TY - JOUR AU - Truong, Thi Thuy AU - Singh, Alka Ashok AU - Bang, Nguyen Van AU - Vu, Nguyen Minh Hung AU - Na, Sungsoo AU - Choi, Jaeyeop AU - Oh, Junghwan AU - Mondal, Sudip TI - Mitochondria-Associated Membrane Dysfunction in Neurodegeneration and Its Effects on Lipid Metabolism, Calcium Signaling, and Cell Fate JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 9 SP - 263 SN - 2077-0375 DO - 10.3390/membranes15090263 UR - https://m2.mtmt.hu/api/publication/36325330 ID - 36325330 AB - Mitochondria-associated membranes (MAMs) are essential for cellular homeostasis. MAMs are specialized contact sites located between the endoplasmic reticulum (ER) and mitochondria and control apoptotic pathways, lipid metabolism, autophagy initiation, and calcium signaling, processes critical to the survival and function of neurons. Although this area of membrane biology remains understudied, increasing evidence links MAM dysfunction to the etiology of major neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS). MAMs consist of a network of protein complexes that mediate molecular exchange and ER–mitochondria tethering. MAMs regulate lipid flow in the brain, including phosphatidylserine and cholesterol; disruption of this process causes membrane instability and impaired synaptic function. Inositol 1,4,5-trisphosphate receptor—voltage-dependent anion channel 1 (IP3R-VDAC1) interactions at MAMs maintain calcium homeostasis, which is required for mitochondria to produce ATP; dysregulation promotes oxidative stress and neuronal death. An effective therapeutic approach for altering neurodegenerative processes is to restore the functional integrity of MAMs. Improving cell-to-cell interactions and modulating MAM-associated proteins may contribute to the restoration of calcium homeostasis and lipid metabolism, both of which are key for neuronal protection. MAMs significantly contribute to the progression of neurodegenerative diseases, making them promising targets for future therapeutic research. This review emphasizes the increasing importance of MAMs in the study of neurodegeneration and their potential as novel targets for membrane-based therapeutic interventions. LA - English DB - MTMT ER - TY - JOUR AU - Al- Mashhadani, Manhal Hameed Ibrahim AU - Szijjártó, Gábor AU - Selim, Asmaa Khaled Mohamed AU - Sebestyén, Zoltán AU - Mihály, Judith AU - Tompos, András TI - Fluorine-Free Membranes Consisting of a Blend of S-PVA and PEBAX 1657 for Proton Exchange Membrane Fuel Cells: The Role of Titanium Dioxide Phosphate (TiO2PO4) Nanoparticle Fillers JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 9 PG - 19 SN - 2077-0375 DO - 10.3390/membranes15090280 UR - https://m2.mtmt.hu/api/publication/36342591 ID - 36342591 AB - Novel blend membranes containing S-PVA and PEBAX 1657 at a blend ratio of 8:2 were doped with varying amounts of titanium dioxide phosphate (TiO2PO4) as a nanoparticle filler at concentrations of 0, 3, 5, and 7 wt%. The membranes were fabricated using the solution-casting technique. The effect of the TiO2PO4 nanofiller on the polymer matrix was thoroughly investigated. Our aim was to investigate how the incorporation of TiO2PO4 nanofillers into non-fluorinated SPP-based membranes affects their structural, physicochemical, and electrochemical properties for application in fuel cells. Crystallinity of the samples was checked by means of X-ray diffraction (XRD), while FTIR was used to investigate the contact between the nanofiller and the polymers. The good compatibility resulted in strong interactions between the constituents and led to increased crystallinity of the membrane as well. Furthermore, SEM images confirmed the uniform distribution of the nanofiller. These structural features led to good thermal stability, as evidenced by thermogravimetric analysis (TGA), and good mechanical strength, as proved by tensile tests. Among the samples investigated, the highest water uptake of 51.70% was achieved on the composite membrane containing 3 wt% TiO2PO4, which also showed the highest ion exchange capacity at room temperature, reaching 1.13 meq/g. In line with these properties, among the synthesized membranes, the membrane labeled SPP 3% TiO2PO4 has the highest current density and power density, with values of 175.5 mA/cm2 and 61.52 mW/cm2, respectively. LA - English DB - MTMT ER - TY - JOUR AU - Mizogami, Maki AU - Iida, Hiroki AU - Tsuchiya, Hironori TI - Lipid Raft Membrane Interactivity Correlating with Cyclooxygenase-2 Selectivity of Non-Steroidal Anti-Inflammatory Drugs JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 9 PG - 15 SN - 2077-0375 DO - 10.3390/membranes15090284 UR - https://m2.mtmt.hu/api/publication/36385129 ID - 36385129 AB - The primary mechanism of non-steroidal anti-inflammatory drugs (NSAIDs) is inhibition of prostaglandin production