRP; Cirrhinus mrigala; Amidase activity},
	year = {2024},
	eissn = {1879-0089}
}

@article{MTMT:34597478,
	title = {Relish-facilitated lncRNA-CR11538 suppresses Drosophila Imd immune response and maintains immune homeostasis via decoying Relish away from antimicrobial peptide promoters},
	url = {https://m2.mtmt.hu/api/publication/34597478},
	author = {Huang, Yu and Wang, Tan and Jiang, Chun and Li, Shengjie and Zhou, Hongjian and Li, Ruimin},
	doi = {10.1016/j.dci.2023.105098},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {151},
	unique-id = {34597478},
	issn = {0145-305X},
	abstract = {Innate immunity plays a crucial role in host defense against pathogen invasion and its strength and duration requires precise control. Long non-coding RNAs (lncRNAs) have become important regulators of innate immunity, yet their roles in Drosophila immune responses remain largely unknown. In this study, we identified that the overexpression of lncRNA-CR11538 inhibits the expression of antimicrobial peptides (AMPs) Dpt and AttA in Drosophila upon Escherichia coli (E. coli) infection, and influences the survival rate of flies after E. cloacae infection. Mechanically, lncRNA-CR11538 decoys Relish away from AMPs promoter region. We further revealed that Relish can promote the transcription of lncRNA-CR11538. After analyzing the dynamic expression profile of lncRNA-CR11538 during Imd immune response, we put forward a hypothesis that in the late stage of Imd immune response, lncRNA-CR11538 can be activated by Relish and further decoy Relish away from the AMPs promoter to suppress excessive immune signal and maintain immune homeostasis. This mechanism we proposed provides insights into the complex regulatory networks controlling immune responses in Drosophila and suggests potential targets for therapeutic intervention in diseases involving dysregulated immune responses.},
	keywords = {Drosophila melanogaster; transcription regulation; Relish; lncRNA-CR11538; Imd immune response},
	year = {2024},
	eissn = {1879-0089},
	orcid-numbers = {Zhou, Hongjian/0000-0002-5397-9879}
}

@article{MTMT:34593130,
	title = {Distribution and spatiotemporal development of organised lymphoid tissues in the chicken intestinal tract},
	url = {https://m2.mtmt.hu/api/publication/34593130},
	author = {Zeinali, Safieh and Sutton, Kate and Vervelde, Lonneke},
	doi = {10.1016/j.dci.2023.105096},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {151},
	unique-id = {34593130},
	issn = {0145-305X},
	abstract = {Chickens exhibit a distinct immune architecture characterised by the absence of draining lymph nodes and the presence of a well-developed mucosa-associated lymphoid tissue. The structure and spatiotemporal development of chicken lymphoid tissues in the intestine are poorly documented. The macroscopically indistinct structure of chicken Peyer's patches has impeded studies into their development. The generation of CSF1R-eGFP reporter transgenic chickens enables visualisation of the development, organisation and extent of chicken lymphoid tissues by unique macroscopic views. CSF1R-eGFP reporter transgenic chickens were used to investigate the distribution and spatiotemporal development of PP and caecal tonsils in embryonic day 18 to 8-week-old chickens. Peyer's patch anlagen are present at ED18 with a similar frequency and distribution pattern observed in 2- and 8week-old chickens. These findings can support in ovo and post-hatch mucosal vaccination strategies and the development of vaccine delivery systems targeted to the specialized epithelium overlying the Peyer's patches.},
	keywords = {INTESTINE; ontogeny; chicken; CSF1R; transgenic chicken; Peyer 's patches},
	year = {2024},
	eissn = {1879-0089},
	orcid-numbers = {Vervelde, Lonneke/0000-0003-2241-1743}
}

@article{MTMT:34581806,
	title = {Counteracting immunotyrosine-based signaling motifs augment zebrafish leukocyte immune-type receptor-mediated phagocytic activity},
	url = {https://m2.mtmt.hu/api/publication/34581806},
	author = {Niemand, Rikus R. and Stafford, James L.},
	doi = {10.1016/j.dci.2023.105121},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {153},
	unique-id = {34581806},
	issn = {0145-305X},
	abstract = {Leukocyte immune-type receptors (LITRs) represent a polymorphic and polygenic family of immunoregulatory proteins originally discovered in channel catfish (Ictalurus punctatus; IpLITRs). Belonging to the immunoglobulin superfamily (IgSF), IpLITRs are generally classified as stimulatory or inhibitory types based on their utilization of various intracellular tyrosine-based signaling motifs. While research has shown that IpLITRs can activate as well as abrogate different immune cell effector responses including phagocytosis, recent identification of LITRs within the zebrafish genome (Danio rerio; DrLITRs) revealed the existence of fish LITR-types uniquely containing counteracting stimulatory and inhibitory cytoplasmic tail (CYT) region motifs (i.e., an immunoreceptor tyrosinebased activation motif; ITAM, and immunoreceptor tyrosine-based inhibitory motif; ITIM) within the same receptor. This arrangement is unusual as these motifs typically exist on separate stimulatory (i.e., ITAMcontaining) or inhibitory (i.e., ITIM-containing) immunoregulatory receptors that then co-engage to fine-tune cellular signaling and effector responses. Using a flow cytometric-based phagocytosis assay, we show here that engagement of DrLITR 1.2-expressing cells with antibody coated 4.5 mu m beads causes a robust ITAMdependent phagocytic response and reveal that its tandem ITIM motif surprisingly enhances the DrLITR 1.2induced phagocytic activity while simultaneously decreasing the receptors ability to bind the beads. Confocal microscopy studies also revealed that the ITIM-associated inhibitory signaling molecule SHP-2 is localized to the phagocytic synapse during the phagocytic response. Overall, these results provide the first functional characterization of teleost immune receptors containing a tandem ITAM and ITIM and allow for the proposal of an intracytoplasmic tail signaling model for ITIM-mediated enhancement of ITAM-dependent cellular activation.},
	keywords = {PHAGOCYTOSIS; innate immunity; fish; Flow Cytometry; intracellular signaling; Immunoregulatory receptors},
	year = {2024},
	eissn = {1879-0089}
}

@article{MTMT:34559175,
	title = {Peripheral inflammation-induced changes in songbird brain gene expression: 3’ mRNA transcriptomic approach},
	url = {https://m2.mtmt.hu/api/publication/34559175},
	author = {Kuttiyarthu, Veetil N. and Cedraz, de Oliveira H. and Gomez-Samblas, M. and Divín, D. and Melepat, B. and Voukali, E. and Świderská, Z. and Krajzingrová, T. and Těšický, M. and Jung, F. and Beneš, V. and Madsen, O. and Vinkler, M.},
	doi = {10.1016/j.dci.2023.105106},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {151},
	unique-id = {34559175},
	issn = {0145-305X},
	year = {2024},
	eissn = {1879-0089}
}

@article{MTMT:34551573,
	title = {Identification and structural analysis of dimeric chicken complement component 3d and its binding with chicken complement receptor 2},
	url = {https://m2.mtmt.hu/api/publication/34551573},
	author = {Jin, H. and Tu, M. and Meng, Z. and Jiang, B. and Yang, Q. and Li, Y. and Zhang, Z.},
	doi = {10.1016/j.dci.2023.105109},
	journal-iso = {DEV COMP IMMUNOL},
	journal = {DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY},
	volume = {152},
	unique-id = {34551573},
	issn = {0145-305X},
	year = {2024},
	eissn = {1879-0089}
}