TY - JOUR AU - Yang, Fen TI - Effect of ultrasound-guided stellate ganglion block on cerebral oxygen metabolism and S100B protein during carotid endarterectomy JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 16 PY - 2024 IS - 3 SP - 1018 EP - 1028 PG - 11 SN - 1943-8141 DO - 10.62347/RXRN7802 UR - https://m2.mtmt.hu/api/publication/34795611 ID - 34795611 LA - English DB - MTMT ER - TY - JOUR AU - Yan, Jin-Hua AU - Liao, Kai-Qiong AU - Yao, Ling AU - Chen, Jian-Lan AU - Xiong, Li-Fang AU - Tao, Xu-Zhang TI - LncRNA AL645608.3 mediates malignant progression of acute myeloid leukemia JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 16 PY - 2024 IS - 1 SP - 342 EP - 355 PG - 14 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/34657623 ID - 34657623 LA - English DB - MTMT ER - TY - JOUR AU - Wang, Tongling AU - Zhao, Cuiqing AU - Guo, Zhangjian TI - Comparative analysis of ankle injury kinematics and dynamics in basketball players: forefoot landing vs. rearfoot landing modes JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 15 PY - 2023 IS - 9 SP - 5843 EP - 5849 PG - 7 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/34665764 ID - 34665764 LA - English DB - MTMT ER - TY - JOUR AU - Chen, Fuying AU - Xu, Yan AU - Wang, Zhen TI - Ulinastatin combined with somatostatin enhances disease control and modulates serum inflammatory factors in patients with severe pancreatitis JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 15 PY - 2023 IS - 9 SP - 5797 EP - 5807 PG - 11 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/34636173 ID - 34636173 LA - English DB - MTMT ER - TY - JOUR AU - Zhou, Haidong AU - Lu, Dinggui AU - Yu, Dianbo AU - Luo, Changtai AU - Xie, Kangqi AU - Ma, Huade AU - Li, Shanlang AU - Liang, Jiyun AU - Wei, Fengxu AU - Chen, Luchang AU - Luo, Dong AU - Wang, Wei AU - Wei, Jihua TI - Pan-cancer analysis of the oncogenic role of the core osteosarcoma gene VCAN in human tumors JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 15 PY - 2023 IS - 9 SP - 5556 EP - 5573 PG - 18 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/34506165 ID - 34506165 N1 - Funding Agency and Grant Number: National Natural Science Foundation of China [822-60887]; Guangxi Natural Science Foundation [2020GXNSFAA259068]; first batch of high-level talent research projects of the hospital affiliated to the Right River Ethnic Medical College [R20196321]; Guangxi Medical and Health Appropriate Technology Development and Application Project [YZCXJH2022004]; Innovation Program for Master's Degree Students of Right River School of Ethnic Medicine; [S201917] Funding text: This work was supported by the National Natural Science Foundation of China (822-60887) , Guangxi Natural Science Foundation (2020GXNSFAA259068) , The first batch of high-level talent research projects of the hospital affiliated to the Right River Ethnic Medical College (R20196321) , Innovation Program for Master's Degree Students of Right River School of Ethnic Medicine (YZCXJH2022004) , and Guangxi Medical and Health Appropriate Technology Development and Application Project (S201917) . AB - Objective: Versican (VCAN), a member of the multifunctional glycoprotein family, is involved in various aspects of cancer progression. However, the role of VCAN in diverse cancers remains poorly defined. This research aimed to investigate the correlation between VCAN expression and the oncogenic role, as well as visualize its prognostic landscape in pan-cancer. Methods: Raw data in regard to VCAN expression in cancer patients were acquired from GEO GeneChip public database in NCBI. Besides, we selected microarray data GSE16088 for analysis. We retrieved the genes associated with osteosarcoma (OS) from the OMIM database and identified their intersection with the core module. VCAN was suggested to be a potential marker gene for OS. Subsequently, we conducted Gene Set Enrichment Analysis (GSEA) to explore gene functional enrichment. Moreover, we performed pan-cancer analysis on VCAN to gain a comprehensive understanding of its implications across various cancer types. Results: The VCAN expression in the tumor tissue was higher than that in normal tissue. Elevated expression of VCAN was associated with high the tumor stage and poor long-term survival. There was a significant positive correlation between VCAN and cancer fibroblasts in all pan cancers. Moreover, FBN1 was the intersection gene of VCAN-related genes and linker genes. ANTXR1, COL5A2, CSGALNACT2, and SPARC were the target genes of VCAN genes. GSEA analysis showed that VCAN was mainly enriched in the extracellular matrix (ECM) signaling pathway. Conclusion: VCAN can be used as a marker molecule for the early diagnosis of OS and holds significance as a molecule in cases of OS with distant metastasis. The ECM signaling pathway