@article{MTMT:34828410, title = {Insights into treatment of complex Crohn's perianal fistulas}, url = {https://m2.mtmt.hu/api/publication/34828410}, author = {Norčič, Gregor and Smrekar, Nataša and Marković, Srđan and Barišić, Goran and Kiudelis, Gediminas and Paužas, Henrikas and Molnár, Tamás and Szijártó, Attila and Šerclová, Zuzana and Roblek, Tina and Uršič, Viktor and White, Ian}, doi = {10.1186/s12919-024-00291-4}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {34828410}, abstract = {Complex perianal fistula is a common complication of Crohn's disease (CD) which leads to negative impact on patient's quality of life. Successful management of the disease requires a multidisciplinary approach, including a gastroenterologist and a colorectal surgeon, applying combined surgical and medical therapy. One of frequently practiced surgical procedures is seton placement in the fistula tract, which is used to control perianal sepsis and drain the fistula, while preventing recurrent abscess formation.Darvadstrocel, a suspension of expanded, allogeneic, adipose-derived, mesenchymal stem cells, is safe and effective for treatment-refractory complex perianal fistulas in patients with Crohn's disease. Following approval of darvadstrocel, the INSPIRE registry is being conducted in order to evaluate long-term safety and effectiveness of the drug on a large, heterogenous population.An online expert meeting was held from March 20 to March 30, 2023, which provided relevant insights into the decision-making process regarding seton use and obtained feedback on the first experiences with darvadstrocel. The aim of this article is to present the perspectives from gastroenterologists and colorectal surgeons practicing in Czechia, Hungary, Israel, Lithuania, Serbia, and Slovenia in topics such as diagnosis and treatment options for patients with complex Crohn's perianal fistulas (CPF), specifically focusing on the use of setons and darvadstrocel.During this virtual session, unavailability of comprehensive data on safety and efficacy of available treatment procedures was emphasized as an important obstacle towards development of standardized recommendations and improvement of outcomes in treatment of (CPF). Furthermore, achieving consensus in seton use, duration of its placement, and frequency of change is recognized as one of CPF treatments major challenges. Despite these issues, it is important to promote better understanding and treatment of complex perianal fistulas in order to improve the quality of life of those affected by this condition.}, keywords = {Crohn's disease; Multidisciplinary management; Surgical procedures; Perianal fistulas; long-term safety evaluation; treatment challenges; Darvadstrocel Therapy}, year = {2024}, eissn = {1753-6561}, orcid-numbers = {Molnár, Tamás/0000-0002-4913-7599} } @article{MTMT:34630550, title = {Unmet needs in EGFR exon 20 insertion mutations in Central and Eastern Europe. reimbursement, diagnostic procedures, and treatment availability.}, url = {https://m2.mtmt.hu/api/publication/34630550}, author = {Hochmair, Maximilian J and Unk, Mojca and Spasic, Jelena and Cerić, Timur and Konsoulova, Assia and Dediu, Mircea and Bogos, Krisztina and Hegmane, Alinta and Oselin, Kersti and Stojiljkovic, Marko and Roblek, Tina and Jakopovic, Marko}, doi = {10.1186/s12919-023-00287-6}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {34630550}, abstract = {Lung cancer remains the leading cause of cancer-related deaths in Europe, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of cases. NSCLC is a heterogeneous disease encompassing various oncogenic alterations. Among them, EGFR exon 20 insertion mutations, constituting 0.3-2.2% of NSCLC cases, rank as the third most common EGFR alteration after exon 19 deletions and the L858R point mutation in exon 21, also known as "typical" EGFR alterations. Recent advancements in understanding the molecular pathogenesis of NSCLC have led to significant breakthroughs in targeted therapies, revolutionizing treatment options for patients with specific genetic alterations.This article presents the outcomes of a Virtual Meeting conducted on the online platform (provided Within3©) from September 19 to October 30, 2022. The meeting focused on addressing the challenges in the diagnosis and treatment of NSCLC patients with EGFR exon 20 insertion mutations. The participants consisted of healthcare professionals from ten Central and Eastern European countries who shared their experiences and opinions on various aspects, including epidemiology, treatment options, and diagnostic approaches employed in their respective healthcare institutions. The discussions were facilitated through open-ended and multiple-choice questions.The primary objective of this article is to provide an overview of the identified challenges associated with the diagnosis and treatment of this heterogeneous disease, based on the