mediated by cyclooxygenase. Given the possible association of cyclooxygenase-2, but not cyclooxygenase-1, with membrane lipid rafts, we assessed whether the lipid raft membrane interactivity of NSAIDs correlates with cyclooxygenase-2 selectivity. Lipid raft model membranes and reference membranes were prepared with 1,2-dioleoylphosphatidylcholine/sphingomyelin/cholesterol and 1,2-dipalmitoylphosphatidylcholine, respectively. After treating the membranes with 2–50 μM NSAIDs at pH 7.4, 6.5, and 5.5, fluorescence polarization was measured to determine their membrane interactivity. Conventional NSAIDs (diclofenac, ibuprofen, indomethacin, aspirin, and flurbiprofen) and Coxibs (lumiracoxib, etoricoxib, celecoxib, valdecoxib, and rofecoxib) decreased membrane fluidity, whereas Oxicams (meloxicam, piroxicam, tenoxicam, and lornoxicam) increased. Membrane effects of NSAIDs were so dependent on medium pH that they significantly increased with reducing pH from 7.4 to 5.5. Under inflammatory acidic conditions, the lipid raft membrane interactivity of NSAIDs was more likely to correlate with cyclooxygenase-2 selectivity than the reference membrane interactivity. It is hypothesized that NSAIDs may interact with lipid raft membranes to induce membrane fluidity changes with the potency corresponding to cyclooxygenase-2 inhibition, disrupting the structural and functional integrity of lipid rafts to affect the activity of cyclooxygenase-2 localized in lipid rafts, resulting in cyclooxygenase-2 selective inhibition. LA - English DB - MTMT ER - TY - JOUR AU - Monsefi, Estakhrposhti Seyyed Hossein AU - Xu, Jingjing AU - Gfoehler, Margit AU - Harasek, Michael TI - A Validated CFD Model for Gas Exchange in Hollow Fiber Membrane Oxygenators: Incorporating the Bohr and Haldane Effects JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 9 PG - 21 SN - 2077-0375 DO - 10.3390/membranes15090268 UR - https://m2.mtmt.hu/api/publication/36408491 ID - 36408491 N1 - Funding Agency and Grant Number: European Union's Horizon Europe research and innovation programme; [Ndegrees 101130006] Funding text: This research was funded by the European Union's Horizon Europe research and innovation programme under grant number N degrees 101130006. AB - Chronic respiratory diseases claim nearly four million lives annually, making them the third leading cause of death worldwide. Extracorporeal membrane oxygenation (ECMO) is often the last line of support for patients with severe lung failure. Still, its performance is limited by an incomplete understanding of gas exchange in hollow fiber membrane (HFM) oxygenators. Computational fluid dynamics (CFD) has become a robust oxygenator design and optimization tool. However, most models oversimplify O2 and CO2 transport by ignoring their physiological coupling, instead relying on fixed saturation curves or constant-content assumptions. For the first time, this study introduces a novel physiologically informed CFD model that integrates the Bohr and Haldane effects to capture the coupled transport of oxygen and carbon dioxide as functions of local pH, temperature, and gas partial pressures. The model is validated against in vitro experimental data from the literature and assessed against established CFD models. The proposed CFD model achieved excellent agreement with experiments across blood flow rates (100-500 mL/min ), with relative errors below 5% for oxygen and 10-15% for carbon dioxide transfer. These results surpassed the accuracy of all existing CFD approaches, demonstrating that a carefully formulated single-phase model combined with physiologically informed diffusivities can outperform more complex multiphase simulations. This work provides a computationally efficient and physiologically realistic framework for oxygenator optimization, potentially accelerating device development, reducing reliance on costly in vitro testing, and enabling patient-specific simulations. LA - English DB - MTMT ER - TY - JOUR AU - Zhou, Jingwen AU - Wang, Longjun AU - Liu, Hong AU - Li, Xinhao AU - Li, Dalong AU - Yan, Linlin AU - Cheng, Xiquan TI - Recent Progress on the Development of Polyetheretherketone Membranes for Water Remediation JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 9 PG - 24 SN - 2077-0375 DO - 10.3390/membranes15090256 UR - https://m2.mtmt.hu/api/publication/36645610 ID - 36645610 LA - English DB - MTMT ER - TY - JOUR AU - Wei, Haochun AU - Nong, Haibiao AU - Chen, Li AU - Zhang, Shiyu TI - Advanced Materials-Based Nanofiltration Membranes for Efficient Removal of Organic Micropollutants in Water and Wastewater Treatment JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 8 SP - 236 SN - 2077-0375 DO - 10.3390/membranes15080236 UR - https://m2.mtmt.hu/api/publication/36281362 ID - 36281362 AB - The increasing use of pharmaceutically active compounds (PhACs), endocrine-disrupting compounds (EDCs), and personal care products (PCPs) has led to the widespread presence of organic micropollutants (OMPs) in aquatic environments, posing a significant global challenge for environmental conservation. In recent years, advanced materials-based nanofiltration (NF) technologies have emerged as a promising solution for water and wastewater treatment. This review begins by examining the sources of OMPs, as well as the risk of OMPs. Subsequently, the key criteria of NF membranes for OMPs are discussed, with a focus on the roles of pore size, charge property, molecular interaction, and hydrophilicity in the separation performance. Against that background, this review summarizes and analyzes recent advancements in materials such as metal organic frameworks (MOFs), covalent organic frameworks (COFs), graphene oxide (GO), MXenes, hybrid materials, and environmentally friendly materials. It highlights the porous nature and structural diversity of organic framework materials, the advantage of inorganic layered materials in forming controllable nanochannels through stacking, the synergistic effects of hybrid materials, and the importance of green materials. Finally, the challenges related to the performance optimization, scalable fabrication, environmental sustainability, and complex separation of advanced materials-based membranes for OMP removal are discussed, along with future research directions and potential breakthroughs. LA - English DB - MTMT ER - TY - JOUR AU - Życki, Maciej AU - Barszcz, Wioletta AU - Łożyńska, Monika TI - Treatment of Dairy Wastewater Retentate After Microfiltration: Evaluation of the Performance of the System Based on Activated Sludge and Activated Carbon JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 8 SP - 237 SN - 2077-0375 DO - 10.3390/membranes15080237 UR - https://m2.mtmt.hu/api/publication/36282471 ID - 36282471 AB - The dairy industry generates significant amounts of wastewater, including microfiltration (MF) retentate, a byproduct thickened with organic and inorganic pollutants. This study focuses on the treatment of two times concentrated MF retentate using a hybrid system based on biological treatment in a sequential batch reactor (SBR) and adsorption on activated carbon. The first stage involved cross-flow microfiltration using a 0.2 µm PVDF membrane at 0.5 bar, resulting in reductions of 99% in turbidity and 79% in chemical oxygen demand (COD), as well as a partial reduction in conductivity. The second stage involved 24-h biological treatment in a sequential batch reactor (SBR) with activated sludge (activated sludge index: 80 cm3/g, MLSS 2500 mg/dm3), resulting in further reductions in COD (62%) and TOC (30%), as well as the removal of 46% of total phosphorus (TP) and 35% of total nitrogen (TN). In the third stage, the decantate underwent adsorption in a column containing powdered activated carbon (PAC; 1 g; S_(BET) = 969 m2 g−1), reducing the concentrations of key indicators to the following levels: COD 84%, TOC 70%, TN 77%, TP 87% and suspended solids 97%. Total pollutant retention ranged from 24.6% to 97.0%. These results confirm that the MF–SBR–PAC system is an effective, compact solution that significantly reduces the load of organic and biogenic pollutants in MF retentates, paving the way for their reuse or safe discharge into the environment. LA - English DB - MTMT ER - TY - JOUR AU - Grosso, Valentina AU - Rizzuto, Carmen AU - Tocci, Elena AU - Fuoco, Alessio AU - Longo, Mariagiulia AU - Monteleone, Marcello AU - Hajivand, Pegah AU - Jansen, Johannes C. AU - Esposito, Elisa TI - Review of Hollow Fiber Membranes for Gas Separation: Exploring Fundamentals and Recent Advancements JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 8 PG - 52 SN - 2077-0375 DO - 10.3390/membranes15080246 UR - https://m2.mtmt.hu/api/publication/36568082 ID - 36568082 LA - English DB - MTMT ER - TY - JOUR AU - Nowik-Zajac, Anna AU - Sabadash, Vira TI - Recent Developments in Polymer Inclusion Membranes: Advances in Selectivity, Structural Integrity, Environmental Applications and Sustainable Fabrication JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 8 PG - 40 SN - 2077-0375 DO - 10.3390/membranes15080249 UR - https://m2.mtmt.hu/api/publication/36696260 ID - 36696260 LA - English DB - MTMT ER - TY - JOUR AU - Atiq, Omar AU - Martinez, Gonzalo Agustin AU - Bertin, Lorenzo AU - Bandini, Serena TI - Intrinsic Performances of Reverse Osmosis and Nanofiltration Membranes for the Recovery and Concentration of Multicomponent Mixtures of Volatile Fatty Acids: A Semi-Pilot Study JF - MEMBRANES (BASEL) J2 - MEMBRANES-BASEL VL - 15 PY - 2025 IS - 8 PG - 23 SN - 2077-0375 DO - 10.3390/membranes15080221 UR - https://m2.mtmt.hu/api/publication/36731749 ID - 36731749 LA - English DB - MTMT ER -