may be a core pathway in OS development and distant metastasis. These findings shed new light on therapeutics of cancers. LA - English DB - MTMT ER - TY - JOUR AU - Sun, Xiaoxia AU - Wei, Congying AU - Li, Lei AU - Qu, Chao TI - Levosimendan improves cardiac function, hemodynamics, and body inflammation in patients with acute myocardial infarction and heart failure JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 15 PY - 2023 IS - 9 SP - 5624 EP - 5632 PG - 9 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/34323706 ID - 34323706 AB - Objective: To examine the effects of levosimendan on cardiac function, hemodynamics, and body inflammation of patients with acute myocardial infarction and heart failure. Methods: A retrospective analysis was conducted on 113 acute myocardial infarction patients with heart failure (admitted to Xianyang First People's Hospital from September 2018 to January 2022). According to the treatment plan, patients were categorized into a control group (n = 53) (treated with conventional diuresis and vasodilation) and observation group (n = 60) (treated with levosimendan in addition to the treatment of the control group). Indexes were compared between the two groups before and after treatment, including effectiveness rate, mean pulmonary arterial pressure (PAMP) and pulmonary eter (LVESD) and left ventricular ejection fraction (LVEF) were monitored before and after treatment by color Doppler ultrasonography. Serum high-sensitivity C-reactive protein (hs-CRP) levels were measured before and after treatment. Logistic analysis was applied to screen independent factors affecting treatment efficacy. Adverse reactions and life quality after 6 months of treatment were compared between the two groups. Results: The overall response rate of the observation group was higher than that of the control group (P<0.05). Changes in PAMP and PCWP in the two groups before and after treatment were significantly different. Patients in the observation group had improved indicators compared with the control group (all P<0.05). After treatment, the cardiac function indexes and inflammation-related factors of the observation group were improved more than those of the control group (P<0.05). Patients in the observation group had a lower incidence of adverse reactions and a higher life quality 6 months after treatment compared to the control group (P<0.05). Diabetes and treatment regimen were independent risk factors affecting treatment efficacy by logistic regression analysis. Conclusion: The administration of levosimendan helps improve cardiac function, hemodynamics, and body inflammation in patients with acute myocardial infarction and heart failure, with fewer adverse reactions and higher safety. LA - English DB - MTMT ER - TY - JOUR AU - Yang, Jinjing AU - Ma, Xiurui AU - Niu, Dan AU - Sun, Yu AU - Chai, Xiaohong AU - Deng, Yongzhi AU - Wang, Jingping AU - Dong, Jin TI - PCSK9 inhibitors suppress oxidative stress and inflammation in atherosclerotic development by promoting macrophage autophagy JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 15 PY - 2023 IS - 8 SP - 5129 EP - + PG - 17 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/34640715 ID - 34640715 LA - English DB - MTMT ER - TY - JOUR AU - Zhang, Jun AU - Xu, Xiaoyan AU - Liang, Ying AU - Wu, Xiaomin AU - Qian, Zhongqing AU - Zhang, Liming AU - Wang, Ting TI - Particulate matter promotes the epithelial to mesenchymal transition in human lung epithelial cells via the ROS pathway JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 15 PY - 2023 IS - 8 SP - 5159 EP - + PG - 11 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/34592257 ID - 34592257 AB - Objects: Epidemiologic studies have linked exposure to airborne pollutant particulate matter (PM) with increased rates of chronic cardiopulmonary diseases, including asthma and idiopathic pulmonary fibrosis (IPF). Several investigations have suggested that the epithelial-to-mesenchymal transition (EMT) may contribute to the complex pathobiology of environmental exposure-mediated pulmonary fibrosis. The present study was designed to characterize the mechanisms of PM-mediated EMT in human lung epithelial cells (HBECs). Methods and results: PM induced significant dose (0-100 mu g/ml) and time (0-72 h)-dependent increases in transforming growth factor beta (TGF beta) and fibronectin (FN) protein levels in HBECs lysates. PM-activated TGF beta and FN protein production in HBECs was prevented by the antioxidant N-acetyl-cysteine (NAC, 5 mM). Furthermore, the NF-KB inhibitor BAY11-7082 (5 mu M) abolished PM-induced FN production in HBECs. Biomarkers of EMT (ACTA2, SNAIL1 and SNAIL2) in PM-treated HBECs were significantly increased at the mRNA level compared to control cells. Conclusions: These results demonstrate that PM increases