assessments of the meeting participants. Among the major emerging challenges discussed, the reimbursement issues concerning next-generation sequencing (NGS), a recommended method in NSCLC molecular diagnosis, and the availability of approved targeted treatments to enhance patient outcomes were of paramount importance. Furthermore, fostering community awareness of lung cancer and promoting harmonized lung cancer care were identified as areas deserving greater attention. Notably, the rapidly evolving treatment landscape, particularly with NGS for NSCLC patients with genomic alterations like EGFR, ALK, RET, MET, NTRK, and ROS1, necessitates prioritizing the development of new drugs, even for the relatively smaller subgroup with exon 20 insertion mutations.}, keywords = {Next-generation sequencing; Targeted therapies; Diagnostic challenges; EGFR exon 20 insertion mutations; Healthcare disparities in Central and Eastern Europe; NSCLC treatment}, year = {2024}, eissn = {1753-6561} } @article{MTMT:35157615, title = {A study of the efectiveness of core training with EMG in recreational kayak and canoe athletes}, url = {https://m2.mtmt.hu/api/publication/35157615}, author = {Melczer, Csaba and Laczkó, Tamás and Raposa, Bence and Tardi, Péter and Czakó, Dorina Evelin}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {35157615}, year = {2024}, eissn = {1753-6561}, pages = {56-56}, orcid-numbers = {Melczer, Csaba/0000-0002-8197-0572; Raposa, Bence/0000-0001-9551-8440; Tardi, Péter/0000-0002-5091-7373} } @article{MTMT:35157633, title = {Role of sports in the psychological well-being of Hungarian adult population in COVID-19 pandemic}, url = {https://m2.mtmt.hu/api/publication/35157633}, author = {Laczkó, Tamás and Melczer, Csaba and Morvay-Sey, Kata Ilona and Stocker, Miklós}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {35157633}, year = {2024}, eissn = {1753-6561}, pages = {58-58}, orcid-numbers = {Melczer, Csaba/0000-0002-8197-0572; Morvay-Sey, Kata Ilona/0000-0001-5468-9358; Stocker, Miklós/0000-0003-2670-6717} } @article{MTMT:35218000, title = {The importance of health behavior for infertility-specific quality of life, with particular regard to physical activity}, url = {https://m2.mtmt.hu/api/publication/35218000}, author = {Prémusz, Viktória and Skriba, Eszter and Szmatona, Gábor and Tándor, Zoltán and Kovács, Kálmán András and Várnagy, Ákos}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {35218000}, year = {2024}, eissn = {1753-6561}, pages = {58-58}, orcid-numbers = {Prémusz, Viktória/0000-0002-4059-104X; Skriba, Eszter/0009-0004-9415-8606} } @article{MTMT:35258622, title = {Correlations between smartphone use and physical activity among Hungarian university students}, url = {https://m2.mtmt.hu/api/publication/35258622}, author = {Horváthné Tóth, Bettina and Salamon, András and Császár, Gabriella Edit}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {35258622}, year = {2024}, eissn = {1753-6561}, pages = {54-54}, orcid-numbers = {Horváthné Tóth, Bettina/0000-0001-8879-8560; Salamon, András/0000-0003-4453-0495; Császár, Gabriella Edit/0000-0002-5435-6622} } @article{MTMT:35719761, title = {The potential use of virtual reality in the treatment of anxiety in athletes}, url = {https://m2.mtmt.hu/api/publication/35719761}, author = {Trpkovici, Melinda and Krisztina, Rácz and Prémusz, Viktória}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {35719761}, year = {2024}, eissn = {1753-6561}, pages = {55-55}, orcid-numbers = {Prémusz, Viktória/0000-0002-4059-104X} } @article{MTMT:35205079, title = {The change in the popularity of online workouts among the Hungarian population during the pandemic period}, url = {https://m2.mtmt.hu/api/publication/35205079}, author = {Derkács, Evelin Andrea and Makai, Alexandra}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {35205079}, year = {2024}, eissn = {1753-6561}, pages = {56-56}, orcid-numbers = {Makai, Alexandra/0000-0002-1907-120X} } @article{MTMT:35295169, title = {Comparison of motor skills among junior triathlon athletes}, url = {https://m2.mtmt.hu/api/publication/35295169}, author = {Balog, Ádám and Alföldi, Zoltán and Horváth-Pápai, Anna and Ihász, Ferenc}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {35295169}, year = {2024}, eissn = {1753-6561}, pages = {52}, orcid-numbers = {Alföldi, Zoltán/0000-0002-5486-6665; Ihász, Ferenc/0000-0003-0213-2237} } @article{MTMT:35141210, title = {The relationship between sitting time with exercise habits, body composition and bone density}, url = {https://m2.mtmt.hu/api/publication/35141210}, author = {Győri, Ferenc József and Vári, Beáta and Halasi, Szabolcs and Herczeg, Gábor and Berki, Tamás}, journal-iso = {BMC PROCEEDINGS}, journal = {BMC PROCEEDINGS}, volume = {18}, unique-id = {35141210}, year = {2024}, eissn = {1753-6561}, pages = {52-53}, orcid-numbers = {Győri, Ferenc József/0000-0002-9989-0028; Berki, Tamás/0000-0001-6944-2331} }