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    &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 37097152&lt;/span&gt;
    | &lt;span class=&quot;status-data status-APPROVED&quot;&gt; 	Nyilvános
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.04.29. 12:32 Szabad Viktória (SE_EKK_Admin5_SZV, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Funding Agency and Grant Number: Deanship of Scientific Research at Northern Border University [NBU-FFR-2026-3770-XX]
            Funding text: Deanship of Scientific Research at Northern Border University, project number NBU-FFR-2026-3770-XX.&lt;/pre&gt;

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            Funding text: This study was supported by the 2022 Provincial Key Clinical Specialty Construction Funds (Award Number: KZSJZ010 Recipient: Xiaoming Wang), and the 2023 Natural Science Research Project of Anhui Province Universities (Award Number: 2023AH040254 Recipient: Xiaoming Wang).</comment>
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            2026.02.04. 16:17
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.02.04. 16:13 Sonnevend Kinga (SE_AOK_Adm5_Élet_kutcsop, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Funding Agency and Grant Number: Provincial Key Clinical Specialty Construction Funds [KZSJZ010]; Natural Science Research Project of Anhui Province Universities [2023AH040254]
            Funding text: This study was supported by the 2022 Provincial Key Clinical Specialty Construction Funds (Award Number: KZSJZ010 Recipient: Xiaoming Wang), and the 2023 Natural Science Research Project of Anhu...&lt;/pre&gt;
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            2026.02.04. 16:17
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Export Date: 04 February 2026; Cited By: 0; Correspondence Address: X. Wang; Department of Hepatobiliary Surgery, The First Afliated Hospital of Wannan Medical College, Wuhu, Anhui, China; email: wxm6901@126.com; CODEN: OMPEA;&lt;/pre&gt;
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            Funding text: This study was supported by grants from the Hubei Provincial Natural Science Foundation of China (No. 2023AFB825) and Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (No. 2023A15).</comment>
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.05.13. 22:46 Szuper Admin (admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Funding Agency and Grant Number: Hubei Provincial Natural Science Foundation of China [2023AFB825]; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology [2023A15]
            Funding text: This study was supported by grants from the Hubei Provincial Natural Science Foundation of China (No. 2023AFB825) and Tongji Hospital, Tongji Medical College, Huazhong Univer...&lt;/pre&gt;

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            Funding text: Study on the Relationship between Wheezing Disorders in Children and Immune Cell Infiltration, Microbiota, and Inflammatory Cytokine Expression. Xiangtan Science and Technology Bureau, SF-YB20240016.</comment>
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      <title>Frequencies of PD-1 and LAG-3 positive T cells in asthmatic children and their relationship with inflammatory cytokines</title>
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      <abstractText>Objectives This study aimed to investigate the expression of programmed cell death protein 1 (PD-1) and lymphocyte-activation gene 3 (LAG-3) on CD4+ and CD8+ T cells in children with asthma and their relationship with Th2-associated inflammatory cytokines (IL-4, IL-5, and IL-13). The goal was to elucidate the potential roles of these immune checkpoint molecules in asthma pathogenesis and severity.Methods A prospective observational study was conducted involving 112 asthmatic children aged 5-15 years and 100 healthy controls. Peripheral blood mononuclear cells (PBMCs) were isolated, and flow cytometry was used to analyze the frequencies of PD-1+ and LAG-3+ T cells. Serum levels of IL-4, IL-5, and IL-13 were measured using ELISA. Asthma severity was classified according to the Global Initiative for Asthma (GINA) guidelines, and demographic, clinical, and lung function data were collected. Statistical analyses included Pearson correlation, ROC curve analysis, and logistic regression to assess the diagnostic and prognostic value of PD-1 and LAG-3 expression.Results Asthmatic children, particularly those with moderate-to-severe disease, exhibited significantly higher frequencies of PD-1+ and LAG-3+ T cells compared to healthy controls. Serum levels of IL-4, IL-5, and IL-13 were also elevated in asthmatic children, with the highest levels observed in moderate-to-severe cases. The frequencies of PD-1+LAG-3+ T cells were positively correlated with IL-13 levels and negatively correlated with lung function parameters, including FVC%, FEV1%, and PEF%. ROC curve analysis demonstrated that CD4+PD-1+LAG-3+ T cells had superior diagnostic performance for moderate-to-severe asthma. Logistic regression identified CD4+LAG-3+PD-1+, and IL-13 as independent risk factors for moderate-to-severe asthma.Conclusions The elevated frequencies of PD-1 and LAG-3 on T cells in asthmatic children, particularly in those with moderate-to-severe disease, suggested that these immune checkpoint molecules play a critical role in asthma pathogenesis and severity. These findings highlighted the potential of PD-1 and LAG-3 as biomarkers for asthma severity and therapeutic targets, offering new avenues for immune modulation in pediatric asthma management.</abstractText>
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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.04.28. 14:43 Fi Tamás (SE_AOK_Pulmonologia_Admin5_FT, admin)
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Funding Agency and Grant Number: Xiangtan Science and Technology Bureau [SF-YB20240016]
            Funding text: Study on the Relationship between Wheezing Disorders in Children and Immune Cell Infiltration, Microbiota, and Inflammatory Cytokine Expression. Xiangtan Science and Technology Bureau, SF-YB20240016.&lt;/pre&gt;
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            Funding text: : This research was supported by the Zhejiang Provincial Natural Science Foundation of China under Grant No. LTGY23H200002.</comment>
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	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Funding Agency and Grant Number: Zhejiang Provincial Natural Science Foundation of China [LTGY23H200002]
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      <comment>Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Sichuan, Chengdu, China            
            Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Sichuan, Chengdu, China            
            Export Date: 24 February 2025            
            CODEN: OMPEA            
            Correspondence Address: Xie, C.; Department of Obstetrics and Gynecology, Sichuan, China; email: xiechuan85@163.com</comment>
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&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;35783648&quot; target=&quot;_blank&quot;&gt;Unveiling novel biomarkers for platinum chemoresistance in ovarian cancer&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;OPEN MEDICINE&lt;/span&gt;

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&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.02.04. 16:13 Sonnevend Kinga (SE_AOK_Adm5_Élet_kutcsop, admin)
&lt;/div&gt;




	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Sichuan, Chengdu, China            
            Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Sichuan, Chengdu, China            
            Export Date: 24 February 2025            
            CODEN: OMPEA            
  ...&lt;/pre&gt;

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