protein levels of TGF beta and FN via reactive oxygen species (ROS)-dependent pathways. In addition, PM exposure induces EMT in human lung epithelial cells, supporting a novel mechanism for PM-induced pulmonary fibrosis. LA - English DB - MTMT ER - TY - JOUR AU - Wei, Shanzhai AU - Sun, Jie AU - Xu, Kangchun AU - Li, Yibei AU - Zhang, Yilai TI - Safety and effectiveness of recombinant human erythropoietin coupled with different doses of Roxadustat for treatment of renal anemia in patients on maintenance hemodialysis JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 15 PY - 2023 IS - 8 SP - 5120 EP - 5128 PG - 9 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/34503769 ID - 34503769 AB - Objective: To investigate the safety and efficacy of recombinant human erythropoietin (rHuEPO) in com-bination with different doses of Roxadustat in treating renal anemia in patients on maintenance hemodialysis. Methods: Eighty patients with renal anemia on maintenance hemodialysis treated in Shuyang Hospital of Traditional Chinese Medicine from January 2020 to December 2021 were selected as study subjects, and they were divided into a study group (n=40, high-dose Roxadustat + rHuEPO therapy) and a control group (Con) (n=40, low-dose Roxadustat + rHuEPO therapy) in accordance with different therapies. The effects of anemia therapy, changes in anemia indicators (hemoglobin (Hb), hematocrit (Hct)), changes in iron metabolism indicators (transferrin saturation (TSAT), serum ferritin (SF)), changes in oxidative stress indicators Malondialdehyde (MDA), Superoxide Dismutase (SOD), and changes in microinflammatory indicators IL6, CRP were compared between the two groups. The occur-rences of adverse effects during therapy were counted and compared between the two groups. Results: The therapy efficiency of the study group was 97.50% (39/40), which was higher than 85.00% (34/40) in the control group (P=0.048). The contents of Hb, Hct, TSAT, and SF were higher in the study group than the Con after therapy (all P<0.001 or P=0.001). The contents of MDA, IL6, and CRP were significantly lower in the study group than the Con after therapy (all P<0.001). The occurrence of adverse effects was 10.00% in the study group, which was higher than 5.00% in the Con, but the difference was not significant (P=0.396). Conclusion: The combination of rHuEPO and high-dose Roxadustat (120 mg/time) has a better effect on improving anemia symptoms in maintenance he-modialysis patients than in those who take low dose Roxadustat (100 mg/time). It can significantly improve anemia and iron metabolism indicators and alleviate patients' inflammation and oxidative stress levels. LA - English DB - MTMT ER - TY - JOUR AU - Xie, Ting AU - Ren, Xunshan AU - Zhuang, Huangming AU - Jiang, Fuze AU - Zhang, Yuelong AU - Zhou, Panghu TI - Down-regulation of Jun induces senescence through destabilizing chromatin in osteoarthritis chondrocytes JF - AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH J2 - AM J TRANSL RES VL - 15 PY - 2023 IS - 7 SP - 4873 EP - + PG - 15 SN - 1943-8141 UR - https://m2.mtmt.hu/api/publication/34366804 ID - 34366804 AB - Objective: Osteoarthritis (OA) is the most common degenerative joint disease leading to disability worldwide. Cellular senescence is considered to be a fundamental pathogenic mechanism in the development of OA and has attracted increasing attention. However, regulatory mechanisms underlying chondrocyte senescence in OA remain unclear. Methods: Bioinformatic methods were used to screen key genes. Immunohistochemistry and the quantitative reverse transcription polymerase chain reaction were used to evaluate gene expression. RNA intervention experiments were performed to explore the functions of key genes. Results: We used 494 aging-associated genes provided by the Aging Atlas to identify the co-expression modules associated with age and OA. Thirty age-associated differentially expressed genes (ASDEGs) were identified. Using cytoHubba in Cytoscape, we identified Jun as the hub-ASDEG for OA chondrocytes. We confirmed the downregulation of Jun in OA rats and senescent chondrocytes by immunohistochemistry and quantitative reverse transcription polymerase chain reaction, respectively. Inhibition of proliferation and accelerated senescence were observed in chondrocytes treated with siRNA against Jun. Mechanistically, we observed micronuclei formation and reduced expression of H3K9me3 and heterochromatin protein 1gamma in siRNA-Jun-treated chondrocytes, indicating that destabilization of chromatin occurred during this treatment. Conclusion: Jun plays a crucial role in OA development and causes senescence by destabilizing chromatin in chondrocytes. These findings provide new insights into OA progression and suggest promising therapeutic targets. LA - English DB - MTMT ER -